Bioscience and Biotechnology Center Professor

Updated on 2022/07/05
Doctor of Science ( 1987.3 The University of Tokyo )
Biotechnology
Reproductive Biochemistry
Developmental Biology
Molecular Biology
Biological Chemistry
Glycobiology
Others / Others / Glycobiology
Others / Others / Structured Biochemistry
Others / Others / Applied Molecular Cell Biology
Others / Others / Developmental Biology
Development of methods for diagnosis and treatment of mental disorders
シアロ糖鎖代謝異常によるヒト疾患の病理学的研究
Role of Surface Glycoconjugates in cell-cell Interaction.
生命情報のハードウェアを解析・構築する糖鎖生命情報科学の創出
Role of membrane microdomain in fertilization and early develpment
糖鎖機能の糖鎖工学的利用
名古屋大学 生物機能開発利用研究センター・教授
2004.4
Country:Japan
名古屋大学大学院生命農学研究科・教授(兼任)
2004.4
Country:Japan
名古屋大学 生物機能開発利用研究センター・助教授
2003.4 - 2004.3
Country:Japan
名古屋大学生命農学研究科・助教授(兼任)
2002.4 - 2004.3
Country:Japan
名古屋大学高等研究院・流動教員(兼任)
2002.2 - 2005.3
Country:Japan
名古屋大学 生物分子応答研究センター・助教授
2000.4 - 2003.3
Country:Japan
名古屋大学大学院生命農学研究科 助教授
1998.4 - 2000.3
Country:Japan
名古屋大学農学部 助教授
1996.6 - 1998.3
Country:Japan
東京大学大学院理学系研究科 助手
1994.4 - 1996.5
Country:Japan
東京大学理学部 助手
1989.4 - 1994.3
Country:Japan
日本学術振興会 特別研究員PD
1987.4 - 1989.3
Country:Japan
The University of Tokyo Graduate School, Division of Science Department of Biophysics and Biochemistry
1984.4 - 1987.3
Country: Japan
The University of Tokyo Graduate School, Division of Science Department of Biophyscs and Biochemistry
1982.4 - 1984.3
Country: Japan
The University of Tokyo Faculty of Science Department of Biophyscs and Biochemistry
1978.4 - 1982.3
Country: Japan
Japanese Society of Carbohydrate Research
2007.4
Japanese Society of Carbohydrate Research
1999.4
日本農芸化学会 中部支部会評議員
2008.4
日本生化学会
日本動物学会
Forum: Carbohydrate Coming of Age
2001.4 - 2008.3
Society for Glycobiology
日本分子生物学会
日本発生生物学会
Promotion Award of Japanese Society of Carbohydrate Sciences
1999.8
Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis
Kawanishi Kunio, Saha Sudeshna, Diaz Sandra, Vaill Michael, Sasmal Aniruddha, Siddiqui Shoib S., Choudhury Biswa, Sharma Kumar, Chen Xi, Schoenhofen Ian C., Sato Chihiro, Kitajima Ken, Freeze Hudson H., Munster-Kuhnel Anja, Varki Ajit
JOURNAL OF CLINICAL INVESTIGATION Vol. 131 ( 5 ) 2021.3
The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid
Yoshimura Atsushi, Hatanaka Rina, Tanaka Hiroshi, Kitajima Ken, Sato Chihiro
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 534 page: 1069 - 1075 2021.1
Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae
Saha Sudeshna, Coady Alison, Sasmal Aniruddha, Kawanishi Kunio, Choudhury Biswa, Yu Hai, Sorensen Ricardo U., Inostroza Jaime, Schoenhofen Ian C., Chen Xi, Munster-Kuhnel Anja, Sato Chihiro, Kitajima Ken, Ram Sanjay, Nizet Victor, Varki Ajit
MBIO Vol. 12 ( 1 ) 2021
The expression of sulfated sialic acids (SiaS) is dynamically regulated in mammalian cells
Kitajima Ken, Ertunc Nursah, Sato Chihiro
GLYCOBIOLOGY Vol. 30 ( 12 ) page: 1066 - 1067 2020.12
Sialic acid sulfation is induced by the antibiotic treatment in mammalian cells
Ertunc Nursah, Sato Chihiro, Kitajima Ken
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY Vol. 84 ( 11 ) page: 2311 - 2318 2020.11
Comparative Studies of Polysialic Acids Derived from Five Different Vertebrate Brains
Yang Yi, Murai Ryo, Takahashi Yuka, Mori Airi, Hane Masaya, Kitajima Ken, Sato Chihiro
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 21 ( 22 ) 2020.11
Polysialylation and disease Invited Reviewed
Mol Aspects Med 2020.8
Combinational Analyses with Multiple Methods Reveal the Existence of Several Forms of Polysialylated Neural Cell Adhesion Molecule in Mouse Developing Brains
Mori Airi, Yang Yi, Takahashi Yuka, Hane Masaya, Kitajima Ken, Sato Chihiro
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 21 ( 16 ) 2020.8
Systems glycomics of adult zebrafish Invited Reviewed International coauthorship
Ken Kitajima, Nao Yamakawa, Chihiro Sato, Yann Guerardel
Journal of Japanese Biochemical Society Vol. 92 ( 3 ) page: 349 - 359 2020.6
Discovery of a new sialic acid binding region that regulates Siglec-7
Yamakawa Nao, Yasuda Yu, Yoshimura Atsushi, Goshima Ami, Crocker Paul R., Vergoten Gerard, Nishiura Yuji, Takahashi Takashi, Hanashima Shinya, Matsumoto Kana, Yamaguchi Yoshiki, Tanaka Hiroshi, Kitajima Ken, Sato Chihiro
SCIENTIFIC REPORTS Vol. 10 ( 1 ) 2020.5
Identification and characterization of a novel, versatile sialidase from a Sphingobacterium that can hydrolyze the glycosides of any sialic acid species at neutral pH
Iwaki Yuya, Matsunaga Emiko, Takegawa Kaoru, Sato Chihiro, Kitajima Ken
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 523 ( 2 ) page: 487 - 492 2020.3
Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice
Ikegami Keisuke, Saigoh Kazumasa, Fujioka Atsuko, Nagano Mamoru, Kitajima Ken, Sato Chihiro, Masubuchi Satoru, Kusunoki Susumu, Shigeyoshi Yasufumi
SCIENTIFIC REPORTS Vol. 9 2019.9
Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D-2 and adenosine A(2A) receptors
Lin Chien-Yu, Lai Hsing-Lin, Chen Hui-Mei, Siew Jian-Jing, Hsiao Cheng-Te, Chang Hua-Chien, Liao Kuo-Shiang, Tsai Shih-Chieh, Wu Chung-Yi, Kitajima Ken, Sato Chihiro, Khoo Kay-Hooi, Chern Yijuang
TRANSLATIONAL PSYCHIATRY Vol. 9 2019.8
Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain
Abe Chikara, Yi Yang, Hane Masaya, Kitajima Ken, Sato Chihiro
SCIENTIFIC REPORTS Vol. 9 2019.7
Structural Diversity and Evolution of Sialic Acids
Kitajima Ken
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY Vol. 31 ( 181 ) page: SE18 - SE20 2019.7
N-linked mannose glycoconjugates on shrimp thrombospondin, pmTSP-II, and their involvement in the sperm acrosome reaction
Timklay Wauranittha, Magerd Sirilug, Sato Chihiro, Somrit Monsicha, Watthammawut Atthaboon, Senarai Thanyaporn, Weerachatyanukul Wattana, Kitajima Ken, Asuvapongpatana Somluk
MOLECULAR REPRODUCTION AND DEVELOPMENT Vol. 86 ( 4 ) page: 440 - 449 2019.4
Sialic Acids in Neurology
SIALIC ACIDS, PT II: BIOLOGICAL AND BIOMEDICAL ASPECTS Vol. 76 page: 1 - 64 2019
Technologies to Elucidate Functions of Glycans
Furukawa Koichi, Ohmi Yuhsuke, Kondo Yuji, Ohkawa Yuki, Tajima Orie, Furukawa Keiko, Honke Koichi, Inokuchi Jin-ichi, Gu Jianguo, Kadomatsu Kenji, Nadanaka Satomi, Kitagawa Hiroshi, Nishihara Shoko, Nomura Kazuya, Oka Shogo, Ito Makoto, Kitajima Ken, Natsuka Shunji, Kanagawa Motoi, Ishimizu Takeshi, Fujiyama Kazuhito, Chiba Yasunori, Osada Hiroyuki
GLYCOSCIENCE: BASIC SCIENCE TO APPLICATIONS: INSIGHTS FROM THE JAPAN CONSORTIUM FOR GLYCOBIOLOGY AND GLYCOTECHNOLOGY (JCGG) page: 87 - 124 2019
Sialic Acids in Neurology Invited Reviewed
Sato C, Kitajima K
Adv Carbohydr Chem Biochem Vol. 76 page: 1 - 64 2019
Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns
Yamakawa Nao, Vanbeselaere Jorick, Chang Lan-Yi, Yu Shin-Yi, Ducrocq Lucie, Harduin-Lepers Anne, Kurata Junichi, Aoki-Kinoshita Kiyoko F., Sato Chihiro, Khoo Kay-Hooi, Kitajima Ken, Guerardel Yann
NATURE COMMUNICATIONS Vol. 9 2018.11
Positive selection on schizophrenia-associated ST8SIA2 gene in post-glacial Asia
Fujito Naoko T., Satta Yoko, Hane Masaya, Matsui Atsushi, Yashima Kenta, Kitajima Ken, Sato Chihiro, Takahata Naoyuki, Hayakawa Toshiyuki
PLOS ONE Vol. 13 ( 7 ) 2018.7
ポリシアル酸化 Invited Reviewed
佐藤ちひろ、北島健
膜タンパク質; 特集 「タンパク質・核酸の分子修飾 Ⅲ. 細胞膜での分子修飾」)生体の科学 Vol. 69 ( 5 ) page: 502 - 503 2018
Identification of KDN-Gangliosides
Kitajima Ken
GANGLIOSIDES: METHODS AND PROTOCOLS Vol. 1804 page: 429 - 435 2018
Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4
Mori Airi, Hane Masaya, Niimi Yuki, Kitajima Ken, Sato Chihiro
GLYCOBIOLOGY Vol. 27 ( 9 ) page: 834-846 2017.9
Invisible glycoproteins with unusually high carbohydrate content in animal gametic cells
Kitajima Ken
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Vol. 254 2017.8
Chemical Synthesis and Evaluation of a Disialic Acid-Containing Dextran Polymer as an Inhibitor for the Interaction between Siglec 7 and Its Ligand
Yamaguchi Sho, Yoshimura Atsushi, Yasuda Yu, Mori Airi, Tanaka Hiroshi, Takahashi Takashi, Kitajima Ken, Sato Chihiro
CHEMBIOCHEM Vol. 18 ( 13 ) page: 1194-1203 2017.7
Alpha-2 macroglobulin as a region-specific secretory protein in male reproductive tract, and its dynamics during sperm transit toward the female spermatheca in the blue crab
Senarai Thanyaporn, Vanichviriyakit Rapeepun, Miyata Shinji, Sato Chihiro, Sretarugsa Prapee, Weerachatyanukul Wattana, Kitajima Ken
MOLECULAR REPRODUCTION AND DEVELOPMENT Vol. 84 ( 7 ) page: 585-595 2017.7
Chlorpromazine Increases the Expression of Polysialic Acid (PolySia) in Human Neuroblastoma Cells and Mouse Prefrontal Cortex
Abe Chikara, Nishimura Saki, Mori Airi, Niimi Yuki, Yang Yi, Hane Masaya, Kitajima Ken, Sato Chihiro
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 18 ( 6 ) 2017.6
Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation
Go Shinji, Go Shiori, Veillon Lucas, Ciampa Maria Grazia, Mauri Laura, Sato Chihiro, Kitajima Ken, Prinetti Alessandro, Sonnino Sandro, Inokuchi Jin-ichi
JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 292 ( 17 ) page: 7040-7051 2017.4
Diverse subcellular localizations of the insect CMP-sialic acid synthetases
Di Wu, Fujita Akiko, Hamaguchi Kayo, Delannoy Philippe, Sato Chihiro, Kitajima Ken
GLYCOBIOLOGY Vol. 27 ( 4 ) page: 329-341 2017.4
Synthesis of end-functionalized glycopolymers containing alpha(2,8) disialic acids via pi-allyl nickel catalyzed coordinating polymerization and their interaction with Siglec-7
Ohira Shuichi, Yasuda Yu, Tomita Ikuyoshi, Kitajima Ken, Takahashi Takashi, Sato Chihiro, Tanaka Hiroshi
CHEMICAL COMMUNICATIONS Vol. 53 ( 3 ) page: 553-556 2017.1
Synthesis of End-functionalized Glycopolymers Containing α(2,8) Disialic Acids by π-Allyl Nickel Catalyzed Coordinating Polymerization and Their Interaction with Siglec-7.
Ohira S, Yasuda Y, Tomita I, Kitajima K, Takahashi T, Sato C, Tanaka H.
Vol. 53 ( 3 ) page: 553-556 2017.1
Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.
Go S, Go S*, Veillon L, Ciampa MG, Mauri L, Sato C, Kitajima K, Prinetti A, Sonnino S, Inokuchi JI.
J Biol Chem. 2017
Diverse subcellular localizations of the insect CMP-sialic acid synthetases
Wu D, Fujita A, Hamaguchi K, Delannoy P, Sato C, Kitajima K.
page: Epub ahead of print 2016.12
Relationship between ST8SIA2, polysialic acid and its binding molecules, and psychiatric disorders.
Sato C, Hane M, Kitajima K.
Biochim Biophys Acta. Vol. 1860 ( 8 ) page: 1739-1752 2016
The AMOR Arabinogalactan Sugar Chain Induces Pollen-Tube Competency to Respond to Ovular Guidance.
Mizukami AG, Inatsugi R, Jiao J, Kotake T, Kuwata K, Ootani K, Okuda S, Sankaranarayanan S, Sato Y, Maruyama D, Iwai H, Garénaux E, Sato C, Kitajima K, Tsumuraya Y, Mori H, Yamaguchi J, Itami K, Sasaki N, Higashiyama T.
