Organization
Center for Low-temperature Plasma Sciences (cLPS) Professor
Graduate School
Graduate School of Engineering
Title
Professor
TANAKA Hiromasa
Degree 1
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PhD Science （ 2004.3 The University of Tokyo ）
Research Interests 3
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Plasma Medicine
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プラズマバイオ
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低温プラズマ
Research Areas 1
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Others / Others / Plasma Medical Science
Current Research Project and SDGs 1
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低温プラズマによる細胞応答の分子機構解明
Research History 7
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Nagoya University Professor
2019.10
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Nagoya University Associate professor
2019.4 - 2019.9
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Nagoya University Designated associate professor
2017.7 - 2019.3
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Nagoya University Designated lecturer
2014.4 - 2017.6
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Nagoya University Researcher
2011.10 - 2014.3
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University of Toronto Researcher
2010.9 - 2011.8
Country：Canada
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University of California, Irvine Researcher
2004.4 - 2010.8
Country：United States
Education 3
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The University of Tokyo
2001.4 - 2004.3
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The University of Tokyo
1999.4 - 2001.3
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The University of Tokyo
1995.4 - 1999.3
Professional Memberships 2
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日本酸化ストレス学会 日本酸化ストレス学会東海支部理事
2022.6
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応用物理学会
2011.10
Committee Memberships 16
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ISPlasma2024/IC-PLANTS2024/APSPT-13 Executive Committee Chair
2023.4 - 2024.3
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ISPlasma2023/IC-PLANTS2023 Program Committee
2022.5 - 2023.3
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ISPlasma2023/IC-PLANTS2023 Executive Committee Vice-Chair
2022.5 - 2023.3
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ISPlasma2022/IC-PLANTS2022 Program Committee
2021.5 - 2022.3
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Plasma Medicine Editorial Board
2020.5
Committee type：Academic society
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ISPlasma2021/IC-PLANTS2021 Program Committee
2020.5 - 2021.3
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ISPlasma2020/IC-PLANTS2020 Program Committee
2019.5 - 2020.3
Committee type：Academic society
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ISPlasma2020/IC-PLANTS2020 Program Committee
2019.5 - 2020.3
Committee type：Academic society
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IWPCT2020 Program Committee
2019.4 - 2019.3
Committee type：Academic society
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ISPlasma2019/IC-PLANTS2019 Executive Committee
2018.5 - 2019.3
Committee type：Academic society
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Clinical Plasma Medicine Editorial Board
2017.11
Committee type：Academic society
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ISPlasma2018/IC-PLANTS2018 Program Committee
2017.5 - 2018.3
Committee type：Academic society
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ISPlasma2018/IC-PLANTS2018 Executive Committee
2017.5 - 2018.3
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IWPCT2018 Program Committee
2017.4 - 2018.3
Committee type：Academic society
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ISPlasma2016/IC-PLANTS2016 Executive Committee
2015.5 - 2016.3
Committee type：Academic society
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ISPlasma2015/IC-PLANTS2015 Executive Committee
2014.8 - 2015.3
Committee type：Academic society
Awards 4
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第23回プラズマ材料科学賞奨励部門賞
2022.1
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Young Scientist Award, The 10th Asian-European International Conference on Plasma Surface Engineering (AEPSE2015)
2015.9 The 10th Asian-European International Conference on Plasma Surface Engineering (AEPSE2015)
Hiromasa Tanaka
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第8回わかしゃち奨励賞 優秀賞
2014.1 名古屋大学
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Plasma Science Award, 11th Asia-Pacific Conference on Plasma Science and Technology 25th Symposium on Plasma Science for Materials
2012.10
Papers 111
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Direct plasma treatment of caryopses after flowering in brewer's rice cultivar Yamadanishiki enhanced those grain qualities through "Smart Agriculture System".
Hashizume H, Kitano H, Mizuno H, Abe A, Hsiao SN, Yuasa G, Tohno S, Tanaka H, Matsumoto S, Sakakibara H, Kita E, Hirosue Y, Maeshima M, Mizuno M, Hori M
Scientific reports Vol. 14 ( 1 ) page： 29454 2024.11
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Cold plasma irradiation of chitosan: A straight pathway to selective antitumor therapy.
Miron C, Andreica B, Iftime MM, Fifere A, Yamakawa T, Toyokuni S, Mizuno M, Tartau LM, Bejan A, Motooka Y, Kondo T, Sava I, Harabagiu V, Kumagai J, Tanaka A, Tanaka H, Marin L, Hori M
International journal of biological macromolecules Vol. 281 ( Pt 4 ) page： 136513 2024.11
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Low-temperature plasma as a strategy to achieve SDGs.
Tanaka H, Ishikawa K, Toyokuni S
Free radical research Vol. 58 ( 10 ) page： 594 - 595 2024.10
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Ferroptosis induced by plasma-activated Ringer's lactate solution prevents oral cancer progression.
Sato K, Yang M, Nakamura K, Tanaka H, Hori M, Nishio M, Suzuki A, Hibi H, Toyokuni S
Oral diseases Vol. 30 ( 6 ) page： 3912 - 3924 2024.9
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Elaborate cooperation of poly(rC)-binding proteins 1/2 and glutathione in ferroptosis induced by plasma-activated Ringer's lactate. Reviewed
Jiang L, Zheng H, Ishida M, Lyu Q, Akatsuka S, Motooka Y, Sato K, Sekido Y, Nakamura K, Tanaka H, Ishikawa K, Kajiyama H, Mizuno M, Hori M, Toyokuni S
Free radical biology & medicine Vol. 214 page： 28 - 41 2024.3
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Oxygen radical irradiation transforms an organic fertilizer l-tryptophan into an environment and human-friendly bactericide Reviewed
Naoyuki Iwata , Kenji Ishikawa, Yasuhiro Nishikawa, Hiroyuki Kato, Motoyuki Shimizu, Masashi Kato, Hiromasa Tanaka, Masafumi Ito, Masaru Hori
Environmental Technology & Innovation Vol. 33 page： 103496 2024.1
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Plasma-activated medium ameliorates the chemoresistance of human lung adenocarcinoma cells mediated via downregulation of claudin-2 expression. Reviewed
Eguchi H, Yu Y, Yoshino Y, Hara H, Tanaka H, Ikari A
Archives of biochemistry and biophysics Vol. 751 page： 109846 2024.1
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The Possibility of Cancer Therapy with a Combination of Low Temperature Plasma and Hyperthermia Reviewed
TAKASHI KONDO, HIROSHI HASHIZUME, HIROMASA TANAKA, KENJI ISHIKAWA, JUN-ICHI SAITOH MASARU HORI
Thermal Medicine Vol. 39 page： 21 - 30 2023.9
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New betulin imine derivatives with antioxidant and selective antitumor activity Reviewed International coauthorship
Manuela-Maria Iftime, Gabriela Liliana Ailiesei, Camelia Miron, Hiromasa Tanaka, Masaru Hori and Luminita Marin
New Journal of Chemistry Vol. 47 page： 16551 - 16563 2023.8
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Generation and measurement of low-temperature plasma for cancer therapy: a historical review. Invited Reviewed
Ishikawa K, Takeda K, Yoshimura S, Kondo T, Tanaka H, Toyokuni S, Nakamura K, Kajiyama H, Mizuno M, Hori M
Free radical research Vol. 57 ( 3 ) page： 239 - 270 2023.7
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Tetrachloroaurate (III)–induced oxidation increases nonthermal plasma-induced aldehydes Reviewed
Yasumasa Okazaki, Jun Yoshitake, Nanami Ito, Kanako Sasaki, Hiromasa Tanaka, Masaru Hori, Takahiro Shibata, Shinya Toyokuni
Advances in Redox Research Vol. 9 page： 100074 2023.7
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Efficacy of periodic cold plasma treatment in a paddy to produce white-core grains in brewer's rice cultivar Yamadanishiki. Reviewed
Hashizume H, Kitano H, Mizuno H, Abe A, Yuasa G, Tohno S, Tanaka H, Ishikawa K, Matsumoto S, Sakakibara H, Hirosue Y, Maeshima M, Mizuno M, Hori M
Free radical research Vol. 57 ( 3 ) page： 161 - 173 2023.6
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Leukocyte Depletion and Size-Based Enrichment of Circulating Tumor Cells Using a Pressure-Sensing Microfiltration Device Reviewed
D. Onoshima, T. Hase, N. Kihara, D. Kuboyama, H. Tanaka, N. Ozawa, H. Yukawa, M. Sato, K. Ishikawa, Y. Hasegawa, M. Ishii, M. Hori, Y. Baba
ACS Measurement Science Au Vol. 3 ( 2 ) page： 113 - 119 2023.4
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High-performance glass filters for capturing and culturing circulating tumor cells and cancer-associated fibroblasts Reviewed
H. Tanaka, D. Iwata, Y. Shibata, T. Hase, D. Onoshima, N. Yogo, H. Shibata, M. Sato, K. Ishikawa, I. Nagasawa, Y. Hasegawa, M. Ishii, Y. Baba, M. Hori
Scientific Reports Vol. 13 ( 1 ) page： 4130 2023.3
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Organic decomposition and synthesis reactions in lactated solution exposed to nonequilibrium atmospheric pressure plasma Reviewed
Y. Liu, K. Ishikawa, H. Tanaka, C. Miron, T. Kondo, K. Nakamura, M. Mizuno, H. Kajiyama, S. Toyokuni, M. Hori
Plasma Processes and Polymers 2023.2
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Cancer-specific cytotoxicity of Ringer's acetate solution irradiated by cold atmospheric pressure plasma.
Miron C, Ishikawa K, Kashiwagura S, Suda Y, Tanaka H, Nakamura K, Kajiyama H, Toyokuni S, Mizuno M, Hori M
Free radical research Vol. 57 ( 2 ) page： 91 - 104 2023.2
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Effects of plasma-activated Ringer's lactate solution on cancer cells: evaluation of genotoxicity. Reviewed
Liu Y, Nakatsu Y, Tanaka H, Koga K, Ishikawa K, Shiratani M, Hori M
Genes and environment : the official journal of the Japanese Environmental Mutagen Society Vol. 45 ( 1 ) page： 3 2023.1
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Plasma activated Ringer's lactate solution.
Tanaka H, Mizuno M, Ishikawa K, Miron C, Okazaki Y, Toyokuni S, Nakamura K, Kajiyama H, Hori M
Free radical research Vol. 57 ( 1 ) page： 14 - 20 2023.1
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Low-temperature plasma as magic wand to differentiate between the good and the evil
S. Toyokuni, H. Zheng, Y. Kong, K. Sato, K. Nakamura, H. Tanaka, Y. Okazaki
Free Radical Research Vol. 57 ( 1 ) page： 38 - 46 2023.1
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Exposure of low-temperature plasma after vaccination in tongue promotes systemic IgM induction against spike protein of SARS-CoV-2
K. Sato, K. Fujii, H. Tanaka, M. Hori, H. Hibi, S. Toyokuni
Free Radical Research Vol. 57 ( 1 ) page： 30 - 37 2023.1
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Effects of High-Quality Carbon Nanowalls Ionization-Assisting Substrates on Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Performance. Reviewed
Sakai R, Kondo H, Ishikawa K, Ohta T, Hiramatsu M, Tanaka H, Hori M
Nanomaterials (Basel, Switzerland) Vol. 13 ( 1 ) 2022.12
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Indoor Floor Heel Mark Removal Using Spark Discharges and Pressurized Airflow Reviewed
Y. Sakamoto, T. Tsutsumi, H. Tanaka, K. Ishikawa, H. Hashizume, M. Hori
Coatings Vol. 12 2022.12
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Biocompatibility of conformal silicon carbide on carbon nanowall scaffolds Reviewed
K. Ono, T. Koide, K. Ishikawa, H. Tanaka, H. Kondo, A. Sugawara-Narutaki, Y. Jin, S. Yasuhara, M. Hori, W. Takeuchi
Japanese Journal of Applied Physics Vol. 62 2022.11
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Non-thermal plasma elicits ferrous chloride-catalyzed DMPO-OH. Reviewed
Okazaki Y, Ito N, Tanaka H, Hori M, Toyokuni S
Free radical research Vol. 56 ( 9-10 ) page： 595 - 606 2022.9
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Cytotoxicity of plasma-irradiated lactate solution produced under atmospheric airtight conditions and generation of the methyl amino group Reviewed
D. Ito, N. Iwata, K. Ishikawa, K. Nakamura, H. Hashizume, C. Miron, H. Tanaka, H. Kajiyama, S. Toyokuni, M. Mizuno, M. Hori
Applied Physics Express 2022.4
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Scaffolds with isolated carbon nanowalls promote osteogenic differentiation through Runt-related transcription factor 2 and osteocalcin gene expression of osteoblast-like cells Reviewed
T. Ichikawa, K. Ishikawa, H. Tanaka, N. Shimizu, M. Hori
AIP Advances Vol. 12 2022.2
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Low Temperature Plasma for Biology, Hygiene, and Medicine: Perspective and Roadmap Invited Reviewed International coauthorship
M. Laroussi, S. Bekeschus, M. Keidar, A. Bogaerts, A. Fridman, X.P. Lu, K.K. Ostrikov, M. Hori, K. Stapelmann, V. Miller, S. Reuter, C. Laux, A. Mesbah, J. Walsh, C. Jiang, S.M. Thagard, H. Tanaka, D.W. Liu, D. Yan, M. Yusupov
IEEE Transactions on Radiation and Plasma Medical Sciences Vol. 6 ( 2 ) 2022.2
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Tetrachloroaurate (III)-induced oxidation increases non-thermal plasma-induced oxidative stress.
Okazaki Y, Sasaki K, Ito N, Tanaka H, Matsumoto KI, Hori M, Toyokuni S
Free radical research Vol. 56 ( 1 ) page： 17 - 27 2022.1
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Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified. Reviewed
Tanaka H, Hosoi Y, Ishikawa K, Yoshitake J, Shibata T, Uchida K, Hashizume H, Mizuno M, Okazaki Y, Toyokuni S, Nakamura K, Kajiyama H, Kikkawa F, Hori M
Scientific reports Vol. 11 ( 1 ) page： 18488 2021.9
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Non-thermal plasma-induced DMPO-OH yields hydrogen peroxide. Reviewed
Okazaki Y, Tanaka H, Matsumoto KI, Hori M, Toyokuni S
Archives of biochemistry and biophysics Vol. 705 page： 108901 2021.7
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Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate. Reviewed
Jiang L, Zheng H, Lyu Q, Hayashi S, Sato K, Sekido Y, Nakamura K, Tanaka H, Ishikawa K, Kajiyama H, Mizuno M, Hori M, Toyokuni S
Redox biology Vol. 43 page： 101989 2021.7
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Differential data on the responsiveness of multiple cell types to cell death induced by non-thermal atmospheric pressure plasma-activated solutions. Reviewed
Eto K, Ishinada C, Suemoto T, Hyakutake K, Tanaka H, Hori M
Data in brief Vol. 36 page： 106995 2021.6
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Plasma-Treated Solutions (PTS) in Cancer Therapy.
Tanaka H, Bekeschus S, Yan D, Hori M, Keidar M, Laroussi M
Cancers Vol. 13 ( 7 ) 2021.4
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A novel and distinctive mode of cell death revealed by using non-thermal atmospheric pressure plasma: The involvements of reactive oxygen species and the translation inhibitor Pdcd4. Reviewed
Eto K, Ishinada C, Suemoto T, Hyakutake K, Tanaka H, Hori M
Chemico-biological interactions Vol. 338 page： 109403 2021.4
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L-Dehydroascorbate efficiently degrades non-thermal plasma-induced hydrogen peroxide Reviewed
Okazaki Yasumasa, Ishidzu Yuuri, Ito Fumiya, Tanaka Hiromasa, Hori Masaru, Toyokuni Shinya
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS Vol. 700 page： 108762 2021.3
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Preclinical Verification of the Efficacy and Safety of Aqueous Plasma for Ovarian Cancer Therapy
Nakamura Kae, Yoshikawa Nobuhisa, Mizuno Yuko, Ito Miwa, Tanaka Hiromasa, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka, Kajiyama Hiroaki
CANCERS Vol. 13 ( 5 ) 2021.3
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大気圧低温プラズマに対する細胞応答とがん治療への展開 、１．はじめに Invited Reviewed
田中 宏昌、堀 勝
プラズマ・核融合学会誌 page： 107 - 108 2021.3
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Improvement of yield and grain quality by periodic cold plasma treatment with rice plants in a paddy field Reviewed
Hashizume Hiroshi, Kitano Hidemi, Mizuno Hiroko, Abe Akiko, Yuasa Genki, Tohno Satoe, Tanaka Hiromasa, Ishikawa Kenji, Matsumoto Shogo, Sakakibara Hitoshi, Nikawa Susumu, Maeshima Masayoshi, Mizuno Masaaki, Hori Masaru
PLASMA PROCESSES AND POLYMERS Vol. 18 ( 1 ) 2021.1
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Cancer Treatments Using Low-Temperature Plasma.
