Faculty Profiles - MIYATA, Takaki

Papers - MIYATA, Takaki

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CD206+ macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia Reviewed International coauthorship

Yuki Hattori, Daisuke Kato, Futoshi Murayama, Sota Koike, Hisa Asai, Ayato Yamasaki, Yu Naito, Ayano Kawaguchi, Hiroyuki Konishi, Marco Prinz, Takahiro Masuda, Hiroaki Wake, Takaki Miyata

Cell Reports Vol. 42 ( 2 ) page： 112092 - 112092 2023.2

Transient microglial absence assists postmigratory neurons in proper differentiation. Reviewed

Hattori Y, Naito Y, Tsugawa Y, Nonaka S, Wake H, Nagasawa T, Kawaguchi A, Miyata T.

Nature Communications Vol. 11 page： 1631 2020.4

Dorsal-to-Ventral Cortical Expansion Is Physically Primed by Ventral Streaming of Early Embryonic Preplate Neurons. Reviewed

Saito K, Okamoto M, Watanabe Y, Noguchi N, Nagasaka A, Nishina Y, Shinoda T, Sakakibara A, Miyata T

Cell Reports Vol. 29 ( 6 ) page： 1555 - 1567.e5 2019.11

Authorship：Last author,　Corresponding author Language：English Publisher：Cell Reports

Embryonic radial glial fibers that guide most neocortical neurons are ventrally deflected near their terminal, contributing to further expansion of the neocortical area. Saito et al. demonstrate that this fiber deflection is induced physically by a previously unrecognized ventral stream of the earliest generated preplate neurons.

DOI： 10.1016/j.celrep.2019.09.075

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Differentiating cells mechanically limit the interkinetic nuclear migration of progenitor cells to secure apical cytogenesis Reviewed

Watanabe Yuto, Kawaue Takumi, Miyata Takaki

DEVELOPMENT Vol. 145 ( 14 ) 2018.7

Elasticity-based boosting of neuroepithelial nucleokinesis via indirect energy transfer from mother to daughter. Reviewed

Shinoda T, Nagasaka A, Inoue Y, Higuchi R, Minami Y, Kato K, Suzuki M, Kondo T, Kawaue T, Saito K, Ueno N, Fukazawa Y, Nagayama M, Miura T, Adachi T, Miyata T

PLoS Biology Vol. 16 ( 4 ) page： e2004426 2018.4

TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding Reviewed

Okamoto, M., Namba, T., Shinoda, T., Kondo, T., Watanabe, T., Inoue, Y., Takeuchi, K., Enomoto, Y., Ota, K., Oda, K., Wada, Y., Sagou, K., Saito, K., Sakakibara, A., Kawaguchi, A., Nakajima, K., Adachi, T., Fujimori, T., Ueda, M. Hayashi, S., Kaibuchi, K., Miyata, T.

Nature Neuroscience Vol. 16 page： 1556-1566 2013.9

Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum. Reviewed

Miyata, T., Ono Y, Okamoto M, Masaoka M, Sakakibara A, Kawaguchi A, Hashimoto M, Ogawa M

Neural Development Vol. 5 ( 3 ) page： 1-21 2010

Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells. Reviewed

Miyata, T., Kawaguchi, A., Saito, K., Kawano, M., Muto, T., and Ogawa, M.

Development Vol. 131 page： 3133-3145 2004

Asymmetric inheritance of radial glial fibers by cortical neurons. Reviewed

Miyata, T., Kawaguchi, A., Okano, H., and Ogawa, M.

Neuron Vol. 31 page： 727-741 2001

NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Reviewed

Miyata, T., Maeda, T., and Lee, J.E.

Genes & Dev. Vol. 13 page： 1647-1652 1999

Regulation of Purkinje cell alignment by Reelin as revealed with CR-50 antibody. Reviewed

Miyata, T., Nakajima, K., Mikoshiba, K., and Ogawa, M.

J. Neurosci. Vol. 17 page： 3599-3609 1997

Quantitative in toto live imaging analysis of apical nuclear migration in the mouse telencephalic neuroepithelium Reviewed

Shimamura T, Miyata T.

Development, Growth, Differentiation 2024.12

A novel preparation for histological analyses of intraventricular macrophages in the embryonic brain Reviewed

Futoshi Murayama, Hisa Asai, Arya Kirone Patra, Hiroaki Wake, Takaki Miyata, Yuki Hattori

Development, Growth & Differentiation 2024.6

Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts Reviewed International journal

Haruko Watanabe-Takano, Katsuhiro Kato, Eri Oguri-Nakamura, Tomohiro Ishii, Koji Kobayashi, Takahisa Murata, Koichiro Tsujikawa, Takaki Miyata, Yoshiaki Kubota, Yasuyuki Hanada, Koichi Nishiyama, Tetsuro Watabe, Reinhard Fässler, Hirotaka Ishii, Naoki Mochizuki, Shigetomo Fukuhara

Nature Communications Vol. 15 ( 1 ) page： 1622 2024.3

Mechanical and physical interactions involving neocortical progenitor cells Invited Reviewed

Takaki Miyata

Neocortical Neurogenesis in Development and Evolution page： 119 - 136 2023.8

Analyzing the effect of cell rearrangement on Delta-Notch pattern formation

Toshiki Oguma, Hisako Takigawa-Imamura, Tomoyasu Shinoda, Shuntaro Ogura, Akiyoshi Uemura, Takaki Miyata, Philip K. Maini, Takashi Miura

Physical Review E Vol. 107 ( 6 ) page： 064404 2023.6

Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers. Reviewed

Katsuta H, Okuda S, Nagayama K, Machiyama H, Kidoaki S, Kato M, Sokabe M, Miyata T, Hirata H

iScience Vol. 26 ( 3 ) page： 106090 2023.3

Language：English Publishing type：Research paper (scientific journal) Publisher：iScience

Contractile force generated in actomyosin stress fibers (SFs) is transmitted along SFs to the extracellular matrix (ECM), which contributes to cell migration and sensing of ECM rigidity. In this study, we show that efficient force transmission along SFs relies on actin crosslinking by α-actinin. Upon reduction of α-actinin-mediated crosslinks, the myosin II activity induced flows of actin filaments and myosin II along SFs, leading to a decrease in traction force exertion to ECM. The fluidized SFs maintained their cable integrity probably through enhanced actin polymerization throughout SFs. A computational modeling analysis suggested that lowering the density of actin crosslinks caused viscous slippage of actin filaments in SFs and, thereby, dissipated myosin-generated force transmitting along SFs. As a cellular scale outcome, α-actinin depletion attenuated the ECM-rigidity-dependent difference in cell migration speed, which suggested that α-actinin-modulated SF mechanics is involved in the cellular response to ECM rigidity.

