研究者詳細 - 愛場　雄一郎

論文 - 愛場　雄一郎

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Catalytic Oxidation of Methane by Wild-Type Cytochrome P450BM3 with Chemically Evolved Decoy Molecules 査読有り国際誌

Ariyasu, S; Yonemura, K; Kasai, C; Aiba, Y; Onoda, H; Shisaka, Y; Sugimoto, H; Tosha, T; Kubo, M; Kamachi, T; Yoshizawa, K; Shoji, O

ACS CATALYSIS 13 巻 ( 13 ) 頁： 8613 - 8623 2023年6月

A Compound I Mimic Reveals the Transient Active Species of a Cytochrome P450 Enzyme: Insight into the Stereoselectivity of P450-Catalysed Oxidations 査読有り国際誌

Suzuki, K; Stanfield, JK; Omura, K; Shisaka, Y; Ariyasu, S; Kasai, C; Aiba, Y; Sugimoto, H; Shoji, O

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 62 巻 ( 13 ) 頁： e202215706 2023年3月

Biological and Medicinal Chemistry Search within Biological and Medicinal Chemistry Sequence-Specific Recognition of Double-Stranded DNA by Using Only PNAs in Parallel with Natural Nucleobases 国際誌

Masanari Shibata,Yuichiro Aiba, Masaki Hibino,Osami Shoji

ChemRxiv 2022年9月

A P450 Harboring Manganese Protoporphyrin IX Generates a Manganese Analogue of Compound I by Activating Dioxygen 査読有り国際誌

Omura, K; Aiba, Y; Suzuki, K; Ariyasu, S; Sugimoto, H; Shoji, O

ACS CATALYSIS 12 巻 ( 18 ) 頁： 11108 - 11117 2022年8月

Sequence-Specific Recognition of Double-Stranded DNA by Peptide Nucleic Acid Forming Double-Duplex Invasion Complex 査読有り国際誌

Aiba, Y; Shibata, M; Shoji, O

APPLIED SCIENCES-BASEL 12 巻 ( 7 ) 頁： 3667 2022年4月

C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers 査読有り国際誌

Nanaura, H; Kawamukai, H; Fujiwara, A; Uehara, T; Aiba, Y; Nakanishi, M; Shiota, T; Hibino, M; Wiriyasermkul, P; Kikuchi, S; Nagata, R; Matsubayashi, M; Shinkai, Y; Niwa, T; Mannen, T; Morikawa, N; Iguchi, N; Kiriyama, T; Morishima, K; Inoue, R; Sugiyama, M; Oda, T; Kodera, N; Toma-Fukai, S; Sato, M; Taguchi, H; Nagamori, S; Shoji, O; Ishimori, K; Matsumura, H; Sugie, K; Saio, T; Yoshizawa, T; Mori, E

NATURE COMMUNICATIONS 12 巻 ( 1 ) 頁： 5301 2021年9月

Investigation of the Characteristics of NLS-PNA: Influence of NLS Location on Invasion Efficiency 査読有り国際誌

Aiba, Y; Urbina, G; Shibata, M; Shoji, O

APPLIED SCIENCES-BASEL 10 巻 ( 23 ) 頁： 8663 2020年12月

Cationic guanine: positively charged nucleobase with improved DNA affinity inhibits self-duplex formation 査読有り国際誌

Hibino, M; Aiba, Y; Shoji, O

CHEMICAL COMMUNICATIONS 56 巻 ( 17 ) 頁： 2546 - 2549 2020年2月

Peptide Nucleic Acid Conjugated with Ruthenium-Complex Stabilizing Double-Duplex Invasion Complex Even under Physiological Conditions 査読有り国際誌

Hibino, M; Aiba, Y; Watanabe, Y; Shoji, O

CHEMBIOCHEM 19 巻 ( 15 ) 頁： 1601 - 1604 2018年8月

Reconstitution of full-length P450BM3 with an artificial metal complex by utilising the transpeptidase Sortase A 査読有り国際誌

Omura, K; Aiba, Y; Onoda, H; Stanfield, JK; Ariyasu, S; Sugimoto, H; Shiro, Y; Shoji, O; Watanabe, Y