Curr Biol. Vol. 26 ( 8 ) page: 1091-1097 2016
Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.
Hane M**, Kitajima K, Sato C.
Biochem Biophys Res Commun Vol. 478 ( 3 ) page: 1123-1129 2016
Discovery, primary and crystal structures, and capacitation-related properties of a prostate-derived heparin-binding protein WGA16 from boar sperm.
Garénaux E, Kanagawa M, Tsuchiyama T, Hori K, Kanazawa T, Goshima A, Chiba M, Yasue H, Ikeda A, Yamaguchi Y, Sato C, and Kitajima K.
J. Biol. Chem. Vol. 290 ( 9 ) page: 5484-5501 2015
Protective effects of polysialic acid on proteolytic cleavage of FGF2 and ProBDNF/BDNF
Hane M*, Matsuoka S**, Ono S**, Miyata S, Kitajima K, Sato C.
Vol. 25 ( 10 ) page: 1112-1124 2015
Ganglioside contained in the neuronal tissue-enriched acidic protein of 22 kDa (NAP-22) fraction prepared from the detergent-resistant membrane microdomain of rat brain inhibits the phosphatase activity of calcineurin.
Kobayashi Y, da Silva R, Kumanogoh H, Miyata S, Sato C, Kitajima K, Nakamura S, Morita M, Hayashi F, Maekawa S.
Vol. 93 ( 9 ) page: 1462-1470 2015
Sulfatide-Hsp70 interaction promotes Hsp70 clustering and stabilizes binding to unfolded protein.
Harada Y**, Sato C, and Kitajima K.
Vol. 5 ( 2 ) page: 958-973 2015
Rapid trimming of cell surface polysialic acid (polySia) by exovesicular sialidase triggers release of preexisting surface neurotrophin.
Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OM, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K, and Sato C.
J. Biol. Chem. Vol. 290 ( 21 ) page: 13202-13214 2015
Disialic, oligosialic and polysialic acids: distribution, functions and related disease Reviewed
Sato C, Kitajima K
Journal of Biochemistry Vol. 154 ( 2 ) page: 115-136 2014.6
Comparison of analytical methods to detect polysialic acid. Reviewed
Nishimura S, Hane M, Niimi Y, Miyata S, Kitajima K, and Sato C
Journal of Glycomics and Lipidomics Vol. 4 ( 2 ) page: 113 2014
Interaction of 70-kDa heat shock protein with glycosaminoglycans and acidc glycopolymers. Reviewed
Harada Y, Garenaux E, Nagatsuka T, Uzawa H, Nishida Y, Sato C, Kitajima K
Biochem Biophys Res Commun. Vol. 453 page: 229-234 2014
Polysialic acid: Biosynthesis, novel functions and applications. Reviewed
Colley K, Kitajima K, Sato C
Critical Reviews in Biochemistry and Molecular Biology page: 1-35 2014
Identification of novel isoforms of vitellogenin expressed in ascidian eggs. Reviewed
Akasaka M, Kato KH, Kitajima K, Sawada H.
J Exp Zool Part B Mol Dev Evol. Vol. 320 ( 2 ) page: 118-128 2013
Occurrence of free deaminoneuraminic acid (KDN)-containing complex-type N-glycans in human prostate cancers. Reviewed
Yabu M, Korekane H, Takahashi H, Ohigashi H, Ishikawa O, Hatano K, Nonomura N, Sato C, Kitajima K, Miyamoto Y.
Glycobiology Vol. 26 ( 6 ) page: 634-642 2013
Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid. Reviewed
Ono S, Hane M, Kitajima K, Sato C.
J Biol Chem. Vol. 287 ( 6 ) page: 3710-3722 2012
Pig sperm membrane microdomains contain a highly glycosylated 15-25-kDa wheat germ agglutinin-binding protein. Reviewed
Kasekarn W, Kanazawa T, Hori K, Tsuchiyama T, Xue L, Garénaux E, Kongmanas K, Tanphaichitr N, Yasue H, Sato C, Kitajima K.
Biochem. Biophys. Res. Commun. Vol. 426 ( 3 ) page: 356-362 2012
Metabolism of Vertebrate Amino Sugars with N-glycolyl Groups: Resistance of α2-8-linked N-glycolylneuraminic Acid to Enzymatic Cleavage. Reviewed
Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woods R, Varki A.
J Biol Chem. Vol. 287 ( 34 ) page: 28917-28931 2012
Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons. Reviewed
Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T.
J Biol Chem. Vol. 287 ( 18 ) page: 14816-14826 2012
Structural and functional impairments of polysialic acid (polySia)-neural cell adhesion molecule (NCAM) synthesized by a mutated polysialyltransferase of a schizophrenic patient. Reviewed
Hane M, Sumida M, Kitajima K, Sato C
Pure Appl Chem. Vol. 84 ( 9 ) page: 1895-1906 2012
Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution. Reviewed
Guérardel Y, Chang LY, Fujita A**, Coddeville B, Maes E, Sato C, Harduin-Lepers A, Kubokawa K, Kitajima K.
Glycobiology Vol. 22 ( 4 ) page: 479-491 2012
Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid. Reviewed
Ono, S., Hane, M., Kitajima, K., and Sato, C.
J Biol Chem. Vol. 287 ( 6 ) page: 3710-3722 2012
New function of polysialic acid and its involvement in neural activities. Invited Reviewed
Sato, C., and Kitajima, K.
Seikagaku Vol. 83 ( 3 ) page: 189-196 2011.3
Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia Reviewed
Isomura, R, Kitajima, K., and Sato, C.
Journal of Biological Chemistry Vol. 286 ( 24 ) page: 21535-21545 2011
New function of polysialic acid and its relationship to schizoprenia. Invited Reviewed
Sato, C., and Kitajima, K.
Trends Glycsci Glycotech Vol. 23 ( 133 ) page: 221-238 2011
Mechanism regulating Ca2+-dependent mechanosensory behaviour in sea urchin spermatozoa. Reviewed
Kambara, Y., Shiba, K., Yoshida, M., Sato, C., Kitajima, K., and Shingyoji, C.
Cell Struct Funct Vol. 36 ( 1 ) page: 69-82 2011
Co-expression of two distinct polysialic acids, α2,8- and α2,9-linked polymers of N-acetylneuraminic acid, in distinct glycoproteins and glycolipids in sea urchin sperm Reviewed
Miyata, S., Yamakawa, N., Toritama, M., Sato, C., and Kitajima, K.
Glycobiology Vol. 21 ( 12 ) page: 1596-1605 2011
Extensive enrichment of N-glycolylneuraminic acid in extracellular sialoglycoproteins abundantly synthesized and secreted by human cancer cells. Reviewed
Sadako Inoue, Chihiro Sato., and Ken Kitajima
Glycobiology Vol. 20 page: 752-762 2010
Survival signals of hepatic stellate cells in liver regeneration are regulated by glycosylation changes in rat vitronectin, especially decreased sialylation. Reviewed
Kotone Sano, Yasunori Miyamoto, Nana Kawasaki, Noritaka Hashii, Satsuki Itoh, Misaki Murase, Kimie Date, Miki Yokoyama, Chihiro Sato, Ken Kitajima, and Haruko Ogawa
J. Biol. Chem. Vol. 285 page: 17301-17309 2010
Developmental stage-dependent expression of an α2,8- trisialic acid unit on glycoproteins in mouse brain. Reviewed
Inoko, E., Nishiura, Y., Tanaka, H., Takahashi, T., Furukawa, K., Kitajima, K., and Sato, C.
Glycobiology Vol. 20 page: 916-928 2010
Human KDN (deaminated neuraminic acid) and its elevated expression in cancer cells: mechanism and significance. Reviewed
Inoue, S., Kitajima, K., Sato, C., and Go, S.
Adv Exp Med Biol Vol. 705 page: 669-678 2010
*Membrane microdomains from early gastrula embryos of medaka, Oryzias latipes are a plat form of E-cadherin and carbohydrate-mediated cell-cell interactions during epiboly Reviewed
Adachi T., Sato, C., Kishi, Y., Totani, K., Murata, T., Usui, T., and Kitajima, K
Glycoconjugate J Vol. 26 page: 285-99 2009
Complex formation of a brain-derived neurotrophic factor and glycosaminoglycans. Reviewed
Kanato, Y., Ono, S., Kitajima, K. and Sato, C.
Biosci. Biotech. Biosci. Vol. 73 page: 2735-2741 2009
Developmental regulation of oligosialylation in zebrafish. Reviewed
Chang LY, Harduin-Lepers A, Kitajima K, Sato C, Huang CJ, Khoo KH, Guérardel Y.
Glycoconjugate J Vol. 26 page: 247-61 2009
Direct binding of polysialic acid to a brain-derived neurotrphic factor depends on the degree of polymerization. Reviewed
Kanato, Y., Kitajima, K. Sato, C.
Glycobiology Vol. 12 page: 1044-1053 2008
Identification of an inflammation-inducible serum protein recognized by anti-disialic acid antibodies as carbonic anhydrase II Reviewed
Yasukawa, Z., Sato, C., and Kitajima, K.
J. Biochem. Vol. 141 page: 429-441 2007
Glycobiology of polysialic acids on sea urchin gametes Reviewed
Miyata, S., Sato, C., and Kitajima, K.
Trends Glycosci. Glycotech. Vol. 19 page: 83-95 2007
*Membrane microdomain formation is crucial in epiboly during gastrulation of medaka. Reviewed
Adachi, T., Sato, C., and Kitajima, K.
Biochem. Biophys. Res. Commun. Vol. 358 page: 848-853 2007
Development of sensitive chemical and immunochemical methods for detecting sulfated sialic acids and their application to glycoconjugates from sea urchin sperm and eggs Reviewed
Yamakawa, N., Sato, C., Miyata, S., Maehashi, E., Toriyama, M, Sato, N, Furuhata, K., and Kitajima, K.
Biochimie Vol. 89 page: 1396-1408 2007
*Hypoxia-enhanced expression of free deaminoneuraminic acid in human cancer cells Reviewed
Go, S., Sato, C., Yin, J., Kannagi, R., and Kitajima, K.
Biochem. Biophys. Res. Commun. Vol. 357 page: 537-542 2007
*Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase Reviewed
Fujita , A., Sato, C., and Kitajima, K.
Biochem. Biophys. Res. Commun. Vol. 355 page: 174-180 2007
Complex formation of 70-kDa heat shock protein with acidic glycolipids and phospholipids Reviewed
Harada, Y., Sato, C., and Kitajima, K.
Biochem. Biophys. Res. Commun. Vol. 353 page: 655-660 2007
The rainbow trout CMP-sialic acid synthetase utilizes a nuclear localization signal different from that identified in the mouse enzyme. Reviewed
Tiralongo J, Fujita A, Sato C, Kitajima K, Lehmann F, Oschlies M, Gerardy-Schahn R, Münster-Kühnel AK.
Glycobiology Vol. 17 page: 945-954 2007
Oral ingestion of mannose alters the expression level of deaminoneuraminic acid (KDN) in mouse organs Reviewed
Go, S., Sato, C., and Kitajima, K.
Glycoconjugate J. Vol. 23 page: 409-419 2006
*Flagellasialin: a novel sulfated alpha2,9-linked polysialic acid glycoprotein of sea urchin sperm flagella Reviewed
Miyata, S., Sato, C., Kumita, H., Toriyama, M., Vacquier, V. D., and Kitajima, K.
Glycobology Vol. 166 page: 1229-1241 2006
KDN (Deaminated neuraminic acid): Dreamful past and exciting future of the newest member of the sialic acid family Reviewed
Inoue, S. and Kitajima, K.
Glycoconjugate J. Vol. 23 page: 277-290 2006
Involvement of the alpha2,8-Polysialyltransferases II/STX and IV/PST in the Biosynthesis of Polysialic Acid Chains on the O-Linked Glycoproteins in Rainbow Trout Ovary Reviewed
Asahina, S., Sato, C., Matsuno, M., Matsuda, T., Colley, K., and Kitajima, K.
J. Biochem. Vol. 140 page: 687-701 2006
Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands, as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activity Reviewed
Nakatani, H., Aoki, N., Nakagawa, Y., Jin-No, S., Aoyama K, Oshima, K., Ohira, S., Sato, C., Nadano, D., Matsuda, T.
Biochem J. Vol. 395 page: 21-30 2006
Hypoxic culture induces expression of Sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells Reviewed
Yin, J., Hashimoto, A., Izawa, M., Miyazaki, K., Chen G-Y., Takematsu, H., Kozutsumi, Y., Suzuki, A., Furuhata, K., Cheng, F.-L. Lin, C.-H., Sato, C., Kitajima, K., and Kannagi, R.
Cancer Res. Vol. 66 page: 2937-2945 2006
N-Linked oligosaccharides on chondroitin 6-sulfotransferase-1 are required for production of the active enzyme, golgi localization, and sulfotransferase activity toward keratan sulfate Reviewed
Yusa, A., Kitajima, K., and Habuchi, O.
J. Boil. Chem. Vol. 281 page: 20393-20403 2006
Identification of disialic acid-containing glycoproteins in mouse serum: a novel modification of immunoglobulin light chains, vitronectin, and plasminogen Reviewed
Yasukawa, Z., Sato, C., Sano, K., Ogawa, H. and Kitajima, K.
Glycobiology Vol. 166 page: 651-665 2006
Development of a simple and efficient method for assaying cytidine monophosphate sialic acid synthetase activity using an enzymatic reduced nicotinamide adenine dinucleotide/oxidized nicotinamide adenine dinucleotide converting system Reviewed
Fujita, A., Sato, C., Munster-Kuhnel, A.-K., Gerardy-Schahn, R., and Kitajima, K.
Anal. Biochem. Vol. 337 page: 12-21 2005
Inflammation-dependent changes in α2,3-, α2,6-, and α2,8-sialic acid glycotopes on serum glycoproteins in mouse Reviewed
Yasukawa, Z., Sato, C., and Kitajima, K.