Tanaka H, Mizuno M, Ishikawa K, Toyokuni S, Kajiyama H, Kikkawa F, Hori M
Current medicinal chemistry Vol. 28 ( 41 ) page： 8549 - 8558 2021
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Laser-induced-plasma-activated medium enables killing of HeLa cells Reviewed
Kurokawa Yukihiro, Takeda Keigo, Ishikawa Kenji, Tanaka Hiromasa, Hori Masaru
APPLIED PHYSICS EXPRESS Vol. 13 ( 10 ) 2020.10
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Adjusted multiple gases in the plasma flow induce differential antitumor potentials of plasma-activated solutions Reviewed
Nakamura Kae, Yoshikawa Nobuhisa, Yoshihara Masato, Ikeda Yoshiki, Higashida Akihiro, Niwa Akihiro, Jindo Takahiro, Tanaka Hiromasa, Ishikawa Kenji, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka, Kajiyama Hiroaki
PLASMA PROCESSES AND POLYMERS Vol. 17 ( 10 ) 2020.10
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Special issue: Advanced applications of plasmas in Life Sciences 2020 Invited
Favia Pietro, Sardella Eloisa, Tanaka Hiromasa
PLASMA PROCESSES AND POLYMERS Vol. 17 ( 10 ) 2020.10
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Hydrogen peroxide in lactate solutions irradiated by non-equilibrium atmospheric pressure plasma Reviewed
Yang Liu, Kenji Ishikawa, Camelia Miron, Hiroshi Hashizume, Hiromasa Tanaka and Masaru Hori
Plasma Sources Science and Technology 2020.9
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Non-thermal plasma-activated lactate solution kills U251SP glioblastoma cells in an innate reductive manner with altered metabolism
Ishikawa Kenji, Hosoi Yugo, Tanaka Hiromasa, Jiang Li, Toyokuni Shinya, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Mizuno Masaaki, Hori Masaru
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS Vol. 688 page： 108414 2020.7
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Plasma-activated medium promotes autophagic cell death along with alteration of the mTOR pathway.
Yoshikawa N, Liu W, Nakamura K, Yoshida K, Ikeda Y, Tanaka H, Mizuno M, Toyokuni S, Hori M, Kikkawa F, Kajiyama H
Scientific reports Vol. 10 ( 1 ) page： 1614 2020.1
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Oxidative stress-dependent and -independent death of glioblastoma cells induced by non-thermal plasma-exposed solutions
Tanaka Hiromasa, Mizuno Masaaki, Katsumata Yuko, Ishikawa Kenji, Kondo Hiroki, Hashizume Hiroshi, Okazaki Yasumasa, Toyokuni Shinya, Nakamura Kae, Yoshikawa Nobuhisa, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru
SCIENTIFIC REPORTS Vol. 9 ( 1 ) page： 13657 2019.9
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Gene Expression of Osteoblast-like Cells on Carbon-Nanowall as Scaffolds during Incubation with Electrical Stimulation.
Ichikawa T, Kondo H, Ishikawa K, Tsutsumi T, Tanaka H, Sekine M, Hori M
ACS applied bio materials Vol. 2 ( 7 ) page： 2698 - 2702 2019.7
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l-Dehydroascorbic acid recycled by thiols efficiently scavenges non-thermal plasma-induced hydroxyl radicals.
Okazaki Y, Tanaka H, Hori M, Toyokuni S
Archives of biochemistry and biophysics Vol. 669 page： 87 - 95 2019.7
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Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner.
Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S
Journal of clinical biochemistry and nutrition Vol. 65 ( 1 ) page： 8 - 15 2019.7
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Plasma-activated solution alters the morphological dynamics of supported lipid bilayers observed by high-speed atomic force microscopy
Yamaoka Sotaro, Kondo Hiroki, Hashizume Hiroshi, Ishikawa Kenji, Tanaka Hiromasa, Hori Masaru
APPLIED PHYSICS EXPRESS Vol. 12 ( 6 ) 2019.6
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A 65-nm CMOS Fully-Integrated Analysis Platform Using an On-Chip Vector Network Analyzer and a Transmission-Line-Based Detection Window for Analyzing Circulating Tumor Cell and Exosome.
Niitsu K, Nakanishi T, Murakami S, Matsunaga M, Kobayashi A, Karim NM, Ito J, Ozawa N, Hase T, Tanaka H, Sato M, Hiroki K, Ishikawa K, Odaka H, Hasegawa Y, Hori M, Nakazato K
IEEE transactions on biomedical circuits and systems Vol. 13 ( 2 ) page： 470 - 479 2019.4
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Non-thermal plasma-activated medium modified metabolomic profiles in the glycolysis of U251SP glioblastoma.
Kurake N, Ishikawa K, Tanaka H, Hashizume H, Nakamura K, Kajiyama H, Toyokuni S, Kikkawa F, Mizuno M, Hori M
Archives of biochemistry and biophysics Vol. 662 page： 83 - 92 2019.2
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Liquid dynamics in response to an impinging low-temperature plasma jet Reviewed
Brubaker T. R., Ishikawa K., Kondo H., Tsutsumi T., Hashizume H., Tanaka H., Knecht S. D., Bilen S. G., Hori M.
JOURNAL OF PHYSICS D-APPLIED PHYSICS Vol. 52 ( 7 ) 2019.2
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Molecular mechanisms of non-thermal plasmainduced effects in cancer cells
Tanaka Hiromasa, Mizuno Masaaki, Ishikawa Kenji, Toyokuni Shinya, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru
BIOLOGICAL CHEMISTRY Vol. 400 ( 1 ) page： 87 - 91 2018.12
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Cytotoxic effects of plasma-irradiated fullerenol
Kanno Daiki, Tanaka Hiromasa, Ishikawa Kenji, Hashizume Hiroshi, Hori Masaru
JOURNAL OF PHYSICS D-APPLIED PHYSICS Vol. 51 ( 37 ) 2018.9
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New hopes for plasma-based cancer treatment Reviewed
Hiromasa Tanaka,Masaaki Mizuno, Kenji Ishikawa, Shinya Toyokuni, Hiroaki Kajiyama, Fumitaka Kikkawa and Masaru Hori
Plasma Vol. 1 page： 150 - 155 2018.8
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Low-autofluorescence fluoropolymer membrane filters for cell filtration
Kihara Naoto, Kuboyama Daiki, Onoshima Daisuke, Ishikawa Kenji, Tanaka Hiromasa, Ozawa Naoya, Hase Tetsunari, Koguchi Ryohei, Yukawa Hiroshi, Odaka Hidefumi, Hasegawa Yoshinori, Baba Yoshinobu, Hori Masaru
JAPANESE JOURNAL OF APPLIED PHYSICS Vol. 57 ( 6 ) 2018.6
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Cytotoxicity of cancer HeLa cells sensitivity to normal MCF10A cells in cultivations with cell culture medium treated by microwave-excited atmospheric pressure plasmas
Takahashi Yohei, Taki Yusuke, Takeda Keigo, Hashizume Hiroshi, Tanaka Hiromasa, Ishikawa Kenji, Hori Masaru
JOURNAL OF PHYSICS D-APPLIED PHYSICS Vol. 51 ( 11 ) 2018.3
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Reduced HeLa cell viability in methionine-containing cell culture medium irradiated with microwave-excited atmospheric-pressure plasma
Takahashi Yohei, Taki Yusuke, Takeda Keigo, Hashizume Hiroshi, Tanaka Hiromasa, Ishikawa Kenji, Hori Masaru
PLASMA PROCESSES AND POLYMERS Vol. 15 ( 3 ) 2018.3
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Glioblastoma Cell Lines Display Different Sensitivities to Plasma-Activated Medium
Tanaka Hiromasa, Mizuno Masaaki, Ishikawa Kenji, Takeda Keigo, Hashizume Hiroshi, Nakamura Kae, Utsumi Fumi, Kajiyama Hiroaki, Okazaki Yasumasa, Toyokuni Shinya, Akiyama Shinichi, Maruyama Shoichi, Kikkawa Fumitaka, Hori Masaru
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES Vol. 2 ( 2 ) page： 99 - 102 2018.3
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Clinical experience with cold plasma in the treatment of locally advanced head and neck cancer Reviewed International coauthorship
Hans-Robert Metelmann, Christian Seebauer, Vandana Miller, Alexander Fridman, Georg Bauer, David B.Graves, Jean-Michel Pouvesle, Rico Rutkowski, Matthias Schuster, Sander Bekeschus, Kristian Wende, Kai Masur, Sybille Hasse, Torsten Gerling, Masaru Hori, Hiromasa Tanaka, Eun Ha Choi, Klaus-Dieter Weltmann,and Thomas von Woedtke
Clinical Plasma Medicine Vol. 9 page： 6 - 13 2018.3
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Effect of Plasma-Activated Lactated Ringer's Solution on Pancreatic Cancer Cells In Vitro and In Vivo
Sato Yusuke, Yamada Suguru, Takeda Shigeomi, Hattori Norifumi, Nakamura Kae, Tanaka Hiromasa, Mizuno Masaaki, Hori Masaru, Kodera Yasuhiro
ANNALS OF SURGICAL ONCOLOGY Vol. 25 ( 1 ) page： 299 - 307 2018.1
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Plasma-activated medium (PAM) kills human cancer-initiating cells
Ikeda Jun-ichiro, Tanaka Hiromasa, Ishikawa Kenji, Sakakita Hajime, Ikehara Yuzuru, Hori Masaru
PATHOLOGY INTERNATIONAL Vol. 68 ( 1 ) page： 23 - 30 2018.1
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Dynamic analysis of reactive oxygen nitrogen species in plasma-activated culture medium by UV absorption spectroscopy
Brubaker Timothy R., Ishikawa Kenji, Takeda Keigo, Oh Jun-Seok, Kondo Hiroki, Hashizume Hiroshi, Tanaka Hiromasa, Knecht Sean D., Bilen Sven G., Hori Masaru
JOURNAL OF APPLIED PHYSICS Vol. 122 ( 21 ) 2017.12
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Intracellular responses to reactive oxygen and nitrogen species, and lipid peroxidation in apoptotic cells cultivated in plasma-activated medium
Furuta Ryo, Kurake Naoyuki, Ishikawa Kenji, Takeda Keigo, Hashizume Hiroshi, Tanaka Hiromasa, Kondo Hiroki, Sekine Makoto, Hori Masaru
PLASMA PROCESSES AND POLYMERS Vol. 14 ( 11 ) 2017.11
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Crystallization of calcium oxalate dihydrate in a buffered calcium-containing glucose solution by irradiation with non-equilibrium atmospheric pressure plasma
Kurake Naoyuki, Tanaka Hiromasa, Ishikawa Kenji, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Mizuno Masaaki, Ikehara Yuzuru, Hori Masaru
JOURNAL OF APPLIED PHYSICS Vol. 122 ( 14 ) 2017.10
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Lipid droplets exhaustion with caspases activation in HeLa cells cultured in plasma-activated medium observed by multiplex coherent anti-Stokes Raman scattering microscopy
Furuta Ryo, Kurake Naoyuki, Takeda Keigo, Ishikawa Kenji, Ohta Takayuki, Ito Masafumi, Hashizume Hiroshi, Tanaka Hiromasa, Kondo Hiroki, Sekine Makoto, Hori Masaru
BIOINTERPHASES Vol. 12 ( 3 ) page： 031006 2017.8
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Novel Intraperitoneal Treatment With Non-Thermal Plasma-Activated Medium Inhibits Metastatic Potential of Ovarian Cancer Cells
Nakamura Kae, Peng Yang, Utsumi Fumi, Tanaka Hiromasa, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka, Kajiyama Hiroaki
SCIENTIFIC REPORTS Vol. 7 ( 1 ) page： 6085 2017.7
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State of the art in medical applications using non-thermal atmospheric pressure plasma Invited Reviewed International coauthorship
Hiromasa Tanaka, Kenji Ishikawa, Masaaki Mizuno, Shinya Toyokuni, Hiroaki Kajiyama, Fumitaka Kikkawa, Hans-Robert Metelmann and Masaru Hori
Reviews of Modern Plasma Physics Vol. 1 page： 1 - 89 2017.7
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Effect of plasma-activated medium on the decrease of tumorigenic population in lymphoma
Wada Naoki, Ikeda Jun-Ichiro, Tanaka Hiromasa, Sakakita Hajime, Hori Masaru, Ikehara Yuzuru, Morii Eiichi
PATHOLOGY RESEARCH AND PRACTICE Vol. 213 ( 7 ) page： 773 - 777 2017.7
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Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy
Shi Lei, Ito Fumiya, Wang Yue, Okazaki Yasumasa, Tanaka Hiromasa, Mizuno Masaaki, Hori Masaru, Hirayama Tasuku, Nagasawa Hideko, Richardson Des R., Toyokuni Shinya
FREE RADICAL BIOLOGY AND MEDICINE Vol. 108 page： 904 - 917 2017.7
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Spatial distributions of O, N, NO, OH and vacuum ultraviolet light along gas flow direction in an AC-excited atmospheric pressure Ar plasma jet generated in open air
Takeda Keigo, Ishikawa Kenji, Tanaka Hiromasa, Sekine Makoto, Hori Masaru
JOURNAL OF PHYSICS D-APPLIED PHYSICS Vol. 50 ( 19 ) 2017.5
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Intraperitoneal Administration of Plasma-Activated Medium: Proposal of a Novel Treatment Option for Peritoneal Metastasis From Gastric Cancer
Takeda Shigeomi, Yamada Suguru, Hattori Norifumi, Nakamura Kae, Tanaka Hiromasa, Kajiyama Hiroaki, Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Fujii Tsutomu, Fujiwara Michitaka, Mizuno Masaaki, Hori Masaru, Kodera Yasuhiro
ANNALS OF SURGICAL ONCOLOGY Vol. 24 ( 5 ) page： 1188 - 1194 2017.5
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Effects of center dot OH and center dot NO radicals in the aqueous phase on H2O2 and NO2- generated in plasma-activated medium
Kurake Naoyuki, Tanaka Hiromasa, Ishikawa Kenji, Takeda Keigo, Hashizume Hiroshi, Nakamura Kae, Kajiyama Hiroaki, Kondo Takashi, Kikkawa Fumitaka, Mizuno Masaaki, Hori Masaru
JOURNAL OF PHYSICS D-APPLIED PHYSICS Vol. 50 ( 15 ) 2017.3
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Behavior of absolute densities of atomic oxygen in the gas phase near an object surface in an AC-excited atmospheric pressure He plasma jet
Takeda Keigo, Kumakura Takumi, Ishikawa Kenji, Tanaka Hiromasa, Sekine Makoto, Hori Masaru
APPLIED PHYSICS EXPRESS Vol. 10 ( 3 ) 2017.3
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Future perspective of strategic non-thermal plasma therapy for cancer treatment
Kajiyama Hiroaki, Utsumi Fumi, Nakamura Kae, Tanaka Hiromasa, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION Vol. 60 ( 1 ) page： 33 - 38 2017.1
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Medical applications of non-thermal atmospheric pressure plasma
Tanaka Hiromasa, Hori Masaru
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION Vol. 60 ( 1 ) page： 29 - 32 2017.1
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Plasma-activated medium selectively eliminates undifferentiated human induced pluripotent stem cells
Matsumoto Ryo, Shimizu Kazunori, Nagashima Takunori, Tanaka Hiromasa, Mizuno Masaaki, Kikkawa Fumitaka, Hori Masaru, Honda Hiroyuki
REGENERATIVE THERAPY Vol. 5 page： 55 - 63 2016.12
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Microfluidic Transport Through Microsized Holes Treated by Nonequilibrium Atmospheric-Pressure Plasma
Ito Takumi, Ishikawa Kenji, Onoshima Daisuke, Kihara Naoto, Tatsukoshi Kentaro, Odaka Hidefumi, Hashizume Hiroshi, Tanaka Hiromasa, Yukawa Hiroshi, Takeda Keigo, Kondo Hiroki, Sekine Makoto, Baba Yoshinobu, Hori Masaru
IEEE TRANSACTIONS ON PLASMA SCIENCE Vol. 44 ( 12 ) page： 3060-3065 2016.12
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Non-thermal atmospheric pressure plasma activates lactate in Ringer's solution for anti-tumor effects
Tanaka Hiromasa, Nakamura Kae, Mizuno Masaaki, Ishikawa Kenji, Takeda Keigo, Kajiyama Hiroaki, Utsumi Fumi, Kikkawa Fumitaka, Hori Masaru
SCIENTIFIC REPORTS Vol. 6 page： 36282 2016.11
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Non-thermal plasma prevents progression of endometriosis in mice
Ishida Chiharu, Mori Masahiko, Nakamura Kae, Tanaka Hiromasa, Mizuno Masaaki, Hori Masaru, Iwase Akira, Kikkawa Fumitaka, Toyokuni Shinya
FREE RADICAL RESEARCH Vol. 50 ( 10 ) page： 1131 - 1139 2016.10
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Biphasic effects of L-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells
Shi Lei, Wang Yue, Ito Fumiya, Okazaki Yasumasa, Tanaka Hiromasa, Mizuno Masaaki, Hori Masaru, Richardson Des R., Toyokuni Shinya
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS Vol. 605 page： 109 - 16 2016.9
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Cell survival of glioblastoma grown in medium containing hydrogen peroxide and/or nitrite, or in plasma-activated medium
Kurake Naoyuki, Tanaka Hiromasa, Ishikawa Kenji, Kondo Takashi, Sekine Makoto, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Mizuno Masaaki, Hori Masaru
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS Vol. 605 page： 102 - 8 2016.9
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Synthesis of calcium oxalate crystals in culture medium irradiated with non-equilibrium atmospheric-pressure plasma
Kurake Naoyuki, Tanaka Hiromasa, Ishikawa Kenji, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumitaka, Mizuno Masaaki, Yamanishi Yoko, Hori Masaru
APPLIED PHYSICS EXPRESS Vol. 9 ( 9 ) 2016.9
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Possible therapeutic option of aqueous plasma for refractory ovarian cancer
Kajiyama Hiroaki, Utsumi Fumi, Nakamura Kae, Tanaka Hiromasa, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka
CLINICAL PLASMA MEDICINE Vol. 4 ( 1 ) page： 14-18 2016.7
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Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium
Utsumi Fumi, Kajiyama Hiroaki, Nakamura Kae, Tanaka Hiromasa, Mizuno Masaaki, Toyokuni Shinnya, Hori Masaru, Kikkawa Fumitaka
ONCOLOGY REPORTS Vol. 35 ( 6 ) page： 3169 - 77 2016.6
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Interplay between Theory and Experiment for Ammonia Synthesis Catalyzed by Transition Metal Complexes.
