Updated on 2023/10/20

写真a

 
KITAJIMA, Ken
 
Organization
Institute for Glyco-core Research Professor
Bioscience and Biotechnology Center Professor
Graduate School
Graduate School of Bioagricultural Sciences
Title
Professor
Contact information
メールアドレス

Degree 1

  1. Doctor of Science ( 1987.3   The University of Tokyo ) 

Research Interests 6

  1. Biotechnology

  2. Reproductive Biochemistry

  3. Developmental Biology

  4. Molecular Biology

  5. Biological Chemistry

  6. Glycobiology

Research Areas 4

  1. Others / Others  / Glycobiology

  2. Others / Others  / Structured Biochemistry

  3. Others / Others  / Applied Molecular Cell Biology

  4. Others / Others  / Developmental Biology

Current Research Project and SDGs 6

  1. Development of methods for diagnosis and treatment of mental disorders

  2. シアロ糖鎖代謝異常によるヒト疾患の病理学的研究

  3. Role of Surface Glycoconjugates in cell-cell Interaction.

  4. 生命情報のハードウェアを解析・構築する糖鎖生命情報科学の創出

  5. Role of membrane microdomain in fertilization and early develpment

  6. 糖鎖機能の糖鎖工学的利用

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Research History 12

  1. Nagoya University   Institute for Glyco-core Research   Professor

    2021.1

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    Country:Japan

  2. 名古屋大学 生物機能開発利用研究センター・教授

    2004.4

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    Country:Japan

  3. 名古屋大学大学院生命農学研究科・教授(兼任)

    2004.4

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    Country:Japan

  4. 名古屋大学 生物機能開発利用研究センター・助教授

    2003.4 - 2004.3

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    Country:Japan

  5. 名古屋大学生命農学研究科・助教授(兼任)

    2002.4 - 2004.3

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    Country:Japan

  6. 名古屋大学高等研究院・流動教員(兼任)

    2002.2 - 2005.3

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    Country:Japan

  7. 名古屋大学 生物分子応答研究センター・助教授

    2000.4 - 2003.3

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    Country:Japan

  8. 名古屋大学大学院生命農学研究科 助教授

    1998.4 - 2000.3

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    Country:Japan

  9. 名古屋大学農学部 助教授

    1996.6 - 1998.3

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    Country:Japan

  10. 東京大学大学院理学系研究科 助手

    1994.4 - 1996.5

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    Country:Japan

  11. 東京大学理学部 助手

    1989.4 - 1994.3

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    Country:Japan

  12. 日本学術振興会 特別研究員PD

    1987.4 - 1989.3

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    Country:Japan

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Education 3

  1. The University of Tokyo   Graduate School, Division of Science   Department of Biophysics and Biochemistry

    1984.4 - 1987.3

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    Country: Japan

  2. The University of Tokyo   Graduate School, Division of Science   Department of Biophyscs and Biochemistry

    1982.4 - 1984.3

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    Country: Japan

  3. The University of Tokyo   Faculty of Science   Department of Biophyscs and Biochemistry

    1978.4 - 1982.3

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    Country: Japan

Professional Memberships 10

  1. Japanese Society of Carbohydrate Research

    2023.7

  2. Japanese Society of Carbohydrate Research

    2007.4

  3. Japanese Society of Carbohydrate Research

    1999.4

  4. 日本農芸化学会   中部支部会評議員

    2008.4

  5. 日本生化学会

  6. 日本動物学会

  7. Forum: Carbohydrate Coming of Age

    2001.4 - 2008.3

  8. Society for Glycobiology

  9. 日本分子生物学会

  10. 日本発生生物学会

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Awards 1

  1. Promotion Award of Japanese Society of Carbohydrate Sciences

    1999.8  

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    Country:Japan

 

Papers 281

  1. Interactions between polysialic acid and dopamine-lead compounds as revealed by biochemical and <i>in silico</i> docking simulation analyses

    Hayakawa Kaito, Hane Masaya, Hamagami Hiroki, Imai Miki, Tanaka Hiroshi, Kitajima Ken, Sato Chihiro

    GLYCOCONJUGATE JOURNAL   Vol. 40 ( 4 ) page: 461 - 471   2023.8

  2. Forced expression of a2,3-sialyltransferase IV rescues impaired heart development in a2,6-sialyltransferase I-deficient medaka Reviewed International coauthorship International journal

    Omoto Takayuki, Wu Di, Maruyama Emi, Tajima Katsue, Hane Masaya, Sato Chihiro, Kitajima Ken

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 649   page: 62 - 70   2023.3

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2023.01.010

    Web of Science

  3. Critical Role of the Cortical Alveolus Protease Alveolin in Chorion Hardening In Vivo at Medaka Fertilization Reviewed International journal

    Fu Bo, Wu Di, Yasumasu Shigeki, Hane Masaya, Sato Chihiro, Kitajima Ken

    BIOMOLECULES   Vol. 13 ( 1 )   2023.1

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/biom13010146

    Web of Science

  4. Implication of N-glycolylneuraminic acid in regulation of cell adhesiveness of C2C12 myoblast cells during differentiation into myotube cells Reviewed International journal

    Go Shiori, Sato Chihiro, Hane Masaya, Go Shinji, Kitajima Ken

    GLYCOCONJUGATE JOURNAL   Vol. 39 ( 5 ) page: 619 - 631   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10719-022-10049-9

    Web of Science

  5. Identification and characterization of a deaminoneuraminic acid (Kdn)-specific aldolase from Sphingobacterium species Reviewed International journal

    Nakagawa Takahiro, Iwaki Yuya, Wu Di, Hane Masaya, Sato Chihiro, Kitajima Ken

    GLYCOBIOLOGY     2022.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/glycob/cwac053

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  6. A novel C-domain-dependent inhibition of the rainbow trout CMP- sialic acid synthetase activity by CMP-deaminoneuraminic acid Reviewed International coauthorship International journal

    Wu Di, Gilormini Pierre-Andre, Toda Sakura, Biot Christophe, Lion Cedric, Guerardel Yann, Sato Chihiro, Kitajima Ken

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 617   page: 16 - 21   2022.8

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2022.05.031

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  7. Sulfation of sialic acid is ubiquitous and essential for vertebrate development Reviewed International coauthorship International journal

    Ertunc Nursah, Phitak Thanyaluck, Wu Di, Fujita Hiroshi, Hane Masaya, Sato Chihiro, Kitajima Ken

    SCIENTIFIC REPORTS   Vol. 12 ( 1 )   2022.7

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-15143-4

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  8. The alpha 2,8-sialyltransferase 6 (St8sia6) localizes in the ER and enhances the anchorage-independent cell growth in cancer Reviewed International journal

    Hatanaka Rina, Araki Erino, Hane Masaya, Go Shiori, Wu Di, Kitajima Ken, Sato Chihiro

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 608   page: 52 - 58   2022.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2022.03.146

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  9. Shrimp thrombospondin (TSP): presence of O-beta 1,4 N-acetylglucosamine polymers and its function in TSP chain association in egg extracellular matrix Reviewed International coauthorship International journal

    Magerd Sirilug, Senarai Thanyaporn, Thongsum Orawan, Chawiwithaya Chidchanok, Sato Chihiro, Kitajima Ken, Weerachatyanukul Wattana, Asuvapongpatana Somluk, Surinlert Piyaporn

    SCIENTIFIC REPORTS   Vol. 12 ( 1 )   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-022-11873-7

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  10. Comprehensive Analysis of Oligo/Polysialylglycoconjugates in Cancer Cell Lines Reviewed International journal

    Hane Masaya, Kitajima Ken, Sato Chihiro

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 23 ( 10 )   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms23105569

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  11. Polysialylation in a DISC1 Mutant Mouse Reviewed International journal

    Takahashi Yuka, Abe Chikara, Hane Masaya, Wu Di, Kitajima Ken, Sato Chihiro

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 23 ( 9 )   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms23095207

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  12. Analysis of biochemical features of ST8 alpha-N-acetyl-neuraminide alpha 2,8-sialyltransferase (St8sia) 5 isoforms Reviewed International journal

    Araki Erino, Hane Masaya, Hatanaka Rina, Kimura Ryota, Tsuda Kana, Konishi Miku, Komura Naoko, Ando Hiromune, Kitajima Ken, Sato Chihiro

    GLYCOCONJUGATE JOURNAL   Vol. 39 ( 2 ) page: 291 - 302   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10719-021-10034-8

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  13. Lower promoter activity of the ST8SIA2 gene has been favored in evolving human collective brains Reviewed International journal

    Hayakawa Toshiyuki, Terahara Masahiro, Fujito Naoko T., Matsunaga Takumi, Teshima Kosuke M., Hane Masaya, Kitajima Ken, Sato Chihiro, Takahata Naoyuki, Satta Yoko

    PLOS ONE   Vol. 16 ( 12 )   2021.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0259897

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  14. A point-mutation in the C-domain of CMP-sialic acid synthetase leads to lethality of medaka due to protein insolubility Reviewed International journal

    Wu Di, Arakawa Hiromu, Fujita Akiko, Hashimoto Hisashi, Hibi Masahiko, Naruse Kiyoshi, Kamei Yasuhiro, Sato Chihiro, Kitajima Ken

    SCIENTIFIC REPORTS   Vol. 11 ( 1 )   2021.12

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-01715-3

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  15. Polysialylation and disease Invited Reviewed International journal

    Mol Aspects Med   Vol. 79   2021.6

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    DOI: 10.1016/j.mam.2020.100892

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  16. Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis

    Kawanishi Kunio, Saha Sudeshna, Diaz Sandra, Vaill Michael, Sasmal Aniruddha, Siddiqui Shoib S., Choudhury Biswa, Sharma Kumar, Chen Xi, Schoenhofen Ian C., Sato Chihiro, Kitajima Ken, Freeze Hudson H., Munster-Kuhnel Anja, Varki Ajit

    JOURNAL OF CLINICAL INVESTIGATION   Vol. 131 ( 5 )   2021.3

  17. The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid

    Yoshimura Atsushi, Hatanaka Rina, Tanaka Hiroshi, Kitajima Ken, Sato Chihiro

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 534   page: 1069 - 1075   2021.1

  18. Exploring the Impact of Ketodeoxynonulosonic Acid in Host-Pathogen Interactions Using Uptake and Surface Display by Nontypeable Haemophilus influenzae

    Saha Sudeshna, Coady Alison, Sasmal Aniruddha, Kawanishi Kunio, Choudhury Biswa, Yu Hai, Sorensen Ricardo U., Inostroza Jaime, Schoenhofen Ian C., Chen Xi, Munster-Kuhnel Anja, Sato Chihiro, Kitajima Ken, Ram Sanjay, Nizet Victor, Varki Ajit

    MBIO   Vol. 12 ( 1 )   2021

  19. Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells Reviewed International coauthorship International journal

    Yoshimura Atsushi, Asahina Yuki, Chang Lan-Yi, Angata Takashi, Tanaka Hiroshi, Kitajima Ken, Sato Chihiro

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 296   2021

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbc.2021.100477

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  20. The expression of sulfated sialic acids (SiaS) is dynamically regulated in mammalian cells

    Kitajima Ken, Ertunc Nursah, Sato Chihiro

    GLYCOBIOLOGY   Vol. 30 ( 12 ) page: 1066 - 1067   2020.12

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  21. Sialic acid sulfation is induced by the antibiotic treatment in mammalian cells

    Ertunc Nursah, Sato Chihiro, Kitajima Ken

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   Vol. 84 ( 11 ) page: 2311 - 2318   2020.11

  22. Comparative Studies of Polysialic Acids Derived from Five Different Vertebrate Brains

    Yang Yi, Murai Ryo, Takahashi Yuka, Mori Airi, Hane Masaya, Kitajima Ken, Sato Chihiro

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 21 ( 22 )   2020.11

  23. Combinational Analyses with Multiple Methods Reveal the Existence of Several Forms of Polysialylated Neural Cell Adhesion Molecule in Mouse Developing Brains

    Mori Airi, Yang Yi, Takahashi Yuka, Hane Masaya, Kitajima Ken, Sato Chihiro

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 21 ( 16 )   2020.8

  24. Systems glycomics of adult zebrafish Invited Reviewed International coauthorship

    Ken Kitajima, Nao Yamakawa, Chihiro Sato, Yann Guerardel

    Journal of Japanese Biochemical Society   Vol. 92 ( 3 ) page: 349 - 359   2020.6

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    Authorship:Lead author, Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.14952/SEIKAGAKU.2020.920349

  25. Discovery of a new sialic acid binding region that regulates Siglec-7

    Yamakawa Nao, Yasuda Yu, Yoshimura Atsushi, Goshima Ami, Crocker Paul R., Vergoten Gerard, Nishiura Yuji, Takahashi Takashi, Hanashima Shinya, Matsumoto Kana, Yamaguchi Yoshiki, Tanaka Hiroshi, Kitajima Ken, Sato Chihiro

    SCIENTIFIC REPORTS   Vol. 10 ( 1 )   2020.5

  26. Identification and characterization of a novel, versatile sialidase from a Sphingobacterium that can hydrolyze the glycosides of any sialic acid species at neutral pH

    Iwaki Yuya, Matsunaga Emiko, Takegawa Kaoru, Sato Chihiro, Kitajima Ken

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 523 ( 2 ) page: 487 - 492   2020.3

  27. Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice

    Ikegami Keisuke, Saigoh Kazumasa, Fujioka Atsuko, Nagano Mamoru, Kitajima Ken, Sato Chihiro, Masubuchi Satoru, Kusunoki Susumu, Shigeyoshi Yasufumi

    SCIENTIFIC REPORTS   Vol. 9   2019.9

  28. Functional roles of ST8SIA3-mediated sialylation of striatal dopamine D-2 and adenosine A(2A) receptors

    Lin Chien-Yu, Lai Hsing-Lin, Chen Hui-Mei, Siew Jian-Jing, Hsiao Cheng-Te, Chang Hua-Chien, Liao Kuo-Shiang, Tsai Shih-Chieh, Wu Chung-Yi, Kitajima Ken, Sato Chihiro, Khoo Kay-Hooi, Chern Yijuang

    TRANSLATIONAL PSYCHIATRY   Vol. 9   2019.8

  29. Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain

    Abe Chikara, Yi Yang, Hane Masaya, Kitajima Ken, Sato Chihiro

    SCIENTIFIC REPORTS   Vol. 9   2019.7

  30. Structural Diversity and Evolution of Sialic Acids

    Kitajima Ken

    TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY   Vol. 31 ( 181 ) page: SE18 - SE20   2019.7

  31. N-linked mannose glycoconjugates on shrimp thrombospondin, pmTSP-II, and their involvement in the sperm acrosome reaction

    Timklay Wauranittha, Magerd Sirilug, Sato Chihiro, Somrit Monsicha, Watthammawut Atthaboon, Senarai Thanyaporn, Weerachatyanukul Wattana, Kitajima Ken, Asuvapongpatana Somluk

    MOLECULAR REPRODUCTION AND DEVELOPMENT   Vol. 86 ( 4 ) page: 440 - 449   2019.4

  32. Sialic Acids in Neurology

    SIALIC ACIDS, PT II: BIOLOGICAL AND BIOMEDICAL ASPECTS   Vol. 76   page: 1 - 64   2019

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/bs.accb.2018.09.003

    Web of Science

  33. Technologies to Elucidate Functions of Glycans

    Furukawa Koichi, Ohmi Yuhsuke, Kondo Yuji, Ohkawa Yuki, Tajima Orie, Furukawa Keiko, Honke Koichi, Inokuchi Jin-ichi, Gu Jianguo, Kadomatsu Kenji, Nadanaka Satomi, Kitagawa Hiroshi, Nishihara Shoko, Nomura Kazuya, Oka Shogo, Ito Makoto, Kitajima Ken, Natsuka Shunji, Kanagawa Motoi, Ishimizu Takeshi, Fujiyama Kazuhito, Chiba Yasunori, Osada Hiroyuki

    GLYCOSCIENCE: BASIC SCIENCE TO APPLICATIONS: INSIGHTS FROM THE JAPAN CONSORTIUM FOR GLYCOBIOLOGY AND GLYCOTECHNOLOGY (JCGG)     page: 87 - 124   2019

  34. Sialic Acids in Neurology Invited Reviewed

    Sato C, Kitajima K

    Adv Carbohydr Chem Biochem   Vol. 76   page: 1 - 64   2019

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/bs.accb.2018.09.003

  35. Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns

    Yamakawa Nao, Vanbeselaere Jorick, Chang Lan-Yi, Yu Shin-Yi, Ducrocq Lucie, Harduin-Lepers Anne, Kurata Junichi, Aoki-Kinoshita Kiyoko F., Sato Chihiro, Khoo Kay-Hooi, Kitajima Ken, Guerardel Yann

    NATURE COMMUNICATIONS   Vol. 9   2018.11

  36. Positive selection on schizophrenia-associated ST8SIA2 gene in post-glacial Asia

    Fujito Naoko T., Satta Yoko, Hane Masaya, Matsui Atsushi, Yashima Kenta, Kitajima Ken, Sato Chihiro, Takahata Naoyuki, Hayakawa Toshiyuki

    PLOS ONE   Vol. 13 ( 7 )   2018.7

  37. ポリシアル酸化 Invited Reviewed

    佐藤ちひろ、北島健

    膜タンパク質; 特集 「タンパク質・核酸の分子修飾 Ⅲ. 細胞膜での分子修飾」)生体の科学   Vol. 69 ( 5 ) page: 502 - 503   2018

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    Authorship:Corresponding author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  38. Identification of KDN-Gangliosides

    Kitajima Ken

    GANGLIOSIDES: METHODS AND PROTOCOLS   Vol. 1804   page: 429 - 435   2018

  39. Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4

    Mori Airi, Hane Masaya, Niimi Yuki, Kitajima Ken, Sato Chihiro

    GLYCOBIOLOGY   Vol. 27 ( 9 ) page: 834-846   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/glycob/cwx057

    Web of Science

  40. Invisible glycoproteins with unusually high carbohydrate content in animal gametic cells

    Kitajima Ken

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   Vol. 254   2017.8

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  41. Chemical Synthesis and Evaluation of a Disialic Acid-Containing Dextran Polymer as an Inhibitor for the Interaction between Siglec 7 and Its Ligand

    Yamaguchi Sho, Yoshimura Atsushi, Yasuda Yu, Mori Airi, Tanaka Hiroshi, Takahashi Takashi, Kitajima Ken, Sato Chihiro

    CHEMBIOCHEM   Vol. 18 ( 13 ) page: 1194-1203   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cbic.201600694

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  42. Alpha-2 macroglobulin as a region-specific secretory protein in male reproductive tract, and its dynamics during sperm transit toward the female spermatheca in the blue crab

    Senarai Thanyaporn, Vanichviriyakit Rapeepun, Miyata Shinji, Sato Chihiro, Sretarugsa Prapee, Weerachatyanukul Wattana, Kitajima Ken

    MOLECULAR REPRODUCTION AND DEVELOPMENT   Vol. 84 ( 7 ) page: 585-595   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/mrd.22817

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  43. Chlorpromazine Increases the Expression of Polysialic Acid (PolySia) in Human Neuroblastoma Cells and Mouse Prefrontal Cortex Reviewed International journal

    Abe Chikara, Nishimura Saki, Mori Airi, Niimi Yuki, Yang Yi, Hane Masaya, Kitajima Ken, Sato Chihiro

    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   Vol. 18 ( 6 )   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/ijms18061123

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  44. Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation

    Go Shinji, Go Shiori, Veillon Lucas, Ciampa Maria Grazia, Mauri Laura, Sato Chihiro, Kitajima Ken, Prinetti Alessandro, Sonnino Sandro, Inokuchi Jin-ichi

    JOURNAL OF BIOLOGICAL CHEMISTRY   Vol. 292 ( 17 ) page: 7040-7051   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M116.771253

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  45. Diverse subcellular localizations of the insect CMP-sialic acid synthetases

    Di Wu, Fujita Akiko, Hamaguchi Kayo, Delannoy Philippe, Sato Chihiro, Kitajima Ken

    GLYCOBIOLOGY   Vol. 27 ( 4 ) page: 329-341   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/glycob/cww128

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  46. Synthesis of end-functionalized glycopolymers containing alpha(2,8) disialic acids via pi-allyl nickel catalyzed coordinating polymerization and their interaction with Siglec-7

    Ohira Shuichi, Yasuda Yu, Tomita Ikuyoshi, Kitajima Ken, Takahashi Takashi, Sato Chihiro, Tanaka Hiroshi

    CHEMICAL COMMUNICATIONS   Vol. 53 ( 3 ) page: 553-556   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c6cc07115e

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  47. Synthesis of End-functionalized Glycopolymers Containing α(2,8) Disialic Acids by π-Allyl Nickel Catalyzed Coordinating Polymerization and Their Interaction with Siglec-7.