CHEMICAL COMMUNICATIONS 54 巻 ( 57 ) 頁： 7892 - 7895 2018年7月

Heme-substituted protein assembly bridged by synthetic porphyrin: achieving controlled configuration while maintaining rotational freedom. 査読有り国際誌

Inaba H, Shisaka Y, Ariyasu S, Sakakibara E, Ueda G, Aiba Y, Shimizu N, Sugimoto H, Shoji O

RSC advances 14 巻 ( 13 ) 頁： 8829 - 8836 2024年3月

Highly selective hydroxylation of gaseous alkanes at the terminal position by wild-type CYP153A33 査読有り国際誌

Kodama, Y; Ariyasu, S; Karasawa, M; Aiba, Y; Shoji, O

CATALYSIS SCIENCE & TECHNOLOGY 13 巻 ( 21 ) 頁： 6146 - 6152 2023年10月

Expanding the applicability of cytochrome P450s and other haemoproteins 査読有り国際誌

Ariyasu, S; Stanfield, JK; Aiba, Y; Shoji, O

CURRENT OPINION IN CHEMICAL BIOLOGY 59 巻頁： 155 - 163 2020年12月

Systematic Evolution of Decoy Molecules for the Highly Efficient Hydroxylation of Benzene and Small Alkanes Catalyzed by Wild-Type Cytochrome P450BM3 査読有り国際誌

Yonemura, K; Ariyasu, S; Stanfield, JK; Suzuki, K; Onoda, H; Kasai, C; Sugimoto, H; Aiba, Y; Watanabe, Y; Shoji, O

ACS CATALYSIS 10 巻 ( 16 ) 頁： 9136 - 9144 2020年8月

Molecular Design and Regulation of Metalloenzyme Activities through Two Novel Approaches: Ferritin and P450s 査読有り国際誌

Watanabe, Y; Aiba, Y; Ariyasu, S; Abe, S

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 93 巻 ( 3 ) 頁： 379 - 392 2020年3月

Toxic PR poly-dipeptides encoded by the C9orf72 repeat expansion target Kapβ2 and dysregulate phase separation of low-complexity domains. 国際誌

H. Nanaura, H. Kawamukai, A. Fujiwara, T. Uehara, M. Nakanishi, T. Shiota, M. Hibino, Y. Aiba, P. Wiriyasermkul, S. Kikuchi, R. Nagata, M. Matsubayashi, S. Nagamori, O. Shoji, K. Ishimori, H. Matsumura, K. Sugie, T. Saio, T. Yoshizawa, and E. Mori

bioRxiv 2019年10月

Development of a High-Pressure Reactor Based on Liquid-Flow Pressurisation to Facilitate Enzymatic Hydroxylation of Gaseous Alkanes 査読有り国際誌

Ariyasu, S; Kodama, Y; Kasai, C; Cong, ZQ; Stanfield, JK; Aiba, Y; Watanabe, Y; Shoji, O

CHEMCATCHEM 11 巻 ( 19 ) 頁： 4709 - 4714 2019年10月

Hoodwinking Cytochrome P450BM3 into Hydroxylating Non-Native Substrates by Exploiting Its Substrate Misrecognition 査読有り国際誌

Shoji, O; Aiba, Y; Watanabe, Y

ACCOUNTS OF CHEMICAL RESEARCH 52 巻 ( 4 ) 頁： 925 - 934 2019年4月

Reconstitution of self-sufficient cytochrome P450 with artificial metal complexes 査読有り

Omura, K; Aiba, Y; Ariyasu, S; Shoji, O; Sugimoto, H; Shiro, Y; Watanabe, Y

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 255 巻頁： . 2018年3月

Transfection of PNA-NLS Conjugates into Human Cells Using Partially Complementary Oligonucleotides 査読有り

Aiba, Y; Ohyama, J; Komiyama, M

CHEMISTRY LETTERS 44 巻 ( 11 ) 頁： 1547 - 1549 2015年11月

Promotion of Double-Duplex Invasion of Peptide Nucleic Acids through Conjugation with Nuclear Localization Signal Peptide 査読有り

