Updated on 2022/04/13

写真a

 
NISHIWAKI, Kimitoshi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Development Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor
External link

Degree 1

  1. 医学博士 ( 1995.4   名古屋大学 ) 

Research Interests 3

  1. Anesthesiology, Critical care medicine, Pain clinic

  2. Pain clinic

  3. Critical care medicine

Research Areas 1

  1. Others / Others  / Anesthesiology/Resuscitation Studies

Current Research Project and SDGs 1

  1. 肺血管透過性亢進の機序解明

Research History 13

  1. Nagoya University   Nagoya University Hospital Surgical Intensive Care Unit   Director

    2019.4

  2. Nagoya University   Hospital   Vice-director

    2013.4

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    Country:Japan

  3. Nagoya University   Nagoya University Hospital

    2013.4

  4. Nagoya University

    2010.4 - 2012.6

  5. Nagoya University

    2010.4 - 2011.3

  6. Nagoya University   Graduate School of Medicine, Department of Anesthesiology   Professor

    2008.7

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    Country:Japan

  7. Nagoya University   Associate professor

    2007.4 - 2008.6

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    Country:Japan

  8. Nagoya University   Assistant Professor

    2004.12 - 2007.3

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    Country:Japan

  9. Nagoya University   School of Medicine, Department of Anesthesiology   Lecturer

    2000.7 - 2004.11

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    Country:Japan

  10. 名古屋第一赤十字病院    麻酔科   部長

    1998.4 - 2000.6

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    Country:Japan

  11. 名古屋第一赤十字病院   麻酔科   副部長

    1997.4 - 1998.3

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    Country:Japan

  12. Nagoya University   School of Medicine, Department of Anesthesiology   Lecturer

    1996.2 - 1997.3

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    Country:Japan

  13. Nagoya University   School of Medicine, Department of Anesthesiology   Assistant

    1986.4 - 1996.2

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    Country:Japan

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Education 1

  1. Nagoya University   Faculty of Medicine

    1978.4 - 1984.3

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    Country: Japan

Professional Memberships 5

  1. Japanese Society of Anesthesiology

  2. 日本ペインクリニック学会

  3. 日本集中治療医学会

  4. American Society of Anesthesiology

  5. 医療の質安全学会

 

Papers 172

  1. Cerebrospinal fluid drainage to prevent postoperative spinal cord injury in thoracic aortic repair Reviewed International journal

    Yoshitani Kenji, Kawaguchi Masahiko, Kawamata Mikito, Kakinohana Manabu, Kato Shinya, Hasuwa Kyoko, Yamakage Michiaki, Yoshikawa Yusuke, Nishiwaki Kimitoshi, Hasegawa Kazuko, Inagaki Yoshimi, Funaki Kazumi, Matsumoto Mishiya, Ishida Kazuyoshi, Yamashita Atsuo, Seo Katsuhiro, Kakumoto Shinichi, Tsubaki Kosuke, Tanaka Satoshi, Ishida Takashi, Uchino Hiroyuki, Kakinuma Takayasu, Yamada Yoshitsugu, Mori Yoshiteru, Izumi Shunsuke, Shimizu Jun, Furuichi Yuko, Kin Nobuhide, Uezono Shoichi, Kida Kotaro, Nishimura Kunihiko, Nakai Michikazu, Ohnishi Yoshihiko

    JOURNAL OF ANESTHESIA   Vol. 35 ( 1 ) page: 43 - 50   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Anesthesia  

    DOI: 10.1007/s00540-020-02857-w

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  2. Hypofibrinogenemia can be estimated by the predictive formula in aortic surgery Reviewed International journal

    Nishi Toshihiko, Mutsuga Masato, Akita Toshiaki, Narita Yuji, Fujimoto Kazuro, Tokuda Yoshiyuki, Nishida Kazuki, Matsui Shigeyuki, Nishiwaki Kimitoshi, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY     2021.1

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    Publishing type:Research paper (scientific journal)   Publisher:General Thoracic and Cardiovascular Surgery  

    DOI: 10.1007/s11748-021-01594-5

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  3. Accuracy of landmark scalp blocks performed during asleep-awake-asleep awake craniotomy: a retrospective study Reviewed International journal

    Sato Takehito, Nishiwaki Kimitoshi

    JA CLINICAL REPORTS   Vol. 7 ( 1 ) page: 8   2021.1

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    DOI: 10.1186/s40981-021-00412-4

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  4. Novel anesthetic agent remimazolam as an alternative for the asleep-awake-asleep technique of awake craniotomy Reviewed International journal

    Sato Takehito, Kato Yumi, Yamamoto Mayumi, Nishiwaki Kimitoshi

    JA CLINICAL REPORTS   Vol. 6 ( 1 ) page: 92   2020.12

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    DOI: 10.1186/s40981-020-00398-5

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  5. Coagulation ability when separating from cardiopulmonary bypass with and without fresh frozen plasma: a pilot study Reviewed International journal

    Tamura Takahiro, Yokota Shuichi, Ito Toshiaki, Ando Masahiko, Kubo Yoko, Waters Jonathan H, Nishiwaki Kimitoshi

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 68 ( 12 ) page: 1361 - 1368   2020.12

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    DOI: 10.1007/s11748-020-01372-9

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  6. Lidocaine inhibits vascular endothelial growth factor-A-induced angiogenesis. Reviewed International journal

    Suzuki S, Mori A, Fukui A, Ema Y, Nishiwaki K

    Journal of anesthesia   Vol. 34 ( 6 ) page: 857 - 864   2020.12

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    DOI: 10.1007/s00540-020-02830-7

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  7. Comparing oscillometric noninvasive and invasive intra-arterial blood pressure monitoring in term neonates under general anesthesia: A retrospective study Reviewed International journal

    Fujii Tasuku, Nishiwaki Kimitoshi

    PEDIATRIC ANESTHESIA   Vol. 30 ( 12 ) page: 1396 - 1401   2020.12

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Paediatric Anaesthesia  

    DOI: 10.1111/pan.14020

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  8. Desflurane and sevoflurane concentrations in blood passing through the oxygenator during cardiopulmonary bypass: a randomized prospective pilot study Reviewed International journal

    Tamura Takahiro, Mori Atsushi, Ishii Akira, Ando Masahiko, Kubo Yoko, Nishiwaki Kimitoshi

    JOURNAL OF ANESTHESIA   Vol. 34 ( 6 ) page: 904 - 911   2020.12

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    Authorship:Last author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Journal of Anesthesia  

    DOI: 10.1007/s00540-020-02844-1

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  9. Preanesthesia scalp blocks reduce intraoperative pain and hypertension in the asleep-awake-asleep method of awake craniotomy: A retrospective study. Reviewed International journal

    Sato T, Okumura T, Nishiwaki K

    Journal of clinical anesthesia   Vol. 66   page: 109946   2020.11

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    Authorship:Last author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jclinane.2020.109946

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  10. Prompt prediction of fibrinogen concentration during cardiopulmonary bypass: a pilot study Reviewed International journal

    Tamura Takahiro, Imaizumi Takahiro, Kubo Yoko, Waters Jonathan H., Nishiwaki Kimitoshi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 4 ) page: 623 - 630   2020.11

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   Publisher:Nagoya Journal of Medical Science  

    DOI: 10.18999/nagjms.82.4.623

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  11. Transverse vs. parasagittal in-plane approaches in ultrasound-guided paravertebral block using a microconvex probe: A randomised controlled trial. Reviewed International journal

    Fujii T, Shibata Y, Shinya S, Nishiwaki K

    European journal of anaesthesiology   Vol. 37 ( 9 ) page: 752 - 757   2020.9

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    DOI: 10.1097/EJA.0000000000001223

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  12. Heparin concentration in cell salvage during heparinization: a pilot study Reviewed International journal

    Tamura Takahiro, Waters Jonathan H., Nishiwaki Kimitosi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 3 ) page: 449 - 455   2020.8

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   Publisher:Nagoya Journal of Medical Science  

    DOI: 10.18999/nagjms.82.3.449

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  13. The incidence and risk factors of hypofibrinogenemia in cardiovascular surgery Reviewed International journal

    Nishi Toshihiko, Mutsuga Masato, Akita Toshiaki, Narita Yuji, Fujimoto Kazuro, Tokuda Yoshiyuki, Terazawa Sachie, Ito Hideki, Nishiwaki Kimitoshi, Usui Akihiko

    GENERAL THORACIC AND CARDIOVASCULAR SURGERY   Vol. 68 ( 4 ) page: 335 - 341   2020.4

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    DOI: 10.1007/s11748-019-01201-8

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  14. Chronic pain after breast surgery - still many unanswered questions: a reply Reviewed International journal

    Fujii T, Nishiwaki K

    ANAESTHESIA   Vol. 75 ( 3 ) page: 416 - 417   2020.3

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    DOI: 10.1111/anae.14982

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  15. Clarification on chronic pain - a painfully persistent problem? A reply Reviewed International journal

    Fujii T, Nishiwaki K

    ANAESTHESIA   Vol. 75 ( 3 ) page: 408 - 409   2020.3

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    DOI: 10.1111/anae.14960

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  16. Efficacy of pectoral nerve block type-2 (Pecs II block) versus serratus plane block for postoperative analgesia in breast cancer surgery: a retrospective study Reviewed International journal

    Kubodera Kazumi, Fujii Tasuku, Akane Akiko, Aoki Wakana, Sekiguchi Akiko, Iwata Keiko, Ban Makiko, Ando Reiko, Nakamura Nozomi, Shibata Yasuyuki, Nishiwaki Kimitoshi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 1 ) page: 93 - 99   2020.2

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    DOI: 10.18999/nagjms.82.1.93

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  17. Transesophageal echocardiography used for transvenous pacemaker implantation in a patient with cardiac tumors: a case report Reviewed

    Takakura Masashi, Sato Takehito, Fujii Tasuku, Takeda Michihiro, Nishiwaki Kimitoshi

    Cardiovascular Anesthesia   Vol. 24 ( 1 ) page: 173 - 177   2020

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:Japanese Society of Cardiovascular Anesthesiologists  

    <p> In this report, we describe the case of a patient with a massive primary cardiac malignant lymphoma who underwent anesthetic management for transvenous pacemaker implantation, which was safely performed using combined transesophageal echocardiography (TEE) and fluoroscopy intraoperatively with pacing lead placement guided by echocardiography.</p><p> A 71 year-old male was diagnosed with a massive cardiac malignant lymphoma. The tumor occupied the right atrium and ventricle, as well as the vena cava. Electrocardiography revealed a complete atrioventricular block. Elective pacemaker implantation under general anesthesia was planned. General anesthesia was carefully introduced with extracorporeal circulation on stand-by in case of collapsed circulation.</p><p> Intraoperatively, guiding the pacing lead to the proper position was difficult for the cardiovascular surgeon. The anesthesiologist then suggested the use of TEE for guiding the pacing lead. Subsequently, the pacing lead was successfully placed in the appropriate position by a combination of TEE guidance and fluoroscopy without any cardiovascular complications.</p><p> TEE guidance may be considered feasible and efficient for transvenous pacemaker implantation under general anesthesia.</p>

    DOI: 10.11478/jscva.2020-2-006

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  18. A randomised controlled trial of pectoral nerve-2 (PECS 2) block vs. serratus plane block for chronic pain after mastectomy Reviewed International journal

    Fujii T, Shibata Y, Akane A, Aoki W, Sekiguchi A, Takahashi K, Matsui S, Nishiwaki K

    ANAESTHESIA   Vol. 74 ( 12 ) page: 1558 - 1562   2019.12

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    DOI: 10.1111/anae.14856

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  19. Incidence of reexpansion pulmonary edema in minimally invasive cardiac surgery Reviewed International journal

    Tamura Takahiro, Ito Toshiaki, Yokota Shuichi, Ito Shigeki, Kuno Yoko, Ando Masahiko, Nishiwaki Kimitoshi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 4 ) page: 647 - 654   2019.11

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    DOI: 10.18999/nagjms.81.4.647

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  20. A Drainage System to Decrease Volatile Anesthetic Leakage for the Several Types of Oxygenators During Cardiopulmonary Bypass Reviewed International journal

    Tamura Takahiro, Mori Atsushi, Nishiwaki Kimitoshi

    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA   Vol. 33 ( 9 ) page: 2610 - 2612   2019.9

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    DOI: 10.1053/j.jvca.2019.05.022

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  21. Properties of echoic memory revealed by auditory-evoked magnetic fields Reviewed International journal

    Kinukawa Tomoaki, Takeuchi Nobuyuki, Sugiyama Shunsuke, Nishihara Makoto, Nishiwaki Kimitoshi, Inui Koji

    SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page: 12260   2019.8

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    DOI: 10.1038/s41598-019-48796-9

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  22. Comparison between rectus sheath block with 0.25% ropivacaine and local anesthetic infiltration with 0.5% ropivacaine for laparoscopic inguinal hernia repair in children Reviewed International journal

    Tamura Takahiro, Kaneko Kenitiro, Yokota Shuichi, Kitao Takashi, Ando Masahiko, Kubo Yoko, Nishiwaki Kimitoshi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 3 ) page: 341 - 349   2019.8