DOI： 10.1016/j.isci.2023.106090

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Functional Cooperation of α-Synuclein and Tau Is Essential for Proper Corticogenesis. Reviewed

Wang S, Fu Y, Miyata T, Matsumoto S, Shinoda T, Itoh K, Harada A, Hirotsune S, Jin M

The Journal of neuroscience : the official journal of the Society for Neuroscience Vol. 42 ( 37 ) page： 7031 - 7046 2022.9

Language：English Publisher：Journal of Neuroscience

Alpha-synuclein (aSyn) and tau are abundant multifunctional neuronal proteins, and their intracellular deposits have been linked to many neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Despite the disease relevance, their physiological roles remain elusive, as mice with knock-out of either of these genes do not exhibit overt phenotypes. To reveal functional cooperation, we generated aSyn2/2tau2/2 double-knock-out mice and characterized the functional cross talk between these proteins during brain development. Intriguingly, deletion of aSyn and tau reduced Notch signaling and accelerated interkinetic nuclear migration of G2 phase at early embryonic stage. This significantly altered the balance between the proliferative and neurogenic divisions of progenitor cells, resulting in an overproduction of early born neurons and enhanced neurogenesis, by which the brain size was enlarged during the embryonic stage in both sexes. On the other hand, a reduction in the number of neural progenitor cells in the middle stage of corticogenesis diminished subsequent gliogenesis in the aSyn2/2tau2/2 cortex. Additionally, the expansion and maturation of macroglial cells (astrocytes and oligodendrocytes) were suppressed in the aSyn2/2tau2/2 postnatal brain, which in turn reduced the male aSyn2/2tau2/2 brain size and cortical thickness to less than the control values. Our study identifies important functional cooperation of aSyn and tau during corticogenesis.

DOI： 10.1523/JNEUROSCI.0396-22.2022

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Border-associated macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia

Yuki Hattori, Daisuke Kato, Futoshi Murayama, Sota Koike, Yu Naito, Ayano Kawaguchi, Hiroaki Wake, Takaki Miyata

2022.7

Publisher：Cold Spring Harbor Laboratory

Summary

The relationships between microglia and macrophages, especially their lineage segregation outside the yolk sac, have been recently explored, providing a model in which a conversion from macrophages seeds microglia during brain development. However, spatiotemporal evidence to support such microglial seeding and to explain how it occurs has not been obtained. By cell tracking via slice culture, intravital imaging, and Flash tag-mediated labeling, we found that a group of intraventricular macrophages belonging to border-associated macrophages (BAMs), which were abundantly observed along the inner surface of the mouse cerebral wall at embryonic day 12, frequently entered the brain wall. Immunohistochemistry of the tracked cells showed that postinfiltrative BAMs acquired microglial properties while losing a macrophage phenotype. We also found that the intraventricular BAMs were supplied transepithelially from the roof plate. Thus, this study demonstrates that the “roof plate→ventricle→cerebral wall” route is an essential path for microglial colonization into the embryonic mouse brain.

DOI： 10.1101/2022.07.27.501563

Mid1 is associated with androgen-dependent axonal vulnerability of motor neurons in spinal and bulbar muscular atrophy. Reviewed

Ogura Y, Sahashi K, Hirunagi T, Iida M, Miyata T, Katsuno M

Cell death & disease Vol. 13 ( 7 ) page： 601 2022.7

Language：English Publisher：Cell Death and Disease

Spinal and bulbar muscular atrophy (SBMA) is an adult-onset hereditary neurodegenerative disease caused by the expansions of CAG repeats in the androgen receptor (AR) gene. Androgen-dependent nuclear accumulation of pathogenic AR protein causes degeneration of lower motor neurons, leading to progressive muscle weakness and atrophy. While the successful induction of SBMA-like pathology has been achieved in mouse models, mechanisms underlying motor neuron vulnerability remain unclear. In the present study, we performed a transcriptome-based screening for genes expressed exclusively in motor neurons and dysregulated in the spinal cord of SBMA mice. We found upregulation of Mid1 encoding a microtubule-associated RNA binding protein which facilitates the translation of CAG-expanded mRNAs. Based on the finding that lower motor neurons begin expressing Mid1 during embryonic stages, we developed an organotypic slice culture system of the spinal cord obtained from SBMA mouse fetuses to study the pathogenic role of Mid1 in SBMA motor neurons. Impairment of axonal regeneration arose in the spinal cord culture in SBMA mice in an androgen-dependent manner, but not in mice with non-CAG-expanded AR, and was either exacerbated or ameliorated by Mid1 overexpression or knockdown, respectively. Hence, an early Mid1 expression confers vulnerability to motor neurons, at least by inducing axonogenesis defects, in SBMA.

DOI： 10.1038/s41419-022-05001-6

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Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology. Reviewed

Tsujikawa K, Hamanaka K, Riku Y, Hattori Y, Hara N, Iguchi Y, Ishigaki S, Hashizume A, Miyatake S, Mitsuhashi S, Miyazaki Y, Kataoka M, Jiayi L, Yasui K, Kuru S, Koike H, Kobayashi K, Sahara N, Ozaki N, Yoshida M, Kakita A, Saito Y, Iwasaki Y, Miyashita A, Iwatsubo T, Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI), Ikeuchi T, Japanese Longitudinal Biomarker Study in PSP and CBD (JALPAC) Consortium, Miyata T, Sobue G, Matsumoto N, Sahashi K, Katsuno M

Science advances Vol. 8 ( 21 ) page： eabm5029 2022.5

Language：English Publisher：Science Advances

While amyloid-β lies upstream of tau pathology in Alzheimer’s disease, key drivers for other tauopathies, including progressive supranuclear palsy (PSP), are largely unknown. Various tau mutations are known to facilitate tau aggregation, but how the nonmutated tau, which most cases with PSP share, increases its propensity to aggregate in neurons and glial cells has remained elusive. Here, we identified genetic variations and protein abundance of filamin-A in the PSP brains without tau mutations. We provided in vivo biochemical evidence that increased filamin-A levels enhance the phosphorylation and insolubility of tau through interacting actin filaments. In addition, reduction of filamin-A corrected aberrant tau levels in the culture cells from PSP cases. Moreover, transgenic mice carrying human filamin-A recapitulated tau pathology in the neurons. Our data highlight that filamin-A promotes tau aggregation, providing a potential mechanism by which filamin-A contributes to PSP pathology.