Glycobiology Vol. 15 page: 827-837 2005
Distal myopathy with rimmed vaculoes: Impared O-glycan formation in muscular glycoproteins Reviewed
Tajima, Y., Uyama, E., Go, S., Sato, C., Tao, N., Kotani, M., Hino, H., Suzuki, A., Sanai, Y., Kitajima, K., and Sakuraba, H.
Amer. J. Pathol. Vol. 166 page: 1121-1130 2005
Probing a CMP-Kdn synthetase by 1H, 31P and STD NMR spectroscopy Reviewed
Haselhorst, T., Munster-Kuhnel, A.-K., Stolz, A., Oschlies, M., Tiralongo, J., Kitajima, K., Gerardy-Schahn, R., and von Itzstein, M.
Biochem. Biophys. Res. Commun. Vol. 327 page: 565-570 2005
N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulfotransferase-1 Reviewed
Yusa, A., Kitajima, K., and Habuchi, O.
Biochem. J. Vol. 388 page: 115-121 2005
A major flagellum sialoglycoprotein in sea urchin sperm contains a novel polysialic acid, an α2,9-linked poly-N-acetylneuraminic acid chain, capped by an 8-O-sulfated sialic acid residue Reviewed
Miyata, S., Sato, C., Kitamura, S., Toriyama, M.,and Kitajima, K.
Glycobiology Vol. 141 page: 827-840 2004
受精・発生と糖鎖認識の研究における最近の発展 Reviewed
北島健
生化学 Vol. 76 page: 191-200 2004
Specificity of human trans-sialidase as probed with gangliosides. Reviewed
Nikonova, E.Y., Tertov, V.V., Sato C, Kitajima K, and Bovin, N.V.
Bioorg Med Chem. Lett. Vol. 141 page: 5161-5164 2004
Alpha-C-Mannosyltryptophan is not recognized by conventional mannose-binding lectins Reviewed
Nishikawa T, Kajii S, Sato C, Yasukawa Z, Kitajima K, and Isobe M.
Bioorg Med Chem. Vol. 12 page: 2343-2348 2004
Surface plasmon resonance study of carbohydrate-carbohydrate interaction between various gangliosides and Gg3-carrying polystyrene Reviewed
Matsuura, K., Oda, R., Kitakouji, H., Kiso, M., Kitajima, K., and Kobayashi, K.
Biomacromolecules Vol. 5 page: 937-941 2004
A newly identified zona pellucida glycoprotein, ZPD, and domeric ZP1 of chicken egg envelope are involved in sperm activation on sperm-egg Reviewed
Okumura, H., Khono, Y., Iwata, Y., Mori, H., Aoki, N., Sato, C., Kitajima, K., Nadano, D., and Matsuda, T.
Biochem. J. Vol. 384 page: 191-199 2004
Developmental expression of a sialyltransferase responsible for sialylation of cortical alveolus glycoprotein during oogenesis in rainbow trout (Oncorhynchus mykiss) Reviewed
Asahina, S., Sato, C., and Kitajima, K.
J. Biochem. (Tokyo) Vol. 136 page: 189-198 2004
"A 33-kDa allergen from rice (Oryza sativa L. Japonica). cDNA cloning, expression, and identification as a novel glyoxalase I."
"Usui, Y., Nakase, M., Hotta, H., Urisu, A., Aoki, N., Kitajima, K., and Matsuda, T."
J. Biol. Chem. Vol. 276 page: 11376-11381 2002.2
Morphological and biochemical changes of isolated chicken egg-envelope during sperm penetration: Degradation of the 97 kilodalton glycoprotein is involved in sperm-driven hole formation on the egg-envelope.
"Takeuchi, Y., Cho, R., Iwata, Y., Nishimura, K., Kato, T., Aoki, N., Kitajima, K., and Matsuda, T."
Biology of Reproduction Vol. 64 page: 822-830 2001.1
Molecular cloning of a unique CMP-sialic acid synthetase which effectively utilizes both deaminoneuraminic Acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates.
"Nakata, D., Munster, A.-K., Gerardy-Schahn, R., Aoki, N., Matsuda, T., and Kitajima, K."
Glycobiology Vol. 11 page: 685-692 2001.1
"Detection of di-, oligo-, and polysialic acid in glycoproteins."
"Sato, C., Kitajima, K."
Recent Research Developments in Analytical Biochemistry Vol. "Transworld Research Network Publisher, India" page: in press 2001.1
Occurrence of oligosialic acids on integrin alpha-5 subunit and thier involvement in cell adhesion to fibronectin.
"Nadanaka, S., Sato, C., Kitajima, K., Katagiri, K., Irie, S., and Yamagata, T."
Journal of Biological Chemistry Vol. 276 page: 33657-33664 2001.1
"Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q."
"Sato, C., Yasukawa, Z., Honda, N., Matsuda, T., and Kitajima, K."
Journal of Biological Chemistry Vol. 276 page: 28849-28856 2001.1
CA15. Oligosialic acid as a differentiation-associated antigen in human haemotoietic cell line HL60. Part 4 Carbohydrate and lectin.
"Sato, C., Matsuda, T., and Kitajima, K."
"Leucocyte typing VII (Mason et al., eds)" page: in press 2001.1
CA3. Carbohydrate-recognizing monoclonal antibodies as revealed by ELISA using phosphatidylethanolamine-conjugated oligosacharides as antigens. Part 4 Carbohydrate and lectin.
"Sato, C., Matsuda, T., and Kitajima, K."
"Leucocyte typing VII (Mason et al., eds)" page: in press 2001.1
Carbohydrate-recognizing monoclonal antibodies as revealed by ELISA using phosphatidylethanolamine-conjugated oligosacharides as antigens.
Leucocyte typing VII (Mason et al., eds), Oxford University Press page: in press 2001
Occurrence of oligosialic acids on integrin alpha-5 subunit and thier involvement in cell adhesion to fibronectin.
J. Biol. Chem. Vol. 276 page: 33657-33664 2001
Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q.
J. Biol. Chem. Vol. 276 page: 28849-28856 2001
Molecular cloning of a unique CMP-sialic acid synthetase which effectively utilizes both deaminoneuraminic acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates
Glycobiology Vol. 11 page: 685-692 2001
Detection of di-, oligo-, and polysialic acid in glycoproteins.
Recent Research Developments in Analytical Biochemistry page: in press 2001
Oligosialic acid as a differentiation-associated antigen in human haemotoietic cell line HL60.
Leucocyte typing VII (Mason et al., eds), Oxford University Press page: in press 2001
Morphological and biochemical changes of isolated chicken egg-envelope during sperm penetration: Degradation of the 97 kilodalton glycoprotein is involved in sperm-driven hole formation on the egg-envelope.
Biol. Reprod. Vol. 64 page: 822-830 2001
"Co-localization of receptor and transducer proteins in the glycosphingolipid-enriched, low density, detergent-insoluble membrane fraction of sea urchin sperm."
"Ohta, K., Sato, C., Matsuda, T., Toriyama, M., Vacquier, V. D., Lennarz, W. J., and Kitajima, K."
Glycoconjugate Journal Vol. 17 page: 205-214 2000.1
"Frequent occurrence of pre-existing alpha2,8-linked disialic and oligosialic acids with chain lengths up to 7 Sia residues in mammalian brain glycoproteins. Prevalence revealed by highly sensitive chemical methods and anti-di-, oligo, and polysialic acid antibodies specific for defined chain lengths."
"Sato, C., Fukuoka, H., Ohta, K., Matsuda, T., Koshino, R., Kobayashi, K., Troy, F. A. II,, and Kitajima, K."
Journal of Biological Chemistry Vol. 275 page: 15422-15431 2000.1
Lipid raft on gametic cells as a functional domain for sperm-egg interaction coupled with signal transduction.
"Ohta, K., Sato, C., Matsuda, T., Toriyama, M., Vacquier, V. D., Hirohashi, N., Lennarz, W. J., and Kitajima, K."
Zygote Vol. 8 (Suppliment) page: S56 2000.1
Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which has not the deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
"Nakata, D., Close, B. E., Colley, K. J., Matsuda, T., and Kitajima, K."
Biochemical and Biophysical Research Communication Vol. 273 page: 642-648 2000.1
細胞間接着における糖鎖-糖鎖相互作用
北島健
"季刊「化学総説」季刊「化学総説」No. 48「糖鎖分子の設計と生理機能」日本化学会編,学会出版センター,pp.199-207" Vol. "48「糖鎖分子の設計と生理機能」日本化学会編,学会出版センター" page: pp.199-207 2000.1
Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which has not the deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
Biochem. Biophys. Res. Commun. Vol. 273 ( 2 ) page: 642-648 2000
Lipid raft on gametic cells as a functional domain for sperm-egg interaction coupled with signal transduction.
Zygote Vol. 8 page: S56 2000
Co-localization of receptor and transducer proteins in the glycosphingolipid-enriched, low density, detergent-insoluble membrane fraction of sea urchin sperm.
Glycoconjugate Journal Vol. 17 page: 205-214 2000
Frequent occurrence of pre-existing alpha-2,8-linked disialic and oligosialic acids with chain lengths up to 7 Sia residues in mammalian brain glycoproteins: Prevalence revealed by highly sensitive chemical methods and anti-di-, oligo, and polysialic acid antibodies specific for defined chain lengths.
J. Biol. Chem. Vol. 275 page: 15422-15431 2000
細胞間接着における糖鎖-糖鎖相互作用
季刊化学総説「糖鎖分子の設計と生理機能」 Vol. 48 page: 199-207 2000
"A 42-kDa glycoprotein from chicken egg-envelope, an avian homolog of the ZPC family glycoproteins in mammalian zona pellucida. Its first identification, cDNA cloning and granulosa cell-specific expression."
"Takeuchi, T., Nishimura, K., Aoki, N., Adachi, T., Sato, C., Kitajima, K., and Matsuda, T."
European Journal of Biochemistry Vol. 273 page: 21526-21530 1999.1
Glycobiology of di and oligosialyl glycotopes.
"Sato, C., and Kitajima, K."
Trends in Glycoscience Glycotechnology Vol. 11 page: 371-390 1999.1
Cholesterol-dependent localization of NAP-22 on a neuronal membrane microdomain (Raft).
"Maekawa, S., Sato, C., Kitajima, K., Kumanogoh, H., Funatsu, N., and Sokawa, Y."
Journal of Biological Chemistry Biological Vol. 274 page: 21369-21374 1999.1
Isolation and characterization of low density detergent-insoluble membrane (LD-DIM) fraction from sea urchin sperm.
"Ohta, K., Sato, C., Matsuda, T., Toriyama, M., Lennarz W. J., and Kitajima, K."
Biochemical and Biophysical Research Communication Vol. 258 page: 616-623 1999.1
Lactation-dependent expression of an mRNA splice variant with an exon for a multiply O-glycosylated domain of mouse milk fat glubule glycoprotein MFG-E8.
"Oshima, K., Aoki, N., Negi, M., Kishi, M., Kitajima, K., and Matsuda, T."
Biochemical and Biophysical Research Communication Vol. 254 page: 522-528 1999.1
Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and Characterization of a KDN-9-phosphate Synthetase Activity from Trout Testis.
"Angata, T., Nakata, D., Matsuda, T., Kitajima, K., and Troy, F. A. II"
Journal of Biological Chemistry Vol. 274 page: 22949-22956 1999.1
Identification of two discrete peptide:N-glycanases in Oryzias latipes during embryogenesis.
"Seko, A., Kitajima, K., Iwamatsu, T., Inoue, S., and Inoue, Y."
Glycobiology Vol. 9 page: 887-895 1999.1
Elevated expression of free deaminoneuraminic in mammalian cells cultured in mannose-rich media.
"Angata, T., Nakata, D., Matsuda, T., and Kitajima, K."
Biochemical and Biophysical Research Communication Vol. 261 page: 326-331 1999.1
Fluorescent-assisted detection of oligosialyl units glycoconjugates.
"Sato, C., Inoue, S., Matsuda, T., and Kitajima, K.,"
Analytical Biochemistry Vol. 266 page: 102-109 1999.1
Fluorescent-assisted detection of oligosialyl units in glycoconjugates.
"Sato, C., Inoue, S., Matsuda, T., and Kitajima, K."
Analytical Biochemistry Vol. 267 page: 102-109 1999.1
Occurrence of a2ョ8-linked oligosialic acid residues in mammalian glycoproteins.
"Kitajima, K., Sato, C., Honda, N., Matsuda, T., Yokoyama, M.-H., Close, B. E., and Colley, K. J."
Sialobiology and Other novel Form of Glycosylation Vol. "a monograph (Inoue, Y., Lee, Y. C., and Troy, F. A., eds), , Gakushin Syuppan, Osaka, Japan" page: pp.69-76 1999.1
Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis.
J. Biol. Chem. Vol. 274 page: 22949-22956 1999
Lactation-dependent expression of an mRNA splice variant with an exon for a multiply O-glycosylated domain of mouse milk fat glubule glycoprotein MFG-E8.
Biochem. Biophys. Res. Commun. Vol. 254 page: 522-528 1999
Cholesterol-dependent localization of NAP-22 on a neuronal membrane microdomain (Raft).
J. Biol. Chem. Vol. 274 page: 21369-21374 1999
Identification of two discrete peptide:N-glycanases in Oryzias latipes during embryogenesis.
Glycobiology Vol. 9 page: 887-895 1999
Elevated expression of free deaminoneuraminic in mammalian cells cultured in mannose-rich media.
Biochem. Biophys. Res. Commun. Vol. 261 page: 326-331 1999
Fluorescent-assisted detection of oligosialyl units in glycoconjugates.
Analytical Biochemistry Vol. 266 page: 102-109 1999
Glycobiology of di and oligosialyl glycotopes.
Trends Glycosci. Glycotechnol. Vol. 11 page: 371-390 1999
Isolation and characterization of low density detergent-insoluble membrane (LD-DIM) fraction from sea urchin sperm.
Biochem. Biophys. Res. Commun. Vol. 258 page: 616-623 1999
A 42-kDa glycoprotein from chicken egg-envelope, an avian homolog of the ZPC family glycoproteins in mammalian zona pellucida. Its first identification, cDNA cloning and granulosa cell-specific expression.
