研究者詳細 - 杉山　伸

論文 - 杉山　伸

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*Involvement of the mitochondrial protein translocator component tim50 in growth, cell proliferation and the modulation of respiration in Drosophila. 査読有り

Sugiyama S, Moritoh S, Furukawa Y, Mizuno T, Lim YM, Tsuda L, Nishida Y.

Genetics 176 巻 ( 2 ) 頁： 927-936 2007年6月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Allelic mutants exhibiting growth defects in Drosophila were isolated. Molecular cloning identified the responsible gene as a budding yeast Tim50 ortholog, and thus it was named tiny tim 50 (ttm50). The weak allele (ttm50(Gp99)) produced small flies due to reduced cell size and number, and growth terminated at the larval stage in the strong alleles (ttm50(IE1) and ttm50(IE2)). Twin-spot analysis showed fewer cells in ttm50(Gp99) clones, whereas ttm50(IE1) clones did not proliferate, suggesting that the gene has an essential cellular function. Tim50 is known to maintain mitochondrial membrane potential (MMP) while facilitating inner-membrane protein transport. We found that tagged Ttm50 also localized to mitochondria and that mitochondrial morphology and MMP were affected in mutants, indicating that mitochondrial dysfunction causes the developmental phenotype. Conversely, ttm50 overexpression increased MMP and apoptosis. Co-expression of p35 suppressed this apoptosis, resulting in cell overproliferation. Interestingly, ttm50 transcription was tissue specific, corresponding to elevated MMP in the larval midgut, which was decreased in the mutant. The correlation of ttm50 expression levels with differences in MMP match its proposed role in mitochondrial permeability barrier maintenance. Thus a mitochondrial protein translocase component can play active roles in regulating metabolic levels, possibly for modulation of physiological function or growth in development.

Non-farnesylated B-type lamin can tether chromatin inside the nucleus and its chromatin interaction requires the Ig-fold region 査読有り

Uchino Ryo, Sugiyama Shin, Katagiri Motoi, Chuman Yoshiro, Furukawa Kazuhiro

CHROMOSOMA 126 巻 ( 1 ) 頁： 125 - 144 2017年2月

Loss of Drosophila A-type lamin C initially causes tendon abnormality including disintegration of cytoskeleton and nuclear lamina in muscular defects 査読有り

Ryo Uchino, Yu-ki Nonaka, Tuneyoshi Horigome, Shin Sugiyama, and Kazuhiro Furukawa

Developmental Biology 373 巻 ( 1 ) 頁： 216-27 2013年1月

Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila 査読有り

Ziguang Liu, Shinya Matsuoka, Ami Enoki, Tsuyoshi Yamamoto, Kazuhiro Furukawa, Yasutoyo Yamasaki, Yasuyoshi Nishida, and Shin Sugiyama

Development, Growth & Differentiation 53 巻 ( 6 ) 頁： 822-841 2011年

*A-type and B-type lamins initiate layer assembly at distinct areas of the nuclear envelope in living cells. 査読有り

Furukawa K, Ishida K, Tsunoyama TA, Toda S, Osoda S, Horigome T, Fisher PA, Sugiyama S.

Experimental Cell Research 315 巻 ( 7 ) 2009年

*BAF as a caspase-dependent mediator of nuclear apoptosis in Drosophila 査読有り

Furukawa K, Aida T, Nonaka Y, Osoda S, Juarez C, Horigome T, Sugiyama S.

Journal of Structural Biology 160 巻 ( 2 ) 頁： 125-134 2007年11月

Essential roles of myosin phosphatase in the maintenance of epithelial cell integrity of Drosophila imaginal disc cells. 査読有り

Mitonaka T, Muramatsu Y, Sugiyama S, Mizuno T, Nishida Y.

Developmental Biology 309 巻 ( 1 ) 頁： 78-86 2007年9月

Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. 査読有り

Osouda S, Nakamura Y, de Saint Phalle B, McConnell M, Horigome T, Sugiyama S, Fisher PA, Furukawa K.

Developmental Biology 284 巻 ( 1 ) 頁： 219-232 2005年8月

Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila. 査読有り

Furukawa K, Sugiyama S, Osouda S, Goto H, Inagaki M, Horigome T, Omata S, McConnell M, Fisher PA, Nishida Y.

Journal of Cell Science 116 巻頁： 3811-3823 2003年

A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment. 査読有り

Oishi I, Sugiyama S, Otani H, Yamamura H, Nishida Y, Minami Y.

Mechanisms of Development 71 巻 ( 1-2 ) 頁： 49-63 1998年2月

Identification of a Novel <u>Drosophila</u> Protein Kinase Highly Homologous to Protein Kinase N(PKN) 査読有り

Ueno N, Oishi I, Sugiyama S, Nishida Y, Minami Y, Yamamura H.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 232 巻 ( 18 ) 頁： 126-127 1997年

A Novel <u>Drosophila</u> Receptor Tyrosine Kinase Expressed Specifically in the Nervous System 査読有り

Oishi I, Sugiyama S, Liu ZJ, Yamamura H, Nishida Y, Minami Y.

The Journal of Biological Chemistry 272 巻 ( 18 ) 頁： 11916-11923 1997年

The Raf/MAP kinase cascade in cell cycle regulation and differentiation in Drosophila. 招待有り

Nishida Y, Inoue YH, Tsuda L, Adachi-Yamada T, Lim YM, Hata M, Ha HY, Sugiyama S.

Cell Structure and Function 21 巻 ( 5 ) 頁： 437-444 1996年10月

体節パターン形成にかかわる遺伝子群

蛋白質核酸酵素 38 巻 ( 15 ) 頁： 2492-2504 1993年

*Cytoplasmic factors determining antevoposterior polarity in the Drosophila embryo 査読有り

Sugiyama, S. and Okada, M.

Development Genes and Evolution 198 巻頁： 402-410 1990年7月

*Analysis of cytoplasmic activity dependent on the Drosophila terminal pattern gene torso 査読有り

Sugiyama S, Okada M.

Developmental Biology 141 巻 ( 2 ) 頁： 299-305 1990年

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