    Ohira S, Yasuda Y, Tomita I, Kitajima K, Takahashi T, Sato C, Tanaka H.

      Vol. 53 ( 3 ) page: 553-556   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/C6CC07115E

  48. Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.

    Go S, Go S*, Veillon L, Ciampa MG, Mauri L, Sato C, Kitajima K, Prinetti A, Sonnino S, Inokuchi JI.

    J Biol Chem.     2017

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M116.771253

  49. Diverse subcellular localizations of the insect CMP-sialic acid synthetases

    Wu D, Fujita A, Hamaguchi K, Delannoy P, Sato C, Kitajima K.

        page: Epub ahead of print   2016.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/glycob/cww128

  50. Relationship between ST8SIA2, polysialic acid and its binding molecules, and psychiatric disorders.

    Sato C, Hane M, Kitajima K.

    Biochim Biophys Acta.   Vol. 1860 ( 8 ) page: 1739-1752   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbagen.2016.04.015

  51. The AMOR Arabinogalactan Sugar Chain Induces Pollen-Tube Competency to Respond to Ovular Guidance.

    Mizukami AG, Inatsugi R, Jiao J, Kotake T, Kuwata K, Ootani K, Okuda S, Sankaranarayanan S, Sato Y, Maruyama D, Iwai H, Garénaux E, Sato C, Kitajima K, Tsumuraya Y, Mori H, Yamaguchi J, Itami K, Sasaki N, Higashiyama T.

    Curr Biol.   Vol. 26 ( 8 ) page: 1091-1097   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.cub.2016.02.040)

  52. Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products.

    Hane M**, Kitajima K, Sato C.

    Biochem Biophys Res Commun   Vol. 478 ( 3 ) page: 1123-1129   2016

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2016.08.079

  53. Discovery, primary and crystal structures, and capacitation-related properties of a prostate-derived heparin-binding protein WGA16 from boar sperm.

    Garénaux E, Kanagawa M, Tsuchiyama T, Hori K, Kanazawa T, Goshima A, Chiba M, Yasue H, Ikeda A, Yamaguchi Y, Sato C, and Kitajima K.

    J. Biol. Chem.   Vol. 290 ( 9 ) page: 5484-5501   2015

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    DOI: 10.1074/jbc.M114.635268

  54. Protective effects of polysialic acid on proteolytic cleavage of FGF2 and ProBDNF/BDNF

    Hane M*, Matsuoka S**, Ono S**, Miyata S, Kitajima K, Sato C.

      Vol. 25 ( 10 ) page: 1112-1124   2015

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    DOI: 10.1093/glycob/cwv049

  55. Ganglioside contained in the neuronal tissue-enriched acidic protein of 22 kDa (NAP-22) fraction prepared from the detergent-resistant membrane microdomain of rat brain inhibits the phosphatase activity of calcineurin.

    Kobayashi Y, da Silva R, Kumanogoh H, Miyata S, Sato C, Kitajima K, Nakamura S, Morita M, Hayashi F, Maekawa S.

      Vol. 93 ( 9 ) page: 1462-1470   2015

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    DOI: 10.1002/jnr.23599

  56. Sulfatide-Hsp70 interaction promotes Hsp70 clustering and stabilizes binding to unfolded protein.

    Harada Y**, Sato C, and Kitajima K.

      Vol. 5 ( 2 ) page: 958-973   2015

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    DOI: 10.3390/biom5020958

  57. Rapid trimming of cell surface polysialic acid (polySia) by exovesicular sialidase triggers release of preexisting surface neurotrophin.

    Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OM, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K, and Sato C.

    J. Biol. Chem.   Vol. 290 ( 21 ) page: 13202-13214   2015

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    DOI: 10.1074/jbc.M115.638759

  58. Disialic, oligosialic and polysialic acids: distribution, functions and related disease Reviewed

    Sato C, Kitajima K

    Journal of Biochemistry   Vol. 154 ( 2 ) page: 115-136   2014.6

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    DOI: 10.1093/jb/mvt057

  59. Comparison of analytical methods to detect polysialic acid. Reviewed

    Nishimura S, Hane M, Niimi Y, Miyata S, Kitajima K, and Sato C

    Journal of Glycomics and Lipidomics   Vol. 4 ( 2 ) page: 113   2014

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    DOI: 10.4172/2153-0637.1000113

  60. Polysialic acid: Biosynthesis, novel functions and applications. Reviewed

    Colley K, Kitajima K, Sato C

    Critical Reviews in Biochemistry and Molecular Biology     page: 1-35   2014

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    DOI: doi:10.3109/10409238.2014.976606

  61. Interaction of 70-kDa heat shock protein with glycosaminoglycans and acidc glycopolymers. Reviewed

    Harada Y, Garenaux E, Nagatsuka T, Uzawa H, Nishida Y, Sato C, Kitajima K

    Biochem Biophys Res Commun.   Vol. 453   page: 229-234   2014

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    DOI: doi: 10.1016/j.bbrc.2014.05.137

  62. Identification of novel isoforms of vitellogenin expressed in ascidian eggs. Reviewed

    Akasaka M, Kato KH, Kitajima K, Sawada H.

    J Exp Zool Part B Mol Dev Evol.   Vol. 320 ( 2 ) page: 118-128   2013

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  63. Occurrence of free deaminoneuraminic acid (KDN)-containing complex-type N-glycans in human prostate cancers. Reviewed

    Yabu M, Korekane H, Takahashi H, Ohigashi H, Ishikawa O, Hatano K, Nonomura N, Sato C, Kitajima K, Miyamoto Y.

    Glycobiology   Vol. 26 ( 6 ) page: 634-642   2013

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    DOI: 10.1093/glycob/cws132

  64. Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid. Reviewed

    Ono S, Hane M, Kitajima K, Sato C.

    J Biol Chem.   Vol. 287 ( 6 ) page: 3710-3722   2012

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  65. Metabolism of Vertebrate Amino Sugars with N-glycolyl Groups: Resistance of α2-8-linked N-glycolylneuraminic Acid to Enzymatic Cleavage. Reviewed

    Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woods R, Varki A.

    J Biol Chem.   Vol. 287 ( 34 ) page: 28917-28931   2012

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    DOI: 28917-28931

  66. Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons. Reviewed

    Takahashi K, Mitoma J, Hosono M, Shiozaki K, Sato C, Yamaguchi K, Kitajima K, Higashi H, Nitta K, Shima H, Miyagi T.

    J Biol Chem.   Vol. 287 ( 18 ) page: 14816-14826   2012

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    DOI: 14816-14826

  67. Structural and functional impairments of polysialic acid (polySia)-neural cell adhesion molecule (NCAM) synthesized by a mutated polysialyltransferase of a schizophrenic patient. Reviewed

    Hane M, Sumida M, Kitajima K, Sato C

    Pure Appl Chem.   Vol. 84 ( 9 ) page: 1895-1906   2012

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    DOI: 1895-1906

  68. Sialome analysis of the cephalochordate Branchiostoma belcheri, a key organism for vertebrate evolution. Reviewed

    Guérardel Y, Chang LY, Fujita A**, Coddeville B, Maes E, Sato C, Harduin-Lepers A, Kubokawa K, Kitajima K.

    Glycobiology   Vol. 22 ( 4 ) page: 479-491   2012

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    DOI: 479-491

  69. Pig sperm membrane microdomains contain a highly glycosylated 15-25-kDa wheat germ agglutinin-binding protein. Reviewed

    Kasekarn W, Kanazawa T, Hori K, Tsuchiyama T, Xue L, Garénaux E, Kongmanas K, Tanphaichitr N, Yasue H, Sato C, Kitajima K.

    Biochem. Biophys. Res. Commun.   Vol. 426 ( 3 ) page: 356-362   2012

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    DOI: 356-362

  70. Novel regulation of fibroblast growth factor 2 (FGF2)-mediated cell growth by polysialic acid. Reviewed

    Ono, S., Hane, M., Kitajima, K., and Sato, C.

    J Biol Chem.   Vol. 287 ( 6 ) page: 3710-3722   2012

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  71. New function of polysialic acid and its involvement in neural activities. Invited Reviewed

    Sato, C., and Kitajima, K.

    Seikagaku   Vol. 83 ( 3 ) page: 189-196   2011.3

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  72. Structural and functional impairments of polysialic acid by a mutated polysialyltransferase found in schizophrenia Reviewed

    Isomura, R, Kitajima, K., and Sato, C.

    Journal of Biological Chemistry   Vol. 286 ( 24 ) page: 21535-21545   2011

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  73. New function of polysialic acid and its relationship to schizoprenia. Invited Reviewed

    Sato, C., and Kitajima, K.

    Trends Glycsci Glycotech   Vol. 23 ( 133 ) page: 221-238   2011

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  74. Mechanism regulating Ca2+-dependent mechanosensory behaviour in sea urchin spermatozoa. Reviewed

    Kambara, Y., Shiba, K., Yoshida, M., Sato, C., Kitajima, K., and Shingyoji, C.

    Cell Struct Funct   Vol. 36 ( 1 ) page: 69-82   2011

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  75. Co-expression of two distinct polysialic acids, α2,8- and α2,9-linked polymers of N-acetylneuraminic acid, in distinct glycoproteins and glycolipids in sea urchin sperm Reviewed

    Miyata, S., Yamakawa, N., Toritama, M., Sato, C., and Kitajima, K.

    Glycobiology   Vol. 21 ( 12 ) page: 1596-1605   2011

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  76. Extensive enrichment of N-glycolylneuraminic acid in extracellular sialoglycoproteins abundantly synthesized and secreted by human cancer cells. Reviewed

    Sadako Inoue, Chihiro Sato., and Ken Kitajima

    Glycobiology   Vol. 20   page: 752-762   2010

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  77. Survival signals of hepatic stellate cells in liver regeneration are regulated by glycosylation changes in rat vitronectin, especially decreased sialylation. Reviewed

    Kotone Sano, Yasunori Miyamoto, Nana Kawasaki, Noritaka Hashii, Satsuki Itoh, Misaki Murase, Kimie Date, Miki Yokoyama, Chihiro Sato, Ken Kitajima, and Haruko Ogawa

    J. Biol. Chem.   Vol. 285   page: 17301-17309   2010

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  78. Developmental stage-dependent expression of an α2,8- trisialic acid unit on glycoproteins in mouse brain. Reviewed

    Inoko, E., Nishiura, Y., Tanaka, H., Takahashi, T., Furukawa, K., Kitajima, K., and Sato, C.

    Glycobiology   Vol. 20   page: 916-928   2010

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  79. Human KDN (deaminated neuraminic acid) and its elevated expression in cancer cells: mechanism and significance. Reviewed

    Inoue, S., Kitajima, K., Sato, C., and Go, S.

    Adv Exp Med Biol   Vol. 705   page: 669-678   2010

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  80. *Membrane microdomains from early gastrula embryos of medaka, Oryzias latipes are a plat form of E-cadherin and carbohydrate-mediated cell-cell interactions during epiboly Reviewed

    Adachi T., Sato, C., Kishi, Y., Totani, K., Murata, T., Usui, T., and Kitajima, K

    Glycoconjugate J   Vol. 26   page: 285-99   2009

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  81. Complex formation of a brain-derived neurotrophic factor and glycosaminoglycans. Reviewed

    Kanato, Y., Ono, S., Kitajima, K. and Sato, C.

    Biosci. Biotech. Biosci.   Vol. 73   page: 2735-2741   2009

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  82. Developmental regulation of oligosialylation in zebrafish. Reviewed

    Chang LY, Harduin-Lepers A, Kitajima K, Sato C, Huang CJ, Khoo KH, Guérardel Y.

    Glycoconjugate J   Vol. 26   page: 247-61   2009

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  83. Direct binding of polysialic acid to a brain-derived neurotrphic factor depends on the degree of polymerization. Reviewed

    Kanato, Y., Kitajima, K. Sato, C.

    Glycobiology   Vol. 12   page: 1044-1053   2008

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  84. Identification of an inflammation-inducible serum protein recognized by anti-disialic acid antibodies as carbonic anhydrase II Reviewed

    Yasukawa, Z., Sato, C., and Kitajima, K.

    J. Biochem.   Vol. 141   page: 429-441   2007

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  85. Glycobiology of polysialic acids on sea urchin gametes Reviewed

    Miyata, S., Sato, C., and Kitajima, K.

    Trends Glycosci. Glycotech.   Vol. 19   page: 83-95   2007

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  86. *Membrane microdomain formation is crucial in epiboly during gastrulation of medaka. Reviewed

    Adachi, T., Sato, C., and Kitajima, K.

    Biochem. Biophys. Res. Commun.   Vol. 358   page: 848-853   2007

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    Membrane microdomain (microdomain) was isolated from early gastrula embryos. The isolated microdomain was characterized by enrichment of cholesterol and sphingomyelin and by the presence of huge glycoproteins containing Lewis X structure. Importance of the microdomain in the progress of epiboly was assessed using methyl β-cyclodextrin (MBCD) and C2-ceramide that disrupt microdomains through different mechanisms. Both reagents efficiently disrupted the microdomain structure, and concomitantly impaired epiboly. Interestingly, when embryos pretreated with MBCD, a cholesterol-binding molecule, were exogenously supplemented with cholesterol, the embryos undergo not only reconstitution of the microdomain, but also complete restoration to the normal epiboly. Thus, normal or impaired development is reversibly controlled by the cholesterol-dependent formation or disruption of microdomains. The most typical phenotype of the microdomain-disrupted embryos is detachment of cells from the blastoderm, suggesting that a major contribution of microdomains to epiboly is cell adhesion of blastodermal cells.

  87. Development of sensitive chemical and immunochemical methods for detecting sulfated sialic acids and their application to glycoconjugates from sea urchin sperm and eggs Reviewed

    Yamakawa, N., Sato, C., Miyata, S., Maehashi, E., Toriyama, M, Sato, N, Furuhata, K., and Kitajima, K.

    Biochimie   Vol. 89   page: 1396-1408   2007

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  88. *Hypoxia-enhanced expression of free deaminoneuraminic acid in human cancer cells Reviewed

    Go, S., Sato, C., Yin, J., Kannagi, R., and Kitajima, K.

    Biochem. Biophys. Res. Commun.   Vol. 357   page: 537-542   2007

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  89. *Identification of the nuclear export signals that regulate the intracellular localization of the mouse CMP-sialic acid synthetase Reviewed

    Fujita , A., Sato, C., and Kitajima, K.

    Biochem. Biophys. Res. Commun.   Vol. 355   page: 174-180   2007

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  90. Complex formation of 70-kDa heat shock protein with acidic glycolipids and phospholipids Reviewed

    Harada, Y., Sato, C., and Kitajima, K.

    Biochem. Biophys. Res. Commun.   Vol. 353   page: 655-660   2007

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  91. The rainbow trout CMP-sialic acid synthetase utilizes a nuclear localization signal different from that identified in the mouse enzyme. Reviewed

    Tiralongo J, Fujita A, Sato C, Kitajima K, Lehmann F, Oschlies M, Gerardy-Schahn R, Münster-Kühnel AK.

    Glycobiology   Vol. 17   page: 945-954   2007

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  92. Oral ingestion of mannose alters the expression level of deaminoneuraminic acid (KDN) in mouse organs Reviewed

    Go, S., Sato, C., and Kitajima, K.

    Glycoconjugate J.   Vol. 23   page: 409-419   2006

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  93. *Flagellasialin: a novel sulfated alpha2,9-linked polysialic acid glycoprotein of sea urchin sperm flagella Reviewed

    Miyata, S., Sato, C., Kumita, H., Toriyama, M., Vacquier, V. D., and Kitajima, K.

