論文 - 邊見 久
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Identification and Characterization of a Novel d-Branched-Chain Amino Acids Importer from Lactobacillus Fermentum. 査読有り
Aoki K, Mutaguchi Y, Hemmi H, Yoshimura T, Ito T
Chembiochem : a European journal of chemical biology 頁: e202401075 2025年2月
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Yoshida, R; Motoyama, K; Ito, T; Hemmi, H
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 729 巻 頁: 150349 2024年10月
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Identification of YigL as a PLP/PNP phosphatase in <i>Escherichia coli</i> 査読有り
Matsuo, H; Yamada, N; Hemmi, H; Ito, T
APPLIED AND ENVIRONMENTAL MICROBIOLOGY 90 巻 ( 9 ) 頁: e0127024 2024年9月
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Kanno, K; Kuriki, R; Yasuno, Y; Shinada, T; Ito, T; Hemmi, H
APPLIED AND ENVIRONMENTAL MICROBIOLOGY 90 巻 ( 8 ) 頁: e0110624 2024年8月
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古細菌型メバロン酸経路-その特徴と代謝工学的な応用の可能性- 招待有り
邊見 久
生物工学会誌 101 巻 ( 11 ) 頁: 583 - 586 2023年11月
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A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway 査読有り
Mutsumi Komeyama, Kohsuke Kanno, Hiroyuki Mino, Yoko Yasuno, Tetsuro Shinada, Tomokazu Ito, Hisashi Hemmi
Frontiers in Microbiology 14 巻 頁: 1150353 2023年3月
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d-amino acid auxotrophic Escherichia coli strain for in vivo functional cloning of novel d-amino acid synthetic enzyme. 査読有り
Ito T, Muto N, Sakagami H, Tanaka M, Hemmi H, Yoshimura T
FEBS journal 2023年1月
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Identification and functional analysis of a new type of Z,E-mixed prenyl reductase from mycobacteria 査読有り
Abe Tohru, Hakamata Mariko, Nishiyama Akihito, Tateishi Yoshitaka, Matsumoto Sohkichi, Hemmi Hisashi, Ueda Daijiro, Sato Tsutomu
FEBS JOURNAL 289 巻 ( 16 ) 頁: 4981 - 4997 2022年8月
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Crystal structure of mevalonate 3,5-bisphosphate decarboxylase reveals insight into the evolution of decarboxylases in the mevalonate metabolic pathways 査読有り 国際共著
Aoki Mizuki, Vinokur Jeffrey, Motoyama Kento, Ishikawa Rino, Collazo Michael, Cascio Duilio, Sawaya Michael R., Ito Tomokazu, Bowie James U., Hemmi Hisashi
JOURNAL OF BIOLOGICAL CHEMISTRY 298 巻 ( 7 ) 頁: 102111 2022年7月
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Identification and biochemical characterization of a heteromeric cis-prenyltransferase from the thermophilic archaeon Archaeoglobus fulgidus 査読有り
Sompiyachoke Kitty, Nagasaka Arisa, Ito Tomokazu, Hemmi Hisashi
JOURNAL OF BIOCHEMISTRY 171 巻 ( 6 ) 頁: 641 - 651 2022年5月
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Identification and characterization of a serine racemase in the silkworm <i>Bombyx mori</i> 査読有り
Tanaka, Y; Yoshimura, T; Hakamata, M; Saito, C; Sumitani, M; Sezutsu, H; Hemmi, H; Ito, T
JOURNAL OF BIOCHEMISTRY 172 巻 ( 1 ) 頁: 17 - 28 2022年3月
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Mechanism of Pyridoxine 5 '-Phosphate Accumulation in Pyridoxal 5 '-Phosphate-Binding Protein Deficiency 査読有り 国際共著
Ito Tomokazu, Ogawa Honoka, Hemmi Hisashi, Downs Diana M., Yoshimura Tohru
JOURNAL OF BACTERIOLOGY 204 巻 ( 3 ) 頁: e0052121 2022年3月
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Isopentenyl diphosphate/dimethylallyl diphosphate-specific Nudix hydrolase from the methanogenic archaeon Methanosarcina mazei 査読有り
Ishibashi Yumi, Matsushima Natsumi, Ito Tomokazu, Hemmi Hisashi
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 86 巻 ( 2 ) 頁: 246 - 253 2022年1月
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Evolution and properties of alanine racemase from Synechocystis sp. PCC6803 査読有り
Ashida Hiroyuki, Murakami Kaho, Inagaki Kenji, Sawa Yoshihiro, Hemmi Hisashi, Iwasaki Yugo, Yoshimura Tohru
JOURNAL OF BIOCHEMISTRY 171 巻 ( 4 ) 頁: 421 - 428 2021年12月
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Total Synthesis and Structure Confirmation of trans-Anhydromevalonate-5-phosphate, a Key Biosynthetic Intermediate of the Archaeal Mevalonate Pathway 査読有り
Yasuno Yoko, Nakayama Atsushi, Saito Kai, Kitsuwa Kohei, Okamura Hironori, Komeyama Mutsumi, Hemmi Hisashi, Shinada Tetsuro
JOURNAL OF NATURAL PRODUCTS 84 巻 ( 10 ) 頁: 2749 - 2754 2021年10月