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    DOI: 10.18999/nagjms.81.3.341

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  23. Association Between Motor-Evoked Potentials and Spinal Cord Damage Diagnosed With Magnetic Resonance Imaging After Thoracoabdominal and Descending Aortic Aneurysm Repair Reviewed International journal

    Hattori Kohshi, Yoshitani Kenji, Kato Shinya, Kawaguchi Masahiko, Kawamata Mikito, Kakinohana Manabu, Yamada Yoshitsugu, Yamakage Michiaki, Nishiwaki Kimitoshi, Izumi Shunsuke, Yoshikawa Yusuke, Mori Yoshiteru, Hasegawa Kazuko, Onishi Yoshihiko

    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA   Vol. 33 ( 7 ) page: 1835 - 1842   2019.7

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    DOI: 10.1053/j.jvca.2018.12.004

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  24. Fibrinogen levels measured by the dry hematology method are lower than those measured by the Clauss method under a high concentration of heparin Reviewed International journal

    Suzuki Shogo, Tamura Takahiro, Hasegawa Kazuko, Maeda Sho, Mori Reona, Kainuma Motoshi, Adachi Yushi, Nishiwaki Kimitoshi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 81 ( 2 ) page: 259 - 267   2019.5

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    DOI: 10.18999/nagjms.81.2.259

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  25. Safety of Fibrinogen Concentrate and Cryoprecipitate in Cardiovascular Surgery: Multicenter Database Study Reviewed International journal

    Maeda Takuma, Miyata Shigeki, Usui Akihiko, Nishiwaki Kimitoshi, Tanaka Hitoshi, Okita Yutaka, Katori Nobuyuki, Shimizu Hideyuki, Sasaki Hiroaki, Ohnishi Yoshihiko, Ueda Yuichi

    JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA   Vol. 33 ( 2 ) page: 321 - 327   2019.2

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    DOI: 10.1053/j.jvca.2018.06.001

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  26. Local anesthetic spread into the paravertebral space with two types of quadratus lumborum blocks: a crossover volunteer study Reviewed International journal

    Tamura Takahiro, Yokota Shuichi, Ito Shigeki, Shibata Yasuyuki, Nishiwaki Kimitoshi

    JOURNAL OF ANESTHESIA   Vol. 33 ( 1 ) page: 26 - 32   2019.2

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    DOI: 10.1007/s00540-018-2578-5

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  27. Clinical Benefit of Preoperative Exercise and Nutritional Therapy for Patients Undergoing Hepato-Pancreato-Biliary Surgeries for Malignancy Reviewed International journal

    Nakajima Hiroki, Yokoyama Yukihiro, Inoue Takayuki, Nagaya Motoki, Mizuno Yota, Kadono Izumi, Nishiwaki Kimitoshi, Nishida Yoshihiro, Nagino Masato

    ANNALS OF SURGICAL ONCOLOGY   Vol. 26 ( 1 ) page: 264 - 272   2019.1

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    DOI: 10.1245/s10434-018-6943-2

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  28. FAM98A is localized to stress granules and associates with multiple stress granule-localized proteins Reviewed International journal

    Ozeki Kanako, Sugiyama Mai, Akter Khondker Ayesha, Nishiwaki Kimitoshi, Asano-Inami Eri, Senga Takeshi

    MOLECULAR AND CELLULAR BIOCHEMISTRY   Vol. 451 ( 1-2 ) page: 107 - 115   2019.1

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    DOI: 10.1007/s11010-018-3397-6

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  29. TRANSFUSION GUIDELINES FOR PATIENTS WITH MASSIVE BLEEDING Reviewed

    Miyata Shigeki, Shimizu Hideyuki, Nishimura Kunihiro, Nishiwaki Kimitoshi, Matsushita Tadashi, Ogawa Satoru, Kino Syuichi, Kubo Takahiko, Saito Nobuyuki, Tanaka Hiroshi, Tamura Takahiro, Itakura Atsuo, Nakai Michikazu, Fujii Satoshi, Maeda Takuma, Maeda Hiroo, Makino Shintaro, Matsunaga Shigetaka, Ueda Yuichi, Usui Akihiko, Okita Yutaka, Ohnishi Yoshihiko, Katori Nobuyuki, Kushimoto Shigeki, Sasaki Hiroaki

    Japanese Journal of Transfusion and Cell Therapy   Vol. 65 ( 1 ) page: 21 - 92   2019

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    Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:The Japan Society of Transfusion Medicine and Cell Therapy  

    DOI: 10.3925/jjtc.65.21

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  30. 胸部傍脊椎ブロックカテーテルの感染範囲の診断に造影CTが有用であった1症例 Reviewed

    新屋 苑恵, 西脇 公俊

    日本ペインクリニック学会誌   Vol. 26 ( 1 ) page: 75 - 76   2019

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    DOI: 10.11321/jjspc.18-0031

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  31. Ventilation Difficulty after Intubation Due to Tracheal Diverticulum Caused by Esophageal Atresia/Tracheoesophageal Fistula Repair Reviewed

    YAMADA Akihiro, OKUMURA Tomoko, MORIMOTO Noriyuki, HASEGAWA Kazuko, ARAKAWA Yoko, NISHIWAKI Kimitoshi

    THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA   Vol. 39 ( 3 ) page: 253 - 256   2019

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    Authorship:Last author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)   Publisher:THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA  

    <p>We experienced a case of ventilation difficulty after intubation due to tracheal diverticulum caused by radical surgery for esophageal atresia/tracheoesophageal fistula repair. The patient was a seven-month-old male infant. Esophageal stricture was found after radical surgery for type C esophageal atresia, so an esophageal balloon dilatation under general anesthesia was scheduled. Tracheal intubation was easily accomplished after general anesthesia was induced, but audible breathing and chest movements were not detected after manual ventilation, so extubation was performed and mask ventilation initiated. Similar ventilation difficulties occurred after re-intubation, but ventilation became possible with a shallow intubation. Upon further investigation using bronchoscopy, it was determined that the ventilation difficulty had been caused by the tip of the tracheal tube straying into a posterior tracheal wall diverticulum. Tracheal diverticulum, which is a complication of radical surgery for esophageal atresia/tracheoesophageal fistula repair, should be considered as a potential cause of ventilation difficulties following intubation.</p>

    DOI: 10.2199/jjsca.39.253

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  32. Spread of Quadratus Lumborum Block to the Paravertebral Space Via Intramuscular Injection: A Volunteer Study Reviewed International journal

    Tamura Takahiro, Kitamura Kana, Yokota Shuichi, Ito Shigeki, Shibata Yasuyuki, Nishiwaki Kimitoshi

    REGIONAL ANESTHESIA AND PAIN MEDICINE   Vol. 43 ( 4 ) page: 372 - 377   2018.5

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    DOI: 10.1097/AAP.0000000000000735

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  33. Catheterization in an ultrasound-guided thoracic paravertebral block using thoracoscopy Reviewed International journal

    Fujii T

    Asian Journal of Anesthesiology   Vol. 55 ( 1 ) page: 24 - 25   2017.3

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    DOI: 10.1016/j.aja.2017.05.004

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  34. 「手術室における医療安全」によせて Reviewed

    近江 明文, 西脇 公俊

    日本臨床麻酔学会誌   Vol. 37 ( 1 ) page: 58 - 58   2017

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    DOI: 10.2199/jjsca.37.58

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  35. Global Trends in Patient Safety in the Perioperative Period:Ratification of the Helsinki Declaration on Patient Safety in Anesthesiology and Anesthesiologist's Initiative Reviewed

    NISHIWAKI Kimitoshi

    THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA   Vol. 37 ( 1 ) page: 59 - 66   2017

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    <p>Owing to recent advancements in surgical techniques and developments in perioperative patient care, greater numbers of surgeries are being performed worldwide. In order to reduce surgery-related deaths and complications, the World Health Organization(WHO)published the WHO Guidelines for Safe Surgery 2009. This article outlines global trends in patient safety in the perioperative period;summarized the WHO guidelines;describes Japanese efforts to follow the guidelines;and discusses the Helsinki Declaration on Patient Safety in Anesthesiology, which aims to ensure patient safety, especially in the field of anesthesiology by focusing on the WHO Guidelines for Safe Surgery 2009 and other protocols. The Helsinki Declaration was firstly ratified by the European Society of Anesthesiology, and then by many other bodies all over the world including the Japanese Society of Anesthesiologists.</p>

    DOI: 10.2199/jjsca.37.59

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  36. Observation of ultrasound-guided thoracic paravertebral block using thoracoscopy. Reviewed International journal

    Fujii T, Shibata Y, Nishiwaki K

    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists   Vol. 54 ( 3 ) page: 101 - 102   2016.9

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    DOI: 10.1016/j.aat.2016.05.004

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  37. Combination of Continuous Epidural Block and Rehabilitation in a Case of Complex Regional Pain Syndrome. Reviewed

    Hayashi K, Nishiwaki K, Kako M, Suzuki K, Hattori K, Sato K, Kadono I, Nishida Y

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   Vol. 83 ( 6 ) page: 262 - 267   2016

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    DOI: 10.1272/jnms.83.262

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  38. Comparison of kidney disease: improving global outcomes and acute kidney injury network criteria for assessing patients in intensive care units. Reviewed International journal

    Shinjo H, Sato W, Imai E, Kosugi T, Hayashi H, Nishimura K, Nishiwaki K, Yuzawa Y, Matsuo S, Maruyama S

    Clinical and experimental nephrology   Vol. 18 ( 5 ) page: 737 - 745   2014.10

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    DOI: 10.1007/s10157-013-0915-4

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  39. [WHO Surgical Safety Checklist and guideline for safe surgery 2009]. Reviewed

    Nishiwaki K, Ichikawa T

    Masui. The Japanese journal of anesthesiology   Vol. 63 ( 3 ) page: 246 - 54   2014.3

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  40. 「大量出血と輸液・輸血療法」によせて Reviewed

    西脇 公俊, 加藤 孝澄

    日本臨床麻酔学会誌   Vol. 34 ( 4 ) page: 538 - 538   2014

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  41. A prospective randomized multicenter comparative study of BLM-240 (desflurane) versus sevoflurane in Japanese patients. Reviewed International journal

    Takeda J, Namiki A, Ozaki M, Fukuda K, Morita K, Kanmura Y, Yamakage M, Komatsu T, Inada E, Kawate R, Kanazawa M, Sakamoto A, Uezono S, Sato S, Nishiwaki K, Miyamoto Y, Nakatsuka H, Yasuda N, Baxter BL, Study Team

    Journal of anesthesia   Vol. 27 ( 3 ) page: 468 - 471   2013.6

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  42. 「手術室の安全管理」によせて Reviewed

    西脇 公俊

    日本臨床麻酔学会誌   Vol. 33 ( 7 ) page: 884 - 884   2013

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  43. Different effects of dibutyryl cAMP on monolayer permeability in human aortic and coronary arterial endothelial cells Reviewed International journal

    Nan Yong-Shan, Li Shao-Yan, Kang Ji-Long, Suzuki Shogo, Ema Yoshiaki, Nishiwaki Kimitoshi

    AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH   Vol. 6 ( 5 ) page: 897 - 903   2012.2

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  44. Effects of midazolam, diazepam, propofol and dexmedetomidine on endothelial cell proliferation and angiogenesis induced by VEGF Reviewed International journal

    Nan Yong-Shan, Li Shao-Yan, Kang Ji-Long, Suzuki Shogo, Ema Yoshiaki, Nishiwaki Kimitoshi

    AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH   Vol. 4 ( 23 ) page: 2549 - 2555   2010.12

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  45. Significance of prevention and early treatment of a postoperative twisted neck : atlantoaxial rotatory subluxation after head and neck surgery Reviewed International journal

    KIM Byeoknyeon, IWATA Keiko, SUGIMOTO Kenji, SUZUKI Shogo, EMA Yoshiaki, TSUNOBUCHI Hironaka, NISHIWAKI Kimitoshi

    Journal of anesthesia   Vol. 24 ( 4 ) page: 598 - 602   2010.8

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  46. CLINICAL USE OF CRYOPRECIPITATE OR FIBRINOGEN CONCENTRATE TO PREVENT MASSIVE HEMORRHAGE DURING SURGERY Reviewed

    YAMAMOTO Koji, NISHIWAKI Kimitoshi, KATO Chiaki, HANAI Keiko, KIKUCHI Ryosuke, SHIBAYAMA Shuji, NAGINO Masato, KIUCHI Tetsuya, UEDA Yuichi, TAKAMATSU Junki

    Japanese Journal of Transfusion and Cell Therapy   Vol. 56 ( 1 ) page: 36 - 42   2010.2