    Glycobology   Vol. 166   page: 1229-1241   2006

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    We previously demonstrated that the sea urchin, Hemicentrotus pulcherrimus, sperm flagellum glycoprotein with a diverse molecular weight of 40-80 kDa range was modified with a new type of polysialic acid structure, HSO3→8Neu5Acα2→9(Neu5Acα2→9)n-2Neu5Acα2→6GalNAcα1→Thr (n, on average 15) (Miyata et al. (2004) Glycobiology, 14, 827-840). In this study, we have purified the 40-80 kDa glycoprotein, designated flagellasialin, and cloned its cDNA. Flagellasialin is a 96-amino acid, threonine-rich, heavily O-glycosylated (80-90% by weight) glycoprotein with a single transmembrane segment, and is specifically expressed in testis. It was found that of 12 threonine residues in the extracellular region of flagellasialin, 8 residues were O-glycosylated and 3 residues were non-glycosylated confirmed by MALDI-TOF-MS and Edman degradation. The structure of flagellasialin from different sea urchin species, Strongylocentrotus purpuratus and Strongylocentrotus franciscanus, were also determined to ascertain if there were any species-specific differences in flagellasialin. The amino acid sequences of three flagellasialin were 100% identical. However, the core glycan structures and the proportions of polyNeu5Ac-containing O-glycans were different among three species. Finally, antisera against α2,9-linked polyNeu5Ac structure, which recognize flagellasialin, inhibited sea urchin fertilization and reduced sperm motility. All these results suggest that polysialylated flagellasialin is highly concerved among sea urchin and that α2,9-linked polysialic acid is involved in sperm activity in fertilization.

  94. KDN (Deaminated neuraminic acid): Dreamful past and exciting future of the newest member of the sialic acid family Reviewed

    Inoue, S. and Kitajima, K.

    Glycoconjugate J.   Vol. 23   page: 277-290   2006

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  95. Involvement of the alpha2,8-Polysialyltransferases II/STX and IV/PST in the Biosynthesis of Polysialic Acid Chains on the O-Linked Glycoproteins in Rainbow Trout Ovary Reviewed

    Asahina, S., Sato, C., Matsuno, M., Matsuda, T., Colley, K., and Kitajima, K.

    J. Biochem.   Vol. 140   page: 687-701   2006

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  96. Weaning-induced expression of a milk-fat globule protein, MFG-E8, in mouse mammary glands, as demonstrated by the analyses of its mRNA, protein and phosphatidylserine-binding activity Reviewed

    Nakatani, H., Aoki, N., Nakagawa, Y., Jin-No, S., Aoyama K, Oshima, K., Ohira, S., Sato, C., Nadano, D., Matsuda, T.

    Biochem J.   Vol. 395   page: 21-30   2006

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  97. Hypoxic culture induces expression of Sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells Reviewed

    Yin, J., Hashimoto, A., Izawa, M., Miyazaki, K., Chen G-Y., Takematsu, H., Kozutsumi, Y., Suzuki, A., Furuhata, K., Cheng, F.-L. Lin, C.-H., Sato, C., Kitajima, K., and Kannagi, R.

    Cancer Res.   Vol. 66   page: 2937-2945   2006

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  98. N-Linked oligosaccharides on chondroitin 6-sulfotransferase-1 are required for production of the active enzyme, golgi localization, and sulfotransferase activity toward keratan sulfate Reviewed

    Yusa, A., Kitajima, K., and Habuchi, O.

    J. Boil. Chem.   Vol. 281   page: 20393-20403   2006

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  99. Identification of disialic acid-containing glycoproteins in mouse serum: a novel modification of immunoglobulin light chains, vitronectin, and plasminogen Reviewed

    Yasukawa, Z., Sato, C., Sano, K., Ogawa, H. and Kitajima, K.

    Glycobiology   Vol. 166   page: 651-665   2006

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  100. Development of a simple and efficient method for assaying cytidine monophosphate sialic acid synthetase activity using an enzymatic reduced nicotinamide adenine dinucleotide/oxidized nicotinamide adenine dinucleotide converting system Reviewed

    Fujita, A., Sato, C., Munster-Kuhnel, A.-K., Gerardy-Schahn, R., and Kitajima, K.

    Anal. Biochem.   Vol. 337   page: 12-21   2005

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  101. Inflammation-dependent changes in α2,3-, α2,6-, and α2,8-sialic acid glycotopes on serum glycoproteins in mouse Reviewed

    Yasukawa, Z., Sato, C., and Kitajima, K.

    Glycobiology   Vol. 15   page: 827-837   2005

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  102. Distal myopathy with rimmed vaculoes: Impared O-glycan formation in muscular glycoproteins Reviewed

    Tajima, Y., Uyama, E., Go, S., Sato, C., Tao, N., Kotani, M., Hino, H., Suzuki, A., Sanai, Y., Kitajima, K., and Sakuraba, H.

    Amer. J. Pathol.   Vol. 166   page: 1121-1130   2005

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  103. Probing a CMP-Kdn synthetase by 1H, 31P and STD NMR spectroscopy Reviewed

    Haselhorst, T., Munster-Kuhnel, A.-K., Stolz, A., Oschlies, M., Tiralongo, J., Kitajima, K., Gerardy-Schahn, R., and von Itzstein, M.

    Biochem. Biophys. Res. Commun.   Vol. 327   page: 565-570   2005

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  104. N-linked oligosaccharides are required to produce and stabilize the active form of chondroitin 4-sulfotransferase-1 Reviewed

    Yusa, A., Kitajima, K., and Habuchi, O.

    Biochem. J.   Vol. 388   page: 115-121   2005

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  105. A major flagellum sialoglycoprotein in sea urchin sperm contains a novel polysialic acid, an α2,9-linked poly-N-acetylneuraminic acid chain, capped by an 8-O-sulfated sialic acid residue Reviewed

    Miyata, S., Sato, C., Kitamura, S., Toriyama, M.,and Kitajima, K.

    Glycobiology   Vol. 141   page: 827-840   2004

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  106. 受精・発生と糖鎖認識の研究における最近の発展 Reviewed

    北島健

    生化学   Vol. 76   page: 191-200   2004

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  107. Specificity of human trans-sialidase as probed with gangliosides. Reviewed

    Nikonova, E.Y., Tertov, V.V., Sato C, Kitajima K, and Bovin, N.V.

    Bioorg Med Chem. Lett.   Vol. 141   page: 5161-5164   2004

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  108. Alpha-C-Mannosyltryptophan is not recognized by conventional mannose-binding lectins Reviewed

    Nishikawa T, Kajii S, Sato C, Yasukawa Z, Kitajima K, and Isobe M.

    Bioorg Med Chem.   Vol. 12   page: 2343-2348   2004

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  109. Surface plasmon resonance study of carbohydrate-carbohydrate interaction between various gangliosides and Gg3-carrying polystyrene Reviewed

    Matsuura, K., Oda, R., Kitakouji, H., Kiso, M., Kitajima, K., and Kobayashi, K.

    Biomacromolecules   Vol. 5   page: 937-941   2004

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  110. A newly identified zona pellucida glycoprotein, ZPD, and domeric ZP1 of chicken egg envelope are involved in sperm activation on sperm-egg Reviewed

    Okumura, H., Khono, Y., Iwata, Y., Mori, H., Aoki, N., Sato, C., Kitajima, K., Nadano, D., and Matsuda, T.

    Biochem. J.   Vol. 384   page: 191-199   2004

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  111. Developmental expression of a sialyltransferase responsible for sialylation of cortical alveolus glycoprotein during oogenesis in rainbow trout (Oncorhynchus mykiss) Reviewed

    Asahina, S., Sato, C., and Kitajima, K.

    J. Biochem. (Tokyo)   Vol. 136   page: 189-198   2004

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  112. "A 33-kDa allergen from rice (Oryza sativa L. Japonica). cDNA cloning, expression, and identification as a novel glyoxalase I."

    "Usui, Y., Nakase, M., Hotta, H., Urisu, A., Aoki, N., Kitajima, K., and Matsuda, T."

    J. Biol. Chem.   Vol. 276   page: 11376-11381   2002.2

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  113. Molecular cloning of a unique CMP-sialic acid synthetase which effectively utilizes both deaminoneuraminic Acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates.

    "Nakata, D., Munster, A.-K., Gerardy-Schahn, R., Aoki, N., Matsuda, T., and Kitajima, K."

    Glycobiology   Vol. 11   page: 685-692   2001.1

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  114. Morphological and biochemical changes of isolated chicken egg-envelope during sperm penetration: Degradation of the 97 kilodalton glycoprotein is involved in sperm-driven hole formation on the egg-envelope.

    "Takeuchi, Y., Cho, R., Iwata, Y., Nishimura, K., Kato, T., Aoki, N., Kitajima, K., and Matsuda, T."

    Biology of Reproduction   Vol. 64   page: 822-830   2001.1

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  115. "Detection of di-, oligo-, and polysialic acid in glycoproteins."

    "Sato, C., Kitajima, K."

    Recent Research Developments in Analytical Biochemistry   Vol. "Transworld Research Network Publisher, India"   page: in press   2001.1

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    Language:English  

  116. "Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q."

    "Sato, C., Yasukawa, Z., Honda, N., Matsuda, T., and Kitajima, K."

    Journal of Biological Chemistry   Vol. 276   page: 28849-28856   2001.1

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  117. CA15. Oligosialic acid as a differentiation-associated antigen in human haemotoietic cell line HL60. Part 4 Carbohydrate and lectin.

    "Sato, C., Matsuda, T., and Kitajima, K."

    "Leucocyte typing VII (Mason et al., eds)"     page: in press   2001.1

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  118. CA3. Carbohydrate-recognizing monoclonal antibodies as revealed by ELISA using phosphatidylethanolamine-conjugated oligosacharides as antigens. Part 4 Carbohydrate and lectin.

    "Sato, C., Matsuda, T., and Kitajima, K."

    "Leucocyte typing VII (Mason et al., eds)"     page: in press   2001.1

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  119. Occurrence of oligosialic acids on integrin alpha-5 subunit and thier involvement in cell adhesion to fibronectin.

    "Nadanaka, S., Sato, C., Kitajima, K., Katagiri, K., Irie, S., and Yamagata, T."

    Journal of Biological Chemistry   Vol. 276   page: 33657-33664   2001.1

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  120. Carbohydrate-recognizing monoclonal antibodies as revealed by ELISA using phosphatidylethanolamine-conjugated oligosacharides as antigens.

    Leucocyte typing VII (Mason et al., eds), Oxford University Press     page: in press   2001

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  121. Occurrence of oligosialic acids on integrin alpha-5 subunit and thier involvement in cell adhesion to fibronectin.

    J. Biol. Chem.   Vol. 276   page: 33657-33664   2001

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  122. Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue-specific glycoprotein, adipo Q.

    J. Biol. Chem.   Vol. 276   page: 28849-28856   2001

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  123. Molecular cloning of a unique CMP-sialic acid synthetase which effectively utilizes both deaminoneuraminic acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates

    Glycobiology   Vol. 11   page: 685-692   2001

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  124. Detection of di-, oligo-, and polysialic acid in glycoproteins.

    Recent Research Developments in Analytical Biochemistry     page: in press   2001

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  125. Oligosialic acid as a differentiation-associated antigen in human haemotoietic cell line HL60.

    Leucocyte typing VII (Mason et al., eds), Oxford University Press     page: in press   2001

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  126. Morphological and biochemical changes of isolated chicken egg-envelope during sperm penetration: Degradation of the 97 kilodalton glycoprotein is involved in sperm-driven hole formation on the egg-envelope.

    Biol. Reprod.   Vol. 64   page: 822-830   2001

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  127. "Co-localization of receptor and transducer proteins in the glycosphingolipid-enriched, low density, detergent-insoluble membrane fraction of sea urchin sperm."

    "Ohta, K., Sato, C., Matsuda, T., Toriyama, M., Vacquier, V. D., Lennarz, W. J., and Kitajima, K."

    Glycoconjugate Journal   Vol. 17   page: 205-214   2000.1

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  128. "Frequent occurrence of pre-existing alpha2,8-linked disialic and oligosialic acids with chain lengths up to 7 Sia residues in mammalian brain glycoproteins. Prevalence revealed by highly sensitive chemical methods and anti-di-, oligo, and polysialic acid antibodies specific for defined chain lengths."

    "Sato, C., Fukuoka, H., Ohta, K., Matsuda, T., Koshino, R., Kobayashi, K., Troy, F. A. II,, and Kitajima, K."

    Journal of Biological Chemistry   Vol. 275   page: 15422-15431   2000.1

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  129. Lipid raft on gametic cells as a functional domain for sperm-egg interaction coupled with signal transduction.

    "Ohta, K., Sato, C., Matsuda, T., Toriyama, M., Vacquier, V. D., Hirohashi, N., Lennarz, W. J., and Kitajima, K."

    Zygote   Vol. 8 (Suppliment)   page: S56   2000.1

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  130. Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which has not the deaminoneuraminic acid (KDN) 9-phosphate synthase activity.

    "Nakata, D., Close, B. E., Colley, K. J., Matsuda, T., and Kitajima, K."

    Biochemical and Biophysical Research Communication   Vol. 273   page: 642-648   2000.1

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  131. 細胞間接着における糖鎖-糖鎖相互作用

    北島健

    "季刊「化学総説」季刊「化学総説」No. 48「糖鎖分子の設計と生理機能」日本化学会編,学会出版センター,pp.199-207"   Vol. "48「糖鎖分子の設計と生理機能」日本化学会編,学会出版センター"   page: pp.199-207   2000.1

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  132. Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which has not the deaminoneuraminic acid (KDN) 9-phosphate synthase activity.

    Biochem. Biophys. Res. Commun.   Vol. 273 ( 2 ) page: 642-648   2000

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  133. Co-localization of receptor and transducer proteins in the glycosphingolipid-enriched, low density, detergent-insoluble membrane fraction of sea urchin sperm.

    Glycoconjugate Journal   Vol. 17   page: 205-214   2000

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  134. Lipid raft on gametic cells as a functional domain for sperm-egg interaction coupled with signal transduction.

    Zygote   Vol. 8   page: S56   2000

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  135. Frequent occurrence of pre-existing alpha-2,8-linked disialic and oligosialic acids with chain lengths up to 7 Sia residues in mammalian brain glycoproteins: Prevalence revealed by highly sensitive chemical methods and anti-di-, oligo, and polysialic acid antibodies specific for defined chain lengths.

    J. Biol. Chem.   Vol. 275   page: 15422-15431   2000

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  136. 細胞間接着における糖鎖-糖鎖相互作用

    季刊化学総説「糖鎖分子の設計と生理機能」   Vol. 48   page: 199-207   2000

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  137. "A 42-kDa glycoprotein from chicken egg-envelope, an avian homolog of the ZPC family glycoproteins in mammalian zona pellucida. Its first identification, cDNA cloning and granulosa cell-specific expression."

    "Takeuchi, T., Nishimura, K., Aoki, N., Adachi, T., Sato, C., Kitajima, K., and Matsuda, T."

    European Journal of Biochemistry   Vol. 273   page: 21526-21530   1999.1

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  138. Glycobiology of di and oligosialyl glycotopes.

    "Sato, C., and Kitajima, K."

    Trends in Glycoscience Glycotechnology   Vol. 11   page: 371-390   1999.1

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  139. Lactation-dependent expression of an mRNA splice variant with an exon for a multiply O-glycosylated domain of mouse milk fat glubule glycoprotein MFG-E8.

    "Oshima, K., Aoki, N., Negi, M., Kishi, M., Kitajima, K., and Matsuda, T."

    Biochemical and Biophysical Research Communication   Vol. 254   page: 522-528   1999.1

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  140. Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and Characterization of a KDN-9-phosphate Synthetase Activity from Trout Testis.

    "Angata, T., Nakata, D., Matsuda, T., Kitajima, K., and Troy, F. A. II"

    Journal of Biological Chemistry   Vol. 274   page: 22949-22956   1999.1

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  141. Identification of two discrete peptide:N-glycanases in Oryzias latipes during embryogenesis.

    "Seko, A., Kitajima, K., Iwamatsu, T., Inoue, S., and Inoue, Y."

    Glycobiology   Vol. 9   page: 887-895   1999.1

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  142. Elevated expression of free deaminoneuraminic in mammalian cells cultured in mannose-rich media.

    "Angata, T., Nakata, D., Matsuda, T., and Kitajima, K."

    Biochemical and Biophysical Research Communication   Vol. 261   page: 326-331   1999.1

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  143. Fluorescent-assisted detection of oligosialyl units glycoconjugates.

    "Sato, C., Inoue, S., Matsuda, T., and Kitajima, K.,"

    Analytical Biochemistry   Vol. 266   page: 102-109   1999.1

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  144. Fluorescent-assisted detection of oligosialyl units in glycoconjugates.

    "Sato, C., Inoue, S., Matsuda, T., and Kitajima, K."

    Analytical Biochemistry   Vol. 267   page: 102-109   1999.1

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  145. Occurrence of a2ョ8-linked oligosialic acid residues in mammalian glycoproteins.

    "Kitajima, K., Sato, C., Honda, N., Matsuda, T., Yokoyama, M.-H., Close, B. E., and Colley, K. J."

    Sialobiology and Other novel Form of Glycosylation   Vol. "a monograph (Inoue, Y., Lee, Y. C., and Troy, F. A., eds), , Gakushin Syuppan, Osaka, Japan"   page: pp.69-76   1999.1

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  146. Isolation and characterization of low density detergent-insoluble membrane (LD-DIM) fraction from sea urchin sperm.

    "Ohta, K., Sato, C., Matsuda, T., Toriyama, M., Lennarz W. J., and Kitajima, K."

    Biochemical and Biophysical Research Communication   Vol. 258   page: 616-623   1999.1

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  147. Cholesterol-dependent localization of NAP-22 on a neuronal membrane microdomain (Raft).

    "Maekawa, S., Sato, C., Kitajima, K., Kumanogoh, H., Funatsu, N., and Sokawa, Y."

    Journal of Biological Chemistry Biological   Vol. 274   page: 21369-21374   1999.1

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  148. Biosynthesis of KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid). Identification and characterization of a KDN-9-phosphate synthetase activity from trout testis.

    J. Biol. Chem.   Vol. 274   page: 22949-22956   1999

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  149. Lactation-dependent expression of an mRNA splice variant with an exon for a multiply O-glycosylated domain of mouse milk fat glubule glycoprotein MFG-E8.

    Biochem. Biophys. Res. Commun.   Vol. 254   page: 522-528   1999

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  150. Cholesterol-dependent localization of NAP-22 on a neuronal membrane microdomain (Raft).

    J. Biol. Chem.   Vol. 274   page: 21369-21374   1999

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  151. Identification of two discrete peptide:N-glycanases in Oryzias latipes during embryogenesis.