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Urinary l-erythro-β-hydroxyasparagine-a novel serine racemase inhibitor and substrate of the Zn2+-dependent d-serine dehydratase. 査読有り
Ito T, Tono M, Kitaura Y, Hemmi H, Yoshimura T
Bioscience reports 41 巻 ( 4 ) 2021年4月
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A versatile cis-prenyltransferase from Methanosarcina mazei catalyzes both C- and O-prenylations 査読有り
Okada Miyako, Unno Hideaki, Emi Koh-Ichi, Matsumoto Mayuko, Hemmi Hisashi
JOURNAL OF BIOLOGICAL CHEMISTRY 296 巻 頁: 100679 2021年4月
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古細菌型メバロン酸経路の発見 招待有り 査読有り
邊見 久
生化学 93 巻 ( 2 ) 頁: 221 - 224 2021年4月
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Mechanism of eukaryotic serine racemase-catalyzed serine dehydration 査読有り
Ito Tomokazu, Matsuoka Mai, Goto Masaru, Watanabe Soichiro, Mizobuchi Taichi, Matsushita Kazuma, Nasu Ryoma, Hemmi Hisashi, Yoshimura Tohru
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1868 巻 ( 9 ) 頁: 140460 2020年9月
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Reconstruction of the "Archaeal" Mevalonate Pathway from the Methanogenic Archaeon Methanosarcina mazei in Escherichia coli Cells 査読有り
Yoshida Ryo, Yoshimura Tohru, Hemmi Hisashi
APPLIED AND ENVIRONMENTAL MICROBIOLOGY 86 巻 ( 6 ) 2020年3月
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Inhibition of glycine cleavage system by pyridoxine 5 '-phosphate causes synthetic lethality in glyA yggS and serA yggS in Escherichia coli 査読有り 国際共著
Ito Tomokazu, Hori Ran, Hemmi Hisashi, Downs Diana M., Yoshimura Tohru
MOLECULAR MICROBIOLOGY 113 巻 ( 1 ) 頁: 270 - 284 2020年1月
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Construction of an artificial biosynthetic pathway for hyperextended archaeal membrane lipids in the bacterium Escherichia coli 査読有り
Yoshida Ryo, Hemmi Hisashi
SYNTHETIC BIOLOGY 5 巻 ( 1 ) 頁: ysaa018 2020年
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A heteromeric cis-prenyltransferase is responsible for the biosynthesis of glycosyl carrier lipids in Methanosarcina mazei 査読有り
Emi Koh-ichi, Sompiyachoke Kitty, Okada Miyako, Hemmi Hisashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 520 巻 ( 2 ) 頁: 291 - 296 2019年12月
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Conserved Pyridoxal 5 '-Phosphate-Binding Protein YggS Impacts Amino Acid Metabolism through Pyridoxine 5 '-Phosphate in Escherichia coli 査読有り 国際共著
Ito Tomokazu, Yamamoto Kana, Hori Ran, Yamauchi Ayako, Downs Diana M., Hemmi Hisashi, Yoshimura Tohru
APPLIED AND ENVIRONMENTAL MICROBIOLOGY 85 巻 ( 11 ) 2019年6月
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Conversion of Mevalonate 3-Kinase into 5-Phosphomevalonate 3-Kinase by Single Amino Acid Mutations 査読有り
Motoyama Kento, Sobue Fumiaki, Kawaide Hiroshi, Yoshimura Tohru, Hemmi Hisashi
APPLIED AND ENVIRONMENTAL MICROBIOLOGY 85 巻 ( 9 ) 2019年5月
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Modified mevalonate pathway of the archaeon <i>Aeropyrum pernix</i> proceeds via <i>trans</i>-anhydromevalonate 5-phosphate. 査読有り
Hayakawa H, Motoyama K, Sobue F, Ito T, Kawaide H, Yoshimura T, Hemmi H
Proceedings of the National Academy of Sciences of the United States of America 115 巻 ( 40 ) 頁: 10034-10039 2018年9月
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D-Serine Metabolism and Its Importance in Development of Dictyostelium discoideum 査読有り
Ito Tomokazu, Hamauchi Natsuki, Hagi Taisuke, Morohashi Naoya, Hemmi Hisashi, Sato Yukie G., Saito Tamao, Yoshimura Tohru
FRONTIERS IN MICROBIOLOGY 9 巻 頁: 784 2018年4月
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Production of Ophthalmic Acid Using Engineered Escherichia coli 査読有り
Ito Tomokazu, Tokoro Maiko, Hori Ran, Hemmi Hisashi, Yoshimura Tohru
APPLIED AND ENVIRONMENTAL MICROBIOLOGY 84 巻 ( 7 ) 2018年4月
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Biosynthetic machinery for C-25,C-25-diether archaeal lipids from the hyperthermophilic archaeon Aeropyrum pernix 査読有り
Yoshida Ryo, Yoshimura Tohru, Hemmi Hisashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 497 巻 ( 1 ) 頁: 87-92 2018年2月
