糖鎖機能の糖鎖工学的利用

名古屋大学　生物分子応答研究センター・助教授

2000.4 - 2003.3

名古屋大学大学院生命農学研究科　助教授

1998.4 - 2000.3

名古屋大学農学部 助教授

1996.6 - 1998.3

東京大学大学院理学系研究科 助手

1994.4 - 1996.5

東京大学理学部 助手

1989.4 - 1994.3

日本学術振興会 特別研究員PD

1987.4 - 1989.3

Forum: Carbohydrate Coming of Age

2001.4 - 2008.3

Society for Glycobiology

日本分子生物学会

日本発生生物学会

Comparative Studies of Polysialic Acids Derived from Five Different Vertebrate Brains

Yang Yi, Murai Ryo, Takahashi Yuka, Mori Airi, Hane Masaya, Kitajima Ken, Sato Chihiro

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 21 ( 22 )   2020.11

Polysialylation and disease Invited Reviewed

Mol Aspects Med     2020.8

Combinational Analyses with Multiple Methods Reveal the Existence of Several Forms of Polysialylated Neural Cell Adhesion Molecule in Mouse Developing Brains

Mori Airi, Yang Yi, Takahashi Yuka, Hane Masaya, Kitajima Ken, Sato Chihiro

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 21 ( 16 )   2020.8

Systems glycomics of adult zebrafish Invited Reviewed International coauthorship

Ken Kitajima, Nao Yamakawa, Chihiro Sato, Yann Guerardel

Journal of Japanese Biochemical Society   Vol. 92 ( 3 ) page： 349 - 359   2020.6

Discovery of a new sialic acid binding region that regulates Siglec-7

Yamakawa Nao, Yasuda Yu, Yoshimura Atsushi, Goshima Ami, Crocker Paul R., Vergoten Gerard, Nishiura Yuji, Takahashi Takashi, Hanashima Shinya, Matsumoto Kana, Yamaguchi Yoshiki, Tanaka Hiroshi, Kitajima Ken, Sato Chihiro

SCIENTIFIC REPORTS   Vol. 10 ( 1 )   2020.5

Identification and characterization of a novel, versatile sialidase from a Sphingobacterium that can hydrolyze the glycosides of any sialic acid species at neutral pH

Iwaki Yuya, Matsunaga Emiko, Takegawa Kaoru, Sato Chihiro, Kitajima Ken

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 523 ( 2 ) page： 487 - 492   2020.3

Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice

Ikegami Keisuke, Saigoh Kazumasa, Fujioka Atsuko, Nagano Mamoru, Kitajima Ken, Sato Chihiro, Masubuchi Satoru, Kusunoki Susumu, Shigeyoshi Yasufumi

SCIENTIFIC REPORTS   Vol. 9   2019.9

Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D-2 and adenosine A(2A) receptors

Lin Chien-Yu, Lai Hsing-Lin, Chen Hui-Mei, Siew Jian-Jing, Hsiao Cheng-Te, Chang Hua-Chien, Liao Kuo-Shiang, Tsai Shih-Chieh, Wu Chung-Yi, Kitajima Ken, Sato Chihiro, Khoo Kay-Hooi, Chern Yijuang

TRANSLATIONAL PSYCHIATRY   Vol. 9   2019.8

Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain

Abe Chikara, Yi Yang, Hane Masaya, Kitajima Ken, Sato Chihiro

SCIENTIFIC REPORTS   Vol. 9   2019.7

Structural Diversity and Evolution of Sialic Acids

Kitajima Ken

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY   Vol. 31 ( 181 ) page： SE18 - SE20   2019.7

N-linked mannose glycoconjugates on shrimp thrombospondin, pmTSP-II, and their involvement in the sperm acrosome reaction

Timklay Wauranittha, Magerd Sirilug, Sato Chihiro, Somrit Monsicha, Watthammawut Atthaboon, Senarai Thanyaporn, Weerachatyanukul Wattana, Kitajima Ken, Asuvapongpatana Somluk

MOLECULAR REPRODUCTION AND DEVELOPMENT   Vol. 86 ( 4 ) page： 440 - 449   2019.4

Sialic Acids in Neurology

SIALIC ACIDS, PT II: BIOLOGICAL AND BIOMEDICAL ASPECTS   Vol. 76   page： 1 - 64   2019

Technologies to Elucidate Functions of Glycans

Furukawa Koichi, Ohmi Yuhsuke, Kondo Yuji, Ohkawa Yuki, Tajima Orie, Furukawa Keiko, Honke Koichi, Inokuchi Jin-ichi, Gu Jianguo, Kadomatsu Kenji, Nadanaka Satomi, Kitagawa Hiroshi, Nishihara Shoko, Nomura Kazuya, Oka Shogo, Ito Makoto, Kitajima Ken, Natsuka Shunji, Kanagawa Motoi, Ishimizu Takeshi, Fujiyama Kazuhito, Chiba Yasunori, Osada Hiroyuki

GLYCOSCIENCE: BASIC SCIENCE TO APPLICATIONS: INSIGHTS FROM THE JAPAN CONSORTIUM FOR GLYCOBIOLOGY AND GLYCOTECHNOLOGY (JCGG)     page： 87 - 124   2019

Sialic Acids in Neurology Invited Reviewed

Sato C, Kitajima K

Adv Carbohydr Chem Biochem   Vol. 76   page： 1 - 64   2019

Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns

Yamakawa Nao, Vanbeselaere Jorick, Chang Lan-Yi, Yu Shin-Yi, Ducrocq Lucie, Harduin-Lepers Anne, Kurata Junichi, Aoki-Kinoshita Kiyoko F., Sato Chihiro, Khoo Kay-Hooi, Kitajima Ken, Guerardel Yann

NATURE COMMUNICATIONS   Vol. 9   2018.11

Positive selection on schizophrenia-associated ST8SIA2 gene in post-glacial Asia

Fujito Naoko T., Satta Yoko, Hane Masaya, Matsui Atsushi, Yashima Kenta, Kitajima Ken, Sato Chihiro, Takahata Naoyuki, Hayakawa Toshiyuki

PLOS ONE   Vol. 13 ( 7 )   2018.7

ポリシアル酸化 Invited Reviewed

佐藤ちひろ、北島健

膜タンパク質; 特集 「タンパク質・核酸の分子修飾 Ⅲ. 細胞膜での分子修飾」）生体の科学   Vol. 69 ( 5 ) page： 502 - 503   2018

Identification of KDN-Gangliosides

Kitajima Ken

GANGLIOSIDES: METHODS AND PROTOCOLS   Vol. 1804   page： 429 - 435   2018

Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4

Mori Airi, Hane Masaya, Niimi Yuki, Kitajima Ken, Sato Chihiro

GLYCOBIOLOGY   Vol. 27 ( 9 ) page： 834-846   2017.9

Invisible glycoproteins with unusually high carbohydrate content in animal gametic cells

Kitajima Ken

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 254   2017.8

Chemical Synthesis and Evaluation of a Disialic Acid-Containing Dextran Polymer as an Inhibitor for the Interaction between Siglec 7 and Its Ligand

Yamaguchi Sho, Yoshimura Atsushi, Yasuda Yu, Mori Airi, Tanaka Hiroshi, Takahashi Takashi, Kitajima Ken, Sato Chihiro

CHEMBIOCHEM   Vol. 18 ( 13 ) page： 1194-1203   2017.7

Alpha-2 macroglobulin as a region-specific secretory protein in male reproductive tract, and its dynamics during sperm transit toward the female spermatheca in the blue crab

Senarai Thanyaporn, Vanichviriyakit Rapeepun, Miyata Shinji, Sato Chihiro, Sretarugsa Prapee, Weerachatyanukul Wattana, Kitajima Ken

MOLECULAR REPRODUCTION AND DEVELOPMENT   Vol. 84 ( 7 ) page： 585-595   2017.7

Chlorpromazine Increases the Expression of Polysialic Acid (PolySia) in Human Neuroblastoma Cells and Mouse Prefrontal Cortex

Abe Chikara, Nishimura Saki, Mori Airi, Niimi Yuki, Yang Yi, Hane Masaya, Kitajima Ken, Sato Chihiro

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 18 ( 6 )   2017.6

Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation

Go Shinji, Go Shiori, Veillon Lucas, Ciampa Maria Grazia, Mauri Laura, Sato Chihiro, Kitajima Ken, Prinetti Alessandro, Sonnino Sandro, Inokuchi Jin-ichi

JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 292 ( 17 ) page： 7040-7051   2017.4

Diverse subcellular localizations of the insect CMP-sialic acid synthetases

Di Wu, Fujita Akiko, Hamaguchi Kayo, Delannoy Philippe, Sato Chihiro, Kitajima Ken

GLYCOBIOLOGY   Vol. 27 ( 4 ) page： 329-341   2017.4

Synthesis of end-functionalized glycopolymers containing alpha(2,8) disialic acids via pi-allyl nickel catalyzed coordinating polymerization and their interaction with Siglec-7

Ohira Shuichi, Yasuda Yu, Tomita Ikuyoshi, Kitajima Ken, Takahashi Takashi, Sato Chihiro, Tanaka Hiroshi

CHEMICAL COMMUNICATIONS   Vol. 53 ( 3 ) page： 553-556   2017.1

Synthesis of End-functionalized Glycopolymers Containing α(2,8) Disialic Acids by π-Allyl Nickel Catalyzed Coordinating Polymerization and Their Interaction with Siglec-7.

Ohira S, Yasuda Y, Tomita I, Kitajima K, Takahashi T, Sato C, Tanaka H.

  Vol. 53 ( 3 ) page： 553-556   2017.1

Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.

Go S, Go S*, Veillon L, Ciampa MG, Mauri L, Sato C, Kitajima K, Prinetti A, Sonnino S, Inokuchi JI.

J Biol Chem.     2017

Diverse subcellular localizations of the insect CMP-sialic acid synthetases

Wu D, Fujita A, Hamaguchi K, Delannoy P, Sato C, Kitajima K.

    page： Epub ahead of print   2016.12

Relationship between ST8SIA2, polysialic acid and its binding molecules, and psychiatric disorders.

Sato C, Hane M, Kitajima K.

Biochim Biophys Acta.   Vol. 1860 ( 8 ) page： 1739-1752   2016

The AMOR Arabinogalactan Sugar Chain Induces Pollen-Tube Competency to Respond to Ovular Guidance.

Mizukami AG, Inatsugi R, Jiao J, Kotake T, Kuwata K, Ootani K, Okuda S, Sankaranarayanan S, Sato Y, Maruyama D, Iwai H, Garénaux E, Sato C, Kitajima K, Tsumuraya Y, Mori H, Yamaguchi J, Itami K, Sasaki N, Higashiyama T.

Curr Biol.   Vol. 26 ( 8 ) page： 1091-1097   2016

Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.

Hane M**, Kitajima K, Sato C.

Biochem Biophys Res Commun   Vol. 478 ( 3 ) page： 1123-1129   2016

Discovery, primary and crystal structures, and capacitation-related properties of a prostate-derived heparin-binding protein WGA16 from boar sperm.

Garénaux E, Kanagawa M, Tsuchiyama T, Hori K, Kanazawa T, Goshima A, Chiba M, Yasue H, Ikeda A, Yamaguchi Y, Sato C, and Kitajima K.

J. Biol. Chem.   Vol. 290 ( ９ ) page： 5484-5501   2015

Protective effects of polysialic acid on proteolytic cleavage of FGF2 and ProBDNF/BDNF

Hane M*, Matsuoka S**, Ono S**, Miyata S, Kitajima K, Sato C.

  Vol. 25 ( 10 ) page： 1112-1124   2015

Ganglioside contained in the neuronal tissue-enriched acidic protein of 22 kDa (NAP-22) fraction prepared from the detergent-resistant membrane microdomain of rat brain inhibits the phosphatase activity of calcineurin.

Kobayashi Y, da Silva R, Kumanogoh H, Miyata S, Sato C, Kitajima K, Nakamura S, Morita M, Hayashi F, Maekawa S.

  Vol. 93 ( ９ ) page： 1462-1470   2015

Sulfatide-Hsp70 interaction promotes Hsp70 clustering and stabilizes binding to unfolded protein.

Harada Y**, Sato C, and Kitajima K.

  Vol. ５ ( ２ ) page： 958-973   2015

Rapid trimming of cell surface polysialic acid (polySia) by exovesicular sialidase triggers release of preexisting surface neurotrophin.

Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OM, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K, and Sato C.

