名古屋大学医学部附属病院   医員

2009.4 - 2010.3

IMAGING FEATURES AND CONSIDERATION OF PROGRESSION PATTERN OF DIFFUSE HEMISPHERIC GLIOMAS, H3 G34-MUTANT

Kibe, Y; Ohka, F; Motomura, K; Aoki, K; Maeda, S; Yamaguchi, J; Shimizu, H; Saito, R

NEURO-ONCOLOGY   Vol. 25   2023.11

GLIOBLASTOMA, IDH-WILDTYPE WITHOUT KEY MOLECULAR FEATURES

Saito, R; Motomura, K; Ohka, F; Yamaguchi, J; Maeda, S; Nishikawa, T; Mizutani, K; Kibe, Y; Shimizu, H; Takido, Y

NEURO-ONCOLOGY   Vol. 25   2023.11

ESTABLISHMENT OF ORGANOID MODELS OF PATIENT-DERIVED GH-PRODUCING PITUITARY ADENOMA

Maeda, S; Ohka, F; Kanamori, F; Okumura, Y; Takeuchi, K; Nagata, Y; Motomura, K; Yamaguchi, J; Kibe, Y; Harada, H; Shimizu, H; Takido, Y; Saito, R

NEURO-ONCOLOGY   Vol. 25   2023.11

Development of machine learning models for predicting unfavorable functional outcomes from preoperative data in patients with chronic subdural hematomas

Fuse, Y; Nagashima, Y; Nishiwaki, H; Ohka, F; Muramatsu, Y; Araki, Y; Nishimura, Y; Ienaga, J; Nagatani, T; Seki, Y; Watanabe, K; Ohno, K; Saito, R

SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page： 16997   2023.10

Predictive factors of post-operative apathy in patients with diffuse frontal gliomas undergoing awake brain mapping

Motomura, K; Kawamura, A; Ohka, F; Aoki, K; Nishikawa, T; Yamaguchi, J; Kibe, Y; Shimizu, H; Maeda, S; Saito, R

JOURNAL OF NEUROPSYCHOLOGY     2023.9

TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation

Suzuki, MM; Iijima, K; Ogami, K; Shinjo, K; Murofushi, Y; Xie, JQ; Wang, XB; Kitano, Y; Mamiya, A; Kibe, Y; Nishimura, T; Ohka, F; Saito, R; Sato, S; Kobayashi, J; Yao, R; Miyata, K; Kataoka, K; Suzuki, HI; Kondo, Y

NATURE COMMUNICATIONS   Vol. 14 ( 1 ) page： 4521   2023.8

Mutation detection of urinary cell-free DNA via catch-and-release isolation on nanowires for liquid biopsy

Takahashi, H; Yasui, T; Hirano, M; Shinjo, K; Miyazaki, Y; Shinoda, W; Hasegawa, T; Natsume, A; Kitano, Y; Ida, M; Zhang, M; Shimada, T; Paisrisarn, P; Zhu, ZT; Ohka, F; Aoki, K; Rahong, S; Nagashima, K; Yanagida, T; Baba, Y

BIOSENSORS & BIOELECTRONICS   Vol. 234   page： 115318   2023.8

Latest classification of ependymoma in the molecular era and advances in its treatment: a review

Yamaguchi, J; Ohka, F; Motomura, K; Saito, R

JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 53 ( 8 ) page： 653 - 663   2023.7

Brain metastasis and intracranial leptomeningeal metastasis from malignant peripheral nerve sheath tumors: illustrative cases.

Ohno M, Haimoto S, Tsukushi S, Hosoda W, Ohka F, Saito R

Journal of neurosurgery. Case lessons   Vol. 6 ( 3 )   2023.7

Efficacy and safety of bevacizumab, irinotecan, and temozolomide combination for relapsed or refractory pediatric central nervous system embryonal tumor: a single-institution study

Shiba, Y; Motomura, K; Taniguchi, R; Kurimoto, M; Mizutani, K; Ohka, F; Aoki, K; Ito, E; Nishikawa, T; Yamaguchi, J; Kibe, Y; Shimizu, H; Maeda, S; Nakashima, T; Suzuki, H; Muramatsu, H; Takahashi, Y; Saito, R

JOURNAL OF NEUROSURGERY-PEDIATRICS   Vol. 31 ( 6 ) page： 624 - 632   2023.6

Rapid detection of the <i>MYD88</i> L265P mutation for pre- and intra-operative diagnosis of primary central nervous system lymphoma

Yamaguchi, J; Ohka, F; Kitano, Y; Maeda, S; Motomura, K; Aoki, K; Takeuchi, K; Nagata, Y; Hattori, H; Tsujiuchi, T; Motomura, A; Nishikawa, T; Kibe, Y; Shinjo, K; Kondo, Y; Saito, R

CANCER SCIENCE   Vol. 114 ( 6 ) page： 2544 - 2551   2023.6

Clinical characteristics and radiological features of glioblastoma, <i>IDH</i>-wildtype, grade 4 with histologically lower-grade gliomas