Eur. J. Biochem. Vol. 273 page: 21526-21530 1999
A method for determination of UDP-GlcNAc: GlcNAcβ1-6(GlcNAcβ1-2)Man1-R[GlcNAc to Man] β1-4N-acetylglucosaminyl transferase VI activity using a pyridylaminated tetraantennary oligosaccharide as an acceptor substrate.
"Taguchi, T., Ogawa, T., Kitajima, K., Inoue, S., Inoue, Y., Ihara, Y., Sakamoto, Y., Nagai, K., and Taniguchi, N.,"
Analytical Biochemistry Vol. 255 page: 155-157 1998.1
"Cloning a expression of an α-2,8-polysialyltransferase (STX) from Xenopus laevis."
"Kudo, M., Takayama, E., Tashiro, K., Fukamachi, H., Nakata, T., Tadakuma, T., Kitajima, K., Inoue, Y., and Shiokawa, K.,"
Glycobiology Vol. 8 page: 771-777 1998.1
Avian egg coat glycoproteins: identification and characterization of homologues of mammalian zona pellucida glycoproteins.
"Matsuda, T., Nishimura, K., Tsuda, T., Takeuchi, Y., Adachi, T., Aoki, N., and Kitajima, K."
Zygote Vol. 6 page: S80-S81 1998.1
Development of an enzyme-linked immunoadsorbent assay- based method for measuring galactosyltransferase activity using a synthetic glycopolymer acceptor substrate.
"Oubihi, M., Kitajima, K., Kobayashi, K., Adachi, T., Aoki, N., and Matsuda, T.,"
Analytical Biochemistry Vol. 257 page: 169-175 1998.1
"Iuction of KDNase Sm, a deaminoneuraminic acid (KDN) residue-specific sialidase from Sphingobacterium multivorum, using synthetic KDN-glycosides."
"Fuchizawa, S., Furuhata, K., Matsuda, T., and Kitajima, K.,"
Biochemical and Biophysical Research Communication Vol. 248 page: 505-510 1998.1
Peptides glycosylated in the eoplasmic reticulum of yeast are subsequently deglycosylated by a soluble peptide N-glycanase activity.
"Suzuki, T., Park, H., Kitajima, K., and Lennarz, W. J.,"
Jorunal of Biological Chemistry Vol. 273 page: 21526-21530 1998.1
"Development of a highly sensitive chemical method to detect α-2,8-linked oligo/polysialic acid residues in glycoproteins blotted on the membrane."
"Sato, C., Inoue, S., Matsuda, T., and Kitajima, K.,"
Anal. Biochemistry Vol. 261 page: 191-197 1998.1
Identification of oligo-N-glycolylneuraminic acid residues in mammal-derived glycoproteins by a newly developed immunochemical reagent a biochemical methods.
"Sato, C., Kitajima, K., Inoue, S., and Inoue, Y.,"
Jounal of Biological Chemistry Vol. 273 page: 2575-2582 1998.1
"Synthesis of neoglycoconjugates containing deaminated neuraminic acid (KDN) using rat liver α2,6-sialyltransferase."
"Angata, T., Matsuda, T., and Kitajima, K.,"
Glycobiology Vol. 8 page: 277-284 1998.1
新しいシアル酸KDNの糖鎖科学の現状と展望
北島健
バイオサイエンスとインダストリー Vol. 56 page: 659-664 1998.1
"Structure and physiological activities of hyosophorin, a major cortical alveolus glycoprotein of fish eggs."
"Kitajima, K., Taniguchi, J., Nakase, M., Kageyama, M., Matsuda, T., Sakagami, H., Inoue, S., and Inoue, Y."
Zygote Vol. 6 page: S6-S7 1998.1
Identification of oligo-N-glycolylneuraminic acid residues mammal-derived glycoproteins by a newly developed immunochemical reagent and biochemical methods.
J. Biol. Chem Vol. 273 page: 2575-2582 1998
Synthesis of neoglycoconjugates containing deaminated neuraminic acid(KDN)using rat liver α2,6-sialytransferase.
Glycobiology Vol. 8 page: 277-284 1998
Peptides glycosylated in the endoplasmic reticulum of yeast are subsequently deglycosylated by a soluble peptide : N-glycanase activity.
J. Biol. Chem. , Vol. 273 page: 21526-21530 1998
Structure and physiological activities of hyosophorin, a major cortical alveolus glycoprotein of fish eggs.
Zygote Vol. 6 page: S6-S7 1998
Induction of KDNase Sm, a deaminoneuraminic acid(KDN)residue-specific sialidase from Sphingobacterium multivorum, using synthetic KDN-glycosides.
Biochem. Biophys. Res. Commun. Vol. 248 page: 505-510 1998
動物細胞におけるデアミノノイラミン酸(KDN)の生合成経路およびKDN複合糖質の発現の調節機構の解析
生化学 Vol. 70 page: 607 1998
Avian egg coat glycoproteins : identification and characterzation of homologues of mammalian zona pellucida glycoproteins.
Zygote Vol. 6 page: S80-S81 1998
Present status and perspectives in research on a novel sialic acid, KDN.
Bioscience and Industry Vol. 56 page: 659-664 1998
Development of an enzyme-linked immunosorbent assay(ELISA)-based method for measuring galactosyltrasferase activity using a synthetic glycopolymer acceptor substrate.
Anal. Biochem. , Vol. 257 page: 169-175 1998
A method for determination of UDP-Glc NAc : GlcNAcβ1-6(GlcNAc(β1-2)Manα1-R[GlcNAc to Man]β 1-4 N-acetylglucosaminyltransferase (]G0006[) activity using a pyridylaminated tetraantennary oligosaccharide as an acceptor substrate.
Anal. Biochem. , Vol. 255 page: 155-157 1998
Cloning and expression of an α2,8-polysialyltransferase(STX)from Xenopus aevis.
Glycobiology Vol. 8 page: 771-777 1998
Development of a highly sensitive chemical method to detect α2→8-linked oligo/polysialic acid residues in glycoproteins blotted on the membrane.
Anal. Biochem. Vol. 261 page: 191-197 1998
Activity of UDP-GlcNAc: GlcNAcβ1-6(GlcNAcβ1-2)Man1-R[GlcNAc to Man]β1-4-N-acetyl glucosaminyl transferase VI(GnT VI) from the ovaries of Oryzias latipes (Medaka fish).
"Taguchi, T., Kitajima, K., Inoue, S., Inoue, Y., Yang, J.-M., Schachter, H., and Brockhausen, I.,"
Biochemical and Biophysical Research Communication Vol. 230 page: 533-536 1997.1
"Occurrence of terminal α2,8-linked disialylated poly-N-acetyllactosamine chains with LeX a I antigenic glycotopes in tetraantennary arms of an N-linked glycoprotein isolated from rainbow trout ovarian fluid."
"Funakoshi, Y., Taguchi, Y., Sato, C., Kitajima, K., Inoue, S., Morris, H. R., Dell, A., and Inoue, Y.,"
Glycobiology Vol. 7 page: 195-205 1997.1
Combined chemical a enzymatic synthesis of a C-glycopeptide a its inhibitory activity toward glycosaminidases.
"Wang, L.-X., Tang, M., Suzuki, T., Kitajima, K., Inoue, Y., Inoue, S., Fan, J.-Q., and Lee, Y. C.,"
Jorunal of American Chemical Society Vol. 119 page: 11137-11146 1997.1
"Catalysis by a new sialidase, deaminoneuraminic acid residue-cleaving enzyme (KDNase Sm), initially forms a less stable α-anomer of 3-deoxy-D-glycero-D-galacto-nononic acid a is strongly inhibited by the transition state analogue, 2-deoxy-2,3-dide hydro-D-glycero-D-galacto-2-nonulosonic acid, but not by 2-deoxy-2,3-didehydro-N-acetylneuraminic acid."
"Terada, T., Kitajima, K., Inoue, S., Wilson, J. C., Norton, A. K., Kong, D. C. M., Thomson, R. J., von Itzstein, M., and Inoue, Y.,"
Jornal of Biological Chemistry Vol. 272 page: 5452-5456 1997.1
KDN:ユニークなシアル酸の世界(Recent Advances in KDN Glycoscience)
北島健
バイオインダストリー Vol. 14 page: 11-21 1997.1
"Proton NMR study of triantennary complex type N-linked glycan chains: assignment of protein chemical shifts of the β-Man residue in a basic unit of the triantennary glycan chain having a GlcNAcβ1,6Manα1,6Manβ1-sequence."
"Taguchi, T., Muto, Y., Kitajima, K., Yokoyama, S., Inoue, S., and Inoue, Y.,"
Glycobiology Vol. 7 page: 31-36 1997.1
Site-sepcific de-N-glycosylation of diglycosylated ovalbumin in hen oviduct by eogenous peptide: N-glycanase as a quality control system for newly synthesized proteins.
"Suzuki, T., Kitajima, K., Emori, Y., Inoue, Y., and Inoue, S.,"
Proc. Natl. Acad. Sci. USA Vol. 94 page: 6244-6249 1997.1
新しいシアル酸KDNの糖鎖生物学の最近の発展(Recent advances in glycobiology on KDN-containing glycoconjugates)
北島健、井上貞子、井上康男
生化学 Vol. 68 page: 44-51 1997.1
Recent advances in glycobiology on KDN-containing alycoconjugates(共著)
Seikagaku Vol. 69 ( 1 ) page: 44-51 1997
糖タンパク質における新しいシアル酸含有糖鎖構造とその機能
日本農芸化学会誌 Vol. 72 page: 452 1997
Catalysis by a new sialidase, deaminoneuraminic acid residue-cleaving enzyme(KDNase Sm), initially forms a less stable α-arromer of KDN and is strongly in kibited by the transition-state analogue, KDN2en, but not Neu5 Ac2en. (共著)
The Journal of Biological Chemistry Vol. 272 ( 9 ) page: 5452-5456 1997
Activity of UDP-GlcNAc : GlcNAcβ1→6(GlcNAcβ1→2)Man α1→R[GlcNAc to Man]β1→4N-acetylglucosaminyl-transferase Vl(GnT Vl)from The ouaries of Oryzias latibes(Medake fish)(共著)
Biochem. Biophys. Res. Commun. Vol. 230 page: 533-536 1997
Proton NMR study of triantennary complex type N-linked glycan chains : assignment of proton chemical shifts of the β-Man residue in a basic unit of the triantennary glycan chain having a GlcNAc β1→6Man α1→6Man β→Sequence(共著)
Glycobiology Vol. 7 ( 1 ) page: 31-36 1997
Site-specific de-N-glycosylation of diglycosylated ovalbumin in hen oviduct byendogenous PNG ase as a quality control systemfor newly synthesized proteins(共著)
Proc. National Academy of Science Vol. 94 page: 6244-6249 1997
Recent advances in KDN glycosciences
Vol. 14 ( 8 ) page: 11-21 1997
"Characterization of the major core structures of the α2,8-linked polysialic acid-containing glycan chains present in neural cell adhesion molecule (N-CAM) in embryonic chick brains."
"Kudo, M., Kitajima, K., Inoue, S., Shiokawa, K., Morris, H. R., Dell, A., and Inoue, Y.,"
Jorunal of Biological Chemistry Vol. 271 page: 326667-32677 1996.1
"Occurrence of poly α2,8 deaminoneuraminic acid (KDN) in mammalian tissues: Widespread a developmentally-regulated but highly selective expression on glycoproteins."
"Ziak, M., Qu, B., Zuo, X., Zuber, C., Kanamori, A., Kitajima, K., Inoue, S., Inoue, Y., and Roth, J.,"
Proc. Natl. Acad. Sci. U.S.A. Vol. 93 page: 2759-2763 1996.1
"Iuction, localization, a purification of a novel sialidase, deaminoneuraminidase (KDNase), from Sphingobacterium multivorum."
"Nishino, S., Kuroyanagi, H., Terada, T., Inoue, S., Inoue, Y., Troy, F. A., II, and Kitajima, K.,"
Journal of Biological Chemistry Vol. 271 page: 2909-2913 1996.1
"The occurrence of novel 9-O-sulfated N-glycolylneuraminic acid-cappedα2,5-Oglycolyl-linked oligo/polyNeu5Gc chains in sea urchin egg cell surface glycoprotein. Identification of a new chain termination signal for polysialyltransferase."
"Kitazume, S., Kitajima, K., Inoue, S., Haslam, S. M., Morris, H. R., Dell, A., Lennarz, W. J., and Inoue, Y.,"
Jornal of Biological Chemistry Vol. 271 page: 6694-6701 1996.1
Occurrence a precise structural analysis of highly sulfated multiantennary N-linked glycan chains derived from a fertilization-associated carbohydrate-rich glycoprotein in unfertilized eggs of Tribolodon hakonensis.
"Taguchi, T., Iwasaki, M., Muto, Y., Kitajima, K., Inoue, S., Khoo, K.-H., Morris, H. R., Dell, A., and Inoue, Y.,"
European Jornal of Biochemistry Vol. 238 page: 357-367 1996.1
Isolation a identification of novel sulfated a nonsulfated oligosialyl glycosphingolipids from sea urchin sperm.
"Ijuin, T., Kitajima, K., Yu, S., Kitazume, S., Inoue, A., Haslam, S. M., Morris, H. R., Dell, A., and Inoue, Y.,"
Glycoconjugate Journal Vol. 13 page: 401-413 1996.1
Structure and function of N-glycosylated glycoprotein in fish eggs and embryos.
"Kitajima, K."
Nippon Suisan Gakkaishi Vol. 62 page: 289-290 1996.1
Substrate specificity of rainbow trout testis CMP-KDN synthetase. Kinetic studies of the CMP-KDN synthetase-catalyzed reaction of natural a synthetic analogues of nonulosonic acid.
"Terada, T., Kitajima, K., Inoue, S., Koppert, K., Brossmer, R., and Inoue, R.,"
European Journal of Biochemistry Vol. 236 page: 852-855 1996.1
"Identification of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN, deaminoneuraminic acid) residues in mammalian tissues a human lung carcinoma cells. Chemical evidence of the occurrence of KDN glycoconjugates in mammals."