J. Biol. Chem.   Vol. 290 ( 21 ) page： 13202-13214   2015

Disialic, oligosialic and polysialic acids: distribution, functions and related disease Reviewed

Sato C, Kitajima K

Journal of Biochemistry   Vol. 154 ( 2 ) page： 115-136   2014.6

Comparison of analytical methods to detect polysialic acid. Reviewed

Nishimura S, Hane M, Niimi Y, Miyata S, Kitajima K, and Sato C

Journal of Glycomics and Lipidomics   Vol. 4 ( 2 ) page： 113   2014

Interaction of 70-kDa heat shock protein with glycosaminoglycans and acidc glycopolymers. Reviewed

Harada Y, Garenaux E, Nagatsuka T, Uzawa H, Nishida Y, Sato C, Kitajima K

Biochem Biophys Res Commun.   Vol. 453   page： 229-234   2014

Polysialic acid: Biosynthesis, novel functions and applications. Reviewed

Colley K, Kitajima K, Sato C

Critical Reviews in Biochemistry and Molecular Biology     page： 1-35   2014

Identification of novel isoforms of vitellogenin expressed in ascidian eggs. Reviewed

Akasaka M, Kato KH, Kitajima K, Sawada H.

J Exp Zool Part B Mol Dev Evol.   Vol. 320 ( 2 ) page： 118-128   2013

Occurrence of free deaminoneuraminic acid (KDN)-containing complex-type N-glycans in human prostate cancers. Reviewed

Yabu M, Korekane H, Takahashi H, Ohigashi H, Ishikawa O, Hatano K, Nonomura N, Sato C, Kitajima K, Miyamoto Y.

Glycobiology   Vol. 26 ( 6 ) page： 634-642   2013

Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid. Reviewed

Ono S, Hane M, Kitajima K, Sato C.

J Biol Chem.   Vol. 287 ( 6 ) page： 3710-3722   2012

Pig sperm membrane microdomains contain a highly glycosylated 15-25-kDa wheat germ agglutinin-binding protein. Reviewed

Kasekarn W, Kanazawa T, Hori K, Tsuchiyama T, Xue L, Garénaux E, Kongmanas K, Tanphaichitr N, Yasue H, Sato C, Kitajima K.

Biochem. Biophys. Res. Commun.   Vol. 426 ( 3 ) page： 356-362   2012

Metabolism of Vertebrate Amino Sugars with N-glycolyl Groups: Resistance of α2-8-linked N-glycolylneuraminic Acid to Enzymatic Cleavage. Reviewed

Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woods R, Varki A.

J Biol Chem.   Vol. 287 ( 34 ) page： 28917-28931   2012

Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons. Reviewed

Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T.

J Biol Chem.   Vol. 287 ( 18 ) page： 14816-14826   2012

Structural and functional impairments of polysialic acid (polySia)-neural cell adhesion molecule (NCAM) synthesized by a mutated polysialyltransferase of a schizophrenic patient. Reviewed

Hane M, Sumida M, Kitajima K, Sato C

Pure Appl Chem.   Vol. 84 ( 9 ) page： 1895-1906   2012

Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution. Reviewed

Guérardel Y, Chang LY, Fujita A**, Coddeville B, Maes E, Sato C, Harduin-Lepers A, Kubokawa K, Kitajima K.

Glycobiology   Vol. 22 ( 4 ) page： 479-491   2012

Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid. Reviewed

Ono, S., Hane, M., Kitajima, K., and Sato, C.

J Biol Chem.   Vol. 287 ( 6 ) page： 3710-3722   2012

New function of polysialic acid and its involvement in neural activities. Invited Reviewed

Sato, C., and Kitajima, K.

Seikagaku   Vol. 83 ( 3 ) page： 189-196   2011.3

Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia Reviewed

Isomura, R, Kitajima, K., and Sato, C.

Journal of Biological Chemistry   Vol. 286 ( 24 ) page： 21535-21545   2011

New function of polysialic acid and its relationship to schizoprenia. Invited Reviewed

Sato, C., and Kitajima, K.

Trends Glycsci Glycotech   Vol. 23 ( 133 ) page： 221-238   2011

Mechanism regulating Ca2+-dependent mechanosensory behaviour in sea urchin spermatozoa. Reviewed

Kambara, Y., Shiba, K., Yoshida, M., Sato, C., Kitajima, K., and Shingyoji, C.

Cell Struct Funct   Vol. 36 ( 1 ) page： 69-82   2011

Co-expression of two distinct polysialic acids, α2,8- and α2,9-linked polymers of N-acetylneuraminic acid, in distinct glycoproteins and glycolipids in sea urchin sperm Reviewed

Miyata, S., Yamakawa, N., Toritama, M., Sato, C., and Kitajima, K.

Glycobiology   Vol. 21 ( 12 ) page： 1596-1605   2011

Extensive enrichment of N-glycolylneuraminic acid in extracellular sialoglycoproteins abundantly synthesized and secreted by human cancer cells. Reviewed

Sadako Inoue, Chihiro Sato., and Ken Kitajima

Glycobiology   Vol. 20   page： 752-762   2010

Survival signals of hepatic stellate cells in liver regeneration are regulated by glycosylation changes in rat vitronectin, especially decreased sialylation. Reviewed

Kotone Sano, Yasunori Miyamoto, Nana Kawasaki, Noritaka Hashii, Satsuki Itoh, Misaki Murase, Kimie Date, Miki Yokoyama, Chihiro Sato, Ken Kitajima, and Haruko Ogawa

J. Biol. Chem.   Vol. 285   page： 17301-17309   2010

Developmental stage-dependent expression of an α2,8- trisialic acid unit on glycoproteins in mouse brain. Reviewed

Inoko, E., Nishiura, Y., Tanaka, H., Takahashi, T., Furukawa, K., Kitajima, K., and Sato, C.

Glycobiology   Vol. 20   page： 916-928   2010

Human KDN (deaminated neuraminic acid) and its elevated expression in cancer cells: mechanism and significance. Reviewed

Inoue, S., Kitajima, K., Sato, C., and Go, S.

Adv Exp Med Biol   Vol. 705   page： 669-678   2010

*Membrane microdomains from early gastrula embryos of medaka, Oryzias latipes are a plat form of E-cadherin and carbohydrate-mediated cell-cell interactions during epiboly Reviewed

Adachi T., Sato, C., Kishi, Y., Totani, K., Murata, T., Usui, T., and Kitajima, K

Glycoconjugate J   Vol. 26   page： 285-99   2009

Complex formation of a brain-derived neurotrophic factor and glycosaminoglycans. Reviewed

Kanato, Y., Ono, S., Kitajima, K. and Sato, C.

Biosci. Biotech. Biosci.   Vol. 73   page： 2735-2741   2009

Developmental regulation of oligosialylation in zebrafish. Reviewed

Chang LY, Harduin-Lepers A, Kitajima K, Sato C, Huang CJ, Khoo KH, Guérardel Y.

Glycoconjugate J   Vol. 26   page： 247-61   2009

Direct binding of polysialic acid to a brain-derived neurotrphic factor depends on the degree of polymerization. Reviewed

Kanato, Y., Kitajima, K. Sato, C.

Glycobiology   Vol. 12   page： 1044-1053   2008

Identification of an inflammation-inducible serum protein recognized by anti-disialic acid antibodies as carbonic anhydrase II Reviewed

Yasukawa, Z., Sato, C., and Kitajima, K.

J. Biochem.   Vol. 141   page： 429-441   2007

Glycobiology of polysialic acids on sea urchin gametes Reviewed

Miyata, S., Sato, C., and Kitajima, K.

Trends Glycosci. Glycotech.   Vol. 19   page： 83-95   2007

*Membrane microdomain formation is crucial in epiboly during gastrulation of medaka. Reviewed

Adachi, T., Sato, C., and Kitajima, K.

Biochem. Biophys. Res. Commun.   Vol. 358   page： 848-853   2007

Development of sensitive chemical and immunochemical methods for detecting sulfated sialic acids and their application to glycoconjugates from sea urchin sperm and eggs Reviewed

Yamakawa, N., Sato, C., Miyata, S., Maehashi, E., Toriyama, M, Sato, N, Furuhata, K., and Kitajima, K.

Biochimie   Vol. 89   page： 1396-1408   2007

*Hypoxia-enhanced expression of free deaminoneuraminic acid in human cancer cells Reviewed

Go, S., Sato, C., Yin, J., Kannagi, R., and Kitajima, K.

Biochem. Biophys. Res. Commun.   Vol. 357   page： 537-542   2007

*Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase Reviewed

Fujita , A., Sato, C., and Kitajima, K.

Biochem. Biophys. Res. Commun.   Vol. 355   page： 174-180   2007

Complex formation of 70-kDa heat shock protein with acidic glycolipids and phospholipids Reviewed

Harada, Y., Sato, C., and Kitajima, K.

Biochem. Biophys. Res. Commun.   Vol. 353   page： 655-660   2007

The rainbow trout CMP-sialic acid synthetase utilizes a nuclear localization signal different from that identified in the mouse enzyme. Reviewed

Tiralongo J, Fujita A, Sato C, Kitajima K, Lehmann F, Oschlies M, Gerardy-Schahn R, Münster-Kühnel AK.

Glycobiology   Vol. 17   page： 945-954   2007

Oral ingestion of mannose alters the expression level of deaminoneuraminic acid (KDN) in mouse organs Reviewed

Go, S., Sato, C., and Kitajima, K.

Glycoconjugate J.   Vol. 23   page： 409-419   2006

*Flagellasialin: a novel sulfated alpha2,9-linked polysialic acid glycoprotein of sea urchin sperm flagella Reviewed

Miyata, S., Sato, C., Kumita, H., Toriyama, M., Vacquier, V. D., and Kitajima, K.

Glycobology   Vol. 166   page： 1229-1241   2006

KDN (Deaminated neuraminic acid): Dreamful past and exciting future of the newest member of the sialic acid family Reviewed

Inoue, S. and Kitajima, K.

Glycoconjugate J.   Vol. 23   page： 277-290   2006

Involvement of the alpha2,8-Polysialyltransferases II/STX and IV/PST in the Biosynthesis of Polysialic Acid Chains on the O-Linked Glycoproteins in Rainbow Trout Ovary Reviewed

Asahina, S., Sato, C., Matsuno, M., Matsuda, T., Colley, K., and Kitajima, K.

J. Biochem.   Vol. 140   page： 687-701   2006

Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands, as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activity Reviewed

Nakatani, H., Aoki, N., Nakagawa, Y., Jin-No, S., Aoyama K, Oshima, K., Ohira, S., Sato, C., Nadano, D., Matsuda, T.

Biochem J.   Vol. 395   page： 21-30   2006

Hypoxic culture induces expression of Sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells Reviewed

Yin, J., Hashimoto, A., Izawa, M., Miyazaki, K., Chen G-Y., Takematsu, H., Kozutsumi, Y., Suzuki, A., Furuhata, K., Cheng, F.-L. Lin, C.-H., Sato, C., Kitajima, K., and Kannagi, R.

Cancer Res.   Vol. 66   page： 2937-2945   2006

N-Linked oligosaccharides on chondroitin 6-sulfotransferase-1 are required for production of the active enzyme, golgi localization, and sulfotransferase activity toward keratan sulfate Reviewed

Yusa, A., Kitajima, K., and Habuchi, O.

J. Boil. Chem.   Vol. 281   page： 20393-20403   2006

Identification of disialic acid-containing glycoproteins in mouse serum: a novel modification of immunoglobulin light chains, vitronectin, and plasminogen Reviewed

Yasukawa, Z., Sato, C., Sano, K., Ogawa, H. and Kitajima, K.

Glycobiology   Vol. 166   page： 651-665   2006

Development of a simple and efficient method for assaying cytidine monophosphate sialic acid synthetase activity using an enzymatic reduced nicotinamide adenine dinucleotide/oxidized nicotinamide adenine dinucleotide converting system Reviewed

Fujita, A., Sato, C., Munster-Kuhnel, A.-K., Gerardy-Schahn, R., and Kitajima, K.

Anal. Biochem.   Vol. 337   page： 12-21   2005

Inflammation-dependent changes in α2,3-, α2,6-, and α2,8-sialic acid glycotopes on serum glycoproteins in mouse Reviewed

Yasukawa, Z., Sato, C., and Kitajima, K.

Glycobiology   Vol. 15   page： 827-837   2005

Distal myopathy with rimmed vaculoes: Impared O-glycan formation in muscular glycoproteins Reviewed

Tajima, Y., Uyama, E., Go, S., Sato, C., Tao, N., Kotani, M., Hino, H., Suzuki, A., Sanai, Y., Kitajima, K., and Sakuraba, H.

Amer. J. Pathol.   Vol. 166   page： 1121-1130   2005

Probing a CMP-Kdn synthetase by 1H, 31P and STD NMR spectroscopy Reviewed

Haselhorst, T., Munster-Kuhnel, A.-K., Stolz, A., Oschlies, M., Tiralongo, J., Kitajima, K., Gerardy-Schahn, R., and von Itzstein, M.

Biochem. Biophys. Res. Commun.   Vol. 327   page： 565-570   2005

N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulfotransferase-1 Reviewed

Yusa, A., Kitajima, K., and Habuchi, O.