Motomura, K; Kibe, Y; Ohka, F; Aoki, K; Yamaguchi, J; Saito, R

BRAIN TUMOR PATHOLOGY   Vol. 40 ( 2 ) page： 48 - 55   2023.4

Easy-to-use machine learning system for the prediction of IDH mutation and 1p/19q codeletion using MRI images of adult-type diffuse gliomas

Nishikawa, T; Ohka, F; Aoki, K; Suzuki, H; Motomura, K; Yamaguchi, J; Maeda, S; Kibe, Y; Shimizu, H; Natsume, A; Innan, H; Saito, R

BRAIN TUMOR PATHOLOGY   Vol. 40 ( 2 ) page： 85 - 92   2023.4

<i>CD79B</i> Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma

Yamaguchi, J; Ohka, F; Lushun, C; Motomura, K; Aoki, K; Takeuchi, K; Nagata, Y; Ito, S; Mizutani, N; Ohno, M; Suzaki, N; Takasu, S; Seki, Y; Kano, T; Wakabayashi, K; Oyama, H; Kurahashi, S; Tanahashi, K; Hirano, M; Shimizu, H; Kitano, Y; Maeda, S; Yamazaki, S; Wakabayashi, T; Kondo, Y; Natsume, A; Saito, R

CANCER MEDICINE   Vol. 12 ( 6 ) page： 7116 - 7126   2023.3

Identification of therapeutic targets exhibiting synthetic lethality with IDH1 inhibitor using the CRISPR/Cas9 system

Maeda, S; Aoki, K; Hinohara, K; Yamaguchi, J; Ohka, F; Natsume, A; Saito, R

CANCER SCIENCE   Vol. 114   page： 1460 - 1460   2023.2

Intra-operative analysis of genetic alterations in brain tumor using rapid quantitative PCR device

Ohka, F; Maeda, S; Yamaguchi, J; Motomura, K; Saito, R

CANCER SCIENCE   Vol. 114   page： 1818 - 1818   2023.2

All-in-One Nanowire Assay System for Capture and Analysis of Extracellular Vesicles from an<i> ex</i><i> Vivo</i> Brain Tumor Model

Chattrairat, K; Yasui, T; Suzuki, S; Natsume, A; Nagashima, K; Iida, M; Zhang, M; Shimada, T; Kato, A; Aoki, K; Ohka, F; Yamazaki, S; Yanagida, T; Baba, Y

ACS NANO   Vol. 17 ( 3 ) page： 2235 - 2244   2023.1

Imaging features of localized <i>IDH</i> wild-type histologically diffuse astrocytomas: a single-institution case series

Kibe, Y; Motomura, K; Ohka, F; Aoki, K; Shimizu, H; Yamaguchi, J; Nishikawa, T; Saito, R

SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page： 23   2023.1

CLINICAL AND MOLECULAR FEATURES OF GLIOBLASTOMA, IDH-WILDTYPE ARISING IN THE SETTING OF LI FRAUMENI SYNDROME

Kibe, Y; Ohka, F; Motomura, K; Aoki, K; Maeda, S; Yamaguchi, J; Nishikawa, T; Mizutani, K; Shimizu, H; Hiramatsu, T; Suzuki, K; Saito, R

NEURO-ONCOLOGY   Vol. 24   page： 154 - 154   2022.11

Endoscopic Trans-Mini-Cylinder Biopsy for Intraparenchymal Brain Lesions

Takeuchi, K; Ohka, F; Nagata, Y; Maeda, S; Tanahashi, K; Araki, Y; Yamamoto, T; Sasaki, H; Mizuno, A; Harada, H; Saito, R

WORLD NEUROSURGERY   Vol. 167   page： E1147 - E1153   2022.11

ROLE OF CD79B Y196 MUTATION IN PCNSL AS A POTENT PREDICTIVE MARKER FOR FAVORABLE RESPONSE TO R-MPV TREATMENT AND DEVELOPMENT OF RAPID ALL-IN-ONE GENOTYPING SYSTEM FOR MOLECULAR MARKERS OF PCNSL

Yamaguchi, J; Ohka, F; Lushun, C; Motomura, K; Aoki, K; Takeuchi, K; Nagata, Y; Ito, S; Mizutani, N; Ohno, M; Suzaki, N; Takasu, S; Seki, Y; Tanahashi, K; Hirano, M; Shimizu, H; Kitano, Y; Maeda, S; Yamazaki, S; Wakabayashi, T; Kondo, Y; Saito, R

NEURO-ONCOLOGY   Vol. 24   page： 18 - 18   2022.11

IDENTIFICATION OF A NOVEL THERAPEUTIC TARGET THAT IS SYNTHETICALLY LETHAL WITH MUTANT IDH INHIBITOR IN GLIOMA USING THE CRISPR/CAS9 GENOME EDITING TECHNOLOGY

Maeda, S; Aoki, K; Hinohara, K; Yamaguchi, J; Ohka, F; Motomura, K; Kibe, Y; Natsume, A; Saito, R

NEURO-ONCOLOGY   Vol. 24   page： 107 - 107   2022.11

Primary central nervous system malignant lymphoma in a patient with rheumatoid arthritis receiving tocilizumab: illustrative case.