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Utilization of an intermediate of the methylerythritol phosphate pathway, (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate, as the prenyl donor substrate for various prenyltransferases 査読有り
Hayashi Yoshifumi, Ito Tomokazu, Yoshimura Tohru, Hemmi Hisashi
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 82 巻 ( 6 ) 頁: 993-1002 2018年
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Occurrence of the (2R,3S) -Isomer of 2-Amino-3,4-dihydroxybutanoic Acid in the Mushroom Hypsizygus marmoreus 査読有り
Ito Tomokazu, Yu Zhuoer, Yoshino Issei, Hirozawa Yurina, Yamamoto Kana, Shinoda Kiyotugu, Watanabe Akira, Hemmi Hisashi, Asada Yasuhiko, Yoshimura Tohru
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 65 巻 ( 30 ) 頁: 6131-6139 2017年8月
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Identification of enzymes involved in the mevalonate pathway of Flavobacterium johnsoniae 査読有り
Hayakawa Hajime, Sobue Fumiaki, Motoyama Kento, Yoshimura Tohru, Hemmi Hisashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 487 巻 ( 3 ) 頁: 702-708 2017年6月
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A Single Amino Acid Mutation Converts (R)-5-Diphosphomevalonate Decarboxylase into a Kinase 査読有り
Motoyama Kento, Unno Hideaki, Hattori Ai, Takaoka Tomohiro, Ishikita Hiroshi, Kawaide Hiroshi, Yoshimura Tohru, Hemmi Hisashi
JOURNAL OF BIOLOGICAL CHEMISTRY 292 巻 ( 6 ) 頁: 2457-2469 2017年2月
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メバロン酸経路の多様性 招待有り
邊見 久
バイオサイエンスとインダストリー 74 巻 ( 1 ) 頁: 15-20 2016年
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大腸菌をプラットフォームとしたアーキア膜脂質生合成研究 招待有り
邊見 久
酵素工学ニュース ( 76 ) 頁: 11-15 2016年
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A cis-prenyltransferase from Methanosarcina acetivorans catalyzes both head-to-tail and nonhead-to-tail prenyl condensation 査読有り
Ogawa, T., Emi, K., Koga, K., Yoshimura, T. & Hemmi, H.
FEBS Journal 283 巻 頁: 2369-2383 2016年
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Ophthalmic acid accumulation in an Escherichia coli mutant lacking the conserved pyridoxal 5'-phosphate-binding protein YggS 査読有り
Ito, T., Yamauchi, A., Hemmi, H. & Yoshimura, T.
Journal of Bioscience and Bioengineering 122 巻 頁: 689-693 2016年
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A new member of MocR/GabR-type PLP-binding regulator of D-alanyl-D-alanine ligase in Brevibacillus brevis 査読有り
Takenaka, T., Ito, T., Miyahara, I., Hemmi, H. & Yoshimura T.
FEBS Journal 282 巻 頁: 4201-4217 2015年
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Role of the aminotransferase domain in Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator 査読有り
Okuda, K., Kato, S., Ito, T., Shiraki, S., Kawase, Y., Goto, M., Kawashima, S., Hemmi, H., Fukada H. & Yoshimura T.
Molecular Microbiology 95 巻 ( 2 ) 頁: 245-257 2015年
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Domain characterization of Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator 査読有り
Okuda, K., Ito, T., Goto, M., Takenaka, T., Hemmi, H. & Yoshimura T.
Journal of Biochemistry 158 巻 ( 3 ) 頁: 225-234 2015年
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A highly selective biosynthetic pathway to non-natural C50 carotenoids assembled from moderately selective enzymes 査読有り
Furubayashi, M., Ikezumi, M., Takaichi, S., Maoka, T., Hemmi, H., Ogawa, T., Saito, K., Tobias, A.V. & Umeno, D.
Nature Communications 6 巻 頁: 7534 2015年
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A phytoene desaturase homolog gene from the methanogenic archaean Methanosarcina acetivorans is responsible for hydroxyarchaeol biosynthesis 査読有り
Mori, T., Isobe, K., Ogawa, T., Yoshimura, T. & Hemmi, H.
Biochemical and Biophysical Research Communications 466 巻 頁: 186-191 2015年
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In vivo formation of the protein disulfide bond that enhances the thermostability of diphosphomevalonate decarboxylase, an intracellular enzyme from the hyperthermophilic archaean Sulfolobus solfataricus 査読有り
Hattori, A., Unno, H., Goda, S., Motoyama, K., Yoshimura, T. & Hemmi, H.
Journal of Bacteriology 197 巻 ( 21 ) 頁: 3463-3471 2015年
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PEGylated D-serine dehydratase as a D-serine reducing agent 査読有り
Ito, T., Takada, H., Isobe, K., Suzuki, M., Kitaura, Y., Hemmi, H., Matsuda, T. & Yoshimura T.