Biochem. J.   Vol. 388   page： 115-121   2005

A major flagellum sialoglycoprotein in sea urchin sperm contains a novel polysialic acid, an α2,9-linked poly-N-acetylneuraminic acid chain, capped by an 8-O-sulfated sialic acid residue Reviewed

Miyata, S., Sato, C., Kitamura, S., Toriyama, M.,and Kitajima, K.

Glycobiology   Vol. 141   page： 827-840   2004

受精・発生と糖鎖認識の研究における最近の発展 Reviewed

北島健

生化学   Vol. 76   page： 191-200   2004

Specificity of human trans-sialidase as probed with gangliosides. Reviewed

Nikonova, E.Y., Tertov, V.V., Sato C, Kitajima K, and Bovin, N.V.

Bioorg Med Chem. Lett.   Vol. 141   page： 5161-5164   2004

Alpha-C-Mannosyltryptophan is not recognized by conventional mannose-binding lectins Reviewed

Nishikawa T, Kajii S, Sato C, Yasukawa Z, Kitajima K, and Isobe M.

Bioorg Med Chem.   Vol. 12   page： 2343-2348   2004

Surface plasmon resonance study of carbohydrate-carbohydrate interaction between various gangliosides and Gg3-carrying polystyrene Reviewed

Matsuura, K., Oda, R., Kitakouji, H., Kiso, M., Kitajima, K., and Kobayashi, K.

Biomacromolecules   Vol. 5   page： 937-941   2004

A newly identified zona pellucida glycoprotein, ZPD, and domeric ZP1 of chicken egg envelope are involved in sperm activation on sperm-egg Reviewed

Okumura, H., Khono, Y., Iwata, Y., Mori, H., Aoki, N., Sato, C., Kitajima, K., Nadano, D., and Matsuda, T.

Biochem. J.   Vol. 384   page： 191-199   2004

Developmental expression of a sialyltransferase responsible for sialylation of cortical alveolus glycoprotein during oogenesis in rainbow trout (Oncorhynchus mykiss) Reviewed

Asahina, S., Sato, C., and Kitajima, K.

J. Biochem. (Tokyo)   Vol. 136   page： 189-198   2004

"A 33-kDa allergen from rice (Oryza sativa L. Japonica). cDNA cloning, expression, and identification as a novel glyoxalase I."

"Usui, Y., Nakase, M., Hotta, H., Urisu, A., Aoki, N., Kitajima, K., and Matsuda, T."

J. Biol. Chem.   Vol. 276   page： 11376-11381   2002.2

Morphological and biochemical changes of isolated chicken egg-envelope during sperm penetration: Degradation of the 97 kilodalton glycoprotein is involved in sperm-driven hole formation on the egg-envelope.

"Takeuchi, Y., Cho, R., Iwata, Y., Nishimura, K., Kato, T., Aoki, N., Kitajima, K., and Matsuda, T."

Biology of Reproduction   Vol. 64   page： 822-830   2001.1

Molecular cloning of a unique CMP-sialic acid synthetase which effectively utilizes both deaminoneuraminic Acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates.

"Nakata, D., Munster, A.-K., Gerardy-Schahn, R., Aoki, N., Matsuda, T., and Kitajima, K."

Glycobiology   Vol. 11   page： 685-692   2001.1

"Detection of di-, oligo-, and polysialic acid in glycoproteins."

"Sato, C., Kitajima, K."

Recent Research Developments in Analytical Biochemistry   Vol. "Transworld Research Network Publisher, India"   page： in press   2001.1

Occurrence of oligosialic acids on integrin alpha-5 subunit and thier involvement in cell adhesion to fibronectin.

"Nadanaka, S., Sato, C., Kitajima, K., Katagiri, K., Irie, S., and Yamagata, T."

Journal of Biological Chemistry   Vol. 276   page： 33657-33664   2001.1

"Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q."

"Sato, C., Yasukawa, Z., Honda, N., Matsuda, T., and Kitajima, K."

Journal of Biological Chemistry   Vol. 276   page： 28849-28856   2001.1

CA15. Oligosialic acid as a differentiation-associated antigen in human haemotoietic cell line HL60. Part 4 Carbohydrate and lectin.

"Sato, C., Matsuda, T., and Kitajima, K."

"Leucocyte typing VII (Mason et al., eds)"     page： in press   2001.1

CA3. Carbohydrate-recognizing monoclonal antibodies as revealed by ELISA using phosphatidylethanolamine-conjugated oligosacharides as antigens. Part 4 Carbohydrate and lectin.

"Sato, C., Matsuda, T., and Kitajima, K."

"Leucocyte typing VII (Mason et al., eds)"     page： in press   2001.1

Carbohydrate-recognizing monoclonal antibodies as revealed by ELISA using phosphatidylethanolamine-conjugated oligosacharides as antigens.

Leucocyte typing VII (Mason et al., eds), Oxford University Press     page： in press   2001

Occurrence of oligosialic acids on integrin alpha-5 subunit and thier involvement in cell adhesion to fibronectin.

J. Biol. Chem.   Vol. 276   page： 33657-33664   2001

Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q.

J. Biol. Chem.   Vol. 276   page： 28849-28856   2001

Molecular cloning of a unique CMP-sialic acid synthetase which effectively utilizes both deaminoneuraminic acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates

Glycobiology   Vol. 11   page： 685-692   2001

Detection of di-, oligo-, and polysialic acid in glycoproteins.

Recent Research Developments in Analytical Biochemistry     page： in press   2001

Oligosialic acid as a differentiation-associated antigen in human haemotoietic cell line HL60.

Leucocyte typing VII (Mason et al., eds), Oxford University Press     page： in press   2001

Morphological and biochemical changes of isolated chicken egg-envelope during sperm penetration: Degradation of the 97 kilodalton glycoprotein is involved in sperm-driven hole formation on the egg-envelope.

Biol. Reprod.   Vol. 64   page： 822-830   2001

"Co-localization of receptor and transducer proteins in the glycosphingolipid-enriched, low density, detergent-insoluble membrane fraction of sea urchin sperm."

"Ohta, K., Sato, C., Matsuda, T., Toriyama, M., Vacquier, V. D., Lennarz, W. J., and Kitajima, K."

Glycoconjugate Journal   Vol. 17   page： 205-214   2000.1

"Frequent occurrence of pre-existing alpha2,8-linked disialic and oligosialic acids with chain lengths up to 7 Sia residues in mammalian brain glycoproteins. Prevalence revealed by highly sensitive chemical methods and anti-di-, oligo, and polysialic acid antibodies specific for defined chain lengths."

"Sato, C., Fukuoka, H., Ohta, K., Matsuda, T., Koshino, R., Kobayashi, K., Troy, F. A. II,, and Kitajima, K."

Journal of Biological Chemistry   Vol. 275   page： 15422-15431   2000.1

Lipid raft on gametic cells as a functional domain for sperm-egg interaction coupled with signal transduction.

"Ohta, K., Sato, C., Matsuda, T., Toriyama, M., Vacquier, V. D., Hirohashi, N., Lennarz, W. J., and Kitajima, K."

Zygote   Vol. 8 (Suppliment)   page： S56   2000.1

Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which has not the deaminoneuraminic acid (KDN) 9-phosphate synthase activity.

"Nakata, D., Close, B. E., Colley, K. J., Matsuda, T., and Kitajima, K."

Biochemical and Biophysical Research Communication   Vol. 273   page： 642-648   2000.1

細胞間接着における糖鎖-糖鎖相互作用

北島健

"季刊「化学総説」季刊「化学総説」No. 48「糖鎖分子の設計と生理機能」日本化学会編,学会出版センター,pp.199-207"   Vol. "48「糖鎖分子の設計と生理機能」日本化学会編,学会出版センター"   page： pp.199-207   2000.1

Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which has not the deaminoneuraminic acid (KDN) 9-phosphate synthase activity.

Biochem. Biophys. Res. Commun.   Vol. 273 ( 2 ) page： 642-648   2000

Lipid raft on gametic cells as a functional domain for sperm-egg interaction coupled with signal transduction.

Zygote   Vol. 8   page： S56   2000

Co-localization of receptor and transducer proteins in the glycosphingolipid-enriched, low density, detergent-insoluble membrane fraction of sea urchin sperm.

Glycoconjugate Journal   Vol. 17   page： 205-214   2000

Frequent occurrence of pre-existing alpha-2,8-linked disialic and oligosialic acids with chain lengths up to 7 Sia residues in mammalian brain glycoproteins: Prevalence revealed by highly sensitive chemical methods and anti-di-, oligo, and polysialic acid antibodies specific for defined chain lengths.

J. Biol. Chem.   Vol. 275   page： 15422-15431   2000

細胞間接着における糖鎖-糖鎖相互作用

季刊化学総説「糖鎖分子の設計と生理機能」   Vol. 48   page： 199-207   2000

"A 42-kDa glycoprotein from chicken egg-envelope, an avian homolog of the ZPC family glycoproteins in mammalian zona pellucida. Its first identification, cDNA cloning and granulosa cell-specific expression."

"Takeuchi, T., Nishimura, K., Aoki, N., Adachi, T., Sato, C., Kitajima, K., and Matsuda, T."

European Journal of Biochemistry   Vol. 273   page： 21526-21530   1999.1

Glycobiology of di and oligosialyl glycotopes.

"Sato, C., and Kitajima, K."

Trends in Glycoscience Glycotechnology   Vol. 11   page： 371-390   1999.1

Cholesterol-dependent localization of NAP-22 on a neuronal membrane microdomain (Raft).

"Maekawa, S., Sato, C., Kitajima, K., Kumanogoh, H., Funatsu, N., and Sokawa, Y."

Journal of Biological Chemistry Biological   Vol. 274   page： 21369-21374   1999.1

Isolation and characterization of low density detergent-insoluble membrane (LD-DIM) fraction from sea urchin sperm.

"Ohta, K., Sato, C., Matsuda, T., Toriyama, M., Lennarz W. J., and Kitajima, K."

Biochemical and Biophysical Research Communication   Vol. 258   page： 616-623   1999.1

Lactation-dependent expression of an mRNA splice variant with an exon for a multiply O-glycosylated domain of mouse milk fat glubule glycoprotein MFG-E8.

"Oshima, K., Aoki, N., Negi, M., Kishi, M., Kitajima, K., and Matsuda, T."

Biochemical and Biophysical Research Communication   Vol. 254   page： 522-528   1999.1

Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and Characterization of a KDN-9-phosphate Synthetase Activity from Trout Testis.

"Angata, T., Nakata, D., Matsuda, T., Kitajima, K., and Troy, F. A. II"

Journal of Biological Chemistry   Vol. 274   page： 22949-22956   1999.1

Identification of two discrete peptide:N-glycanases in Oryzias latipes during embryogenesis.

"Seko, A., Kitajima, K., Iwamatsu, T., Inoue, S., and Inoue, Y."

Glycobiology   Vol. 9   page： 887-895   1999.1

Elevated expression of free deaminoneuraminic in mammalian cells cultured in mannose-rich media.

"Angata, T., Nakata, D., Matsuda, T., and Kitajima, K."

Biochemical and Biophysical Research Communication   Vol. 261   page： 326-331   1999.1

Fluorescent-assisted detection of oligosialyl units glycoconjugates.

"Sato, C., Inoue, S., Matsuda, T., and Kitajima, K.,"

Analytical Biochemistry   Vol. 266   page： 102-109   1999.1

Fluorescent-assisted detection of oligosialyl units in glycoconjugates.

"Sato, C., Inoue, S., Matsuda, T., and Kitajima, K."

Analytical Biochemistry   Vol. 267   page： 102-109   1999.1

Occurrence of a2ョ8-linked oligosialic acid residues in mammalian glycoproteins.

"Kitajima, K., Sato, C., Honda, N., Matsuda, T., Yokoyama, M.-H., Close, B. E., and Colley, K. J."

Sialobiology and Other novel Form of Glycosylation   Vol. "a monograph (Inoue, Y., Lee, Y. C., and Troy, F. A., eds), , Gakushin Syuppan, Osaka, Japan"   page： pp.69-76   1999.1

Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis.

J. Biol. Chem.   Vol. 274   page： 22949-22956   1999

Lactation-dependent expression of an mRNA splice variant with an exon for a multiply O-glycosylated domain of mouse milk fat glubule glycoprotein MFG-E8.

Biochem. Biophys. Res. Commun.   Vol. 254   page： 522-528   1999

Cholesterol-dependent localization of NAP-22 on a neuronal membrane microdomain (Raft).

J. Biol. Chem.   Vol. 274   page： 21369-21374   1999

Identification of two discrete peptide:N-glycanases in Oryzias latipes during embryogenesis.

Glycobiology   Vol. 9   page： 887-895   1999

Elevated expression of free deaminoneuraminic in mammalian cells cultured in mannose-rich media.