    Glycobiology   Vol. 9   page: 887-895   1999

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    Language:English  

  152. Elevated expression of free deaminoneuraminic in mammalian cells cultured in mannose-rich media.

    Biochem. Biophys. Res. Commun.   Vol. 261   page: 326-331   1999

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    Language:English  

  153. Fluorescent-assisted detection of oligosialyl units in glycoconjugates.

    Analytical Biochemistry   Vol. 266   page: 102-109   1999

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    Language:English  

  154. A 42-kDa glycoprotein from chicken egg-envelope, an avian homolog of the ZPC family glycoproteins in mammalian zona pellucida. Its first identification, cDNA cloning and granulosa cell-specific expression.

    Eur. J. Biochem.   Vol. 273   page: 21526-21530   1999

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    Language:English  

  155. Isolation and characterization of low density detergent-insoluble membrane (LD-DIM) fraction from sea urchin sperm.

    Biochem. Biophys. Res. Commun.   Vol. 258   page: 616-623   1999

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    Language:English  

  156. Glycobiology of di and oligosialyl glycotopes.

    Trends Glycosci. Glycotechnol.   Vol. 11   page: 371-390   1999

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  157. A method for determination of UDP-GlcNAc: GlcNAcβ1-6(GlcNAcβ1-2)Man1-R[GlcNAc to Man] β1-4N-acetylglucosaminyl transferase VI activity using a pyridylaminated tetraantennary oligosaccharide as an acceptor substrate.

    "Taguchi, T., Ogawa, T., Kitajima, K., Inoue, S., Inoue, Y., Ihara, Y., Sakamoto, Y., Nagai, K., and Taniguchi, N.,"

    Analytical Biochemistry   Vol. 255   page: 155-157   1998.1

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  158. "Cloning a expression of an α-2,8-polysialyltransferase (STX) from Xenopus laevis."

    "Kudo, M., Takayama, E., Tashiro, K., Fukamachi, H., Nakata, T., Tadakuma, T., Kitajima, K., Inoue, Y., and Shiokawa, K.,"

    Glycobiology   Vol. 8   page: 771-777   1998.1

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  159. Avian egg coat glycoproteins: identification and characterization of homologues of mammalian zona pellucida glycoproteins.

    "Matsuda, T., Nishimura, K., Tsuda, T., Takeuchi, Y., Adachi, T., Aoki, N., and Kitajima, K."

    Zygote   Vol. 6   page: S80-S81   1998.1

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  160. "Iuction of KDNase Sm, a deaminoneuraminic acid (KDN) residue-specific sialidase from Sphingobacterium multivorum, using synthetic KDN-glycosides."

    "Fuchizawa, S., Furuhata, K., Matsuda, T., and Kitajima, K.,"

    Biochemical and Biophysical Research Communication   Vol. 248   page: 505-510   1998.1

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  161. Peptides glycosylated in the eoplasmic reticulum of yeast are subsequently deglycosylated by a soluble peptide N-glycanase activity.

    "Suzuki, T., Park, H., Kitajima, K., and Lennarz, W. J.,"

    Jorunal of Biological Chemistry   Vol. 273   page: 21526-21530   1998.1

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  162. "Development of a highly sensitive chemical method to detect α-2,8-linked oligo/polysialic acid residues in glycoproteins blotted on the membrane."

    "Sato, C., Inoue, S., Matsuda, T., and Kitajima, K.,"

    Anal. Biochemistry   Vol. 261   page: 191-197   1998.1

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  163. Identification of oligo-N-glycolylneuraminic acid residues in mammal-derived glycoproteins by a newly developed immunochemical reagent a biochemical methods.

    "Sato, C., Kitajima, K., Inoue, S., and Inoue, Y.,"

    Jounal of Biological Chemistry   Vol. 273   page: 2575-2582   1998.1

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  164. "Synthesis of neoglycoconjugates containing deaminated neuraminic acid (KDN) using rat liver α2,6-sialyltransferase."

    "Angata, T., Matsuda, T., and Kitajima, K.,"

    Glycobiology   Vol. 8   page: 277-284   1998.1

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  165. 新しいシアル酸KDNの糖鎖科学の現状と展望

    北島健

    バイオサイエンスとインダストリー   Vol. 56   page: 659-664   1998.1

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  166. "Structure and physiological activities of hyosophorin, a major cortical alveolus glycoprotein of fish eggs."

    "Kitajima, K., Taniguchi, J., Nakase, M., Kageyama, M., Matsuda, T., Sakagami, H., Inoue, S., and Inoue, Y."

    Zygote   Vol. 6   page: S6-S7   1998.1

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  167. Development of an enzyme-linked immunoadsorbent assay- based method for measuring galactosyltransferase activity using a synthetic glycopolymer acceptor substrate.

    "Oubihi, M., Kitajima, K., Kobayashi, K., Adachi, T., Aoki, N., and Matsuda, T.,"

    Analytical Biochemistry   Vol. 257   page: 169-175   1998.1

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  168. Identification of oligo-N-glycolylneuraminic acid residues mammal-derived glycoproteins by a newly developed immunochemical reagent and biochemical methods.

    J. Biol. Chem   Vol. 273   page: 2575-2582   1998

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  169. Induction of KDNase Sm, a deaminoneuraminic acid(KDN)residue-specific sialidase from Sphingobacterium multivorum, using synthetic KDN-glycosides.

    Biochem. Biophys. Res. Commun.   Vol. 248   page: 505-510   1998

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  170. 動物細胞におけるデアミノノイラミン酸(KDN)の生合成経路およびKDN複合糖質の発現の調節機構の解析

    生化学   Vol. 70   page: 607   1998

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  171. Avian egg coat glycoproteins : identification and characterzation of homologues of mammalian zona pellucida glycoproteins.

    Zygote   Vol. 6   page: S80-S81   1998

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  172. Present status and perspectives in research on a novel sialic acid, KDN.

    Bioscience and Industry   Vol. 56   page: 659-664   1998

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  173. Development of an enzyme-linked immunosorbent assay(ELISA)-based method for measuring galactosyltrasferase activity using a synthetic glycopolymer acceptor substrate.

    Anal. Biochem. ,   Vol. 257   page: 169-175   1998

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  174. A method for determination of UDP-Glc NAc : GlcNAcβ1-6(GlcNAc(β1-2)Manα1-R[GlcNAc to Man]β 1-4 N-acetylglucosaminyltransferase (]G0006[) activity using a pyridylaminated tetraantennary oligosaccharide as an acceptor substrate.

    Anal. Biochem. ,   Vol. 255   page: 155-157   1998

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    Language:English  

  175. Cloning and expression of an α2,8-polysialyltransferase(STX)from Xenopus aevis.

    Glycobiology   Vol. 8   page: 771-777   1998

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    Language:English  

  176. Development of a highly sensitive chemical method to detect α2→8-linked oligo/polysialic acid residues in glycoproteins blotted on the membrane.

    Anal. Biochem.   Vol. 261   page: 191-197   1998

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  177. Structure and physiological activities of hyosophorin, a major cortical alveolus glycoprotein of fish eggs.

    Zygote   Vol. 6   page: S6-S7   1998

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  178. Synthesis of neoglycoconjugates containing deaminated neuraminic acid(KDN)using rat liver α2,6-sialytransferase.

    Glycobiology   Vol. 8   page: 277-284   1998

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  179. Peptides glycosylated in the endoplasmic reticulum of yeast are subsequently deglycosylated by a soluble peptide : N-glycanase activity.

    J. Biol. Chem. ,   Vol. 273   page: 21526-21530   1998

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  180. Activity of UDP-GlcNAc: GlcNAcβ1-6(GlcNAcβ1-2)Man1-R[GlcNAc to Man]β1-4-N-acetyl glucosaminyl transferase VI(GnT VI) from the ovaries of Oryzias latipes (Medaka fish).

    "Taguchi, T., Kitajima, K., Inoue, S., Inoue, Y., Yang, J.-M., Schachter, H., and Brockhausen, I.,"

    Biochemical and Biophysical Research Communication   Vol. 230   page: 533-536   1997.1

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  181. "Catalysis by a new sialidase, deaminoneuraminic acid residue-cleaving enzyme (KDNase Sm), initially forms a less stable α-anomer of 3-deoxy-D-glycero-D-galacto-nononic acid a is strongly inhibited by the transition state analogue, 2-deoxy-2,3-dide hydro-D-glycero-D-galacto-2-nonulosonic acid, but not by 2-deoxy-2,3-didehydro-N-acetylneuraminic acid."

    "Terada, T., Kitajima, K., Inoue, S., Wilson, J. C., Norton, A. K., Kong, D. C. M., Thomson, R. J., von Itzstein, M., and Inoue, Y.,"

    Jornal of Biological Chemistry   Vol. 272   page: 5452-5456   1997.1

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  182. "Occurrence of terminal α2,8-linked disialylated poly-N-acetyllactosamine chains with LeX a I antigenic glycotopes in tetraantennary arms of an N-linked glycoprotein isolated from rainbow trout ovarian fluid."

    "Funakoshi, Y., Taguchi, Y., Sato, C., Kitajima, K., Inoue, S., Morris, H. R., Dell, A., and Inoue, Y.,"

    Glycobiology   Vol. 7   page: 195-205   1997.1

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  183. Combined chemical a enzymatic synthesis of a C-glycopeptide a its inhibitory activity toward glycosaminidases.

    "Wang, L.-X., Tang, M., Suzuki, T., Kitajima, K., Inoue, Y., Inoue, S., Fan, J.-Q., and Lee, Y. C.,"

    Jorunal of American Chemical Society   Vol. 119   page: 11137-11146   1997.1

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  184. KDN:ユニークなシアル酸の世界(Recent Advances in KDN Glycoscience)

    北島健

    バイオインダストリー   Vol. 14   page: 11-21   1997.1

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  185. Site-sepcific de-N-glycosylation of diglycosylated ovalbumin in hen oviduct by eogenous peptide: N-glycanase as a quality control system for newly synthesized proteins.

    "Suzuki, T., Kitajima, K., Emori, Y., Inoue, Y., and Inoue, S.,"

    Proc. Natl. Acad. Sci. USA   Vol. 94   page: 6244-6249   1997.1

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  186. 新しいシアル酸KDNの糖鎖生物学の最近の発展(Recent advances in glycobiology on KDN-containing glycoconjugates)

    北島健、井上貞子、井上康男

    生化学   Vol. 68   page: 44-51   1997.1

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  187. "Proton NMR study of triantennary complex type N-linked glycan chains: assignment of protein chemical shifts of the β-Man residue in a basic unit of the triantennary glycan chain having a GlcNAcβ1,6Manα1,6Manβ1-sequence."

    "Taguchi, T., Muto, Y., Kitajima, K., Yokoyama, S., Inoue, S., and Inoue, Y.,"

    Glycobiology   Vol. 7   page: 31-36   1997.1

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  188. Recent advances in glycobiology on KDN-containing alycoconjugates(共著)

    Seikagaku   Vol. 69 ( 1 ) page: 44-51   1997

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  189. Activity of UDP-GlcNAc : GlcNAcβ1→6(GlcNAcβ1→2)Man α1→R[GlcNAc to Man]β1→4N-acetylglucosaminyl-transferase Vl(GnT Vl)from The ouaries of Oryzias latibes(Medake fish)(共著)

    Biochem. Biophys. Res. Commun.   Vol. 230   page: 533-536   1997

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  190. Proton NMR study of triantennary complex type N-linked glycan chains : assignment of proton chemical shifts of the β-Man residue in a basic unit of the triantennary glycan chain having a GlcNAc β1→6Man α1→6Man β→Sequence(共著)

    Glycobiology   Vol. 7 ( 1 ) page: 31-36   1997

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  191. Site-specific de-N-glycosylation of diglycosylated ovalbumin in hen oviduct byendogenous PNG ase as a quality control systemfor newly synthesized proteins(共著)

    Proc. National Academy of Science   Vol. 94   page: 6244-6249   1997

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  192. Catalysis by a new sialidase, deaminoneuraminic acid residue-cleaving enzyme(KDNase Sm), initially forms a less stable α-arromer of KDN and is strongly in kibited by the transition-state analogue, KDN2en, but not Neu5 Ac2en. (共著)

    The Journal of Biological Chemistry   Vol. 272 ( 9 ) page: 5452-5456   1997

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  193. Recent advances in KDN glycosciences

      Vol. 14 ( 8 ) page: 11-21   1997

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  194. 糖タンパク質における新しいシアル酸含有糖鎖構造とその機能

    日本農芸化学会誌   Vol. 72   page: 452   1997

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  195. "Characterization of the major core structures of the α2,8-linked polysialic acid-containing glycan chains present in neural cell adhesion molecule (N-CAM) in embryonic chick brains."

    "Kudo, M., Kitajima, K., Inoue, S., Shiokawa, K., Morris, H. R., Dell, A., and Inoue, Y.,"

    Jorunal of Biological Chemistry   Vol. 271   page: 326667-32677   1996.1

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  196. Occurrence a precise structural analysis of highly sulfated multiantennary N-linked glycan chains derived from a fertilization-associated carbohydrate-rich glycoprotein in unfertilized eggs of Tribolodon hakonensis.

    "Taguchi, T., Iwasaki, M., Muto, Y., Kitajima, K., Inoue, S., Khoo, K.-H., Morris, H. R., Dell, A., and Inoue, Y.,"

    European Jornal of Biochemistry   Vol. 238   page: 357-367   1996.1

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  197. Isolation a identification of novel sulfated a nonsulfated oligosialyl glycosphingolipids from sea urchin sperm.

    "Ijuin, T., Kitajima, K., Yu, S., Kitazume, S., Inoue, A., Haslam, S. M., Morris, H. R., Dell, A., and Inoue, Y.,"

    Glycoconjugate Journal   Vol. 13   page: 401-413   1996.1

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  198. "The occurrence of novel 9-O-sulfated N-glycolylneuraminic acid-cappedα2,5-Oglycolyl-linked oligo/polyNeu5Gc chains in sea urchin egg cell surface glycoprotein. Identification of a new chain termination signal for polysialyltransferase."

    "Kitazume, S., Kitajima, K., Inoue, S., Haslam, S. M., Morris, H. R., Dell, A., Lennarz, W. J., and Inoue, Y.,"

    Jornal of Biological Chemistry   Vol. 271   page: 6694-6701   1996.1

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  199. "Occurrence of poly α2,8 deaminoneuraminic acid (KDN) in mammalian tissues: Widespread a developmentally-regulated but highly selective expression on glycoproteins."

    "Ziak, M., Qu, B., Zuo, X., Zuber, C., Kanamori, A., Kitajima, K., Inoue, S., Inoue, Y., and Roth, J.,"

    Proc. Natl. Acad. Sci. U.S.A.   Vol. 93   page: 2759-2763   1996.1

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  200. "Iuction, localization, a purification of a novel sialidase, deaminoneuraminidase (KDNase), from Sphingobacterium multivorum."

    "Nishino, S., Kuroyanagi, H., Terada, T., Inoue, S., Inoue, Y., Troy, F. A., II, and Kitajima, K.,"

    Journal of Biological Chemistry   Vol. 271   page: 2909-2913   1996.1

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  201. Structure and function of N-glycosylated glycoprotein in fish eggs and embryos.

    "Kitajima, K."

    Nippon Suisan Gakkaishi   Vol. 62   page: 289-290   1996.1

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  202. "Identification of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN, deaminoneuraminic acid) residues in mammalian tissues a human lung carcinoma cells. Chemical evidence of the occurrence of KDN glycoconjugates in mammals."

    "Inoue, S., Kitajima, K., and Inoue, Y.,"

    Journal of Biological Chemistry   Vol. 271   page: 24341-24344   1996.1

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  203. Substrate specificity of rainbow trout testis CMP-KDN synthetase. Kinetic studies of the CMP-KDN synthetase-catalyzed reaction of natural a synthetic analogues of nonulosonic acid.

    "Terada, T., Kitajima, K., Inoue, S., Koppert, K., Brossmer, R., and Inoue, R.,"

    European Journal of Biochemistry   Vol. 236   page: 852-855   1996.1

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  204. Identification of 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid(KDN, deaminoneuraminic acid)residues in mammalian tissues and human lung carcinoma cells. (共著)

    The Journal of Biological Chemistry   Vol. 271 ( 40 ) page: 24341-24344   1996

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  205. Induction, localization, and purification of a novel sialidase, deaminoneuraminidase (KDNase), from Sphingobocteriun multivorum.

    The Journal of Biological chemistry   Vol. 271 ( 6 ) page: 2909-2913   1996

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  206. Characterization of the major core structures of the α2→8-linked polysialic acid-containing glycan chains present in neural cell adhesion molecule in embryonic chick brains. (共著)

    The Journal of Biological Chemistry   Vol. 271 ( 51 ) page: 32667-32677   1996

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  207. Isolation and identification of novel sulfated and nonsulfated oligosialyl glycosphingolipids from sea urchin sperm.

    Glycoconjugate Journal   Vol. 13 ( 3 ) page: 401-413   1996

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  208. Substrate specificity of rainbow trout testis CMP-3-deoxy-D-glycero-D-galaeto-noncelosonic acicl (CMP-Kdn) synthe tase. Kinetic studies of the reaction of natural and synthetic analogues of ncnulosonic acid catalyzed by CMP-Kdn syuthefase.(共著)

    European Journal of Biochemistry   Vol. 236   page: 852-855   1996

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  209. Occurrence of poly(α2,8-deamino neuraminic acid) in mammalian tissues: widespread and developmentally regulated but highly selective expression on glycoprotoins.(共著)

    Proclaim of National Academy of Science, U.S.A.   Vol. 93   page: 2759-2763   1996

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  210. Structure and function of N-glycosylatecl glycoprotein in fish eggs and embryos.

    Nippon Suisan Gakkaishi   Vol. 62 ( 2 ) page: 289-290   1996

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    Language:English  

  211. The occurrence of novel 9-O-Sulfated N-glycolylneuraminic acid-capped α2→5-Oglycolyl-limked oligo/poly Neu5Gc chains in Sea urchin egg cell surface glycoprotein. Identification of a new chain termination signal for polysialyltransferse.(共著)

    The Journal of Biological Chemistry   Vol. 271 ( 12 ) page: 6694-6701   1996

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  212. Occurrence and structural analysis of highly sulfated multiantennary N-lmked glycan chains derived from a fertilization-associated carbohydrate-rich glycoprotein in unfertilized eggs of Tribolodon hakonensis. (共著)

    European Journal of Biochemistry   Vol. 238   page: 357-367   1996

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  213. Expression of new KDN-gangliosides in rainbow trout testis during spermatogenesis a their structural identification.