Ohno M, Kuramitsu S, Iwakoshi A, Yamaguchi J, Ohka F, Saito R

Journal of neurosurgery. Case lessons   Vol. 4 ( 6 )   2022.8

Direct intracranial invasion of eccrine spiradenocarcinoma of the scalp: a case report and literature review

Kibe, Y; Tanahashi, K; Ohtakara, K; Okumura, Y; Ohka, F; Takeuchi, K; Nagata, Y; Motomura, K; Akahori, S; Mizuno, A; Sasaki, H; Shimizu, H; Yamaguchi, J; Nishikawa, T; Yokota, K; Saito, R

BMC NEUROLOGY   Vol. 22 ( 1 ) page： 223   2022.6

Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors

Nagashima, Y; Nishimura, Y; Eguchi, K; Yamaguchi, J; Haimoto, S; Ohka, F; Takayasu, M; Saito, R

NEUROSPINE   Vol. 19 ( 2 ) page： 262 - 271   2022.6

Supratotal Resection of Gliomas With Awake Brain Mapping: Maximal Tumor Resection Preserving Motor, Language, and Neurocognitive Functions

Motomura, K; Ohka, F; Aoki, K; Saito, R

FRONTIERS IN NEUROLOGY   Vol. 13   page： 874826   2022.5

Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline

Iwama, S; Kobayashi, T; Yasuda, Y; Okuji, T; Ito, M; Ando, M; Zhou, X; Yamagami, A; Onoue, T; Kawaguchi, Y; Miyata, T; Sugiyama, M; Takagi, H; Hagiwara, D; Suga, H; Banno, R; Hase, T; Morise, M; Wakahara, K; Yokota, K; Kato, M; Nishio, N; Tanaka, C; Miyata, K; Ogura, A; Ito, T; Sawada, T; Shimokata, T; Niimi, K; Ohka, F; Ishigami, M; Gotoh, M; Hashimoto, N; Saito, R; Kiyoi, H; Kajiyama, H; Ando, Y; Hibi, H; Sone, M; Akiyama, M; Kodera, Y; Arima, H

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   Vol. 107 ( 4 ) page： E1620 - E1630   2022.3

Reliability of IDH1-R132H and ATRX and/or p53 immunohistochemistry for molecular subclassification of Grade 2/3 gliomas

Nishikawa, T; Watanabe, R; Kitano, Y; Yamamichi, A; Motomura, K; Ohka, F; Aoki, K; Hirano, M; Kato, A; Yamaguchi, J; Maeda, S; Kibe, Y; Saito, R; Wakabayashi, T; Kato, Y; Sato, S; Ogino, T; Natsume, A; Ito, I

BRAIN TUMOR PATHOLOGY   Vol. 39 ( 1 ) page： 14 - 24   2022.1

(11)C-methionine- and (18)F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high (18)F-FDG uptake: A case report.

Tanahashi K, Hirano M, Chalise L, Tsugawa T, Okumura Y, Hase T, Ohka F, Motomura K, Takeuchi K, Nagata Y, Nakahara N, Hashimoto N, Saito R

Surgical neurology international   Vol. 13   page： 372   2022

Dural Arteriovenous Fistula Mimicking a Brain Tumor on Methionine-positron Emission Tomography: A Case Report.

Hanyu T, Nishihori M, Izumi T, Motomura K, Ohka F, Goto S, Araki Y, Yokoyama K, Uda K, Saito R

NMC case report journal   Vol. 9   page： 289 - 294   2022

Newly established patient-derived organoid model of intracranial meningioma

Yamazaki, S; Ohka, F; Hirano, M; Shiraki, Y; Motomura, K; Tanahashi, K; Tsujiuchi, T; Motomura, A; Aoki, K; Shinjo, K; Murofushi, Y; Kitano, Y; Maeda, S; Kato, A; Shimizu, H; Yamaguchi, J; Adilijiang, A; Wakabayashi, T; Saito, R; Enomoto, A; Kondo, Y; Natsume, A

NEURO-ONCOLOGY   Vol. 23 ( 11 ) page： 1936 - 1948   2021.11

Intraoperative seizure outcome of levetiracetam combined with perampanel therapy in patients with glioma undergoing awake brain surgery

Motomura, K; Chalise, L; Shimizu, H; Yamaguchi, J; Nishikawa, T; Ohka, F; Aoki, K; Tanahashi, K; Hirano, M; Wakabayashi, T; Natsume, A

