研究者詳細 - 井原　邦夫

論文 - 井原　邦夫

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The mechanosensitive channel YbdG from Escherichia coli has a role in adaptation to osmotic up-shock. 査読有り

Amemiya S, Toyoda H, Kimura M, Saito H, Kobayashi H, Ihara K, Kamagata K, Kawabata R, Kato S, Nakashimada Y, Furuta T, Hamamoto S, Uozumi N

The Journal of biological chemistry 2019年6月

Cholecystokinin induces crowing in chickens 査読有り国際誌 Open Access

Shimmura, T; Tamura, M; Ohashi, S; Sasaki, A; TakamichiYamanaka; Nakao, N; Ihara, K; Okamura, S; TakashiYoshimura

SCIENTIFIC REPORTS 9 巻 ( 1 ) 頁： 3978 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Scientific Reports

Animals that communicate using sound are found throughout the animal kingdom. Interestingly, in contrast to human vocal learning, most animals can produce species-specific patterns of vocalization without learning them from their parents. This phenomenon is called innate vocalization. The underlying molecular basis of both vocal learning in humans and innate vocalization in animals remains unknown. The crowing of a rooster is also innately controlled, and the upstream center is thought to be localized in the nucleus intercollicularis (ICo) of the midbrain. Here, we show that the cholecystokinin B receptor (CCKBR) is a regulatory gene involved in inducing crowing in roosters. Crowing is known to be a testosterone (T)-dependent behavior, and it follows that roosters crow but not hens. Similarly, T-administration induces chicks to crow. By using RNA-sequencing to compare gene expression in the ICo between the two comparison groups that either crow or do not crow, we found that CCKBR expression was upregulated in T-containing groups. The expression of CCKBR and its ligand, cholecystokinin (CCK), a neurotransmitter, was observed in the ICo. We also showed that crowing was induced by intracerebroventricular administration of an agonist specific for CCKBR. Our findings therefore suggest that the CCK system induces innate vocalization in roosters.

DOI： 10.1038/s41598-019-40746-9

Comprehensive investigation of the gene expression system regulated by an Aspergillus oryzae transcription factor XlnR using integrated mining of gSELEX-Seq and microarray data. 査読有り

Oka H, Kojima T, Ihara K, Kobayashi T, Nakano H

BMC genomics 20 巻 ( 1 ) 頁： 16 2019年1月

Obesity and mental health improvement following nutritional education focusing on gut microbiota composition in Japanese women: a randomised controlled trial. 査読有り

Uemura M, Hayashi F, Ishioka K, Ihara K, Yasuda K, Okazaki K, Omata J, Suzutani T, Hirakawa Y, Chiang C, Aoyama A, Ohira T

European journal of nutrition 2018年12月

Three-Step Isomerization of the Retinal Chromophore during the Anion Pumping Cycle of Halorhodopsin. 査読有り国際誌

Kouyama T, Ihara K, Maki K, Chan SK

Biochemistry 57 巻 ( 41 ) 頁： 6013 - 6026 2018年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Biochemistry

The anion pumping cycle of halorhodopsin from Natronomonas pharaonis (pHR) is initiated when the all-trans/15-anti isomer of retinal is photoisomerized into the 13-cis/15-anti configuration. A recent crystallographic study suggested that a reaction state with 13-cis/15-syn retinal occurred during the anion release process, i.e., after the N state with the 13-cis/15-anti retinal and before the O state with all-trans/15-anti retinal. In this study, we investigated the retinal isomeric composition in a long-living reaction state at various bromide ion concentrations. It was found that the 13-cis isomer (csHR′), in which the absorption spectrum was blue-shifted by ∼8 nm compared with that of the trans isomer (taHR), accumulated significantly when a cold suspension of pHR-rich claret membranes in 4 M NaBr was illuminated with continuous light. Analysis of flash-induced absorption changes suggested that the branching of the trans photocycle into the 13-cis isomer (csHR′) occurs during the decay of an O-like state (O′) with 13-cis/15-syn retinal; i.e., O′ can decay to either csHR′ or O with all-trans/15-anti retinal. The efficiency of the branching reaction was found to be dependent on the bromide ion concentration. At a very high bromide ion concentration, the anion pumping cycle is described by the scheme taHR -(hν) → K → L1a ↔L1b ↔N ↔N′ ↔O′ ↔csHR′ ↔taHR. At a low bromide ion concentration, on the other hand, O′ decays into taHR via O.

DOI： 10.1021/acs.biochem.8b00631

Draft Genome Sequence of Burkholderia vietnamiensis Strain RS1, a Nitrogen-Fixing Endophyte Isolated from Sweet Potato. 査読有り国際誌 Open Access

Shinjo R, Uesaka K, Ihara K, Sakazaki S, Yano K, Kondo M, Tanaka A

Microbiology resource announcements 7 巻 ( 3 ) 2018年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Microbiology Resource Announcements

Burkholderia vietnamiensis strain RS1 is an endophytic bacterium with nitrogen-fixing ability that was isolated from tuberous roots of sweet potato. Here, we present its draft genome of 6,542,727 bases that contains a cluster of genes associated with nitrogen fixation. This genome sequence will provide important insights into the plant growth-promoting potential of endophytic bacteria.

