研究者詳細 - 田中　健太郎

論文 - 田中　健太郎

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Artificial metallo-DNA: Structural control of DNA and nano-assembly of metal complexes

Kentaro Tanaka, Mitsuhiko Shionoya

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 62 巻頁： 508-513 2004年1月

掲載種別：研究論文（学術雑誌）

DNA has a structural basis for the "bottom-up" fabrication of functionalized molecular building blocks. In particular, the replacement of hydrogen-bonded DNA base pairing for alternative one would lead to a novel tool for re-engineering DNA. Recently, we have synthesized a series of artificial nucleosides bearing metal ligands instead of natural nucleobases and demonstrated that metal complexation between the nucleosides effectively drives base pairing. This review describes our recent approaches to metal-based strategy directed towards self-assembled metal arrays within DNA as well as towards structural control of DNA. This strategy provides a new method for self-assembled metal arrays in a predesigned fashioji, leading possibly to metal-based molecular devices such as molecular magnets and wires.

DOI： 10.5059/yukigoseikyokaishi.62.508

Scopus

金属錯体型人工ＤＮＡ招待有り

塩谷光彦, 田中健太郎

蛋白質核酸酵素 49 巻頁： 1438-1443 2004年

金属錯体型人工ＤＮＡ：ＤＮＡ構造制御と金属錯体ナノ集積化招待有り

田中健太郎, 塩谷光彦

有機合成化学協会誌 8 巻頁： 592-579 2004年

Interaction of plastocyanin with oligopeptides: effect of lysine distribution within the peptide 査読有り

Shun Hirota, Hisano Okumura, Sachiko Arie, Kentaro Tanaka, Mitsuhiko Shionoya, Teruhiro Takabe, Noriaki Funasaki, amd Yoshihito Watanabe

Journal of Inorganic Biochemistry 98 巻頁： 849-855 2004年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

We synthesized and purified four oligopeptides containing four lysines (KKKK, GKKGGKK, KKGGGKK, and KGKGKGK) as models for the plastocyanin (PC) interacting site of cytochrome f. These peptides competitively inhibited electron transfer between cytochrome c and PC. The inhibitory effect increased as the peptide concentrations were increased. The association constants between PC and the peptides did not differ significantly (3500-5100 M

Artificial Metallo-DNA: A Bio-Inspired Approach to Metal Array Programming 招待有り査読有り

M. Shionoya and K. Tanaka

Curr. Opin. Chem. Biol. 8 巻頁： 592-579 2004年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

The structure of DNA is such that the multi-array of functionalized units with desired numbers and sequences within the DNA is possible. In particular, to replace DNA bases, which are biologically important elements for gene expression, by alternative bases would provide powerful tools for programming molecular arrays in a pre-designed manner. This review focuses on recent chemical approaches to
self-assembled metal arrays within DNA with metal-mediated base pairing.

Role of a non-natural beta-C-nucleotide unit in DNA as a template for DNA and RNA syntheses and as a substrate for nucleolytic digestion. 査読有り

Aketani S, Tanaka K, Yamamoto K, Ishihama A, Cao H, Tengeiji A, Shionoya M

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20 巻 ( 1 ) 頁： 43-51 2003年9月

A discrete self-assembled metal array in artificial DNA. 査読有り

Tanaka K, Tengeiji A, Kato T, Toyama N, Shionoya M

Science (New York, N.Y.) 299 巻 ( 5610 ) 頁： 1212-1213 2003年2月

Artificial nucleosides possessing metal binding sites at the 3'- and 5'-positions of the deoxyribose moieties. 査読有り

Chiba JY, Tanaka K, Ohshiro Y, Miyake R, Hiraoka S, Shiro M, Shionoya M

The Journal of organic chemistry 68 巻 ( 2 ) 頁： 331-338 2003年1月

Artificial Nucleosides Possessing Metal Binding Sites at the 3'- and 5'-Positions of the Deoxyribose Moieties 査読有り

J. Chiba, K. Tanaka, Y. Ohshiro, R. Miyake, M. Shiro, and M. Shionoya

J. Org. Chem. 68 巻頁： 331-338 2003年

Role of a Non-natural β-C-Nucleotide Unit in DNA as a Template for DNA and RNA Syntheses and as a Substrate for Nucleolytic Digestion 査読有り