Journal of Pharmaceutical and Biomedical Analysis 116 巻 頁: 34-39 2015年
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Reaction mechanism of Zn2+-dependent D-serine dehydratase: role of a conserved tyrosine residue interacting with pyridine ring nitrogen of pyridoxal 5'-phosphate 査読有り
Ito, T., Matsuoka, M., Koga, K., Hemmi, H. & Yoshimura, T.
Journal of Biochemistry 156 巻 頁: 173-180 2014年
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A novel geranylgeranyl reductase from the methanogenic archaeon Methanosarcina acetivorans displays unique regiospecificity 査読有り
Ogawa, T., Isobe, K., Mori, T., Asakawa, S., Yoshimura, T. & Hemmi, H.
FEBS Journal 281 巻 頁: 3165-3176 2014年
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(R)-mevalonate 3-phosphate is an intermediate of the mevalonate pathway in Thermoplasma acidophilum 査読有り
Azami, Y., Hattori, A., Nishimura, H., Kawaide, H., Yoshimura, T. & Hemmi, H.
Journal of Biological Chemistry 289 巻 頁: 15957-15967 2014年
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Geranylgeranyl reductase and ferredoxin from Methanosarcina acetivorans are required for the synthesis of fully reduced archaeal membrane lipid in Escherichia coli cells 査読有り
Isobe, K., Ogawa, T., Hirose, K., Yokoi, T., Yoshimura, T. & Hemmi, H.
Journal of Bacteriology 196 巻 頁: 417-423 2014年
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Conserved pyridoxal protein that regulates Ile nad Val metabolism 査読有り
Ito, T., Iimori, J., Takayama, S., Moriyama, A., Yamauchi, A., Hemmi, H. & Yoshimura, T.
Journal of Bacteriology 195 巻 頁: 5439-5449 2013年
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Substrate specificity of undecaprenyl diphosphate synthase from the hyperthermophilic archaeon Aeropyrum pernix 査読有り
Mori, T., Ogawa, T., Yoshimura, T. & Hemmi, H.
Biochemical and Biophysical Research Communications 436 巻 頁: 230-234 2013年
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Biochemical evidence supporting the presence of the classical mevalonate pathway in the thermoacidophilic archaeon Sulfolobus solfataricus 査読有り
Nishimura, H., Azami, Y., Miyagawa, M., Hashimoto, C., Yoshimura, T. & Hemmi, H.
Journal of Biochemistry 153 巻 頁: 415-420 2013年
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Catalytic mechanism of serine racemase from Dictyostelium discoideum 査読有り
Ito, T., Maekawa, M., Hayashi, S., Goto, M., Hemmi, H. & Yoshimura, T.
Amino Acids 44 巻 頁: 1073-1084 2013年
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Archaeal phospholipid biosynthetic pathway reconstructed in Escherichia coli 査読有り
Yokoi, T., Isobe, K., Yoshimura, T. & Hemmi, H.
Archaea 2012 巻 頁: ID 438931 2012年
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Substrate-induced change in the quaternary structure of type 2 isopentenyl diphosphate isomerase from Sulfolobus shibatae 査読有り
Nakatani, H., Goda, S., Unno, H., Nagai, T., Yoshimura, T. & Hemmi, H.
Journal of Bacteriology 194 巻 頁: 3216-3224 2012年
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Quantitative analyses of the behavior of exogenously added bacteria during an acidulocomposting process 査読有り
Suematsu, T., Yamashita, S., Hemmi, H., Yoshinari, A., Shimoyama, T., Nakayama, T. & Nishino, T.
Journal of Bioscience and Bioengineering 114 巻 頁: 70-72 2012年
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Metal ion dependency of serine rasemase from Dictyostelium discoideum 査読有り
Ito, T., Murase, H., Maekawa, M., Goto, M., Hayashi, S., Saito, H., Maki, M., Hemmi, H., & Yoshimura, T.
Amino Acids 43 巻 頁: 1567-1576 2012年
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Role of Zinc Ion for Catalytic Activity in D-Serine Dehydratase from Saccharomyces cerevisiae 査読有り
Ito, T., Koga, K., Hemmi, H., & Yoshimura, T.
FEBS Journal. 279 巻 頁: 612-624 2012年
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Lysine racemase from a lactic acid bacterium, Oenococcus oeni: Structural basis of substrate specificity 査読有り
Kato, S., Hemmi, H. & Yoshimura, T.
Journal of Biochemistry 152 巻 頁: 505-508 2012年
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Enzymatic assay for D-aspartic acid using D-aspartate oxidase and oxaloacetate decarboxylase 査読有り
Kato, S., Ikuta, T., Hemmi, H., Takahashi, S., Kera, Y & Yoshimura, T.