JOURNAL OF NEUROSURGERY   Vol. 135 ( 4 ) page： 998 - 1007   2021.10

Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury

Nagashima, Y; Nishimura, Y; Ohka, F; Eguchi, K; Aoki, K; Ito, H; Nishii, T; Oyama, T; Hara, M; Kitano, Y; Masaki, H; Wakabayashi, T; Natsume, A

CELLS   Vol. 10 ( 10 )   2021.10

Mathematical Modeling and Mutational Analysis Reveal Optimal Therapy to Prevent Malignant Transformation in Grade II IDH-Mutant Gliomas

Aoki, K; Suzuki, H; Yamamoto, T; Yamamoto, KN; Maeda, S; Okuno, Y; Ranjit, M; Motomura, K; Ohka, F; Tanahashi, K; Hirano, M; Nishikawa, T; Shimizu, H; Kitano, Y; Yamaguchi, J; Yamazaki, S; Nakamura, H; Takahashi, M; Narita, Y; Nakada, M; Deguchi, S; Mizoguchi, M; Momii, Y; Muragaki, Y; Abe, T; Akimoto, J; Wakabayashi, T; Saito, R; Ogawa, S; Haeno, H; Natsume, A

CANCER RESEARCH   Vol. 81 ( 18 ) page： 4861 - 4873   2021.9

Long-term survival in patients with primary intracranial germ cell tumors treated with surgery, platinum-based chemotherapy, and radiotherapy: a single-institution study.

Shimizu H, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Yamaguchi J, Yoshida J, Natsume A, Wakabayashi T

Journal of neurosurgery   Vol. 135 ( 2 ) page： 449 - 457   2021.8

Impact of the extent of resection on the survival of patients with grade II and III gliomas using awake brain mapping

Motomura, K; Chalise, L; Ohka, F; Aoki, K; Tanahashi, K; Hirano, M; Nishikawa, T; Yamaguchi, J; Shimizu, H; Wakabayashi, T; Saito, R

JOURNAL OF NEURO-ONCOLOGY   Vol. 153 ( 2 ) page： 361 - 372   2021.6

Urinary MicroRNA-Based Diagnostic Model for Central Nervous System Tumors Using Nanowire Scaffolds

Kitano, Y; Aoki, K; Ohka, F; Yamazaki, S; Motomura, K; Tanahashi, K; Hirano, M; Naganawa, T; Iida, M; Shiraki, Y; Nishikawa, T; Shimizu, H; Yamaguchi, J; Maeda, S; Suzuki, H; Wakabayashi, T; Baba, Y; Yasui, T; Natsume, A

ACS APPLIED MATERIALS & INTERFACES   Vol. 13 ( 15 ) page： 17316 - 17329   2021.4

Expression of programmed cell death ligand-1 by immune cells in the microenvironment is a favorable prognostic factor for primary diffuse large B-cell lymphoma of the central nervous system.

Tsuyuki Y, Ishikawa E, Kohno K, Shimada K, Ohka F, Suzuki Y, Mabuchi S, Satou A, Takahara T, Kato S, Miyagi S, Ozawa H, Kawano T, Takagi Y, Hiraga J, Wakabayashi T, Nakamura S

Neuropathology : official journal of the Japanese Society of Neuropathology   Vol. 41 ( 2 ) page： 99 - 108   2021.4

Trautmann-focused mastoidectomy for a simple, safe presigmoid approach: technical note.

Tanahashi K, Uda K, Araki Y, Takeuchi K, Choo J, Chalise L, Motomura K, Ohka F, Wakabayashi T, Natsume A

Journal of neurosurgery   Vol. 134 ( 3 ) page： 843 - 847   2021.3

<i>Neurod4</i> converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury

Fukuoka, T; Kato, A; Hirano, M; Ohka, F; Aoki, K; Awaya, T; Adilijiang, A; Sachi, M; Tanahashi, K; Yamaguchi, J; Motomura, K; Shimizu, H; Nagashima, Y; Ando, R; Wakabayashi, T; Lee-Liu, D; Larrain, J; Nishimura, Y; Natsume, A

ISCIENCE   Vol. 24 ( 2 ) page： 102074   2021.2

Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review.

Yamaguchi J, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Shimizu H, Natsume A, Wakabayashi T, Saito R

NMC case report journal   Vol. 8 ( 1 ) page： 747 - 753   2021

INFANTILE HEMISPHERIC BRAIN TUMOR WITH A GOPC-ROS1 FUSION GENE: A CASE REPORT

Taniguchi, R; Natsume, A; Kawashima, N; Tanioka, S; Muramatsu, H; Hamada, M; Ichikawa, D; Imaya, M; Narita, K; Kurimoto, M; Shiba, Y; Aoki, K; Ohka, F; Hirato, J; Wakabayashi, T; Takahashi, Y

NEURO-ONCOLOGY   Vol. 22   page： 377 - 377   2020.12

Solitary fibrous tumor/hemangiopericytoma treated with temozolomide plus bevacizumab: a report of four cases and literature review

Maeda, O; Ohka, F; Maesawa, S; Matsuoka, A; Shimokata, T; Mitsuma, A; Urakawa, H; Nakamura, S; Shimoyamas, Y; Nakaguro, SM; Wakabayashi, T; Ando, Y

NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 4 ) page： 631 - 644   2020.11

Neurocognitive and functional outcomes in patients with diffuse frontal lower-grade gliomas undergoing intraoperative awake brain mapping.