Biochem. Biophys. Res. Commun.   Vol. 261   page： 326-331   1999

Fluorescent-assisted detection of oligosialyl units in glycoconjugates.

Analytical Biochemistry   Vol. 266   page： 102-109   1999

Glycobiology of di and oligosialyl glycotopes.

Trends Glycosci. Glycotechnol.   Vol. 11   page： 371-390   1999

Isolation and characterization of low density detergent-insoluble membrane (LD-DIM) fraction from sea urchin sperm.

Biochem. Biophys. Res. Commun.   Vol. 258   page： 616-623   1999

A 42-kDa glycoprotein from chicken egg-envelope, an avian homolog of the ZPC family glycoproteins in mammalian zona pellucida. Its first identification, cDNA cloning and granulosa cell-specific expression.

Eur. J. Biochem.   Vol. 273   page： 21526-21530   1999

A method for determination of UDP-GlcNAc: GlcNAcβ1-6(GlcNAcβ1-2)Man1-R[GlcNAc to Man] β1-4N-acetylglucosaminyl transferase VI activity using a pyridylaminated tetraantennary oligosaccharide as an acceptor substrate.

"Taguchi, T., Ogawa, T., Kitajima, K., Inoue, S., Inoue, Y., Ihara, Y., Sakamoto, Y., Nagai, K., and Taniguchi, N.,"

Analytical Biochemistry   Vol. 255   page： 155-157   1998.1

"Cloning a expression of an α-2,8-polysialyltransferase (STX) from Xenopus laevis."

"Kudo, M., Takayama, E., Tashiro, K., Fukamachi, H., Nakata, T., Tadakuma, T., Kitajima, K., Inoue, Y., and Shiokawa, K.,"

Glycobiology   Vol. 8   page： 771-777   1998.1

Avian egg coat glycoproteins: identification and characterization of homologues of mammalian zona pellucida glycoproteins.

"Matsuda, T., Nishimura, K., Tsuda, T., Takeuchi, Y., Adachi, T., Aoki, N., and Kitajima, K."

Zygote   Vol. 6   page： S80-S81   1998.1

Development of an enzyme-linked immunoadsorbent assay- based method for measuring galactosyltransferase activity using a synthetic glycopolymer acceptor substrate.

"Oubihi, M., Kitajima, K., Kobayashi, K., Adachi, T., Aoki, N., and Matsuda, T.,"

Analytical Biochemistry   Vol. 257   page： 169-175   1998.1

"Iuction of KDNase Sm, a deaminoneuraminic acid (KDN) residue-specific sialidase from Sphingobacterium multivorum, using synthetic KDN-glycosides."

"Fuchizawa, S., Furuhata, K., Matsuda, T., and Kitajima, K.,"

Biochemical and Biophysical Research Communication   Vol. 248   page： 505-510   1998.1

Peptides glycosylated in the eoplasmic reticulum of yeast are subsequently deglycosylated by a soluble peptide N-glycanase activity.

"Suzuki, T., Park, H., Kitajima, K., and Lennarz, W. J.,"

Jorunal of Biological Chemistry   Vol. 273   page： 21526-21530   1998.1

"Development of a highly sensitive chemical method to detect α-2,8-linked oligo/polysialic acid residues in glycoproteins blotted on the membrane."

"Sato, C., Inoue, S., Matsuda, T., and Kitajima, K.,"

Anal. Biochemistry   Vol. 261   page： 191-197   1998.1

Identification of oligo-N-glycolylneuraminic acid residues in mammal-derived glycoproteins by a newly developed immunochemical reagent a biochemical methods.

"Sato, C., Kitajima, K., Inoue, S., and Inoue, Y.,"

Jounal of Biological Chemistry   Vol. 273   page： 2575-2582   1998.1

"Synthesis of neoglycoconjugates containing deaminated neuraminic acid (KDN) using rat liver α2,6-sialyltransferase."

"Angata, T., Matsuda, T., and Kitajima, K.,"

Glycobiology   Vol. 8   page： 277-284   1998.1

新しいシアル酸KDNの糖鎖科学の現状と展望

北島健

バイオサイエンスとインダストリー   Vol. 56   page： 659-664   1998.1

"Structure and physiological activities of hyosophorin, a major cortical alveolus glycoprotein of fish eggs."

"Kitajima, K., Taniguchi, J., Nakase, M., Kageyama, M., Matsuda, T., Sakagami, H., Inoue, S., and Inoue, Y."

Zygote   Vol. 6   page： S6-S7   1998.1

Identification of oligo-N-glycolylneuraminic acid residues mammal-derived glycoproteins by a newly developed immunochemical reagent and biochemical methods.

J. Biol. Chem   Vol. 273   page： 2575-2582   1998

Synthesis of neoglycoconjugates containing deaminated neuraminic acid(KDN)using rat liver α2,6-sialytransferase.

Glycobiology   Vol. 8   page： 277-284   1998

Peptides glycosylated in the endoplasmic reticulum of yeast are subsequently deglycosylated by a soluble peptide : N-glycanase activity.

J. Biol. Chem. ,   Vol. 273   page： 21526-21530   1998

Structure and physiological activities of hyosophorin, a major cortical alveolus glycoprotein of fish eggs.

Zygote   Vol. 6   page： S6-S7   1998

Induction of KDNase Sm, a deaminoneuraminic acid(KDN)residue-specific sialidase from Sphingobacterium multivorum, using synthetic KDN-glycosides.

Biochem. Biophys. Res. Commun.   Vol. 248   page： 505-510   1998

動物細胞におけるデアミノノイラミン酸(KDN)の生合成経路およびKDN複合糖質の発現の調節機構の解析

生化学   Vol. 70   page： 607   1998

Avian egg coat glycoproteins : identification and characterzation of homologues of mammalian zona pellucida glycoproteins.

Zygote   Vol. 6   page： S80-S81   1998

Present status and perspectives in research on a novel sialic acid, KDN.

Bioscience and Industry   Vol. 56   page： 659-664   1998

Development of an enzyme-linked immunosorbent assay(ELISA)-based method for measuring galactosyltrasferase activity using a synthetic glycopolymer acceptor substrate.

Anal. Biochem. ,   Vol. 257   page： 169-175   1998

A method for determination of UDP-Glc NAc : GlcNAcβ1-6(GlcNAc(β1-2)Manα1-R[GlcNAc to Man]β 1-4 N-acetylglucosaminyltransferase (]G0006[) activity using a pyridylaminated tetraantennary oligosaccharide as an acceptor substrate.

Anal. Biochem. ,   Vol. 255   page： 155-157   1998

Cloning and expression of an α2,8-polysialyltransferase(STX)from Xenopus aevis.

Glycobiology   Vol. 8   page： 771-777   1998

Development of a highly sensitive chemical method to detect α2→8-linked oligo/polysialic acid residues in glycoproteins blotted on the membrane.

Anal. Biochem.   Vol. 261   page： 191-197   1998

Activity of UDP-GlcNAc: GlcNAcβ1-6(GlcNAcβ1-2)Man1-R[GlcNAc to Man]β1-4-N-acetyl glucosaminyl transferase VI(GnT VI) from the ovaries of Oryzias latipes (Medaka fish).

"Taguchi, T., Kitajima, K., Inoue, S., Inoue, Y., Yang, J.-M., Schachter, H., and Brockhausen, I.,"

Biochemical and Biophysical Research Communication   Vol. 230   page： 533-536   1997.1

"Occurrence of terminal α2,8-linked disialylated poly-N-acetyllactosamine chains with Le^X a I antigenic glycotopes in tetraantennary arms of an N-linked glycoprotein isolated from rainbow trout ovarian fluid."

"Funakoshi, Y., Taguchi, Y., Sato, C., Kitajima, K., Inoue, S., Morris, H. R., Dell, A., and Inoue, Y.,"

Glycobiology   Vol. 7   page： 195-205   1997.1

Combined chemical a enzymatic synthesis of a C-glycopeptide a its inhibitory activity toward glycosaminidases.

"Wang, L.-X., Tang, M., Suzuki, T., Kitajima, K., Inoue, Y., Inoue, S., Fan, J.-Q., and Lee, Y. C.,"

Jorunal of American Chemical Society   Vol. 119   page： 11137-11146   1997.1

"Catalysis by a new sialidase, deaminoneuraminic acid residue-cleaving enzyme (KDNase Sm), initially forms a less stable α-anomer of 3-deoxy-D-glycero-D-galacto-nononic acid a is strongly inhibited by the transition state analogue, 2-deoxy-2,3-dide hydro-D-glycero-D-galacto-2-nonulosonic acid, but not by 2-deoxy-2,3-didehydro-N-acetylneuraminic acid."

"Terada, T., Kitajima, K., Inoue, S., Wilson, J. C., Norton, A. K., Kong, D. C. M., Thomson, R. J., von Itzstein, M., and Inoue, Y.,"

Jornal of Biological Chemistry   Vol. 272   page： 5452-5456   1997.1

KDN：ユニークなシアル酸の世界(Recent Advances in KDN Glycoscience)

北島健

バイオインダストリー   Vol. 14   page： 11-21   1997.1

"Proton NMR study of triantennary complex type N-linked glycan chains: assignment of protein chemical shifts of the β-Man residue in a basic unit of the triantennary glycan chain having a GlcNAcβ1,6Manα1,6Manβ1-sequence."

"Taguchi, T., Muto, Y., Kitajima, K., Yokoyama, S., Inoue, S., and Inoue, Y.,"

Glycobiology   Vol. 7   page： 31-36   1997.1

Site-sepcific de-N-glycosylation of diglycosylated ovalbumin in hen oviduct by eogenous peptide: N-glycanase as a quality control system for newly synthesized proteins.

"Suzuki, T., Kitajima, K., Emori, Y., Inoue, Y., and Inoue, S.,"

Proc. Natl. Acad. Sci. USA   Vol. 94   page： 6244-6249   1997.1

新しいシアル酸KDNの糖鎖生物学の最近の発展(Recent advances in glycobiology on KDN-containing glycoconjugates)

北島健、井上貞子、井上康男

生化学   Vol. 68   page： 44-51   1997.1

Recent advances in glycobiology on KDN-containing alycoconjugates(共著)

Seikagaku   Vol. 69 ( 1 ) page： 44-51   1997

糖タンパク質における新しいシアル酸含有糖鎖構造とその機能

日本農芸化学会誌   Vol. 72   page： 452   1997

Catalysis by a new sialidase, deaminoneuraminic acid residue-cleaving enzyme(KDNase Sm), initially forms a less stable α-arromer of KDN and is strongly in kibited by the transition-state analogue, KDN2en, but not Neu5 Ac2en. (共著)

The Journal of Biological Chemistry   Vol. 272 ( 9 ) page： 5452-5456   1997

Activity of UDP-GlcNAc : GlcNAcβ1→6(GlcNAcβ1→2)Man α1→R[GlcNAc to Man]β1→4N-acetylglucosaminyl-transferase Vl(GnT Vl)from The ouaries of Oryzias latibes(Medake fish)(共著)

Biochem. Biophys. Res. Commun.   Vol. 230   page： 533-536   1997

Proton NMR study of triantennary complex type N-linked glycan chains : assignment of proton chemical shifts of the β-Man residue in a basic unit of the triantennary glycan chain having a GlcNAc β1→6Man α1→6Man β→Sequence(共著)

Glycobiology   Vol. 7 ( 1 ) page： 31-36   1997

Site-specific de-N-glycosylation of diglycosylated ovalbumin in hen oviduct byendogenous PNG ase as a quality control systemfor newly synthesized proteins(共著)

Proc. National Academy of Science   Vol. 94   page： 6244-6249   1997

Recent advances in KDN glycosciences

  Vol. 14 ( 8 ) page： 11-21   1997

"Characterization of the major core structures of the α2,8-linked polysialic acid-containing glycan chains present in neural cell adhesion molecule (N-CAM) in embryonic chick brains."

"Kudo, M., Kitajima, K., Inoue, S., Shiokawa, K., Morris, H. R., Dell, A., and Inoue, Y.,"

Jorunal of Biological Chemistry   Vol. 271   page： 326667-32677   1996.1

"Occurrence of poly α2,8 deaminoneuraminic acid (KDN) in mammalian tissues: Widespread a developmentally-regulated but highly selective expression on glycoproteins."

"Ziak, M., Qu, B., Zuo, X., Zuber, C., Kanamori, A., Kitajima, K., Inoue, S., Inoue, Y., and Roth, J.,"

Proc. Natl. Acad. Sci. U.S.A.   Vol. 93   page： 2759-2763   1996.1

"Iuction, localization, a purification of a novel sialidase, deaminoneuraminidase (KDNase), from Sphingobacterium multivorum."