Bioscience, Biotechnology, and Biochemistry 76 巻 頁: 2150-2152 2012年
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Covalent modification of reduced flavin mononucleotide in type-2 isopentenyl diphosphate isomerase by active-site-directed inhibitors 査読有り
Nagai, T., Unno, H., Janczak, M.W., Yoshimura, T., Poulter, C.D. & Hemmi, H.
Proceedings of the National Academy of Sciences of the United States of America 108 巻 頁: 20461-20466 2011年
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Simultaneous determination of D-amino acids by the coupling method of D-amino acid oxidase with high-performance liquid chromatography 査読有り
Kato, S., Kito, Y., Hemmi, H., & Yoshimura, T.
Journal of Chromatography B 111 巻 頁: 104-108 2011年
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Connected cavity structure enables prenyl elongation across the dimer interface in mutated geranylfarnesyl diphosphate synthase from Methanosarcina mazei 査読有り
Ogawa, T., Yoshimura, T. & Hemmi, H.
Biochemical and Biophysical Research Communications 409 巻 頁: 333-337 2011年
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Structure and mutation analysis of archaeal geranylgeranyl reductase 査読有り
Sasaki, D., Fujihashi, M., Iwata, Y., Murakami, M., Yoshimura, T., Hemmi, H. & Miki, K.
Journal of Molecular Biology 409 巻 頁: 543-557 2011年
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Alterations in D-amino acid concentrations and microbial community structures during the fermentation of red and white wines
Kato, S., Ishihara, T., Hemmi, H., Kobayashi, H. & Yoshimura, T.
Journal of Bioscience and Bioengineering 111 巻 頁: 104-108 2011年
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ユニークなフラビン酵素:タイプ2イソペンテニル二リン酸イソメラーゼ 招待有り
邊見 久
生化学 83 巻 ( 4 ) 頁: 304-307 2011年
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古細菌イソプレノイド生合成に関わるタイプ2イソペンテニル二リン酸イソメラーゼにおけるフラビン補酵素の特異な機能 招待有り 査読有り
邊見 久
ビタミン 85 巻 ( 1 ) 頁: 1-8 2011年
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Bacillus subtilis spore coat protein LipC is a phospholipase B 査読有り
Masayama, A., Kato, S., Terashima, T., Molgaard, A., Hemmi, H., Yoshimura, T. & Moriyama, R.
Bioscience, Biotechnology, and Biochemistry 74 巻 頁: 24-30 2010年
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イソプレノイド代謝にみるフラビン補酵素のユニークな機能
邊見 久
バイオサイエンスとインダストリー 68 巻 ( 6 ) 頁: 421-423 2010年
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フラビン酵素の新機能?
邊見 久
生物工学会誌 88 巻 ( 3 ) 頁: 122 2010年
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アーキアにおける膜脂質生合成 招待有り 査読有り
邊見 久
化学と生物 48 巻 ( 9 ) 頁: 614-621 2010年
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A highly sensitive enzymatic assay for D- and total serine detection using D-serine dehydratase from Saccharomyces cerevisiae 査読有り
Naka, T., Ito, T., Hemmi, H. & Yoshimura, T.
Journal of Molecular Catalysis B: Enzymatic 67 巻 頁: 150-154 2010年
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Biochemical analysis of a novel lipolytic enzyme YvdO from Bacillus subtilis 168 査読有り
Kato, S., Yoshimura, T., Hemmi, H. & Moriyama, R.
Bioscience, Biotechnology, and Biochemistry 74 巻 頁: 701-706 2010年
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Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution 査読有り
Ogawa, T., Yoshimura, T. & Hemmi, H.
Biochemical and Biophysical Research Communications 393 巻 頁: 16-20 2010年
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Flavin's new role as a general acid-base catalyst with no redox function in type 2 isopentenyl diphosphate isomerase 査読有り
Unno, H., Yamashita, S., Ikeda, Y., Sekiguchi, S., Yoshida, N., Yoshimura, T., Kusunoki, M., Nakayama, T., Nishino, T. & Hemmi, H.
Journal of Biological Chemistry 284 巻 頁: 9160-9167 2009年
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Physiological role of carbon dioxide in spore germination of Clostridium perfringens S40 査読有り
Kato, S., Masayama, A., Yoshimura, T., Hemmi, H., Tsunoda, H., Kihara, T. & Moriyama, R.
Journal of Bioscience and Bioengineering 108 巻 頁: 477-483 2009年
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Polymerase chain reaction-denaturing gradient gel electrophoresis analysis of microbial community structure in landfill leachate 査読有り
Uchida, M., Hatayoshi, H., Syuku-nobe, A., Shimoyama, T., Nakayama, T., Okuwaki, A., Nishino, T. & Hemmi, H.
Journal of Hazardous Materials 164 巻 頁: 1503-1508 2009年
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Effect of mutagenesis at the region upstream from the G(Q/E) motif of three types of geranylgeranyl diphosphate synthase on product chain-length 査読有り
Noike, M., Katagiri, T., Nakayama, T., Nishino, T. & Hemmi, H.