Tanaka H, Nishibayashi Y, Yoshizawa K
Accounts of chemical research Vol. 49 ( 5 ) page： 987-95 2016.5
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Impact of synergism of nitrite and hydrogen peroxide on cell survivals in Plasma-Activated-Medium (PAM)
Kurake Naoyuki, Tanaka Hiromasa, Ishikawa Kenji, Nakamura Kae, Kajiyama Hiroaki, Kikkawa Fumiaki, Kondo Takashi, Mizuno Masaaki, Takeda Keigo, Kondo Hiroki, Sekine Makoto, Hori Masaru
2016 43RD IEEE INTERNATIONAL CONFERENCE ON PLASMA SCIENCE (ICOPS) page： . 2016
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PLASMA-ACTIVATED MEDIUM AND ITS MEDICAL AND BIOLOGICAL APPLICATIONS
Tanaka Hiromasa, Mizuno Masaaki, Kikkawa Fumitaka, Hori Masaru
2016 43RD IEEE INTERNATIONAL CONFERENCE ON PLASMA SCIENCE (ICOPS) page： . 2016
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Cancer therapy using non-thermal atmospheric pressure plasma with ultra-high electron density
Tanaka Hiromasa, Mizuno Masaaki, Toyokuni Shinya, Maruyama Shoichi, Kodera Yasuhiro, Terasaki Hiroko, Adachi Tetsuo, Kato Masashi, Kikkawa Fumitaka, Hori Masaru
PHYSICS OF PLASMAS Vol. 22 ( 12 ) 2015.12
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Plasma with high electron density and plasma-activated medium for cancer treatment
Tanaka Hiromasa, Mizuno Masaaki, Ishikawa Kenji, Kondo Hiroki, Takeda Keigo, Hashizume Hiroshi, Nakamura Kae, Utsumi Fumi, Kajiyama Hiroaki, Kano Hiroyuki, Okazaki Yasumasa, Toyokuni Shinya, Akiyama Shin'ichi, Maruyama Shoichi, Yamada Suguru, Kodera Yasuhiro, Kaneko Hiroki, Terasaki Hiroko, Hara Hirokazu, Adachi Tetsuo, Iida Machiko, Yajima Ichiro, Kato Masashi, Kikkawa Fumitaka, Hori Masaru
CLINICAL PLASMA MEDICINE Vol. 3 ( 2 ) page： 72-76 2015.12
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Effectiveness of plasma treatment on pancreatic cancer cells
Hattori Norifumi, Yamada Suguru, Torii Koji, Takeda Shigeomi, Nakamura Kae, Tanaka Hiromasa, Kajiyama Hiroaki, Kanda Mitsuro, Fujii Tsutomu, Nakayama Goro, Sugimoto Hiroyuki, Koike Masahiko, Nomoto Shuji, Fujiwara Michitaka, Mizuno Masaaki, Hori Masaru, Kodera Yasuhiro
INTERNATIONAL JOURNAL OF ONCOLOGY Vol. 47 ( 5 ) page： 1655 - 62 2015.11
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Effectiveness of plasma treatment on gastric cancer cells
Torii Koji, Yamada Suguru, Nakamura Kae, Tanaka Hiromasa, Kajiyama Hiroaki, Tanahashi Kuniaki, Iwata Naoki, Kanda Mitsuro, Kobayashi Daisuke, Tanaka Chie, Fujii Tsutomu, Nakayama Goro, Koike Masahiko, Sugimoto Hiroyuki, Nomoto Shuji, Natsume Atsushi, Fujiwara Michitaka, Mizuno Masaaki, Hori Masaru, Saya Hideyuki, Kodera Yasuhiro
GASTRIC CANCER Vol. 18 ( 3 ) page： 635 - 43 2015.7
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Plasma-activated medium induces A549 cell injury via a spiral apoptotic cascade involving the mitochondrial-nuclear network
Adachi Tetsuo, Tanaka Hiromasa, Nonomura Saho, Hara Hirokazu, Kondo Shin-ichi, Hod Masaru
FREE RADICAL BIOLOGY AND MEDICINE Vol. 79 page： 28 - 44 2015.2
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Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration
Ye Fuxiang, Kaneko Hiroki, Nagasaka Yosuke, Ijima Ryo, Nakamura Kae, Nagaya Masatoshi, Takayama Kei, Kajiyama Hiroaki, Senga Takeshi, Tanaka Hiromasa, Mizuno Masaaki, Kikkawa Fumitaka, Hori Masaru, Terasaki Hiroko
SCIENTIFIC REPORTS Vol. 5 page： 7705 2015.1
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Plasma Medical Science for Cancer Therapy. ~toward cancer therapy using non-thermal atmospheric pressure plasma~ Reviewed
H. Tanaka, M. Mizuno, K. Ishikawa, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, Y. Okazaki, S. Toyokuni, S. Maruyama, F. Kikkawa, M. Hori
IEEE Transactions on Plasma Science Vol. 42 ( 12 ) page： 3760-3763 2014.12
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Plasma Medical Science for Cancer Therapy: Toward Cancer Therapy Using Nonthermal Atmospheric Pressure Plasma
Tanaka Hiromasa, Mizuno Masaaki, Ishikawa Kenji, Takeda Keigo, Nakamura Kae, Utsumi Fumi, Kajiyama Hiroaki, Kano Hiroyuki, Okazaki Yasumasa, Toyokuni Shinnya, Maruyama Shoichi, Kikkawa Fumitaka, Hori Masaru
IEEE TRANSACTIONS ON PLASMA SCIENCE Vol. 42 ( 12 ) page： 3760-3764 2014.12
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Direct exposure of non-equilibrium atmospheric pressure plasma confers simultaneous oxidative and ultraviolet modifications in biomolecules
Okazaki Yasumasa, Wang Yue, Tanaka Hiromasa, Mizuno Masaaki, Nakamura Kae, Kajiyama Hiroaki, Kano Hiroyuki, Uchida Koji, Kikkawa Fumitaka, Hori Masaru, Toyokuni Shinya
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION Vol. 55 ( 3 ) page： 207 - 15 2014.11
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Cell survival and proliferation signaling pathways are downregulated by plasma-activated medium in glioblastoma brain tumor cells Reviewed
H. Tanaka, M. Mizuno, K. Ishikawa, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, S. Maruyama, F. Kikkawa, M. Hori
Vol. 2 ( 4 ) page： 207-220 2014.7
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Perspective of strategic plasma therapy in patients with epithelial ovarian cancer: A short review of plasma in cancer treatment
Kajiyama Hiroaki, Nakamura Kae, Utsumi Fumi, Tanaka Hiromasa, Hori Masaru, Kikkawa Fumitaka
JAPANESE JOURNAL OF APPLIED PHYSICS Vol. 53 ( 5 ) 2014.5
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Selective cytotoxicity of indirect nonequilibrium atmospheric pressure plasma against ovarian clear-cell carcinoma
Utsumi Fumi, Kajiyama Hiroaki, Nakamura Kae, Tanaka Hiromasa, Hori Masaru, Kikkawa Fumitaka
SPRINGERPLUS Vol. 3 page： 398 2014
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A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.
Vizeacoumar FJ, Arnold R, Vizeacoumar FS, Chandrashekhar M, Buzina A, Young JT, Kwan JH, Sayad A, Mero P, Lawo S, Tanaka H, Brown KR, Baryshnikova A, Mak AB, Fedyshyn Y, Wang Y, Brito GC, Kasimer D, Makhnevych T, Ketela T, Datti A, Babu M, Emili A, Pelletier L, Wrana J, Wainberg Z, Kim PM, Rottapel R, O'Brien CA, Andrews B, Boone C, Moffat J
Molecular systems biology Vol. 9 page： 696 2013.10
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Yeast G-proteins mediate directional sensing and polarization behaviors in response to changes in pheromone gradient direction.
Moore TI, Tanaka H, Kim HJ, Jeon NL, Yi TM
Molecular biology of the cell Vol. 24 ( 4 ) page： 521-34 2013.2
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Plasma-Activated Medium Selectively Kills Glioblastoma Brain Tumor Cells by Down-Regulating a Survival Signaling Molecule, AKT Kinase Reviewed
H. Tanaka, M. Mizuno, K. Ishikawa, K. Nakamura, H. Kajiyama, H. Kano, F. Kikkawa, M. Hori
Vol. 1 ( 3 ) page： 265-277 2013
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Effect of Indirect Nonequilibrium Atmospheric Pressure Plasma on Anti-Proliferative Activity against Chronic Chemo-Resistant Ovarian Cancer Cells In Vitro and In Vivo
Utsumi Fumi, Kajiyama Hiroaki, Nakamura Kae, Tanaka Hiromasa, Mizuno Masaaki, Ishikawa Kenji, Kondo Hiroki, Kano Hiroyuki, Hori Masaru, Kikkawa Fumitaka
PLOS ONE Vol. 8 ( 12 ) page： e81576 2013
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Real-time in situ electron spin resonance measurements on fungal spores of Penicillium digitatum during exposure of oxygen plasmas
Ishikawa Kenji, Mizuno Hiroko, Tanaka Hiromasa, Tamiya Kazuhiro, Hashizume Hiroshi, Ohta Takayuki, Ito Masafumi, Iseki Sachiko, Takeda Keigo, Kondo Hiroki, Sekine Makoto, Hori Masaru
APPLIED PHYSICS LETTERS Vol. 101 ( 1 ) 2012.7
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Selective killing of ovarian cancer cells through induction of apoptosis by nonequilibrium atmospheric pressure plasma
Iseki Sachiko, Nakamura Kae, Hayashi Moemi, Tanaka Hiromasa, Kondo Hiroki, Kajiyama Hiroaki, Kano Hiroyuki, Kikkawa Fumitaka, Hori Masaru
APPLIED PHYSICS LETTERS Vol. 100 ( 11 ) 2012.3
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The Effect of Replacing Sst2 with the Heterologous RGS4 on Polarization and Mating in Yeast Reviewed
Hiromasa Tanaka and Tau-Mu Yi
Biophysical Journal Vol. 99 page： 1007 - 1017 2010.8
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Reverse engineering a signaling network using alternative inputs Reviewed
Vol. 4 page： e7622/1 - e7622/13 2009.10
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Synthetic morphology using alternative inputs Reviewed
Hiromasa Tanaka and Tau-Mu Yi
PLoS ONE Vol. 4 page： e6946/1-15 - e6946/15 2009.9
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Formin3 is required for assembly of the F-actin structure that mediates tracheal fusion in Drosophila. Reviewed
Hiromasa Tanaka, Etsuko Takasu, Toshiro Aigaki, Kagayaki Kato, Shigeo Hayashi, Akinao Nose
Developmental Biology Vol. 274 page： 413 - 425 2004.10
Books 14
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Plasma Cancer Therapy International journal
（Chapter 6, Plasma-Activated Solutions in Cancer Treatment）
Springer International Publishing 2020.8 （ ISBN:978-3-030-49966-2 ）
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Plasma Medical Science
Hiromasa Tanaka, Masaaki Mizuno, Masaru Hori（Chapter 5.7, Plasma Medicine Innovations in Cancer Therapy: Glioblastoma）
Academic Press 2018.7 （ ISBN:9780128150054 ）
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Comprehensive Clinical Plasma Medicine International journal
Hiromasa Tanaka and Masaru Hori（ Role： Joint author , Chapter 26, Plasma Activated Medium）
Springer International Publishing 2018 （ ISBN:978-3-319-67627-2 ）
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大気圧プラズマ処理における殺菌・医療・バイオ分野への応用
橋爪 博司、田中 宏昌、堀 勝、伊藤 昌文
「工業材料」誌 2017.10
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最先端プラズマバイオ技術
堀 勝、石川 健治、田中宏昌、橋爪 博司、近藤 隆
日本放射線化学会会誌「放射線化学」 2017.10
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ドライプロセスとプラズマ医療科学
田中 宏昌、堀 勝
コロナ社 2016.12
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大気圧低温プラズマによるがん治療
田中 宏昌、堀 勝
放射線生物研究 2016.9
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ドライプロセスと医療
田中 宏昌、堀 勝
月刊ケミカルエンジニヤリング 2016
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プラズマ活性溶液の細胞影響
田中 宏昌、水野 正明、豊國 伸哉、丸山 彰一、小寺 泰弘、足立 哲夫、寺崎 浩子、加藤 昌志、吉川 史隆、堀 勝
プラズマ・核融合学会誌小特集 2015.12
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プラズマ医療の可能性と今後の展望
田中 宏昌、堀 勝（ Role： Joint author）
日本薬学会誌ファルマシア 2015.11
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低温大気圧プラズマの医療応用
田中 宏昌、堀 勝（ Role： Joint author）
週刊医学のあゆみ 2015.7
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プラズマ活性溶液：作用機序解明と臨床応用・産業化を目指して
田中 宏昌、水野 正明、豊國 伸哉、丸山 彰一、小寺 泰弘、吉川 史隆、堀 勝（ Role： Joint author）
福岡医学雑誌 2015.4
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がん細胞へのプラズマ照射の影響
田中 宏昌（ Role： Sole author）
日本機械学会誌 2014.7
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週刊医学のあゆみ・プラズマによるがん治療
田中 宏昌（ Role： Sole author）
医歯薬出版株式会社 2014.3
Presentations 176
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HAuCl4が誘導する脂質過酸化はNTP照射と相乗的に増大し、アスコルビン酸によって抑制される
清水美里、岡崎泰昌、吉武淳、伊藤七海、田中宏昌、堀勝、柴田貴宏、豊国伸哉
第113回日本病理学会総会 2024.3
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大気圧酸化窒素ラジカル源への水蒸気添加効果
杉江 恭輔、呉 準席、田中 宏昌、堀 勝、伊藤 昌文
第71回応用物理学会春季学術講演会 2024.3.22
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がん細胞におけるPAL内オートファジー誘導物質に関する評価
山川 太嗣、中村 佳江、梶山 広明、豊國 伸哉、水野 正明、石川 健治、堀 勝、田中 宏昌
第71回応用物理学会春季学術講演会 2024.3.22
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プラズマ活性化溶液によるイチゴ果実成熟促進
橋爪 博司、松本 省吾、三田 薫、小嶋 美紀子、竹林 由美子、阿部 明子、水野 寛子、坪田 憲紀、湯浅 元気、東野 里江、田中 宏昌、石川 健治、伊藤 昌文、北野 英己、大熊 隆之、広末 庸治、榊原 均、前島 正義、水野 正明、堀 勝
第71回応用物理学会春季学術講演会 2024.3.24
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Radical enhanced growth of GaN on Si with a buffer growth of GaN at low temperature of 600°C International conference
Swathy Jayaprasad, Arun Kumar Dhasiyan, Naohiro Shimizu, Osamu Oda, Kenji Ishikawa, Hiromasa Tanaka and Masaru Hori
ISPlasma2024/IC-PLANTS2024/APSPT-13 2024.3.4
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Selective Killing Effects on Human Breast Cancer Cells by Plasma-Treated L-Arginine Solution International conference
Liyin Du, Carmelia Miron, Kenji Ishikawa, Masaru Hori, Masaaki Mizuno, Shinya Toyokuni, Hiroaki Kajiyama and Hiromasa Tanaka
ISPlasma2024/IC-PLANTS2024/APSPT-13 2024.3.4
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Plasma-Activated Ringer’s Lactate Solution Prevents Oral Cancer Progression through Collagenous Matrix Formation International conference
Kotaro Sato, Ming Yang, Kae Nakamura, Hiromasa Tanaka, Masaru Hori, Hideharu Hibi and ShinyaToyokuni
ISPlasma2024/IC-PLANTS2024/APSPT-13 2024.3.4
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Low-Temperature Plasma- and Radiation-Induced Free Radicals of Solid-State Amino Acids International conference
Takashi Kondo, Jun Kumagai, Ryoichi Hirayama Hiroshi Hashizume, Hiromasa Tanaka, Kenji Ishikawa and Masaru Hori
ISPlasma2024/IC-PLANTS2024/APSPT-13 2024.3.4
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Investigation of Autophagy Inducer on Cancer Cell Treated by PAL International conference
Taishi Yamakawa, Kae Nakamura, Masaaki Mizuno, Shinya Toyokuni, Hiroaki Kajiyama, Masaru Hori, Kenji Ishikawa and Hiromasa Tanaka
ISPlasma2024/IC-PLANTS2024/APSPT-13 2024.3.4
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Mechanisms of selective killing of MCF7 against MCF10A by plasma-activated Ringer’s lactate solution International conference