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    <b>Background:</b> Massive hemorrhage during surgery often results from diluted coagulopathy due to loss of coagulation factors (e.g., fibrinogen), especially in cases of thoracic aortic aneurysm, liver transplantation, and hepatoma/perihilar cholangiocarcinoma. The most important issue in preventing massive hemorrhage during surgery is transfusion therapy for hemostasis. This study analyzed the hemostatic efficacy of cryoprecipitate or fibrinogen concentrate during surgery when massive bleeding occurred.<br> <b>Patients and Methods:</b> When massive hemorrhage occurred in cases of thoracic aortic aneurysm, liver transplantation, and hepatoma/perihilar cholangiocarcinoma, we measured the fibrinogen level in plasma, and administered cryoprecipitate or fibrinogen concentrate to the patient when the fibrinogen level was below 150mg/d<i>l</i>(in 2007&sim;2008). The hemostatic efficacy of this treatment was evaluated by counting the volume of blood loss and number of transfusion units in comparison with cases of treatment with fresh frozen plasma (in 2005&sim;2006).<br> <b>Results:</b> We observed a rapid increase in plasma fibrinogen level and subsequent improvement in hemostasis after cryoprecipitate or fibrinogen concentrate was administered. The average blood loss decreased by 30% and the average number of transfusion units was reduced about 30% to 60% when those agents were given to patients with severe hypofibrinogenemia during surgery. The number of cases of early death due to massive hemorrhage during surgery decreased by 75% in 2007&sim;2008 when fibrinogen concentrate was used.<br> <b>Conclusion:</b> In patients showing hypofibrinogenemia (i.e. <150mg/d<i>l</i>) during surgery, administration of fibrinogen concentrate should be effective in establishing hemostatsis, and therefore in reducing blood loss and transfusion volume. This treatment should help to improve the prognosis of patients in surgery, and also to decrease the use of blood products.<br>

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  47. Safe sedation management using volatile anesthetics during cardiopulmonary bypass Reviewed

    Tamura Takahiro, Mori Atsushi, Nishiwaki Kimitoshi

    JOURNAL OF ANESTHESIA   Vol. 36 ( 2 ) page: 287 - 293   2022.4

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    Several pieces of evidence suggest that volatile anesthetics (VAs), which were originally used as sedatives, have myocardial protective effects against cardiac ischemia–reperfusion injury. In Europe and the United States, the use of VAs during cardiopulmonary bypass (CPB) is widespread, as 2019 European Association for Cardio-Thoracic Surgery (EACTS)/European Association of Cardiothoracic Anaesthesiology/European Board of Cardiovascular Perfusion, 2011 American College of Cardiology/American Heart Association, and 2017 EACTS guidelines recommend their use in cardiovascular surgery, based on their potential myocardial protective effects. In other countries, including Japan, the use of VAs is gradually increasing. Therefore, it is important to be aware of the risks and possible adverse events associated with VA use during CPB to ensure safe sedation management. Herein, we describe in detail issues such as intraoperative awareness, air pollution, and damage to oxygenators due to VA use and propose precautions.

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  48. A Minimally Invasive Method for Observing Wind-Up of Flexion Reflex in Humans: Comparison of Electrical and Magnetic Stimulation Reviewed

    Taniguchi Tomoya, Kinukawa Tomoaki Alex, Takeuchi Nobuyuki, Sugiyama Shunsuke, Nishihara Makoto, Nishiwaki Kimitoshi, Inui Koji

    FRONTIERS IN NEUROSCIENCE   Vol. 16   page: 837340   2022.2

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    Wind-up like pain or temporal summation of pain is a phenomenon in which pain sensation is increased in a frequency-dependent manner by applying repeated noxious stimuli of uniform intensity. Temporal summation in humans has been studied by observing the increase in pain or flexion reflex by repetitive electrical or thermal stimulations. Nonetheless, because the measurement is accompanied by severe pain, a minimally invasive method is desirable. Gradual augmentation of flexion reflex and pain induced by repetitive stimulation of the sural nerve was observed using three stimulation methods—namely, bipolar electrical, magnetic, and monopolar electrical stimulation, with 11 healthy male subjects in each group. The effects of frequency, intensity, and number of repetitive stimuli on the increase in the magnitude of flexion reflex and pain rating were compared among the three methods. The reflex was measured using electromyography (EMG) from the short head of the biceps femoris. All three methods produced a frequency- and intensity-dependent progressive increase in reflex and pain; pain scores were significantly lower for magnetic and monopolar stimulations than for bipolar stimulation (P < 0.05). The slope of increase in the reflex was steep during the first 4–6 stimuli but became gentler thereafter. In the initial phase, an increase in the reflex during the time before signals of C-fibers arrived at the spinal cord was observed in experiments using high-frequency stimulation, suggesting that wind-up was caused by inputs of A-fibers without the involvement of C-fibers. Magnetic and monopolar stimulations are minimally invasive and useful methods for observing the wind-up of the flexion reflex in humans. Monopolar stimulation is convenient because it does not require special equipment. There is at least a partial mechanism underlying the wind-up of the flexion reflex that does not require C-fibers.

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  49. The equilibrated blood sevoflurane concentrations show a rapid decrease after switching from ventilation for the human lung to cardiopulmonary bypass Reviewed

    Tamura Takahiro, Mori Atsushi, Ishii Akira, Nishiwaki Kimitoshi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 1 ) page: 163 - 168   2022.2

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    Volatile anesthetics (VAs) protect myocardial cells during cardiovascular surgeries, including cardiopulmonary bypass (CPB). In CPB, blood is gradually transferred from the body to a CPB unit until the target cardiac index is achieved, following which human lung (HL) ventilation is stopped. This pilot study aimed to evaluate changes in the blood sevoflurane concentrations 5 min after the start of CPB when its delivery to the oxygenator began after HL ventilation with sevoflurane was completed. Six patients were recruited and participated in this study. For each patient, the equilibrated blood sample, collected 20 min after starting the delivery of 1.7% sevoflurane (HL group), and another blood sample, collected 5 min after starting the CPB, were analyzed using gas chromatography equipped with a flame ionization detector. The mean (± standard deviation) sevoflurane concentrations in the HL and 5 min after starting CPB groups were 58.6 ± 4.7 and 14.5 ± 5.0 μg/ml, respectively (P < 0.01). In conclusion, the equilibrated blood sevoflurane concentrations showed a rapid decrease when switching from sevoflurane ventilation for the HL to CPB unless it was introduced to the oxygenator until completion of the switch

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  50. Comparison of remimazolam and propofol in anesthetic management for awake craniotomy: a retrospective study Reviewed

    Sato Takehito, Nishiwaki Kimitoshi

    JOURNAL OF ANESTHESIA   Vol. 36 ( 1 ) page: 152 - 155   2022.2

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    A new ultra-short-acting benzodiazepine intravenous anesthetic agent, remimazolam, was launched in Japan in 2020. Anesthesia during awake craniotomy is reportedly being performed safely using remimazolam; however, studies on its efficacy in awake craniotomy have not been conducted. We aimed to compare the efficacy of remimazolam and propofol in awake craniotomy. In this retrospective study, patients who underwent awake craniotomy (n = 36) at our hospital between December 2019 and January 2021 were divided into two groups: the propofol group (P group: n = 21) and the remimazolam group (R group: n = 15). There was no significant difference in the recovery time between the two groups (p = 0.18). The number of patients experiencing nausea was higher in the R group than in the P group (p = 0.02); however, regression analysis revealed that the use of remimazolam contributed to increased intraoperative nausea (odds ratio = 14.4, p = 0.04). No significant differences were observed in the frequency of vomiting and other intraoperative complications between the two groups. In conclusion, remimazolam has the potential for use as an alternative drug in anesthetic management during awake craniotomy.

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  51. Ketamine reduces the dose of remifentanil required during prolonged head and neck surgery: a propensity-matched analysis Reviewed

    Fujii Tasuku, Nishiwaki Kimitoshi

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 84 ( 1 ) page: 1 - 6   2022.2

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    High-dose opioids induce hyperalgesia and tolerance, which negatively affects postoperative recovery.Prolonged surgery inevitably requires higher opioid doses. Ketamine reduces perioperative opioid consumptionand prevents opioid-induced tolerance. However, its effects in cases of prolonged surgery remainunknown. This study aimed to evaluate the dose of intraoperative remifentanil, an ultrashort-acting μ-opioidagonist, administered after an intravenous ketamine bolus during prolonged head and neck surgery. Thissingle-center, retrospective, observational study included 251 patients who underwent head and necksurgery (operation time ≥8 h) between January 2015 and December 2019. The participants were stratifiedinto two groups: those who received an intravenous bolus of ketamine and those who did not (ketaminegroup and non-ketamine group, respectively). Propensity score-matching was used to match patients in a1:1 ratio between the two groups, based on their covariates. The difference in intraoperative remifentanildose administered between the two groups was assessed. After 1:1 propensity score-matching, 89 matchedpatients were selected from each group. The mean ± standard deviation dose of remifentanil administeredwas significantly lower in the ketamine group than in the non-ketamine group before (0.15±0.05 vs0.17±0.05 μg/kg/min; P=0.01) and after matching (0.15±0.06 vs 0.17±0.05 μg/kg/min; P=0.03). In conclusion,intravenous ketamine administration may reduce the intraoperative dose of remifentanil requiredduring prolonged head and neck surgery. However, further studies are required to evaluate the effect ofthis finding on enhanced recovery after surgery

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  52. Peroneural neuropathy after total hip arthroplasty with combined neural block: a case report Reviewed

    KINUKAWA Tomoaki Alex, TAMURA Takahiro, TAKEGAMI Yasuhiko, SEKI Taisuke, NISHIWAKI Kimitoshi

    Journal of Japan Society of Pain Clinicians   Vol. 28 ( 9 ) page: 194 - 198   2021.9

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    <p>A 46-year-old woman, 157 cm 58 kg, underwent left total hip arthroplasty after lumbar plexus block and sciatic nerve block via the parasacral approach. Postoperative X-ray revealed 20-mm leg extension. After surgery, both legs had movement disorder and sensory disturbance, which improved within a few hours. Lumbar plexus block was considered to be an epidural block. Thereafter, sensory and motor disorders slightly improved, but recovery of dorsiflexion movement of the left ankle joint was delayed and mild peroneal neuropathy at the level of the peroneal head was diagnosed by electromyography 28 days after surgery. Thirty-two days after surgery, the patient was discharged with stable walking using a cane. The neurological symptoms were suspected to be caused by physical factors, such as hyperextension of the peroneal nerve, because the neuropathy was at the level of the peroneum. We also cannot exclude the possibility that this nerve block affected paralysis.</p>

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  53. Interference of a ventricular assist device with magnetic navigation during insertion of Sherlock 3CG (TM), a bedside peripherally inserted central catheter Reviewed

    Takakura Masashi, Fujii Tasuku, Suzuki Shogo, Nishiwaki Kimitoshi

    JOURNAL OF ARTIFICIAL ORGANS     2021.9

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    Recently, the Sherlock 3CG™ Tip Confirmation System, including a magnetic tracking system and an intracavitary electrocardiography guidance system, has been introduced for bedside peripherally inserted central catheter (PICC) insertion. Magnetic field sources interfere with the magnetic tracking system. Electromagnetic interference of the ventricular assist device (VAD) has already been reported with various devices but not on Sherlock 3CG™. We assessed the availability of the magnetic tracking system in patients with and without a VAD during Sherlock 3CG™ insertion and evaluated the rate of optimal PICC tip position. We retrospectively reviewed 99 patients who had undergone PICC insertion using Sherlock 3CG™ on the bedside at our institutional intensive care unit from February 2018 to December 2020. Patients were divided into groups with and without a VAD. The availability of magnetic navigation and the success rate of optimal catheter tip position in each group were assessed. Among 87 cases analyzed, there were 12 and 75 cases with a VAD and without a VAD, respectively. The availability of magnetic navigation during Sherlock 3CG™ insertion was significantly lower in the group with a VAD [4/12 (33%) with VAD vs. 72/75 (96%) without VAD, P < 0.001]. In addition, the rate of optimal PICC tip position was also significantly lower in the group with a VAD [6/12 (50%) vs. 63/75 (84%), P = 0.015] The VAD significantly led to magnetic tracking system failure due to its electromagnetic interference during Sherlock 3CG™ insertion and significantly reduced the success rate of PICC insertions in the optimal position.

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  54. A mouse model of microglia-specific ablation in the embryonic central nervous system. Reviewed

    Li C, Konishi H, Nishiwaki K, Sato K, Miyata T, Kiyama H

    Neuroscience research     2021.6

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    Microglia, which migrate into the central nervous system (CNS) during the early embryonic stages, are considered to play various roles in CNS development. However, their embryonic roles are largely unknown, partly due to the lack of an effective microglial ablation system in the embryo. Here, we show a microglial ablation model by injecting diphtheria toxin (DT) into the amniotic fluid of Siglechdtr mice, in which the gene encoding DT receptor is knocked into the microglia-specific gene locus Siglech. We revealed that embryonic microglia were depleted for several days throughout the CNS, including some regions where microglia transiently accumulated, at any embryonic time point from embryonic day 10.5, when microglia colonize the CNS. This ablation system was specific for microglia because CNS-associated macrophages, which are a distinct population from microglia that reside in the CNS interfaces such as meninges, were unaffected. Therefore, this microglial ablation system is highly effective for studying the embryonic functions of microglia.