Journal of Bioscience and Bioengineering 107 巻 頁: 235-239 2009年
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The implication of YggT of Escherichia coli in osmotic regulation 査読有り
Ito, T., Uozumi, N., Nakamura, T., Takayama, S., Matsuda, N., Aiba, H., Hemmi, H. & Yoshimura, T.
Journal of Bioscience and Bioengineering 73 巻 頁: 2698-2704 2009年
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A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae 査読有り
Ito, T., Hemmi, H., Kataoka, K., Mukai, Y. & Yoshimura, T.
Biochemical Journal 409 巻 頁: 399-406 2008年
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タイプ2イソペンテニル二リン酸イソメラーゼの反応機構 招待有り 査読有り
邊見 久
ビタミン 82 巻 ( 11 ) 頁: 581-588 2008年
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The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction 査読有り
Noike, M., Katagiri, T., Nakayama, T., Koyama, T., Nishino, T. & Hemmi, H.
FEBS Journal 275 巻 頁: 3921-3933 2008年
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Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl-donor, not a dead-end product 査読有り
Sato, S., Murakami, M., Yoshimura, T. & Hemmi, H.
Journal of Bacteriology 190 巻 頁: 3923-3929 2008年
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Geranylgeranyl reductase involved in the biosynthesis of archaeal membrane lipids in the hyperthermophilic archaeon Archaeoglobus fulgidus 査読有り
Murakami, M., Shibuya, K., Nakayama, T., Nishino, T., Yoshimura, T., Hemmi, H.
FEBS Journal 274 巻 頁: 805-814 2007年
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アーキアにおけるイソプレノイド脂質の生合成:生体化合物の進化の歴史は解明可能だろうか?
邊見 久
化学と生物 45 巻 ( 9 ) 頁: 596-598 2007年
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タイプ2イソペンテニル二リン酸イソメラーゼにおけるFMNの役割
邊見 久、吉村 徹
ビタミン 81 巻 ( 10 ) 頁: 504-506 2007年
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Enzyme assay of D-serine dehydratase from Saccharomyces cerevisiae 査読有り
Ito, T., Takahashi, K., Naka, T., Hemmi, H. & Yoshimura, T.
Analytical Biochemistry 371 巻 頁: 167-172 2007年
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Structural and kinetic evidence for an extended hydrogen-bonding network in catalysis of methyl group transfer 査読有り
Doukov, T.I., Hemmi, H., Drennan, C.L., Ragsdale, S.W.
Journal of Biological Chemistry 282 巻 頁: 6609-6618 2007年
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A novel lipolytic enzyme, YcsK (LipC), located in the spore coat of Bacillus subtilis, is involved in spore germination 査読有り
Masayama, A., Kuwana, R., Takamatsu, H., Hemmi, H., Yoshimura, T., Watabe, K., Moriyama, R.
Journal of Bacteriology 189 巻 頁: 2369-2375 2007年
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Total synthesis of geranylgeranylglyceryl phosphate enantiomers: substrates for characterization of 2,3-O-digeranylgeranylglyceryl phosphate synthase 査読有り
Zhang, H., Shibuya, K., Hemmi, H., Nishino, T. & Prestwich, G.D.
Organic Letters 8 巻 頁: 943-946 2006年
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Microbacterium natoriense sp. nov., a novel D-aminoacylase-producing bacterium isolated from soil in Natori, Japan 査読有り
Liu, J., Nakayama, T., Hemmi, H., Asano, Y., Tsuruoka, N., Shimomura, K., Nishijima, M. & Nishino, T.
International Journal of Systematic and Evolutionary Microbiology 55 巻 頁: 611-615 2005年
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Menaquinone-specific prenyl reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus 査読有り
Hemmi, H., Takahashi, Y., Shibuya, K., Nakayama, T. & Nishino, T.
Journal of Bacteriology 187 巻 頁: 1937-1944 2005年
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UDP-glucuronic acid: Anthocyanin glucuronosyltransferase from red daisy (Bellis perennis) flowers enzymology and phylogenetics of a novel glucuronosyltransferase involved in flower pigment biosynthesis 査読有り
Sawada, S., Suzuki, H., Ichimaida, F., Yamaguchi, M. A., Iwashita, T., Fukui, Y., Hemmi, H., Nishino, T. & Nakayama, T.
Journal of Biological Chemistry 280 巻 頁: 899-906 2005年
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Microbial diversity in bio-degradation and re-utilization processes of garbage 査読有り
Haruta, S., Nakayama, T., Nakamura, K., Hemmi, H., Ishii, M., Igarashi, Y. & Nishino, T.
Journal of Bioscience and Bioengineering 99 巻 頁: 1-11 2005年
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Molecular biological analysis of microflora in a garbage treatment process under thermoacidophilic conditions 査読有り
Hemmi, H., Shimoyama, T., Nakayama, T., Hoshi, K. & Nishino, T.