DOI： 10.1126/sciadv.abm5029

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Embryonic Pericytes Promote Microglial Homeostasis and Their Effects on Neural Progenitors in the Developing Cerebral Cortex. Reviewed

Hattori Y, Itoh H, Tsugawa Y, Nishida Y, Kurata K, Uemura A, Miyata T

Journal of Neuroscience Vol. 42 ( 3 ) page： 362 - 376 2022.1

Authorship：Last author Language：English Publisher：The Journal of neuroscience : the official journal of the Society for Neuroscience

Multifaceted microglial functions in the developing brain, such as promoting the differentiation of neural progenitors and contributing to the positioning and survival of neurons, have been progressively revealed. Although previous studies have noted the relationship between vascular endothelial cells and microglia in the developing brain, little attention has been given to the importance of pericytes, the mural cells surrounding endothelial cells. In this study, we attempted to dissect the role of pericytes in microglial distribution and function in developing mouse brains. Our immunohistochemical analysis showed that approximately half of the microglia attached to capillaries in the cerebral walls. Notably, a magnified observation of the position of microglia, vascular endothelial cells and pericytes demonstrated that microglia were preferentially associated with pericytes that covered 79.8% of the total capillary surface area. Through in vivo pericyte depletion induced by the intraventricular administration of a neutralizing antibody against platelet-derived growth factor receptor (PDGFR)β (clone APB5), we found that microglial density was markedly decreased compared with that in control antibody-treated brains because of their low proliferative capacity. Moreover, in vitro coculture of isolated CD11b+ microglia and NG2+PDGFRα- cells, which are mostly composed of pericytes, from parenchymal cells indicated that pericytes promote microglial proliferation via the production of soluble factors. Furthermore, pericyte depletion by APB5 treatment resulted in a failure of microglia to promote the differentiation of neural stem cells into intermediate progenitors. Taken together, our findings suggest that pericytes facilitate microglial homeostasis in the developing brains, thereby indirectly supporting microglial effects on neural progenitors.SIGNIFICANCE STATEMENT This study highlights the novel effect of pericytes on microglia in the developing mouse brain. Through multiple analyses using an in vivo pericyte depletion mouse model and an in vitro coculture study of isolated pericytes and microglia from parenchymal cells, we demonstrated that pericytes contribute to microglial proliferation and support microglia in efficiently promoting the differentiation of neural stem cells into intermediate progenitors. Our present data provide evidence that pericytes function not only in the maintenance of cerebral microcirculation and blood brain barrier (BBB) integrity but also in microglial homeostasis in the developing cerebral walls. These findings will expand our knowledge and help elucidate the mechanism of brain development both in healthy and disease conditions.

DOI： 10.1523/JNEUROSCI.1201-21.2021

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Developmentally interdependent stretcher-compressor relationship between the embryonic brain and the surrounding scalp in the preosteogenic head. Reviewed

Tsujikawa K, Saito K, Nagasaka A, Miyata T

Developmental Dynamics 2022.1

Authorship：Last author,　Corresponding author Language：English Publisher：Developmental Dynamics

Background: How developing brains mechanically interact with the surrounding embryonic scalp layers (ie, epidermal and mesenchymal) in the preosteogenic head remains unknown. Between embryonic day (E) 11 and E13 in mice, before ossification starts in the skull vault, the angle between the pons and the medulla decreases, raising the possibility that when the elastic scalp is directly pushed outward by the growing brain and thus stretched, it recoils inward in response, thereby confining and folding the brain. Results: Stress-release tests showed that the E11-13 scalp recoiled and that the in vivo prestretch prerequisite for this recoil was physically dependent on the brain (pressurization at 77-93 Pa) and on actomyosin and elastin within the scalp. In scalp-removed heads, brainstem folding was reduced, and the spreading of ink from the lateral ventricle to the spinal cord that occurred in scalp-intact embryos (with >5 μL injection) was lost, suggesting roles of the embryonic scalp in brain morphogenesis and cerebrospinal fluid homeostasis. Under nonstretched conditions, scalp cell proliferation declined, while the restretching of the shrunken scalp rescued scalp cell proliferation. Conclusions: In the embryonic mouse head before ossification, a stretcher-compressor relationship elastically develops between the brain and the scalp, underlying their mechanically interdependent development.

DOI： 10.1002/dvdy.451

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Comparison of the Mechanical Properties Between the Convex and Concave Inner/Apical Surfaces of the Developing Cerebrum Reviewed

Frontiers in Cell and Developmental Biology Vol. 9 2021.7

A mouse model of microglia-specific ablation in the embryonic central nervous system. Reviewed

Li C, Konishi H, Nishiwaki K, Sato K, Miyata T, Kiyama H

Neuroscience Research 2021.6

Language：English Publisher：Neuroscience Research

Microglia, which migrate into the central nervous system (CNS) during the early embryonic stages, are considered to play various roles in CNS development. However, their embryonic roles are largely unknown, partly due to the lack of an effective microglial ablation system in the embryo. Here, we show a microglial ablation model by injecting diphtheria toxin (DT) into the amniotic fluid of Siglechdtr mice, in which the gene encoding DT receptor is knocked into the microglia-specific gene locus Siglech. We revealed that embryonic microglia were depleted for several days throughout the CNS, including some regions where microglia transiently accumulated, at any embryonic time point from embryonic day 10.5, when microglia colonize the CNS. This ablation system was specific for microglia because CNS-associated macrophages, which are a distinct population from microglia that reside in the CNS interfaces such as meninges, were unaffected. Therefore, this microglial ablation system is highly effective for studying the embryonic functions of microglia.