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  55. Conditioned Pain Modulation: Comparison of the Effects on Nociceptive and Non-nociceptive Blink Reflex. Reviewed

    Kinukawa TA, Inui K, Taniguchi T, Takeuchi N, Sugiyama S, Nishihara M, Nishiwaki K, Kakigi R

    Neuroscience   Vol. 468   page: 168 - 175   2021.6

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    Although conditioned pain modulation (CPM) is considered to represent descending pain inhibitory mechanisms triggered by noxious stimuli applied to a remote area, there have been no previous studies comparing CPM between pain and tactile systems. In this study, we compared CPM between the two systems objectively using blink reflexes. Intra-epidermal electrical stimulation (IES) and transcutaneous electrical stimulation (TS) were applied to the right skin area over the supraorbital foramen to evoke a nociceptive or a non-nociceptive blink reflex, respectively, in 15 healthy males. In the test session, IES or TS were applied six times and subjects reported the intensity of each stimulus on a numerical rating scale (NRS). Blink reflexes were measured using electromyography (R2). The first and second sessions were control sessions, while in the third session, the left hand was immersed in cold water at 10 °C as a conditioning stimulus. The magnitude of the R2 blink and NRS scores were compared among the sessions by 2-way ANOVA. Both the NRS score and nociceptive R2 were significantly decreased in the third session for IES, with a significant correlation between the two variables; whereas, TS-induced non-nociceptive R2 did not change among the sessions. Although the conditioning stimulus decreased the NRS score for TS, the CPM effect was significantly smaller than that for IES (p = 0.002). The present findings suggest the presence of a pain-specific CPM effect to a heterotopic noxious stimulus.

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  56. Comparison between the effects of normal saline with and without heparin for the prevention and management of arterial catheter occlusion: a triple-blinded randomized trial Reviewed

    Tamura Takahiro, Kobayashi Eri, Kawaguchi Mariko, Matsuoka Yuki, Fujii Akiko, Ando Masahiko, Kubo Yoko, Imaizumi Takahiro, Miyagawa Yasuhiro, Inagaki Takayuki, Nishiwaki Kimitoshi

    JOURNAL OF ANESTHESIA     2021.5

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    Purpose: We aimed to compare the effects of saline with and without heparin on the catheter-occlusion rate and coagulation-related blood test results for the management of arterial catheters among patients admitted to a short-term intensive care unit postoperatively. Methods: This prospective, triple-blinded, randomized controlled study recruited patients aged 20–90 years scheduled to undergo radial arterial catheter insertion and postoperative intensive care unit admission between February and August 2019. Patients were randomly allocated to two groups (1:1 ratio) depending on the use of heparin: study (normal saline with heparin, 3000 units to 500 ml of normal saline) and control (normal saline without heparin) groups with arterial catheters. The allocated management method was employed immediately after intensive care unit admission. Occlusion assessment (every 12 h), arterial blood gas tests (every 6 h), and blood sample collection (every 24 h) were performed. The occlusion of arterial catheter was assessed using occlusion rate, and blood test results were assessed using a linear mixed model. Results: There were 147 patients in the arterial catheter groups. There were no significant differences in occlusion rates and changes in platelet counts and activated partial thromboplastin time between the groups with arterial (p = 0.98, 0.16, and 0.32, respectively) catheters during the first 6 days after intensive care unit admission. Conclusion: Normal saline with and without heparin showed similar efficiency for both the prevention of occlusion and the results of coagulation.

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  57. Surgical Site Infections and Inflammatory Reaction After Cardiac Surgery; Bedside Artificial Pancreas Versus Conventional Insulin Therapy: A Propensity Score-Matched Analysis. Reviewed

    Fujii T, Hirai T, Suzuki S, Nishiwaki K

    Journal of cardiothoracic and vascular anesthesia     2021.5

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    Objectives: Perioperative hyperglycemia is associated with poor postoperative recovery, including compromised immune function and increased risk of infection. A closed-loop glycemic control system (artificial pancreas) has demonstrated strict safe perioperative glycemic control without hypoglycemia risk. The authors hypothesized that the artificial pancreas would reduce surgical site infections (SSIs) and postoperative inflammatory reactions. This study aimed to assess the effect of the artificial pancreas on SSIs and C-reactive protein (CRP) levels after cardiac surgery. Design: A single-center retrospective, propensity score–matched analysis. Setting: A university hospital. Participants: In total, 295 patients who underwent cardiovascular surgery with cardiopulmonary bypass were included. Interventions: Patients were divided into two groups: artificial pancreas (target blood glucose: 120-150 mg/dL) and intravenous insulin infusion (conventional insulin therapy, target blood glucose: <200 mg/dL). Measurements and Main Results: The differences in the incidence of SSIs and CRP levels between the two groups were assessed. After 1:1 propensity score matching based on their covariates, 101 matched patients were selected from each group. The incidence of SSIs was reduced by 3%, 5% (conventional insulin therapy), and 2% (artificial pancreas), but the reduction was not statistically significant (p = 0.45). The postoperative maximum CRP level was significantly lower in the artificial pancreas group than in the conventional insulin therapy group, mean (standard deviation)14.53 (5.64) mg/dL v 16.57 (5.58) mg/dL; p = 0.01. Conclusions: The artificial pancreas did not demonstrate a significant reduction in the incidence of SSIs. However, the artificial pancreas was safe and suppressed postoperative inflammation compared with conventional insulin therapy.

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  58. Difficult Airway Management in a Patient With Nicolaides-Baraitser Syndrome Who Had a Small Jaw and Limited Mouth Opening Reviewed International journal

    Saori Taharabaru, DDS ; Takehito Sato, MD ; Kimitoshi Nishiwaki, MD, PHD

    Anesthsia Progress   Vol. 68 ( 1 ) page: 47 - 49   2021.4

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  59. Morphology, localization, and postnatal development of dural macrophages Reviewed International journal

    Sato Takehito, Konishi Hiroyuki, Tamada Hiromi, Nishiwaki Kimitoshi, Kiyama Hiroshi

    CELL AND TISSUE RESEARCH   Vol. 384 ( 1 ) page: 49 - 58   2021.4

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  60. Reply to the letter Reviewed International journal

    Tamura Takahiro, Mori Atsushi, Nishiwaki Kimitoshi

    JOURNAL OF ANESTHESIA   Vol. 35 ( 1 ) page: 164 - 164   2021.2

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  61. Impact of Perioperative Steroid Administration in Patients Undergoing Major Hepatectomy with Extrahepatic Bile Duct Resection: A Randomized Controlled Trial Reviewed International journal

    Onoe Shunsuke, Yokoyama Yukihiro, Ebata Tomoki, Igami Tsuyoshi, Mizuno Takashi, Yamaguchi Junpei, Watanabe Nobuyuki, Suzuki Shogo, Nishiwaki Kimitoshi, Ando Masahiko, Nagino Masato

    ANNALS OF SURGICAL ONCOLOGY   Vol. 28 ( 1 ) page: 121 - 130   2021.1

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  62. Non-linear regression analysis for estimating the intraoperative motor evoked potential recovery time after bolus neuromuscular blockade Reviewed International journal

    Tatsuoka Tetsuro, Fujii Tasuku, Furuhashi Takeshi, Nishiwaki Kimitoshi

    JOURNAL OF CLINICAL MONITORING AND COMPUTING     2020.10

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  63. Sizing of mitral annuloplasty rings using real-time three-dimensional transesophageal echocardiography and the difference between patients with and without recurrent mitral regurgitation: retrospective cohort study Reviewed International journal

    Fujii Tasuku, Yoshitani Kenji, Kanemaru Eiki, Nakai Michikazu, Nishimura Kunihiro, Ohnishi Yoshihiko, Nishiwaki Kimitoshi

    JOURNAL OF ECHOCARDIOGRAPHY   Vol. 18 ( 3 ) page: 169 - 174   2020.9

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  64. Difficult Airway Management in a Patient With Nicolaides-Baraitser Syndrome Who Had a Small Jaw and Limited Mouth Opening. Reviewed

    Taharabaru S, Sato T, Nishiwaki K

    Anesthesia progress   Vol. 68 ( 1 ) page: 47 - 49   2020.3

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  65. A single paravertebral injection via a needle vs. a catheter for the spreading to multiple intercostal levels: a randomized controlled trial.

    Fujii T, Shibata Y, Ban Y, Shitaokoshi A, Takahashi K, Matsui S, Nishiwaki K

    Journal of anesthesia   Vol. 34 ( 1 ) page: 72-78   2020.2

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  66. Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines

    Hirai Takahiro, Konishi Yuko, Mizuno Shoko, Rui Zhou, Sun Yao, Nishiwaki Kimitoshi

    JOURNAL OF ANESTHESIA   Vol. 34 ( 1 ) page: 47-57   2020.2

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  67. Correction to: Differential effects of sevoflurane on the growth and apoptosis of human cancer cell lines.

    Hirai T, Konishi Y, Mizuno S, Rui Z, Sun Y, Nishiwaki K

    Journal of anesthesia   Vol. 34 ( 1 ) page: 58   2020.2

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  68. A case of massive hepatic ischemia during perioperative period of subtotal stomach-preserving pancreaticoduodenectomy Reviewed

    Yamada Akihiro, Maeda Sho, Takeichi Hiromu, Adachi Yushi, Nishiwaki Kimitoshi

    Journal of the Japanese Society of Intensive Care Medicine   Vol. 27 ( 2 ) page: 113 - 114   2020

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    DOI: 10.3918/jsicm.27_113

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  69. A triple-blinded randomized trial comparing spinal morphine with posterior quadratus lumborum block after cesarean section Reviewed International journal

    Tamura T, Yokota S, Ando M, Kubo Y, Nishiwaki K

    INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA   Vol. 40   page: 32 - 38   2019.11

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    DOI: 10.1016/j.ijoa.2019.06.008

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  70. Retrospective investigation about anesthetic management of biliary atresia in children: laparoscopic versus conventional Kasai portoenterostomy

    Sato Takehito, Nishiwaki Kimitoshi

    JA CLINICAL REPORTS   Vol. 5 ( 1 ) page: 7   2019.2

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    DOI: 10.1186/s40981-019-0228-z

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  71. Difficult Airway Management in a Patient with Nicolaides-Baraitser Syndrome Who Had a Small Jaw and Limited Mouth Opening Reviewed

    TAHARABARU Saori, SATO Takehito, NISHIWAKI Kimitoshi

    Journal of Japanese Dental Society of Anesthesiology   Vol. 47 ( 3 ) page: 107 - 109   2019

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    <p>  Nicolaides-Baraitser syndrome (NCBRS) is a rare congenital genetic disorder characterized by specific facial features, distal limb malformations, and mental retardation. At present, there are no reports of anesthetic management in patients with NCBRS. We report the first case of a successful nasal fiberscopic intubation in a patient with NCBRS in whom intubation was difficult because of a prominent small jaw, restricted mouth opening, and sleep apnea. A 9-year-old girl who had been diagnosed as having NCBRS was scheduled to undergo the extraction of decayed teeth under general anesthesia. She had a medical history of a cleft palate revision at the age of 3 years. Because she had a small jaw and restricted mouth opening, intubation was performed using an Airwayscope<sup>®</sup> (AWS) during the previous anesthesia. First, we attempted oral intubation using an AWS after induction. After the administration of muscle relaxants, however, mouth opening was not possible. Therefore, we could not intubate using AWS or an oral fiberscope. Next, we tried nasal intubation using a bronchofiberscope. Despite an unclear visualization because of the presence of the adenoids and oral secretions, we were able to intubate the patient. There were no complications during the intubation, such as nose bleeding, and there were no problems in providing positive ventilation. The operation was completed without any adverse events. The postoperative course was not problematic, and she was discharged on the third day after surgery. Intubation might be difficult in patients with NCBRS ; therefore, the risk of a difficult airway should be evaluated during the anesthetic management of these patients.</p>

    DOI: 10.24569/jjdsa.47.3_107

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  72. Reply to Drs El-Boghdadly and Elsharkawy. Reviewed International journal

    Tamura T, Kitamura K, Yokota S, Ito S, Shibata Y, Adachi YU, Nishiwaki K

    Regional anesthesia and pain medicine   Vol. 43 ( 5 ) page: 558 - 559   2018.7

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    DOI: 10.1097/AAP.0000000000000815

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  73. A rise in the platelet count by HLA-antigen negative compatible platelet transfusion in a platelet anti-HLA antibody-positive patient Reviewed

    Mori R.

    Japanese Journal of Anesthesiology   Vol. 67 ( 6 ) page: 642 - 646   2018.6

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  74. A rise in the platelet count by HLA-antigen negative compatible platelet transfusion in a platelet anti-HLA antibody-positive patient Reviewed

    Mori R

    Japanese Journal of Anesthesiology   Vol. 67 ( 6 ) page: 642 - 646   2018.6

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  75. Clinical Utility of Intraoperative Motor-Evoked Potential Monitoring to Prevent Postoperative Spinal Cord Injury in Thoracic and Thoracoabdominal Aneurysm Repair: An Audit of the Japanese Association of Spinal Cord Protection in Aortic Surgery Database.

