Faculty Profiles - MIZOGUCHI, Hiroyuki

Papers - MIZOGUCHI, Hiroyuki

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Monochloramine impairs mucosal blood flow response and healing of gastric lesions in rats: relation to capsaicin-sensitive sensory neurons Reviewed

Takeuchi K, Suzuki K, Mizoguchi H, Araki H, and Nishiwaki H

Journal of Gastroenterology and Hepatology Vol. 16 ( 3 ) page： 282-289 2001.3

Lack of small intestinal toxicity of nitric oxide-releasing indomethacin, NCX-530, in rats Reviewed

Mizoguchi H, Hase S, Tanaka A, and Takeuchi K

Alimentary Pharmacology & Therapeutics Vol. 15 ( 2 ) page： 257-267 2001.2

Gastrointestinal sparing anti-inflammatory drugs-effects on ulcerogenic and healing responses Reviewed

Takeuchi K, Tanaka A, Suzuki K, and Mizoguchi H

Current Pharmaceutical Design Vol. 7 ( 1 ) page： 49-69 2001.1

一酸化窒素遊離型インドメタシンの小腸傷害性についての検討

溝口博之, 田中晶子, 竹内孝治

Ulcer Research Vol. 28 page： 157-160 2001

Prostaglandin E inhibits indomethacin-induced gastric lesions through EP1 receptors. Reviewed

Suzuki K, Araki H, Mizoguchi H, Furukawa O, and Takeuchi K

Digestion Vol. 63 ( 2 ) page： 92-101 2001

The roles of nitric oxide and prostaglandins in alterations of ulcerogenic and healing responses in adjuvant-induced arthritic rat stomachs Reviewed

Kato S, Tanaka A, Kunikata T, Mizoguchi H, and Takeuchi K.

Alimentary Pharmacology & Therapeutics Vol. 14 ( s1 ) page： 18-25 2000.4

Regulatory mechanism of acid secretion in the damaged stomach: role of endogenous nitric oxide Reviewed

Takeuchi K, Araki H, Kawauchi S, Kunikata T, Mizoguchi H, and Tashima K.

Journal of Gastroenterology and Hepatology Vol. 15 ( s1 ) page： 37-45 2000.3

インドメタシン誘起小腸傷害の発生における一酸化窒素の二面作用 Invited

田中晶子, 溝口博之, 加藤伸一, 竹内孝治

Ulcer Research Vol. 27 page： 176-179 2000

プロスタグランジンEによるインドメタシン誘起胃損傷の抑制: EP受容体サブタイプとの関連 Invited

鈴木敬三, 荒木秀夫, 溝口博之, 竹内孝治

Cytoprotection & biology Vol. 8 page： 31-34 2000

一酸化窒素遊離型インドメタシンの小腸傷害性について Invited

田中晶子, 溝口博之, 鈴木敬三, 加藤伸一, 竹内孝冶

Cytoprotection & biology Vol. 8 page： 27-30 2000

Protective effect of Irsogladine on monochloramine-induced gastric mucosal lesions in rats: a comparative study with rebamipide Reviewed

Yamamoto H, Umeda M, Mizoguchi H, Kato S, Takeuchi K.

World J. Gastroenterol. Vol. 5 ( 6 ) page： 477-482 1999.12

Language：English Publishing type：Research paper (scientific journal)

AIM:To examine the effect of irsogladine, a novel antiulcer drug, on the mucosal ulcerogenic response to monochloramine (NH(2)Cl) in rat stomach, in comparison with rebamipide, another antiulcer drug with cytoprotective a ctivity.METHODS AND RESULTS:Oral administration of NH(2)Cl-(120mM) produced severe hemorrhagic lesions in unanesthetized rat stomachs.Both irsogladine (1mg/kg-10mg/ kg,po) and rebamipide (30mg/kg-100mg/kg, po) dose dependently prevented the development of these lesions in response to NH(2)Cl, the effect of irsogladine was significant at 3mg/kg or greater, and that of rebamipide only at 100mg/kg. The protective effect of irsogladine on NH(2)Cl induced gastric lesions was significantly reduced by N( G) nitro L arginine methyl ester (L-NAME) but not by indomethacin, while that of rebamipide was significantly mitigated by indomethacin but not by L-NAME. Topical application of NH(2)Cl-(20mM)caused a marked reduction of potential difference (PD) in exvivo stomachs. This PD reduction was not affected by mucosal application of irso-gladine, but significantly prevented by rebamipide. The mucosal exposure to NH(4)OH (120mM) also caused a marked PD reduction in the ischemic stomach (bleeding from the carotid artery), resulting in gastric lesions. These ulcerogenic and PD responses caused by NH(4)OH plus ischemia were also significantly mitigated by rebamipide, in an indomethacin sensitive manner, while irsogladine potently prevented such lesions without affecting the PD response, in a L-NAME sensitive manner.CONCLUSION:These results suggest that (1)NH(2)Cl gen-erated either exogenously or endogenously damages the gastric mucosa, (2)both irsogladine and rebamipide protect the stomach against injury caused by NH(2)Cl,and (3)the mechanism underlying the protective action of irsogladine is partly mediated by endogenous nitric oxide, while that of rebamipide is in part mediated by endogenous prostaglandins.

Roles of endogenous prostaglandins and nitric oxide in gastroduodenal ulcerogenic responses induced in rats by hypothermic stress Reviewed

Takeuchi K, Suzuki K, Araki H, Mizoguchi H, Sugamoto S, and Umdeda M.

Journal of Physiology-Paris Vol. 93 ( 5 ) page： 423-431 1999.11

Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats Reviewed

Tanaka A, Kunikata T, Mizoguchi H, Kato S, and Takeuchi K.

Journal of Physiology and Pharmacology Vol. 50 ( 3 ) page： 405-417 1999.9

Cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs and gastric mucosal responses Reviewed

Takeuchi K, Suzuki K, Yamamoto H, Araki H, Mizoguchi H, and Ukawa H.

Journal of Physiology and Pharmacology Vol. 49 ( 4 ) page： 501-513 1998.12

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