Aiba, Y; Honda, Y; Komiyama, M

CHEMISTRY-A EUROPEAN JOURNAL 21 巻 ( 10 ) 頁： 4021 - 4026 2015年3月

Exploring the Effect of Sequence Length and Composition on Allele-Selective Inhibition of Human Huntingtin Expression by Single-Stranded Silencing RNAs 査読有り

Hu, JX; Liu, J; Yu, DB; Aiba, Y; Lee, S; Pendergraff, H; Boubaker, J; Artates, JW; Lagier-Tourenne, C; Lima, WF; Swayze, EE; Prakash, TP; Corey, DR

NUCLEIC ACID THERAPEUTICS 24 巻 ( 3 ) 頁： 199 - 209 2014年6月

Allele-Selective Inhibition of Expression of Huntingtin and Ataxin-3 by RNA Duplexes Containing Unlocked Nucleic Acid Substitutions 査読有り

Aiba, Y; Hu, JX; Liu, J; Xiang, Q; Martinez, C; Corey, DR

BIOCHEMISTRY 52 巻 ( 51 ) 頁： 9329 - 9338 2013年12月

ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy 査読有り

Liu, J; Yu, DB; Aiba, Y; Pendergraff, H; Swayze, EE; Lima, WF; Hu, JX; Prakash, TP; Corey, DR

NUCLEIC ACIDS RESEARCH 41 巻 ( 20 ) 頁： 9570 - 9583 2013年11月

Site-selective Scission of Double-stranded DNA by Combining a Triplex-forming bis-PNA and Ce(IV)/EDTA 査読有り

Aiba, Y; Yasuda, K; Komiyama, M

CHEMISTRY LETTERS 42 巻 ( 10 ) 頁： 1300 - 1302 2013年10月

PNA-NLS conjugates as single-molecular activators of target sites in double-stranded DNA for site-selective scission 査読有り国際共著

Aiba, Y; Hamano, Y; Kameshima, W; Araki, Y; Wada, T; Accetta, A; Sforza, S; Corradini, R; Marchelli, R; Komiyama, M

ORGANIC & BIOMOLECULAR CHEMISTRY 11 巻 ( 32 ) 頁： 5233 - 5238 2013年8月

Artificial site-selective DNA cutters to manipulate single-stranded DNA 査読有り

Aiba, Y; Komiyama, M

POLYMER JOURNAL 44 巻 ( 9 ) 頁： 929 - 938 2012年9月

Introduction of multiphosphonate ligand to peptide nucleic acid for metal ion conjugation. 査読有り

Aiba Y, Honda Y, Han Y, Komiyama M

Artificial DNA, PNA & XNA 3 巻 ( 2 ) 頁： 73 - 9 2012年4月

Nanomechanical DNA origami devices as versatile molecular sensors 査読有り

Kuzuya Akinori, Yamazaki Takahiro, Yasuda Kohei, Sakai Yusuke, Yamanaka Yusei, Xu Yan, Aiba Yuichiro, Ohya Yuichi, Komiyama Makoto

IEEE Int. Conf. Nano/Micro Eng. Mol. Syst., 7th 頁： 318-321 2012年

Clear-cut observation of PNA invasion using nanomechanical DNA origami devices 査読有り

Yamazaki, T; Aiba, Y; Yasuda, K; Sakai, Y; Yamanaka, Y; Kuzuya, A; Ohya, Y; Komiyama, M

CHEMICAL COMMUNICATIONS 48 巻 ( 92 ) 頁： 11361 - 11363 2012年

Manipulation of Single-Stranded DNA by Using an Artificial Site-Selective DNA Cutter Composed of Cerium(IV)/EDTA and Phosphonate-Oligonucleotide Conjugates 査読有り国際誌

Aiba, Y; Lönnberg, T; Komiyama, M

CHEMISTRY-AN ASIAN JOURNAL 6 巻 ( 9 ) 頁： 2407 - 2411 2011年9月

Artificial DNA cutters for DNA manipulation and genome engineering 査読有り

Aiba, Y; Sumaoka, J; Komiyama, M

CHEMICAL SOCIETY REVIEWS 40 巻 ( 12 ) 頁： 5657 - 5668 2011年

Oxidation of an Oligonucleotide-Bound Ce<SUP>III</SUP>/Multiphosphonate Complex for Site-Selective DNA Scission 査読有り