DOI： 10.1016/j.neures.2021.06.002

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大脳皮質の発生における力学 Invited

宮田卓樹

Vol. 38 page： 1510 - 1512 2020.12

Two-photon microscopic observation of cell-production dynamics in the developing mammalian neocortex in utero. Invited Reviewed

Kawasoe R, Shinoda T, Hattori Y, Nakagawa M, Pham TQ, Tanaka Y, Sagou K, Saito K, Katsuki S, Kotani T, Sano A, Fujimori T, Miyata T.

Development, Growth & Differentiation Vol. 62 page： 118 - 128 2020.1

Meflin-positive cancer-associated fibroblasts inhibit pancreatic carcinogenesis Invited Reviewed International coauthorship

Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, Ando K, Weng L, Ishihara S, Ponik SM, Conklin MH, Haga H, Nagasaka A, Miyata T, Matsuyama M, Kobayashi T, Fujii T, Yamada S, Yamaguchi J, Wang T, Woods SL, Worthley D, Shimamura T, Fujishiro M, Hirooka Y, Takahashi M, and Enomoto A

Cancer Research Vol. 79 page： 5367 - 5381 2019.10

Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction

Hara Akitoshi, Kobayashi Hiroki, Asai Naoya, Saito Shigeyoshi, Higuchi Takahiro, Kato Katsuhiro, Okumura Takahiro, Bando Yasuko K., Takefuji Mikito, Mizutani Yasuyuki, Miyai Yuki, Saito Shoji, Maruyama Shoichi, Maeda Keiko, Ouchi Noriyuki, Nagasaka Arata, Miyata Takaki, Mii Shinji, Kioka Noriyuki, Worthley Daniel L., Murohara Toyoaki, Takahashi Masahide, Enomoto Atsushi

CIRCULATION RESEARCH Vol. 125 ( 4 ) page： 414-430 2019.8

Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development Reviewed

Kawaue T., Shitamukai A., Nagasaka A., Tsunekawa Y., Shinoda T., Saito K., Terada R., Bilgic M., Miyata T., Matsuzaki F., Kawaguchi A.

NATURE COMMUNICATIONS Vol. 10 2019.6

[Production Logistics and Crowd Dynamics in the Developing Cerebral Cortex].

Miyata T

Brain and nerve = Shinkei kenkyu no shinpo Vol. 71 ( 4 ) page： 415-421 2019.4

大脳皮質形成の生産物流とクラウドダイナミクス Invited Reviewed

宮田卓樹

Vol. 71 page： 415 - 421 2019.4

Novel Development of Diabetic Retinopathy Research by Integrated Approach Reviewed

植村明嘉, 小椋俊太郎, 小椋俊太郎, 倉田薫里, 小峯祐美, 大矢恵, 井上奈緒美, 井上奈緒美, 小椋祐一郎, 高瀬弘嗣, 宮田卓樹, 福嶋葉子, 楠原仙太郎, 平島正則, 池田わたる, 南敬, 渋谷正史, 吉田富, MANN Fanny, 酒井秀人, 奈良裕美, YANCOPOULOS George D, WIEGAND Stanley J, KIM Pilhan, KOH Gou Young, 西川伸一

日本眼科学会雑誌 Vol. 123 ( 3 ) page： 312 - 336 2019

神経幹細胞による「他力」活用：集団的核移動の効率と細胞産生の安全 Invited Reviewed

篠田友靖，川上巧，宮田卓樹

Vol. 90 ( 6 ) page： 820 - 824 2018.12

Embryonic Neocortical Microglia Express Toll-Like Receptor 9 and Respond to Plasmid DNA Injected into the Ventricle: Technical Considerations Regarding Microglial Distribution in Electroporated Brain Walls.

Hattori Y, Miyata T

eNeuro Vol. 5 ( 6 ) 2018.11

Microglia extensively survey the developing cortex via the CXCL12/CXCR4 system to help neural progenitors to acquire differentiated properties.

Hattori Y, Miyata T

Genes to cells : devoted to molecular & cellular mechanisms 2018.8

Role of extrinsic mechanical force in the development of the RA-I tactile mechanoreceptor

Trung Quang Pham, Kawaue Takumi, Hoshi Takayuki, Tanaka Yoshihiro, Miyata Tataki, Sano Akihito

SCIENTIFIC REPORTS Vol. 8 2018.7

Synaptic transmission from subplate neurons controls radial migration of neocortical neurons

Ohtaka-Maruyama Chiaki, Okamoto Mayumi, Endo Kentaro, Oshima Minori, Kaneko Noe, Yura Kei, Okado Haruo, Miyata Takaki, Maeda Nobuaki

SCIENCE Vol. 360 ( 6386 ) page： 313-316 2018.4

Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury Reviewed

Jinnou H, Sawada M, Kawase K, Kaneko N, Herranz-Pérez V, Miyamoto T, Kawaue T, Miyata T, Tabata Y, Akaike T, García-Verdugo JM, Ajioka I, Saitoh S, Sawamoto K.

Cell Stem Cell. Vol. 22 ( 1 ) page： 128–137.e9 2018.1

Neural Progenitor Cells Undergoing Yap/Tead-Mediated Enhanced Self-Renewal Form Heterotopias More Easily in the Diencephalon than in the Telencephalon. Reviewed

Saito K, Kawasoe R, Sasaki H, Kawaguchi A, Miyata T.

Neurochemical Research Vol. 43 ( 1 ) page： 171–180 2018.1

神経上皮 – 大脳皮質の原構造におけるクラウドダイナミクスと組織力学 Reviewed

宮田卓樹

生体の科学 Vol. 68 ( 1 ) page： 4-8 2017.2

Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown. Reviewed

Ogura S, Kurata K, Hattori Y, Takase H, Ishiguro-Oonuma T, Hwang Y, Ahn S, Park I, Ikeda W, Kusuhara S, Fukushima Y, Nara H, Sakai H, Fujiwara T, Matsushita J, Ema M, Hirashima M, Minami T, Shibuya M, Takakura N, Kim P, Miyata T, Ogura Y, Uemura A.

JCI Insight. Vol. 2 page： e90905 2017.2

Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development. Reviewed

Matsunaga Y, Noda M, Murakawa H, Hayashi K, Nagasaka A, Inoue S, Miyata T, Miura T, Kubo K, and Nakajima K.