Journal of Bioscience and Bioengineering 97 巻 頁: 119-126 2004年
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Molecular cloning and characterization of a thermostable carboxylesterase from an archaeon, Sulfolobus shibatae DSMZ5389: a non-linear kinetic behavior of a hormone-sensitive lipase family enzyme 査読有り
Ejima, K., Liu, J., Oshima, Y., Hirooka, K., Shimanuki, S., Hemmi, H., Nakayama, T. & Nishino, T.
Journal of Bioscience and Bioengineering 98 巻 頁: 445-451 2004年
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(S)-2,3-Di-O-geranylgeranylglyceryl phosphate synthase from the thermoacidophilic archaeon Sulfolobus solfataricus. Molecular cloning and characterization of a membrane-intrinsic prenyltransferase involved in the biosynthesis of archaeal ether-linked membrane lipids 査読有り
Hemmi, H., Shibuya, K., Takahashi, Y., Nakayama, T. & Nishino, T.
Journal of Biological Chemistry 279 巻 頁: 50197-50203 2004年
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Catalytic mechanism of type 2 isopentenyl diphosphate:dimethylallyl diphosphate isomerase: verification of a redox role of the flavin cofactor in a reaction with no net redox change 査読有り
Hemmi, H., Ikeda, Y., Yamashita, S., Nakayama, T. & Nishino, T.
Biochemical and Biophysical Research Communications 322 巻 頁: 905-910 2004年
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Type 2 isopentenyl diphosphate isomerase from a thermoacidophilic archaeon Sulfolobus shibatae 査読有り
Yamashita, S., Hemmi, H., Ikeda, Y., Nakayama, T. & Nishino, T.
European Journal of Biochemistry 271 巻 頁: 1087-1093 2004年
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Acidulocomposting, an accelerated composting process of garbage under thermoacidophilic conditions for prolonged periods 査読有り
Nishino, T., Nakayama, T., Hemmi, H., Shimoyama, T., Yamashita, S., Akai, M., Kanagawa, T., & Hoshi, K.
Journal of Environmental Biotechnology 3 巻 頁: 33-36 2003年
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An alternative mechanism of product chain-length determination in type III geranylgeranyl diphosphate synthase 査読有り
Hemmi, H., Noike, M., Nakayama, T. & Nishino, T.
European Journal of Biochemistry 270 巻 頁: 2186-2194 2003年
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Fusion-type lycopene β-cyclase from a thermoacidophilic archaeon Sulfolobus solfataricus 査読有り
Hemmi, H., Ikejiri, S., Nakayama, T. & Nishino, T.
Biochemical and Biophysical Research Communications 305 巻 頁: 586-591 2003年
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Introduction of the archaebacterial geranylgeranyl pyrophosphate synthase gene into Chlamydomonas reinhardtii chloroplast 査読有り
Fukusaki, E. I., Nishikawa, T., Kato, K., Shinmyo, A., Hemmi, H., Nishino, T. & Kobayashi, A.
Journal of Bioscience and Bioengineering 95 巻 頁: 283-287 2003年
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Collagenolytic serine-carboxyl proteinase from Alicyclobacillus sendaiensis strain NTAP-1: Purification, characterization, gene cloning, and heterologous expression 査読有り
Tsuruoka, N., Nakayama, T., Ashida, M., Hemmi, H., Nakao, M., Minakata, H., Oyama, H., Oda, K. & Nishino, T.
Applied and Environmental Microbiology 69 巻 頁: 162-169 2003年
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Alicyclobacillus sendaiensis sp nov., a novel acidophilic, slightly thermophilic species isolated from soil in Sendai, Japan 査読有り
Tsuruoka, N., Isono, Y., Shida, O., Hemmi, H., Nakayama, T. & Nishino, T.
International Journal of Systematic and Evolutionary Microbiology 53 巻 頁: 1081-1084 2003年
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Altering the substrate chain-length specificity of an α-glucosidase 査読有り
Noguchi, A., Nakayama, T., Hemmi, H. & Nishino, T.
Biochemical and Biophysical Research Communications 304 巻 頁: 684-690 2003年
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Deciphering the molecular basis of the broad substrate specificity of α-glucosidase from Bacillus sp SAM1606 査読有り
Noguchi, A., Yano, M., Ohshima, Y., Hemmi, H., Inohara-Ochiai, M., Okada, M., Min, K. S., Nakayama, T. & Nishino, T.
Journal of Biochemistry 134 巻 頁: 543-550 2003年
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Deletion and insertion of a 192-residue peptide in the active-site domain of glycosyl hydrolase family-2 β-galactosidases 査読有り
Inohara-Ochiai, M., Hasegawa, S., Iguchi, S., Ashikari, T., Shibano, Y., Hemmi, H., Nakayama, T. & Nishino, T.
Journal of Bioscience and Bioengineering 93 巻 頁: 575-583 2002年
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Novel medium-chain prenyl diphosphate synthase from the thermo acidophilic archaeon Sulfolobus solfataticus 査読有り
Hemmi, H., Ikejiri, S., Yamashita, S. & Nishino, T.