"Inoue, S., Kitajima, K., and Inoue, Y.,"
Journal of Biological Chemistry Vol. 271 page: 24341-24344 1996.1
Identification of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid(KDN, deaminoneuraminic acid)residues in mammalian tissues and human lung carcinoma cells. (共著)
The Journal of Biological Chemistry Vol. 271 ( 40 ) page: 24341-24344 1996
Induction, localization, and purification of a novel sialidase, deaminoneuraminidase (KDNase), from Sphingobocteriun multivorum.
The Journal of Biological chemistry Vol. 271 ( 6 ) page: 2909-2913 1996
Structure and function of N-glycosylatecl glycoprotein in fish eggs and embryos.
Nippon Suisan Gakkaishi Vol. 62 ( 2 ) page: 289-290 1996
The occurrence of novel 9-O-Sulfated N-glycolylneuraminic acid-capped α2→5-Oglycolyl-limked oligo/poly Neu5Gc chains in Sea urchin egg cell surface glycoprotein. Identification of a new chain termination signal for polysialyltransferse.(共著)
The Journal of Biological Chemistry Vol. 271 ( 12 ) page: 6694-6701 1996
Characterization of the major core structures of the α2→8-linked polysialic acid-containing glycan chains present in neural cell adhesion molecule in embryonic chick brains. (共著)
The Journal of Biological Chemistry Vol. 271 ( 51 ) page: 32667-32677 1996
Isolation and identification of novel sulfated and nonsulfated oligosialyl glycosphingolipids from sea urchin sperm.
Glycoconjugate Journal Vol. 13 ( 3 ) page: 401-413 1996
Substrate specificity of rainbow trout testis CMP-3-deoxy-D-glycero-D-galaeto-noncelosonic acicl (CMP-Kdn) synthe tase. Kinetic studies of the reaction of natural and synthetic analogues of ncnulosonic acid catalyzed by CMP-Kdn syuthefase.(共著)
European Journal of Biochemistry Vol. 236 page: 852-855 1996
Occurrence of poly(α2,8-deamino neuraminic acid) in mammalian tissues: widespread and developmentally regulated but highly selective expression on glycoprotoins.(共著)
Proclaim of National Academy of Science, U.S.A. Vol. 93 page: 2759-2763 1996
Occurrence and structural analysis of highly sulfated multiantennary N-lmked glycan chains derived from a fertilization-associated carbohydrate-rich glycoprotein in unfertilized eggs of Tribolodon hakonensis. (共著)
European Journal of Biochemistry Vol. 238 page: 357-367 1996
Expression of new KDN-gangliosides in rainbow trout testis during spermatogenesis a their structural identification.
"Yu, S., Kitajima, K., Inoue, S., Khoo, K.-H., Morris, H. R., Dell, A., and Inoue, Y.,"
Glycobiology Vol. 5 page: 207-218 1995.1
Complete assignment of carbon-13 NMR resonances to all the carbon atoms of the trimannosido-di-N-acetylchitobiosyl structure in a pentaantennary decasaccharide glycopeptide.
"Taguchi, T., Kitajima, K., Niimi, T., Muto, Y., Yokoyama, S., Inoue, S., and Inoue, Y.,"
Carbohydr. Res. Vol. 275 page: 185-191 1995.1
A precise structural analysis of a fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of euryhaline killi fish (Fuulus heteroclitus). Novel pentaantennary N-glycan chains with a bisecting N-acetylglucosaminyl residue.
"Taguchi, T., Kitajima, K., Muto, T., Inoue, S., Khoo, K.-H., Morris, H. R., Dell, A., Wallace, R. A., Selman, K., and Inoue, Y.,"
Glycobiology Vol. 5 page: 611-624 1995.1
N-Glycosylation/deglycosylation as a mechanism for the post-translational modification/remodification of proteins.
"Suzuki, T., Kitajima, K., Inoue, S., and Inoue, Y.,"
Glycoconjugate Journal Vol. 12 page: 183-193 1995.1
Proton NMR study of the trimannosyl unit in a pentaantennary N-linked decasaccharide structure. Complete assignment of the proton resonances a conformational characterization.
"Taguchi, T., Kitajima, K., Muto, Y., Yokoyama, S., Inoue, S., and Inoue, Y.,"
European Jornal of Biochemistry Vol. 288 page: 822-829 1995.1
"Characterization of the antigenic specificity of four different anti-(α2,8-linked polysialic acid) antibodies using lipid-conjugated oligo/polysialic acids."
"Sato, C., Kitajima, K., Inoue, S., Seki, T., Troy, F. A., II, and Inoue, Y.,"
Journal of Biological Chemistry Vol. 270 page: 18923-18928 1995.1
Identification a distribution of peptide: N-glycanase (PNGase) in mouse organ.
"Kitajima, K., Suzuki, T., Kouchi, Z., Inoue, S., and Inoue, Y.,"
Arch. Biochem. Biophys. Vol. 319 page: 393-401 1995.1
Carbohydrate-biing property of peptide: N-glycanase (PNGase) from mouse fibroblast L-929 cells as evaluated by inhibition a biing experiments using various oligosaccharides.
"Suzuki, T., Kitajima, K., Inoue, S., and Inoue, Y.,"
Journal of Biological Chemistry Vol. 270 page: 15181-15186 1995.1
A precise structural analysis of a fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of euryhaline killi fish (Fundulus heteroclitus). Novel qenta-antennary N-glycar chains coith a bisecting N-acetylqlucosampyl residel,
Glycobiology Vol. 5 ( 6 ) page: 611-624 1995
Proton NMR study of the triomannosyl unit in a pentaanternary N-linked decasaccharide structure (共著)
European Journal of Biochemistry Vol. 228 page: 822-829 1995
Complete assignments of BC NMR resonance to all the carbon atoms of the trimannosido-di-N-acetylchitobiosyl structure in a pentaantennary decusaccharide glycopepticle.(共著)
Carbohyclrate Researoh Vol. 275 page: 185-191 1995
I dentification and distribution of peptide: N-glycanase (PNGose) in mouse organs.
Archives of Biochemistry and Bioplcysics Vol. 319 ( 2 ) page: 393-401 1995
Carbohydrate-binding property of peptide: N-glyecanase from mouse fibroblast L-929 cells as evaluated by inhibition and binding experiments using various oligosaccharides.
The Journal of Biological Chemistry Vol. 270 ( 25 ) page: 15181-15186 1995
Characterization of the antigenic specificity of four different anti(α2→8-linked polysialit acid) antibodies using lipid- conjugated oligo/polysialic acids.(共著)
The Journal of Biologicol chemistry Vol. 270 ( 32 ) page: 18923-18928 1995
N-Glycosylation/deglycosylation as a mechanism for the post-translational modification/remodification of proteins(共著)
Glycoconjugate Journal Vol. 12 ( 1 ) page: 183-193 1995
Expression of new KDN-gangliosides in rainbow trout testis during spermatogenesis and their structural identification (共著)
Glycobiology Vol. 5 ( 2 ) page: 207-218 1995
Discovery of a New type of sialidase, "KDN ase, " which specifically hydrolyzes deamironeuraminyl (3-deoxy-D-glycero-D-galacto-2-nonulosonic acid) but not N-acylneuraminyl linkages
The Journal of Biological Chemistry Vol. 269 ( 34 ) page: 21415-21419 1994
Occurrence and biological roles of 'proximal glycanases' in animal cells (共著)
Glycobiology Vol. 4 ( 6 ) page: 777-789 1994
Calcium ion binding of three different types of oligo/polysialic acids as studied by equilibrium dialysis and circular dichroic methods (共著)
Biochemistry Vol. 33 ( 5 ) page: 1202-1208 1994
Differential reactivity of two types of N-ghycolylneuraminic acid dimers toward enzymatic and nonenzymatic hydrolysis of their interketosidic linkages (共著)
Biochemical and Biophysical Research Communication Vol. 205 ( 1 ) page: 893-898 1994
Identification, characterization, and developmental Expression of a novel α2→8-KDN-transferase which terminates elongation of α2→8-linked oligo-polgsialic acid chain synthesis in trout egg polysialoglycoproteins (共著)
Glycoconjugate Journal Vol. 11 page: 493-499 1994
Does an animal peptide : N-glycanase have the dual role as an enzyme and a carbohydrate-binding protein ? (共著)
Glycoconjugate Journal Vol. 11 page: 469-476 1994
Purification and enzymatic properties of peptide : N-glycanase from C3H mouse-derived L-929 fibroblast cells. (共著)
The Journal of Biological Chemistry Vol. 269 ( 26 ) page: 17611-17618 1994
Isolation, structural determination, and calcium-binding properties of the major glycoprotein present in Bufo Japouicus japonicus egg jelly (共著)
European Journal of Biochemistry Vol. 223 page: 223-231 1994
Identification of polysialic acids in glycoconjugates (共著)
Methods in Enzymology Vol. 230 page: 460-484 1994
Identification, developmental expression and tissue distribution of deaminonouraminate hydrolase (KDNase) activity in rainbow trout (共著)
Glycobiology Vol. 4 ( 4 ) page: 517-523 1994
Developmental Expression of trout egg poly sialogly coproteis and the preroquisite α2,6-, and α2,8-sialyl and α2,8-poly-sialyltransferase activities required for their synthesis during oogenesis (共著)
The Journal of Biological Chemistry Vol. 269 ( 14 ) page: 10330-10340 1994
Identification and structural determination of the KDN-containing N-linked glycan chains consisting of bi-and tri-dntennary complex-type units of KDN-glycoprotin previously isolated from rainbow trout vitelline envelopes (共著)
Biochemistry Vol. 33 ( 21 ) page: 6495-6502 1994
Identification of polysialic acid-containing glyroprotein in the jelly coat of sea urchin eggs. (共著)
The Journal of Biological Chuistry Vol. 269 ( 36 ) page: 22712-22718 1994
Structural studies of a novel type of penta artennary large glycan unit in the fertilization-associated carbohydraterich glycopeptide isolated from the fertilized eggs of Oryzias latipes (共著)
The Journal of Biological Chemistry Vol. 269 ( 12 ) page: 8762-8771 1994
Monoclonal antibody speatic for α2→8-linked olrgo dominated neuraminic acid (KDN) sequeuces in glycoproteins. Preparation and characterization of a manoclonal antibody and its application in immunohistochemistry (共著)
Histochemistry Vol. 101 ( 5 ) page: 333-340 1994
CMP-3-Deoxynonulosonate Synthetase which Catalyzes the Transfer of CMP to KDN from CTP : Partial Purification and Characterization of the Enzyme from Rainbow trout testis. (共著)
Polysiolic Acid, Birkh(]J1103[)user-Verlag Basel, Switzerland page: 191-199 1993
Immunochemical Method as Early Diagnosis for Distinguishing Salmonid Fish Female and Male Prior to Genital Maturation by use of a Minute Amount of Blood Collected from a Single Piece of Gill Filament (共著)
Nippon Suisan Gakkaishi Vol. 59 ( 4 ) page: 593-600 1993
Monoclonal Antibody Specific to α-2→3-Linked Deaminated Neuraminyl β-Galactosyl Sequence (共著)
Glycobiology Vol. 3 page: 31-36 1993
Synthesis of CMP-Deaminoneuraminic Acid (CMP-KDN) Usig the CTP : CMP-3-Deoxynonulosonate Cytidylyl-transferase from rainbow trout testis. (共著)
The Journal of Biological Chemistry Vol. 268 page: 2640-2648 1993
Analytical methods for identifying and quantitating poly (α2→8 Sia) structures containing Neu5Ac, Neu5Gc, and KDN.(共著)
Polysialic acid, Birkh〓user-Verlag, Basel, 5witzerland page: 183-189 1993
Structure studies of a novel type of tetraantennary sialoglycan unit in a carbohydrate-rich glycopeptide isolated from the fertilized eggs of Indian medaka fish, Oryzias melastigma (共著)
The Journal of Biological Chemistry Vol. 268 page: 2353-2362 1993
Identification of peptide : N-glycanase activity in mammalian-derived cultured cells (共著)
Biochemical and Biophysical Research Communication Vol. 194 ( 3 ) page: 1124-1130 1993
Structural diversity in the α2→8-linked polysiolic acid chains in Solmonid fish egg glycoproteins. (共著)
The Journal Biological Chemistry Vol. 268 page: 23675-23684 1993
Structure of novel gangliosides, deaminated neurominic acid (KDN)-containing glycosphingolipids, isolated from rainbow trout ovarian fluid (共著)
Biochemistry ( 32 ) page: 9221-9229 1993
Analytical Methods for Identifying and Quantitating Deamidated Sialic Acid and α2→8-Linked Poly(Oligo)nonulosonate Residues in Glycoconjugates
Analytical Biochemistry Vol. 205 page: 244-250 1992
KDN : A novel scelit acid analogue
Protein, nucleic acid and enzyme Vol. 37 ( 11 ) page: 1976-1981 1992
Detection, isolation, and characterization of oligo/poly(sialic acid) and oligo/poly (deamino-niuraminic acid) units in glycoconjugates (共著)
Analytical Biochemistry Vol. 202 page: 25-34 1992
Fish egg glycophosphoproteins have species-specific N-linked glycan units previously found in a storage pool of free glycan chains (共著)
The Journal of Biological Chemistry Vol. 267 ( 34 ) page: 24287-24296 1992
Peptide : N-glycanase activity found in the early embryos of Oryzias latipes (Medaka fish) (共著)
The Journal of Biological Chemistry Vol. 266 ( 33 ) page: 22110-22114 1991
Isolation and structural elucidation of a novel type of ganglioside, deaminated neuraminic acid (KDN)-containing glycosphingolipid, from rainbow trout sperm. The first example of the natural occurrence of KDN-ganglioside, (KDN)GM3.(共著)
The Journal of Biological Chemistry Vol. 266 ( 22 ) page: 21929-21935 1991
Identification of rainbow traet of delayed maturity(3-yera-maturation) based on cortical alveolar glycopooteins (hyosophorin).