"Nishino, S., Kuroyanagi, H., Terada, T., Inoue, S., Inoue, Y., Troy, F. A., II, and Kitajima, K.,"

Journal of Biological Chemistry   Vol. 271   page： 2909-2913   1996.1

"The occurrence of novel 9-O-sulfated N-glycolylneuraminic acid-cappedα2,5-O_glycolyl-linked oligo/polyNeu5Gc chains in sea urchin egg cell surface glycoprotein. Identification of a new chain termination signal for polysialyltransferase."

"Kitazume, S., Kitajima, K., Inoue, S., Haslam, S. M., Morris, H. R., Dell, A., Lennarz, W. J., and Inoue, Y.,"

Jornal of Biological Chemistry   Vol. 271   page： 6694-6701   1996.1

Occurrence a precise structural analysis of highly sulfated multiantennary N-linked glycan chains derived from a fertilization-associated carbohydrate-rich glycoprotein in unfertilized eggs of Tribolodon hakonensis.

"Taguchi, T., Iwasaki, M., Muto, Y., Kitajima, K., Inoue, S., Khoo, K.-H., Morris, H. R., Dell, A., and Inoue, Y.,"

European Jornal of Biochemistry   Vol. 238   page： 357-367   1996.1

Isolation a identification of novel sulfated a nonsulfated oligosialyl glycosphingolipids from sea urchin sperm.

"Ijuin, T., Kitajima, K., Yu, S., Kitazume, S., Inoue, A., Haslam, S. M., Morris, H. R., Dell, A., and Inoue, Y.,"

Glycoconjugate Journal   Vol. 13   page： 401-413   1996.1

Structure and function of N-glycosylated glycoprotein in fish eggs and embryos.

"Kitajima, K."

Nippon Suisan Gakkaishi   Vol. 62   page： 289-290   1996.1

Substrate specificity of rainbow trout testis CMP-KDN synthetase. Kinetic studies of the CMP-KDN synthetase-catalyzed reaction of natural a synthetic analogues of nonulosonic acid.

"Terada, T., Kitajima, K., Inoue, S., Koppert, K., Brossmer, R., and Inoue, R.,"

European Journal of Biochemistry   Vol. 236   page： 852-855   1996.1

"Identification of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN, deaminoneuraminic acid) residues in mammalian tissues a human lung carcinoma cells. Chemical evidence of the occurrence of KDN glycoconjugates in mammals."

"Inoue, S., Kitajima, K., and Inoue, Y.,"

Journal of Biological Chemistry   Vol. 271   page： 24341-24344   1996.1

Identification of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid(KDN, deaminoneuraminic acid)residues in mammalian tissues and human lung carcinoma cells. (共著)

The Journal of Biological Chemistry   Vol. 271 ( 40 ) page： 24341-24344   1996

Induction, localization, and purification of a novel sialidase, deaminoneuraminidase (KDNase), from Sphingobocteriun multivorum.

The Journal of Biological chemistry   Vol. 271 ( 6 ) page： 2909-2913   1996

Structure and function of N-glycosylatecl glycoprotein in fish eggs and embryos.

Nippon Suisan Gakkaishi   Vol. 62 ( 2 ) page： 289-290   1996

The occurrence of novel 9-O-Sulfated N-glycolylneuraminic acid-capped α2→5-Oglycolyl-limked oligo/poly Neu5Gc chains in Sea urchin egg cell surface glycoprotein. Identification of a new chain termination signal for polysialyltransferse.(共著)

The Journal of Biological Chemistry   Vol. 271 ( 12 ) page： 6694-6701   1996

Characterization of the major core structures of the α2→8-linked polysialic acid-containing glycan chains present in neural cell adhesion molecule in embryonic chick brains. (共著)

The Journal of Biological Chemistry   Vol. 271 ( 51 ) page： 32667-32677   1996

Isolation and identification of novel sulfated and nonsulfated oligosialyl glycosphingolipids from sea urchin sperm.

Glycoconjugate Journal   Vol. 13 ( 3 ) page： 401-413   1996

Substrate specificity of rainbow trout testis CMP-3-deoxy-D-glycero-D-galaeto-noncelosonic acicl (CMP-Kdn) synthe tase. Kinetic studies of the reaction of natural and synthetic analogues of ncnulosonic acid catalyzed by CMP-Kdn syuthefase.(共著)

European Journal of Biochemistry   Vol. 236   page： 852-855   1996

Occurrence of poly(α2,8-deamino neuraminic acid) in mammalian tissues: widespread and developmentally regulated but highly selective expression on glycoprotoins.(共著)

Proclaim of National Academy of Science, U.S.A.   Vol. 93   page： 2759-2763   1996

Occurrence and structural analysis of highly sulfated multiantennary N-lmked glycan chains derived from a fertilization-associated carbohydrate-rich glycoprotein in unfertilized eggs of Tribolodon hakonensis. (共著)

European Journal of Biochemistry   Vol. 238   page： 357-367   1996

Expression of new KDN-gangliosides in rainbow trout testis during spermatogenesis a their structural identification.

"Yu, S., Kitajima, K., Inoue, S., Khoo, K.-H., Morris, H. R., Dell, A., and Inoue, Y.,"

Glycobiology   Vol. 5   page： 207-218   1995.1

Complete assignment of carbon-13 NMR resonances to all the carbon atoms of the trimannosido-di-N-acetylchitobiosyl structure in a pentaantennary decasaccharide glycopeptide.

"Taguchi, T., Kitajima, K., Niimi, T., Muto, Y., Yokoyama, S., Inoue, S., and Inoue, Y.,"

Carbohydr. Res.   Vol. 275   page： 185-191   1995.1

A precise structural analysis of a fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of euryhaline killi fish (Fuulus heteroclitus). Novel pentaantennary N-glycan chains with a bisecting N-acetylglucosaminyl residue.

"Taguchi, T., Kitajima, K., Muto, T., Inoue, S., Khoo, K.-H., Morris, H. R., Dell, A., Wallace, R. A., Selman, K., and Inoue, Y.,"

Glycobiology   Vol. 5   page： 611-624   1995.1

N-Glycosylation/deglycosylation as a mechanism for the post-translational modification/remodification of proteins.

"Suzuki, T., Kitajima, K., Inoue, S., and Inoue, Y.,"

Glycoconjugate Journal   Vol. 12   page： 183-193   1995.1

Proton NMR study of the trimannosyl unit in a pentaantennary N-linked decasaccharide structure. Complete assignment of the proton resonances a conformational characterization.

"Taguchi, T., Kitajima, K., Muto, Y., Yokoyama, S., Inoue, S., and Inoue, Y.,"

European Jornal of Biochemistry   Vol. 288   page： 822-829   1995.1

"Characterization of the antigenic specificity of four different anti-(α2,8-linked polysialic acid) antibodies using lipid-conjugated oligo/polysialic acids."

"Sato, C., Kitajima, K., Inoue, S., Seki, T., Troy, F. A., II, and Inoue, Y.,"

Journal of Biological Chemistry   Vol. 270   page： 18923-18928   1995.1

Identification a distribution of peptide: N-glycanase (PNGase) in mouse organ.

"Kitajima, K., Suzuki, T., Kouchi, Z., Inoue, S., and Inoue, Y.,"

Arch. Biochem. Biophys.   Vol. 319   page： 393-401   1995.1

Carbohydrate-biing property of peptide: N-glycanase (PNGase) from mouse fibroblast L-929 cells as evaluated by inhibition a biing experiments using various oligosaccharides.

"Suzuki, T., Kitajima, K., Inoue, S., and Inoue, Y.,"

Journal of Biological Chemistry   Vol. 270   page： 15181-15186   1995.1

A precise structural analysis of a fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of euryhaline killi fish (Fundulus heteroclitus). Novel qenta-antennary N-glycar chains coith a bisecting N-acetylqlucosampyl residel,

Glycobiology   Vol. 5 ( 6 ) page： 611-624   1995

Proton NMR study of the triomannosyl unit in a pentaanternary N-linked decasaccharide structure (共著)

European Journal of Biochemistry   Vol. 228   page： 822-829   1995

Complete assignments of ^BC NMR resonance to all the carbon atoms of the trimannosido-di-N-acetylchitobiosyl structure in a pentaantennary decusaccharide glycopepticle.(共著)

Carbohyclrate Researoh   Vol. 275   page： 185-191   1995

I dentification and distribution of peptide: N-glycanase (PNGose) in mouse organs.

Archives of Biochemistry and Bioplcysics   Vol. 319 ( 2 ) page： 393-401   1995

Carbohydrate-binding property of peptide: N-glyecanase from mouse fibroblast L-929 cells as evaluated by inhibition and binding experiments using various oligosaccharides.

The Journal of Biological Chemistry   Vol. 270 ( 25 ) page： 15181-15186   1995

Characterization of the antigenic specificity of four different anti(α2→8-linked polysialit acid) antibodies using lipid- conjugated oligo/polysialic acids.(共著)

The Journal of Biologicol chemistry   Vol. 270 ( 32 ) page： 18923-18928   1995

N-Glycosylation/deglycosylation as a mechanism for the post-translational modification/remodification of proteins(共著)

Glycoconjugate Journal   Vol. 12 ( 1 ) page： 183-193   1995

Expression of new KDN-gangliosides in rainbow trout testis during spermatogenesis and their structural identification (共著)

Glycobiology   Vol. 5 ( 2 ) page： 207-218   1995

Discovery of a New type of sialidase, "KDN ase, " which specifically hydrolyzes deamironeuraminyl (3-deoxy-D-glycero-D-galacto-2-nonulosonic acid) but not N-acylneuraminyl linkages

The Journal of Biological Chemistry   Vol. 269 ( 34 ) page： 21415-21419   1994

Occurrence and biological roles of 'proximal glycanases' in animal cells (共著)

Glycobiology   Vol. 4 ( 6 ) page： 777-789   1994

Calcium ion binding of three different types of oligo/polysialic acids as studied by equilibrium dialysis and circular dichroic methods (共著)

Biochemistry   Vol. 33 ( 5 ) page： 1202-1208   1994

Differential reactivity of two types of N-ghycolylneuraminic acid dimers toward enzymatic and nonenzymatic hydrolysis of their interketosidic linkages (共著)

Biochemical and Biophysical Research Communication   Vol. 205 ( 1 ) page： 893-898   1994

Identification, characterization, and developmental Expression of a novel α2→8-KDN-transferase which terminates elongation of α2→8-linked oligo-polgsialic acid chain synthesis in trout egg polysialoglycoproteins (共著)

Glycoconjugate Journal   Vol. 11   page： 493-499   1994

Does an animal peptide : N-glycanase have the dual role as an enzyme and a carbohydrate-binding protein ? (共著)

Glycoconjugate Journal   Vol. 11   page： 469-476   1994

Purification and enzymatic properties of peptide : N-glycanase from C3H mouse-derived L-929 fibroblast cells. (共著)

The Journal of Biological Chemistry   Vol. 269 ( 26 ) page： 17611-17618   1994

Isolation, structural determination, and calcium-binding properties of the major glycoprotein present in Bufo Japouicus japonicus egg jelly (共著)

European Journal of Biochemistry   Vol. 223   page： 223-231   1994

Identification of polysialic acids in glycoconjugates (共著)

Methods in Enzymology   Vol. 230   page： 460-484   1994

Identification, developmental expression and tissue distribution of deaminonouraminate hydrolase (KDNase) activity in rainbow trout (共著)

Glycobiology   Vol. 4 ( 4 ) page： 517-523   1994

Developmental Expression of trout egg poly sialogly coproteis and the preroquisite α2,6-, and α2,8-sialyl and α2,8-poly-sialyltransferase activities required for their synthesis during oogenesis (共著)

The Journal of Biological Chemistry   Vol. 269 ( 14 ) page： 10330-10340   1994

Identification and structural determination of the KDN-containing N-linked glycan chains consisting of bi-and tri-dntennary complex-type units of KDN-glycoprotin previously isolated from rainbow trout vitelline envelopes (共著)

Biochemistry   Vol. 33 ( 21 ) page： 6495-6502   1994

Identification of polysialic acid-containing glyroprotein in the jelly coat of sea urchin eggs. (共著)

The Journal of Biological Chuistry   Vol. 269 ( 36 ) page： 22712-22718   1994

Structural studies of a novel type of penta artennary large glycan unit in the fertilization-associated carbohydraterich glycopeptide isolated from the fertilized eggs of Oryzias latipes (共著)

The Journal of Biological Chemistry   Vol. 269 ( 12 ) page： 8762-8771   1994

Monoclonal antibody speatic for α2→8-linked olrgo dominated neuraminic acid (KDN) sequeuces in glycoproteins. Preparation and characterization of a manoclonal antibody and its application in immunohistochemistry (共著)

Histochemistry   Vol. 101 ( 5 ) page： 333-340   1994

CMP-3-Deoxynonulosonate Synthetase which Catalyzes the Transfer of CMP to KDN from CTP : Partial Purification and Characterization of the Enzyme from Rainbow trout testis. (共著)