Motomura K, Chalise L, Ohka F, Aoki K, Tanahashi K, Hirano M, Nishikawa T, Yamaguchi J, Shimizu H, Wakabayashi T, Natsume A

Journal of neurosurgery   Vol. 132 ( 6 ) page： 1683 - 1691   2020.6

Steroid-responsive recurrent tumefactive demyelination with multiple petechial hemorrhages along non-displaced medullary veins.

Tsuboi T, Harada Y, Suzuki M, Ando T, Atsuta N, Ohka F, Takeuchi K, Taoka T, Ohba S, Nakaguro M, Abe M, Nakashima I, Yoshida M, Katsuno M

Clinical neurology and neurosurgery   Vol. 193   page： 105764   2020.6

Genetic analysis in patients with newly diagnosed glioblastomas treated with interferon-beta plus temozolomide in comparison with temozolomide alone

Natsume Atsushi, Aoki Kosuke, Ohka Fumiharu, Maeda Sachi, Hirano Masaki, Adilijiang Alimu, Motomura Kazuya, Sumi Minako, Nishikawa Ryo, Narita Yoshitaka, Muragaki Yoshihiro, Maruyama Takashi, Ito Tamio, Beppu Takaaki, Nakamura Hideo, Kayama Takamasa, Sato Shinya, Nagane Motoo, Mishima Kazuhiko, Nakasu Yoko, Kurisu Kaoru, Yamasaki Fumiyuki, Sugiyama Kazuhiko, Onishi Takanori, Iwadate Yasuo, Terasaki Mizuhiko, Kobayashi Hiroyuki, Matsumura Akira, Ishikawa Eiichi, Sasaki Hikaru, Mukasa Akitake, Matsuo Takayuki, Hirano Hirofumi, Kumabe Toshihiro, Shinoura Nobusada, Hashimoto Naoya, Aoki Tomokazu, Asai Akio, Abe Tatsuya, Yoshino Atsuo, Arakawa Yoshiki, Asano Kenichiro, Yoshimoto Koji, Shibui Soichiro, Okuno Yusuke, Wakabayashi Toshihiko

JOURNAL OF NEURO-ONCOLOGY   Vol. 148 ( 1 ) page： 17 - 27   2020.5

H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant

Maeda Sachi, Ohka Fumiharu, Okuno Yusuke, Aoki Kosuke, Motomura Kazuya, Takeuchi Kazuhito, Kusakari Hironao, Yanagisawa Nobuyuki, Sato Shinya, Yamaguchi Junya, Tanahashi Kuniaki, Hirano Masaki, Kato Akira, Shimizu Hiroyuki, Kitano Yotaro, Yamazaki Shintaro, Yamashita Shinji, Takeshima Hideo, Shinjo Keiko, Kondo Yutaka, Wakabayashi Toshihiko, Natsume Atsushi

ACTA NEUROPATHOLOGICA COMMUNICATIONS   Vol. 8 ( 1 ) page： 8   2020.2

Multiple metastases to the bone and bone marrow from a 1p/19q-codeleted and <i>IDH2</i>-mutant anaplastic oligodendroglioma: a case report and literature review.

Shimizu H, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Yamaguchi J, Wakabayashi T, Natsume A

Neuro-oncology advances   Vol. 2 ( 1 ) page： vdaa101   2020.1

MACHINE LEARNING TO DETECT GLIOMAS IN URINE-BASED LIQUID BIOPSY

Kitano Yotaro, Aoki Kosuke, Yasui Takao, Motomura Kazuya, Ohka Fumiharu, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Shimizu Hiroyuki, Yamaguchi Junya, Maeda Sachi, Yamazaki Shintaro, Wakabayashi Toshihiko, Natsume Atsushi

NEURO-ONCOLOGY   Vol. 21   page： 151 - 151   2019.11

Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-wild-type Diffuse Astrocytic Gliomas.

Cancer research   Vol. 79 ( 19 ) page： 4814 - 4827   2019.10

Spontaneous Tumor Regression of Intracranial Solitary Fibrous Tumor Originating From the Medulla Oblongata: A Case Report and Literature Review.

Yamaguchi J, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Nishikawa T, Shimizu H, Wakabayashi T, Natsume A

World neurosurgery   Vol. 130   page： 400 - 404   2019.10

Next Generation Sequencing-Based Transcriptome Predicts Bevacizumab Efficacy in Combination with Temozolomide in Glioblastoma.