Nippon Suisan Gakkaishi Vol. 57 ( 7 ) page: 1355-1364 1991
Identification of free glycan chain liberated by de-N-glycosylation of the cortical alveolar glycoprotein (hyosophorin) during early embryogenesis of the medaka fish, Oryzias latipes.(共著)
Biochemical and Biophysical Research Communication Vol. 180 ( 3 ) page: 1165-1171 1991
Structure and Biological Function of Cortical Alveolus Glycoprotein(hyosophorin)
Vol. 7 ( 3 ) page: 125-132 1990
New tandem-repeating peptide structures in pulysialo-ghycoproteins from the unfertilized eggs of kokanee salmon.(共著)
Archives of Biochemistry and Biophysics Vol. 283 ( 1 ) page: 167-172 1990
Deaminated neuraminic acid-rich glycoprotein of rainbow trout egg vitelline envelope. Occurrence of a novel α-2,8-linked oligo(deaminated neuraminic acid) structure in O-linked glycan chains.(共著)
The Journal of Biological chemistry Vol. 265 ( 35 ) page: 21811-21819 1990
Isolation and structures of glycoprotein-derived free sialooligosaccharide from the unfertilized eggs of Tribolodon hakonensis, a dace. Intracellular accumulation of a novel class of biantennary disialooligosaccharides.(共著)
The Journal of Biological Chemistry Vol. 264 page: 18520-18526 1989
Structural Studies of Fertilization-associated Carbohydrate-rich Glycoproteins(Hyosophorin) Isolated from the Fertilized and Unfertilized Eggs of Flounder, Parolichthys olivaceus.
The Journal of Biological Chemistry Vol. 264 ( 27 ) page: 15922-15929 1989
Isolation and Characterization of a Novel Type of Sialoglycoproteins(Hyosophorin)from the Egg of Medaka, Oryzias latipes : Nonapeptide with a Large N-Linked Glycan Chainasa Tandem Repeat Unit
Developmental Biology Vol. 132 page: 544-553 1989
Isolation and characterization of cleaminated neuraminic acid-rich glycoprotein (KDN-gp-OF) in the ovarian fluid of rainbow trout.(共著)
Biochemical and Birophysical Research Communication Vol. 164 page: 1744-1749 1989
Mitogenic activity of pine cone extracts against cultured splenocyta from normal and tumor-bearing animals.(共著)
Anticancer Research Vol. 9 page: 961-966 1989
Inhibition of herpes simplex virus infection by tannins and related compounds.(共著)
Antiviral Research Vol. 11 page: 285-298 1989
Molecular Cloning and Characterization of cDNAs Coding for Apo-Polysialoglycoprotein of Rainbow trout Eggs.
The Journal of Biological Chemistry Vol. 263 ( 33 ) page: 17678-17684 1988
A Proteinase Associated with Cortices of Rainbow Trout Eggs and Involved in Fertilization-Induced Depolymerlzation of Polysialoglycoproteins
Developmental Biology Vol. 129 page: 270-274 1988
Use of a Bacteriophage-derived Endo-N-acetylneuraminidase and an Equine Antipolysialyl Antibody to characterize the Polysialyl Residues in Salmonid Fish Egg Polysialoglycoproteins.
The Journal of Biological Chemistry Vol. 263 ( 34 ) page: 18269-18276 1988
comparative Structures of the Apopolysialoglycoproteins from Unfertilized and Fertilized Eggs of Salmonid Fishes
Biochemistry Vol. 27 page: 7141-7145 1988
KDN-glycoprotein: A novel deaminated neuraminic acid-rich glycoprotein isolated from vitelline envelope of rainbow trout eggs.(共著)
Biochemical and Biophysical Research Communication Vol. 153 page: 172-176 1988
Localization of polysialoglycoprotein as a major glycoprotein component in cortical alveoli of the unfertilized eggs of Salmo gairclneri.(共著)
Developmental Biology Vol. 123 page: 442-454 1987
A naturally occurring deaminated neuraminic aced, 3-deoxy-D-glycero-D-galacto-nonulosonic acid (KDN). Its unique occurrence of the nonredueing encls of oligosialyl chains in polysialoglycoprotein of rainbow trout eggs.(共著)
The Journal of Biological chemistry Vol. 261 page: 11550-11557 1986
Polysialoglycoproteins of Salmonidae Fish Eggs. Complete structure of 200-kDa polysialoglycoprotein from the unfertilizaed eggs of rainbow trout.
The Journal of Biological Chemistry Vol. 261 ( 12 ) page: 5262-5269 1986
A mechanistic consideration of the hydrazinolysis of 3-O-substituted, 2-acetgmido-2-deoxy-D-hexopyranosyl and-D-hexitol residues in the absence and presence of hydroziniun sulfate.(共著)
Carbhyolrate Research Vol. 135 page: 342-347 1985
Fish Egg Polysialoglycoproteins : Circular Dichroism and Proton Nuclear Magnetic Resonance Studies of Novel Oligosaccharide Units Containing One Sialidase-Resistant N-Glycolylneuraminic Acid Residuein Each Molecule
Biochemistry Vol. 23 page: 305-309 1984
Novel oligosaccharide chains on polysialog lycoproteins isolated from rainbow trout eggs.(共著)
Biochemistry Vol. 23 page: 305-310 1984
Isolation and structures of the third mceJor type of carbohydrate units in polysialoglycoproteins from rainbow trout eggs.(共著)
Biochemistry International Vol. 8 page: 573-579 1984
Biological roles of glycan chains Reviewed
( Role: Joint editor)
2020.2 ( ISBN:978-4-8158-0981-2 )
Glycome: The Hidden Code in Biology Reviewed
Chihiro Sato, Ken Kitajima( Role: Contributor , Chapter 5. Polysialic Acid as an Integrative Decoder in Nervous and Reproductive Systems)
nova science publisher 2021.5 ( ISBN:978-1-53619-377-0 )
Role of polysialic acid in schizophrenia Reviewed
Sato C., Hane M, Kitajima, K( Role: Joint author)
Elsevier 2020
未来を創るグライコサイエンス:我が国のロードマップ Reviewed
北島健( Role: Joint author , 3-44 遺伝子改変:小型魚類 (3))
日本糖鎖科学コンソーシアム、エム ディー オー 2018
Hsp70の酸性複合糖質結合活性の発見. 糖の意外な働き
原田陽一郎、佐藤ちひろ、北島健( Role: Joint author)
国際文献社 2017
第2章糖鎖と生命 第1節 受精
北島健( Role: Sole author)
エヌ・ティー・エス 2015
Chihiro Sato, Ken Kitajima ( Role: Joint author)
Springer 2015
Masaya Hane, Ken Kitajima, Chihiro Sato( Role: Joint author)
Springer 2015
Kanazawa T**, Suzuki E*, Miyata S, Sato C, and Kitajima K.( Role: Joint author)
Springer 2015
Enzyme assay of polysialyltransferase
Kitajima K, Sato C. ( Role: Joint author)
JCGGDB 2014
Advanced technologies in sialic acid and sialoglycoconjugate analysis
Ken Kitajima, Nissi Varki, and Chihiro Sato.( Role: Joint author)
Springer 2013
N-acetylneuraminic acid 9-phosphatase (NANP)
Ken Kitajima( Role: Sole author)
Springer 2013
Biological problems, methods, and applications (The roles of carbohydrate binding in cell adhesion and inflammation.)
Kitajima, K. and Sato, C.( Role: Joint author)
John Wiley and Sons 2011
Analysis of glycan-protein interaction by frontal affinity chromatofraphy and Biacore in Methods in Enzymology (Minoru Fukuda ed. in glycomics)
Sato C., Kitajima, K. and Sato, C.( Role: Joint author)
Elsevir science 2010
生物学辞典
北島健( Role: Joint author)
東京化学同人 2010
18. Enzyme assay of polysialyltransferase. in Glycoscience Protocol Online
Ken KItajima( Role: Joint author)
JCGG-DG 2010
Glycoscience Lab Manual (Membrane microdomain as a platform of carbohydrate-mediated interaction during early development of medaka fish.)
Adachi, T., Sato, C., and Kitajima, K.( Role: Joint author)
Springer 2008
Glycoscience Lab Manual (Structural analysis of polysialic acid)
Sato, C., and Kitajima, K.( Role: Joint author)
Springer 2008
実験医学・受精における糖鎖の役割
北島健( Role: Sole author)
羊土社 2007
細胞工学・シアル酸の構造多様性とその生物学的意義
北島健、郷慎司、藤田明子、佐藤ちひろ( Role: Joint author)
秀潤社 2007
新編精子学・精子表面の糖脂質の役割
北島健( Role: Sole author)
東京大学出版会 2006
未来を拓く糖鎖科学・メダカ初期胚における糖鎖に富む生体膜マイクロドメインの役割
北島健( Role: Sole author)
金芳堂 2005
未来を拓く糖鎖科学・ポリシアル酸の構造解析
北島健( Role: Joint author)
金芳堂 2005
遺伝子医学MOOK 3 糖鎖と病気・4)ポリシアル酸. 5糖鎖と発生
佐藤ちひろ、北島健( Role: Joint author)
メディカルドゥ 2005
生化学実験講座
北島健( 編:日本生化学会編)( Role: Joint author)
東京化学同人 2000
KDN:デアミノノイラミン酸
日本生化学会編 基礎生化学実験法、東京化学同人 2000
Occurrence of alpha-2,8-linked oligosialic acid residues in mammalian glycoproteins.
Sialobiology and Other novel Form of Glycosylation, a monograph (Inoue, Y., Lee, Y. C., and Troy, F. A., eds) Gakushin Syuppan, Osaka, Japan 1999
細胞機能と代謝マップ
"安形高志,北島健,井上康男( 編:日本生化学会)"( Role: Joint author)
東京化学同人 1997
生体物質の化学(共著)
大日本図書 1996
新化学ライブラリー
北島健、井上康男( 編:日本化学会)( Role: Joint author)
大日本図書 1996
KDN-ganglioside
Guide to techniques in Ganglioside Research 1995
生物化学実験法シリーズ:ガングリオシド研究法
"北島健,井上貞子( 編:鈴木康夫,安藤進)"( Role: Joint author)
学会出版センター 1995
ポリシアル酸 (共著)
講談社グリコバイオロジーシリーズ 1993
糖鎖の流儀:不均一性と場の形成 Invited
北島健
第17回 糖鎖科学コンソーシアムシンポジウム 2019.10.29 日本糖鎖科学コンソーシアム
Comparative studies of the insect and vertebrate sialate 9-phosphate synthase (SPS) Invited International conference
Ken Kitajima
Sialoglyco 2018 Sialoglyco Organizing Committee
巨大糖脂質:糖鎖に富むGPI-アンカーペプチドの進化と生理機能
北島 健
第7回「ナノカーボンバイオセンサーの医療応用研究会」
Elusive Localization of the Insect CMP-sialic Acid Synthetases Invited International conference
Ken Kitajima
Glycoscience Japan- The Netherlands Joint Seminar 2016
Why does sialic acid deficiency cause the embryonic lethality in medaka fish, Oryzias latipes? Invited International conference
Ken Kitajima
Glycoscience Japan- The Netherlands Joint Seminar 2016
Glycan-mediated Interactions on Pig Sperm Lipid Rafts during Fertilization. Invited International conference
Ken Kitajima
Proceedings of the APMC11 / MST33 / AAT39 Conference
曖昧な生体分子:糖鎖の生体機能を探る
北島 健
第7回「ナノカーボンバイオセンサーの医療応用研究会」
精子膜マイクロドメイン局在糖鎖の受精における役割
北島健
第13回日本糖鎖科学コンソーシアムシンポジウム
Functional significance of glycan-mediated interactions on sperm microdomains during fertilization International conference
Ken Kitajima
23rd International Symposium on Glycoconjugates (Glyco23)
Effects of psychiatric disorders-related intronic single nucleotide polymorphisms (iSNPs) of the polysialyltransferase ST8SIA2/STX gene. International conference
Masaya Hane, Ken Kitajima, Chihiro Sato
23rd International Symposium on Glycoconjugates (Glyco23)
Analysis of a ligand-binding mechanism among sialic-acid binding sites in Siglec-7. International conference
Di Wu, Akiko Fujita, Yuko Yasukawa, Yoshihito Taniguchi, Yasuhiro Kamei, Chihiro Sato, Ken Kitajima.
23rd International Symposium on Glycoconjugates (Glyco23)
Catabolism of sialic acid residues during pre-hatching development. International conference
Bo Fu, Di Wu, Chihiro Sato, Ken Kitajima
23rd International Symposium on Glycoconjugates (Glyco23)
Comparative characterization of the insect CMP-sialic acid synthetases in the enzyme activity and intracellular localization.
Di Wu, Akiko Fujita, Anne Harduin-Lepers, Philippe Delannoy, Vladislav M. Panin, Chihiro Sato, and Ken Kitajima.
4th Austria/Japan seminar on comparative and developmental glycobiology
Mining of marine invertebrate glycoconjugates with anti-microbial activity. Invited International conference
Ken Kitajima, Yann Guérardel
Bio-Asia 2015 Annual Conference
A polysialyltransferase SNP in a schizophrenic patient brings about the production of polysialic acids showing impaired binding and signaling of BDNF and FGF2. International conference
8th International Symposium on Glycosyltransferases
New features on biosynthesis and degradation of free sialic acids. International conference
Kiel University Department of Chamistry Seminar
Sia usage: How does the cell express particular sialic acid species? International conference
Sialoglyco 2010, August, 21-26, 2010; Potsdam, Germany
Discovery of a 16-30-kDa, highly glycosylated glycoprotein from pig seminal plasma (WGA16) that regulates sperm fertilizability. International conference
25th International Carbohydrate Symposium (ICS2010) Makuhari Messe International Convention Complex; Tokyo(Chiba), Japan
ラット海馬におけるシアル酸分子種含有糖鎖の発現.
日本薬学会第130年会
細胞外シアル酸およびその前駆体のシアル酸生合成への効果
日本農芸化学会2010年度大会.
グリコサミノグリカン鎖と脳由来神経栄養因子の相互作用の解析.
日本農芸化学会2010年度大会.
ブタ精子細胞膜マイクロドメイン局在糖タンパク質の受精における機能
日本農芸化学会2010年度大会.
CMP-シアル酸合成酵素のCMP-KDN合成能の構造的基盤.
日本農芸化学会2010年度大会.