Polysiolic Acid, Birkh(]J1103[)user-Verlag Basel, Switzerland     page： 191-199   1993

Immunochemical Method as Early Diagnosis for Distinguishing Salmonid Fish Female and Male Prior to Genital Maturation by use of a Minute Amount of Blood Collected from a Single Piece of Gill Filament (共著)

Nippon Suisan Gakkaishi   Vol. 59 ( 4 ) page： 593-600   1993

Monoclonal Antibody Specific to α-2→3-Linked Deaminated Neuraminyl β-Galactosyl Sequence (共著)

Glycobiology   Vol. 3   page： 31-36   1993

Synthesis of CMP-Deaminoneuraminic Acid (CMP-KDN) Usig the CTP : CMP-3-Deoxynonulosonate Cytidylyl-transferase from rainbow trout testis. (共著)

The Journal of Biological Chemistry   Vol. 268   page： 2640-2648   1993

Analytical methods for identifying and quantitating poly (α2→8 Sia) structures containing Neu5Ac, Neu5Gc, and KDN.(共著)

Polysialic acid, Birkh〓user-Verlag, Basel, 5witzerland     page： 183-189   1993

Structure studies of a novel type of tetraantennary sialoglycan unit in a carbohydrate-rich glycopeptide isolated from the fertilized eggs of Indian medaka fish, Oryzias melastigma (共著)

The Journal of Biological Chemistry   Vol. 268   page： 2353-2362   1993

Identification of peptide : N-glycanase activity in mammalian-derived cultured cells (共著)

Biochemical and Biophysical Research Communication   Vol. 194 ( 3 ) page： 1124-1130   1993

Structural diversity in the α2→8-linked polysiolic acid chains in Solmonid fish egg glycoproteins. (共著)

The Journal Biological Chemistry   Vol. 268   page： 23675-23684   1993

Structure of novel gangliosides, deaminated neurominic acid (KDN)-containing glycosphingolipids, isolated from rainbow trout ovarian fluid (共著)

Biochemistry   ( 32 ) page： 9221-9229   1993

Analytical Methods for Identifying and Quantitating Deamidated Sialic Acid and α2→8-Linked Poly(Oligo)nonulosonate Residues in Glycoconjugates

Analytical Biochemistry   Vol. 205   page： 244-250   1992

KDN : A novel scelit acid analogue

Protein, nucleic acid and enzyme   Vol. 37 ( 11 ) page： 1976-1981   1992

Detection, isolation, and characterization of oligo/poly(sialic acid) and oligo/poly (deamino-niuraminic acid) units in glycoconjugates (共著)

Analytical Biochemistry   Vol. 202   page： 25-34   1992

Fish egg glycophosphoproteins have species-specific N-linked glycan units previously found in a storage pool of free glycan chains (共著)

The Journal of Biological Chemistry   Vol. 267 ( 34 ) page： 24287-24296   1992

Peptide : N-glycanase activity found in the early embryos of Oryzias latipes (Medaka fish) (共著)

The Journal of Biological Chemistry   Vol. 266 ( 33 ) page： 22110-22114   1991

Isolation and structural elucidation of a novel type of ganglioside, deaminated neuraminic acid (KDN)-containing glycosphingolipid, from rainbow trout sperm. The first example of the natural occurrence of KDN-ganglioside, (KDN)GM3.(共著)

The Journal of Biological Chemistry   Vol. 266 ( 22 ) page： 21929-21935   1991

Identification of rainbow traet of delayed maturity(3-yera-maturation) based on cortical alveolar glycopooteins (hyosophorin).

Nippon Suisan Gakkaishi   Vol. 57 ( 7 ) page： 1355-1364   1991

Identification of free glycan chain liberated by de-N-glycosylation of the cortical alveolar glycoprotein (hyosophorin) during early embryogenesis of the medaka fish, Oryzias latipes.(共著)

Biochemical and Biophysical Research Communication   Vol. 180 ( 3 ) page： 1165-1171   1991

Structure and Biological Function of Cortical Alveolus Glycoprotein(hyosophorin)

  Vol. 7 ( 3 ) page： 125-132   1990

New tandem-repeating peptide structures in pulysialo-ghycoproteins from the unfertilized eggs of kokanee salmon.(共著)

Archives of Biochemistry and Biophysics   Vol. 283 ( 1 ) page： 167-172   1990

Deaminated neuraminic acid-rich glycoprotein of rainbow trout egg vitelline envelope. Occurrence of a novel α-2,8-linked oligo(deaminated neuraminic acid) structure in O-linked glycan chains.(共著)

The Journal of Biological chemistry   Vol. 265 ( 35 ) page： 21811-21819   1990

Isolation and structures of glycoprotein-derived free sialooligosaccharide from the unfertilized eggs of Tribolodon hakonensis, a dace. Intracellular accumulation of a novel class of biantennary disialooligosaccharides.(共著)

The Journal of Biological Chemistry   Vol. 264   page： 18520-18526   1989

Structural Studies of Fertilization-associated Carbohydrate-rich Glycoproteins(Hyosophorin) Isolated from the Fertilized and Unfertilized Eggs of Flounder, Parolichthys olivaceus.

The Journal of Biological Chemistry   Vol. 264 ( 27 ) page： 15922-15929   1989

Isolation and Characterization of a Novel Type of Sialoglycoproteins(Hyosophorin)from the Egg of Medaka, Oryzias latipes : Nonapeptide with a Large N-Linked Glycan Chainasa Tandem Repeat Unit

Developmental Biology   Vol. 132   page： 544-553   1989

Isolation and characterization of cleaminated neuraminic acid-rich glycoprotein (KDN-gp-OF) in the ovarian fluid of rainbow trout.(共著)

Biochemical and Birophysical Research Communication   Vol. 164   page： 1744-1749   1989

Mitogenic activity of pine cone extracts against cultured splenocyta from normal and tumor-bearing animals.(共著)

Anticancer Research   Vol. 9   page： 961-966   1989

Inhibition of herpes simplex virus infection by tannins and related compounds.(共著)

Antiviral Research   Vol. 11   page： 285-298   1989

Molecular Cloning and Characterization of cDNAs Coding for Apo-Polysialoglycoprotein of Rainbow trout Eggs.

The Journal of Biological Chemistry   Vol. 263 ( 33 ) page： 17678-17684   1988

A Proteinase Associated with Cortices of Rainbow Trout Eggs and Involved in Fertilization-Induced Depolymerlzation of Polysialoglycoproteins

Developmental Biology   Vol. 129   page： 270-274   1988

Use of a Bacteriophage-derived Endo-N-acetylneuraminidase and an Equine Antipolysialyl Antibody to characterize the Polysialyl Residues in Salmonid Fish Egg Polysialoglycoproteins.

The Journal of Biological Chemistry   Vol. 263 ( 34 ) page： 18269-18276   1988

comparative Structures of the Apopolysialoglycoproteins from Unfertilized and Fertilized Eggs of Salmonid Fishes

Biochemistry   Vol. 27   page： 7141-7145   1988

KDN-glycoprotein: A novel deaminated neuraminic acid-rich glycoprotein isolated from vitelline envelope of rainbow trout eggs.(共著)

Biochemical and Biophysical Research Communication   Vol. 153   page： 172-176   1988

Localization of polysialoglycoprotein as a major glycoprotein component in cortical alveoli of the unfertilized eggs of Salmo gairclneri.(共著)

Developmental Biology   Vol. 123   page： 442-454   1987

A naturally occurring deaminated neuraminic aced, 3-deoxy-D-glycero-D-galacto-nonulosonic acid (KDN). Its unique occurrence of the nonredueing encls of oligosialyl chains in polysialoglycoprotein of rainbow trout eggs.(共著)

The Journal of Biological chemistry   Vol. 261   page： 11550-11557   1986

Polysialoglycoproteins of Salmonidae Fish Eggs. Complete structure of 200-kDa polysialoglycoprotein from the unfertilizaed eggs of rainbow trout.

The Journal of Biological Chemistry   Vol. 261 ( 12 ) page： 5262-5269   1986

A mechanistic consideration of the hydrazinolysis of 3-O-substituted, 2-acetgmido-2-deoxy-D-hexopyranosyl and-D-hexitol residues in the absence and presence of hydroziniun sulfate.(共著)

Carbhyolrate Research   Vol. 135   page： 342-347   1985

Fish Egg Polysialoglycoproteins : Circular Dichroism and Proton Nuclear Magnetic Resonance Studies of Novel Oligosaccharide Units Containing One Sialidase-Resistant N-Glycolylneuraminic Acid Residuein Each Molecule

Biochemistry   Vol. 23   page： 305-309   1984

Novel oligosaccharide chains on polysialog lycoproteins isolated from rainbow trout eggs.(共著)

Biochemistry   Vol. 23   page： 305-310   1984

Isolation and structures of the third m^ceJor type of carbohydrate units in polysialoglycoproteins from rainbow trout eggs.(共著)

Biochemistry International   Vol. 8   page： 573-579   1984

第2章糖鎖と生命　第1節 受精

北島健（ Role： Sole author）

エヌ・ティー・エス  2015 

Polysialic acid

Chihiro Sato, Ken Kitajima （ Role： Joint author）

Springer  2015 

Polysialyltransferase assay

Masaya Hane, Ken Kitajima, Chihiro Sato（ Role： Joint author）

Springer  2015 

Flagellasialin: A highly glycosylated GPI-anchored protein involved in intracellular Ca2+ regulation in sea urchin sperm.

Kanazawa T**, Suzuki E*, Miyata S, Sato C, and Kitajima K.（ Role： Joint author）

Springer  2015 

Enzyme assay of polysialyltransferase

Kitajima K, Sato C. （ Role： Joint author）

JCGGDB  2014 

Advanced technologies in sialic acid and sialoglycoconjugate analysis

Ken Kitajima, Nissi Varki, and Chihiro Sato.（ Role： Joint author）

Springer  2013 

N-acetylneuraminic acid 9-phosphatase (NANP)

Ken Kitajima（ Role： Sole author）

Springer  2013 

Biological problems, methods, and applications (The roles of carbohydrate binding in cell adhesion and inflammation.)

Kitajima, K. and Sato, C.（ Role： Joint author）

John Wiley and Sons  2011 

Analysis of glycan-protein interaction by frontal affinity chromatofraphy and Biacore in Methods in Enzymology (Minoru Fukuda ed. in glycomics)

Sato C., Kitajima, K. and Sato, C.（ Role： Joint author）

Elsevir science  2010 

生物学辞典

北島健（ Role： Joint author）

東京化学同人  2010 

18. Enzyme assay of polysialyltransferase. in Glycoscience Protocol Online

Ken KItajima（ Role： Joint author）

JCGG-DG  2010 

Glycoscience Lab Manual (Membrane microdomain as a platform of carbohydrate-mediated interaction during early development of medaka fish.)

Adachi, T., Sato, C., and Kitajima, K.（ Role： Joint author）

Springer  2008 

Glycoscience Lab Manual (Structural analysis of polysialic acid)

Sato, C., and Kitajima, K.（ Role： Joint author）

Springer  2008 

実験医学・受精における糖鎖の役割

北島健（ Role： Sole author）

羊土社  2007 

細胞工学・シアル酸の構造多様性とその生物学的意義

北島健、郷慎司、藤田明子、佐藤ちひろ（ Role： Joint author）

秀潤社  2007 

新編精子学・精子表面の糖脂質の役割

北島健（ Role： Sole author）

東京大学出版会  2006 

未来を拓く糖鎖科学・メダカ初期胚における糖鎖に富む生体膜マイクロドメインの役割

北島健（ Role： Sole author）

金芳堂  2005 

未来を拓く糖鎖科学・ポリシアル酸の構造解析

北島健（ Role： Joint author）

金芳堂  2005 

遺伝子医学MOOK 3　糖鎖と病気・4)ポリシアル酸. 5糖鎖と発生

佐藤ちひろ、北島健（ Role： Joint author）

メディカルドゥ  2005 

生化学実験講座

北島健（ 編：日本生化学会編）（ Role： Joint author）

東京化学同人  2000 

KDN：デアミノノイラミン酸

日本生化学会編　基礎生化学実験法、東京化学同人  2000 

Occurrence of alpha-2,8-linked oligosialic acid residues in mammalian glycoproteins.