    Yoshitani K, Masui K, Kawaguchi M, Kawamata M, Kakinohana M, Kato S, Hasuwa K, Yamakage M, Yoshikawa Y, Nishiwaki K, Aoyama T, Inagaki Y, Yamasaki K, Matsumoto M, Ishida K, Yamashita A, Seo K, Kakumoto S, Hayashi H, Tanaka Y, Tanaka S, Ishida T, Uchino H, Kakinuma T, Yamada Y, Mori Y, Izumi S, Nishimura K, Nakai M, Ohnishi Y

    Anesthesia and analgesia     2017.12

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    DOI: 10.1213/ANE.0000000000002749

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  76. Important role of calcium chloride in preventing carbon monoxide generation during desflurane degradation with alkali hydroxide-free carbon dioxide absorbents.

    Ando T, Mori A, Ito R, Nishiwaki K

    Journal of anesthesia   Vol. 31 ( 6 ) page: 911-914   2017.12

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    DOI: 10.1007/s00540-017-2397-0

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  77. 症例検討 予期せぬICU入室 2 術中の大量出血-術後のプロブレムリストも解決しよう Reviewed

    平井 昂宏, 西脇 公俊

    LiSA   Vol. 24 ( 11 ) page: 1100 - 1106   2017.11

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    DOI: 10.11477/mf.3101200998

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  78. Efficacy of urinary midkine as a biomarker in patients with acute kidney injury.

    Hayashi H, Sato W, Kosugi T, Nishimura K, Sugiyama D, Asano N, Ikematsu S, Komori K, Nishiwaki K, Kadomatsu K, Matsuo S, Maruyama S, Yuzawa Y

    Clinical and experimental nephrology   Vol. 21 ( 4 ) page: 597-607   2017.8

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    DOI: 10.1007/s10157-016-1318-0

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  79. Two cases of autoimmune pulmonary alveolar proteinosis with rheumatoid arthritis.

    Ito S, Wakahara K, Kojima T, Takahashi N, Nishiwaki K, Yamaguchi E, Hasegawa Y

    Allergology international : official journal of the Japanese Society of Allergology   Vol. 66 ( 3 ) page: 507-509   2017.7

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    DOI: 10.1016/j.alit.2017.02.002

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  80. Rapid Fluid Infusion and Depth of Anesthesia.

    Adachi YU, Satomoto M, Nishiwaki K

    Anesthesiology   Vol. 126 ( 5 ) page: 985-986   2017.5

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    DOI: 10.1097/ALN.0000000000001577

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  81. A randomized controlled trial comparing paravertebral block via the surgical field with thoracic epidural block using ropivacaine for post-thoracotomy pain relief.

    Tamura T, Mori S, Mori A, Ando M, Yokota S, Shibata Y, Nishiwaki K

    Journal of anesthesia   Vol. 31 ( 2 ) page: 263-270   2017.4

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    DOI: 10.1007/s00540-017-2307-5

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  82. [Ultrasound-guided Truncal Block for Abdominal Surgery: Present and Future Perspectives].

    Shinya S, Shibata Y, Nishiwaki K

    Masui. The Japanese journal of anesthesiology   Vol. 66 ( 3 ) page: 255-262   2017.3

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  83. A randomized controlled trial comparing paravertebral block via the surgical field with thoracic epidural block using ropivacaine for post-thoracotomy pain relief Reviewed

    Takahiro TamuraShoichi MoriAtsushi MoriMasahiko AndoShuichi YokotaYasuyuki ShibataKimitoshi Nishiwaki

    Journal of Anesthesia     2017.1

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    DOI: 10.1007/s00540-017-2307-5

  84. Breakage and retention of thoracic paravertebral catheter: a case report

    Fujii Tasuku, Shibata Yasuyuki, Nishiwaki Kimitoshi

    JA CLINICAL REPORTS   Vol. 3 ( 1 ) page: 4   2017.1

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    DOI: 10.1186/s40981-016-0074-1

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  85. [Acute Subdural Hematoma due to the Breakage of an Epidural Catheter Left for a Long Time].

    Fujii T, Suzuki K, Shibata Y, Nishiwaki K

    Masui. The Japanese journal of anesthesiology   Vol. 66 ( 1 ) page: 65-69   2017.1

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  86. Intravenous cibenzoline improved the systolic anterior motion of the mitral valve after mitral valvuloplasty : a case report Reviewed

    Fujii Tasuku, Aoyama Tadashi, Ishida Yuki, Shinya Sonoe, Kainuma Motoshi, Nishiwaki Kimitoshi

    Cardiovascular Anesthesia   Vol. 21 ( 1 ) page: 69 - 74   2017

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    <p> In this case, hemodynamic collapse occurred due to the systolic anterior motion (SAM) of the mitral valve after a mitral valvuloplasty (MVP). Intravenous administration of cibenzoline, a sodium (Na<sup>+</sup>)-channel blocker, reduced left ventricular outflow tract (LVOT) obstruction and the mitral regurgitation (MR) resulting from the SAM, and the hemodynamic condition was improved.</p><p> SAM is a well-known complication after MVP. The Venturi effect created by increasing the blood flow velocity at the narrowed LVOT causes the anterior leaflet of the mitral valve to be drawn into the LVOT. Effective perioperative management suppresses the left ventricular contraction, and increases the pre-load and after-load. This requires discontinuation of inotropic drugs, administration of vasoconstrictors, and expansion of intravascular volume. Considering the pathogenesis of SAM, therapies for hypertrophic obstructive cardiomyopathy, such as a beta (β)-blocker, a calcium antagonist, or a Na<sup>+</sup>-channel blocker, can be effective for treatment of SAM after MVP. A short-acting β-blocker is convenient, and commonly used for the perioperative management of SAM. The essential cause of SAM after MVP is myocardial hypercontraction rather than tachycardia. A Na<sup>+</sup>-channel blocker is effective for attenuation of the left ventricular pressure gradient (LVPG) because it has more of a negative inotropic effect than a negative chronotropic effect. Therefore, we suggest that if a β-blocker is unavailable, or is insufficient for decreasing the LVPG, cibenzoline is effective for SAM after MVP.</p>

    DOI: 10.11478/jscva.2016-3-022

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  87. Severe consumptive coagulopathy caused by heparin-induced thrombocytopenia Reviewed

    Mizuno Shoko, Kainuma Motoshi, Nishiwaki Kimitoshi

    Journal of the Japanese Society of Intensive Care Medicine   Vol. 24 ( 1 ) page: 22 - 25   2017

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    A 69-year-old man suffered from sudden, severe back pain and was transported to our emergency room. An emergency Y-graft replacement was performed due to the rupture of an abdominal aortic aneurysm. We found a major thrombus in his right internal jugular vein by a CT scan performed on day 9, so we started the continuous intravenous infusion of heparin as thrombolytic therapy. On the same day, a hemodiafiltration circuit was frequently occluded by blood clots. The next day, the platelet count decreased to 40% compared with that the day before. We considered the possibility of heparin-induced thrombocytopenia (HIT) and immediately stopped administering heparin. On day 11, HIT antibodies with a high titer were detected. Then, we continuously administered argatroban. However, we had no choice but to decrease its dosage and finally stopped its administration after five days because of a prolonged APTT. The patient developed multiple organ dysfunction syndrome and died on day 59. We think that this case could have involved HIT accompanied by consumptive coagulopathy. The administration of argatroban is the only approved treatment for HIT in Japan. The dosage of argatroban has to be set according to the APTT. When a patient suffers a tendency for bleeding or a prolonged APTT, there is no choice but to reduce its dosage or stop its administration. There is no established therapy for HIT-associated consumptive coagulopathy.

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  88. Combination of Continuous Epidural Block and Rehabilitation in a Case of Complex Regional Pain Syndrome Reviewed

    Hayashi Kazuhiro, Nishiwaki Kimitoshi, Kako Masato, Suzuki Kentaro, Hattori Keiko, Sato Koji, Kadono Izumi, Nishida Yoshihiro

    JOURNAL OF NIPPON MEDICAL SCHOOL   Vol. 83 ( 6 ) page: 262 - 267   2016.12

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  89. Pain-reducing anesthesia prevents oxidative stress in human term placenta. Reviewed International journal

    Tsuzuki Y, Yamashita Y, Hattori Y, Hua Li G, Akatsuka S, Kotani T, Kikkawa F, Naiki-Ito A, Takahashi S, Nishiwaki K, Toyokuni S

    Journal of clinical biochemistry and nutrition   Vol. 58 ( 2 ) page: 156 - 160   2016.3

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    DOI: 10.3164/jcbn.15-138

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  90. 症例検討 薬をめぐるトラブル < 後編 > 麻酔導入後の治療抵抗性の低血圧-慌てず騒がず理論的に Reviewed

    平井 昂宏, 西脇 公俊

    LiSA   Vol. 23 ( 3 ) page: 254 - 258   2016.3

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    DOI: 10.11477/mf.3101200524

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  91. Delayed Onset of Subdural Hematoma following Epidural Catheter Breakage. Reviewed International journal

    Ishikawa Y, Imagama S, Ito Z, Ando K, Gotoh M, Nishiwaki K, Nagao Y, Ishiguro N

    Global spine journal   Vol. 6 ( 1 ) page: E1 - E6   2016.2

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    DOI: 10.1055/s-0035-1549030

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  92. Rhabdomyolysis due to propofol infusion syndrome after aortic surgery: a case report Reviewed

    Hirai Takahiro, Kainuma Motoshi, Hayashi Tomoko, Hasegawa Kazuko, Aoyama Tadashi, Mizuno Shoko, Suzuki Shogo, Nishiwaki Kimitoshi

    Journal of the Japanese Society of Intensive Care Medicine   Vol. 23 ( 6 ) page: 647 - 650   2016

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    Propofol infusion syndrome (PRIS) is a fatal syndrome associated with continuous propofol infusion, which causes several serious clinical conditions such as rhabdomyolysis, acute kidney injury (AKI), lactic acidosis, and hyperlipidemia. We report the case of a 44-year-old adult male patient suspected of having PRIS who was successfully treated by promptly discontinuing propofol infusion. The patient underwent total arch replacement for Stanford type A aortic dissection. Propofol was used for postoperative sedation, but his serum CK level was elevated up to 15,247 IU/<I>l</I>. He also developed AKI and lactic acidosis. Therefore, we strongly suspected PRIS, so propofol was discontinued. His serum CK level subsequently decreased, and AKI and lactic acidosis improved rapidly. CT scan showed some high-density areas in the hip and femoral muscles, which can be considered post-rhabdomyolysis changes. Serum CK, pH, and lactate levels should be measured routinely during prolonged propofol infusion, and alternative sedatives should be administered promptly if PRIS is suspected.

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  93. Nerve blocks for cancer pain Reviewed

      Vol. 70 ( 13 ) page: 1500 - 1508   2015.12

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    DOI: 10.11477/mf.1407211022

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  94. Radial artery cannulation decreases the distal arterial blood flow measured by power Doppler ultrasound. Reviewed International journal

    Numaguchi A, Adachi YU, Aoki Y, Ishii Y, Suzuki K, Obata Y, Sato S, Nishiwaki K, Matsuda N

    Journal of clinical monitoring and computing   Vol. 29 ( 5 ) page: 653 - 657   2015.10

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    DOI: 10.1007/s10877-014-9648-5

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  95. 学童期のMenkes病患者に対し全身麻酔を施行した一例 Reviewed

    佐藤 威仁, 西脇 公俊

    蘇生: 日本蘇生学会雑誌   Vol. 34 ( 3 ) page: 282a - 282a   2015

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    DOI: 10.11414/jjreanimatology.34.3_282a

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  96. [WHO Surgical Safety Checklist and guideline for safe surgery 2009]. Reviewed

    Nishiwaki K, Ichikawa T

    Masui. The Japanese journal of anesthesiology   Vol. 63 ( 3 ) page: 246 - 54   2014.3

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  97. WHO surgical safety checklist and guideline for safe surgery 2009 Reviewed

    Nishiwaki K., Ichikawa T.

    Japanese Journal of Anesthesiology   Vol. 63 ( 3 ) page: 246 - 254   2014.3

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    The World Health Organization WHO launched the Safe Surgery Saves Lives campaign in 2007 to improve safety of surgical care in the world. As a part of the campaign, the first edition of the Surgical Safety Checklist was created through an international consultative process in 2008 and the second edition was published in the WHO Guidelines for Safe Surgery 2009. The guidelines consist of ten essential objectives for safe surgery, and nine of the ten objectives are facilitated by introducing the surgical checklist in the operating room, which is designed to improve teamwork of the operating room member and to give them chances to use the safety processes consistently. It consists of nineteen check points scheduled to be used in three phases : before anesthesia induction, before any skin incisioa and at the end of surgery. In this article we gave an outline of WHO Surgical Safety Checklist and WHO Guidelines for Safe Surgery 2009, and reviewed the evidence of the guidelines and checklist Finally we presented the evidence indicating the efficacy of the WHO Surgical Safety Checklist, which included the pilot study attached in the guidelines showing that its use markedly decreased complications in patients undergoing noncardiac surgery in eight diverse international hospitals.