    "Yu, S., Kitajima, K., Inoue, S., Khoo, K.-H., Morris, H. R., Dell, A., and Inoue, Y.,"

    Glycobiology   Vol. 5   page: 207-218   1995.1

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  214. A precise structural analysis of a fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of euryhaline killi fish (Fuulus heteroclitus). Novel pentaantennary N-glycan chains with a bisecting N-acetylglucosaminyl residue.

    "Taguchi, T., Kitajima, K., Muto, T., Inoue, S., Khoo, K.-H., Morris, H. R., Dell, A., Wallace, R. A., Selman, K., and Inoue, Y.,"

    Glycobiology   Vol. 5   page: 611-624   1995.1

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  215. Complete assignment of carbon-13 NMR resonances to all the carbon atoms of the trimannosido-di-N-acetylchitobiosyl structure in a pentaantennary decasaccharide glycopeptide.

    "Taguchi, T., Kitajima, K., Niimi, T., Muto, Y., Yokoyama, S., Inoue, S., and Inoue, Y.,"

    Carbohydr. Res.   Vol. 275   page: 185-191   1995.1

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  216. N-Glycosylation/deglycosylation as a mechanism for the post-translational modification/remodification of proteins.

    "Suzuki, T., Kitajima, K., Inoue, S., and Inoue, Y.,"

    Glycoconjugate Journal   Vol. 12   page: 183-193   1995.1

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  217. "Characterization of the antigenic specificity of four different anti-(α2,8-linked polysialic acid) antibodies using lipid-conjugated oligo/polysialic acids."

    "Sato, C., Kitajima, K., Inoue, S., Seki, T., Troy, F. A., II, and Inoue, Y.,"

    Journal of Biological Chemistry   Vol. 270   page: 18923-18928   1995.1

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  218. Identification a distribution of peptide: N-glycanase (PNGase) in mouse organ.

    "Kitajima, K., Suzuki, T., Kouchi, Z., Inoue, S., and Inoue, Y.,"

    Arch. Biochem. Biophys.   Vol. 319   page: 393-401   1995.1

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  219. Carbohydrate-biing property of peptide: N-glycanase (PNGase) from mouse fibroblast L-929 cells as evaluated by inhibition a biing experiments using various oligosaccharides.

    "Suzuki, T., Kitajima, K., Inoue, S., and Inoue, Y.,"

    Journal of Biological Chemistry   Vol. 270   page: 15181-15186   1995.1

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  220. Proton NMR study of the trimannosyl unit in a pentaantennary N-linked decasaccharide structure. Complete assignment of the proton resonances a conformational characterization.

    "Taguchi, T., Kitajima, K., Muto, Y., Yokoyama, S., Inoue, S., and Inoue, Y.,"

    European Jornal of Biochemistry   Vol. 288   page: 822-829   1995.1

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  221. A precise structural analysis of a fertilization-associated carbohydrate-rich glycopeptide isolated from the fertilized eggs of euryhaline killi fish (Fundulus heteroclitus). Novel qenta-antennary N-glycar chains coith a bisecting N-acetylqlucosampyl residel,

    Glycobiology   Vol. 5 ( 6 ) page: 611-624   1995

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  222. Proton NMR study of the triomannosyl unit in a pentaanternary N-linked decasaccharide structure (共著)

    European Journal of Biochemistry   Vol. 228   page: 822-829   1995

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  223. Complete assignments of BC NMR resonance to all the carbon atoms of the trimannosido-di-N-acetylchitobiosyl structure in a pentaantennary decusaccharide glycopepticle.(共著)

    Carbohyclrate Researoh   Vol. 275   page: 185-191   1995

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  224. I dentification and distribution of peptide: N-glycanase (PNGose) in mouse organs.

    Archives of Biochemistry and Bioplcysics   Vol. 319 ( 2 ) page: 393-401   1995

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  225. Carbohydrate-binding property of peptide: N-glyecanase from mouse fibroblast L-929 cells as evaluated by inhibition and binding experiments using various oligosaccharides.

    The Journal of Biological Chemistry   Vol. 270 ( 25 ) page: 15181-15186   1995

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  226. Characterization of the antigenic specificity of four different anti(α2→8-linked polysialit acid) antibodies using lipid- conjugated oligo/polysialic acids.(共著)

    The Journal of Biologicol chemistry   Vol. 270 ( 32 ) page: 18923-18928   1995

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  227. Expression of new KDN-gangliosides in rainbow trout testis during spermatogenesis and their structural identification (共著)

    Glycobiology   Vol. 5 ( 2 ) page: 207-218   1995

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  228. N-Glycosylation/deglycosylation as a mechanism for the post-translational modification/remodification of proteins(共著)

    Glycoconjugate Journal   Vol. 12 ( 1 ) page: 183-193   1995

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  229. Discovery of a New type of sialidase, "KDN ase, " which specifically hydrolyzes deamironeuraminyl (3-deoxy-D-glycero-D-galacto-2-nonulosonic acid) but not N-acylneuraminyl linkages

    The Journal of Biological Chemistry   Vol. 269 ( 34 ) page: 21415-21419   1994

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  230. Occurrence and biological roles of 'proximal glycanases' in animal cells (共著)

    Glycobiology   Vol. 4 ( 6 ) page: 777-789   1994

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  231. Calcium ion binding of three different types of oligo/polysialic acids as studied by equilibrium dialysis and circular dichroic methods (共著)

    Biochemistry   Vol. 33 ( 5 ) page: 1202-1208   1994

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  232. Identification and structural determination of the KDN-containing N-linked glycan chains consisting of bi-and tri-dntennary complex-type units of KDN-glycoprotin previously isolated from rainbow trout vitelline envelopes (共著)

    Biochemistry   Vol. 33 ( 21 ) page: 6495-6502   1994

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  233. Differential reactivity of two types of N-ghycolylneuraminic acid dimers toward enzymatic and nonenzymatic hydrolysis of their interketosidic linkages (共著)

    Biochemical and Biophysical Research Communication   Vol. 205 ( 1 ) page: 893-898   1994

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  234. Identification, characterization, and developmental Expression of a novel α2→8-KDN-transferase which terminates elongation of α2→8-linked oligo-polgsialic acid chain synthesis in trout egg polysialoglycoproteins (共著)

    Glycoconjugate Journal   Vol. 11   page: 493-499   1994

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  235. Does an animal peptide : N-glycanase have the dual role as an enzyme and a carbohydrate-binding protein ? (共著)

    Glycoconjugate Journal   Vol. 11   page: 469-476   1994

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  236. Purification and enzymatic properties of peptide : N-glycanase from C3H mouse-derived L-929 fibroblast cells. (共著)

    The Journal of Biological Chemistry   Vol. 269 ( 26 ) page: 17611-17618   1994

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  237. Isolation, structural determination, and calcium-binding properties of the major glycoprotein present in Bufo Japouicus japonicus egg jelly (共著)

    European Journal of Biochemistry   Vol. 223   page: 223-231   1994

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  238. Identification of polysialic acids in glycoconjugates (共著)

    Methods in Enzymology   Vol. 230   page: 460-484   1994

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  239. Identification, developmental expression and tissue distribution of deaminonouraminate hydrolase (KDNase) activity in rainbow trout (共著)

    Glycobiology   Vol. 4 ( 4 ) page: 517-523   1994

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  240. Developmental Expression of trout egg poly sialogly coproteis and the preroquisite α2,6-, and α2,8-sialyl and α2,8-poly-sialyltransferase activities required for their synthesis during oogenesis (共著)

    The Journal of Biological Chemistry   Vol. 269 ( 14 ) page: 10330-10340   1994

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  241. Structural studies of a novel type of penta artennary large glycan unit in the fertilization-associated carbohydraterich glycopeptide isolated from the fertilized eggs of Oryzias latipes (共著)

    The Journal of Biological Chemistry   Vol. 269 ( 12 ) page: 8762-8771   1994

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  242. Monoclonal antibody speatic for α2→8-linked olrgo dominated neuraminic acid (KDN) sequeuces in glycoproteins. Preparation and characterization of a manoclonal antibody and its application in immunohistochemistry (共著)

    Histochemistry   Vol. 101 ( 5 ) page: 333-340   1994

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  243. Identification of polysialic acid-containing glyroprotein in the jelly coat of sea urchin eggs. (共著)

    The Journal of Biological Chuistry   Vol. 269 ( 36 ) page: 22712-22718   1994

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  244. CMP-3-Deoxynonulosonate Synthetase which Catalyzes the Transfer of CMP to KDN from CTP : Partial Purification and Characterization of the Enzyme from Rainbow trout testis. (共著)

    Polysiolic Acid, Birkh(]J1103[)user-Verlag Basel, Switzerland     page: 191-199   1993

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  245. Structural diversity in the α2→8-linked polysiolic acid chains in Solmonid fish egg glycoproteins. (共著)

    The Journal Biological Chemistry   Vol. 268   page: 23675-23684   1993

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  246. Analytical methods for identifying and quantitating poly (α2→8 Sia) structures containing Neu5Ac, Neu5Gc, and KDN.(共著)

    Polysialic acid, Birkh〓user-Verlag, Basel, 5witzerland     page: 183-189   1993

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  247. Immunochemical Method as Early Diagnosis for Distinguishing Salmonid Fish Female and Male Prior to Genital Maturation by use of a Minute Amount of Blood Collected from a Single Piece of Gill Filament (共著)

    Nippon Suisan Gakkaishi   Vol. 59 ( 4 ) page: 593-600   1993

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  248. Monoclonal Antibody Specific to α-2→3-Linked Deaminated Neuraminyl β-Galactosyl Sequence (共著)

    Glycobiology   Vol. 3   page: 31-36   1993

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  249. Synthesis of CMP-Deaminoneuraminic Acid (CMP-KDN) Usig the CTP : CMP-3-Deoxynonulosonate Cytidylyl-transferase from rainbow trout testis. (共著)

    The Journal of Biological Chemistry   Vol. 268   page: 2640-2648   1993

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  250. Identification of peptide : N-glycanase activity in mammalian-derived cultured cells (共著)

    Biochemical and Biophysical Research Communication   Vol. 194 ( 3 ) page: 1124-1130   1993

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  251. Structure of novel gangliosides, deaminated neurominic acid (KDN)-containing glycosphingolipids, isolated from rainbow trout ovarian fluid (共著)

    Biochemistry   ( 32 ) page: 9221-9229   1993

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  252. Structure studies of a novel type of tetraantennary sialoglycan unit in a carbohydrate-rich glycopeptide isolated from the fertilized eggs of Indian medaka fish, Oryzias melastigma (共著)

    The Journal of Biological Chemistry   Vol. 268   page: 2353-2362   1993

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  253. Analytical Methods for Identifying and Quantitating Deamidated Sialic Acid and α2→8-Linked Poly(Oligo)nonulosonate Residues in Glycoconjugates

    Analytical Biochemistry   Vol. 205   page: 244-250   1992

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  254. KDN : A novel scelit acid analogue

    Protein, nucleic acid and enzyme   Vol. 37 ( 11 ) page: 1976-1981   1992

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  255. Detection, isolation, and characterization of oligo/poly(sialic acid) and oligo/poly (deamino-niuraminic acid) units in glycoconjugates (共著)

    Analytical Biochemistry   Vol. 202   page: 25-34   1992

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  256. Fish egg glycophosphoproteins have species-specific N-linked glycan units previously found in a storage pool of free glycan chains (共著)

    The Journal of Biological Chemistry   Vol. 267 ( 34 ) page: 24287-24296   1992

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  257. Peptide : N-glycanase activity found in the early embryos of Oryzias latipes (Medaka fish) (共著)

    The Journal of Biological Chemistry   Vol. 266 ( 33 ) page: 22110-22114   1991

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  258. Isolation and structural elucidation of a novel type of ganglioside, deaminated neuraminic acid (KDN)-containing glycosphingolipid, from rainbow trout sperm. The first example of the natural occurrence of KDN-ganglioside, (KDN)GM3.(共著)

    The Journal of Biological Chemistry   Vol. 266 ( 22 ) page: 21929-21935   1991

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  259. Identification of rainbow traet of delayed maturity(3-yera-maturation) based on cortical alveolar glycopooteins (hyosophorin).

    Nippon Suisan Gakkaishi   Vol. 57 ( 7 ) page: 1355-1364   1991

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  260. Identification of free glycan chain liberated by de-N-glycosylation of the cortical alveolar glycoprotein (hyosophorin) during early embryogenesis of the medaka fish, Oryzias latipes.(共著)

    Biochemical and Biophysical Research Communication   Vol. 180 ( 3 ) page: 1165-1171   1991

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  261. Structure and Biological Function of Cortical Alveolus Glycoprotein(hyosophorin)

      Vol. 7 ( 3 ) page: 125-132   1990

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  262. Deaminated neuraminic acid-rich glycoprotein of rainbow trout egg vitelline envelope. Occurrence of a novel α-2,8-linked oligo(deaminated neuraminic acid) structure in O-linked glycan chains.(共著)

    The Journal of Biological chemistry   Vol. 265 ( 35 ) page: 21811-21819   1990

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  263. New tandem-repeating peptide structures in pulysialo-ghycoproteins from the unfertilized eggs of kokanee salmon.(共著)

    Archives of Biochemistry and Biophysics   Vol. 283 ( 1 ) page: 167-172   1990

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  264. Isolation and structures of glycoprotein-derived free sialooligosaccharide from the unfertilized eggs of Tribolodon hakonensis, a dace. Intracellular accumulation of a novel class of biantennary disialooligosaccharides.(共著)

    The Journal of Biological Chemistry   Vol. 264   page: 18520-18526   1989

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  265. Isolation and characterization of cleaminated neuraminic acid-rich glycoprotein (KDN-gp-OF) in the ovarian fluid of rainbow trout.(共著)

    Biochemical and Birophysical Research Communication   Vol. 164   page: 1744-1749   1989

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  266. Mitogenic activity of pine cone extracts against cultured splenocyta from normal and tumor-bearing animals.(共著)

    Anticancer Research   Vol. 9   page: 961-966   1989

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  267. Isolation and Characterization of a Novel Type of Sialoglycoproteins(Hyosophorin)from the Egg of Medaka, Oryzias latipes : Nonapeptide with a Large N-Linked Glycan Chainasa Tandem Repeat Unit

    Developmental Biology   Vol. 132   page: 544-553   1989

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  268. Inhibition of herpes simplex virus infection by tannins and related compounds.(共著)

    Antiviral Research   Vol. 11   page: 285-298   1989

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  269. Structural Studies of Fertilization-associated Carbohydrate-rich Glycoproteins(Hyosophorin) Isolated from the Fertilized and Unfertilized Eggs of Flounder, Parolichthys olivaceus.

    The Journal of Biological Chemistry   Vol. 264 ( 27 ) page: 15922-15929   1989

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  270. Molecular Cloning and Characterization of cDNAs Coding for Apo-Polysialoglycoprotein of Rainbow trout Eggs.

    The Journal of Biological Chemistry   Vol. 263 ( 33 ) page: 17678-17684   1988

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  271. A Proteinase Associated with Cortices of Rainbow Trout Eggs and Involved in Fertilization-Induced Depolymerlzation of Polysialoglycoproteins

    Developmental Biology   Vol. 129   page: 270-274   1988

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  272. comparative Structures of the Apopolysialoglycoproteins from Unfertilized and Fertilized Eggs of Salmonid Fishes

    Biochemistry   Vol. 27   page: 7141-7145   1988

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  273. Use of a Bacteriophage-derived Endo-N-acetylneuraminidase and an Equine Antipolysialyl Antibody to characterize the Polysialyl Residues in Salmonid Fish Egg Polysialoglycoproteins.

    The Journal of Biological Chemistry   Vol. 263 ( 34 ) page: 18269-18276   1988

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  274. KDN-glycoprotein: A novel deaminated neuraminic acid-rich glycoprotein isolated from vitelline envelope of rainbow trout eggs.(共著)

    Biochemical and Biophysical Research Communication   Vol. 153   page: 172-176   1988

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  275. Localization of polysialoglycoprotein as a major glycoprotein component in cortical alveoli of the unfertilized eggs of Salmo gairclneri.(共著)

    Developmental Biology   Vol. 123   page: 442-454   1987

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  276. A naturally occurring deaminated neuraminic aced, 3-deoxy-D-glycero-D-galacto-nonulosonic acid (KDN). Its unique occurrence of the nonredueing encls of oligosialyl chains in polysialoglycoprotein of rainbow trout eggs.(共著)

    The Journal of Biological chemistry   Vol. 261   page: 11550-11557   1986

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  277. Polysialoglycoproteins of Salmonidae Fish Eggs. Complete structure of 200-kDa polysialoglycoprotein from the unfertilizaed eggs of rainbow trout.