S. Aketani, K. Tanaka, K. Yamamoto, A. Ishihama, H. Cao, A. Tengeiji, and M. Shionoya

Eur. J. Pharm. Sci. 20 巻頁： 43-51 2003年

Artificial Metallo-DNA: Structural Control and Discrete Metal Assembly 査読有り

K. Tanaka, Y. Yamada, A. Tengeiji, T. Kato, N. Toyama, Y. Takezawa, M. Yori, M. Shiro, and M. Shionoya

Nucleic Acids Research Supplement 3 巻頁： 121-122 2003年

Artificial metallo-DNA: structural control and discrete metal assembly. 査読有り

Tanaka K, Yamada Y, Tengeiji A, Kato T, Toyama N, Takezawa Y, Yori M, Shiro M, Shionoya M

Nucleic acids research. Supplement (2001) ( 3 ) 頁： 121-122 2003年

Syntheses and structure-activity relationships of nonnatural beta-C-nucleoside 5'-triphosphates bearing an aromatic nucleobase with phenolic hydroxy groups: inhibitory activities against DNA polymerases. 査読有り

Aketani S, Tanaka K, Yamamoto K, Ishihama A, Cao H, Tengeiji A, Hiraoka S, Shiro M, Shionoya M

Journal of medicinal chemistry 45 巻 ( 25 ) 頁： 5594-5603 2002年12月

Efficient incorporation of a copper hydroxypyridone base pair in DNA. 査読有り

Tanaka K, Tengeiji A, Kato T, Toyama N, Shiro M, Shionoya M

Journal of the American Chemical Society 124 巻 ( 42 ) 頁： 12494-12498 2002年10月

Formation of silver(I)-mediated DNA duplex and triplex through an alternative base pair of pyridine nucleobases. 査読有り

Tanaka K, Yamada Y, Shionoya M

Journal of the American Chemical Society 124 巻 ( 30 ) 頁： 8802-8803 2002年7月

Syntheses of nucleic acid mimics designed for metal-induced strand formation on DNA

Akihiko Hatano, Kentaro Tanaka, Motoo Shiro, Mitsuhiko Shionoya

Tetrahedron 58 巻頁： 2965-2972 2002年4月

掲載種別：研究論文（学術雑誌）

This paper describes design and syntheses of a new class of chelator-type nucleic acid mimics. Four nucleic acid mimics 7, 11, 15, 17 possess a nucleobase and two ethylenediamine moieties for intermolecular metal coordination. We expected that chelator-type nucleic acid mimics formed a strand in the presence of metal ion and then interacted with a single-stranded DNA. Efficient synthetic routes leading to the four nucleic acid analogues have been achieved via the key intermediate compound 5 which was derived from 3,5-dimethylphenol in five steps. Compound 7 was treated with zinc nitrate and Zn complex 8 was isolated as crystals.1H NMR study of Zn complex 8 in D2O showed the single-strand formation. Job plots showed that mixture of (dT)70with Zn complex 8 at 5°C reached a minimum absorbance at a mole ratio of 2:1, and the hypochromic effect showed the π-π stacking interaction between the nucleobases. Thermal denaturation study at 2:1 mole ratio of complexes between (dT)70and Zn complex 8 showed melting point at 27°C. © 2002 Elsevier Science Ltd. All rights reserved.

DOI： 10.1016/S0040-4020(02)00203-X

Scopus

Toward nano-assembly of metals through engineered DNAs

Kentaro Tanaka, Motoyuki Tasaka, Honghua Cao, Mitsuhiko Shionoya

Supramolecular Chemistry 14 巻頁： 255-261 2002年1月

Towards Nano-Assembly of Metals with Engineered DNAs 査読有り

K. Tanaka, M. Tasaka, H. Cao, and M. Shionoya

Supramol. Chem. 14 巻頁： 255-261 2002年

Syntheses of Nucleic Acid Mimics Designed for Metal-Induced Strand Formation on DNA 査読有り

A. Hatano, K. Tanaka, M. Shiro and M. Shionoya

Tetrahedron 58 巻頁： 2965-2972 2002年

Synthesis and Structure-Activity Relationships of Nonnatural β-C-Nucleoside Triphosphates Bearing an Aromatic Nucleobase with Phenolic Hydroxyl Groups: Inhibitory Activities against DNA Polymerases 査読有り

S. Aketani, K. Tanaka, K. Yamamoto, A. Ishihama, H. Cao, A. Tengeiji, S. Hiraoka, M. Shiro, and M. Shionoya

J. Med. Chem. 25 巻頁： 5594-5603 2002年

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