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  98. Dexmedetomidine-induced atrioventricular block followed by cardiac arrest during atrial pacing: a case report and review of the literature. Reviewed International journal

    Takata K, Adachi YU, Suzuki K, Obata Y, Sato S, Nishiwaki K

    Journal of anesthesia   Vol. 28 ( 1 ) page: 116 - 120   2014.2

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    DOI: 10.1007/s00540-013-1676-7

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  99. 症例検討 術中の低酸素血症2 気管挿管中の脳出血患者に対する気管切開術-急変は突然やってくる? Reviewed

    石田 祐基, 西脇 公俊

    LiSA   Vol. 21 ( 1 ) page: 38 - 42   2014.1

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    DOI: 10.11477/mf.3101102022

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  100. 重症心不全に対し集中治療を施行し補助人工心臓を装着した10症例の検討 Reviewed

    貝沼 関志, 西脇 公俊, 石田 祐基, 長谷川 和子, 林 智子, 平井 昴宏, 水野 祥子, 市川 崇, 青山 正, 鈴木 章悟

    蘇生: 日本蘇生学会雑誌   Vol. 33 ( 3 ) page: 177b - 177b   2014

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    DOI: 10.11414/jjreanimatology.33.177b

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  101. Intravenous droperidol decreases the bispectral index during general anesthesia with sevoflurane and remifentanil. Reviewed

    Adachi YU, Tanaka K, Suzuki S, Nishiwaki K, Matsuda N

    Masui. The Japanese journal of anesthesiology   Vol. 62 ( 1 ) page: 71 - 4   2013.1

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  102. 名大外科系集中治療部での体外式補助人工心臓長期管理6症例の検討 Reviewed

    貝沼 関志, 西脇 公俊, 長柄 祐輝, 水野 祥子, 尾関 奏子, 萩原 伸昭, 青山 正, 市川 崇, 鈴木 章悟, 高橋 英夫

    蘇生: 日本蘇生学会雑誌   Vol. 32 ( 3 ) page: 186b - 186b   2013

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    DOI: 10.11414/jjreanimatology.32.186b

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  103. WHO手術安全のガイドライン Reviewed

    西脇 公俊

    臨床麻酔   Vol. 37   page: 19 - 26   2013

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  104. [ECG changes after the induction of general anesthesia with remifentanil: a report of three case]. Reviewed

    Tanaka K, Adachi Y, Suzuki S, Nishiwaki K, Matsuda N

    Masui. The Japanese journal of anesthesiology   Vol. 61 ( 10 ) page: 1128 - 32   2012.10

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  105. Introduction of Postoperative Cases in Which Diagnosis and Treatment were Difficult in ICU Reviewed

    KAINUMA Motoshi, ICHIKAWA Takashi, KIM Byeoknyeon, NISHIWAKI Kimitoshi

      Vol. 32 ( 4 ) page: 507 - 512   2012.7

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  106. SF-046-5 敗血症性DICに対するアンチトロンビン製剤とトロンボモジュリン製剤の使用戦略(SF-046 サージカルフォーラム(46)救急 治療,第112回日本外科学会定期学術集会) Reviewed

    真弓 俊彦, 鈴木 秀一, 小野寺 睦雄, 市川 崇, 都築 通孝, 金 碧年, 高橋 英夫, 貝沼 関志, 西脇 公俊, 松田 直之

    日本外科学会雑誌   Vol. 113 ( 2 )   2012.3

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  107. Perioperative cerebral infarction required re-intubation twice: a case report Reviewed

    Adachi Yushi, Ichikawa Takashi, Kainuma Motoshi, Nishiwaki Kimitoshi, Yamamoto Takanori, Matsuda Naoyuki

    Journal of the Japanese Society of Intensive Care Medicine   Vol. 19 ( 4 ) page: 699 - 700   2012

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  108. 術前・術後管理必携 無機肺 Reviewed

    西脇 公俊

    消化器外科   Vol. 4   page: 856 - 858   2012

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  109. 気管挿管後に直達喉頭鏡刺激で高度徐脈を呈した1例 Reviewed

    西脇 公俊

    臨床麻酔   Vol. 36   page: 963 - 964   2012

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  110. Spinal cord stimulation markedly ameliorated refractory neuropathic pain in transthyretin Val30Met familial amyloid polyneuropathy. Reviewed International journal

    Miyazaki Y, Koike H, Akane A, Shibata Y, Nishiwaki K, Sobue G

    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis   Vol. 18 ( 2 ) page: 87 - 90   2011.6

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    DOI: 10.3109/13506129.2011.569782

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  111. LEVELS OF ANTITHROMBIN ACTIVITY AFTER ANTITHROMBIN ADMINISTRATION INDICATE PROGNOSIS OF SEPTIC DIC PATIENTS Reviewed International journal

    Mayumi T., Suzuki S., Yamamoto T., Ichikawa T., Onodera M., Tsuzuki M., Kin B., Inoue T., Kainuma M., Takahashi H., Matsuda N., Nishiwaki K.

    SHOCK   Vol. 35   page: 13 - 13   2011.6

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  112. 肺血管透過性亢進のメカニズムと麻酔薬の影響ー神経原生肺水腫から Reviewed

    西脇 公俊

    Anesthesia Network   Vol. 15(2)   page: 34 - 36   2011

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  113. Effects of midazolam, diazepam, propofol and dexmedetomidine on endothelial cell proliferation and angiogenesis induced by VEGF Reviewed International journal

    Nan Yong-Shan, Li Shao-Yan, Kang Ji-Long, Suzuki Shogo, Ema Yoshiaki, Nishiwaki Kimitoshi

    AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH   Vol. 4 ( 23 ) page: 2549 - 2555   2010.12

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  114. A randomized comparison of ultrasound guided thoracic para vertebral block and epidural analgesia for post-thoracotomy pain relief and respiratory function Reviewed International coauthorship International journal

    Aly H.M.

    Egyptian Journal of Anaesthesia   Vol. 26 ( 3 ) page: 189 - 198   2010.12

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    Scopus

  115. Adding fentanyl to the continuous infusion in lumbar plexus block: Is there a difference? Reviewed International journal

    Abd El-Ghany F.I.

    Egyptian Journal of Anaesthesia   Vol. 26 ( 3 ) page: 167 - 174   2010.12

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    Scopus

  116. A randomized comparison of ultrasound guided thoracic para vertebral block and epidural analgesia for post-thoracotomy pain relief and respiratory function Reviewed International coauthorship International journal

    Aly H.M

    Egyptian Journal of Anaesthesia   Vol. 26 ( 3 ) page: 189 - 198   2010.12

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  117. Significance of prevention and early treatment of a postoperative twisted neck : atlantoaxial rotatory subluxation after head and neck surgery Reviewed International journal

    KIM Byeoknyeon, IWATA Keiko, SUGIMOTO Kenji, SUZUKI Shogo, EMA Yoshiaki, TSUNOBUCHI Hironaka, NISHIWAKI Kimitoshi

    Journal of anesthesia   Vol. 24 ( 4 ) page: 598 - 602   2010.8

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  118. [Prevention of catheter-related bloodstream infections in the operation room]. Reviewed

    Ema Y, Nishiwaki K

    Masui. The Japanese journal of anesthesiology   Vol. 59 ( 5 ) page: 577 - 84   2010.5

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    PubMed

  119. Prevention of catheter-related bloodstream infections in the operation room Reviewed

    Ema Y., Nishiwaki K.

    Japanese Journal of Anesthesiology   Vol. 59 ( 5 ) page: 577 - 584   2010.5

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    Catheter-related bloodstream infections (CRBSIs) are recognized as an important and serious problem, especially in an intensive care unit (ICU), since they have far higher infection rates compared to those for other type of intravascular devices. However, in the operation room, there seems to be little concern among anesthesiologists regarding this problem. It is important for anesthesiologists to understand that CRBSIs can be prevented or reduced by evidence-based interventions such as hand hygiene, education in hand washing and alcohol-based hand rubbing, sterile catheter care techniques, proper skin disinfection, maximal barrier precautions during catheter insertion, choice of subclavian vein placement, avoidance of femoral vein placement, and removal of an unnecessary catheter. This evidence is based mainly on findings in ICU patients, but introduction of these interventions into operation rooms may be very useful for reducing perioperative CRBSIs.

    Scopus

  120. CLINICAL USE OF CRYOPRECIPITATE OR FIBRINOGEN CONCENTRATE TO PREVENT MASSIVE HEMORRHAGE DURING SURGERY Reviewed

    YAMAMOTO Koji, NISHIWAKI Kimitoshi, KATO Chiaki, HANAI Keiko, KIKUCHI Ryosuke, SHIBAYAMA Shuji, NAGINO Masato, KIUCHI Tetsuya, UEDA Yuichi, TAKAMATSU Junki

      Vol. 56 ( 1 ) page: 36 - 42   2010.2

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  121. 神経原生肺水腫と神経性肺血管透過性調節 Reviewed

    西脇 公俊

    別冊・医学のあゆみ最新ARDSのすべて     page: 200 - 205   2010

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  122. Ultrasound-guided intercostal approach to thoracic paravertebral block.

    Shibata Y, Nishiwaki K

    Anesthesia and analgesia   Vol. 109 ( 3 ) page: 996-7   2009.9

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    DOI: 10.1213/ane.0b013e3181af7e7b

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  123. Preliminary measurement of intraoperative sympathetic nerve activity using microneurography and laser Doppler flowmetry during surgical resection of suprasellar tumors.

    Kurimoto F, Saito K, Watanabe T, Nagatani T, Nishiwaki K, Wakabayashi T, Iwase S

    Neurologia medico-chirurgica   Vol. 49 ( 1 ) page: 13-21   2009.1

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  124. A greater decrease in blood pressure after spinal anaesthesia in patients with low entropy of the RR interval. Reviewed

    Fujiwara Y, Sato Y, Shibata Y, Asakura Y, Nishiwaki K, Komatsu T.

    Acta Anaesthesiol Scand.   Vol. 51 ( 9 ) page: 1161-5   2007.10

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  125. Possible roles of neuropeptide Y Y3-receptor subtype in rat aortic endothelial cell proliferation under hypoxia, and its specific signal transduction.

    Chen ZY, Feng GG, Nishiwaki K, Shimada Y, Fujiwara Y, Komatsu T, Ishikawa N

    American journal of physiology. Heart and circulatory physiology   Vol. 293 ( 2 ) page: H959-67   2007.8

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    DOI: 10.1152/ajpheart.00886.2006

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  126. Preoperative ultra short-term entropy predicts arterial blood pressure fluctuation during the induction of anesthesia.

    Fujiwara Y, Ito H, Asakura Y, Sato Y, Nishiwaki K, Komatsu T

    Anesthesia and analgesia   Vol. 104 ( 4 ) page: 853-6   2007.4

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    DOI: 10.1213/01.ane.0000258756.41649.2d

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  127. Correlation between heart rate variability and haemodynamic fluctuation during induction of general anaesthesia: comparison between linear and non-linear analysis.Anaesthesia. Reviewed

    Fujiwara Y, Kurokawa S, Asakura Y, Wakao Y, Nishiwaki K, Komatsu T.

    Anaesthesia.   Vol. 62 ( 2 ) page: 117-21   2007.2

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  128. Pediatric anesthesia practice and training in Japan: a survey.

    Shimada Y, Nishiwaki K, Sato K, Sato E, Miyasaka K

    Paediatric anaesthesia   Vol. 16 ( 5 ) page: 543-7   2006.5

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    DOI: 10.1111/j.1460-9592.2005.01817.x

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  129. A marked decrease in heart rate variability associated with junctional rhythmduring anesthesia with sevoflurane and fentanyl. Reviewed

    Fujiwara Y, Asakura Y, Shibata Y, Nishiwaki K, Komatsu T.

    Acta Anaesthesiol Scand.   Vol. 50 ( 4 ) page: 509-511   2006.4

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  130. Different effects of optical isomers of the 5-HT1A receptor antagonistpyrapyridolol against postischemic guinea-pig myocardial dysfunction andapoptosis through the mitochondrial permeability transition pore. Reviewed

    Huang L, Hotta Y, Miyazeki K, Ishikawa N, Miki Y, Sugimoto Y, Yamada J,Nakano A, Nishiwaki K, Shimada Y.

    Eur J Pharmacol.   Vol. 18 ( 534 ) page: 165-177   2006.3

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  131. *Opposing effects of isoflurane and sevoflurane on neurogenic pulmonary edema development in an animal model. Reviewed

    Kandatsu N, Nan YS, Feng GG, Nishiwaki K, Hirokawa M, Ishikawa K, Komatsu T,Yokochi T, Shimada Y, Ishikawa N.

    Anesthesiology.   Vol. 102 ( 6 ) page: 1182-9   2005.6

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  132. Severe hypertension after stellate ganglion block. Reviewed

    Kimura T, Nishiwaki K, Yokota S, Komatsu T, Shimada Y.