DOI： 10.1128/MRA.00820-18

In vivo transposon tagging in the nonheterocystous nitrogen-fixing cyanobacterium Leptolyngbya boryana

Tomatsu Chie, Uesaka Kazuma, Yamakawa Hisanori, Tsuchiya Tohru, Ihara Kunio, Fujita Yuichi

FEBS LETTERS 592 巻 ( 10 ) 頁： 1634-1642 2018年5月

Co-expression of the calcitonin receptor gene in the hypothalamic kisspeptin neurons in female rats 査読有り

Assadullah, Nahoko Ieda, Narumi Kawai, Hirotaka Ishii, Kunio Ihara, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura

Reprod. Med. Biol. 2018年

SLO potassium channels antagonize premature decision making in C. elegans. 査読有り

Aoki I, Tateyama M, Shimomura T, Ihara K, Kubo Y, Nakano S, Mori I

Communications biology 1 巻頁： 123 2018年

Fulminant type 1 diabetes mellitus in Japanese children and adolescents: Multi-institutional joint research of the Japanese study group of insulin therapy for childhood and adolescent diabetes

Shiga K., Urakami T., Suzuki J., Igarashi Y., Tajima H., Amemiya S., Sugihara S., Takahashi I., Tanahashi Y., Matsuo K., Iwamoto J., Yatsuga S., Endo A., Takemoto K., Hamada J., Ihara K., Ohki Y., Takaya R., Mochizuki T., Kawamura T., Horita Y., Furujo M., Inoue M., Hasegawa K., Adachi M., Okajima M., Shimura K., Ohtsu S., Kitsuda K., Ito Y., Hori T., Ishii K., Kawada Y., Nakajima H., Ito I., Nakamura K., Miyagawa S., Jinno K., Horikawa R., Yoshida T., Fukami M., Mori T., Kobayashi K., Konda S., Sasaki N., Kikuchi T., Musha I., Aizu K., Mochizuki H., Hotsubo T., Sato K., Yamamoto Y., Kadowaki H., Nishii A., Matsui K., Yokota I., Miyoshi T., Takubo N., Hara Y., Matsuura N., Miyamoto S., Soneda S., Takahashi T., Tsubouchi K., Tatematsu T., Minamitani K., Ogawa E., Izumi Y., Sasaki G., Tachikawa E., Uchigata Y., Yasuda Y., Sasaki K., Kitanaka S., Isojima T., Fujiwara I., Kanno J., Kotani Y., Ayabe T., Shimura N., Ichikawa J., Hanaki K., Nagaishi J., Kanzaki S., Fujimoto M., Ito J., Mizuno H., Abe Y., Nagasaki K., Ogawa Y., Kadotani S., Kashihara Y., Okuno M., Ogata T., Ohtaka K., Miyako K., Kohno H., Fujisawa T., Suga S., Koike A.

Endocrine Journal 65 巻 ( 8 ) 頁： 795 - 803 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Endocrine Journal

Fulminant type 1 diabetes mellitus (FT1DM) is a subtype of type 1 diabetes mellitus characterized by a remarkably abrupt onset. In Japan, FT1DM accounts for approximately 20% of acute-onset adult type 1 diabetes mellitus cases; however, reports of pediatric-onset FT1DM are rare. We aimed to determine the frequency and clinical characteristics of FT1DM in Japanese children and adolescents by conducting a 2-phase questionnaire survey among the members of the Japanese Study Group of Insulin Therapy for Childhood and Adolescent Diabetes (JSGIT) regarding their clinical experience with FT1DM. Responses were obtained from 54 of the 79 participating hospitals (68.4%). Of these, 8 hospitals managed a total of 15 pediatric patients with FT1DM (4 patients in each of 2 hospitals, 2 patients in 1 hospital, and 1 patient in each of 5 hospitals). The distribution of patient age was biphasic, with peaks in children younger than 5 years and older than 8 years of age. The clinical characteristics of FT1DM in this population (such as the duration from onset of symptoms to diagnosis, severity of symptoms, preceding flu-like episodes, and abnormal laboratory data) did not differ from those of patients with adult-onset FT1DM. The frequency of pediatric-onset FT1DM is low compared with that of adult-onset FT1DM. The genetic background and susceptibility patterns of pediatric patients with FT1DM may differ from those typical of adults with FT1DM, but both age groups share similar clinical characteristics.

DOI： 10.1507/endocrj.EJ17-0029

Scopus

Incidence rate and characteristics of symptomatic vitamin d deficiency in children: A nationwide survey in Japan Open Access

Kubota T., Nakayama H., Kitaoka T., Nakamura Y., Fukumoto S., Fujiwara I., Hasegawa Y., Ihara K., Kitanaka S., Koyama S., Kusuda S., Mizuno H., Nagasaki K., Oba K., Sakamoto Y., Takubo N., Shimizu T., Tanahashi Y., Hasegawa K., Tsukahara H., Yorifuji T., Michigami T., Ozono K.