シグレック-7のオリゴシアル酸結合能および新規シアル酸結合ドメインの存在証明.
CREST糖鎖最終シンポジウム.
ポリシアル酸と統合失調症.
第7回糖鎖科学コンソーシアムシンポジウム-糖鎖研究と他領域との統合[グライコケミカルバイオロジーとグライコテクノロジーへの展開]
Molecular mechanism for differential recognition of the C-5 substituents of sialic acid by CMP-sialic acid synthetases: Identification of the evolutionally conserved sialic acid recognition region. International conference
20th International Symposium on Glycoconjugate (GlycoXX 2009); Nov 29-Dec 4, 2009; San Juan, Puerto Rico
A new function of polysialic acid on NCAM as the reservoir for the particular groups of neurotrophins, growth factors, and neurotransmitters that regulate the neural activity. International conference
20th International Symposium on Glycoconjugate (GlycoXX 2009); Nov 29-Dec 4, 2009; San Juan, Puerto Rico
In silico and in vitro binding studies predict a novel sialic acid binding site on the sialic acid binding Ig-like lectin-7 (Siglec-7). International conference
20th International Symposium on Glycoconjugate (GlycoXX 2009); Nov 29-Dec 4, 2009; San Juan, Puerto Rico
Membrane Microdomains as a Platform of Carbohydrate-mediated Cell-cell Interactions during Gastrulation. International conference
4th 2009 Annual Meeting of Koren Society of Glycoscience, 2009 KSG International Glycoscience Symposium; Dajeon, Korea
シアル酸結合免疫グロブリン様レクチン(シグレック)-7によるシアロ糖鎖認識の生化学的および分子ドッキング解析.
第47回日本生物物理学会年会.
魚類CMP-シアル酸合成酵素の構造とシアル酸分子種認識.
第82回日本生化学会大会.
CMP-シアル酸合成酵素のシアル酸分子種認識および核局在決定領域の生物種間比較.
第82回日本生化学会大会.
ポリシアル酸転移酵素の一塩基多型変異体の酵素活性と統合失調症との関連.
第82回日本生化学会大会.
分子ドッキングおよび生化学的結合解析によるシグレック-7の糖鎖認識の構造学的知見.
第82回日本生化学会大会.
マウス新生仔脳局在A2B5エピトープ含有糖タンパク質のシアロ糖鎖の特徴と生合成
第82回日本生化学会大会.
NCAMを修飾するポリシアル酸鎖とFGF-2の相互作用解析.
第82回日本生化学会大会.
Siglec-7のオリゴシアル酸結合能の解析と新規シアル酸結合ドメインの存在検証.
第82回日本生化学会大会.
マウス脳発達段階におけるA2B5エピトープ含有糖タンパク質の発現と解析.
糖鎖科学名古屋拠点[若手の力]フォーラム第7回.
ブタ精子膜マイクロドメインに局在する糖タンパク質の役割解明.
糖鎖科学名古屋拠点[若手の力]フォーラム第7回.
メダカ初期胚生体膜マイクロドメインに局在する巨大糖タンパク質の発現解析と精製・性質.
糖鎖科学名古屋拠点[若手の力]フォーラム第7回.
ウニの受精・発生過程における2E8糖鎖エピトープの発現と機能解析.
糖鎖科学名古屋拠点[若手の力]フォーラム第7回.
メダカ初期胚生体膜マイクロドメイン局在メガ糖タンパク質の発現解析と精製.
日本動物学会第80回大会.
ウニの受精および初期発生における2E8糖鎖抗原の発現変化.
日本動物学会第80回大会.
ブタ精子細胞膜マイクロドメイン局在糖タンパク質の同定と受精能獲得における変化.
日本動物学会第80回大会.
分子ドッキングおよび生化学的結合解析によるシグレック-7の糖鎖認識の構造学的知見.
第29回日本糖質学会年会
魚類CMP-シアル酸合成酵素の構造とシアル酸分子種認識.
第29回日本糖質学会年会
ウニの受精・発生過程における2E8糖鎖エピトープの発現と機能解析
第29回日本糖質学会年会
NCAMを修飾するポリシアル酸鎖とFGF-2の相互作用解析.
第29回日本糖質学会年会
メダカ初期胚生体膜マイクロドメインに局在する巨大糖タンパク質の発現解析と精製
第29回日本糖質学会年会
Siglec-7のオリゴシアル酸結合能の解析と新規シアル酸結合ドメインの存在検証.
第29回日本糖質学会年会
マウス脳発達段階特異的に発現するA2B5エピトープ含有糖タンパク質の糖鎖解析.
第29回日本糖質学会年会
統合失調症に関わるポリシアル酸転移酵素変異体の活性解析.
第29回日本糖質学会年会
CMP-シアル酸合成酵素の基質認識および細胞内局在決定領域の生物種間比較.
第29回日本糖質学会年会
Glycosaminoglycan-dependent complex formation of 70-kDa heat shock protein.
第29回日本糖質学会年会
ブタ精子マイクロドメインに局在し多分散性を示す糖タンパク質の同定.
第29回日本糖質学会年会
CMP-シアル酸合成酵素の進化とシアル酸認識機構の相関.
FCCAグライコサイエンス若手フォーラム.
ポリシアル酸と線維芽細胞増殖因子との相互作用解析.
FCCAグライコサイエンス若手フォーラム.
分子モデリング法による熱ショックタンパク質(Hsp70)の酸性糖脂質結合性の解析.
名古屋大学若手女性研究者サイエンスフォーラム.
オリゴシアル酸とSiglec-7との相互作用解析.
第73回日本生化学会中部支部例会.
Novel aspects of substrate specificity and nuclear localization of CMP-sialic acid synthetases as revealed by studies of fish enzymes.
ORI Seminar; April 27, 2009; Ocean Research Institute, University of Tokyo, Tokyo
Polysialic acid is not a negative regulator any longer in neurogenesis and neuronal functions: A new finding of its binding to a particular group of neurotransmitters. International conference
Gordon Research Conference on Glycobiology
Membrane microdomains as a plarform of carbohydrate- and protein-mediated cell-cell interaction in fertilization and early development International conference
Biochemistry and Molecular Biology
A one-day symposium on Sialyltransferases, Functional Glycomics, and Genomics of Zebrafish International conference
Functional Glycomics, and Genomics of Zebrafish
Membrane microdomains from early gastrula embryos of medaka are a platform of E-cadherin- and LeX-mediated cell-cell interactions during epiboly International conference
14th Japanese Medaka and Zebrafish Meeting
Occurrence of the Cyclic Sialic Acid in Mammalian Cells and Tissues As Demonstrated by Chemical Methods.
24th International Carbohydrate Symposium
Significance of the existence of deaminoneuraminic acid (KDN) in mammalian cells in Its metabolic and functional features. International conference
SialoGlyco Conference 2008
シアロメタボロームから見た生命科学シンポジウム「次世代の糖鎖科学」
北島 健
日本農芸化学会2008年度大会
ウニ精子表面シアロ糖鎖の受精における役割
北島健
日本動物学会第78回大会 シンポジウム「受精シンポジウム:温故知新による受精研究ネクストステージの幕開け-2部-」(2007年9月20-23日; 弘前大学, 弘前)
Discovery of Polysialic Acid in Microglia. Expression Changes of α2,8-Sialyltransferases During Activation of a Mouse Microglia Cell Line International conference
19th International Symposium on Glycoconjugates (July 15-20, 2007; Cairns, Australia)
Polysialic acids on O-glycans: Their occurrence, structural diversity, and biosynthesis International conference
Polysialic acid: Chemistry, Biology, Translational Aspects, 3rd International Meeting (Bad Lauterberg, Germany)
A short-term regulation of polysialic acid expression in microglia International conference
Gordon Research Conference on Glycobiology (Ventura, U.S.A.)
ポリシアル酸:普遍的存在、構造多様性および機能
北島健
第4回糖鎖科学コンソーシアムシンポジウム~糖鎖機能の解明からシステム糖鎖生物学への統合へ向けて~ (2006年10月23-24日;東京)
Discovery of Polysialic Acid in Microglia. Expression Changes of α2,8-Sialyltransferases During Activation of a Mouse Microglia Cell Line International conference
5th International Symposium on Glycosyltransferases (June 25-28, 2006; Tsukuba, Japan)
Development of a chemical method for detecting a unique sialic acid, cyclic neuraminic acid, in naturally-occurring sialyl glycoconjugates International conference
Pacifichem 2005 (2005.12; Hawaii, USA)
Significance of membrane microdomains in the carbohydrate-dependent cell-cell interactions during early development of medaka fish International conference
2nd Japan-The Netherlands Glycobiology Symposium (April 18-20, 2005; Utrecht, The Netherlands)
An essential role of carbohydrate-enriched membrane microdomains (rafts) in gastrulation of medaka fish, Oryzias latipes International conference
Gordon Research Conference on Glycobiology (Ventura, U.S.A.)
ポリシアル酸の鎖長多様性と神経系における新機能
北島健
第23回シアル酸研究会講演会「シアル酸と記憶」(2005年12月; 東京)
A carbohydrate-mediated binding of sperm gangliosides with the sperm binding protein in vitelline layer as a molecular base for the sea urchin sperm-egg interaction International conference
4th International Symposium on the Molecular and Cell Biology of Egg- and Embryo-Coats (MCBEEC2004) (2004.11; Ise, Japan)
Polysialic acid in mammary gland International conference
4th International Symposium on Glycosyltransferases GlycoT2004. (2004.11; Le Touquet, France)
生体膜マイクロドメインを通して糖鎖認識分子群を探究する
北島健
第53回高分子討論会「ここまできた糖鎖工学と化学生物学の展開」(2004.9.; 札幌)
Linkage and chain length diversities of the polysialic acid in animal glycoproteins International conference
Sialobiology 2004. 4th International Conference. (2004.7; St Andrews, UK)
糖脂質マイクロドメイン:細胞間相互作用を媒介する分子集合体
北島健
日本農芸化学会中部支部第140回例会. シンポジウム「ポスト・ポストゲノム:糖と脂質の最前線」(岐阜)
Identification and characterization of a new heat shock protein-like lectin on the egg surface of sea urchin International conference
21st International Lectin Meeting (2004.5; Shonan, Japan)
Identification of glycosylated alpha-lactoalbumin as endogenous substrate for beta-1,4-galactosyltransferase (GalT) in colostrum International conference
XVIth International Symposium on Glycoconjugates
Molecular cloning and developmental expression of two alpha-2,8-polysialyltransferases in rainbow trout ovary." International conference
XVIth International Symposium on Glycoconjugates
Sialic acid-dependent sperm raft-egg raft interactions at fertilization. International conference
XVIth International Symposium on Glycoconjugates (August 19-24, 2001The Hague, The Netherlands)
Biosynthesis of a major, carbohydrate-rich cortical galveolus glycoprotein (hyosophorin) during oogenesis of Oryzias latipes International conference
14th International Congress of Developmental Biology
Identification of adipo Q, an adipocyte specific glycoprotein, as a new oligosialic acid-containing glycoprotein and a possible substrate for the alpha2,8-sialyltransferase III (ST8Sia III) International conference
International Symposium on Protein Trafficking, Glycosylation, and human health
Di/oligosialic acid in glycoproteins: Differentiation-dependent expression in an adipocyte tissue specific glycoprotein, adipo Q. International conference
Gordon Research Conference on Glycobiology
The chicken Zp-C gene. Gene structure, granulosa-specific expression and promoter activity International conference
3rd International Symposium of the Molecular and Cellular Biology of the Egg and Embryo Extracellular Matrix
Expression and glycosylation of a major, carbohydrtate-rich, cortical alveolus glycoprotein (hyosophorin) during oogenesis of medaka fish, Oryzias latipes. International conference
3rd International Symposium of the Molecular and Cellular Biology of the Egg and Embryo Extracellular Matrix
Expression and glycosylation of a major, carbohydrtate-rich, cortical alveolus glycoprotein (hyosophorin) during oogenesis of medaka fish, Oryzias latipes International conference
3rd International Symposium of the Molecular and Cellular Biology of the Egg and Embryo Extracellular Matrix (August 27-September 1, Lake Tahoe, California, U.S.A.)
KDNの生合成に関与する酵素の同定および性質
北島 健
第21回日本糖質学会年会(2000年7月27-29日, 名古屋国際会議場, 名古屋)
Di- and oligosialic acids as novel carbohydrate epitopes in leukocytes. International conference
7th Conference on human leukocyte differentiation antigens
Di- and oligosialic acids as novel carbohydrate epitopes in leukocytes International conference
7th Conference on human leukocyte differentiation antigens (Harrogate, UK, June 20-24, 2000)
Cloning and characterization of N-acetylgalactosaminide (2,6-sialyltransferase (ST6GalNAc II) responsible for sialylation of rainbow trout egg polysialoglycoprotein. International conference
2nd International Symposium on Glycosyltransferase: Glycosyltransferases in the New Millenium
Spontaneous galactosylation of agalactoglycoproteins in colostrum. A possible role of milk 1,4-galactosylatransferase. International conference
2nd International Symposium on Glycosyltransferase: Glycosyltransferases in the New Millenium
Gametic cell rafts-mediated sperm-egg interaction at fertilization International conference
Invited Seminar at Loeb Health Research Institute (University of Ottawa, ON, Canada, May 8, 2000)
Biosynthesis of deaminoneuraminic acid (KDN) in mammalian cells International conference
2nd International Symposium on Glycosyltransferase: Glycosyltransferases in the New Millenium (May 12-14, 2000, The Hospital for Sick Children, Toronto, Canada)
動物細胞表面のシアロ糖鎖工学:N-アセチルノイラミン酸からデアミノノイラミン酸(KDN)へのin vitro改変
仲田大輔、松田 幹、北島 健
日本農芸化学会2000年度大会 ( 東京, 2000年3月31日-4月2日)
シアル酸は面白い~シアロバイオサイエンスへの招待
(財)科学技術交流財団「糖鎖材料生命工学研究会」セミナー (名古屋大学VBL; 11月24日 1999)
ニジマス卵巣a2,6-シアル酸転移酵素(ST6GalNAcII)およびa2,8-ポリシアル酸転移酵素(ST8Sia)のcDNAクローニングと卵形成過程における発現
朝比奈慎二、松野みどり、中瀬昌之、佐藤ちひろ、青木直人、松田幹、北島健
第72回日本生化学会大会
精子細胞膜の糖脂質ミクロドメインの受精における役割
第72回日本生化学会大会 シンポジウム講演 (横浜, 10月6-9日 1999)
A role of b-1,4-galactosyltransferase in in situ galactosylation of degalactosylated glycoproteins in colostrum. International conference
XVth International Symposium on Glycoconjugates
Glycosphingolipid-enriched microdomain on gametic cells as functional domain for sperm-egg interaction coupled with signal transduction International conference
Special Seminar at Department of Med: Biological Chemistry, University of California, Davis, U.S.A.