    Br J Anaesth.   Vol. 94 ( 6 ) page: 840-842   2005.6

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  133. Opposing effects of isoflurane and sevoflurane on neurogenic pulmonary edema development in an animal model.

    Kandatsu N, Nan YS, Feng GG, Nishiwaki K, Hirokawa M, Ishikawa K, Komatsu T, Yokochi T, Shimada Y, Ishikawa N

    Anesthesiology   Vol. 102 ( 6 ) page: 1182-9   2005.6

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  134. [A case of spontaneous intracranial hypotension effectively treated with cervical epidural blood patch].

    Asano N, Taki K, Kondo T, Nishiwaki K, Kimura T, Shimada Y

    Masui. The Japanese journal of anesthesiology   Vol. 53 ( 10 ) page: 1185-8   2004.10

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  135. A role for L-glutamate ionotropic receptors in the development of rat neurogenic pulmonary edema. Reviewed

    Kondo H, Feng GG, Nishiwaki K, Shimada Y, Hirokawa M, Komatsu T, Yokochi T,Ishikawa N.

    Eur J Pharmacol.   Vol. 24 ( 499 ) page: 257-263   2004.9

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  136. Neuropeptide Y enhances permeability across a rat aortic endothelial cell monolayer.

    Nan YS, Feng GG, Hotta Y, Nishiwaki K, Shimada Y, Ishikawa A, Kurimoto N, Shigei T, Ishikawa N

    American journal of physiology. Heart and circulatory physiology   Vol. 286 ( 3 ) page: H1027-33   2004.3

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    DOI: 10.1152/ajpheart.00630.2003

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  137. Is massive transfusion of fresh frozen plasma necessary in extensive hepatectomy? Reviewed

    KOBAYASHOI M, NISHIWAKI K, TAKAHASHI T, KOBAYASHOI M, NISHIWAKI K, TAKAHASHI T,FUJIWARA Y, KIMURA T, SHIMADA Y

    Anesth & Resuscitation   Vol. 40 ( 1 ) page: 39-42   2004

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  138. *Neuropeptide Y enhances permeability across a rat aortic endothelial cell monolayer. Reviewed

    NAN YS, FENG GG, HOTTA Y, NISHIWAKI K, SHIMADA Y, ISHIKAWA A, KURIMOTO N, SHIGEI T, ISHIKAWA N

    Am J PhysiolAm J Physiol Heart Circ Physiol   Vol. 286 ( 3 ) page: H1027-33   2004

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  139. Severe bradycardia in a patient undergoing endovascular stent-graft repair for abdominal aortic aneurysm with vena cava balloon occlusion. Reviewed

    SATO Y, KIMURA T, SATO E, NISHIWAKI K, SHIMADA Y

    Can J Anaesth   Vol. 50 ( 9 ) page: 970-1   2003

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  140. Inhibition of fibrin-induced neurogenic pulmonary edema by previous unilateral left-vagotomy correlates with increased levels of brain nitric oxide synthase in the nucleus tractus solitarii of rats.

    Feng GG, Nishiwaki K, Kondo H, Shimada Y, Ishikawa N

    Autonomic neuroscience : basic & clinical   Vol. 102 ( 1-2 ) page: 1-7   2002.11

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  141. Heart rate variability and arterial blood pressure variability show different characteristic changes during hemorrhage in isoflurane-anesthetized, mechanically ventilated dogs.

    Kawase M, Komatsu T, Nishiwaki K, Kobayashi M, Kimura T, Shimada Y

    Anesthesia and analgesia   Vol. 94 ( 1 ) page: 16-21, table of contents   2002.1

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  142. Heart rate variability and arterial blood pressure variability show different characteristic changes during hemorrhage in isoflurane-anesthetized, mechanically ventilated dogs. Reviewed

    KAWASE M, KOMATSU T, NISHIWAKI K, KOBAYASHI M,KAWASE M, KOMATSU T, NISHIWAKI K, KOBAYASHI M,KAWASE M, KOMATSU T, NISHIWAKI K, KOBAYASHI M, KIMURA T, SHIMADA Y

    Anesth Analg   Vol. 94 ( 1 ) page: 16-21   2002

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  143. Perioperative management of a patient with purpura fulminans syndrome due to protein C deficiency. Reviewed

    KUMAGAI K, NISHIWAKI K, SATO K, KITAMURA H, YANO K, KOMATSU T, SHIMADA Y

    Can J Anaesth   Vol. 48 ( 11 ) page: 1070-4   2001

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  144. Angiotensin-converting enzyme gene polymorphism in patients with neuropathic pain. Reviewed

    KIMURA T, KOMATSU T, HOSODA R. NISHIWAKI K, SHIMADA Y

    Prog Pain Res Manage   Vol. 16   page: 471-6   2000

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  145. Unilateral pulmonary cystic enlargement in a newborn: remember the one sided blind intubation. Reviewed

    KUMAGAI K, NISHIWAKI K, SATO K, KITAMURA H,YANO K, ONISHI S, SHIMADA Y

    Paediatr Anaesth   Vol. 10 ( 1 ) page: 111-3   2000

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  146. *Presence and quantification of neuropeptide Y in pulmonary edema fluid in rats. Reviewed

    HAMDY O, NISHIWAKI K, YAJIMA M, MURAKAMI HO, MAEKAWA H, MOY RT, SHIMADA Y, ISHIKAWA N

    Exp Lung Res   Vol. 26 ( 3 ) page: 137-47   2000

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  147. Heart rate variability during massive hemorrhage and progressive hemorrhagic shock in dogs. Reviewed

    KAWASE M, KOMATSU T, NISHIWAKI K, KIMURA T, FUJIWARA Y, TAKAHASHI T, SHIMADA Y

    Can J Anaesth   Vol. 47 ( 8 ) page: 807-814   2000

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  148. *Unexpected hyperkalemia following succinylcholin administration in prolonged immobilized parturients treated with magnesium and ritodrine. Reviewed

    SATO K, NISHIWAKI K, KUNO N, KUMAGAI K, KITAMURA H, YANO K, KOMATSU T, SHIMADA Y

    Anesthesiology   Vol. 93 ( 6 ) page: 1539-41   2000

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  149. Transfer function analysis of the circulation in patients undergoing sevoflurane anesthesia. Reviewed

    FUJIWARA Y, KOMATSU T, KIMURA T, KAWASE M, NISHIWAKI K, SHIMADA Y

    Can J Anaeth   Vol. 46   page: 820-26   1999

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  150. Heart rate and blood pressure power spectral analysis during calcium channel blocker induced hypotension. Reviewed

    KIMURA T, ITO M, KOMATSU T, NISHIWAKI K, SHIMADA Y

    Can J Anaesth   Vol. 46 ( 12 ) page: 1110-6   1999

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  151. Pretretment with topical 60% lidocaine tape reduces pain on injection of propofol. Reviewed

    YOKOTA S, KOMATSU T, KOMURA Y, NISHIWAKI K, KIMURA T, HOSODA R, SHIMADA Y

    Anesth Analg   Vol. 85   page: 672-74   1997

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  152. Recovery of heart rate variability profile in patients after coronary artery surgery. Reviewed

    KOMATSU T, KIMURA T, NISHIWAKI K, FUJIWARA Y, SAWADA K, SHIMADA Y

    Anesth Analg   Vol. 85   page: 713-18   1997

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  153. No changes in cerebrospinal fluid levels of nitrite, nitrate and cyclic GMP with aging. Reviewed

    YAMADA K, NISHIWAKI K, HATTORI K,SENZAKI K, NAGATA M, KOMATSU T,SHIMADA Y, NABESHIMA T.

    J Neural Transm   Vol. 104   page: 825-31   1997

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  154. Role of neuropeptide Y and its receptor subtype in the neurogenic pulmonary edema. Reviewed

    HIRABAYASHI A, NISHIWAKI K, SHIMADA Y, ISHIKAWA N

    Eur J Pharmacol   Vol. 296   page: 297-305   1996

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  155. Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia. Reviewed

    YAMADA K, KUNO K, UMEGAKI H, YAMADA K, IGUCHI A, FUKATSU T, NAKASHIMA N, NISHIWAKI K, SHIMADA Y,SUGITA Y, YAMAMOTO T, HASEGAWA T, NABESHIMA T

    NeuroscienceLetters   Vol. 186   page: 219-21   1995

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  156. Differential effects of ketamine and midazolam on heart-rate-variability. Reviewed

    KOMATU T, SINGH PK, KIMURA T, NISHIWKI K, BANDO K, SIMADA Y

    Can J Anaesth   Vol. 42   page: 1003-09   1995

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  157. Effects of vasodilators on fibrin-induced pulmonary edema, so-called neurogenic pulmonary edema, in the rat.

    Nishiwaki K, Hirabayashi A, Shimada Y, Ishikawa N

    Journal of anesthesia   Vol. 8 ( 2 ) page: 208-212   1994.6

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    DOI: 10.1007/BF02514715

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  158. Effects of vasodilators on fibrin induced pulmonary edema, so-called neurogenic pulmonary edema, in the rat. Reviewed

    NISHIWAKI K, HIRABAYASHI A, SHIMADA Y, ISHIKAWA N

    J Anesth   Vol. 8   page: 208-12   1994

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  159. Effects of neuropeptide Y on lung vascular permeability in the pulmonary circulation of rats. Reviewed

    HIRABAYASHI A, NISHIWAKI K, TAKI K,SHIMADA Y, ISHIKAWA N

    Eur J Pharmacol   Vol. 256   page: 227-30   1994

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  160. Humoral pulmonary vasoregulation in conscious dogs after left lung autotransplantaion. Reviewed

    DESAI PM, NISHIWAKI K, STUART RS, NYHAN DP, MURRAY PA

    J Appl Physiol   Vol. 76 ( 2 ) page: 902-8   1994

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  161. Prolonged pulmonary vascular hyperreactivity in conscious dogs after cardiopulmonary bypass. Reviewed

    NYHAN DP, REDMOND JM, GILLINOV AM, NISHIWAKI K, MURRAY PA

    J Appl Physiol   Vol. 77 ( 4 ) page: 1584-90   1994

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  162. Pulmonary vascular α1-adrenoreceptor activity in conscious dogs after left lung autotransplantation. Reviewed

    NISHIWAKI K, NYHAN DP, STUART SR, DESAI PM, PETERSON WP, ROCK P, PRIBBLE CG, MURRAY PA

    J Appl Physiol   Vol. 74 ( 2 ) page: 733-41   1993

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  163. Abnormal responses to pulmonary vasodilators in conscious dogs after left lung autotransplantation. Reviewed

    NISHIWAKI K, NYHAN DP, STUART SR, ROCK P, DESAI PM, PETERSON WP, MURRAY PA

    Am J Physiol   Vol. 264   page: H917-25   1993

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  164. Pulmonary vascular β-adrenoreceptor activity in conscious dogs after left lung autotransplantation. Reviewed

    NISHIWAKI K, ROCK P, STUART SR, NYHAN DP, PETERSON WP, MURRAY PA

    J Appl Physiol   Vol. 75 ( 1 ) page: 256-63   1993

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  165. Neurohumoral regulation of the pulmonary circulation during circulatory hypotension in conscious dogs. Reviewed

    PETERSON WP, TREMPY GA, NISHIWAKI K, NYHAN DP, MURRY PA

    J Appl Physiol   Vol. 75 ( 4 ) page: 1675-82   1993

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  166. Amrinone and the pulmonary vascular pressure-flow relationship in conscious control dogs and following left lung autotransplantation. Reviewed

    NYHAN DP, PRIBBLE CG, PETERSON WP,NISHIWAKI K, TREMPY GA, DESAI PM, ROCK P, MURRY PA

    Anesthesiology   Vol. 78 ( 6 ) page: 1166-74   1993

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  167. Nω-nitro-L-arginine and pulmonary vascular pressure-flow relationship in conscious dogs. Reviewed

    NISHIWAKI K, NYHAN DP, ROCK P, DESAI PM, PATERSON WP, PRIBBLE CG, MURRAY PA

    Am J Physiol   Vol. 262   page: H1331-7   1992

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  168. Determination of the optimal pressure support level evaluated by measuring transdiaphragmatic pressure. Reviewed

    KIMURA T, TAKEZAWA J, NISHIWAKI K, SHIMADA Y

    Respiratory Diseases Digest   Vol. 4   page: 27-28   1992

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  169. Determination of the optimal pressre support level evaluated by measuring transdiaphragmatic pressure. Reviewed

    KIMURA T, TAKEZAWA J, NISHIWAKI K, SHIMADA YKIMURA T, TAKEZAWA J, NISHIWAKI K, SHIMADA Y

    Chest   Vol. 100   page: 112-7   1991

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  170. Comparison of inspiratory work of breathing in T-piece breathig, PSV, and pleural pressure support ventilation (PPSV). Reviewed

    TAKAHASHI T, TAKEZAWA J, KIMURA T, NISHIWAKI K, SHIMADA Y

    Chest   Vol. 100   page: 1030-4   1991

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  171. Severe tracheal compression caused by false aneurysm arising from the ascending aorta: successful airway management using induced hypotension and bronchoscopy. Reviewed