Ayako Tanaka, Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Camelia Miron, Hiroshi Hashizume, Yasumasa Okazaki, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, and Masaru Hori
ISPlasma2024/IC-PLANTS2024/APSPT-13 2024.3.4
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Control of hMSC differentiation in culturing on carbon nanowalls International conference
Yuki Kojima, Hiroki Kondo, Kenji Ishikawa, Masaru Hori, Hiromasa Tanaka
ISPlasma2024/IC-PLANTS2024/APSPT-13 2024.3.4
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Plasma irradiation induces changes in the survival rate and composition of zebrafish International conference
Yuya Kurebayashi, Kenji Ishikawa, Hiromasa Tanaka, Shinichi Akiyama, Hiroshi Hashizume, Camelia Miron and Masaru Hori
ISPlasma2024/IC-PLANTS2024/APSPT-13 2024.3.4
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低温プラズマ誘発細胞死の温熱による増強-直接照射から照射溶液へ
近藤 隆、村谷珠輝、古澤之裕、齋藤淳一、橋爪博司、田中宏昌、石川健司 、堀 勝
第24回 菅原・大西記念 癌治療増感シンポジウム 2024.2.17
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Sustainable Innovations of the Low-Temperature Plasma-Agriculture Invited International conference
Kenji Ishikawa, Hiroshi Hashizume, Hidemi Kitano, Hiromasa Tanaka, and Masaru Hori
Next-generation Circular Bio Economy Celebration of the 70th Anniversary of Friendship between Japan and Cambodia 2024.2.2
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Increase of yield and quality with cold plasma treatment during crop cultivation Invited International conference
Hiroshi Hashizume, Hidemi Kitano, Shogo Matsumoto, Hiroko Mizuno, Akiko Abe, Kaoru Sanda, Genki Yuasa, Satoe Tohno, Mikiko Kojima, Yumiko Takebayashi, Hiromasa Tanaka, Kenji Ishikawa, Masafumi Ito, Naofumi Kamoshita, yoji Hirosue, Hitoshi Sakakibara, Masayoshi Maeshima, Masaaki Mizuno, and Masaru Hori
5th International Symposium of the Vacuum Society of the Philippines (ISVSP 2024) 2024.1.17
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プラズマ活性乳酸リンゲル液によるマクロファージのM1極性誘導
出野 雄大, 田中 宏昌, 石川 健治, 橋爪 博司, 中村 香江, 豊國 伸哉, 水野 正明, 梶山 広明,堀 勝
第33回日本MRS年次大会 2023.11
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プラズマ照射が引き起こすゼブラフィッシュの生残率と含有成分に対する影響
紅林 佑弥,石川 健治,橋爪 博司,田中 宏昌,秋山 真一,堀 勝
第33回日本MRS年次大会 2023.11
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低温大気圧プラズマ、放射線およびH2O2-UVによるアミノ酸溶液におけるフリーラジカル生成
近藤 隆、熊谷 純、平山亮一、橋爪 博司、田中 宏昌、石川 健治、堀 勝
日本放射線影響学会 2023.11.7
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Selective Cytotoxicity of Plasma-Treated L-Arginine Solution on Human Breast Cancer Cells International conference
Liyin Du, Camelia Miron, Takashi Kondo, Hiromasa Tanaka, Kenji Ishikawa, Masaaki Mizuno, Shinya Toyokuni, Hiroaki Kajiyama, and Masaru Hori
13th Asian-European International Conference on Plasma Surface Engineering (AEPSE 2023) 2023.11.7
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Cellular Response to Electrical Stimulation on Carbon Nanowalls Coated with Silicon Carbide International conference
Koki Ono, Hiroki Kondo, Kenji Ishikawa, Wakana Takeuchi, Kenichi Uehara, Shigeo Yasuhara, Hiromasa Tanaka and Masaru Hori
13th Asian-European International Conference on Plasma Surface Engineering (AEPSE 2023) 2023.11.7
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Evaluation of Autophagy-Inducing Substances in PAL
Taishi Yamakawa,Kae Nakamura, Masaaki Mizuno, Shinya Toyokuni, Hiroaki Kajiyama, Masaru Hori, Kenji Ishikawa and Hiromasa Tanaka
13th Asian-European International Conference on Plasma Surface Engineering (AEPSE 2023) 2023.11.7
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Mechanisms of selective killing of cancer cells against normal cells by plasma-activated Ringer’s lactate solution. International conference
Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Camelia Miron, Hiroshi Hashizume, Yasumasa Okazaki, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, and Masaru Hori
13th Asian-European International Conference on Plasma Surface Engineering (AEPSE 2023) 2023.11.7
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Chemically Active Compounds Formed in Low-temperature Plasma Treated Liquids for Cancer Treatment Invited International conference
Camelia Miron, Hiromasa Tanaka, Taishi Yamakawa, Du Lyin, Hiroki Kondo, Hiroshi Hashizume, Takashi Kondo, Kenji Ishikawa, Shinya Toyokuni, Masaaki Mizuno, and Masaru Hori
Global Plasma Forum in Aomori 2023.10.16
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Plasma-activated solutions invigorate anti-tumor immune response in the intraperitoneal environments of ovarian cancer International conference
Kae Nakamura, Nobuhisa Yoshikawa, Hiromasa Tanaka, Kenji Ishikawa, Masaaki Mizuno, Shinya Toyokuni, Masaru Hori and Hiroaki Kajiyama
Global Plasma Forum in Aomori 2023.10.17
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Ferroptosis induced by plasma-activated Ringer’s lactate solution prevents oral cancer progression
Kotaro Sato, Ming Yang, KaeNakamura, Hiromasa Tanaka, Masaru Hori, Miki Nishio, Akira Suzuki, Hideharu Hibi, Shinya Toyokuni
Global Plasma Forum in Aomori 2023.10.17
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Low-temperature plasma as a ferroptosis inducer in cancer cells Invited International conference
Shinya Toyokuni, Hao Zheng, Yasumasa Okazaki, Kae Nakamura, Hiroaki Kajiyama, Hiromasa Tanaka, Keiji Ishikawa and Masaru Hori
Global Plasma Forum in Aomori 2023.11.16
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Biomedical applications of plasma-activated solutions Invited International conference
Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Camelia Miron, Yasumasa Okazaki, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, Masaru Hori
The 76th Annual Gaseous Electronics Conference (GEC76) 2023.10.10
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Physicochemical investigation of plasma treated polymer solutions for cancer treatment International conference
Camelia Miron, Hiromasa Tanaka, Taishi Yamakawa, Du Lyin, Hiroki Kondo, Hiroshi Hashizume, Takashi Kondo, Kenji Ishikawa, Shinya Toyokuni, Masaaki Mizuno, and Masaru Hori
MACRO 2023 Symposium at ICMPP, IASI 2023.10.6
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アミノ酸水溶液のプラズマ化学および放射線化学－スピン捕捉法による検討
近藤 隆，熊谷 純，橋爪 博司，田中 宏昌，石川 健治，堀 勝
第６６回放射線化学討論会 2023.9.29
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低温プラズマのバイオ応用～プラズマ照射効果～ Invited
石川 健治，近藤 隆，田中 宏昌，豊國 伸哉，中村 香江， 梶山 広明，水野 正明，堀 勝
第６６回放射線化学討論会 2023.9.28
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低温プラズマのバイオ応用 〜農作物栽培におけるプラズマの効果〜 Invited
橋爪博司，北野英己，松本省吾，阿部明子，水野寛子，三田 薫， 湯浅元気，東野里江，田中宏昌，石川健治，伊藤昌文，榊原 均， 広末庸治，鴨下直史，前島正義，水野正明，堀 勝
第６６回放射線化学討論会 2023.9.29
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高密度大気圧プラズマ源によって生成されたイオン種と中性活性種の照射距離依存性
杉江 恭輔、呉 準席、田中 宏昌、堀 勝、伊藤 昌文
第84回応用物理学会秋季学術講演会 2023.9.21
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プラズマ処理によるイチゴ果実中のアントシアニン合成活性化の解析
橋爪 博司、松本 省吾、三田 薫、小嶋 美紀子、竹林 由美子、阿部 明子、水野 寛子、坪田 憲紀、湯浅 元気、東野 里江、田中 宏昌、石川 健治、伊藤 昌文、北野 英己、大熊 隆之、広末 庸治、榊原 均、前島 正義、水野 正明、堀 勝
第84回応用物理学会秋季学術講演会 2023.9.21
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PAL内成分ががん細胞に誘発するオートファジーの評価
山川 太嗣、中村 佳江、梶山 広明、豊國 伸哉、水野 正明、石川 健治、堀 勝、田中 宏昌
第84回応用物理学会秋季学術講演会 2023.9.21
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SiC被覆カーボンナノウォール足場上での電気刺激重畳培養における骨芽細胞の挙動
小野 浩毅、近藤 博基、石川 健治、竹内 和歌奈、上原 賢一、安原 重雄、堀 勝、田中 宏昌
第84回応用物理学会秋季学術講演会 2023.9.21
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カーボンナノウォール上でのヒト間葉系幹細胞の多分化能制御に関する研究
小島 悠暉、近藤 博基、石川 健治、堀 勝、田中 宏昌
第84回応用物理学会秋季学術講演会 2023.9.21
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大気圧プラズマ誘発細胞死の温熱による増強
近藤 隆, 村谷珠輝、古澤之裕、斉藤淳一、橋爪博司、田中宏昌、石川健司、堀 勝
日本ハイパーサーミア学会 2023.9.8
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Plasma-activated solutions for bio-medical application Invited International conference
Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Hiroaki Kajiyama, Shinya Toyokuni, Masaru Hori
3rd Asia pacific conference on plasma and terahertz science(APCOPTS) 2023.8.26
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Plasma-bio application using plasma-activated solutions Invited International conference
Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Hiroaki Kajiyama, Shinya Toyokuni2, Masaru Hori
65th KVS Suumer Annual Conference & IFFM 2023 2023.8.21
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Activation of strawberry fruit ripening with cold plasma treatment during cultivation International conference
Hiroshi Hashizume, Shogo Matsumoto, Kaoru Sanda, Hiroko Mizuno, Akiko Abe, Genki Yuasa, Satoe Tohno, Mikiko Kojima, Yumiko Takebayashi, Hiromasa Tanaka, Kenji Ishikawa, Masafumi Ito, Hidemi Kitano, Hitoshi Sakakibara, Takayuki Okuma, Yoji Hirosue, Masayoshi Maeshima, Masaaki Mizuno, and Masaru Hori
4TH INTERNATIONAL WORKSHOP ON PLASMA AGRICULTURE (IWOPA4) 2023.6.19
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Efficacy of cold plasma for strawberry cultivation on fruit ripening process International conference
Hiroshi Hashizume, Shogo Matsumoto, Hitoshi Sakakibara, Kaoru Sanda, Akiko Abe, Hiroko Mizuno, Kenki Tsubota, Mikiko Kojima, Yumiko Takebayashi, Genki Yuasa, Satoe Tohno, Hiromasa Tanaka, Kenji Ishikawa, Masafumi Ito, Hidemi Kitano, Takayuki Okuma, Yuji Hirosue, Masayoshi Maeshima, Masaaki Mizuno, and Masaru Hori
25th International Symposium on Plasma Chemistry (ISPC25) 2023.5.23
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イチゴ栽培での低温プラズマ処理による果実硬度への効果の検討
橋爪博司, 三田 薫, 水野寛子, 阿部明子, タンマウォン マナスィカン, ミロン カメリア, ブリトン ニコライ, 田中宏昌, 嶋津光鑑, 中野浩平, 堀 勝
第70回応用物理学会春季学術講演会 2023.3.15
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非平衡大気圧プラズマがゼブラフィッシュに及ぼす影響とその機構解明
紅林 佑弥, 石川 健治, 田中 宏昌, 秋山 真一, 橋爪 博司, 堀 勝
第70回応用物理学会春季学術講演会 2023.3.17
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プラズマ活性乳酸リンゲル液によるがん細胞死経路上の オートファジー観察
山川 太嗣，石川 健治，橋爪 博司，田中 宏昌，堀 勝
第70回応用物理学会春季学術講演会 2023.3.17
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カーボンナノウォール足場上での電気刺激重畳培養における ヒト間葉系幹細胞の形態変化
小島 悠暉，近藤 博基, 田中 宏昌 ,石川 健治, 橋爪 博司, 堀 勝
第70回応用物理学会春季学術講演会 2023.3.17
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大気圧プラズマ源の構造の違いが中性ラジカル生成密度に及ぼす影響
杉江恭輔, 呉準席, 田中宏昌, 堀勝, 伊藤昌文
第70回応用物理学会春季学術講演会 2023.3.17
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Chemical analysis of cold atmospheric pressure plasma- activated liquids for cancer treatment Invited International conference
Camelia Miron, Hiromasa Tanaka, Kenji Ishikawa, Takashi Kondo, Hiroki Kondo, Hiroaki Kajiyama, Shinya Toyokuni, Masaaki Mizuno, Masaru Hori
8TH INTERNATIONAL W ORKSHOP O N P LASMA FOR C ANCER T REATMENT (IWPCT2023) 2023.3.15
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Effects of Non-Equilibrium Atmospheric Pressure Plasma on Zebrafish International conference
Yuya Kurebayashi, Kenji Ishikawa, Hiroshi Hashizume, Hiromasa Tanaka, Shinichi Akiyama and Masaru Hori
ISPlasma2023/IC-PLANTS2023 2023.3.8
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Mass Spectrometric Study of Ions and Neutral Species Generated by a High-Density Atmospheric-Pressure Plasma Source International conference
Kyosuke Sugie, Jun-Seok Oh, Hiromasa Tanaka, Masaru Hori and Masafumi Ito
ISPlasma2023/IC-PLANTS2023 2023.3.8
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Plasma-Activated Medium Enhances Anticancer Drug-Induced Toxicity Mediated by Reduciton of Claudin-2 Expression in Lung Adenocarcinoma International conference
Hiroaki Eguchi, Yaqing Yu, Yuta Yoshino, Satoshi Endo, Hiromasa Tanaka, Hirokazu Hara and Akira Ikari
ISPlasma2023/IC-PLANTS2023 2023.3.8
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Investigation of Anti-Tumor Effect Mechanism by Plasma Irradiated L-Arginine Solution International conference
Liyin Du, Carmelia Miron, Saitoshi Kashiwagura, Takashi Kondo, Hiromasa Tanaka, Kenji Ishikawa, Masaaki Mizuno, Shinya Toyokuni, Hiroaki Kajiyama and Masaru Hori
ISPlasma2023/IC-PLANTS2023 2023.3.7
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Morphological Control of Human Mesenchymal Stem Cells with Electrical Stimulation on Carbon Nanowalls. International conference
Yuki Kojima, Hiroki Kondo, Hiromasa Tanaka, Kenji Ishikawa, Hiroshi Hashizume and Masaru Hori
ISPlasma2023/IC-PLANTS2023 2023.3.7
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Morphological Effect of Carbon Nanowalls on Exosome Capture International conference
Takumi Hashimoto, Hiroki Kondo, Hiromasa Tanaka, Kenji Ishikawa, Takayoshi Tsutsumi, Makoto Sekine, Takao Yasui, Yoshinobu Baba, Mineo Hiramatsu and Masaru Hori
ISPlasma2023/IC-PLANTS2023 2023.3.7
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Control of Generating White Core in Grains of Brewer's Rice Cultivar with Direct Plasma Irradiation to Spikelet after Flowering International conference
Hiroshi Hashizume, Hidemi Kitano, Hiroko Mizuno, Akiko Abe, Kaoru Sanda, Shih-Nan Hsiao, Genki Yuasa, Satoe Tohno, Hiromasa Tanaka, Kenji Ishikawa, Shogo Matsumoto, Hitoshi Sakakibara, Yuji Hirosue, Masayoshi Maeshima, Masaaki Mizuno and Masaru Hori
ISPlasma2023/IC-PLANTS2023 2023.3.7
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Cold Plasma Treatment During Cultivation Affects Flesh Firmness of Strawberry Fruits International conference
Hiroshi Hashizume, Kohei Nakano, Kaoru Sanda, Akiko Abe, Hiroko Mizuno, Manasikan Thammawong, Camelia Miron, Nikolay Britun, Teruaki Shimazu, Hiromasa Tanaka and Masaru Hori
ISPlasma2023/IC-PLANTS2023 2023.3.7