. Proc. Natl. Acad. Sci. U.S.A. 2017.2

Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics. Reviewed

Jin M, Pomp O, Shinoda T, Toba, Torisawa T, Furuta K, Oiwa K, Yasunaga T, Kitagawa D, Matsumura S, Miyata T, Tan TT, Reversade B and Hirotsune S.

Sci Rep. Vol. 7 page： 39902 2017.1

Differences in the mechanical properties of the developing cerebral cortical proliferative zone between mice and ferrets at both the tissue and single-cell levels. Reviewed

Nagasaka A, Shinoda T, Kawaue T, Suzuki T, Nagayama K, Matsumoto T, Ueno N, Kawaguchi A and Miyata T.

Front. Cell Dev. Biol. Vol. 4 page： 139 2016.11

Two-Photon imaging of DiO-labelled Meissner corpuscle in living mouse's fingertip. Reviewed

Pham TQ, Hoshi T, Tanaka Y, Sano A, Kawaue T, Miyata T.

IEEE Trans Haptics. Vol. 9 ( 4 ) page： 483-491 2016.6

PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex. Reviewed

Itoh, Y., Higuchi, M., Oishi, K., Kishi, Y., Okazaki, T., Sakai, H., Miyata, T., Nakajima, K. and Gotoh, Y.

PNAS Vol. 113 page： E2955-64 2016.5

Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells. Reviewed

Okamoto, M., Miyata, T., Konno, D., Ueda, H. R., Kasukawa, T., Hashimoto, M., Matsuzaki, F., Kawaguchi, A.

Nat Commun. Vol. 7 page： 11349 2016.4

Synergistic action of nectins and cadherins generates the mosaic cellular pattern of the olfactory epithelium. Reviewed

Katsunuma, S., Honda, H., Shinoda, T., Ishimoto, Y., Miyata, T., Kiyonari, H., Abe, T., Nibu, K., Takai, Y., Togashi, H.

J. Cell. Biol. Vol. 212 page： 561-575 2016.2

Consensus paper: Cerebellar development. Reviewed

Leto, K., Arancillo, M., Becker, E. B. E., Buffo, A., Chiang, C., Ding, B., Dobyns, W. B., Dusart, I., Haldipur, P., Hatten, M. E., Hoshino, M., Joyner, A. L., Kano, M., Kilpatrick, D. L., Koibuchi, N., Marion, S., Martinez, S., Millen, K. J., Millner, T. O., Miyata, T., Parmigiani, E., Schilling, K., Sekerkova, G., Sillitoe, R. V., Sotelo, C., Uesaka, N., Wefers, A., Wingate, R. J. T., Hawkes, R.

The Cerebellum 2015.10

Language：English Publishing type：Research paper (scientific journal)

he development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main processes of cerebellar ontogenesis, highlighting the neurogenic strategies used by developing progenitors, the genetic programs involved in cell fate specification, the progressive changes of structural organization, and some of the better-known abnormalities associated with developmental disorders of the cerebellum.

DOI： 10.1007/s12311-015-0724-2

Interkinetic nuclear migration generates and opposes ventricular-zone crowding: insights into tissue mechanics Reviewed

Miyata, T., Okamoto, M., Shinoda, T., Kawaguchi, A

Front. Cell. Neurosci. Vol. 8 page： 473 2015.1

神経幹細胞の集団的な核移動

宮田卓樹

脳神経系の再生医学ー発生と再生の融合的新展開ー（診断と治療社再生医療シリーズ） page： 50-54 2015.1

Programmable wireless light-emitting diode stimulator for chronic stimulation of optogenetic molecules in freely moving mice. Reviewed

Hashimoto, M., Hata, A., Miyata, T., Hirase, H.

Programmable wireless light-emitting diode stimulator for chronic stimulation of optogenetic molecules in freely moving mice. Vol. 1 page： 011002 2014.5

Dynamics of centrosome translocation and microtubule organization in neocortical neurons during distinct modes of polarization. Reviewed

Sakakibara, A., Sato, T., Ando, R., Noguchi, N., Masaoka, M., Miyata, T.

Cereb. Cortexdoi:10.1093/cercor/bhs411 2014

Ferret-mouse differences in interkinetic nuclear migration and cellular densification in the neocortical ventricular zone. Reviewed

Okamoto, M., Shinoda, T., Kawaue, T., Nagasaka, A., Miyata, T.

Neurosci. Res. Vol. 83 page： 25-32 2014

Visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain. Reviewed

Kawaue T, Sagou K, Kiyonari H, Ota K, Okamoto M, Shinoda T, Kawaguchi A, Miyata T.

Dev Growth Differ Vol. 56 page： 293-304 2014

Pioneering axons regulate neuronal polarization in the devveloping cerebral cortex. Reviewed

Namba, T., Kibe, Y., Funahashi, Y., Nakamuta, S., Takano, T., Ueno, T., Shimada, A., Kozawa, S., Okamoto, M., Shimoda, Y., Oda, K., Wada, Y., Masuda, T., Sakakibara, A., Igarashi, M., Miyata, T., Faivre-Sarrailh, C., Takeuchi, K., Kaibuchi, K.

Neuron Vol. 81 page： 814-829 2014

脳形成を下支えする神経前駆細胞の核移動

宮田卓樹，岡本麻友美

生体の科学（特集「器官の発生と再生の基礎」） Vol. 65 page： 203-207 2014

Overview （特集「動く細胞・群れる細胞」）

宮田卓樹

細胞工学 ( 33 ) page： 590-592 2014

神経前駆細胞の空間的安寧を支えるヘテロ物流

岡本麻友美，篠田友靖，宮田卓樹

細胞工学 ( 33 ) page： 645-649 2014

Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: Visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain Reviewed

Kawaue T, Sagou K, Kiyonari H, Ota K, Okamoto M, Shinoda T, Kawaguchi A, Miyata T.

Dev Growth Differ. page： 293-304 2014

Septins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation. Reviewed

Ageta-Ishihara, N., Miyata, T., Ohshima, C., Watanabe, M., Sato, Y., Hamamura, Y., Higashijima, T., Mazitschek, R., Bito, H., Kinoshita, M.