Lönnberg, T; Aiba, Y; Hamano, Y; Miyajima, Y; Sumaoka, J; Komiyama, M

CHEMISTRY-A EUROPEAN JOURNAL 16 巻 ( 3 ) 頁： 855 - 859 2010年

Chemical and enzymatic stability of amino acid derived phosphoramidates of antiviral nucleoside 5′-monophosphates bearing a biodegradable protecting group 査読有り

Leisvuori, A; Aiba, Y; Lönnberg, T; Poijärvi-Virta, P; Blatt, L; Beigelman, L; Lönnberg, H

ORGANIC & BIOMOLECULAR CHEMISTRY 8 巻 ( 9 ) 頁： 2131 - 2141 2010年

Handy and prompt DNA separation using PNA with internal disulfide bond. 査読有り国際誌

Aiba Y, Komiyama M

Nucleic acids symposium series (2004) ( 53 ) 頁： 175 - 6 2009年

Introduction of disulfide bond to the main chain of PNA to switch its hybridization and invasion activity 査読有り

Aiba, Y; Komiyama, M

ORGANIC & BIOMOLECULAR CHEMISTRY 7 巻 ( 24 ) 頁： 5078 - 5083 2009年

Introduction of linkers into PNA for versatile applications. 査読有り国際誌

Aiba Y, Komiyama M

Nucleic acids symposium series (2004) ( 52 ) 頁： 143 - 4 2008年

Solid-phase synthesis of pseudo-complementary peptide nucleic acids 査読有り国際誌

Komiyama, M; Aiba, Y; Ishizuka, T; Sumaoka, J

NATURE PROTOCOLS 3 巻 ( 4 ) 頁： 646 - 654 2008年

Artificial restriction DNA cutter for site-selective scission of double-stranded DNA with tunable scission site and specificity 査読有り国際誌

Komiyama, M; Aiba, Y; Yamamoto, Y; Sumaoka, J

NATURE PROTOCOLS 3 巻 ( 4 ) 頁： 655 - 662 2008年

Activation of double-stranded DNA by one pcPNA strand for its site-selective scission with Ce<SUP>IV</SUP>/EDTA 査読有り

Aiba, Y; Yamamoto, Y; Komiyama, M

CHEMISTRY LETTERS 36 巻 ( 6 ) 頁： 780 - 781 2007年6月

Chemical modification of Ce(IV)/EDTA-based artificial restriction DNA cutter for versatile manipulation of double-stranded DNA 査読有り

Yamamoto, Y; Mori, M; Aiba, Y; Tomita, T; Chen, W; Zhou, JM; Uehara, A; Ren, Y; Kitamura, Y; Komiyama, M

NUCLEIC ACIDS RESEARCH 35 巻 ( 7 ) 頁： e53 2007年4月

Highly active artificial restriction enzyme composed of Ce(IV)/EDTA and PNA bearing phosphate group--relationship between the promotion by phosphate and the structure of invasion complex. 査読有り国際誌

Aiba Y, Yamamoto Y, Komiyama M

Nucleic acids symposium series (2004) ( 50 ) 頁： 255 - 6 2006年

Enhancement of RNA cleavage activity of 10-23 DNAzyme by covalently introduced intercalator 査読有り

Asanuma, H; Hayashi, H; Zhao, J; Liang, XG; Yamazawa, A; Kuramochi, T; Matsunaga, D; Aiba, Y; Kashida, H; Komiyama, M

CHEMICAL COMMUNICATIONS ( 48 ) 頁： 5062 - 5064 2006年

Gene manipulation using artificial restriction DNA cutter. 査読有り国際誌

Yamamoto Y, Zhou JM, Tomita T, Uehara A, Aiba Y, Watanabe A, Aburatani H, Komiyama M

Nucleic acids symposium series (2004) ( 49 ) 頁： 73 - 4 2005年

Rapid site-selective hydrolysis of double-stranded DNA by use of Ce(IV)/EDTA and PNA bearing phosphate group. 査読有り国際誌

Aiba Y, Mori M, Yamamoto Y, Komiyama M

Nucleic acids symposium series (2004) ( 49 ) 頁： 277 - 8 2005年

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論文 - 愛場　雄一郎