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MEMS Nozzle for Capturing Lily Pollen in Array and Fixing on Culture Media International conference
Sachiko Sugiyama, Gang Han, Takayoshi Tsutsumi, Hiromasa Tanaka and Minoru Sasaki
ISPlasma2023/IC-PLANTS2023 2023.3.7
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Effect of Lactate Activated with Nitrogen and Oxygen Radicals on Inactivation of Breast Cancer Cells International conference
Taiga Nishida, Naoyuki Iwata, Tomiyasu Murata, Hiromasa Tanaka, Masaru Hori and Masafumi Ito
ISPlasma2023/IC-PLANTS2023 2023.3.8
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Analysis of Effect of Neutral-Oxygen-Radical Irradiation on Biodegradation of Polyethylene Terephthalate Using High-Performance Liquid Chromatography International conference
Daichi Goto, Naoyuki Iwata, Kenji Ishikawa, Hiroshi Hashizume, Hiromasa Tanaka, Masafumi Ito and Masaru Hori
ISPlasma2023/IC-PLANTS2023 2023.3.8
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Low Temperature Plasma Chemistry of Aqueous Solutions of Amino Acids. A Spin Trapping Study International conference
Takashi Kondo, Hiroshi Hshizume, Jun Kumagai, Hiromasa Tanaka, Kenji Ishikawa and Masaru Hori
ISPlasma2023/IC-PLANTS2023 2023.3.8
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生命エレクトロニクスとしてのプラズマ生命科学 Invited
田中 宏昌、堀 勝
第5回電気系コロキウム 2022.12.7
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Plasma-activated solutions in plasma life science Invited International conference
Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Camelia Miron, Hiroaki Kajiyama, Shinya Toyokuni, and Masaru Hori
The 32nd Annual Meeting of MRS-J 2022.12.7
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Plasma-activated solutions for Plasma Bioscience Invited International conference
Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Camelia Miron, Hiroaki Kajiyama, Shinya Toyokuni, and Masaru Hori
12th International Symposium on Plasma Biosciences (ISPB 2022) 2022.11.24
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Inactivation of Breast Cancer Cells using Nitrogen-Oxygen-Radical-Activated Lactate Ringer's Solution International conference
Taiga Nishida, Naoyuki Iwata, Tomiyasu Murata, Hiromasa Tanaka, Masaru Hori, Masafumi Ito
11th International Conference on Reactive Plasmas/2022 Gaseous Electronics Conference (ICRP-11/GEC2022) 2022.10.5
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Highly efficient exosome capture by carbon nanowalls template International conference
2022.10.4
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Comprehensive analysis of gene expression in PAL-treated glioblastoma cells
Hiromasa Tanaka, Masaaki Mizuno, Ayako Tanaka, Yuki Shibata, Kenji Ishikawa, Hiroki Kondo, Hiroshi Hashizume, Camelia Miron, Yasumasa Okazaki, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, Fumitaka Kikkawa, Masaru Hori
11th International Conference on Reactive Plasmas/2022 Gaseous Electronics Conference (ICRP-11/GEC2022) 2022.10.4
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Various approaches of cold plasma treatment to brewer’s rice plant for improvement of grain quality International conference
Hiroshi Hashizume, Hidemi Kitano, Hiroko Mizuno, Akiko Abe, Kaoru Sanda, Genki Yuasa, Satoe Tohno, Shih-Nan Hsiao, Hiromasa Tanaka, Kenji Ishikawa, Shogo Matsumoto, Hitoshi Sakakibara, Yoji Hirosue, Masayoshi Maeshima, Masaaki Mizuno, Masaru Hori
11th International Conference on Reactive Plasmas/2022 Gaseous Electronics Conference (ICRP-11/GEC2022) 2022.10
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Biological effects of the combination with low temperature plasmas and nanoparticles-platinum and gold-Plasma Medical & Agricultural Application II International conference
Kenji Ishikawa, Takashi Kondo, Hiromasa Tanaka, Masaru Hori, Shinya Toyokuni, Masaaki Mizuno
11th International Conference on Reactive Plasmas/2022 Gaseous Electronics Conference (ICRP-11/GEC2022) 2022.10.7
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細胞運命を制御する応用物理：プラズマ・バイオ研究の融合による革新 Invited
田中 宏昌、水野 正明、石川 健治、梶山 広明、豊國 伸哉、吉川 史隆、堀 勝
第68回応用物理学会秋季学術講演会 2022.9.21
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酸化窒素ラジカル活性化乳酸リンゲル液の乳がん細胞に対する選択的不活性化効果
西田 大河、岩田 直幸、村田 富保、田中 宏昌、堀 勝、伊藤 昌文
第83回 応用物理学会 秋季学術講演 2022.9.20
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プラズマ活性乳酸リンゲル液によるマクロファージの形質発現誘導
出野 雄大, 柏倉 慧史, 田中 宏昌, 石川 健治, 橋爪 博司, 中村 香江, 豊國 伸哉, 水野 正明, 梶山 広明, 堀 勝
第83回 応用物理学会 秋季学術講演 2022.9.20
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非平衡大気圧プラズマを用いた陸上養殖実現に向けた基礎的研究
紅林 佑弥, 石川 健治, 田中 宏昌, 秋山 真一, 橋爪 博司, 堀 勝
第83回 応用物理学会 秋季学術講演 2022.9.20
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Physicochemical Investigation of Plasma Activated Liquids Organically Engineered by Cold Atmospheric Pressure Plasma for Cancer Treatment International conference
Camelia Miron, Kenji Ishikawa, Hiroshi Hashizume, Hiromasa Tanaka, Hiroaki Kajiyama, Shinya Toyokuni, Massaki Mizuno, Masaru Hori
9th International Conference on Plasma Medicine (ICPM9) 2022.6.30
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Effectiveness of Plasma Treatment for Various Rice Cultivation International conference
Hiroshi Hashizume, Hidemi Kitano, Hiroko Mizuno, Akiko Abe, Kaoru Sanda, Genki Yuasa, Satoe Tohno, Hiromasa Tanaka, Kenji Ishikawa, Shogo Matsumoto, Hitoshi Sakakibara, Susumu Nikawa, Masayoshi Maeshima, Masaaki Mizuno, Masaru Hori
9th International Conference on Plasma Medicine (ICPM9) 2022.6.27
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Molecular mechanisms of cell death by plasma-activated solutions in glioblastoma cells Invited International conference
Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Camelia Miron, Hiroaki Kajiyama, Shinya Toyokuni, Masaru Hori
9th International Conference on Plasma Medicine (ICPM9) 2022.6.27
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The aqueous plasma therapy for ovarian cancer ~Aiming for controlling disseminated peritoneal metastasis~ Invited
Hiroaki Kajiyama, Kae Nakamura, Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Shinya Toyokuni, Masaru Hori
9th International Conference on Plasma Medicine (ICPM9) 2022.6.30
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Immunostimulatory Effect of Plasma-Activated Solutions in the Intraperitoneal Environment of Ovarian Cancer International conference
Kae Nakamura, Kazuya Sugiyama, Nobuhisa Yoshikawa, Masato Yoshihara,Tetsuya Matsukawa, Hiromasa Tanaka, Masaaki Mizuno, Shinya Toyokuni, Masaru Hori and Hiroaki Kajiyama
9th International Conference on Plasma Medicine (ICPM9) 2022.6.28
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Gene Expression Analysis of Plasma Activated Ringer’s Lactate Solution Treated Cells International conference
Hiromasa Tanaka,Masaaki Mizuno,Kenji Ishikawa,Hiroshi Hashizume,Kae Nakamura,Hiroaki Kajiyama,Fumitaka Kikkawa,Yasumasa Okazaki,Shinya Toyokuni,Masaru Hori
MRS Spring Meetings & Exhibits 2022.5.11
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中性酸素ラジカル源を用いたポリエチレンテレフタレートの生分解速度の向上
五藤 大智、岩田 直幸、石川 健治、橋爪 博司、田中 宏昌、伊藤 昌文、堀 勝
第69回応用物理学会春季学術講演会 2022.3.24
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稲穂への低温プラズマ照射がもたらす酒造品種玄米の品質向上
橋爪 博司、北野 英己、水野 寛子、阿部 明子、三田 薫、蕭 世男、湯浅 元気、東野 里江、田中 宏昌、石川 健治、松本 省吾、榊原 均、仁川 進、前島 正義、水野 正明、堀 勝
第69回応用物理学会春季学術講演会 2022.3.24
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網羅的解析に基づくプラズマ活性溶液による細胞死の機構解明
田中 宏昌、水野 正明、石川 健治、橋爪 博司、中村 香江、梶山 広明、吉川 史隆、岡崎 康昌、豊國 伸哉、堀 勝
第69回応用物理学会春季学術講演会 2022.3.24
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プラズマ照射乳酸リンゲル液の抗腫瘍成分の評価
伊藤 大貴、岩田 直幸、石川 健治、橋爪 博司、中村 香江、ミロン カメリア、田中 宏昌、梶山 広明、豊國 伸哉、水野 正明、堀 勝
第69回応用物理学会春季学術講演会 2022.3.24
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流液への照射によるプラズマ活性溶液の作製と短寿命活性種の測定
柏倉 慧史、岩田 直幸、石川 健治、橋爪 博司、田中 宏昌、堀 勝
第69回応用物理学会春季学術講演会 2022.3.24
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高効率エクソソーム解析に向けたカーボンナノウォールテンプレートの表面電位制御
橋本 拓海、近藤 博基、田中 宏昌、石川 健治、堤 隆嘉、関根 誠、安井 隆雄、馬場 嘉信、平松 美根男、堀 勝
第69回応用物理学会春季学術講演会 2022.3.24
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Physicochemical Investigation of Plasma Activated Lactate Solutions International conference
Camelia Miron, Nikolay Britun, Hiroki Kondo, Kae Nakamura, Hiroshi Hashizume, Hiromasa Tanaka, Kenji Ishikawa and Masaru Hori
ISPlasma2022/ICPLANTS2022 2022.3.9
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Genotoxic Efects of Plasma Activated Ringer's Lactate Solution on Cancer Cells. International conference
Yang Liu, Yoshimichi Nakatsu, Hiromasa Tanaka, Kazunori Koga, Kenji Ishikawa, Masaharu Shiratani and Masaru Hori
ISPlasma2022/ICPLANTS2022 2022.3.9
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Quality-Increasing Effect of Plasma Treatment in a Paddy on Various Rice Cultivars International conference
Hiroshi Hashizume, Hidemi Kitano, Hiroko Mizuno, Akiko Abe, Kaoru Sanda, Genki Yuasa, Satoe Tohno, Hiromasa Tanaka, Kenji Ishikawa, Shogo Matsumoto, Hitoshi Sakakibara, Susumu Nikawa, Masayoshi Maeshima, Masaaki Mizuno and Masaru Hori
ISPlasma2022/ICPLANTS2022 2022.3.9
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Evaluation of Selective Anti- Cancer Effect in Plasma- Activated Ringer's Lactate Solution Produced by Regulated Surrounding Atmosphere International conference
Daiki Ito, Naoyuki Iwata, Kenji Ishikawa, Hiroshi Hashizume, Kae Nakamura, Camelia Miron, Hiromasa Tanaka, Hiroaki kajiyama, Shinya Toyokuni, Masaaki Mizuno and Masaru Hori
ISPlasma2022/ICPLANTS2022 2022.3.9
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Measurement of RONS concentration in plasma-irradiated artificial seawater International conference
Takumi Yamauchi, Naoyuki Iwata, Kenji Ishikawa, Hiroshi Hashizume, Hiromasa Tanaka, Shinichi Akiyama, and Masaru Hori
2022.3.9
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プラズマ活性乳酸リンゲル液によるがん細胞死の分子機構
田中 宏昌、水野 正明、石川 健治、橋爪 博司、中村 香江、岡崎 康昌、豊國 伸哉、梶山 広明、吉川 史隆、堀 勝
2022.1.24
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低温プラズマ処理による高品質イチゴ果実の安定性生産
橋爪 博司、松本 省吾、坪田 憲紀、三田 薫、水野 寛子、阿部 明子、湯浅 元気、東野 里江、田中 宏昌、石川 健治、伊藤 昌文、北野 英己、榊原 均、仁川 進、大熊 隆之、前島 正義、水野 正明、堀 勝
2022.1.24
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原子状酸素ラジカル処理したポリエチレンテレフタレートの生分解
五藤 大智、岩田 直幸、石川 健治、橋爪 博司、田中 宏昌、伊藤 昌文、上坂 裕之、堀 勝
2022.1.24
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Growth promotion of cultured feed Artemia irradiated with low-temperature plasma International conference
Takumi Yamauchi, Naoyuki Iwata, Kenji Ishikawa, Hiroshi Hashizume, Hiromasa Tanaka, Shin'ichi Akiyama, and Masaru Hori
31st Material Research Society in Japan (MRS-J) 2021.12
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Enhancement of biodegradation technology of polyethylene terephthalate with plasma-pretreatment International conference
Daichi Goto, Naoyuki Iwata, Kenji Ishikawa, Hiroshi Hashizume, Hiromasa Tanaka, Masafumi Ito, and Masaru Hori
31st Material Research Society in Japan (MRS-J) 2021.12
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Cellular Respiration System Affected by Low-temperature Plasma International conference
Hiromasa Tanaka, Shogo Maeda, Shogo Matsumura, Masaaki Mizuno, Kenji Ishikawa, Masafumi Ito, Hiroshi Hashizume, Mikako Ito, Kinji Ohno, Kae Nakamura, Hiroaki Kajiyama, Fumitaka Kikkawa, Yasumasa Okazaki, Shinya Toyokuni, and Masaru Hori
31st Material Research Society in Japan (MRS-J) 2021.12
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Effects of cold plasma treatment with rice seedlings in a paddy on yield and grain quality for different cultivars International conference
Hiroshi Hashizume, Hidemi Kitano, Hiroko Mizuno, Akiko Abe, Kaoru Sanda, Genki Yuasa, Satoe Tohno, Hiromasa Tanaka, Kenji Ishikawa, Shogo Matsumoto, Hitoshi Sakakibara, Susumu Nikawa, Masayoshi Maeshima, Masaaki Mizuno, and Masaru Hori
31st Material Research Society in Japan (MRS-J) 2021.12
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Anti-tumor effect of plasma-activated solution produced by the flowing system International conference
Satoshi Kashiwagura, Naoyuki Iwata, Kenji Ishikawa, Hiroshi Hashizume, Camelia Miron, Kae Nakamura, Hiromasa Tanaka, Hiroaki Kajiyama, Shinya Toyokuni, Masaaki Mizuno, and Masaru Hori
31st Material Research Society in Japan (MRS-J) 2021.12
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Production of plasma-activated Ringer's lactate solution with regulated surrounding atmosphere International conference
Daiki Ito, Naoyuki Iwata, Kenji Ishikawa, Hiroshi Hashizume, Kae Nakamura, Camelia Miron, Hiromasa Tanaka, Hiroaki Kajiyama, Shinya Toyokuni, Masaaki Mizuno, and Masaru Hori
31st Material Research Society in Japan (MRS-J) 2021.12
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Plasma-biological reaction networks and aqueous radical chemistry Invited International conference
Kenji Ishkawa, Camelia Miron, Takashi Kondo, Hiromasa Tanaka, and Masaru Hori
31st Material Research Society in Japan (MRS-J) 2021.12
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Components in plasma-activated Ringer’s lactate solution that induce cell death on U251SP glioblastoma cells International conference
Hiromasa Tanaka, Yugo Hosoi, Kenji Ishikawa, Jun Yoshitake, Takahiro Shibata, Koji Uchida, Hiroshi Hashizume, Masaaki Mizuno, Yasumasa Okazaki, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, Fumitaka Kikkawa, and Masaru Hori
12th Asia-Pacific International Symposium on the Basics and Applications of Plasma Technology (APSPT-12) 2021.12.10