    The Journal of Biological Chemistry   Vol. 261 ( 12 ) page: 5262-5269   1986

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  278. A mechanistic consideration of the hydrazinolysis of 3-O-substituted, 2-acetgmido-2-deoxy-D-hexopyranosyl and-D-hexitol residues in the absence and presence of hydroziniun sulfate.(共著)

    Carbhyolrate Research   Vol. 135   page: 342-347   1985

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  279. Fish Egg Polysialoglycoproteins : Circular Dichroism and Proton Nuclear Magnetic Resonance Studies of Novel Oligosaccharide Units Containing One Sialidase-Resistant N-Glycolylneuraminic Acid Residuein Each Molecule

    Biochemistry   Vol. 23   page: 305-309   1984

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  280. Novel oligosaccharide chains on polysialog lycoproteins isolated from rainbow trout eggs.(共著)

    Biochemistry   Vol. 23   page: 305-310   1984

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  281. Isolation and structures of the third mceJor type of carbohydrate units in polysialoglycoproteins from rainbow trout eggs.(共著)

    Biochemistry International   Vol. 8   page: 573-579   1984

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    Language:English  

▼display all

Books 33

  1. Biological roles of glycan chains Reviewed

    ( Role: Joint editor)

    2020.2  ( ISBN:978-4-8158-0981-2

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    Total pages:306   Responsible for pages:306   Language:Japanese Book type:Textbook, survey, introduction

  2. Glycome: The Hidden Code in Biology Reviewed

    Chihiro Sato, Ken Kitajima( Role: Contributor ,  Chapter 5. Polysialic Acid as an Integrative Decoder in Nervous and Reproductive Systems)

    nova science publisher  2021.5  ( ISBN:978-1-53619-377-0

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    Language:English Book type:Scholarly book

  3. Role of polysialic acid in schizophrenia Reviewed

    Sato C., Hane M, Kitajima, K( Role: Joint author)

    Elsevier  2020 

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    Language:English Book type:Scholarly book

    DOI: doi.org/10.1016/B978-0-12-819475-1.00026-2 1

  4. 未来を創るグライコサイエンス:我が国のロードマップ Reviewed

    北島健( Role: Joint author ,  3-44 遺伝子改変:小型魚類 (3))

    日本糖鎖科学コンソーシアム、エム ディー オー  2018 

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    Total pages:333   Responsible for pages:227-229   Language:Japanese Book type:General book, introductory book for general audience

  5. Hsp70の酸性複合糖質結合活性の発見. 糖の意外な働き

    原田陽一郎、佐藤ちひろ、北島健( Role: Joint author)

    国際文献社  2017 

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    Language:Japanese

  6. 第2章糖鎖と生命 第1節 受精

    北島健( Role: Sole author)

    エヌ・ティー・エス  2015 

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    Language:Japanese

  7. Polysialic acid

    Chihiro Sato, Ken Kitajima ( Role: Joint author)

    Springer  2015 

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    Language:English

  8. Polysialyltransferase assay

    Masaya Hane, Ken Kitajima, Chihiro Sato( Role: Joint author)

    Springer  2015 

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    Language:English

  9. Flagellasialin: A highly glycosylated GPI-anchored protein involved in intracellular Ca2+ regulation in sea urchin sperm.

    Kanazawa T**, Suzuki E*, Miyata S, Sato C, and Kitajima K.( Role: Joint author)

    Springer  2015 

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    Language:English

  10. Enzyme assay of polysialyltransferase

    Kitajima K, Sato C. ( Role: Joint author)

    JCGGDB  2014 

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    Language:English

  11. Advanced technologies in sialic acid and sialoglycoconjugate analysis

    Ken Kitajima, Nissi Varki, and Chihiro Sato.( Role: Joint author)

    Springer  2013 

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    Language:English

  12. N-acetylneuraminic acid 9-phosphatase (NANP)

    Ken Kitajima( Role: Sole author)

    Springer  2013 

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    Total pages:5   Language:English

  13. Biological problems, methods, and applications (The roles of carbohydrate binding in cell adhesion and inflammation.)

    Kitajima, K. and Sato, C.( Role: Joint author)

    John Wiley and Sons  2011 

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    Language:English

  14. Analysis of glycan-protein interaction by frontal affinity chromatofraphy and Biacore in Methods in Enzymology (Minoru Fukuda ed. in glycomics)

    Sato C., Kitajima, K. and Sato, C.( Role: Joint author)

    Elsevir science  2010 

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    Language:English

  15. 生物学辞典

    北島健( Role: Joint author)

    東京化学同人  2010 

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    Language:Japanese

  16. 18. Enzyme assay of polysialyltransferase. in Glycoscience Protocol Online

    Ken KItajima( Role: Joint author)

    JCGG-DG  2010 

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    Language:English

  17. Glycoscience Lab Manual (Membrane microdomain as a platform of carbohydrate-mediated interaction during early development of medaka fish.)

    Adachi, T., Sato, C., and Kitajima, K.( Role: Joint author)

    Springer  2008 

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    Language:English

  18. Glycoscience Lab Manual (Structural analysis of polysialic acid)

    Sato, C., and Kitajima, K.( Role: Joint author)

    Springer  2008 

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    Language:English

  19. 実験医学・受精における糖鎖の役割

    北島健( Role: Sole author)

    羊土社  2007 

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    Language:Japanese

  20. 細胞工学・シアル酸の構造多様性とその生物学的意義

    北島健、郷慎司、藤田明子、佐藤ちひろ( Role: Joint author)

    秀潤社  2007 

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    Language:Japanese

  21. 新編精子学・精子表面の糖脂質の役割

    北島健( Role: Sole author)

    東京大学出版会  2006 

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    Language:Japanese

  22. 未来を拓く糖鎖科学・ポリシアル酸の構造解析

    北島健( Role: Joint author)

    金芳堂  2005 

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    Language:Japanese

  23. 遺伝子医学MOOK 3 糖鎖と病気・4)ポリシアル酸. 5糖鎖と発生

    佐藤ちひろ、北島健( Role: Joint author)

    メディカルドゥ  2005 

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    Language:Japanese

  24. 未来を拓く糖鎖科学・メダカ初期胚における糖鎖に富む生体膜マイクロドメインの役割

    北島健( Role: Sole author)

    金芳堂  2005 

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    Language:Japanese

  25. 生化学実験講座

    北島健( 編:日本生化学会編)( Role: Joint author)

    東京化学同人  2000 

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    Language:Japanese

    16・11KDN: デアミノノイラミン酸

  26. KDN:デアミノノイラミン酸

    日本生化学会編 基礎生化学実験法、東京化学同人  2000 

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    Language:Japanese

  27. Occurrence of alpha-2,8-linked oligosialic acid residues in mammalian glycoproteins.

    Sialobiology and Other novel Form of Glycosylation, a monograph (Inoue, Y., Lee, Y. C., and Troy, F. A., eds) Gakushin Syuppan, Osaka, Japan  1999 

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    Language:English

  28. 細胞機能と代謝マップ

    "安形高志,北島健,井上康男( 編:日本生化学会)"( Role: Joint author)

    東京化学同人  1997 

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    Language:Japanese

    7.4.3.KDN(デアミノノイラミン酸)

  29. 生体物質の化学(共著)

    大日本図書  1996 

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    Language:Japanese

  30. 新化学ライブラリー

    北島健、井上康男( 編:日本化学会)( Role: Joint author)

    大日本図書  1996 

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    Language:Japanese

    生体物質の化学

  31. KDN-ganglioside

    Guide to techniques in Ganglioside Research  1995 

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    Language:English

  32. 生物化学実験法シリーズ:ガングリオシド研究法

    "北島健,井上貞子( 編:鈴木康夫,安藤進)"( Role: Joint author)

    学会出版センター  1995 

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    Language:Japanese

    KDN-ガングリオシド

  33. ポリシアル酸 (共著)

    講談社グリコバイオロジーシリーズ  1993 

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    Language:Japanese

▼display all

Presentations 129

  1. Sulfation of sialic acid is ubiquitous and essential for vertebrate development. Invited International conference

    Ken Kitajima

    International Conference of Sialoglycosciences (Sialoglyco 2022)  2022.9.5  International Committee of Sialoglycoscience

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    Event date: 2022.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Nagoya   Country:Japan  

  2. 2,6-Sialylation essential for normal heart development in medaka can be replaced by α2,3-sialylation. Invited International conference

    Ken Kitajima

    Canadian Glycomics Symposium  2023.5.11  Canadian Society of Glycomics

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    Event date: 2023.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Edmmonton   Country:Canada  

  3. Discovery, biosynthesis, and functions of sialic acid-specific sulfotransferases Invited International conference

    Ken Kitajima

    Gordon Research Conference on Glycobiology   2023.3.14  Gordon Research Conference

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    Event date: 2023.3

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Ventura   Country:United States  

  4. 小型魚類の全組織グライコミクスの現状と展望 Invited

    北島健, 呉迪, 大本敬之, 羽根正弥, 佐藤ちひろ, 山川奈緒, Guerardel Yann.

    第93回日本生化学会大会シンポジウム1S01e「多領域に拡がる糖鎖の網羅的生物機能研究の最前線」  2021.11.3  日本生化学会

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:WEB   Country:Japan  

  5. 糖鎖の流儀:不均一性と場の形成 Invited

    北島健

    第17回 糖鎖科学コンソーシアムシンポジウム  2019.10.29  日本糖鎖科学コンソーシアム

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    Event date: 2019.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:株)島津製作所本社ホール, 京都  

  6. Comparative studies of the insect and vertebrate sialate 9-phosphate synthase (SPS) Invited International conference

    Ken Kitajima

    Sialoglyco 2018  Sialoglyco Organizing Committee

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    Event date: 2018.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Banff   Country:Canada  

  7. 巨大糖脂質:糖鎖に富むGPI-アンカーペプチドの進化と生理機能

    北島 健

    第7回「ナノカーボンバイオセンサーの医療応用研究会」 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:東北医科薬科大学   Country:Japan  

  8. Elusive Localization of the Insect CMP-sialic Acid Synthetases Invited International conference

    Ken Kitajima

    Glycoscience Japan- The Netherlands Joint Seminar 2016 

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    Event date: 2016.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Santa Barbara, USA   Country:United States  

  9. Why does sialic acid deficiency cause the embryonic lethality in medaka fish, Oryzias latipes? Invited International conference

    Ken Kitajima

    Glycoscience Japan- The Netherlands Joint Seminar 2016 

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    Event date: 2016.4

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Leiden, The Netherlands   Country:Netherlands  

  10. Glycan-mediated Interactions on Pig Sperm Lipid Rafts during Fertilization. Invited International conference

    Ken Kitajima

    Proceedings of the APMC11 / MST33 / AAT39 Conference 

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    Event date: 2016.3

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Phuket, Thailand   Country:Thailand  

  11. 曖昧な生体分子:糖鎖の生体機能を探る

    北島 健

    第7回「ナノカーボンバイオセンサーの医療応用研究会」 

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    Event date: 2015.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:科学技術交流財団研究交流センター   Country:Japan  

  12. 精子膜マイクロドメイン局在糖鎖の受精における役割

    北島健

    第13回日本糖鎖科学コンソーシアムシンポジウム 

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    Event date: 2015.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:愛知県産業労働センター「ウインクあいち」小ホール   Country:Japan  

  13. Functional significance of glycan-mediated interactions on sperm microdomains during fertilization International conference

    Ken Kitajima

    23rd International Symposium on Glycoconjugates (Glyco23) 

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    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (keynote)  

    Venue:Hetel Le Méridien Lav, Split, Croatia   Country:Croatia  

  14. Effects of psychiatric disorders-related intronic single nucleotide polymorphisms (iSNPs) of the polysialyltransferase ST8SIA2/STX gene. International conference

    Masaya Hane, Ken Kitajima, Chihiro Sato

    23rd International Symposium on Glycoconjugates (Glyco23) 

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    Event date: 2015.9

    Language:English   Presentation type:Poster presentation  

    Venue:Hetel Le Méridien Lav, Split, Croatia   Country:Croatia  

  15. Analysis of a ligand-binding mechanism among sialic-acid binding sites in Siglec-7. International conference

    Di Wu, Akiko Fujita, Yuko Yasukawa, Yoshihito Taniguchi, Yasuhiro Kamei, Chihiro Sato, Ken Kitajima.

    23rd International Symposium on Glycoconjugates (Glyco23) 

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    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (keynote)  

    Venue:Hetel Le Méridien Lav, Split, Croatia   Country:Croatia  

  16. Catabolism of sialic acid residues during pre-hatching development. International conference

    Bo Fu, Di Wu, Chihiro Sato, Ken Kitajima

    23rd International Symposium on Glycoconjugates (Glyco23) 

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    Event date: 2015.9

    Language:English   Presentation type:Poster presentation  

    Venue:Hetel Le Méridien Lav, Split, Croatia   Country:Croatia  

  17. Comparative characterization of the insect CMP-sialic acid synthetases in the enzyme activity and intracellular localization.

    Di Wu, Akiko Fujita, Anne Harduin-Lepers, Philippe Delannoy, Vladislav M. Panin, Chihiro Sato, and Ken Kitajima.

    4th Austria/Japan seminar on comparative and developmental glycobiology 

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    Event date: 2015.9

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Hetel Le Méridien Lav, Split, Croatia   Country:Croatia  

  18. Mining of marine invertebrate glycoconjugates with anti-microbial activity. Invited International conference

    Ken Kitajima, Yann Guérardel

    Bio-Asia 2015 Annual Conference 

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    Event date: 2015.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Matrix@Biopolis, Singapore   Country:Singapore  

  19. A polysialyltransferase SNP in a schizophrenic patient brings about the production of polysialic acids showing impaired binding and signaling of BDNF and FGF2. International conference

    8th International Symposium on Glycosyltransferases 

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    Event date: 2012.6

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Christian Abrecht University   Country:Germany  

  20. New features on biosynthesis and degradation of free sialic acids. International conference

    Kiel University Department of Chamistry Seminar 

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    Event date: 2012.6

    Language:English   Presentation type:Oral presentation (invited, special)  

    Venue:Christian Abrecht University   Country:Germany  

  21. Sia usage: How does the cell express particular sialic acid species? International conference

    Sialoglyco 2010, August, 21-26, 2010; Potsdam, Germany 

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    Event date: 2010.8

    Language:English   Presentation type:Oral presentation (invited, special)  

  22. Discovery of a 16-30-kDa, highly glycosylated glycoprotein from pig seminal plasma (WGA16) that regulates sperm fertilizability. International conference

    25th International Carbohydrate Symposium (ICS2010) Makuhari Messe International Convention Complex; Tokyo(Chiba), Japan 

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    Event date: 2010.8

    Language:English   Presentation type:Oral presentation (invited, special)  

  23. ラット海馬におけるシアル酸分子種含有糖鎖の発現.

    日本薬学会第130年会 

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    Event date: 2010.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  24. 細胞外シアル酸およびその前駆体のシアル酸生合成への効果

    日本農芸化学会2010年度大会. 

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    Event date: 2010.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  25. CMP-シアル酸合成酵素のCMP-KDN合成能の構造的基盤.

    日本農芸化学会2010年度大会. 

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    Event date: 2010.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  26. グリコサミノグリカン鎖と脳由来神経栄養因子の相互作用の解析.

    日本農芸化学会2010年度大会. 

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    Event date: 2010.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  27. ブタ精子細胞膜マイクロドメイン局在糖タンパク質の受精における機能

    日本農芸化学会2010年度大会. 

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    Event date: 2010.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  28. シグレック-7のオリゴシアル酸結合能および新規シアル酸結合ドメインの存在証明.

    CREST糖鎖最終シンポジウム. 

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    Event date: 2010.1

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  29. ポリシアル酸と統合失調症.

    第7回糖鎖科学コンソーシアムシンポジウム-糖鎖研究と他領域との統合[グライコケミカルバイオロジーとグライコテクノロジーへの展開] 

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    Event date: 2009.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  30. Molecular mechanism for differential recognition of the C-5 substituents of sialic acid by CMP-sialic acid synthetases: Identification of the evolutionally conserved sialic acid recognition region. International conference

    20th International Symposium on Glycoconjugate (GlycoXX 2009); Nov 29-Dec 4, 2009; San Juan, Puerto Rico 

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    Event date: 2009.11

    Language:English   Presentation type:Poster presentation  

  31. A new function of polysialic acid on NCAM as the reservoir for the particular groups of neurotrophins, growth factors, and neurotransmitters that regulate the neural activity. International conference

    20th International Symposium on Glycoconjugate (GlycoXX 2009); Nov 29-Dec 4, 2009; San Juan, Puerto Rico 

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    Event date: 2009.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  32. In silico and in vitro binding studies predict a novel sialic acid binding site on the sialic acid binding Ig-like lectin-7 (Siglec-7). International conference

    20th International Symposium on Glycoconjugate (GlycoXX 2009); Nov 29-Dec 4, 2009; San Juan, Puerto Rico 

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    Event date: 2009.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  33. Membrane Microdomains as a Platform of Carbohydrate-mediated Cell-cell Interactions during Gastrulation. International conference

    4th 2009 Annual Meeting of Koren Society of Glycoscience, 2009 KSG International Glycoscience Symposium; Dajeon, Korea 

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    Event date: 2009.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  34. シアル酸結合免疫グロブリン様レクチン(シグレック)-7によるシアロ糖鎖認識の生化学的および分子ドッキング解析.

    第47回日本生物物理学会年会. 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  35. 魚類CMP-シアル酸合成酵素の構造とシアル酸分子種認識.

    第82回日本生化学会大会. 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  36. CMP-シアル酸合成酵素のシアル酸分子種認識および核局在決定領域の生物種間比較.

    第82回日本生化学会大会. 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  37. ポリシアル酸転移酵素の一塩基多型変異体の酵素活性と統合失調症との関連.

    第82回日本生化学会大会. 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  38. 分子ドッキングおよび生化学的結合解析によるシグレック-7の糖鎖認識の構造学的知見.

    第82回日本生化学会大会. 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  39. マウス新生仔脳局在A2B5エピトープ含有糖タンパク質のシアロ糖鎖の特徴と生合成

    第82回日本生化学会大会. 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  40. NCAMを修飾するポリシアル酸鎖とFGF-2の相互作用解析.

    第82回日本生化学会大会. 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  41. Siglec-7のオリゴシアル酸結合能の解析と新規シアル酸結合ドメインの存在検証.

    第82回日本生化学会大会. 

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    Event date: 2009.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  42. マウス脳発達段階におけるA2B5エピトープ含有糖タンパク質の発現と解析.

    糖鎖科学名古屋拠点[若手の力]フォーラム第7回. 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  43. ブタ精子膜マイクロドメインに局在する糖タンパク質の役割解明.

    糖鎖科学名古屋拠点[若手の力]フォーラム第7回. 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  44. メダカ初期胚生体膜マイクロドメインに局在する巨大糖タンパク質の発現解析と精製・性質.

    糖鎖科学名古屋拠点[若手の力]フォーラム第7回. 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  45. ウニの受精・発生過程における2E8糖鎖エピトープの発現と機能解析.

    糖鎖科学名古屋拠点[若手の力]フォーラム第7回. 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  46. メダカ初期胚生体膜マイクロドメイン局在メガ糖タンパク質の発現解析と精製.

    日本動物学会第80回大会. 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  47. ウニの受精および初期発生における2E8糖鎖抗原の発現変化.

    日本動物学会第80回大会. 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  48. ブタ精子細胞膜マイクロドメイン局在糖タンパク質の同定と受精能獲得における変化.

    日本動物学会第80回大会. 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  49. 分子ドッキングおよび生化学的結合解析によるシグレック-7の糖鎖認識の構造学的知見.

    第29回日本糖質学会年会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  50. 魚類CMP-シアル酸合成酵素の構造とシアル酸分子種認識.

    第29回日本糖質学会年会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  51. Glycosaminoglycan-dependent complex formation of 70-kDa heat shock protein.