Sialobiology and Other novel Form of Glycosylation, a monograph (Inoue, Y., Lee, Y. C., and Troy, F. A., eds) Gakushin Syuppan, Osaka, Japan  1999 

細胞機能と代謝マップ

"安形高志,北島健,井上康男（ 編：日本生化学会）"（ Role： Joint author）

東京化学同人  1997 

生体物質の化学(共著)

大日本図書  1996 

新化学ライブラリー

北島健、井上康男（ 編：日本化学会）（ Role： Joint author）

大日本図書  1996 

KDN-ganglioside

Guide to techniques in Ganglioside Research  1995 

生物化学実験法シリーズ:ガングリオシド研究法

"北島健,井上貞子（ 編：鈴木康夫,安藤進）"（ Role： Joint author）

学会出版センター  1995 

ポリシアル酸 (共著)

講談社グリコバイオロジーシリーズ  1993 

Glycan-mediated Interactions on Pig Sperm Lipid Rafts during Fertilization. Invited International conference

Ken Kitajima

Proceedings of the APMC11 / MST33 / AAT39 Conference 

曖昧な生体分子：糖鎖の生体機能を探る

北島　健

第7回「ナノカーボンバイオセンサーの医療応用研究会」 

精子膜マイクロドメイン局在糖鎖の受精における役割

北島健

第13回日本糖鎖科学コンソーシアムシンポジウム 

Functional significance of glycan-mediated interactions on sperm microdomains during fertilization International conference

Ken Kitajima

23rd International Symposium on Glycoconjugates (Glyco23) 

Effects of psychiatric disorders-related intronic single nucleotide polymorphisms (iSNPs) of the polysialyltransferase ST8SIA2/STX gene. International conference

Masaya Hane, Ken Kitajima, Chihiro Sato

23rd International Symposium on Glycoconjugates (Glyco23) 

Analysis of a ligand-binding mechanism among sialic-acid binding sites in Siglec-7. International conference

Di Wu, Akiko Fujita, Yuko Yasukawa, Yoshihito Taniguchi, Yasuhiro Kamei, Chihiro Sato, Ken Kitajima.

23rd International Symposium on Glycoconjugates (Glyco23) 

Catabolism of sialic acid residues during pre-hatching development. International conference

Bo Fu, Di Wu, Chihiro Sato, Ken Kitajima

23rd International Symposium on Glycoconjugates (Glyco23) 

Comparative characterization of the insect CMP-sialic acid synthetases in the enzyme activity and intracellular localization.

Di Wu, Akiko Fujita, Anne Harduin-Lepers, Philippe Delannoy, Vladislav M. Panin, Chihiro Sato, and Ken Kitajima.

4th Austria/Japan seminar on comparative and developmental glycobiology 

Mining of marine invertebrate glycoconjugates with anti-microbial activity. Invited International conference

Ken Kitajima, Yann Guérardel

Bio-Asia 2015 Annual Conference 

A polysialyltransferase SNP in a schizophrenic patient brings about the production of polysialic acids showing impaired binding and signaling of BDNF and FGF2. International conference

8th International Symposium on Glycosyltransferases 

New features on biosynthesis and degradation of free sialic acids. International conference

Kiel University Department of Chamistry Seminar 

Sia usage: How does the cell express particular sialic acid species? International conference

Sialoglyco 2010, August, 21-26, 2010; Potsdam, Germany 

Discovery of a 16-30-kDa, highly glycosylated glycoprotein from pig seminal plasma (WGA16) that regulates sperm fertilizability. International conference

25th International Carbohydrate Symposium (ICS2010) Makuhari Messe International Convention Complex; Tokyo(Chiba), Japan 

ラット海馬におけるシアル酸分子種含有糖鎖の発現.

日本薬学会第130年会 

細胞外シアル酸およびその前駆体のシアル酸生合成への効果

日本農芸化学会2010年度大会. 

グリコサミノグリカン鎖と脳由来神経栄養因子の相互作用の解析.

日本農芸化学会2010年度大会. 

ブタ精子細胞膜マイクロドメイン局在糖タンパク質の受精における機能

日本農芸化学会2010年度大会. 

CMP-シアル酸合成酵素のCMP-KDN合成能の構造的基盤.

日本農芸化学会2010年度大会. 

シグレック-7のオリゴシアル酸結合能および新規シアル酸結合ドメインの存在証明.

CREST糖鎖最終シンポジウム. 

ポリシアル酸と統合失調症.

第7回糖鎖科学コンソーシアムシンポジウム-糖鎖研究と他領域との統合[グライコケミカルバイオロジーとグライコテクノロジーへの展開] 

Molecular mechanism for differential recognition of the C-5 substituents of sialic acid by CMP-sialic acid synthetases: Identification of the evolutionally conserved sialic acid recognition region. International conference

20th International Symposium on Glycoconjugate (GlycoXX 2009); Nov 29-Dec 4, 2009; San Juan, Puerto Rico 

A new function of polysialic acid on NCAM as the reservoir for the particular groups of neurotrophins, growth factors, and neurotransmitters that regulate the neural activity. International conference

20th International Symposium on Glycoconjugate (GlycoXX 2009); Nov 29-Dec 4, 2009; San Juan, Puerto Rico 

In silico and in vitro binding studies predict a novel sialic acid binding site on the sialic acid binding Ig-like lectin-7 (Siglec-7). International conference

20th International Symposium on Glycoconjugate (GlycoXX 2009); Nov 29-Dec 4, 2009; San Juan, Puerto Rico 

Membrane Microdomains as a Platform of Carbohydrate-mediated Cell-cell Interactions during Gastrulation. International conference

4th 2009 Annual Meeting of Koren Society of Glycoscience, 2009 KSG International Glycoscience Symposium; Dajeon, Korea 

シアル酸結合免疫グロブリン様レクチン(シグレック)-7によるシアロ糖鎖認識の生化学的および分子ドッキング解析.

第47回日本生物物理学会年会. 

魚類CMP-シアル酸合成酵素の構造とシアル酸分子種認識.

第82回日本生化学会大会. 

CMP-シアル酸合成酵素のシアル酸分子種認識および核局在決定領域の生物種間比較.

第82回日本生化学会大会. 

ポリシアル酸転移酵素の一塩基多型変異体の酵素活性と統合失調症との関連.

第82回日本生化学会大会. 

分子ドッキングおよび生化学的結合解析によるシグレック-7の糖鎖認識の構造学的知見.

第82回日本生化学会大会. 

マウス新生仔脳局在A2B5エピトープ含有糖タンパク質のシアロ糖鎖の特徴と生合成

第82回日本生化学会大会. 

NCAMを修飾するポリシアル酸鎖とFGF-2の相互作用解析.

第82回日本生化学会大会. 

Siglec-7のオリゴシアル酸結合能の解析と新規シアル酸結合ドメインの存在検証.

第82回日本生化学会大会. 

マウス脳発達段階におけるA2B5エピトープ含有糖タンパク質の発現と解析.

糖鎖科学名古屋拠点[若手の力]フォーラム第7回. 

ブタ精子膜マイクロドメインに局在する糖タンパク質の役割解明.

糖鎖科学名古屋拠点[若手の力]フォーラム第7回. 

メダカ初期胚生体膜マイクロドメインに局在する巨大糖タンパク質の発現解析と精製・性質.

糖鎖科学名古屋拠点[若手の力]フォーラム第7回. 

ウニの受精・発生過程における2E8糖鎖エピトープの発現と機能解析.

糖鎖科学名古屋拠点[若手の力]フォーラム第7回. 

メダカ初期胚生体膜マイクロドメイン局在メガ糖タンパク質の発現解析と精製.

日本動物学会第80回大会. 

ウニの受精および初期発生における2E8糖鎖抗原の発現変化.

日本動物学会第80回大会. 

ブタ精子細胞膜マイクロドメイン局在糖タンパク質の同定と受精能獲得における変化.

日本動物学会第80回大会. 

分子ドッキングおよび生化学的結合解析によるシグレック-7の糖鎖認識の構造学的知見.

第29回日本糖質学会年会 

魚類CMP-シアル酸合成酵素の構造とシアル酸分子種認識.

第29回日本糖質学会年会 

ウニの受精・発生過程における2E8糖鎖エピトープの発現と機能解析

第29回日本糖質学会年会 

NCAMを修飾するポリシアル酸鎖とFGF-2の相互作用解析.

第29回日本糖質学会年会 

メダカ初期胚生体膜マイクロドメインに局在する巨大糖タンパク質の発現解析と精製

第29回日本糖質学会年会 

Siglec-7のオリゴシアル酸結合能の解析と新規シアル酸結合ドメインの存在検証.

第29回日本糖質学会年会 

マウス脳発達段階特異的に発現するA2B5エピトープ含有糖タンパク質の糖鎖解析.

第29回日本糖質学会年会 

統合失調症に関わるポリシアル酸転移酵素変異体の活性解析.

第29回日本糖質学会年会 

CMP-シアル酸合成酵素の基質認識および細胞内局在決定領域の生物種間比較.

第29回日本糖質学会年会 

Glycosaminoglycan-dependent complex formation of 70-kDa heat shock protein.

第29回日本糖質学会年会 

ブタ精子マイクロドメインに局在し多分散性を示す糖タンパク質の同定.

第29回日本糖質学会年会 

CMP-シアル酸合成酵素の進化とシアル酸認識機構の相関.

FCCAグライコサイエンス若手フォーラム. 

ポリシアル酸と線維芽細胞増殖因子との相互作用解析.

FCCAグライコサイエンス若手フォーラム. 

分子モデリング法による熱ショックタンパク質(Hsp70)の酸性糖脂質結合性の解析.

名古屋大学若手女性研究者サイエンスフォーラム. 

オリゴシアル酸とSiglec-7との相互作用解析.

第73回日本生化学会中部支部例会. 

Novel aspects of substrate specificity and nuclear localization of CMP-sialic acid synthetases as revealed by studies of fish enzymes.

ORI Seminar; April 27, 2009; Ocean Research Institute, University of Tokyo, Tokyo 

Polysialic acid is not a negative regulator any longer in neurogenesis and neuronal functions: A new finding of its binding to a particular group of neurotransmitters. International conference

Gordon Research Conference on Glycobiology 

Membrane microdomains as a plarform of carbohydrate- and protein-mediated cell-cell interaction in fertilization and early development International conference

Biochemistry and Molecular Biology 

A one-day symposium on Sialyltransferases, Functional Glycomics, and Genomics of Zebrafish International conference

Functional Glycomics, and Genomics of Zebrafish 

Membrane microdomains from early gastrula embryos of medaka are a platform of E-cadherin- and LeX-mediated cell-cell interactions during epiboly International conference

14th Japanese Medaka and Zebrafish Meeting 

Occurrence of the Cyclic Sialic Acid in Mammalian Cells and Tissues As Demonstrated by Chemical Methods.

24th International Carbohydrate Symposium 

Significance of the existence of deaminoneuraminic acid (KDN) in mammalian cells in Its metabolic and functional features. International conference

SialoGlyco Conference 2008 

シアロメタボロームから見た生命科学シンポジウム「次世代の糖鎖科学」

北島　健

日本農芸化学会2008年度大会 

ウニ精子表面シアロ糖鎖の受精における役割

北島健

日本動物学会第78回大会　シンポジウム「受精シンポジウム：温故知新による受精研究ネクストステージの幕開け-２部-」(2007年9月20-23日; 弘前大学, 弘前) 

Discovery of Polysialic Acid in Microglia. Expression Changes of α2,8-Sialyltransferases During Activation of a Mouse Microglia Cell Line International conference

19th International Symposium on Glycoconjugates (July 15-20, 2007; Cairns, Australia) 

Polysialic acids on O-glycans: Their occurrence, structural diversity, and biosynthesis International conference

Polysialic acid: Chemistry, Biology, Translational Aspects, 3rd International Meeting (Bad Lauterberg, Germany) 

A short-term regulation of polysialic acid expression in microglia International conference

Gordon Research Conference on Glycobiology (Ventura, U.S.A.) 

ポリシアル酸：普遍的存在、構造多様性および機能

北島健

第４回糖鎖科学コンソーシアムシンポジウム～糖鎖機能の解明からシステム糖鎖生物学への統合へ向けて～　(2006年10月23-24日；東京) 

Discovery of Polysialic Acid in Microglia. Expression Changes of α2,8-Sialyltransferases During Activation of a Mouse Microglia Cell Line International conference

5th International Symposium on Glycosyltransferases (June 25-28, 2006; Tsukuba, Japan) 

Development of a chemical method for detecting a unique sialic acid, cyclic neuraminic acid, in naturally-occurring sialyl glycoconjugates International conference

Pacifichem 2005 (2005.12; Hawaii, USA) 

Significance of membrane microdomains in the carbohydrate-dependent cell-cell interactions during early development of medaka fish International conference

2nd Japan-The Netherlands Glycobiology Symposium (April 18-20, 2005; Utrecht, The Netherlands) 

An essential role of carbohydrate-enriched membrane microdomains (rafts) in gastrulation of medaka fish, Oryzias latipes International conference

Gordon Research Conference on Glycobiology (Ventura, U.S.A.) 