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Low-temperature plasma-activated solutions and metabolic modification Invited International conference
Kenji Ishkawa, Hiromasa Tanaka, Hiroaki Kajiyama, Shinya Toyokuni, Masaaki Mizuno, and Masaru Hori
5th Asia-Pacific Conference on Plasma Physics (AAPPS-DPP2021) 2021.9.27
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酸素ラジカル照射したl-トリプトファン溶液の殺菌効果
岩田 直幸、石川 健治、橋爪 博司、田中 宏昌、伊藤 昌文、堀 勝
2021年第82回応用物理学会秋季学術講演会 2021.9.12
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プラズマ活性溶液及びプラズマ照射が細胞呼吸に与える影響
田中 宏昌、前田 昌吾、松村 翔伍、水野 正明、石川 健治、伊藤 昌文、橋爪 博司、伊藤 美佳子、大野 欽司、中村 香江、梶山 広明、吉川 史隆、岡崎 泰昌、豊國 伸哉、堀 勝
2021年第82回応用物理学会秋季学術講演会 2021.9.12
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流液への照射によるプラズマ活性溶液の大量作製と抗腫瘍効果の評価
柏倉 慧史、岩田 直幸、石川 健治、橋爪 博司、カメリア ミロン、中村 香江、田中 宏昌、梶山 広明、豊國 伸哉、水野 正明、堀 勝
2021年第82回応用物理学会秋季学術講演会 2021.9.12
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CNW細胞培養基板上のSiCコートが細胞増殖に与える影響
小野 浩毅、小出 崇史、石川 健治、田中 宏昌、近藤 博基、鳴瀧 彩絵、金 勇、安原 重雄、堀 勝、竹内 和歌奈
2021年第82回応用物理学会秋季学術講演会 2021.9.13
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Arパージ下でプラズマ照射した乳酸リンゲル液の抗腫瘍効果の評価
伊藤 大貴、岩田 直幸、石川 健治、橋爪 博司、中村 香江、ミロン カメリア、田中 宏昌、梶山 広明、豊國 伸哉、水野 正明、堀 勝
2021年第82回応用物理学会秋季学術講演会 2021.9.13
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ポリエチレンテレフタラートの新しい生分解プラズマ技術の開発
五藤 大智、岩田 直幸、石川 健治、橋爪 博司、田中 宏昌、伊藤 昌文、堀 勝
2021年第82回応用物理学会秋季学術講演会 2021.9.12
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低温プラズマ照射した養殖餌料アルテミアの成長促進
山内 拓海、石川 健治、田中 宏昌、秋山 真一、橋爪 博司、堀 勝
2021年第82回応用物理学会秋季学術講演会 2021.9.13
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Development of new biodegradation technology by surface modification of polyethylene terephthalate using atmospheric pressure plasma International conference
Daichi Goto, Naoyuki Iwata, Kenji Ishikawa, Hiroshi Hashizume, HiromasaTanaka, Masafumi Ito, and Masaru Hori
Interfinish 2020 World Congress 2021.9.7
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Cell death mechanisms by plasma activated medium and plasma activated Ringer's lactate solution Invited International conference
Masaru Hori, Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Kae Nakamura, Hiroaki Kajiyama, Yasumasa Okazaki, Shinya Toyokuni, and Fumitaka Kikkawa
2021.8.6
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Efficacy for Rice Plant Growth with Plasma Irradiation to Seeds International conference
Hiroshi Hashizume, HidemiKitano, Hiroko Mizuno,Akiko Abe, Genki Yuasa, SatoeTohno, Hiromasa Tanaka, Kenji Ishikawa,Shogo Matsumoto, Hitoshi Sakakibara, Susumu Nikawa, Masayoshi Maeshima, Masaaki Mizuno and Masaru Hori
8th International Conference on Plasma Medicine 2021.8.4
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Plasma-activated Solution Promotes Wound Healing in Diabetic Mouse via Keratinocytes Activation International conference
2021.8.3
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Analysis of Cellular Respiration in Plasma-activated Solutions-treated Cancer Cells International conference
Hiromasa Tanaka, Shogo Maeda, Masaaki Mizuno, Kenji Ishikawa, Kae Nakamura, Hiroaki Kajiyama, Yasumasa Okazaki, Shinya Toyokuni, M. Ito, K. Ohno, Fumitaka Kikkawa, and Masaru Hori
8th International Conference on Plasma Medicine 2021.8.6
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Indirect plasma application Invited International conference
Hiromasa Tanaka and Masaru Hori
7th International Workshop on Plasma for Cancer Treatment (IWPCT-2021) 2021.6.28
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気相反応制御によるプラズマ活性溶液の反応と抗腫瘍効果の究明
伊藤 大貴、石川 健治、橋爪 博司、田中 宏昌、堀 勝
2021年第68回応⽤物理学会春季学術講演会
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酸素ラジカル処理肥料溶液を用いた殺菌でのピロール化合物の重要性
岩田 直幸、石川 健治、橋爪 博司、田中 宏昌、伊藤 昌文、堀 勝
2021年第68回応⽤物理学会春季学術講演会
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Dependence of Nitrogen Concentrations on Cytotoxicity of Air-Free Ar-N2 Mixed Atmospheric Pressure Plasma-activeted Lactated Solutions International conference
Daiki Ito, Kenji Ishikawa, Hiroshi Hashizume, Hiromasa Tanaka, Takayoshi Tsutsumi, Hiroki Kondo, Makoto Sekine and Masaru Hori
13th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 14th International Conference on Plasma-Nano Technology & Science （ISPlasma2021/ICPLANTS2021）
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Dependence of nitrogen concentrations on cytotoxicity of air-free Ar-N2 mixed atmospheric pressure plasma-activeted lactated solutions International conference
Daiki Ito, Kenji Ishikawa, Hiroshi Hashizume, Hiromasa Tanaka, T. Tsutsumi, M. Sekine, and M. Hori
13th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 14th International Conference on Plasma-Nano Technology & Science （ISPlasma2021/IC-PLANTS2021）
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Quality increase of fruits with plasma treatment on strawberry cultivation International conference
Hiroshi Hashizume, Shogo Matsumoto, Kenki Tsubota, Kaoru Sanda, Hiroko Mizuno, Akiko Abe, Genki Yuasa, Satoe Tohno, Hiromasa Tanaka, Kenji Ishikawa, Masafumi Ito, Hidemi Kitano, Hitoshi Sakakibara, Susumu Nikawa, Takayuki Okuma, Masayoshi Maeshima,Masaaki Mizuno, and Masaru Hori
13th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 14th International Conference on Plasma-Nano Technology & Science （ISPlasma2021/IC-PLANTS2021）
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Reversible change in surface morphology of lipid bilayer induced by indirect plasma irradiation International conference
Hiroki Kondo, Takuya Tonami, Sotaro Yamaoka, Hiromasa Tanaka, Kenji Ishikawa, Makoto Sekine, Masafumi Ito and Masaru Hori
13th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 14th International Conference on Plasma-Nano Technology & Science （ISPlasma2021/IC-PLANTS2021）
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Efficacy of plasma treatment in a paddy field for yield and grain quality of rice International conference
Kaoru Sanda, Hiroshi Hashizume, Hidemi Kitano, Hiroko Mizuno, Akiko Abe, Genki Yuasa, Satoe Tohno, Hiromasa Tanaka, Kenji Ishikawa, Shogo Matsumoto, Hitoshi Sakakibara, Susumu Nikawa, Masayoshi Maeshima, Masaaki Mizuno, and Masaru Hori.
13th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 14th International Conference on Plasma-Nano Technology & Science （ISPlasma2021/IC-PLANTS2021）
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Effects of non-equilibrium atmospheric pressure plasma on aquaculture feed International conference
Takumi Yamauchi, Kenji Ishikawa, Hiromasa Tanaka, Shin'ichi Akiyama, Hiroshi Hashizume and Masaru Hori
13th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 14th International Conference on Plasma-Nano Technology & Science （ISPlasma2021/ICPLANTS2021）
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Enhancement of alcohol production of budding yeast by direct irradiation of nonequilibrium atmospheric pressure plasma International conference
Shogo Matsumura, Kenji Ishikawa, Hiromasa Tanaka, Hiroshi Hashizume, Masafumi Ito and Masaru Hori
13th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 14th International Conference on Plasma-Nano Technology & Science （ISPlasma2021/IC-PLANTS2021）
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Selective killing effects of organics in plasma-activated Ringer’s solutions International conference
Yuki Suda, Kenji Ishikawa, Hiroshi Hashizume, Hiromasa Tanaka and Masaru Hori
13th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 14th International Conference on Plasma-Nano Technology & Science （ISPlasma2021/IC-PLANTS2021）
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Dependency of Bactericidal Effect in Oxygen-Radical Exposed E. Coli Suspension Containing L-Tryptophan on its Concentration International conference
Naoyuki Iwata, Kenji Ishikawa, Hiroshi Hashizume, Hiromasa Tanaka, Jun-Seok Oh, Masafumi Ito and Masaru Hori
13th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 14th International Conference on Plasma-Nano Technology & Science （ISPlasma2021/IC-PLANTS2021）
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Apoptosis-inducing Activity through Caspase-9 of Radical-Activated Lactate Ringers Solution for Melanoma Cells International conference
Yuki Hori, Tomiyasu Murata, Hiromasa Tanaka, Masaru Hori and Masafumi Ito
13th International Symposium on Advanced Plasma Science and Its Applications for Nitrides and Nanomaterials / 14th International Conference on Plasma-Nano Technology & Science （ISPlasma2021/ICPLANTS2021）
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PLASMA APPLICATIONS FOR AGRICULTURE FROM SEEDS TO FIELD Invited International conference
Hiroshi Hashizume, Hiroko Mizuno, Akiko Abe, Kenki Tsubota, Genki Yuasa, Satoe Tohno, Mikiko Kojima, Yumiko Takebayashi3, Hiromasa Tanaka, Kenji Ishikawa, Masafumi Ito, Hidemi Kitano, Shogo Matsumoto, Hitoshi Sakakibara, Takayuki Okuma, Susumu Nikawa, Masayoshi Maeshima, Masaaki Mizuno, and Masaru Hori
3RD INTERNATIONAL WORKSHOP ON PLASMA AGRICULTURE IWOPA3 （2021）
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扁形動物を用いた低温プラズマによる再生・分化の制御とその機構解明
田中 宏昌、水野 正明、 堀 勝、梅園 良彦、阿形 清和
プラズマバイオコンソーシアム研究報告会
-
プラズマ医療科学の最先端 Invited
堀 勝、田中宏昌
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Antitumor effect of plasma-activated Ringer's acetate solution International conference
Yuki SudaU, Kenji Ishikawa, Hiroshi Hashizume, Hiromasa Tanaka, Takayoshi Tsutsumi, Hiroki Kondo, Makoto Sekine, Masaru Hori
第30回日本MRS年次大会 国際シンポジウム プラズマサイエンス
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Cell Death Mechanisms of Plasma-Activated Solutions-Treated Cancer Cells Invited International conference
Masaru Hori, Hiromasa Tanaka, Kenji Ishikawa, Shinya Toyokuni, Hiroaki Kajiyama, Masaaki Mizuno
第30回日本MRS年次大会 国際シンポジウム プラズマサイエンス
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Enhancement of alcohol fermentation of budding yeast by direct treatments of non-equilibrium atmospheric pressure plasma International conference
Shogo Matsumura, Kenji Ishikawa, Hiromasa Tanaka, Hiroshi Hashizume, Masafumi Ito, Masaru Hori
第30回日本MRS年次大会 国際シンポジウム プラズマサイエンス
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Apoptosis-inducing activity through caspase pathway in melanoma cells treated by radical-activated lactate Ringer's solution International conference
Yuki Hori, Tomiyasu Murata, Hiromasa Tanaka, Masaru Hori, Masafumi Ito
73th Annual Gaseous Electronics Virtual Conference
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Metabolomic profiles of glioblastoma in plasma-activated solutions International conference
Kenji Ishikawa, Hiromasa Tanaka, Li Jiang, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, Fumitaka Kikkawa, Masaaki Mizuno, Camelia Miron, Masaru Hori
73th Annual Gaseous Electronics Virtual Conference
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Plasma activated Ringer's lactate solution affected cellular respiratory system on HeLa cells. International conference
Hiromasa Tanaka, Shogo Maeda, Kae Nakamura, Hiroshi Hashizume, Kenji Ishikawa, Mikako Ito, Kinji Ohno, Masaaki Mizuno, Shinya Toyokuni, Hiroaki Kajiyama, Fumitaka Kikkawa, Masaru Hori
73th Annual Gaseous Electronics Virtual Conference
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Effectiveness of cold plasma treatment during rice cultivation for growth and yield International conference
Hiroshi Hashizume, Hidemi Kitano, Hiroko Mizuno, Akiko Abe, Genki Yuasa, Satoe Tohno, Hiromasa Tanaka, Kenji Ishikawa, Shogo Matsumoto, Hitoshi Sakakibara, Susumu Nikawa, Masayoshi Maeshima, Masaaki Mizuno, Masaru Hori
73rd Annual Gaseous Electronics Virtual Conference
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Physicochemical investigation of plasma activated liquids International conference
Camelia Miron, Yang Liu, Naoyuki Iwata, Kenji Ishikawa, Hiromasa Tanaka, Shinya Toyokuni, Masaaki Mizuno, Masaru Hori
73th Annual Gaseous Electronics Virtual Conference
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酒米品種イネ栽培における低温プラズマ処理の品質への効果
橋爪 博司、北野 英己、水野 寛子、阿部 明子、湯浅 元気、東野 里江、田中 宏昌、石川 健治、松本 省吾、榊原 均、仁川 進、前島 正義、水野 正明、堀 勝
第81回応用物理学会秋季学術講演会
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様々なプラズマ活性溶液による細胞死の作用機序 Invited
田中 宏昌、堀 勝
第81回応用物理学会秋季学術講演会
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ラジカル活性乳酸リンゲル液で処理されたメラノーマ細胞におけるカスパーゼ依存性アポトーシス
堀 侑己、村田 富保、田中 宏昌、堀 勝、伊藤 昌文
第81回応用物理学会秋季学術講演会
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プラズマ活性乳酸処理グリオーマのメタボロミクス解析(2)
石川 健治、田中 宏昌、橋爪 博司、ミロン カメリア、蒋 麗、豊國 伸哉、中村 香江、梶山 広明、吉川 史隆、水野 正明、堀 勝
第81回応用物理学会秋季学術講演会
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プラズマ誘起生体反応の機序解明最前線～何が何処まで解ってきたか～「プラズマ活性溶液による細胞死の作用機序」 Invited
田中 宏昌、堀 勝
第67回応用物理学会春季学術講演会
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Plasma cancer treatments in the current plasma medical science Invited International conference
Hiromsasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Shinya Toyokuni, Hiroaki Kajiyama, Fumitaka Kikkawa and Masaru Hori
29th Annual Meeting of MRS-J
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低温プラズマ医療科学の最前線 Invited
田中 宏昌、堀 勝
大学共同利用機関法人自然科学研究機構核融合科学研究所と国立大学法人名古屋大学低温プラズマ科学研究センターとの連携・協力に関する協定書調印式・記念講演会
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プラズマ照射に対する生体内応答ネットワーク解析 Invited
田中 宏昌、堀 勝
令和元年度 東北大学電気通信研究所 共同プロジェクト研究会応用物理学会プラズマエレクトロニクス分科会 第３２回プラズマ新領域研究会物理 化学混成系プラズマにおける情報系機能発現～プラズマ反応場をネットワーク科学として捉える～
