Updated on 2022/04/13

写真a

 
SUGIYAMA, Shin
 
Organization
Graduate School of Science Lecturer
Graduate School
Graduate School of Science
Undergraduate School
School of Science Department of Biological Science
Title
Lecturer

Degree 2

  1. Master of Science

  2. Doctor of Science

Research Areas 1

  1. Others / Others  / Developmental biology

Current Research Project and SDGs 1

  1. Analysis of Signal Tranduction genes involved in Morphogenesis in Drosophila

Education 2

  1. University of Tsukuba   Graduate School, Division of Bioresearch

    - 1989

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    Country: Japan

  2. University of Tsukuba   Second Cluster of College

    - 1983

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    Country: Japan

Professional Memberships 2

  1. Genetics Society of America

  2. 日本分子生物学会

 

Papers 16

  1. *Involvement of the mitochondrial protein translocator component tim50 in growth, cell proliferation and the modulation of respiration in Drosophila. Reviewed

    Sugiyama S, Moritoh S, Furukawa Y, Mizuno T, Lim YM, Tsuda L, Nishida Y.

    Genetics   Vol. 176 ( 2 ) page: 927-936   2007.6

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    Allelic mutants exhibiting growth defects in Drosophila were isolated. Molecular cloning identified the responsible gene as a budding yeast Tim50 ortholog, and thus it was named tiny tim 50 (ttm50). The weak allele (ttm50(Gp99)) produced small flies due to reduced cell size and number, and growth terminated at the larval stage in the strong alleles (ttm50(IE1) and ttm50(IE2)). Twin-spot analysis showed fewer cells in ttm50(Gp99) clones, whereas ttm50(IE1) clones did not proliferate, suggesting that the gene has an essential cellular function. Tim50 is known to maintain mitochondrial membrane potential (MMP) while facilitating inner-membrane protein transport. We found that tagged Ttm50 also localized to mitochondria and that mitochondrial morphology and MMP were affected in mutants, indicating that mitochondrial dysfunction causes the developmental phenotype. Conversely, ttm50 overexpression increased MMP and apoptosis. Co-expression of p35 suppressed this apoptosis, resulting in cell overproliferation. Interestingly, ttm50 transcription was tissue specific, corresponding to elevated MMP in the larval midgut, which was decreased in the mutant. The correlation of ttm50 expression levels with differences in MMP match its proposed role in mitochondrial permeability barrier maintenance. Thus a mitochondrial protein translocase component can play active roles in regulating metabolic levels, possibly for modulation of physiological function or growth in development.

  2. Non-farnesylated B-type lamin can tether chromatin inside the nucleus and its chromatin interaction requires the Ig-fold region Reviewed

    Ryo Uchino, Shin Sugiyama, Motoi Katagiri, Yoshiro Chuman, Kazuhiro Furukawa

    Chromasoma   Vol. 126 ( 1 ) page: 125 - 144   2017.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00412-016-0581-x

    Web of Science

  3. Loss of Drosophila A-type lamin C initially causes tendon abnormality including disintegration of cytoskeleton and nuclear lamina in muscular defects Reviewed

    Ryo Uchino, Yu-ki Nonaka, Tuneyoshi Horigome, Shin Sugiyama, and Kazuhiro Furukawa

    Developmental Biology   Vol. 373 ( 1 ) page: 216-27   2013.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  4. Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila Reviewed

    Ziguang Liu, Shinya Matsuoka, Ami Enoki, Tsuyoshi Yamamoto, Kazuhiro Furukawa, Yasutoyo Yamasaki, Yasuyoshi Nishida, and Shin Sugiyama

    Development, Growth & Differentiation   Vol. 53 ( 6 ) page: 822-841   2011

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    Language:English   Publishing type:Research paper (scientific journal)  

  5. *A-type and B-type lamins initiate layer assembly at distinct areas of the nuclear envelope in living cells. Reviewed

    Furukawa K, Ishida K, Tsunoyama TA, Toda S, Osoda S, Horigome T, Fisher PA, Sugiyama S.