Adilijiang A, Hirano M, Okuno Y, Aoki K, Ohka F, Maeda S, Tanahashi K, Motomura K, Shimizu H, Yamaguchi J, Wakabayashi T, Natsume A

Molecules (Basel, Switzerland)   Vol. 24 ( 17 )   2019.9

Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma

Ranjit Melissa, Hirano Masaki, Aoki Kosuke, Okuno Yusuke, Ohka Fumiharu, Yamamichi Akane, Kato Akira, Maeda Sachi, Motomura Kazuya, Matsuo Keitaro, Enomoto Atsushi, Ino Yasushi, Todo Tomoki, Takahashi Masahide, Wakabayashi Toshihiko, Kato Takuya, Natsume Atsushi

CELL REPORTS   Vol. 26 ( 9 ) page： 2274 - +   2019.2

Aberrant active-enhancers associated with downregulation of HDAC1-RFP complex overcome chemoresistance in glioblastoma

Hirano Masaki, Melissa Ranjit, Ohka Fumiharu, Aoki Kosuke, Yamamichi Akane, Kato Takuya, Matsuo Keitaro, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

CANCER SCIENCE   Vol. 109   page： 207 - 207   2018.12

Development of anticancer agents targeting long non-coding RNA

Katsushima Keisuke, Natsume Atsushi, Ohka Fumiharu, Shinjo Keiko, Shibata Tatsuhiro, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka

CANCER SCIENCE   Vol. 109   page： 352 - 352   2018.12

ABERRANT ACTIVE-ENHANCERS ASSOCIATED WITH DOWNREGULATION OF HDAC1-RET FINGER PROTEIN COMPLEX OVERCOME CHEMORESISTANCE IN GLIOBLASTOMA

Hirano Masaki, Ranjit Melissa, Ohka Fumiharu, Aoki Kosuke, Yamamichi Akane, Kato Takuya, Matsuo Keitaro, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

NEURO-ONCOLOGY   Vol. 20   page： 111 - 111   2018.11

Validation of a novel molecular RPA classification in glioblastoma (GBM-molRPA) treated with chemoradiation: A multi-institutional collaborative study

Wee Chan Woo, Kim Il Han, Park Chul-Kee, Kim Jin Wook, Dho Yun-Sik, Ohka Fumiharu, Aoki Kosuke, Motomura Kazuya, Natsume Atsushi, Kim Nalee, Suh Chang-Ok, Chang Jong Hee, Kim Se Hoon, Cho Won Kyung, Lim Do Hoon, Nam Do-Hyun, Choi Jung Won, Kim In Ah, Kim Chae-Yong, Oh Young-Taek, Cho Oyeon, Chung Woong-Ki, Kim Sung-Hwan, Kim Eunji

RADIOTHERAPY AND ONCOLOGY   Vol. 129 ( 2 ) page： 347 - 351   2018.11

Supratotal Resection of Diffuse Frontal Lower Grade Gliomas with Awake Brain Mapping, Preserving Motor, Language, and Neurocognitive Functions

Motomura Kazuya, Chalise Lushun, Ohka Fumiharu, Aoki Kosuke, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Wakabayashi Toshihiko, Natsume Atsushi

WORLD NEUROSURGERY   Vol. 119   page： 30 - 39   2018.11

Characterization of lntraoperative Motor Evoked Potential Monitoring for Surgery of the Pediatric Population with Brain Tumors

Motomura Kazuya, Sumita Kayo, Chalise Lushun, Nishikawa Tomohide, Tanahashi Kuniaki, Ohka Fumiharu, Aoki Kosuke, Hirano Masaki, Nakamura Tomohiko, Matsushita Tadashi, Wakabayashi Toshihiko, Natsume Atsushi

WORLD NEUROSURGERY   Vol. 119   page： E1052 - E1059   2018.11

Neuroendoscopic Cylinder Surgery and 5-Aminolevulinic Acid Photodynamic Diagnosis of Deep-Seated Intracranial Lesions

Choo Jungsu, Takeuchi Kazuhito, Nagata Yuichi, Ohka Fumiharu, Kishida Yugo, Watanabe Tadashi, Satoh Yusuke, Nagatani Tetsuya, Kato Kyozo, Wakabayashi Toshihiko, Natsume Atsushi

WORLD NEUROSURGERY   Vol. 116   page： E35 - E41   2018.8

Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion

Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Kato Akira, Hirano Masaki, Motomura Kazuya, Tanahashi Kuniaki, Chalise Lushun, Maeda Sachi, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

BRAIN TUMOR PATHOLOGY   Vol. 35 ( 2 ) page： 106 - 113   2018.4

A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR.