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Gene expression analyses revealed the differences of intracellular molecular mechanisms of PAM- and PAL-induced cell death. Invited International conference
H. Tanaka, M. Mizuno, Y. Katsumata, K. Ishikawa, H. Kondo, H. Hashizume, Y. Okazaki, S. Toyokuni, K. Nakamura, N. Yoshikawa, H. Kajiyama, F. Kikkawa, and M. Hori
The 12th Asian-European International Conference on Plasma Surface Engineering
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プラズマ医療研究の現状と今後の展望 Invited
田中 宏昌、堀勝
プラズマバイオコンソーシアム第2回ワークショップ 2019.8.23
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プラズマ活性溶液 Invited
田中 宏昌、堀勝
第2回将来ビジョン・戦略委員会 2019.6.19
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Minicourse: Plasma & Cancer, Plasma activated media for cancer treatment Invited International conference
H. Tanaka, M. Hori
The 6th International Workshop on Plasma for Cancer Treatment
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Effectiveness and Safety of Plasma Activated Medium Invited International conference
H. Tanaka, M. Mizuno, K. Ishikawa, S. Toyokuni, H. Kajiyama, F. Kikkawa, M. Hori
A Meeting of the Materials Research Society
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プラズマ活性溶液の合成・分析の現状と今後の展望 Invited
田中 宏昌、堀 勝
学振136委員会 第138回研究会 『プラズマ誘起による液中化学反応技術の現状と将来展望」 2018.10.25
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Plasma medical science and Plasma-activated medium Invited International conference
H. Tanaka, M. Mizuno, K. Ishikawa, S. Toyokuni, H. Kajiyama, F.Kikkawa and M. Hori
MRSJ2017
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A Challenge of Plasma Activated Medium to the Medical Care Invited International conference
H. Tanaka, M. Mizuno, F. Kikkawa, and M. Hori
28th Annual Conference of the European Society for Biomaterials
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プラズマ癌治療の未来を語る Invited
田中 宏昌
新学術領域「プラズマ医療科学の創成」若手ワークショップ 2017.5.19
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新規プラズマ活性溶液の合成に向けた将来展望 Invited
田中 宏昌
第4回北陸プラズマ医療応用研究会 2017.1.5
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A new cancer therapy using low temperature atmospheric pressure plasma Invited International conference
H. Tanaka, M. Mizuno, F. Kikkawa, and M. Hori
World Congress on Cancer Research and Therapy
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プラズマ科学と生命科学の融合 Invited
田中 宏昌
熊本大学大学院自然科学研究科プロゼミ 2016.9.13
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Plasma-activated medium and Cancer, 6th international conference on plasma medicine Invited International conference
H. Tanaka, M. Mizuno, K. Ishikawa, K. Takeda, H. Kondo, H. Hashizume, K. Nakamura, H. Kajiyama, H. Kano, Y. Okazaki, S. Toyokuni, S. Maruyama, F. Kikkawa, and M. Hori
6th international conference on plasma medicine
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ドライプロセスと医療 Invited
田中 宏昌、堀 勝
夏季実習セミナー（II)“ドライプロセスの基礎と薄膜作製” 2016.8.25
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Plasma-activated medium as a novel cancer therapeutic approach Invited International conference
H. Tanaka, M. Mizuno, F. Kikkawa, and M. Hori
6th International Symposium on Plasma Biosciences (ISPB 2016)
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INTRACELLULAR MOLECULAR MECHANISMS OF CANCER CELL DEATH USING PLASMA-ACTIVATED MEDIUM Invited International conference
H. Tanaka, M. Mizuno, K. Ishikawa, K. Takeda, H. Hashizume, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, Y. Okazaki, S. Toyokuni, S. Maruyama, T. Adachi, H. Kaneko, H. Terasaki, Y. Kodera, F. Kikkawa, and M. Hori
The 3rd International Workshop on Plasma for Cancer Treatment
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非熱大気圧プラズマのがん治療への応用とその細胞内分子機構 Invited
田中 宏昌、水野 正明、豊國 伸哉、丸山 彰一、小寺 泰弘、寺崎 浩子、足立 哲夫、加藤 昌志、吉川 史隆 、堀 勝
第19回 若手科学者によるプラズマ研究会
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Plasma Medical Innovation in Japan Invited International conference
H. Tanaka and M. Hori
Special Lecture by Prof. Zdenko Machala 2016.3.11
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がん細胞へのプラズマ影響 Invited
田中 宏昌 、堀 勝
153委員会 プラズマスクール---プラズマ医療の基礎と応用 2016.2.8
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大気圧プラズマを利用したがん治療 Invited
田中 宏昌、水野 正明、吉川 史隆、堀 勝
第18回癌治療増感研究会シンポジウム
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Progress of Plasma Medical Science Innovation Invited International conference
H. Tanaka, M. Mizuno, F. Kikkawa, and M. Hori
Sungkyunkwan University (SKKU)& Nagoya University (NU) Joint Symposium 2015
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Interactions between plasma-activated medium and cancer cells Invited International conference
H. Tanaka, and M. Hori
Bioplasmas and Plasmas with Liquids Conference
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プラズマ医療領域の創成と進展「大気圧プラズマによるがん治療」 Invited
田中 宏昌、水野 正明、豊國 伸哉、丸山 彰一、小寺 泰弘、足立 哲夫、寺崎 浩子、吉川 史隆、堀 勝
第68回日本酸化ストレス学会 2015.6.12
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低温プラズマの応用～プラズマ活性溶液の医療・農業・水産業への展開 Invited
田中 宏昌、水野 正明、吉川 史隆、堀 勝
幸田町企業立地マスタープラン推進委員会 2015.3.7
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がん治療に向けたプラズマ照射溶液の研究開発 Invited
田中 宏昌、水野 正明、豊國 伸哉、丸山 彰一、小寺 泰弘、足立 哲夫、寺崎 浩子、吉川 史隆、堀 勝
“未来へのバイオ技術勉強会” プラズマで拓くライフイノベーション 2015.2.5
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プラズマ活性溶液：作用機序解明と臨床応用・産業化を目指して
田中 宏昌,水野 正明,豊國 伸哉,丸山 彰一,小寺 泰弘,吉川 史隆,堀 勝
第19回九州拠点医工連携ゼミ
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大気圧プラズマを用いたがん研究に向けた基礎研究
田中 宏昌,水野 正明,豊國 伸哉,丸山 彰一,小寺 泰弘,吉川 史隆,堀 勝
第26回腎とフリーラジカル研究会
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INTRACELLULAR MOLECULAR MECHANISMS OF APOPTOSIS IN CANCER CELLS BY PLASMA-ACTIVATED MEDIUM International conference
Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Keigo Takeda, Kae Nakamura, Fumi Utsumi, Hiroaki Kajiyama, Hiroyuki Kano, Yasumasa Okazaki, Shinya Toyokuni, Shoichi Maruyama, Fumitaka Kikkawa, Masaru Hori
The 1st International Workshop on Plasma for Cancer Treatment
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Cancer therapy using atmospheric pressure plasma International conference
NU Tech @ NCSU
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システム生物学的プラズマ医療科学の幕開け Invited
田中 宏昌、堀 勝、吉川 史孝、水野 正明
平成２４年度 ものづくり交流フォーラム
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Selective Killing of Ovarian Cancer Cells through Induction of Apoptosis by a Nonequilibrium Atmospheric Pressure Plasma Invited International conference
H. Tanaka, S. Iseki, K. Nakamura, M. Hayashi, H. Kondo, H. Kajiyama, H. Kano, F. Kikkawa, M. Hori
The 15th Korea- Japan workshop for Advanced Plasma Process and Diagnostics
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Nonequiribrium Atmospheric Pressure Plasma (NEAPP): A Promising Tool for Medicine Invited International conference
H. Tanaka, S. Iseki, K. Nakamura, M. Hayashi, H. Kondo, H. Kajiyama, H. Kano, F. Kikkawa, M. Hori
International Workshop on Plasma Science for Bio-Application
KAKENHI (Grants-in-Aid for Scientific Research) 19
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The Development of Future Medicine Using Plasma-Activated Arginine Solution
Grant number：24K21539 2024.6 - 2027.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)
Authorship：Principal investigator
Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）
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Plasma-driven Sciences: Dynamics and transports of biochemically reactive species
Grant number：24H02254 2024.4 - 2029.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (A)
Authorship：Coinvestigator(s)
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Grant number：24H00202 2024.4 - 2027.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
Authorship：Principal investigator
Grant amount：\48360000 （ Direct Cost: \37200000 、 Indirect Cost：\11160000 ）
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大気圧プラズマが誘導する微小環境免疫トレランス解除機構の解明と新規細胞治療戦略
Grant number：23K08884 2023.4 - 2026.3
科学研究費助成事業 基盤研究(C)
中村 香江, 田中 宏昌, 芳川 修久
Authorship：Coinvestigator(s)
腹膜播種を伴う進行卵巣がんや再発例は治療抵抗性を獲得し難治性となる。がん免疫療法は、一部のがん種では治療成績を劇的に改善したが、腹膜播種に対する効果は限定的であり、免疫抑制的腫瘍微小環境に起因することが指摘されている。本研究において、大気圧プラズマを液体化したプラズマ活性溶液がCAR-T細胞療法の活性や持続性を向上させ、がん免疫療法の課題解決のための新規治療戦略となることを目指す。
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Plasma-modified peptides/proteins for multi-target anticancer treatment
Grant number：22H01212 2022.4 - 2027.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s)
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Plasma-modified peptides/proteins for multi-target anticancer treatment
Grant number：23K22483 2022.4 - 2027.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s)
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感染症拡大抑制に資する低温プラズマ及びプラズマ活性溶液の開発
Grant number：21K18616 2021.7 - 2024.3
科学研究費助成事業 挑戦的研究(萌芽)
田中 宏昌
Authorship：Principal investigator
Grant amount：\6500000 （ Direct Cost: \5000000 、 Indirect Cost：\1500000 ）
近年、低温でプラズマを発生する技術が進歩したことにより、生命科学への応用が盛んに行われている。WHOが2020年3月11日に新型コロナウイルス感染症はパンデミックであると宣言して以来、感染症対策は世界中で喫緊の課題となっている。本研究では、感染症拡大抑制に資する低温プラズマ及びプラズマ活性溶液の開発を目指す。具体的には豚コロナウイルスや新型コロナウイルスに対する低温プラズマ照射及びプラズマ活性溶液による不活化試験を行う。更に、ウイルスのエンベロープの構造の変化を調べることにより、エンベロープウイルスに対する低温プラズマ及びプラズマ活性溶液による不活化の分子機構を明らかにする。
一昨年度、ベルリサーチセンター小屋博士と共同で、BSL2で取り扱いが可能なヒトコロナウイルスOC43の実験系を立ち上げたり、受託解析によMild PALの豚コロナウイルス（PVDE）に対する不活化能と新型コロナウイルスSARS-Cov2デルタ株に対する不活化能を調べ、コロナウイルスを不活化するPALの条件を見出したが、昨年度は、更に、ペンタイプのプラズマ装置の実験系を立ち上げたり、PALの成分に関する知見を深めるための基礎的な実験を進めた。ペンタイプのプラズマ装置を使い、照射時間や照射距離を変えながらPALを作製し、pHや過酸化水素濃度、亜硝酸イオン濃度を計測し、どのようなパラメーターセットでどのような条件のPALが作製できるかの基礎的なデータを収集した。また、PALの成分解析の一環として、ESR、NMR、GC-MS、LC-MSを駆使して、これまでにPALの成分として同定されたピルビン酸、酢酸、ギ酸、グリオキシル酸、2,3-ジメチル酒石酸の反応生成メカニズムを明らかにし、Plasma Processes and Polymersに論文公表した。更に、完全密閉プラズマ活性溶液作製装置を用い、アルゴン雰囲気下で、フィードガスとしてアルゴンガス100%、アルゴンガス90%＋酸素ガス10%、アルゴンガス90%+窒素ガス10%、アルゴンガス80%+酸素ガス10%+窒素ガス10%の酸素の条件下でPALを作製し、pHや過酸化水素濃度、亜硝酸イオン濃度を計測し、成分がどのように変化するのかの解析を進めた。
BSL2で取り扱い可能なヒトコロナウイルスOC43の実験系が一昨年度立ち上げられ、昨年度はPALの成分やその反応機構に関する研究が躍進したため、コロナ不活化のためのPALの開発に向けて大きく前進し、おおむね順調に進展していると言える。
昨年度、PALの成分に関する知見が更に蓄積されたが、亜硝酸イオン濃度が高いことがコロナウイルスの不活化能上昇と関係しているかどうかを調べるために、引き続き、完全閉鎖型のプラズマ活性溶液作製装置を用い、アルゴン雰囲気化でプラズマ活性溶液を作製し、窒素ガス添加によるPALのコロナウイルス不活化能の違いを調べたり、また、アルゴン雰囲気化で、窒素ガスや酸素ガスを 様々な混合比で添加することにより、コロナウイルス不活化能におけるPALの最適化を試みる。また最終年度であるため、これらの成果をまとめて論文を投稿したいと考えている。 -
Spatiotemporal analysis of aqueous reaction field of plasma-generated free radicals
Grant number：21H04451 2021.4 - 2024.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
Authorship：Coinvestigator(s)
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Grant number：21H01072 2021.4 - 2024.3
科学研究費助成事業 基盤研究(B)
田中 宏昌
Authorship：Principal investigator
Grant amount：\17420000 （ Direct Cost: \13400000 、 Indirect Cost：\4020000 ）
近年、低温プラズマのライフサイエンスへの応用研究が活発に進められている。我々は低温プラズマによるがん治療研究を活発に進め、プラズマ照射した溶液による抗腫瘍効果を発見し、この溶液をプラズマ活性溶液と名付けた。その後、プラズマ活性溶液による細胞死の分子機構が世界中で研究され、様々な既知のシグナル伝達経路の関与が明らかになってきた。本研究では、マイクロアレイ解析により未知のプラズマ応答遺伝子を探索し、定量リアルタイムPCR（qRT-PCR）法により検証する。更に質量分析に基づくプロテオミクス解析などを行うことにより低温プラズマやプラズマ活性溶液が活性化する新規シグナル伝達経路を探索する。
これまで、脳腫瘍培養細胞U251SPを主な研究対象としてプラズマ活性培養液（PAM）やプラズマ活性乳酸リンゲル液（PAL）による細胞死の細胞内分子機構の研究を進めてきたが、今年度はプラズマ活性溶液による選択的細胞死のモデルとして、乳がん細胞MCF7と乳腺上皮細胞MCF10Aを主な研究対象として、その細胞内分子機構の研究を進めた。
まずは、大気雰囲気下で8mLの乳酸リンゲル液を照射距離3mm照射時間5分でプラズマ照射したPALの様々な希釈系列を用意し、MCF10A細胞に対してMCF7細胞を選択的に殺傷するPALの条件を見出した。更に、アルゴン雰囲気下で、フィードガスの条件をアルゴン100%、アルゴン90％＋窒素10％、アルゴン90％＋酸素10％、アルゴン80％＋窒素10％＋酸素10％で作成したPALを用意し、各種希釈系列で選択的殺傷効果を示す条件を探索したところ全ての条件で選択的殺傷効果を示す希釈倍率が存在したが、窒素を加えたPALでは選択的殺傷効果のレンジが拡がることが分かった。以上の結果から、酸素が加わることで、PALの強さを制御し、窒素が加わることで更に選択制を制御しうることが分かった。また、これらのPALの過酸化水素濃度、亜硝酸イオン濃度、pHを測定した結果、酸素が加わることで、過酸化水素の濃度が上昇し、窒素が加わることで、亜硝酸イオンの濃度が上昇するが、酸素と窒素が両方加わることで、過酸化水素濃度と亜硝酸イオン濃度は更に上昇することが分かった。
最後に、選択的殺傷効果を示す条件のPALに加え、MCF7とMCF10Aの両方を殺傷する条件のPAL、両方に対して影響を与えない条件のPALを用意し、マイクロアレイによる網羅的遺伝子発現解析を行った。その結果、各条件で未照射の乳酸リンゲル液に比べPAL投与により2倍以上発現量が上昇する遺伝子がいくつか同定された。
今年度は、PALの新たな成分を同定した論文、これまで同定していたPALの成分であるピルビン酸、ギ酸、酢酸、グリオキシル酸、2,3-ジメチル酒石酸が生成される反応機構をまとめた論文、PALによる遺伝毒性を評価した論文など10報の論文が学術雑誌に公表され、当初の計画以上に進展していると言える。また、Free Radical ResearchにこれまでのPALの成果をまとめたreview論文を公表することにより本分野における我々のプレゼンスを世界にアピールすることができ、当初の計画以上に進展していると言える。
今年度のマイクロアレイの結果同定された遺伝子のうちで、選択的殺傷効果を示す条件のPALにおいて、MCF７のみで遺伝子発現が上昇あるいは下降するする遺伝子やMCF10Aのみで遺伝子発現が上昇あるいは下降する遺伝子に着目し、リアルタイムPCR法によりマイクロアレイ実験の妥当性を検証すると共に、PAL投与後の遺伝子発現のダイナミクスを調べる。例えば、選択的殺傷効果を示す条件のPALでMCF7のみで遺伝子発現が上昇する遺伝子としては細胞死を誘導するシグナル伝達経路に関する遺伝子が含まれると考えられることから、これらの遺伝子を明らかにすることによりMCF10Aに対してMCF7を選択的に殺傷するシグナル伝達機構を解明できると考えている。また、選択的殺傷効果を示す条件のPALにおけるMCF7細胞とMCF10A細胞において細胞内ROSを検出したり、アポトーシスを起こしている細胞の割合を調べたり、DNAダメージを検出することにより、多くのプラズマ細胞応答として惹起される酸化ストレス依存的な細胞死の寄与を評価する。更にはEcto-CRT（細胞膜表面のカルレティキュリンタンパク質）のレベルを評価することにより、いくつかのプラズマ細胞応答例として注目されている免疫原性細胞死の寄与を評価する。以上から、PALによる選択的殺傷効果の作用機序を解明したいと考えている。 -
Grant number：20K09640 2020.4 - 2023.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Nakamura Kae
Authorship：Coinvestigator(s)
1It has been demonstrated that immune cells whose character was changed at the peritoneal metastasis microenvironment could contribute to cancer progression in gynecologic malignancy. In this study, we investigated the activation of anti-tumor immune response in tumor microenvironment treated with plasma-activated solution, liquified gaseous of an atmospheric pressure plasma, having an effect of anti-tumor and cell activation. The results showed 1) increased M1-type macrophage, having an anti-tumor activity, infiltration in the peritoneal metastasis, 2) cancellation of the immunosuppression of T cells induced by patient-derived cancerous ascites, and 3) activation of T cell immunosuppressed by TGF-β1.