Nature Communications Vol. 4 page： 2532 2013.10

Improved orange and red Ca2+ indicators and photophysical considerations for optogenetic applications. Reviewed

Wu, J , Liu, L , Matsuda, T , Zao, Y, Rebane, A , Drobizhev, M , Chang, Y-F , Araki, S , Arai, Y , March, K , Thomas, HE, Sagou, K , Miyata, T, Nagai, T , Li, W-H , and Campbell, RE

ACS Chem. Neurosci. 2013.3

Shootin1 acts in concert with KIF20B to promote polarization of migrating neurons. Reviewed

Sapir, T., Levy, T., Sakakibara, A., Rabinkov, A., Miyata, T., Reiner, O.

J. Neurosci. Vol. 33 page： 11932-11948 2013

Reelin-dependent ApoER2 downregulation uncouples newborn neurons from progenitor cells. Reviewed

Pérez-Martínez, F.J., Luque-Río, A., Sakakibara, A., Hattori, M., Miyata, T., Luque, J. M.

Biology Open 2012.10

WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration. Reviewed

Xie, M.-J., Yagi, H., Kuroda, K., Wang, C.-C., Komada, M., Zhao, H., Sakakibara, A., Miyata, T. Nagata, K., Iguchi, T., Sato, M.

Cereb. Cortex page： doi:10.1093 2012

Local Application of Neurotrophins Specifies Axons Through Inositol 1,4,5-Trisphosphate, Calcium, and Ca2+/Calmodulin-Dependent Protein kinases. Reviewed

Nakamuta S, Funahashi Y, Namba T, Arimura N, Picciotto M R, Tokumitsu H, Soderling T R, Sakakibara A, Miyata T, Kamiguchi H, and Kaibuchi K.

Science Signaling Vol. 4 2011.11

小脳皮質形成メカニズムの解明をめざして：プルキンエ細胞の移動と配置の過程に関する新知見 Invited

宮田卓樹

ブレインサイエンスレビュー Vol. 2011 page： 91-110 2011

T. Girdin maintains the stemness of glioblastoma stem cells. Reviewed

Natsume, S., Kato, T., Kinjo, S., Enomoto, A., Toda, H., Shimato, S., Ohka F, Motomura K, Kondo Y, Miyata T, Takahashi M, Wakabayashi T.

Oncogene ( 31 ) page： 2715-2724 2011

Mechanisms that regulates the number of neurons during mouse neocortical development Reviewed

Takaki Miyata, Daichi Kawaguchi, Ayano Kawaguchi, Yukiko Gotoh

Current Opinion in Neurobiology Vol. 20 page： 1-7 2010

Periventricular Notch activation and asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cells Reviewed

Ochiai, W., Nakatani, S., Takahara, T., Kainuma, M., Masaoka, M., Minobe, S., Namihira, M., Nakashima, K., Sakakibara, A., Ogawa, M., Miyata, T

Mol. Cell. Neurosci. Vol. 40 page： 225-233 2009

Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stages. Reviewed

Uchida T, Baba A, Pérez-Martínez FJ, Hibi T, Miyata T, Luque JM, Nakajima K, Hattori M.

J Neurosci. Vol. 29 page： 10653-10662 2009

Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Reviewed

Saito K, Dubreuil V, Arai Y, Wilsch-Bräuninger M, Schwudke D, Saher G, Miyata T, Breier G, Thiele C, Shevchenko A, Nave KA, Huttner WB.

Proc Natl Acad Sci U S A. Vol. 106 page： 8350-8355 2009

Rac is involved in the interkinetic nuclear migration of cortical progenitor cells. Reviewed

Minobe, S., Sakakibara, A., Ohdachi, T., Kanda, R., Kimura, M., Nakatani, S., Tadokoro, R., Ochiai, W., Nishizawa, Y., Mizoguchi, A., Kawauchi, T., Miyata, T.

Neurosci. Res. Vol. 63 page： 294-301 2009

Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis. Reviewed

Konno, D., Shioi, G., Shitamukai, A., Mori, A., Kiyonari, H., Miyata, T. and Matsuzaki, F

Nat. Cell Biol. Vol. 10 page： 93-101 2008

Mind bomb 1-experssing intermediate progenitors generate Notch signaling to maintain radial glial cells. Reviewed

Yoon, K.-J., Koo, B.-K., Jeong, H.-W., Ghim, J., Kwon, M.-C., Moon, J.-S., Miyata, T., Kong, Y.-Y.

Neuron Vol. 58 page： 519-531 2008

大脳皮質における層形成 Invited

宮田卓樹

実験医学 Vol. 26 page： 1875-1879 2008

Cell-cycle-specific nestin expression coordinates with morphological changes in embryonic cortical neural progenitors Reviewed

Sunabori, T., Tokunaga, A., Nagai, T., Sawamoto, K., Okabe, M., Miyawaki, A., Matsuzaki, Y., Miyata, T., Okano, H.

J. Cell Sci. Vol. 121 page： 1204-1212 2008

Development of three-dimensional srchitecture of the neuroepithelium: Role of pseudostratification and cellular 'community' Reviewed

Takaki Miyata

Dev. Growth Differ. Vol. 50 page： S105-S112 2008

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression Reviewed

Sakaue-Sawano, A., Kurokawa, H., Morimura, T., Hanyu, A., Hama, H., Osawa, H., Kashiwagi, S., Fukami, K., Miyata, T., Miyoshi, H., Imamura, T., Ogawa, M., Masai, H. and Miyawaki, A.

Cell Vol. 132 page： 487-498 2008

Photopic electroretinograms of mGluR6-deficient mice.

Koyasu T, Kondo M, Miyata K, Ueno S, Miyata T, Nishizawa Y, Terasaki H

Curr Eye Res. Vol. 33 page： 91-99 2008

Pax6 transcription factor regulates interkinetic nuclear movement in cortical progenitor cells via centrosomal stabilization Reviewed

Tamai, H., Shinohara, H., Miyata, T., Saito, K., Nishizawa, Y., Nomura, T. and Osumi, N

Genes to Cells Vol. 12 page： 983-996 2007.9

Morphology and mechanics of daughter cells "delaminating" from the ventricular zone of the developing neocortex Reviewed

Takaki Miyata

Cell Adhesion & Migration Vol. 1 ( 2 ) page： 99-101 2007.4

大脳皮質原基におけるニューロンの誕生と旅立ち Invited

宮田卓樹

実験医学 Vol. 25 ( 3 ) page： 333-337 2007.2

Transformation of pin-like ventricular zone cells into cortical neurons. Reviewed

Ochiai, W., Minobe, S., Ogawa, M., Miyata, T.