Journal of Bacteriology 184 巻 頁: 615-620 2002年
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Novel sugar phosphotransferase system applicable to the efficient labeling of the compounds synthesized via the non-mevalonate pathway in Escherichia coli 査読有り
Hemmi, H., Yamashita, S., Nakayama, T. & Nishino, T.
Journal of Bioscience and Bioengineering 93 巻 頁: 515-518 2002年
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Change of product specificity of hexaprenyl diphosphate synthase from Sulfolobus solfataricus by introducing mimetic mutations 査読有り
Hemmi, H., Noike, M., Nakayama, T. & Nishino, T.
Biochemical and Biophysical Research Communications 297 巻 頁: 1096-1101 2002年
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Site-specific mutagenesis at positions 272 and 273 of the Bacillus sp SAM1606 α-glucosidase to screen mutants with altered specificity for oligosaccharide production by transglucosylation 査読有り
Okada, M., Nakayama, T., Noguchi, A., Yano, M., Hemmi, H., Nishino, T. & Ueda, T.
Journal of Molecular Catalysis B-Enzymatic 16 巻 頁: 265-274 2002年
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Dramatic changes in the substrate specificities of prenyltransferase by a single amino acid substitution 査読有り
Maki, Y., Komabayashi, M., Gotoh, Y., Ohya, N., Hemmi, H., Hirooka, K., Nishino, T. & Koyama, T.
Journal of Molecular Catalysis B-Enzymatic 19 巻 頁: 431-436 2002年
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Cloning, expression, and characterization of cis-polyprenyl diphosphate synthase from the thermoacidophilic archaeon Sulfolobus acidocaldarius 査読有り
Hemmi, H., Yamashita, S., Shimoyama, T., Nakayama, T. & Nishino, T.
Journal of Bacteriology 183 巻 頁: 401-404 2001年
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ホスミドマイシンー抗マラリア薬としての再発見
邊見 久
生物工学会誌 78 巻 ( 8 ) 頁: 338 2000年
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The role of histidine-114 of Sulfolobus acidocaldarius geranylgeranyl diphosphate synthase in chain-length determination 査読有り
Hirooka, K., Kato, T., Matsu-ura, J., Hemmi, H. & Nishino, T.
FEBS Letters 481 巻 頁: 68-72 2000年
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Zinc biosorption by a zinc-resistant bacterium, Brevibacterium sp strain HZM-1 査読有り
Taniguchi, J., Hemmi, H., Tanahashi, K., Amano, N., Nakayama, T. & Nishino, T.
Applied Microbiology and Biotechnology 54 巻 頁: 581-588 2000年
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An active-site mutation causes enhanced reactivity and altered regiospecificity of transglucosylation catalyzed by the Bacillus sp SAM1606 α-glucosidase 査読有り
Inohara-Ochiai, M., Okada, M., Nakayama, T., Hemmi, H., Ueda, T., Iwashita, T., Kan, Y., Shibano, Y., Ashikari, T. & Nishino, T.
Journal of Bioscience and Bioengineering 89 巻 頁: 431-437 2000年
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Identification of genes affecting lycopene formation in Escherichia coli transformed with carotenoid biosynthetic genes: Candidates for early genes in isoprenoid biosynthesis 査読有り
Hemmi, H., Ohnuma, S., Nagaoka, K. & Nishino, T.
Journal of Biochemistry 123 巻 頁: 1088-1096 1998年
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Overexpression of an archaeal geranylgeranyl diphosphate synthase in Escherichia coli cells 査読有り
Ohto, C., Nakane, H., Hemmi, H., Ohnuma, S., Obata, S. & Nishino, T.
Bioscience Biotechnology and Biochemistry 62 巻 頁: 1243-1246 1998年
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Recognition of allylic substrates in Sulfolobus acidocaldarius geranylgeranyl diphosphate synthase: Analysis using mutated enzymes and artificial allylic substrates 査読有り
Ohnuma, S., Hemmi, H., Koyama, T., Ogura, K. & Nishino, T.
Journal of Biochemistry 123 巻 頁: 1036-1040 1998年
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Effects of random mutagenesis in a putative substrate-binding domain of geranylgeranyl diphosphate synthase upon intermediate formation and substrate specificity 査読有り
Ohnuma, S., Hemmi, H., Ohto, C., Nakane, H. & Nishino, T.
Journal of Biochemistry 121 巻 頁: 696-704 1997年
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Conversion from farnesyl diphosphate synthase to geranylgeranyl diphosphate synthase by random chemical mutagenesis 査読有り
Ohnuma, S. I., Nakazawa, T., Hemmi, H., Hallberg, A. M., Koyama, T., Ogura, K. & Nishino, T.
Journal of Biological Chemistry 271 巻 頁: 10087-10095 1996年
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Conversion of product specificity of archaebacterial geranylgeranyl-diphosphate synthase - Identification of essential amino acid residues for chain length determination of prenyltransferase reaction 査読有り
Ohnuma, S., Hirooka, K., Hemmi, H., Ishida, C., Ohto, C. & Nishino, T.
Journal of Biological Chemistry 271 巻 頁: 18831-18837 1996年