2025/03/13 更新

写真a

ミサワ トモコ
三澤 知子
MISAWA Tomoko
所属
医学部附属病院 麻酔科 病院助教
職名
病院助教

学位 1

  1. 学士(医学) ( 2014年3月   三重大学 ) 

 

論文 1

  1. Elevated level of urinary tellurium is a potential risk for increase of blood pressure in humans and mice Open Access

    Misawa, T; Kagawa, T; Ohgami, N; Tazaki, A; Ohnuma, S; Naito, H; Chen, DJ; Gu, YS; Tamura, T; Wakai, K; Nishiwaki, K; Kato, M

    ENVIRONMENT INTERNATIONAL   188 巻   頁: 108735   2024年6月

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    記述言語:英語   出版者・発行元:Environment International  

    Background: People worldwide are routinely exposed to tellurium mainly via dietary ingestion. There has been no study to clarify the contribution of tellurium to blood pressure in humans or animals. Methods: In this cross-sectional study conducted in a general population of 2592 residents in Japan, the associations of urinary tellurium levels with blood pressure and prevalence of hypertension were investigated. The potential sources of tellurium were also investigated. An interventional study in mice confirmed the effect of tellurium exposure on blood pressure. Results: Linear and logistic regression analyses with consideration of confounders including urinary sodium–potassium ratio showed significant positive associations of urinary tellurium level with prevalence of hypertension and blood pressure. Cereals/beans and vegetables/fruits were determined to be potential dietary sources of tellurium exposure. Intermediary analysis suggested that increased intake of cereals/beans, but not that of vegetables/fruits, is positively associated with the tellurium-mediated risk of hypertension. Correspondingly, the mouse study showed that exposure to a putative human-equivalent dose of tellurium via drinking water increased blood pressure with an elevated level of urinary tellurium. The temporally increased blood pressure was decreased to the normal level by a break of tellurium exposure with a reduced level of urinary tellurium. Conclusions: The interdisciplinary approach provided the first evidence that tellurium exposure is a potential risk for increase of blood pressure. Since the human urinary tellurium level in this study is comparable with the levels in general populations in other Asian and European countries in previous studies, exposure to tellurium may be a latent universal risk for hypertension.

    DOI: 10.1016/j.envint.2024.108735

    Open Access

    Web of Science

    Scopus

    PubMed

科研費 1

  1. 認知予備力とミトコンドリア機能の脆弱性との関連を探る

    研究課題/研究課題番号:20K09240  2020年4月 - 2023年3月

    三澤 知子

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    担当区分:研究代表者 

    配分額:4030000円 ( 直接経費:3100000円 、 間接経費:930000円 )

    「認知予備力」が低下しているといわれる高齢患者が好発する術後せん妄(POD)や術後高次脳機能障害(POCD)の病因・病態生理は未だ不明な点が多い。我々は、抗POD/POCD薬創出を目指す上で、「認知予備力の大小は、認知機能に関与する神経細胞が細胞障害性刺激を受けた際のミトコンドリア機能の脆弱性の度合いである」という仮説をたてた。本研究では、老化促進モデルマウスの様々な老化ポイントにおいて、POD様症状発現誘発処置後の行動変化発現の有無を観察し、大脳皮質や海馬を摘出する。組織からグルタミン酸神経やアセチルコリン神経のシナプトソーム画分を特異的に単離し、ミトコンドリア機能を解析する。