Faculty Profiles - SUGIYAMA, Shin

Papers - SUGIYAMA, Shin

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*Involvement of the mitochondrial protein translocator component tim50 in growth, cell proliferation and the modulation of respiration in Drosophila. Reviewed

Sugiyama S, Moritoh S, Furukawa Y, Mizuno T, Lim YM, Tsuda L, Nishida Y.

Genetics Vol. 176 ( 2 ) page： 927-936 2007.6

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Allelic mutants exhibiting growth defects in Drosophila were isolated. Molecular cloning identified the responsible gene as a budding yeast Tim50 ortholog, and thus it was named tiny tim 50 (ttm50). The weak allele (ttm50(Gp99)) produced small flies due to reduced cell size and number, and growth terminated at the larval stage in the strong alleles (ttm50(IE1) and ttm50(IE2)). Twin-spot analysis showed fewer cells in ttm50(Gp99) clones, whereas ttm50(IE1) clones did not proliferate, suggesting that the gene has an essential cellular function. Tim50 is known to maintain mitochondrial membrane potential (MMP) while facilitating inner-membrane protein transport. We found that tagged Ttm50 also localized to mitochondria and that mitochondrial morphology and MMP were affected in mutants, indicating that mitochondrial dysfunction causes the developmental phenotype. Conversely, ttm50 overexpression increased MMP and apoptosis. Co-expression of p35 suppressed this apoptosis, resulting in cell overproliferation. Interestingly, ttm50 transcription was tissue specific, corresponding to elevated MMP in the larval midgut, which was decreased in the mutant. The correlation of ttm50 expression levels with differences in MMP match its proposed role in mitochondrial permeability barrier maintenance. Thus a mitochondrial protein translocase component can play active roles in regulating metabolic levels, possibly for modulation of physiological function or growth in development.

Non-farnesylated B-type lamin can tether chromatin inside the nucleus and its chromatin interaction requires the Ig-fold region Reviewed

Ryo Uchino, Shin Sugiyama, Motoi Katagiri, Yoshiro Chuman, Kazuhiro Furukawa

Chromasoma Vol. 126 ( 1 ) page： 125 - 144 2017.2

Loss of Drosophila A-type lamin C initially causes tendon abnormality including disintegration of cytoskeleton and nuclear lamina in muscular defects Reviewed

Ryo Uchino, Yu-ki Nonaka, Tuneyoshi Horigome, Shin Sugiyama, and Kazuhiro Furukawa

Developmental Biology Vol. 373 ( 1 ) page： 216-27 2013.1

Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila Reviewed

Ziguang Liu, Shinya Matsuoka, Ami Enoki, Tsuyoshi Yamamoto, Kazuhiro Furukawa, Yasutoyo Yamasaki, Yasuyoshi Nishida, and Shin Sugiyama

Development, Growth & Differentiation Vol. 53 ( 6 ) page： 822-841 2011

*A-type and B-type lamins initiate layer assembly at distinct areas of the nuclear envelope in living cells. Reviewed

Furukawa K, Ishida K, Tsunoyama TA, Toda S, Osoda S, Horigome T, Fisher PA, Sugiyama S.

Experimental Cell Research Vol. 315 ( 7 ) 2009

*BAF as a caspase-dependent mediator of nuclear apoptosis in Drosophila Reviewed

Furukawa K, Aida T, Nonaka Y, Osoda S, Juarez C, Horigome T, Sugiyama S.

Journal of Structural Biology Vol. 160 ( 2 ) page： 125-134 2007.11

Essential roles of myosin phosphatase in the maintenance of epithelial cell integrity of Drosophila imaginal disc cells. Reviewed

Mitonaka T, Muramatsu Y, Sugiyama S, Mizuno T, Nishida Y.

Developmental Biology Vol. 309 ( 1 ) page： 78-86 2007.9

Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. Reviewed

Osouda S, Nakamura Y, de Saint Phalle B, McConnell M, Horigome T, Sugiyama S, Fisher PA, Furukawa K.

Developmental Biology Vol. 284 ( 1 ) page： 219-232 2005.8

Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila. Reviewed

Furukawa K, Sugiyama S, Osouda S, Goto H, Inagaki M, Horigome T, Omata S, McConnell M, Fisher PA, Nishida Y.

Journal of Cell Science Vol. 116 page： 3811-3823 2003

A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment. Reviewed

Oishi I, Sugiyama S, Otani H, Yamamura H, Nishida Y, Minami Y.

Mechanisms of Development Vol. 71 ( 1-2 ) page： 49-63 1998.2

Identification of a Novel <u>Drosophila</u> Protein Kinase Highly Homologous to Protein Kinase N(PKN) Reviewed

Ueno N, Oishi I, Sugiyama S, Nishida Y, Minami Y, Yamamura H.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 232 ( 18 ) page： 126-127 1997

A Novel <u>Drosophila</u> Receptor Tyrosine Kinase Expressed Specifically in the Nervous System Reviewed

Oishi I, Sugiyama S, Liu ZJ, Yamamura H, Nishida Y, Minami Y.

The Journal of Biological Chemistry Vol. 272 ( 18 ) page： 11916-11923 1997

The Raf/MAP kinase cascade in cell cycle regulation and differentiation in Drosophila. Invited

Nishida Y, Inoue YH, Tsuda L, Adachi-Yamada T, Lim YM, Hata M, Ha HY, Sugiyama S.

Cell Structure and Function Vol. 21 ( 5 ) page： 437-444 1996.10

Genes Involved in Segmentation

PROTEIN, NUCLEIC ACID AND ENZYME Vol. 38 ( 15 ) page： 2492-2504 1993

*Cytoplasmic factors determining antevoposterior polarity in the Drosophila embryo Reviewed

Sugiyama, S. and Okada, M.

Development Genes and Evolution Vol. 198 page： 402-410 1990.7

*Analysis of cytoplasmic activity dependent on the Drosophila terminal pattern gene torso Reviewed

Sugiyama S, Okada M.

Developmental Biology Vol. 141 ( 2 ) page： 299-305 1990

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Papers - SUGIYAMA, Shin