    第29回日本糖質学会年会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  52. ブタ精子マイクロドメインに局在し多分散性を示す糖タンパク質の同定.

    第29回日本糖質学会年会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  53. マウス脳発達段階特異的に発現するA2B5エピトープ含有糖タンパク質の糖鎖解析.

    第29回日本糖質学会年会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  54. ウニの受精・発生過程における2E8糖鎖エピトープの発現と機能解析

    第29回日本糖質学会年会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  55. NCAMを修飾するポリシアル酸鎖とFGF-2の相互作用解析.

    第29回日本糖質学会年会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  56. メダカ初期胚生体膜マイクロドメインに局在する巨大糖タンパク質の発現解析と精製

    第29回日本糖質学会年会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  57. Siglec-7のオリゴシアル酸結合能の解析と新規シアル酸結合ドメインの存在検証.

    第29回日本糖質学会年会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  58. CMP-シアル酸合成酵素の基質認識および細胞内局在決定領域の生物種間比較.

    第29回日本糖質学会年会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  59. 統合失調症に関わるポリシアル酸転移酵素変異体の活性解析.

    第29回日本糖質学会年会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  60. CMP-シアル酸合成酵素の進化とシアル酸認識機構の相関.

    FCCAグライコサイエンス若手フォーラム. 

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    Event date: 2009.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  61. ポリシアル酸と線維芽細胞増殖因子との相互作用解析.

    FCCAグライコサイエンス若手フォーラム. 

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    Event date: 2009.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  62. 分子モデリング法による熱ショックタンパク質(Hsp70)の酸性糖脂質結合性の解析.

    名古屋大学若手女性研究者サイエンスフォーラム. 

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    Event date: 2009.8

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  63. オリゴシアル酸とSiglec-7との相互作用解析.

    第73回日本生化学会中部支部例会. 

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    Event date: 2009.5

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  64. Novel aspects of substrate specificity and nuclear localization of CMP-sialic acid synthetases as revealed by studies of fish enzymes.

    ORI Seminar; April 27, 2009; Ocean Research Institute, University of Tokyo, Tokyo 

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    Event date: 2009.4

    Language:English   Presentation type:Oral presentation (invited, special)  

  65. Polysialic acid is not a negative regulator any longer in neurogenesis and neuronal functions: A new finding of its binding to a particular group of neurotransmitters. International conference

    Gordon Research Conference on Glycobiology 

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    Event date: 2009.3

    Language:English   Presentation type:Poster presentation  

  66. Membrane microdomains as a plarform of carbohydrate- and protein-mediated cell-cell interaction in fertilization and early development International conference

    Biochemistry and Molecular Biology 

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    Event date: 2008.12

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  67. A one-day symposium on Sialyltransferases, Functional Glycomics, and Genomics of Zebrafish International conference

    Functional Glycomics, and Genomics of Zebrafish 

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    Event date: 2008.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  68. Membrane microdomains from early gastrula embryos of medaka are a platform of E-cadherin- and LeX-mediated cell-cell interactions during epiboly International conference

    14th Japanese Medaka and Zebrafish Meeting 

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    Event date: 2008.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  69. Occurrence of the Cyclic Sialic Acid in Mammalian Cells and Tissues As Demonstrated by Chemical Methods.

    24th International Carbohydrate Symposium 

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    Event date: 2008.7

    Language:English   Presentation type:Oral presentation (invited, special)  

  70. Significance of the existence of deaminoneuraminic acid (KDN) in mammalian cells in Its metabolic and functional features. International conference

    SialoGlyco Conference 2008 

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    Event date: 2008.7

    Language:English   Presentation type:Oral presentation (invited, special)  

  71. シアロメタボロームから見た生命科学シンポジウム「次世代の糖鎖科学」

    北島 健

    日本農芸化学会2008年度大会 

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    Event date: 2008.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  72. ウニ精子表面シアロ糖鎖の受精における役割

    北島健

    日本動物学会第78回大会 シンポジウム「受精シンポジウム:温故知新による受精研究ネクストステージの幕開け-2部-」(2007年9月20-23日; 弘前大学, 弘前) 

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    Event date: 2007.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  73. Discovery of Polysialic Acid in Microglia. Expression Changes of α2,8-Sialyltransferases During Activation of a Mouse Microglia Cell Line International conference

    19th International Symposium on Glycoconjugates (July 15-20, 2007; Cairns, Australia) 

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    Event date: 2007.7

    Language:English   Presentation type:Oral presentation (invited, special)  

  74. Polysialic acids on O-glycans: Their occurrence, structural diversity, and biosynthesis International conference

    Polysialic acid: Chemistry, Biology, Translational Aspects, 3rd International Meeting (Bad Lauterberg, Germany) 

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    Event date: 2007.3

    Language:English   Presentation type:Oral presentation (invited, special)  

  75. A short-term regulation of polysialic acid expression in microglia International conference

    Gordon Research Conference on Glycobiology (Ventura, U.S.A.) 

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    Event date: 2007.3

    Language:English   Presentation type:Oral presentation (invited, special)  

  76. ポリシアル酸:普遍的存在、構造多様性および機能

    北島健

    第4回糖鎖科学コンソーシアムシンポジウム~糖鎖機能の解明からシステム糖鎖生物学への統合へ向けて~ (2006年10月23-24日;東京) 

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    Event date: 2006.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  77. Discovery of Polysialic Acid in Microglia. Expression Changes of α2,8-Sialyltransferases During Activation of a Mouse Microglia Cell Line International conference

    5th International Symposium on Glycosyltransferases (June 25-28, 2006; Tsukuba, Japan) 

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    Event date: 2006.6

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  78. Development of a chemical method for detecting a unique sialic acid, cyclic neuraminic acid, in naturally-occurring sialyl glycoconjugates International conference

    Pacifichem 2005 (2005.12; Hawaii, USA) 

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    Event date: 2005.12

    Language:English   Presentation type:Oral presentation (invited, special)  

  79. Significance of membrane microdomains in the carbohydrate-dependent cell-cell interactions during early development of medaka fish International conference

    2nd Japan-The Netherlands Glycobiology Symposium (April 18-20, 2005; Utrecht, The Netherlands) 

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    Event date: 2005.4

    Language:English   Presentation type:Oral presentation (invited, special)  

  80. An essential role of carbohydrate-enriched membrane microdomains (rafts) in gastrulation of medaka fish, Oryzias latipes International conference

    Gordon Research Conference on Glycobiology (Ventura, U.S.A.) 

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    Event date: 2005.3

    Language:English   Presentation type:Poster presentation  

  81. ポリシアル酸の鎖長多様性と神経系における新機能

    北島健

    第23回シアル酸研究会講演会「シアル酸と記憶」(2005年12月; 東京) 

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    Event date: 2004.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  82. A carbohydrate-mediated binding of sperm gangliosides with the sperm binding protein in vitelline layer as a molecular base for the sea urchin sperm-egg interaction International conference

    4th International Symposium on the Molecular and Cell Biology of Egg- and Embryo-Coats (MCBEEC2004) (2004.11; Ise, Japan) 

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    Event date: 2004.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  83. Polysialic acid in mammary gland International conference

    4th International Symposium on Glycosyltransferases GlycoT2004. (2004.11; Le Touquet, France) 

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    Event date: 2004.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  84. 生体膜マイクロドメインを通して糖鎖認識分子群を探究する

    北島健

    第53回高分子討論会「ここまできた糖鎖工学と化学生物学の展開」(2004.9.; 札幌) 

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    Event date: 2004.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  85. Linkage and chain length diversities of the polysialic acid in animal glycoproteins International conference

    Sialobiology 2004. 4th International Conference. (2004.7; St Andrews, UK) 

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    Event date: 2004.7

    Language:English   Presentation type:Oral presentation (invited, special)  

  86. 糖脂質マイクロドメイン:細胞間相互作用を媒介する分子集合体

    北島健

    日本農芸化学会中部支部第140回例会. シンポジウム「ポスト・ポストゲノム:糖と脂質の最前線」(岐阜) 

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    Event date: 2004.6

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  87. Identification and characterization of a new heat shock protein-like lectin on the egg surface of sea urchin International conference

    21st International Lectin Meeting (2004.5; Shonan, Japan) 

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    Event date: 2004.5

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  88. Identification of glycosylated alpha-lactoalbumin as endogenous substrate for beta-1,4-galactosyltransferase (GalT) in colostrum International conference

    XVIth International Symposium on Glycoconjugates 

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    Event date: 2001.8

    Language:English   Presentation type:Poster presentation  

    Convention Center The Hague Netherlands

  89. Molecular cloning and developmental expression of two alpha-2,8-polysialyltransferases in rainbow trout ovary." International conference

    XVIth International Symposium on Glycoconjugates 

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    Event date: 2001.8

    Language:English   Presentation type:Poster presentation  

    Convention Center The Hague Netherlands

  90. Sialic acid-dependent sperm raft-egg raft interactions at fertilization. International conference

    XVIth International Symposium on Glycoconjugates (August 19-24, 2001The Hague, The Netherlands) 

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    Event date: 2001.8

    Language:English   Presentation type:Oral presentation (invited, special)  

  91. Biosynthesis of a major, carbohydrate-rich cortical galveolus glycoprotein (hyosophorin) during oogenesis of Oryzias latipes International conference

    14th International Congress of Developmental Biology 

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    Event date: 2001.7

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

    Kyoto International Conference Hall Kyoto Japan

  92. Identification of adipo Q, an adipocyte specific glycoprotein, as a new oligosialic acid-containing glycoprotein and a possible substrate for the alpha2,8-sialyltransferase III (ST8Sia III) International conference

    International Symposium on Protein Trafficking, Glycosylation, and human health 

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    Event date: 2001.5

    Language:English   Presentation type:Poster presentation  

    Interlaken Interlaken Switzerland

  93. Di/oligosialic acid in glycoproteins: Differentiation-dependent expression in an adipocyte tissue specific glycoprotein, adipo Q. International conference

    Gordon Research Conference on Glycobiology 

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    Event date: 2001.3

    Language:English   Presentation type:Poster presentation  

    Four points Sheraton Ventura Harbortown Hotel Ventura U.S.A.

  94. The chicken Zp-C gene. Gene structure, granulosa-specific expression and promoter activity International conference

    3rd International Symposium of the Molecular and Cellular Biology of the Egg and Embryo Extracellular Matrix 

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    Event date: 2000.8

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

    Lake Tahoe Lake Tahoe U.S.A.

  95. Expression and glycosylation of a major, carbohydrtate-rich, cortical alveolus glycoprotein (hyosophorin) during oogenesis of medaka fish, Oryzias latipes. International conference

    3rd International Symposium of the Molecular and Cellular Biology of the Egg and Embryo Extracellular Matrix 

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    Event date: 2000.8

    Language:English   Presentation type:Oral presentation (invited, special)  

    Lake Tahoe Hotel Lake Tahoe, California U.S.A.

  96. Expression and glycosylation of a major, carbohydrtate-rich, cortical alveolus glycoprotein (hyosophorin) during oogenesis of medaka fish, Oryzias latipes International conference

    3rd International Symposium of the Molecular and Cellular Biology of the Egg and Embryo Extracellular Matrix (August 27-September 1, Lake Tahoe, California, U.S.A.) 

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    Event date: 2000.8

    Language:English   Presentation type:Oral presentation (invited, special)  

  97. KDNの生合成に関与する酵素の同定および性質

    北島 健

    第21回日本糖質学会年会(2000年7月27-29日, 名古屋国際会議場, 名古屋) 

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    Event date: 2000.7

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  98. Di- and oligosialic acids as novel carbohydrate epitopes in leukocytes. International conference

    7th Conference on human leukocyte differentiation antigens 

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    Event date: 2000.6

    Language:English   Presentation type:Poster presentation  

    Harrogate Convention Center Harrogate U.K.

  99. Di- and oligosialic acids as novel carbohydrate epitopes in leukocytes International conference

    7th Conference on human leukocyte differentiation antigens (Harrogate, UK, June 20-24, 2000) 

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    Event date: 2000.6

    Language:English   Presentation type:Poster presentation  

  100. Cloning and characterization of N-acetylgalactosaminide (2,6-sialyltransferase (ST6GalNAc II) responsible for sialylation of rainbow trout egg polysialoglycoprotein. International conference

    2nd International Symposium on Glycosyltransferase: Glycosyltransferases in the New Millenium 

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    Event date: 2000.5

    Language:English   Presentation type:Poster presentation  

    The Hospital for Sick Children Toronto Canada

  101. Spontaneous galactosylation of agalactoglycoproteins in colostrum. A possible role of milk 1,4-galactosylatransferase. International conference

    2nd International Symposium on Glycosyltransferase: Glycosyltransferases in the New Millenium 

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    Event date: 2000.5

    Language:English   Presentation type:Poster presentation  

    The Hospital for Sick Children Toronto Canada

  102. Gametic cell rafts-mediated sperm-egg interaction at fertilization International conference

    Invited Seminar at Loeb Health Research Institute (University of Ottawa, ON, Canada, May 8, 2000) 

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    Event date: 2000.5

    Language:English   Presentation type:Oral presentation (invited, special)  

  103. Biosynthesis of deaminoneuraminic acid (KDN) in mammalian cells International conference

    2nd International Symposium on Glycosyltransferase: Glycosyltransferases in the New Millenium (May 12-14, 2000, The Hospital for Sick Children, Toronto, Canada) 

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    Event date: 2000.5

    Language:English   Presentation type:Poster presentation  

  104. 動物細胞表面のシアロ糖鎖工学:N-アセチルノイラミン酸からデアミノノイラミン酸(KDN)へのin vitro改変

    仲田大輔、松田 幹、北島 健

    日本農芸化学会2000年度大会 ( 東京, 2000年3月31日-4月2日) 

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    Event date: 2000.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

    2000年3月31日~4月2日;東京ビッグサイト, 東京

  105. シアル酸は面白い~シアロバイオサイエンスへの招待

    (財)科学技術交流財団「糖鎖材料生命工学研究会」セミナー (名古屋大学VBL; 11月24日 1999) 

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    Event date: 1999.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  106. ニジマス卵巣a2,6-シアル酸転移酵素(ST6GalNAcII)およびa2,8-ポリシアル酸転移酵素(ST8Sia)のcDNAクローニングと卵形成過程における発現

    朝比奈慎二、松野みどり、中瀬昌之、佐藤ちひろ、青木直人、松田幹、北島健

    第72回日本生化学会大会 

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    Event date: 1999.10

    Language:Japanese   Presentation type:Poster presentation  

    Country:Japan  

  107. 精子細胞膜の糖脂質ミクロドメインの受精における役割

    第72回日本生化学会大会 シンポジウム講演 (横浜, 10月6-9日 1999) 

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    Event date: 1999.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  108. A role of b-1,4-galactosyltransferase in in situ galactosylation of degalactosylated glycoproteins in colostrum. International conference

    XVth International Symposium on Glycoconjugates 

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    Event date: 1999.8

    Language:English   Presentation type:Poster presentation  

    Country:Japan  

    Hotel East 21 Tokyo Japan

  109. Glycosphingolipid-enriched microdomain on gametic cells as functional domain for sperm-egg interaction coupled with signal transduction International conference

    Special Seminar at Department of Med: Biological Chemistry, University of California, Davis, U.S.A. 

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    Event date: 1999.8

    Language:English   Presentation type:Oral presentation (invited, special)  

  110. Egg receptor for sperm binds to gangliosides in the low density detergent-insoluble membrane (LD-DIM) domain of the sperm surface. Possible involvement of the LD-DIM in sperm-egg binding coupled with signal transduction during fertilization International conference

    XVth International Symposium on Glycoconjugates (August 22-26, Hotel East 21, Tokyo, Japan 1999) 

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    Event date: 1999.8

    Language:English   Presentation type:Oral presentation (invited, special)  

  111. Glycosphingolipid-enriched microdomain on gametic cells as functional domain for sperm-egg interaction coupled with signal transduction International conference

    Gordon Research Conference on Fertilization and Activation of the Development (July 25-30, Holderness School, Plymouth, New Hampshire, U.S.A. 1999) 

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    Event date: 1999.7

    Language:English   Presentation type:Poster presentation  

  112. 新規なシアル酸含有糖タンパク質の生理活性

    連続公開セミナー「糖鎖の新しい生理活性」第5回セミナー (京都大学農学部, 12月12日 1998) 

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    Event date: 1998.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  113. Occurrence of oligosialic acid residues in vertebrate glycoproteins International conference

    International Symposium on Sialobiology and Other Novel Forms of Glycosylation (Taipei, Taiwan, November 9-13, 1998) 

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    Event date: 1998.11

    Language:English   Presentation type:Oral presentation (invited, special)  

  114. オリゴシアル酸含有糖タンパク質の新しい化学的および免疫化学的解析法の開発と哺乳動物細胞における普遍的存在の証明

    佐藤ちひろ、本田直輝、太田薫、福岡秀幸、井上貞子、松田幹、北島健

    第71回日本生化学会大会 (名古屋、10.14-10.17 1998) 

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    Event date: 1998.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  115. 動物細胞におけるデアミノノイラミン酸(KDN)の生合成経路およびKDN複合糖質の発現の調節機構の解析

    北島健、安形高志、仲田大輔、松田幹、Frederic A. Troy, II

    第71回日本生化学会大会 シンポジウム「糖鎖生物学の新たな展開と可能性:糖鎖合成・発現の調節機構」 

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    Event date: 1998.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

    名古屋国際会議場、名古屋、10月14-17日, 1998

  116. Expression of alpha2,8-linked oligosialic acid-containing glycoproteins in mammalian cells, depending on development, cell differentiation, and overexpression of polysialyltransferase genes International conference

    XIXth International Carbohydrate Symposium 

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    Event date: 1998.8

    Language:English   Presentation type:Poster presentation  

    University of California, San Diego, California, U.S.A., August 9-14, 1998

  117. 糖タンパク質における新しいシアル酸含有糖鎖構造とその機能

    北島 健

    平成10年度日本農芸化学会 シンポジウム「糖鎖の精密構造とその機能:生命現象に関わる糖鎖」(名古屋、名城大学、3月31日~4月3日 1998) 

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    Event date: 1998.3

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  118. Synthesis of neoglycoconjugates containing deaminated neuraminic acid (KDN) using rat liver α2,6-sialyltransferase. International conference

    10th Annual Meeting of Japanese Association for Animal Cell Technology 

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    Event date: 1997.11

    Language:English   Presentation type:Poster presentation  

    Nagoya Japan

  119. Structure and physiological activities of hyosophorin, a cortical alveolus glycoprotein of fish eggs International conference