    Experimental Cell Research   Vol. 315 ( 7 )   2009

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    Language:English   Publishing type:Research paper (scientific journal)  

  6. *BAF as a caspase-dependent mediator of nuclear apoptosis in Drosophila Reviewed

    Furukawa K, Aida T, Nonaka Y, Osoda S, Juarez C, Horigome T, Sugiyama S.

    Journal of Structural Biology   Vol. 160 ( 2 ) page: 125-134   2007.11

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    Language:English   Publishing type:Research paper (scientific journal)  

  7. Essential roles of myosin phosphatase in the maintenance of epithelial cell integrity of Drosophila imaginal disc cells. Reviewed

    Mitonaka T, Muramatsu Y, Sugiyama S, Mizuno T, Nishida Y.

    Developmental Biology   Vol. 309 ( 1 ) page: 78-86   2007.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  8. Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. Reviewed

    Osouda S, Nakamura Y, de Saint Phalle B, McConnell M, Horigome T, Sugiyama S, Fisher PA, Furukawa K.

    Developmental Biology   Vol. 284 ( 1 ) page: 219-232   2005.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  9. Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila. Reviewed

    Furukawa K, Sugiyama S, Osouda S, Goto H, Inagaki M, Horigome T, Omata S, McConnell M, Fisher PA, Nishida Y.

    Journal of Cell Science   Vol. 116   page: 3811-3823   2003

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    Language:English   Publishing type:Research paper (scientific journal)  

  10. A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment. Reviewed

    Oishi I, Sugiyama S, Otani H, Yamamura H, Nishida Y, Minami Y.

    Mechanisms of Development   Vol. 71 ( 1-2 ) page: 49-63   1998.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  11. Identification of a Novel <u>Drosophila</u> Protein Kinase Highly Homologous to Protein Kinase N(PKN) Reviewed

    Ueno N, Oishi I, Sugiyama S, Nishida Y, Minami Y, Yamamura H.

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 232 ( 18 ) page: 126-127   1997

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    Language:English   Publishing type:Research paper (scientific journal)  

  12. A Novel <u>Drosophila</u> Receptor Tyrosine Kinase Expressed Specifically in the Nervous System Reviewed

    Oishi I, Sugiyama S, Liu ZJ, Yamamura H, Nishida Y, Minami Y.

    The Journal of Biological Chemistry   Vol. 272 ( 18 ) page: 11916-11923   1997

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    Language:English   Publishing type:Research paper (scientific journal)  

  13. The Raf/MAP kinase cascade in cell cycle regulation and differentiation in Drosophila. Invited

    Nishida Y, Inoue YH, Tsuda L, Adachi-Yamada T, Lim YM, Hata M, Ha HY, Sugiyama S.

    Cell Structure and Function   Vol. 21 ( 5 ) page: 437-444   1996.10

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    Language:English  

  14. Genes Involved in Segmentation

    PROTEIN, NUCLEIC ACID AND ENZYME   Vol. 38 ( 15 ) page: 2492-2504   1993

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    Language:English  

  15. *Cytoplasmic factors determining antevoposterior polarity in the Drosophila embryo Reviewed

    Sugiyama, S. and Okada, M.

    Development Genes and Evolution   Vol. 198   page: 402-410   1990.7

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    Authorship:Lead author   Language:English  

  16. *Analysis of cytoplasmic activity dependent on the Drosophila terminal pattern gene torso Reviewed

    Sugiyama S, Okada M.

    Developmental Biology   Vol. 141 ( 2 ) page: 299-305   1990

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

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Presentations 2

  1. ショウジョウバエ巨大精子の長さとミトコンドリアのサイズの解析

    杉山伸 植田沙織

    日本分子生物学会年会 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  2. ショウジョウバエのミトコンドリア内膜蛋白質輸送遺伝子ttm50による発生進行の制御

    杉山伸 西田育巧

    日本分子生物学会年会 

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    Event date: 2008.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

 

Social Contribution 1

  1. 福祉法人理事

    Role(s):Organizing member

    福祉法人みのりの会(名古屋市千種区山添町)  2021.4 - 2022.3