Neurosci. Res. Vol. 57 page： 326-329 2007

Survey of the morphogenetic dynamics of the ventricular surface of the developing mouse cortex Reviewed

Nishizawa, Y., Imafuku, H., Saito, K., Kanda, R., Kimura, M., Minobe, S., Miyazaki, F., Kawakatsu, S., Masaoka, M., Ogawa, M. and Miyata, T

Dev. Dyn. Vol. 236 page： 3061-3070 2007

大脳皮質形成過程における細胞動態の３次元ライブ観察 Invited Reviewed

宮田卓樹

顕微鏡 Vol. 42 page： 174-179 2007

Twisting of neocortical progenitor cells underlies a spring-like mechanism for daughter cell migration. Reviewed

Miyata, T., Ogawa, M.

Curr. Biol. Vol. 17 page： 146-151 2007

Midkine, a heparin-binding growth factor, is expressed in neural precursor cells and promotes their growth. Reviewed

Zou, P., Muramatsu, H., Miyata, T., and Muramatsu, T

J. Neurochem Vol. 99 page： 1470-1479 2006

The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. Reviewed

Hirai, S., Cui, DF., Miyata, T., Ogawa, M., Kiyonari, H., Suda, Y., Aizawa, S., Banda, Y. and Ohno, S

J Neurosci Vol. 26 page： 11992-12002 2006

移動ニューロンの骨格と接着：神経上皮長屋の屋根裏部屋にて Invited

宮田卓樹

蛋白質核酸酵素 Vol. 51 page： 721-726 2006

Inactivation of aPKCλ results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex. Reviewed

Imai, F., Hirai, S., Akimoto, K., Koyama, H., Miyata, T., Ogawa, M., Noguchi, S., Sasaoka, T., Noda, T, and Ohno, S.

Development Vol. 133 page： 1735-1744, 2006

Dynamic behavior of individual cells in developing organotypic brain slices revealed by the photoconvertable protein Kaede. Reviewed

Muto, T.,, Miyata, T., Kashiwagi, S., Miyawaki, A., and Ogawa, M.

Exp. Neurol Vol. 200 page： 430-437 2006

Induction of oligodendrocyte progenitors in dorsal forebrain by intraventricular microinjection of FGF-2. Reviewed

Naruse, M., Nakahira, E., Miyata, T., Hitoshi, S., Ikenaka, K., and Bansai, R

Dev. Biol Vol. 297 page： 262-273 2006

Modern slice culture for direct observation of production and migration of brain neurons Reviewed

Miyata T, Saito K, Nishizawa Y, Murayama A, Masaoka M, Ogawa M.

Nagoya J Med Sci Vol. 67 page： 65-70 2005

神経上皮における細胞周期，運命決定，組織形成運動のリンク Invited

宮田卓樹

実験医学 Vol. 23 page： 1480-1485 2005

スライス培養により読み解く中枢神経系の組織形成機構 Invited

宮田卓樹

日本神経精神薬理雑誌 Vol. 25 page： 175-181 2005

「脳室下帯」における皮質ニューロン産生 Invited

宮田卓樹

脳２１ Vol. 8 page： 245-250 2005

Physiological function of S-cone system is not enhanced in rd7 mice. Reviewed

Ueno S, Kondo M, Miyata K, Hirai T, Miyata T, Usukura J, Nishizawa Y, Miyake Y.

Exp Eye Res. ( 81 ) page： 751-758 2005

Both type-I hemidesmosomes and adherens-type junctions contribute to the cell-substratum adhesion system in myoepithelial cells. Reviewed

Uematsu J, Nishizawa Y, Hirako Y, Kitamura K, Usukura J, Miyata T, Owaribe K.

Eur J Cell Biol. ( 84 ) page： 407-415 2005

Differential expression of Pax6 and Ngn2 between pair-generated cortical neurons. Reviewed

Kawaguchi, A., Ogawa, M., Saito, K., Matsuzaki, F., Okano, H., and Miyata, T.

J. Neurosci. Res. Vol. 78 page： 784-795 2004

Morphological asymmetry in dividing retinal progenitor cells. Reviewed

Saito, K., Kawaguchi, A., Kashiwagi, S., Yasugi, S., Ogawa, M., and Miyata, T.

Develop. Growth & Differ. Vol. 45 page： 219-229 2003

小脳の縦縞状区画化と皮質形成：Purkinje細胞の誕生・移動・配置の分子機構 Invited

橋本光広，宮田卓樹

脳の科学 Vol. 25 page： 543-549 2003

Visualization of cell cycling by an improvement in slice culture methods. Reviewed

Miyata, T., Kawaguchi, A., Saito, K., Kuramochi, H., and Ogawa, M.

J. Neurosci. Res. Vol. 69 page： 861-868 2002

Transplantation of in vitro-expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. Reviewed

Ogawa Y, Sawamoto K, Miyata,T., Miyao S, Watanabe M, Nakamura M, Bregman BS, Koike M, Uchiyama Y, Toyama Y, Okano H.

J. Neurosci. Res. Vol. 69 page： 925-933 2002

Increased proliferation of neural progenitor cells but reduced survival of newborn cells in the contralateral hippocampus after focal cerebral ischemia in rats. Reviewed

Takasawa K, Kitagawa K, Yagita Y, Sasaki T, Tanaka S, Matsushita K, Ohstuki T, Miyata T, Okano H, Hori M, Matsumoto M.

J. Cereb. Blood Flow Metab. Vol. 22 page： 299-307 2002

Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia. Reviewed

Yagita Y, Kitagawa K, Sasaki T, Miyata, T., Okano H, Hori M, Matsumoto M. Differential

J. Neurosci. Res. Vol. 69 page： 750-756 2002

Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex. Reviewed

Shinozaki, K., Miyagi, T., Yoshida, M., Miyata, T., Ogawa, M., Aizawa, S., and Suda, Y.