    2nd International Symposium on the Molecular and Cell Biology of Egg- and Embryo-coats 

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    Event date: 1997.10

    Language:English   Presentation type:Poster presentation  

    Hokkaido University, Sapporo, Japan; Oct. 12-17, 1997

  120. Frequent occurrence of oligosialyl units in vertebrate glycoprotiens as evidenced by new chemical and immunochemical methods International conference

    XIVth International Symposium on Glycoconjugates 

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    Event date: 1997.9

    Language:English   Presentation type:Poster presentation  

    Zurich, Switzerland, Sep. 7-12, 1997

  121. Oligosialic acid-containing glycoproteins occur in vertebrates more frequently than recognized until now: their distribution, function, and biosynthesis International conference

    Gordon Research Conference on Glycobiology 

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    Event date: 1997.2

    Language:English   Presentation type:Poster presentation  

    Ventura, U.S.A., Feb. 2-7, 1997

  122. 新しい機能性糖鎖を探索する

    北島 健

    第32回糖鎖生命科学セミナー (東京工業大学、1月10日 1997) 

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    Event date: 1997.1

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  123. 新しい複合糖質の発見と研究展開

    北島 健

    講演会「糖鎖工学:多様な生命現象へのアプローチ」 

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    Event date: 1996.11

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

    日本化学会7階ホール、東京、11月1日 1996年

  124. Purification, characterization and catalytic mechanism of a novel sialidase, deaminoneuraminidase (KDNase), from Sphingobacterium multivorum International conference

    1st. Austrasia Conference on the Chemistry and Biochemistry of Sialic Acid-Recognising Proteins 

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    Event date: 1996.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Melbourne, Australia, Sep. 30, 1996

  125. Deaminoneuraminic acid (KDN)-containing glycoconjugates: Biological functions and potential usefulness in glycotechnology International conference

    First International Symposium on Glycobiology: 3rd Generation of biotechnology as a new frontier in biological science 

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    Event date: 1996.9

    Language:English   Presentation type:Oral presentation (invited, special)  

    Seoul, Korea, Sep. 12, 1996

  126. 魚卵に学ぶ. N-グリコシド型糖タンパク質の構造と機能

    北島 健

    平成7年度日本水産学会年会 ミニシンポジウム「海洋生命科学における糖鎖生物学・工学」 

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    Event date: 1995.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

    京都、9月27日 1995年

  127. A possible polysialylation signal in the core glycan chain of N-CAM International conference

    13th International Symposium on Glycoconjugates 

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    Event date: 1995.8

    Language:English   Presentation type:Poster presentation  

    Seattle, U.S.A., August 20-26, 1995

  128. Unique structures and structural chains of the cortical alveolar-derived glycopolyproteins in fish eggs upon fertilization and during early development International conference

    3rd International Marine Biotechnology Conference (Tromso, Norway, August 7-12, 1994) 

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    Event date: 1994.8

    Language:English   Presentation type:Poster presentation  

  129. Discovery, purification, and properties of KDNase devoid of sialidase activity: Is KDN a sialic acid? International conference

    17th International Carbohydrate Symposium (Ottawa, Canada, July 17-22, 1994) 

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    Event date: 1994.7

    Language:English   Presentation type:Poster presentation  

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Other research activities 5

  1. 自然科学機構基礎生物学研究所個別共同利用研究

    2020.4
    -
    2024.3

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    「モデル小型魚類利用によるシアル酸代謝とその能解明研究」(大学院生派遣)
    生物機能解析センター・光学解析室(亀井保博准教授)

  2. 基礎生物科学研究所との共同研究

    2020.4
    -
    2021.3

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    「モデル小型魚類利用によるシアル酸代謝とその機能解明研究」

  3. 東京工業大学との共同研究

    2020.4
    -
    2021.3

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    シアロ化合物の生理活性

  4. 自然科学機構基礎生物学研究所個別共同利用研究

    2019.4
    -
    2020.3

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    「モデル小型魚類利用によるシアル酸代謝とその能解明研究」(大学院生派遣):生物機能解析センター・光学解析室(亀井保博准教授)

  5. 自然科学機構基礎生物学研究所個別共同利用研究

    2018.4
    -
    2019.3

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    「モデル小型魚類利用によるシアル酸代謝とその能解明研究」(大学院生派遣):生物機能解析センター・光学解析室(亀井保博准教授)

Research Project for Joint Research, Competitive Funding, etc. 3

  1. ポリシアル酸認識機構を基盤とする精神疾患と癌の診断・治療の技術革新研究

    Grant number:19ae0101069h0004  2018.4 - 2021.3

    次世代治療・診断実現のための創薬基盤技術開発事業  糖鎖利用による革新的創薬技術開発事業

    佐藤ちひろ

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    Grant amount:\1000000

  2. 海洋脊索動物の構造と機能グライコミクス

    2009.4 - 2010.3

    科学技術振興機構 戦略的国際科学技術協力推進事業 

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    Grant type:Competitive

    科学技術振興機構 戦略的国際科学技術協力推進事業

  3. 受精および初期発生における糖鎖の役割解明とその応用に関する研究

    2004.4 - 2007.3

    ヒューマンサイエンス振興財団 創薬等ヒューマンサイエンス総合研究事業 KH21014 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 22

  1. 脊椎動物におけるシアル酸特異的硫酸転移酵素群の発見とその生物学的重要性の証明

    Grant number:22H02256  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(B)

    北島 健, 佐藤 ちひろ, 呉 迪, 羽根 正弥

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    Authorship:Principal investigator 

    Grant amount:\17940000 ( Direct Cost: \13800000 、 Indirect Cost:\4140000 )

    糖鎖付加はタンパク質および脂質に対する主要な修飾反応である。その糖鎖の最末端は通常シアル酸が占めており、細胞認識や細胞接着を媒介・制御している。しかし、そのシアル酸が更に硫酸化やアセチル化修飾されている事実は殆ど知られておらず、その修飾シアル酸の存在意義も不明である。近年、我々はシアル酸の修飾の中でも脊椎動物に普遍的に存在する硫酸化に着目して、その生合成酵素であるシアル酸硫酸転移酵素遺伝子を少なくとも2種類同定した。またそれらの遺伝子ノックアウトメダカが幼魚段階で致死となることを明らかにした。本研究は、これらの研究結果に基づいてシアル酸の硫酸化の生物学的意義の解明を目指す

  2. The sialate sulfotransferase in vertebrates: Identification and significance

    Grant number:19K05812  2019.4 - 2022.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kitajima Ken

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    Authorship:Principal investigator 

    Grant amount:\4420000 ( Direct Cost: \3400000 、 Indirect Cost:\1020000 )

    Glycosylation is a major modification of proteins and lipids. The non-reducing termini are usually occupied by sialic acid residues to play various biological roles. However, very little have been known about the fact that the sialic acid residues are further modified by sulfation and acetylation. The significance of the modified sialic acids has not yet been clarified, either. This study sought to reveal the biological significance of the modified sialic acids, focusing on the sulfation. In this study, we for the first time identified two different sialate: O-sulfonyltransferase genes, and determined the intracellular localization and substrate specificity of the enzymes. In addition, we generated the gene-knocout medaka for the two genes, respectively, and found that they are lethal in their young fry. Taken together, we could first demonstrate that the sulfation of sialic acdis is essential for the organism.

  3. 先天性糖鎖修飾不全症の創薬医療のためのモデルメダ カの樹立と統合的病態解明法の確立

    2018.4 - 2021.3

    公益財団法人小林国際奨学財団  研究助成金 

    北島健

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\3500000 ( Direct Cost: \3500000 )

  4. 糖鎖生物学

    Grant number:060503  2018.4 - 2019.3

    日本学術振興会  研究成果公開促進費(学術図書)

    北島健

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2236000

  5. 先天性糖鎖合成異常症の新しい治療薬開発の基盤確立

    Grant number:UEHARAZAIDAN-D-18-00087R1  2017.4 - 2019.3

    上原記念生命科学財団  研究助成金

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\5000000 ( Direct Cost: \4500000 、 Indirect Cost:\500000 )

  6. デアミノシアル酸とポリシアル酸の医用応用に向けた分子基盤の確立

    Grant number:芝049-No1-04-助成決定-4  2016.4 - 2018.3

    公益信託 医用薬物研究奨励富岳基金  研究助成金

    北島健

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\2000000 ( Direct Cost: \2000000 )

  7. 初期胚表面に存在する巨大糖鎖の機能とその分子機構の解明

    2010 - 2013.3

    科学研究費補助金  基盤研究(B),課題番号:22380187

    北島 健

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    Authorship:Principal investigator 

  8. T細胞と抗原提示細胞の相互作用における接着分子CADM1とCRTAMの役割

    2009.11 - 2010.3

    Grant-in-Aid for Scientific Research 

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    Authorship:Principal investigator 

  9. 細胞外熱ショックタンパク質70-酸性脂質複合体の構造と生理学的役割の解明

    2009.4 - 2010.3

    Grant-in-Aid for Scientific Research 

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    Authorship:Principal investigator 

  10. 動物精子表面糖鎖による新しい受精能制御の分子機構の解明

    2007.4 - 2010.3

    科学研究費補助金  基盤研究(B)(一般),課題番号:19380192

    北島 健

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    Authorship:Principal investigator 

  11. Roles of acidic glycoconjugates in mammalian fertilization

    2005.4 - 2007.3

    Grant-in-Aid for Scientific Research 

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    Authorship:Principal investigator 

  12. 細胞接着に関わるシアル酸の構造変化と細胞接着制御の解明

    2002.11 - 2008.3

    科学研究費補助金  科学技術振興機構

    神奈木玲児

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    Authorship:Coinvestigator(s) 

  13. 細胞表面に見出される新しい酸性糖鎖の機能に関する共同研究

    1998.1 - 1999.12

    科学研究費補助金  国際学術研究

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    Authorship:Principal investigator 

    科研費

  14. 糖タンパク質糖鎖におけるオリゴシアル酸鎖の発見とその普遍的存在分布の証明

    1998.1 - 1999.12

    科学研究費補助金  基盤研究(C)(2)

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    Authorship:Principal investigator 

    科研費

  15. 細胞間接着における糖質ー糖質間相互作用の役割と分子機構の解明

    1998.1 - 1998.12

    科学研究費補助金  特定領域研究(A)(2)

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    Authorship:Principal investigator 

    科研費

  16. 細胞表面に見出される新しい酸性糖鎖の機能に関する共同研究

    1997.1 - 1998.12

    科学研究費補助金  国際学術研究

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    Authorship:Principal investigator 

    科研費

  17. 細胞間接着における糖質ー糖質間相互作用の役割と分子機構の解明

    1997.1 - 1997.12

    科学研究費補助金  重点領域研究

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    Authorship:Principal investigator 

    科研費

  18. デアミノノイラミン酸残基特異的な新規シアリターゼ(KDNase)

    1996.1 - 1996.12

    科学研究費補助金  萌芽的研究

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    Authorship:Principal investigator 

    科研費

  19. 細胞表面に見出された新規ポリシアル酸、KDN、硫酸化糖鎖の機能に関する共同研究

    1996.1 - 1996.12

    科学研究費補助金  国際学術研究

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    Authorship:Principal investigator 

    科研費

  20. デアミノノイラミン酸(KDN)残基をもつ新しい生理活性複合糖質の開発と応用

    1995.1 - 1996.12

    科学研究費補助金  試験研究(B)

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    Authorship:Principal investigator 

    科研費

  21. デアミノノイラミン酸残基特異的な新規シアリダーゼ(KDNase)

    1995.1 - 1995.12

    科学研究費補助金  一般研究(C)

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    Authorship:Principal investigator 

    科研費

  22. 哺乳動物正常及び腫瘍細胞におけるKDN-複合糖質の分布及び機能に関する共同研究

    1995.1 - 1995.12

    科学研究費補助金  国際学術研究

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    Authorship:Principal investigator 

    科研費

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Industrial property rights 2

  1. 新規デアミノノイラミニダーゼとその製造方法

    北島健

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    Patent/Registration no:特許3647873号  Date registered:2005.2 

    Country of applicant:Domestic  

  2. 新規グリコペプチダーゼとその製造方法

    井上康男、井上貞子、北島健

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    Applicant:生化学工業株式会社

    Patent/Registration no:特許3795558号  Date registered:2006.4 

    Country of applicant:Domestic  

 

Teaching Experience (On-campus) 8

  1. Bioorganic Chemistry (G30)

    2020

  2. 修士論文研究2

    2020

  3. 修士論文研究1

    2020

  4. 生命農学演習2

    2020

  5. 生命農学演習1

    2020

  6. 糖鎖生物学特論I

    2020

  7. 農学セミナー

    2020

  8. 生物化学I

    2020

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Teaching Experience (Off-campus) 4

  1. Sialobiology: a fascinating area of study to solve the mystery of glycans

    2019.5

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    Level:Postgraduate  Country:Austria

  2. 細胞表面情報分子

    1998.4 - 1999.3 岐阜薬科大学)

  3. 応用生物科化学特論

    1998.4 - 1999.3 静岡大学 農学部)

  4. 生体高分子学

    1997.4 - 1998.3 東京大学 大学院理学系研究科)

 

Social Contribution 4

  1. 長野県飯田高等学校への出前講義

    Role(s):Appearance, Lecturer, Planner

    長野県飯田高等学校  高校1年生進路研修  2019.12

  2. 中華人民共和国深セン明徳実験学校

    Role(s):Lecturer, Informant

    中華人民共和国深セン明徳実験学校  学内見学とセミナー高校3年生  2019.10

  3. 長野県飯田高等学校の進路研修

    Role(s):Appearance, Planner

    長野県飯田高等学校  高校2年生進路研修  2019.9

  4. 名古屋大学オープンキャンパス研究紹介

    Role(s):Informant, Planner

    名古屋大学  名古屋大学オープンキャンパス  2019.8

Media Coverage 1

  1. 体内のマンノース濃度を保つ仕組みを解明:進化の過程で選択された糖代謝経路 Internet

    名古屋大学広報および筑波大学広報  共同プレスリリース  https://www.nagoya-u.ac.jp/about-nu/public-relations/researchinfo/upload_images/20210216_agr1.pdf  2021.2

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    Author:Other 

Academic Activities 22

  1. International Conference of Sialoglycosciences Organizer International contribution

    Role(s):Planning, management, etc.

    International Conference Sialoglycosciences  2022.9

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    Type:Competition, symposium, etc. 

  2. Associate Editor of Glycobiology International contribution

    Role(s):Planning, management, etc., Review, evaluation

    Socity for Glycobiology  2021.1

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    Type:Scientific advice/Review 

  3. 第38回日本糖質学会年会(日本糖質学会創設40周年記念大会) International contribution

    Role(s):Planning, management, etc.

    北島健  2019.8

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    Type:Academic society, research group, etc. 

  4. Editorial Board of the Journal Biological Chemistry International contribution

    Role(s):Review, evaluation, Peer review

    American Society of Biochemistry and Molecular Biology  2017.4

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    Type:Peer review 

  5. 日本農芸化学会中部支部会評議員 International contribution

    Role(s):Planning, management, etc., Review, evaluation

    日本農芸化学会中部支部  2020.4 - 2021.3

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    Type:Academic society, research group, etc. 

  6. 糖鎖科学中部拠点事務局 International contribution

    Role(s):Planning, management, etc., Review, evaluation

    糖鎖科学名古屋拠点  2020.4 - 2021.3

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    Type:Academic society, research group, etc. 

  7. 日本生化学会理事 International contribution

    Role(s):Planning, management, etc., Review, evaluation

    日本生化学会  2015.4 - 2017.3

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    Type:Academic society, research group, etc. 

  8. 日本生化学会中部支部支部長 International contribution

    Role(s):Planning, management, etc.

    日本生化学会中部支部  2015.4 - 2017.3

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    Type:Academic society, research group, etc. 

  9. 日本生化学会評議員 International contribution

    Role(s):Planning, management, etc., Review, evaluation

    日本生化学会  2011.4

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    Type:Academic society, research group, etc. 

  10. 日本糖鎖科学コンソーシアム常任幹事 International contribution

    Role(s):Planning, management, etc., Review, evaluation

    日本糖鎖科学コンソーシアム  2010.4

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    Type:Academic society, research group, etc. 

  11. 日本学術振興会

    Role(s):Peer review

    日本学術振興会  2010.4

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    Type:Peer review 

  12. International Glycoconjugate Organization Committee National Representative International contribution

    Role(s):Planning, management, etc., Review, evaluation

    2010.4 - 2017.3

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    Type:Academic society, research group, etc. 

  13. Zygote

    Role(s):Planning, management, etc., Peer review

    Cambridge Universirty Press  2010.1 - 2013.12

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    Type:Peer review 

  14. The Journal of Biochemistry International contribution

    Role(s):Planning, management, etc., Peer review

    2008.4 - 2012.3

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    Type:Peer review 

  15. 日本糖質学会理事 International contribution

    Role(s):Planning, management, etc., Review, evaluation

    日本糖質学会  2007.7

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    Type:Academic society, research group, etc. 

  16. Editorial Board Member of Glycoconjugate Journal International contribution

    Role(s):Review, evaluation, Peer review

    Society for Glycobiology  2007.4

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    Type:Peer review 

  17. Editorial Board Member of Glycobiology International contribution

    Role(s):Review, evaluation

    Society for Glycobiology  2006.1

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    Type:Scientific advice/Review 

  18. 日本科学技術振興機構

    Role(s):Review, evaluation, Peer review

    日本科学技術振興機構  2004.4 - 2012.3

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    Type:Peer review 

  19. Forum: Carbohydrate Coming of Age International contribution

    Role(s):Planning, management, etc., Review, evaluation

    Forum: Carbohydrate Coming of Age  2001.4 - 2007.3

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    Type:Academic society, research group, etc. 

  20. The Journal of Biochemistry International contribution

    Role(s):Planning, management, etc.

    Associate Editor  2001.4 - 2005.3

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    Type:Scientific advice/Review 

  21. Trends in Glycoscience and Glycotechnology International contribution

    Role(s):Planning, management, etc.

    Editorial Board Member  2000.1 - 2017.12

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    Type:Peer review 

  22. 日本糖質学会評議員 International contribution

    Role(s):Planning, management, etc., Review, evaluation

    日本糖質学会  1999.7

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    Type:Academic society, research group, etc. 

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