Endocrine Journal 65 巻 ( 6 ) 頁： 593 - 599 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Endocrine Journal

There is concern that vitamin D deficiency is prevalent among children in Japan as well as worldwide. We conducted a nationwide epidemiologic survey of symptomatic vitamin D deficiency to observe its incidence rate among Japanese children. A questionnaire inquiring the number of new patients with vitamin D deficiency rickets and/or hypocalcemia for 3 years was sent to 855 randomly selected hospitals with a pediatrics department in Japan. In this survey, we found that 250 children were diagnosed with symptomatic vitamin D deficiency. The estimated number of patients with symptomatic vitamin D deficiency per year was 183 (95% confidence interval (CI): 145–222). The overall annual incidence rate among children under 15 years of age was 1.1 per 100,000 population (95% CI: 0.9–1.4). The second survey has provided detailed information on 89 patients with symptomatic vitamin D deficiency under 5 years of age in hospitals in the current research group. The nationwide and second surveys estimated the overall annual incidence rate of symptomatic vitamin D deficiency in children under 5 years of age to be 3.5 (2.7–4.2) per 100,000 population. The second survey revealed 83% had bowed legs, 88% had exclusive breastfeeding, 49% had a restricted and/or unbalanced diet and 31% had insufficient sun exposure among the 89 patients. This is the first nationwide survey on definitive clinical vitamin D deficiency in children in Japan. Elucidating the frequency and characteristics of symptomatic vitamin D deficiency among children is useful to develop preventative public health strategies.

DOI： 10.1507/endocrj.EJ18-0008

Open Access

Scopus

Salinarchaeum chitinilyticum sp nov., a chitin-degrading haloarchaeon isolated from commercial salt

Minegishi Hiroaki, Enomoto Shigeaki, Echigo Akinobu, Shimane Yasuhiro, Kondo Yusuke, Inoma Ayumi, Kamekura Masahiro, Takai Ken, Itoh Takashi, Ohkuma Moriya, Ihara Kunio, Takahashi-Ando Naoko, Fukushima Yasumasa, Ishii Shigeru, Yoshida Yasuhiko, Usami Ron

INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY 67 巻 ( 7 ) 頁： 2274-2278 2017年7月

Complete Chloroplast Genome Sequence of the Early Diverging Green Alga Palmophyllum crassum.

Furukawa R, Kunugi M, Ihara K, Takabayashi A, Tanaka A

Genome announcements 5 巻 ( 10 ) 2017年3月

Transcriptional regulation of CmpR, the LysR family protein involved in CO2-responsive gene regulation in the cyanobacterium Synechococcus elongatus 査読有り

Lu-Lu Pan1, Kiyoshi Onai2, Kazuma Uesaka1, Kunio Ihara2, Takumi Natsume1, Nobuyuki Takatani1, Masahiro Ishiura2 and Tatsuo Omata1*

Biomedical Genetics and Genomics 1 巻 ( 5 ) 頁： 1-6 2017年1月

Identification of a novel protein kinase that affects the chronological lifespan in fission yeast

Kurauchi Tatsuhiro, Hashizume Aya, Imai Yuki, Hayashi Kanako, Tsubouchi Satoshi, Ihara Kunio, Ohtsuka Hokuto, Aiba Hirofumi

FEMS MICROBIOLOGY LETTERS 364 巻 ( 2 ) 2017年1月

Exome-wide association study identifies clec3b missense variant p.s106g as being associated with extreme longevity in east asian populations 査読有り

Tanisawa K.

Journals of Gerontology - Series A Biological Sciences and Medical Sciences 72 巻 ( 3 ) 頁： 309-318 2017年

Photochemical characterization of actinorhodopsin and its functional existence in the natural host. 査読有り

Nakamura S, Kikukawa T, Tamogami J, Kamiya M, Aizawa T, Hahn MW, Ihara K, Kamo N, Demura M.

Biochim Biophys Acta. 1857 巻 ( 12 ) 頁： 1900-1908 2016年12月

A simple method for isolation and construction of markerless cyanobacterial mutants defective in acyl-acyl carrier protein synthetase. 査読有り

Kojima K, Keta S, Uesaka K, Kato A, Takatani N, Ihara K, Omata T, Aichi M.

Appl Microbiol Biotechnol. 100 巻 ( 23 ) 頁： 10107-10113 2016年12月

Haloparvum alkalitolerans sp. nov., alkali-tolerant haloarchaeon isolated from commercial salt. 査読有り

Kondo Y, Minegishi H, Echigo A, Shimane Y, Kamekura M, Itoh T, Ohkuma M, Tanaka A, Takahashi-Ando N, Fukushima Y, Yoshida Y, Ihara K, Usami R.

Int J Syst Evol Microbiol. 66 巻 ( 12 ) 頁： 5314-5319 2016年12月

Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies. 査読有り

Hirano Y, Ihara K, Masuda T, Yamamoto T, Iwata I, Takahashi A, Awata H, Nakamura N, Takakura M, Suzuki Y, Horiuchi J, Okuno H, Saitoe M.

Nat Commun. 7 巻頁： 13471 2016年11月

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