Development Vol. 129 page： 3479-3492 2002

胎生期大脳組織の三次元培養：複雑さへの回帰 Invited

宮田卓樹，齋藤加奈子，川口綾乃，小川正晴

生体の科学 Vol. 53 page： 243-249 2002

Proliferation of neuronal progenitor cells and increased neurogenesis in the ischemic adult rat hippocampus. Reviewed

Yagita, Y., Kitagawa, K., Otsuki, T., Kuwabara, K., Mabuchi, T., Miyata, T., Okano, H., Hori, M., and Matsumoto, M.:

Stroke Vol. 32 page： 1890-1896 2001

Assessment of the developmental totipotency of neural cells in the cerebral cortex of mouse embryo by nuclear transfer. Reviewed

Yamazaki, Y., Makino, H., Hamaguchi-Hamada, K., Hamada, S., Sugino, H., Kawase, E., Miyata, T., Ogawa, M., Yanagimachi. R., and Yagi, T.

Proc. Natl. Acad. Sci. USA Vol. 98 page： 14022-14026 2001

Nestin-EGFP mice: visualization of the self-renewal and multipotency of CNS stem cells. Reviewed

Kawaguchi, A., Miyata, T., Sawamoto, K., Takashita, N., Murayama, A., Akamatsu, W., Ogawa, M., Okabe, M., Tano, Y., Goldman, S.A., and Okano, H.

Mol. Cell. Neurosci. Vol. 17 page： 259-273 2001

DiI を用いた脳原基スライス培養ー神経上皮ジャングル探検の愉しみー Invited

宮田卓樹

細胞工学 Vol. 20 page： 1410-1419 2001

大脳皮質におけるニューロンの産生と配置の機構 Invited

宮田卓樹，小川正晴

医学のあゆみ Vol. 199 page： 1000-1004 2001

発達脳における神経細胞の移動：　新しいニューロン移動法とその原理 Invited

宮田卓樹，川口綾乃，岡野栄之，小川正晴

生体の科学 Vol. 52 page： 224-229 2001

Musashi1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells. Reviewed

Kaneko, Y., Sakakibara, S., Imai, T., Suzuki, A., Nakamura, Y., Sawamoto, K., Ogawa, Y., Toyama, Y., Miyata, T., and Okano, H.

Dev. Neurosci. Vol. 22 page： 139-153 2000

The bHLH gene Hes1 as a repressor of neuronal commitment of the CNS stem cells. Reviewed

Nakamura, Y., Sakakibara, S., Miyata, T., Ogawa, M., Shimazaki, T., Weiss, S., Kageyama, R., and Okano, H.

J. Neurosci. Vol. 20 page： 283-293 2000

Dissection of signaling cascade through gp130 in vivo: Reciprocal roles for STAT3-and SHP2-mediated signals in cytokine and immunoglobulin production. Reviewed

Ohtani, T., Ishihara, K., Atsumi, T., Nishida, K., Keneko, Y., Miyata, T., Itoh, S., Narimatsu, M., Maeda, H., Fukada, T., Itoh, M., Okano, H., Hibi, T., and Hirano, T.

Immunity Vol. 12 page： 95-105 2000

小脳の発生に関する分子機構：プルキンエ細胞と顆粒神経細胞の大河ドラマ Invited

宮田卓樹，小川正晴

神経研究の進歩 Vol. 44 page： 965-973 2000

Distinct arrangement patterns of Purkinje cells between normal and reeler mice are reproduced in cerebellar explants. Reviewed

Miyata, T., Nakajima, K., Mikoshiba, K., and Ogawa, M.

Dev. Neurosci. Vol. 19 page： 124 1997

A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/Reelin. Reviewed

Yoneshima, H., Nagata, E., Matsumoto, M., Yamada, M., Nakajima, K., Miyata, T., Ogawa, M., and Mikoshiba, K.

Neurosci. Res. Vol. 29 page： 217-223 1997

大脳・小脳における層形成機構ー「皮質ニューロン号」の離着陸 Invited

宮田卓樹，仲嶋一範，御子柴克彦，小川正晴

実験医学 Vol. 15 page： 1600-1606 1997

A role for Cajal-Retzius cells and reelin in the development of hippocampal connections. Reviewed

Del Rio, J., Heimrich, B., Borrell, V., Froster, E., Drakew, A., Alcantara, S., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., Derer, P., Frotscher, M., and Soriano, E.:

Nature Vol. 385 page： 70-74 1997

Disruption of hippocampal development in vivo by CR-50 mAb against Reelin. Reviewed

Nakajima, K., Mikoshiba, K., Miyata, T., Kudo, C., and Ogawa, M.

Proc. Natl. Acad. Sci. USA Vol. 94 page： 8196-8201 1997

A truncated Reelin protein is produced but not secreted in the 'Orleans' reeler mutation. Reviewed

De Vergeyck, V., Nakajima, K., Lambert de Rouvroit, C., Naerhuyzen, B., Goffinet, A. M., Miyata, T., Ogawa, M., and Mikoshiba, K.

Mol. Brain Res. Vol. 50 page： 85-90 1997

Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody. Reviewed

D'Arcangelo, G., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., Curran, T.

J. Neurosci. Vol. 17 page： 23-31 1997

Mouse-musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell. Reviewed

Sakakibara, S., Okano, H., Imai, T., Hamaguchi, K., Aruga, J., Nakajima, K., Nagata, T., Kurihara, Y., Uesugi, S., Miyata, T., Ogawa, M., and Mikoshiba, K.

Dev. Biol. Vol. 176 page： 230-242 1996

Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice. Reviewed

Miyata, T., Nakajima, K., Aruga, J., Takahashi, S., Ikenaka, K., Mikoshiba, K, and Ogawa, M.

J Comp. Neurol. Vol. 372 page： 215-228 1996

The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons. Reviewed

Ogawa, M., Miyata, T., Nakajima, K., Yagyu, K., Ikenaka, K., Yamamoto, H., and Mikoshiba, K.

Neuron Vol. 14 page： 899-912 1995

Identification of two highly homologous presynaptic proteins distinctly localized at the dendritic and somatic synapses. Reviewed

Takahashi, S., Yamamoto, H., Matsuda, Z., Ogawa, M., Yagyu, K., Taniguchi, T., Miyata, T., Koda, H., Higuchi, T., Okutani, F., and Fujimoto, S.

FEBS letters Vol. 368 page： 455-460 1995

Developmental potentials of early telencephalic neuroepithelial cells: a study with microexplant culture. Reviewed

Miyata, T., and Ogawa, M.

Dev. Growth & Differ. Vol. 36 page： 319-331 1994

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