ポリシアル酸の鎖長多様性と神経系における新機能

北島健

第23回シアル酸研究会講演会「シアル酸と記憶」(2005年12月; 東京) 

A carbohydrate-mediated binding of sperm gangliosides with the sperm binding protein in vitelline layer as a molecular base for the sea urchin sperm-egg interaction International conference

4th International Symposium on the Molecular and Cell Biology of Egg- and Embryo-Coats (MCBEEC2004) (2004.11; Ise, Japan) 

Polysialic acid in mammary gland International conference

4th International Symposium on Glycosyltransferases GlycoT2004. (2004.11; Le Touquet, France) 

生体膜マイクロドメインを通して糖鎖認識分子群を探究する

北島健

第53回高分子討論会「ここまできた糖鎖工学と化学生物学の展開」(2004.9.; 札幌） 

Linkage and chain length diversities of the polysialic acid in animal glycoproteins International conference

Sialobiology 2004. 4th International Conference. (2004.7; St Andrews, UK) 

糖脂質マイクロドメイン：細胞間相互作用を媒介する分子集合体

北島健

日本農芸化学会中部支部第１４０回例会.　シンポジウム「ポスト・ポストゲノム：糖と脂質の最前線」(岐阜) 

Identification and characterization of a new heat shock protein-like lectin on the egg surface of sea urchin International conference

21st International Lectin Meeting (2004.5; Shonan, Japan) 

Identification of glycosylated alpha-lactoalbumin as endogenous substrate for beta-1,4-galactosyltransferase (GalT) in colostrum International conference

XVIth International Symposium on Glycoconjugates 

Molecular cloning and developmental expression of two alpha-2,8-polysialyltransferases in rainbow trout ovary." International conference

XVIth International Symposium on Glycoconjugates 

Sialic acid-dependent sperm raft-egg raft interactions at fertilization. International conference

XVIth International Symposium on Glycoconjugates (August 19-24, 2001The Hague, The Netherlands) 

Biosynthesis of a major, carbohydrate-rich cortical galveolus glycoprotein (hyosophorin) during oogenesis of Oryzias latipes International conference

14th International Congress of Developmental Biology 

Identification of adipo Q, an adipocyte specific glycoprotein, as a new oligosialic acid-containing glycoprotein and a possible substrate for the alpha2,8-sialyltransferase III (ST8Sia III) International conference

International Symposium on Protein Trafficking, Glycosylation, and human health 

Di/oligosialic acid in glycoproteins: Differentiation-dependent expression in an adipocyte tissue specific glycoprotein, adipo Q. International conference

Gordon Research Conference on Glycobiology 

The chicken Zp-C gene. Gene structure, granulosa-specific expression and promoter activity International conference

3rd International Symposium of the Molecular and Cellular Biology of the Egg and Embryo Extracellular Matrix 

Expression and glycosylation of a major, carbohydrtate-rich, cortical alveolus glycoprotein (hyosophorin) during oogenesis of medaka fish, Oryzias latipes. International conference

3rd International Symposium of the Molecular and Cellular Biology of the Egg and Embryo Extracellular Matrix 

Expression and glycosylation of a major, carbohydrtate-rich, cortical alveolus glycoprotein (hyosophorin) during oogenesis of medaka fish, Oryzias latipes International conference

3rd International Symposium of the Molecular and Cellular Biology of the Egg and Embryo Extracellular Matrix (August 27-September 1, Lake Tahoe, California, U.S.A.) 

KDNの生合成に関与する酵素の同定および性質

北島　健

第21回日本糖質学会年会（2000年7月27-29日, 名古屋国際会議場, 名古屋） 

Di- and oligosialic acids as novel carbohydrate epitopes in leukocytes. International conference

7th Conference on human leukocyte differentiation antigens 

Di- and oligosialic acids as novel carbohydrate epitopes in leukocytes International conference

7th Conference on human leukocyte differentiation antigens (Harrogate, UK, June 20-24, 2000) 

Cloning and characterization of N-acetylgalactosaminide (2,6-sialyltransferase (ST6GalNAc II) responsible for sialylation of rainbow trout egg polysialoglycoprotein. International conference

2nd International Symposium on Glycosyltransferase: Glycosyltransferases in the New Millenium 

Spontaneous galactosylation of agalactoglycoproteins in colostrum. A possible role of milk 1,4-galactosylatransferase. International conference

2nd International Symposium on Glycosyltransferase: Glycosyltransferases in the New Millenium 

Gametic cell rafts-mediated sperm-egg interaction at fertilization International conference

Invited Seminar at Loeb Health Research Institute (University of Ottawa, ON, Canada, May 8, 2000) 

Biosynthesis of deaminoneuraminic acid (KDN) in mammalian cells International conference

2nd International Symposium on Glycosyltransferase: Glycosyltransferases in the New Millenium (May 12-14, 2000, The Hospital for Sick Children, Toronto, Canada) 

動物細胞表面のシアロ糖鎖工学：N-アセチルノイラミン酸からデアミノノイラミン酸（KDN）へのin vitro改変

仲田大輔、松田　幹、北島　健

日本農芸化学会2000年度大会 ( 東京, 2000年3月31日-4月2日) 

シアル酸は面白い～シアロバイオサイエンスへの招待

(財)科学技術交流財団「糖鎖材料生命工学研究会」セミナー (名古屋大学VBL; 11月24日 1999) 

ニジマス卵巣a2,6-シアル酸転移酵素(ST6GalNAcII)およびa2,8-ポリシアル酸転移酵素(ST8Sia)のcDNAクローニングと卵形成過程における発現

朝比奈慎二、松野みどり、中瀬昌之、佐藤ちひろ、青木直人、松田幹、北島健

第72回日本生化学会大会 

精子細胞膜の糖脂質ミクロドメインの受精における役割

第72回日本生化学会大会 シンポジウム講演 (横浜, 10月6-9日 1999) 

A role of b-1,4-galactosyltransferase in in situ galactosylation of degalactosylated glycoproteins in colostrum. International conference

XVth International Symposium on Glycoconjugates 

Glycosphingolipid-enriched microdomain on gametic cells as functional domain for sperm-egg interaction coupled with signal transduction International conference

Special Seminar at Department of Med: Biological Chemistry, University of California, Davis, U.S.A. 

Egg receptor for sperm binds to gangliosides in the low density detergent-insoluble membrane (LD-DIM) domain of the sperm surface. Possible involvement of the LD-DIM in sperm-egg binding coupled with signal transduction during fertilization International conference

XVth International Symposium on Glycoconjugates (August 22-26, Hotel East 21, Tokyo, Japan 1999) 

Glycosphingolipid-enriched microdomain on gametic cells as functional domain for sperm-egg interaction coupled with signal transduction International conference

Gordon Research Conference on Fertilization and Activation of the Development (July 25-30, Holderness School, Plymouth, New Hampshire, U.S.A. 1999) 

新規なシアル酸含有糖タンパク質の生理活性

連続公開セミナー「糖鎖の新しい生理活性」第5回セミナー (京都大学農学部, 12月12日 1998) 

Occurrence of oligosialic acid residues in vertebrate glycoproteins International conference

International Symposium on Sialobiology and Other Novel Forms of Glycosylation (Taipei, Taiwan, November 9-13, 1998) 

オリゴシアル酸含有糖タンパク質の新しい化学的および免疫化学的解析法の開発と哺乳動物細胞における普遍的存在の証明

佐藤ちひろ、本田直輝、太田薫、福岡秀幸、井上貞子、松田幹、北島健

第71回日本生化学会大会 (名古屋、10.14-10.17 1998) 

動物細胞におけるデアミノノイラミン酸（KDN）の生合成経路およびKDN複合糖質の発現の調節機構の解析

北島健、安形高志、仲田大輔、松田幹、Frederic A. Troy, II

第71回日本生化学会大会　シンポジウム「糖鎖生物学の新たな展開と可能性：糖鎖合成・発現の調節機構」 

Expression of alpha2,8-linked oligosialic acid-containing glycoproteins in mammalian cells, depending on development, cell differentiation, and overexpression of polysialyltransferase genes International conference

XIXth International Carbohydrate Symposium 

糖タンパク質における新しいシアル酸含有糖鎖構造とその機能

北島　健

平成10年度日本農芸化学会 シンポジウム「糖鎖の精密構造とその機能：生命現象に関わる糖鎖」（名古屋、名城大学、3月31日～4月3日 1998) 

Synthesis of neoglycoconjugates containing deaminated neuraminic acid (KDN) using rat liver α2,6-sialyltransferase. International conference

10th Annual Meeting of Japanese Association for Animal Cell Technology 

Structure and physiological activities of hyosophorin, a cortical alveolus glycoprotein of fish eggs International conference

2nd International Symposium on the Molecular and Cell Biology of Egg- and Embryo-coats 

Frequent occurrence of oligosialyl units in vertebrate glycoprotiens as evidenced by new chemical and immunochemical methods International conference

XIVth International Symposium on Glycoconjugates 

Oligosialic acid-containing glycoproteins occur in vertebrates more frequently than recognized until now: their distribution, function, and biosynthesis International conference

Gordon Research Conference on Glycobiology 

新しい機能性糖鎖を探索する

北島　健

第32回糖鎖生命科学セミナー　（東京工業大学、1月10日 1997) 

新しい複合糖質の発見と研究展開

北島　健

講演会「糖鎖工学：多様な生命現象へのアプローチ」 

Purification, characterization and catalytic mechanism of a novel sialidase, deaminoneuraminidase (KDNase), from Sphingobacterium multivorum International conference

1st. Austrasia Conference on the Chemistry and Biochemistry of Sialic Acid-Recognising Proteins 

Deaminoneuraminic acid (KDN)-containing glycoconjugates: Biological functions and potential usefulness in glycotechnology International conference

First International Symposium on Glycobiology: 3rd Generation of biotechnology as a new frontier in biological science 

魚卵に学ぶ. N-グリコシド型糖タンパク質の構造と機能

北島　健

平成7年度日本水産学会年会 ミニシンポジウム「海洋生命科学における糖鎖生物学・工学」 

A possible polysialylation signal in the core glycan chain of N-CAM International conference

13th International Symposium on Glycoconjugates 

Unique structures and structural chains of the cortical alveolar-derived glycopolyproteins in fish eggs upon fertilization and during early development International conference

3rd International Marine Biotechnology Conference (Tromso, Norway, August 7-12, 1994) 

Discovery, purification, and properties of KDNase devoid of sialidase activity: Is KDN a sialic acid? International conference

17th International Carbohydrate Symposium (Ottawa, Canada, July 17-22, 1994) 

初期胚表面に存在する巨大糖鎖の機能とその分子機構の解明

2010 - 2013.3

科学研究費補助金  基盤研究(B)，課題番号：22380187

北島　健

T細胞と抗原提示細胞の相互作用における接着分子CADM1とCRTAMの役割

2009.11 - 2010.3

Grant-in-Aid for Scientific Research 

細胞外熱ショックタンパク質70-酸性脂質複合体の構造と生理学的役割の解明

2009.4 - 2010.3

Grant-in-Aid for Scientific Research 

動物精子表面糖鎖による新しい受精能制御の分子機構の解明

2007.4 - 2010.3

科学研究費補助金  基盤研究（Ｂ）（一般），課題番号：19380192

北島　健

Roles of acidic glycoconjugates in mammalian fertilization

2005.4 - 2007.3

Grant-in-Aid for Scientific Research 

細胞接着に関わるシアル酸の構造変化と細胞接着制御の解明

2002.11 - 2008.3

科学研究費補助金  科学技術振興機構

神奈木玲児

細胞表面に見出される新しい酸性糖鎖の機能に関する共同研究

1998.1 - 1999.12

科学研究費補助金  国際学術研究

糖タンパク質糖鎖におけるオリゴシアル酸鎖の発見とその普遍的存在分布の証明

1998.1 - 1999.12

科学研究費補助金  基盤研究(C)(2)

細胞間接着における糖質ー糖質間相互作用の役割と分子機構の解明

1998.1 - 1998.12

科学研究費補助金  特定領域研究(A)(2)

細胞表面に見出される新しい酸性糖鎖の機能に関する共同研究

1997.1 - 1998.12

科学研究費補助金  国際学術研究

細胞間接着における糖質ー糖質間相互作用の役割と分子機構の解明

1997.1 - 1997.12

科学研究費補助金  重点領域研究

デアミノノイラミン酸残基特異的な新規シアリターゼ(KDNase)

1996.1 - 1996.12

科学研究費補助金  萌芽的研究

細胞表面に見出された新規ポリシアル酸、KDN、硫酸化糖鎖の機能に関する共同研究

1996.1 - 1996.12

科学研究費補助金  国際学術研究

デアミノノイラミン酸(KDN)残基をもつ新しい生理活性複合糖質の開発と応用

1995.1 - 1996.12

科学研究費補助金  試験研究(B)

デアミノノイラミン酸残基特異的な新規シアリダーゼ(KDNase)

1995.1 - 1995.12

科学研究費補助金  一般研究(C)

哺乳動物正常及び腫瘍細胞におけるKDN-複合糖質の分布及び機能に関する共同研究

1995.1 - 1995.12

科学研究費補助金  国際学術研究