Hirano M, Ohka F, Maeda S, Chalise L, Yamamichi A, Aoki K, Kato A, Tanahashi K, Motomura K, Nishimura Y, Hara M, Shinjo K, Kondo Y, Wakabayashi T, Natsume A

Brain tumor pathology   Vol. 35 ( 2 ) page： 97 - 105   2018.4

Prognostic relevance of genetic alterations in diffuse lower-grade gliomas

Aoki Kosuke, Nakamura Hideo, Suzuki Hiromichi, Matsuo Keitaro, Kataoka Keisuke, Shimamura Teppei, Motomura Kazuya, Ohka Fumiharu, Shiina Satoshi, Yamamoto Takashi, Nagata Yasunobu, Yoshizato Tetsuichi, Mizoguchi Masahiro, Abe Tatsuya, Momii Yasutomo, Muragaki Yoshihiro, Watanabe Reiko, Ito Ichiro, Sanada Masashi, Yajima Hironori, Morita Naoya, Takeuchi Ichiro, Miyano Satoru, Wakabayashi Toshihiko, Ogawa Seishi, Natsume Atsushi

NEURO-ONCOLOGY   Vol. 20 ( 1 ) page： 66 - 77   2018.1

Aberrant super-enhancers associated with downregulation of RET finger protein overcomes chemoresistance in glioblastoma

Hirano Masaki, Ranjit Melissa, Yamamichi Akane, Aoki Kosuke, Ohka Fumiharu, Kato Takuya, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

CANCER SCIENCE   Vol. 109   page： 461 - 461   2018.1

Targeting Dysregulation of EZH2-H3K27me3 as an Effective Treatment for IDH-wildtype Lower Grade Glioma

Ohka Fumiharu, Natsume Atsushi, Suzuki Hiromichi, Aoki Kosuke, Deguchi Shoichi, Katsushima Keisuke, Shinjo Keiko, Wakabayashi Toshihiko, Kondo Yutaka

CANCER SCIENCE   Vol. 109   page： 463 - 463   2018.1

Does ATRX immunohistochemistry deserve a surrogate of 1p/19q codel in grade II, III gliomas?

Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Hirano Masaki, Motomura Kazuya, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

CANCER SCIENCE   Vol. 109   page： 926 - 926   2018.1

Development of anticancer agents targeting long non-coding RNA TUG1

Katsushima Keisuke, Natsume Atsushi, Ohka Fumiharu, Deguchi Shoichi, Shinjo Keiko, Shibata Tatsuhiro, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka

CANCER SCIENCE   Vol. 109   page： 398 - 398   2018.1

Significance of perivascular tumour cells defined by CD109 expression in progression of glioma

Shiraki Yukihiro, Mii Shinji, Enomoto Atsushi, Momota Hiroyuki, Han Yi-Peng, Kato Takuya, Ushida Kaori, Kato Akira, Asai Naoya, Murakumo Yoshiki, Aoki Kosuke, Suzuki Hiromichi, Ohka Fumiharu, Wakabayashi Toshihiko, Todo Tomoki, Ogawa Seishi, Natsume Atsushi, Takahashi Masahide

JOURNAL OF PATHOLOGY   Vol. 243 ( 4 ) page： 468 - 480   2017.12

Organotypic brain explant culture as a drug evaluation system for malignant brain tumors

Minami Noriaki, Maeda Yusuke, Shibao Shunsuke, Arima Yoshimi, Ohka Fumiharu, Kondo Yutaka, Maruyama Koji, Kusuhara Masatoshi, Sasayama Takashi, Kohmura Eiji, Saya Hideyuki, Sampetrean Oltea

CANCER MEDICINE   Vol. 6 ( 11 ) page： 2635 - 2645   2017.11

Remote ischemic preconditioning protects human neural stem cells from oxidative stress

Motomura Ayako, Shimizu Mikiko, Kato Akira, Motomura Kazuya, Yamamichi Akane, Koyama Hiroko, Ohka Fumiharu, Nishikawa Tomohide, Nishimura Yusuke, Hara Masahito, Fukuda Tetsuya, Bando Yasuhiko, Nishimura Toshihide, Wakabayashi Toshihiko, Natsume Atsushi

APOPTOSIS   Vol. 22 ( 11 ) page： 1353 - 1361   2017.11

Negative impact of leukoaraiosis on the incidence of brain metastases in patients with lung cancer

Hayashi Nakamasa, Mitsuya Koichi, Nakasu Yoko, Naito Tateaki, Ohka Fumiharu, Takahashi Toshiaki

JOURNAL OF NEURO-ONCOLOGY   Vol. 135 ( 2 ) page： 299 - 306   2017.11

ABERRANT SUPER-ENHANCERS ASSOCIATED WITH DOWNREGULATION OF RET FINGER PROTEIN OVERCOMES CHEMORESISTANCE IN GLIOBLASTOMA

Hirano Masaki, Ranjit Melissa, Yamamichi Akane, Aoki Kosuke, Ohka Fumiharu, Kato Takuya, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

NEURO-ONCOLOGY   Vol. 19   page： 103 - 103   2017.11

POLYION COMPLEX-MEDIATED INTRAVENOUS DELIVERY OF ANTISENSE OLIGONUCLEOTIDES AGAINST THE NOTCH-REGULATED NON-CODING RNA TUG1 IN GLIOMA

Natsume Atsushi, Katsushima Keisuke, Ohka Fumiharu, Shinjo Keiko, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka

NEURO-ONCOLOGY   Vol. 19   page： 265 - 265   2017.11

IS ATRX IMMUNOCHEMISTRY USEFUL AS A SUBSTITUTE FOR ANALYSIS OF 1p/19q CODELETION IN GRADES II, III GLIOMAS?

Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Hirano Masaki, Motomura Kazuya, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

NEURO-ONCOLOGY   Vol. 19   page： 180 - 180   2017.11

Comparing the Efficacy of DeVIC Therapy and High-dose Methotrexate Monotherapy with Whole-brain Radiation Therapy for Newly-diagnosed Primary Central Nervous System Lymphoma: A Single Institution Study

Chalise Lushun, Motomura Kazuya, Ohka Fumiharu, Hirano Masaki, Hara Masahito, Nishimura Yusuke, Natsume Atsushi, Wakabayashi Toshihiko

ANTICANCER RESEARCH   Vol. 37 ( 9 ) page： 5215 - 5223   2017.9

Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis

Deguchi S., Katsushima K., Hatanaka A., Shinjo K., Ohka F., Wakabayashi T., Zong H., Natsume A., Kondo Y.

ONCOGENE   Vol. 36 ( 32 ) page： 4629 - 4640   2017.8

PHASE I TRIAL OF TEMOZOLOMIDE PLUS BEVACIZUMAB FOR NEWLY DIAGNOSED HIGH-GRADE GLIOMAS IN THE ELDERLY: INTERIM REPORT

Kono M., Arakawa Y., Mineharu Y., Ohka F., Kinoshita M., Nakae S., Miyashita K., Iuchi T., Hirose Y., Natsume A., Nakada M., Sasaki H.

NEURO-ONCOLOGY   Vol. 19   page： 81 - 81   2017.5

Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells

Han Yi-Peng, Enomoto Atsushi, Shiraki Yukihiro, Wang Shen-Qi, Wang Xiaoze, Toyokuni Shinya, Asai Naoya, Ushida Kaori, Ara Hosne, Ohka Fumiharu, Wakabayashi Toshihiko, Ma Jie, Natsume Atsushi, Takahashi Masahide

NEURO-ONCOLOGY   Vol. 19 ( 5 ) page： 636 - 647   2017.5

A novel all-in-one intraoperative genotyping system for IDH1-mutant glioma

Ohka Fumiharu, Yamamichi Akane, Kurimoto Michihiro, Motomura Kazuya, Tanahashi Kuniaki, Suzuki Hiromichi, Aoki Kosuke, Deguchi Shoichi, Chalise Lushun, Hirano Masaki, Kato Akira, Nishimura Yusuke, Hara Masahito, Kato Yukinari, Wakabayashi Toshihiko, Natsume Atsushi

BRAIN TUMOR PATHOLOGY   Vol. 34 ( 2 ) page： 91 - 97   2017.4

Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation

Fumiharu Ohka, Maki Ito, Melissa Ranjit, Takeshi Senga, Ayako Motomura, Kazuya Motomura, Kaori Saito, Keiko Kato, Yukinari Kato, Toshihiko Wakabayashi, Tomoyoshi Soga, Atsushi Natsume

Tumor Biology     2014.3

Current trends in targeted therapies for glioblastoma multiforme

Fumiharu Ohka, Atsushi Natsume, Toshihiko Wakabayashi

Neurology Research International     2012.3

The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma Reviewed

Fumiharu Ohka, Atsushi Natsume, Kazuya Motomura, Yugo Kishida, Yutaka Kondo, Tatsuya Abe, Yoko Nakasu, Hiroki Namba, Kenji Wakai, Takashi Fukui, Hiroyuki Momota, Kenichiro Iwami, Sayano Kinjo, Maki Ito, Masazumi Fujii, Toshihiko Wakabayashi

PLoS ONE     2011.8

Aberrant chromatin remodeling induced by super-enhancer formation in malignant glioma

Grant number：19K09478  2019.4 - 2023.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Ohka Fumiharu

Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury

Grant number：19K09453  2019.4 - 2023.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Nishimura Yusuke

スーパーエンハンサー形成が誘導する悪性脳腫瘍の異常クロマチンリモデリングの解明

2019.4 - 2022.3

科学研究費補助金  基盤研究(C)

大岡　史治

Remodeling of altered epigenetic regulation via targeting epigenetic factor during glioma formation

Grant number：16K20003  2016.4 - 2019.3

Ohka Fumiharu

エピゲノム修飾因子を標的とした悪性脳腫瘍の異常エピゲノムの修復

2016.4 - 2018.3

科学研究費補助金  若手研究(B)

大岡　史治

膠芽腫形成においてエピゲノム異常を誘導する新規分子の同定

2014.4 - 2016.3

科学研究費補助金  若手研究(B)

悪性脳腫瘍におけるゲノムーエピゲノムのクロストークを標的とした新規治療の開発

2014.4 - 2015.3

科学研究費補助金