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大気圧プラズマのケロイド・肥厚性瘢痕に与える影響に関する基礎的研究
Grant number：19K10025 2019.4 - 2024.3
科学研究費助成事業 基盤研究(C)
亀井 譲, 田中 宏昌, 蛯沢 克己, 神戸 未来, 高成 啓介
Authorship：Coinvestigator(s)
ケロイドや肥厚性瘢痕は、拘縮・疼痛や醜状など患者の負担は大きく、また治療難渋する症例も少なくなく、新たな治療法の開発が期待されている。近年、大気圧プラズマ研究の進歩により、細胞増殖・分化などに対する様々な影響が報告され始めた。その中で、筋線維芽細胞への分化やその増殖を、大気圧プラズマが制御できないか、という着想に至った。本研究では、①大気圧プラズマのラジカル分布パターン解析、②大気圧プラズマの皮膚創傷治癒関連細胞に与える影響の解析、③ケロイド・肥厚性瘢痕動物モデルで、大気圧プラズマによる発症・進展予防や治療の効果検討を行い、大気圧プラズマによるケロイド・肥厚性瘢痕に与える影響について検討する。
昨年までと同様、細胞レベルでのプラズマ活性化乳酸リンゲル液の肥厚性瘢痕・ケロイドに対する影響を調べるため、ケロイド・肥厚性瘢痕組織において重要な挙動を示す線維芽細胞に引き続き焦点を当てた。市販のヒト正常真皮由来およびケロイド由来線維芽細胞の比較では、両細胞とも処理用のプラズマ活性化乳酸リンゲル液を希釈するに従い増殖が亢進し、1/32倍以下の濃度では一定となる結果を得ていた。Covid-19の影響が重なる期間でもあり、現状得られたサンプルでは、両群間に統計劇的有意差は認めるには至っていない。もう少し多くのドナーで検証が必要と考えている。
昨年度までに難渋していたケロイド・肥厚性瘢痕動物モデルの作成をに関しては、本年度もさまざまなモデルを試行錯誤したが、正常皮膚ですら3ヶ月正着を維持する事ができなかった。そのため、ケロイド・肥厚性瘢痕の移植はできない状態である。
プラズマ活性化乳酸リンゲル液の生体に与える影響を検討するため、複数の倍率で希釈したプラズマ活性化乳酸リンゲル液を正常皮膚へ塗布し、解析を行った。皮膚所見では、原液から1000倍希釈液まで発赤やびらんなどの皮膚障害を認めなかった。塗布部の皮膚HE染色標本においても、マクロの所見と同様に炎症性細胞浸潤を認めなかった。また、各マウスの脾蔵・肝臓・腎臓を採取し、HE染色標本を作製したところ、各濃度での異常所見を認めなかった。さらに各マウスの採血を行い、血清を分離してサンプルを冷凍保存した。研究チームの医ミーティングで、プラズマ活性化リンゲル液暴露による反応として、酸化ストレスプロファイルの変化を解析すべきとの意見がでてきた。
本研究で最も重要な正常線維芽細胞とケロイド・肥厚性由来線維芽細胞（または筋線維芽細胞）間で、プラズマ活性化乳酸リンゲル液暴露による細胞増殖の有意差が出ていない。また、プラズマ活性化乳酸リンゲル液暴露を行う動物モデルの作成では壁に当たっているため。
プラズマ活性化乳酸リンゲル液暴露の条件として、濃度だけでなく、暴露時間に関しても複数の条件で試行を行い、条件の至適化を行う。
動物モデルに関しては、今まで通り難渋する事が予想されるが、諸家らの報告をさらに施行する予定である。 -
Grant number：18K03599 2018.4 - 2021.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Hiromasa Tanaka
Authorship：Principal investigator
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
Low-temperature plasma has been studied for medical applications. We had focused on the plasma cancer treatments, and we have previously invented plasma-activated solutions. In this study, we used plasma-activated medium (PAM) and plasma-activated Ringer’s lactate solution (PAL) for plasma cancer treatments. We found that PAM induced oxidative stress-dependent cell death on glioblastoma brain tumor cells while PAL induced oxidative stress-independent cell death on glioblastoma cells. These results suggest that plasma-activated solutions might be useful for cancer drug resistant cancer therapy.
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Construction of carbon nanowall sheet edge electronics and differentiation induction control of single cell
Grant number：15H02032 2015.4 - 2018.3
Hori Masaru
Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)
In order to cultivate biotechnology devices and plasma bioelectronics that can control adhesion, morphology and differentiation induction of cells by systematic elucidation interaction between electronic properties developed from nanosheet-edges in carbon nanowall (CNW) and cells, the effects of superimposed electrical stimulation on the CNW scaffold on the proliferation / differentiation (ossification) of osteoblasts were elucidated. Proliferation promotion and suppression of ossification were specifically confirmed only when the electrical stimulation at the frequency of 10 Hz was superimposed. Furthermore, the dependence on wall density and the formation of cell clumps without ossification were also found. These suggest changes in cell proliferation and differentiation due to the synergy between the sheet edge on the CNW surface and electrical stimulation, and establishment of new cell control technology in various regenerative medicine is expected.
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Controling cell death, survival, and growth by plasma-activated solutions
Grant number：15K13390 2015.4 - 2017.3
Tanaka Hiromasa
Authorship：Principal investigator
Grant amount：\3900000 （ Direct Cost: \3000000 、 Indirect Cost：\900000 ）
We have previously developed plasma-activated medium (PAM) that is plasma-treated medium for cancer treatments. In this study, we collaborated with department of obstetrics and gynecology and department of gastrointestinal surgery, and have developed plasma-activated Ringer’s lactate solution to treat with ovarian, gastric, and pancreatic cancers which are peritoneally disseminated. In addition, we collaborated with biochemical engineering lab, and found that PAM selectively eliminates undifferentiated human induced pluripotent stem cells. Thus, plasma-activated medium have broadened the applications of plasmas in medicine.
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Cancer treatments using plasma activated liquids and elucidating the mechanisms
Grant number：15H05430 2015.4 - 2017.3
Tanaka Hiromasa
Authorship：Principal investigator
Grant amount：\16250000 （ Direct Cost: \12500000 、 Indirect Cost：\3750000 ）
Recently, medical applications using non-thermal atmospheric pressure plasmas have attracted attention in the field of medicine. We have developed non-thermal atmospheric pressure plasma sources, and applied for cancer therapy. We found anti-tumor effects by plasma treated medium, which we termed “plasma-activated medium or PAM”. In this study, we further developed plasma-activated Ringer’s lactate solution or PAL, and we found that plasma-treated L-sodium lactate is an anti-tumor factor in the PAL. Based on these results, we proposed that PAL is promising as a novel chemotherapy for cancers such as peritoneally disseminated cancers.
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Real-time in situ measurements of free radicals during Plasma sterilization
Grant number：26286071 2014.4 - 2017.3
Ishikawa Kenji
Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)
The low-temperature plasma sterilization have advantages for applications. However, complexity of plasma processes arises from the involvement of a myriad of species including: electrons, ions, radicals, and photons. Such plasma components are needed to be measured and analyzed for fine-tuning the process. To determine the best practice for the sterilization, plasma diagnostics were conducted on clarifying the relationship between the control parameters and the plasma parameters.
Penicillium digitatum spores, which causes green mold on citrus, are inactivated by contribution of extracellular reactive oxygen species (ROS). The stable free radical as semiquinone in the spores decreases during oxygen atom irradiation observed using real time in situ electron spin resonance (ESR). The plasma electrical discharge induce metabolic modification. Also, intracellular metabolites induce the inactivation of spores. These understanding provides the development of plasma sources. -
Elucidating the intracellular molecular mechanisms of cell death of cancer cells by atmospheric pressure plasma
Grant number：25870307 2013.4 - 2015.3
TANAKA Hiromasa
Authorship：Principal investigator
Grant amount：\4290000 （ Direct Cost: \3300000 、 Indirect Cost：\990000 ）
We found that plasma-irradiated medium induced apoptosis on glioblastoma brain tumor cells, and termed this medium plasma-activated medium (PAM). PAM down-regulated activities of signaling molecules in the survival and proliferation signaling network and induced reactive oxygen species (ROS) on glioblastoma to induce apoptosis. The PAM projects have brought us many collaborative works that include collaborations with departments of Obsterics and gynecology, Gastrointestinal surgery for treatments of peritoneal dissemination of ovarian cancers and gastric cancers, and Ophthalmology for treatments of age-related macular degeneration. We have published 10 papers and applied for 9 patents.
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Diagnostic analyses of dynamical interaction of plasma and surface in plasma medicine
Grant number：24108002 2012.6 - 2017.3
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
HORI Masaru
Authorship：Collaborating Investigator(s) (not designated on Grant-in-Aid)
An innovative approach for producing reactive oxygen and nitrogen species is the use of non-thermal atmospheric pressure plasma. The technique has been applied in a wide variety of fields ranging from the micro-fabrication of electric devices to the treatment of disease. Although non-thermal atmospheric pressure plasmas have been shown to be clinically beneficial for wound healing, blood coagulation, and cancer treatment, the underlying molecular mechanisms are poorly understood. Our researches obtained the current progress in plasma medicine, with a particular emphasis on plasma-activated medium (PAM), which is a solution that is irradiated with a plasma and has broadened the applications of plasmas in medicine.
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Systematization and development of clinical applications for plasma medicine based on scientific infrastructure
Grant number：24108008 2012.6 - 2017.3
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Kikkawa Fumitaka
Authorship：Other
Non-thermal plasma has been focused on as a novel medical practice. There have been a number of reports showing the effect of non-thermal plasma on cell death of various cancers. We have succeeded in selective killing of ovarian cancer and glioblastoma brain tumor cells, which are difficult to achieve complete remission under the present therapies, using not only directly but also indirectly plasma referred to as plasma-activated liquids. We have also elucidated that the effects and mechanisms of non-thermal plasma on biological systems using mesothelioma. We have demonstrated that plasma-activated liquids might be more useful for advanced cancers with metastasis and micro-dissemination. On the other hand, for developing medical applications of non-thermal plasma, we have achieved a certain result for regenerative medicine using human adipose tissue-derived stromal cells we established.
These discoveries have led to the use of non-thermal plasma for alternative clinical applications.
Industrial property rights 3
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抗腫瘍水溶液および抗癌剤とそれらの製造方法
堀 勝,水野 正明,吉川 史隆,梶山 広明,中村 香江,内海 史,石川 健治,竹田 圭吾,田中 宏昌,加納 浩之
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プラズマ溶液とその製造方法
堀 勝,水野 正明,吉川 史隆,梶山 広明,中村 香江,石川 健治,田中 宏昌,加納 浩之
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卵巣癌治療装置
堀 勝,近藤 博基,竹田 圭吾,田中 宏昌,吉川 史隆,梶山 広明,中村 香江,加納 浩之
Teaching Experience (On-campus) 2
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大学院特別講義 ナノプロセス工学特論 「分子生物学の基礎」
2019
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大学院特別講義 ナノプロセス工学特論 「分子生物学の基礎」
2016
Teaching Experience (Off-campus) 5
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大学院特別講義 ～プラズマ医療からプラズマファーマシーへ～
2022.9 （Gifu Pharmaceutical University）
Level：Postgraduate Country：Japan
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大阪市立大学医工・生命工学教育研究センター第6回セミナー「プラズマ医療科学概論」
2019.11 （Osaka City University）
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大学院集中講義 理学特別講義A10「プラズマの生物への応用」
2016.9 （Kumamoto University）
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夏季実習セミナー（II） 「ドライプロセスの基礎と薄膜作製（ドライプロセスと医療）」
2016.8 （Chiba Institute of Technology）
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大学院特別講義 「プラズマ医療科学特論」
2016.5 （Gifu Pharmaceutical University）
Social Contribution 1
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プラズマ技術で養殖魚の成長促進
Role(s)：Appearance, Media coverage, Informant
NHK「おはよう東海」 2016.12
Media Coverage 1
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プラズマ技術で養殖魚の成長促進 TV or radio program
NHK NHK「おはよう東海」 2016.12
Academic Activities 1
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ISPlasma2021/IC-PLANTS2021 International contribution
Role(s)：Panel moderator, session chair, etc., Review, evaluation, Peer review
2021.3