Egg receptor for sperm binds to gangliosides in the low density detergent-insoluble membrane (LD-DIM) domain of the sperm surface. Possible involvement of the LD-DIM in sperm-egg binding coupled with signal transduction during fertilization International conference
XVth International Symposium on Glycoconjugates (August 22-26, Hotel East 21, Tokyo, Japan 1999)
Glycosphingolipid-enriched microdomain on gametic cells as functional domain for sperm-egg interaction coupled with signal transduction International conference
Gordon Research Conference on Fertilization and Activation of the Development (July 25-30, Holderness School, Plymouth, New Hampshire, U.S.A. 1999)
新規なシアル酸含有糖タンパク質の生理活性
連続公開セミナー「糖鎖の新しい生理活性」第5回セミナー (京都大学農学部, 12月12日 1998)
Occurrence of oligosialic acid residues in vertebrate glycoproteins International conference
International Symposium on Sialobiology and Other Novel Forms of Glycosylation (Taipei, Taiwan, November 9-13, 1998)
オリゴシアル酸含有糖タンパク質の新しい化学的および免疫化学的解析法の開発と哺乳動物細胞における普遍的存在の証明
佐藤ちひろ、本田直輝、太田薫、福岡秀幸、井上貞子、松田幹、北島健
第71回日本生化学会大会 (名古屋、10.14-10.17 1998)
動物細胞におけるデアミノノイラミン酸(KDN)の生合成経路およびKDN複合糖質の発現の調節機構の解析
北島健、安形高志、仲田大輔、松田幹、Frederic A. Troy, II
第71回日本生化学会大会 シンポジウム「糖鎖生物学の新たな展開と可能性:糖鎖合成・発現の調節機構」
Expression of alpha2,8-linked oligosialic acid-containing glycoproteins in mammalian cells, depending on development, cell differentiation, and overexpression of polysialyltransferase genes International conference
XIXth International Carbohydrate Symposium
糖タンパク質における新しいシアル酸含有糖鎖構造とその機能
北島 健
平成10年度日本農芸化学会 シンポジウム「糖鎖の精密構造とその機能:生命現象に関わる糖鎖」(名古屋、名城大学、3月31日~4月3日 1998)
Synthesis of neoglycoconjugates containing deaminated neuraminic acid (KDN) using rat liver α2,6-sialyltransferase. International conference
10th Annual Meeting of Japanese Association for Animal Cell Technology
Structure and physiological activities of hyosophorin, a cortical alveolus glycoprotein of fish eggs International conference
2nd International Symposium on the Molecular and Cell Biology of Egg- and Embryo-coats
Frequent occurrence of oligosialyl units in vertebrate glycoprotiens as evidenced by new chemical and immunochemical methods International conference
XIVth International Symposium on Glycoconjugates
Oligosialic acid-containing glycoproteins occur in vertebrates more frequently than recognized until now: their distribution, function, and biosynthesis International conference
Gordon Research Conference on Glycobiology
新しい機能性糖鎖を探索する
北島 健
第32回糖鎖生命科学セミナー (東京工業大学、1月10日 1997)
新しい複合糖質の発見と研究展開
北島 健
講演会「糖鎖工学:多様な生命現象へのアプローチ」
Purification, characterization and catalytic mechanism of a novel sialidase, deaminoneuraminidase (KDNase), from Sphingobacterium multivorum International conference
1st. Austrasia Conference on the Chemistry and Biochemistry of Sialic Acid-Recognising Proteins
Deaminoneuraminic acid (KDN)-containing glycoconjugates: Biological functions and potential usefulness in glycotechnology International conference
First International Symposium on Glycobiology: 3rd Generation of biotechnology as a new frontier in biological science
魚卵に学ぶ. N-グリコシド型糖タンパク質の構造と機能
北島 健
平成7年度日本水産学会年会 ミニシンポジウム「海洋生命科学における糖鎖生物学・工学」
A possible polysialylation signal in the core glycan chain of N-CAM International conference
13th International Symposium on Glycoconjugates
Unique structures and structural chains of the cortical alveolar-derived glycopolyproteins in fish eggs upon fertilization and during early development International conference
3rd International Marine Biotechnology Conference (Tromso, Norway, August 7-12, 1994)
Discovery, purification, and properties of KDNase devoid of sialidase activity: Is KDN a sialic acid? International conference
17th International Carbohydrate Symposium (Ottawa, Canada, July 17-22, 1994)
自然科学機構基礎生物学研究所個別共同利用研究
基礎生物科学研究所との共同研究
東京工業大学との共同研究
自然科学機構基礎生物学研究所個別共同利用研究
自然科学機構基礎生物学研究所個別共同利用研究
ポリシアル酸認識機構を基盤とする精神疾患と癌の診断・治療の技術革新研究
Grant number:19ae0101069h0004 2018.4 - 2021.3
次世代治療・診断実現のための創薬基盤技術開発事業 糖鎖利用による革新的創薬技術開発事業
佐藤ちひろ
Authorship:Coinvestigator(s) Grant type:Competitive
Grant amount:\1000000
海洋脊索動物の構造と機能グライコミクス
2009.4 - 2010.3
科学技術振興機構 戦略的国際科学技術協力推進事業
Grant type:Competitive
科学技術振興機構 戦略的国際科学技術協力推進事業
受精および初期発生における糖鎖の役割解明とその応用に関する研究
2004.4 - 2007.3
ヒューマンサイエンス振興財団 創薬等ヒューマンサイエンス総合研究事業 KH21014
Grant type:Competitive
The sialate sulfotransferase in vertebrates: Identification and significance
Grant number:19K05812 2019.4 - 2022.3
Authorship:Principal investigator
Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )
先天性糖鎖修飾不全症の創薬医療のためのモデルメダ カの樹立と統合的病態解明法の確立
2018.4 - 2021.3
公益財団法人小林国際奨学財団 研究助成金
北島健
Authorship:Principal investigator Grant type:Competitive
Grant amount:\3500000 ( Direct Cost: \3500000 )
糖鎖生物学
Grant number:060503 2018.4 - 2019.3
日本学術振興会 研究成果公開促進費(学術図書)
北島健
Authorship:Principal investigator Grant type:Competitive
Grant amount:\2236000
先天性糖鎖合成異常症の新しい治療薬開発の基盤確立
Grant number:UEHARAZAIDAN-D-18-00087R1 2017.4 - 2019.3
上原記念生命科学財団 研究助成金
Authorship:Principal investigator Grant type:Competitive
Grant amount:\5000000 ( Direct Cost: \4500000 、 Indirect Cost:\500000 )
デアミノシアル酸とポリシアル酸の医用応用に向けた分子基盤の確立
Grant number:芝049-No1-04-助成決定-4 2016.4 - 2018.3
公益信託 医用薬物研究奨励富岳基金 研究助成金
北島健
Authorship:Principal investigator Grant type:Competitive
Grant amount:\2000000 ( Direct Cost: \2000000 )
初期胚表面に存在する巨大糖鎖の機能とその分子機構の解明
2010 - 2013.3
科学研究費補助金 基盤研究(B),課題番号:22380187
北島 健
Authorship:Principal investigator
T細胞と抗原提示細胞の相互作用における接着分子CADM1とCRTAMの役割
2009.11 - 2010.3
Grant-in-Aid for Scientific Research
Authorship:Principal investigator
細胞外熱ショックタンパク質70-酸性脂質複合体の構造と生理学的役割の解明
2009.4 - 2010.3
Grant-in-Aid for Scientific Research
Authorship:Principal investigator
動物精子表面糖鎖による新しい受精能制御の分子機構の解明
2007.4 - 2010.3
科学研究費補助金 基盤研究(B)(一般),課題番号:19380192
北島 健
Authorship:Principal investigator
Roles of acidic glycoconjugates in mammalian fertilization
2005.4 - 2007.3
Grant-in-Aid for Scientific Research
Authorship:Principal investigator
細胞接着に関わるシアル酸の構造変化と細胞接着制御の解明
2002.11 - 2008.3
科学研究費補助金 科学技術振興機構
神奈木玲児
Authorship:Coinvestigator(s)
細胞表面に見出される新しい酸性糖鎖の機能に関する共同研究
1998.1 - 1999.12
科学研究費補助金 国際学術研究
Authorship:Principal investigator
科研費
糖タンパク質糖鎖におけるオリゴシアル酸鎖の発見とその普遍的存在分布の証明
1998.1 - 1999.12
科学研究費補助金 基盤研究(C)(2)
Authorship:Principal investigator
科研費
細胞間接着における糖質ー糖質間相互作用の役割と分子機構の解明
1998.1 - 1998.12
科学研究費補助金 特定領域研究(A)(2)
Authorship:Principal investigator
科研費
細胞表面に見出される新しい酸性糖鎖の機能に関する共同研究
1997.1 - 1998.12
科学研究費補助金 国際学術研究
Authorship:Principal investigator
科研費
細胞間接着における糖質ー糖質間相互作用の役割と分子機構の解明
1997.1 - 1997.12
科学研究費補助金 重点領域研究
Authorship:Principal investigator
科研費
デアミノノイラミン酸残基特異的な新規シアリターゼ(KDNase)
1996.1 - 1996.12
科学研究費補助金 萌芽的研究
Authorship:Principal investigator
科研費
細胞表面に見出された新規ポリシアル酸、KDN、硫酸化糖鎖の機能に関する共同研究
1996.1 - 1996.12
科学研究費補助金 国際学術研究
Authorship:Principal investigator
科研費
デアミノノイラミン酸(KDN)残基をもつ新しい生理活性複合糖質の開発と応用
1995.1 - 1996.12
科学研究費補助金 試験研究(B)
Authorship:Principal investigator
科研費
デアミノノイラミン酸残基特異的な新規シアリダーゼ(KDNase)
1995.1 - 1995.12
科学研究費補助金 一般研究(C)
Authorship:Principal investigator
科研費
哺乳動物正常及び腫瘍細胞におけるKDN-複合糖質の分布及び機能に関する共同研究
1995.1 - 1995.12
科学研究費補助金 国際学術研究
Authorship:Principal investigator
科研費
新規デアミノノイラミニダーゼとその製造方法
北島健
新規グリコペプチダーゼとその製造方法
井上康男、井上貞子、北島健
農学セミナー
2020
生物化学I
2020
糖鎖生物学特論I
2020
Bioorganic Chemistry (G30)
2020
修士論文研究2
2020
修士論文研究1
2020
生命農学演習2
2020
生命農学演習1
2020
Sialobiology: a fascinating area of study to solve the mystery of glycans
2019.5
Level:Postgraduate Country:Austria
細胞表面情報分子
1998.4 - 1999.3 (岐阜薬科大学)
応用生物科化学特論
1998.4 - 1999.3 (静岡大学 農学部)
生体高分子学
1997.4 - 1998.3 (東京大学 大学院理学系研究科)
長野県飯田高等学校への出前講義
Role(s):Appearance, Lecturer, Planner
長野県飯田高等学校 高校1年生進路研修 2019.12
中華人民共和国深セン明徳実験学校
Role(s):Lecturer, Informant
中華人民共和国深セン明徳実験学校 学内見学とセミナー高校3年生 2019.10
長野県飯田高等学校の進路研修
Role(s):Appearance, Planner
長野県飯田高等学校 高校2年生進路研修 2019.9
名古屋大学オープンキャンパス研究紹介
Role(s):Informant, Planner
名古屋大学 名古屋大学オープンキャンパス 2019.8
体内のマンノース濃度を保つ仕組みを解明:進化の過程で選択された糖代謝経路 Internet
名古屋大学広報および筑波大学広報 共同プレスリリース https://www.nagoya-u.ac.jp/about-nu/public-relations/researchinfo/upload_images/20210216_agr1.pdf 2021.2
Associate Editor of Glycobiology International contribution
Role(s):Planning, management, etc., Review, evaluation
Socity for Glycobiology 2021.1 - 2021.3
Editorial Board of the Journal Biological Chemistry International contribution
Role(s):Review, evaluation, Peer review
American Society of Biochemistry and Molecular Biology 2020.4 - 2021.3
第38回日本糖質学会年会(日本糖質学会創設40周年記念大会) International contribution
Role(s):Planning, management, etc.
北島健 2019.8
Editorial Board Member of Glycoconjugate Journal International contribution
Role(s):Review, evaluation, Peer review
Society for Glycobiology 2020.4 - 2021.12
糖鎖科学中部拠点事務局 International contribution
Role(s):Planning, management, etc., Review, evaluation
糖鎖科学名古屋拠点 2020.4 - 2021.3
日本農芸化学会中部支部会評議員 International contribution
Role(s):Planning, management, etc., Review, evaluation
日本農芸化学会中部支部 2020.4 - 2021.3
日本糖鎖科学コンソーシアム常任幹事 International contribution
Role(s):Planning, management, etc., Review, evaluation
日本糖鎖科学コンソーシアム 2020.4 - 2021.3
日本生化学会評議員 International contribution
Role(s):Planning, management, etc., Review, evaluation
日本生化学会 2020.4 - 2021.3
日本糖質学会評議員 International contribution
Role(s):Planning, management, etc., Review, evaluation
日本糖質学会 2020.4 - 2021.3
日本糖質学会理事 International contribution
Role(s):Planning, management, etc., Review, evaluation
日本糖質学会 2020.4 - 2021.3
Editorial Board Member of Glycobiology International contribution
Role(s):Review, evaluation
Society for Glycobiology 2020.1 - 2020.12