    NISHIWAKI K, KOMATSU T, SHIMADA Y,NISHIWAKI K, KOMATSU T, SHIMADA Y, TAKEUCHI E, ABE T

    Anesthesiology   Vol. 73   page: 1047-49   1990

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  172. Rise in pulmonary arterial pressure following release of aortic crossclamp in abdominal aortic aneurysmectomy. Reviewed

    KAINUMA M, NISHIWAKI K, SHIMADA Y

    Anesthesiology   Vol. 69   page: 257-60   1988

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Books 6

  1. 標準麻酔科学

    稲田 英一, 森崎 浩, 西脇 公俊, 古家 仁( Role: Edit)

    医学書院  2018  ( ISBN:9784260030304

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    Language:Japanese Book type:Scholarly book

    CiNii Books

  2. 必ず上手くなる!中心静脈穿刺中心静脈カテーテル挿入法(総論)3準備・器材・挿入

    佐藤栄一、西脇公俊、島田康弘( Role: Joint author)

    羊土社  2007 

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    Language:Japanese

  3. 必ず上手くなる! 中心静脈穿刺 リスク・マネージメント上の問題点

    ( Role: Joint author)

    羊土社  2007 

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    Language:Japanese

  4. LISA・中心静脈穿刺(総論)穿刺・挿入操作、挿入後の処置

    西脇公俊、佐藤栄一( Role: Joint author)

    2006 

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    Language:Japanese

  5. SIRSの病態と治療Ⅰ ALI/ARDS

    ( Role: Joint author)

    医薬ジャーナル社  2004 

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    Language:Japanese

    特殊なALI/ARDSの1病態である神経原性肺水腫について、臨床像、肺水腫発生のメカニズム、肺水腫治療・予防について、現在の最先端の情報を概説した。特に神経原性肺水腫発生のメカニズムについて、肺毛細管内圧の上昇によるという従来の説と、我々の報告しているニュウロペプタイドYによる神経性透過性亢進の関与について、日本語でわかり易く説明した。

  6. ARDSのすべて

    ( Role: Joint author)

    医歯薬出版社  2004 

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    Language:Japanese

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Presentations 7

  1. 「手術室の安全管理」によせて

    西脇 公俊

    THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA 

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    Event date: 2013

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  2. 術中MRIを使用した麻酔経験

    中澤 朋子 橋本篤 富田彰 角渕浩央 西脇公俊 島田康弘

    日本麻酔科学会第54回学術集会 

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    Event date: 2007.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  3. 内皮細胞の増殖とVEGFによる血管新生での静脈麻酔剤の影響

    南 勇善 鈴木章悟 西脇公俊 島田康弘

    日本麻酔科学会第54回学術集会 

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    Event date: 2007.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  4. 胸部大血管手術における血小板アフェレーシスの有用性について

    日本麻酔科学会第54回学術集会 

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    Event date: 2007.6

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  5. ヒューマン動脈内皮細胞の単層透過性に対するイソフルランの影響

    鈴木 章悟 南勇善 西脇公俊 島田康弘

    日本麻酔科学会第54回学術集会 

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    Event date: 2007.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  6. 腹部大動脈瘤手術患者におけるカルペリチド低用量持続投与の腎保護効果

    浅野 市子 西脇公俊 梅田亜希子 辻里花 金碧年 島田康弘

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    Event date: 2007.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  7. 大動脈瘤に対するバルーン閉塞併用によるステントグラフト内挿術の麻酔管理

    木村 智政, 佐藤 祐子, 菅原 昭憲, 佐藤 栄一, 西脇 公俊, 島田 康弘

    THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA 

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    Event date: 2002.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

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KAKENHI (Grants-in-Aid for Scientific Research) 5

  1. 脳死関連肺障害の病態解明と予防・治療法の開発ー特にNPYとVEGFと関連して

    Grant number:19K09325  2019.4 - 2022.3

    科学研究費補助金 

    西脇 公俊

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    我々はこれまでに、神経原生肺水腫の発生において、肺交感神経終末でカテコールアミンと共存する神経ペプチドY (NPY)を介した神経性調節による細胞透過性亢進が関与していること、および肺周辺領域における血管内皮細胞増殖因子(VEGF)の発現が肺血管透過性亢進に深く関与していることを明らかにしてきた。本研究では、ヒト正常肺微小血管内皮細胞とヒト気管支上皮細胞株を用いたin vitro細胞透過性アッセイ系やラット脳死モデルを利用したin vivo実験から、脳死関連肺障害病態におけるNPYおよびVEGFの役割を明らかとし、脳死患者の肺障害の予防・治療法を探ることを目的とする。
    研究代表者は、ラット神経付き肺潅流標本およびラットフィブリン誘発神経原性肺水腫モデルを用いた検討において、肺交感神経終末でカテコールアミンと共存する神経ペプチドY(NPY)による神経性調節が細胞透過性に関与することを明らかにした。しかしながら、NPYの作用機序については未だ不明なままである。本研究の目的は、in vitro肺細胞透過性評価系を確立し、NPYの作用機序を細胞レベルで明らかにすることである。
    研究代表者はこれまでに、ヒト正常肺微小血管内皮細胞(HMVEC-L)とヒト気管支上皮細胞株(Calu-3)を用いた、2つのin vitro細胞透過性亢進作用アッセイ系を確立し、NPYの作用を検討してきた。両方のアッセイ系において、1 × 10-7 MのNPYは細胞透過性に影響を及ぼさなかった。しかしながら、ヒト単球細胞株THP-1細胞を分化処理したマクロファージモデル細胞に1 × 10-8 MのNPYを添加し、6時間培養した後の培養上清は、Calu-3アッセイ系で有意な細胞透過性亢進作用を示した。本年度は、Calu-3とTHP-1由来マクロファージモデル細胞を共培養するアッセイ系の構築を試みた。さらに、細胞透過性亢進作用に寄与するタイトジャンクション蛋白の検出に用いる抗体選定を行った。
    Calu-3細胞単層上に、細胞数がCalu-3の約1/3になるようにマクロファージ様細胞を播種する系を作製した。しかしながら、選定したタイトジャンクション蛋白のOccludinやZo-1の抗体を用いた細胞溶解物のウェスタンブロッティングにおいて、Calu-3とマクロファージ様細胞の両方に蛋白発現が見られること(発現量はCalu-3>マクロファージ様細胞)、共培養サンプルで検出される蛋白発現量にバラツキが見られることが判明した。このことから、本共培養系を用いて各種解析を行うことを断念した。
    研究代表者が新たに構築したCalu-3とTHP-1由来マクロファージモデル細胞を共培養するアッセイ系が、NPYの生化学的なメカニズム解析に不適であると判断したことから、細胞透過性亢進作用の評価にも用いることができなくなった。そのため、より実際の肺環境に近いin vitroアッセイ系の構築がスタートに戻る状況となり、進捗はやや遅れている。
    上記に加え、当初の優先検討課題であった「脳死モデルでの神経原生肺水腫に関わるneuropeptidesの同定とVEGFの関与」についても検討を進めているが、マウス脳死モデル作製方法、肺水腫評価法、および肺水腫液と血清中の蛋白質比測定法など、全てが検討途中段階にある。
    肺上皮細胞、マクロファージ細胞、肺微小血管内皮細胞の3つの細胞を共培養系するin vivo肺モデル作製のための検討を引き続き行う。共培養系とは別に、NPY添加したマクロファージモデル細胞の培養上清をCalu-3アッセイ系に添加することで細胞透過性亢進作用が観察されることはすでに確認できている。しかしながら、マクロファージ様細胞に関しては、使用する培地、細胞播種密度、細胞培養期間など、検討必要事項が複数残っている。これらの検討項目を解決した上で、NPYの細胞透過性亢進作用の再評価ならびにNPYのメカニズム解析を行う。
    また、in vivoの検討課題「脳死モデルでの神経原生肺水腫に関わるneuropeptidesの同定とVEGFの関与」では、マウス脳死モデルの早期の確立を目指す。具体的には、マウス頭蓋内に血栓除去用カテーテルを挿入し、バルーンを用いて頭蓋内圧を上昇させ、脳幹部にヘルニアを起こすことにより脳死モデルを作製する。血液ガス分析による肺障害の重症度解析、摘出肺のWet/Dry Ratioの測定、血中、気管支肺胞洗浄液中および肺組織中の神経ペプチド同定を可能にし、神経原生肺水腫を抑制できる薬物の評価系を作製する。

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  2. Elucidation of the pathophysiology of brain death-related lung injury and development of precaution and remedy -especially in relation to NPY and VEGF

    Grant number:15K10510  2015.4 - 2019.3

    NISHIWAKI Kimitoshi

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    The aim of the present study was to clarify the action mechanism of neuropeptide Y (NPY), which was considered to be related to the cell permeability in neurogenic pulmonary edema (NPE), using two in vitro cell permeability evaluation systems of human normal lung microvascular endothelial cells (HMVEC-L) and human bronchial epithelial cell lines Calu-3.
    NPY at the concentration of 1.0E-7 M did not affect cell permeability in both systems. However, the addition of macrophage medium treated with 1.0E-8 M NPY significantly increased the Calu-3 cell permeability. These results suggest that NPY did not act directly on both endothelial and epithelial cells, but could cause the increase in the lung epithelial cell permeability via macrophage stimulation in NPE pathophysiology.

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  3. Clarification of the pathophysiology of brain death-associated lung function impairment and research on the precaution and remedy

    Grant number:23592251  2011 - 2013

    NISHIWAKI KIMITOSHI

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\5070000 ( Direct Cost: \3900000 、 Indirect Cost:\1170000 )

    It has been suggested as a reason for the difficulty in the lung transplantation from a brain-dead donor that brain edema and increased intracranial pressure induce neurogenic pulmonary edema (NPE) resulting in the lung function impairment. In the present study, we established an in vitro human pulmonary endothelial cell model and assessed the effect of neuropeptide Y (NPY), which was discovered as a causative agent in NPE, on cell permeability. NPY alone showed no statistically significant enhancement of cell permeability in the range from 1 x 10-11 to 1 x 10-7 M. In addition, neither hypoxic (5% O2) condition nor combination with norepinephrine caused NPY-induced cell permeability. These results suggest that the site of action of NPY is not in pulmonary endothelial cells in NPE.

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  4. The mechanism of the increase of pulmonary endothelial cell permeability induced by the increased sympathetic tone and development of the new therapy for ARDS.

    Grant number:20591801  2008 - 2010

    NISHIWAKI Kimitoshi

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    We investigated the mechanism of the increase of pulmonary endothelial cell permeability induced by the NPY, using transendothelial FITC-labeled albumin permeability assay.
    The incubation culture plates were comprised of 2 chambers, the upper chamber utilized a porous membrane and the lower used a 24-well micro plate. HPAEC (Human Pulmonary Artery Endothelial Cells) were seeded in the intercell for 2W. The permeability of the endothelial cell monolayer was assessed by measuring the concentration of FITC-labeled albumin from the upper to the lower chamber for 60minutes. The permeability at each NPY conditions were expressed as % compared to the control condition (no NPY) at 100%. The permeability at NPY 0, 10^<-7>, 10^<-6>, 10^<-5>, 10^<-4>, 10^<-3>, 10^<-2>, 10^<-1>, 1, 10μg/ml were 100, 101, 102, 169, 173, 163, 172, 220, 229, 226% respectively. These results showed that NPY increased the permeability of the HPAEC monolayer in dose-dependent manner.

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  5. 神経原性肺水腫におけるneuropeptideYの透過性亢進作用機序の解明

    Grant number:16591532  2004.4 - 2007.3

    科学研究費補助金  基盤研究(C)

    西脇 公俊

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    Authorship:Principal investigator  Grant type:Competitive

 

Teaching Experience (On-campus) 9

  1. 痛み治療の進歩

    2020

  2. 麻酔学

    2012

  3. 痛み治療の進歩 痛みの臨床ー神経障害性疼痛を理解する

    2012

  4. 痛み治療の進歩 痛みの特殊治療

    2012

  5. 周術期全身管理の最前線 麻酔と長期予後

    2012

  6. 麻酔学

    2011

  7. 痛み治療の進歩 痛みの臨床ー神経障害性疼痛を理解する

    2011

  8. 痛み治療の進歩 痛みの特殊治療

    2011

  9. 周術期全身管理の最前線 麻酔と長期予後

    2011

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Teaching Experience (Off-campus) 3

  1. 麻酔科学 呼吸管理

    2020.6 Aichi Medical University)

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    Level:Undergraduate (specialized)  Country:Japan

  2. 麻酔科学 呼吸管理

    2020.6 Aichi Medical University)

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    Level:Undergraduate (specialized)  Country:Japan

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  3. 痛み治療の進歩

    2020 Nagoya University)

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    Level:Undergraduate (liberal arts)  Country:Japan

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Social Contribution 1

  1. 医療安全全国共同行動の支援チーム活動

    2012.1

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    医療安全を推進するためのボランティア活動