社会保険中京病院整形外科

2004.4 - 2010.3

社会保険中京病院嘱託研修医

2002.5 - 2004.3

Are Generative Pretrained Transformer 4 Responses to Developmental Dysplasia of the Hip Clinical Scenarios Universal? An International Review Reviewed International coauthorship

Luo, ST; Canavese, F; Aroojis, A; Andreacchio, A; Anticevic, D; Bouchard, M; Castaneda, P; De Rosa, V; Fiogbe, MA; Frick, SL; Hui, JH; Johari, AN; Loro, A; Lyu, XM; Matsushita, M; Omeroglu, H; Roye, DP; Shah, MM; Yong, BC; Li, LY

JOURNAL OF PEDIATRIC ORTHOPAEDICS   Vol. 44 ( 6 ) page： e504 - e511   2024.7

Neglected Sprengel's deformity in an 80-year-old female cadaver: a case report Reviewed

Otsuka, S; Tamaki, Y; Matsushita, M; Hatayama, N; Naito, M

JOURNAL OF MEDICAL CASE REPORTS   Vol. 18 ( 1 ) page： 211   2024.4

Long-term oral meclozine administration improves survival rate and spinal canal stenosis during postnatal growth in a mouse model of achondroplasia in both sexes Reviewed

Funahashi, H; Matsushita, M; Esaki, R; Mishima, K; Ohkawara, B; Kamiya, Y; Takegami, Y; Ohno, K; Kitoh, H; Imagama, S

JBMR PLUS   Vol. 8 ( 4 ) page： ziae018   2024.3

Quality of life in adult patients with developmental dysplasia of the hip who were treated for hip dislocation during childhood. Reviewed

Sawamura K, Kitoh H, Matsushita M, Mishima K, Kamiya Y, Imagama S

Journal of pediatric orthopedics. Part B     2024.2

Generalized Epileptic Seizures in Fibrodysplasia Ossificans Progressiva Harboring a Recurrent Heterozygous Variant of the ACVR1 Gene (R206H). Reviewed

Mishima K, Kitoh H, Shiraki A, Sawamura K, Kamiya Y, Matsushita M, Imagama S

Case reports in genetics   Vol. 2024   page： 9569275   2024

A 14-day repeated oral administration of meclizine in child patients with achondroplasia to evaluate safety and pharmacokinetics

Matsushita, M; Mishima, K; Kamiya, Y; Sawamura, K; Kitoh, H; Imagama, S

JOURNAL OF BONE AND MINERAL RESEARCH   Vol. 38   page： 373 - 373   2023.11

Phase 1b study on the repurposing of meclizine hydrochloride for children with achondroplasia Reviewed

Matsushita, M; Kitoh, H; Mishima, K; Kamiya, Y; Kato, D; Takemoto, G; Sawamura, K; Ueno, S; Yasuhiro, N; Nishida, K; Imagama, S

PLOS ONE   Vol. 18 ( 7 ) page： e0283425   2023.7

Prognostic value of bone resorption pattern in the anterior portion of the femoral head in Legg-Calve-Perthes disease Reviewed

Mishima, K; Kamiya, Y; Matsushita, M; Imagama, S

JOURNAL OF CHILDRENS ORTHOPAEDICS   Vol. 17 ( 3 ) page： 197 - 204   2023.6

Activated FGFR3 suppresses bone regeneration and bone mineralization in an ovariectomized mouse model Reviewed

Kawashima, I; Matsushita, M; Mishima, K; Kamiya, Y; Osawa, Y; Ohkawara, B; Ohno, K; Kitoh, H; Imagama, S

BMC MUSCULOSKELETAL DISORDERS   Vol. 24 ( 1 ) page： 200   2023.3

Guided growth for coronal lower limb deformities in skeletal dysplasia Reviewed

Kitoh, H; Kamiya, Y; Mishima, K; Matsushita, M; Kaneko, H; Kitamura, A; Sawamura, K; Matsuyama, S

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B   Vol. 32 ( 2 ) page： 157 - 164   2023.3

Acute osteomyelitis of the patella due to <i>Pseudomonas aeruginosa</i> in an immunocompetent child: A case report Reviewed

Kamiya, Y; Mishima, K; Tanaka, T; Sawamura, K; Matsushita, M; Imagama, S

MEDICINE   Vol. 102 ( 7 ) page： e33012   2023.2

Meclozine ameliorates bone mineralization and growth plate structure in a mouse model of X-linked hypophosphatemia Reviewed

Kamiya, Y; Matsushita, M; Mishima, K; Ohkawara, B; Michigami, T; Imagama, S; Ohno, K; Kitoh, H

EXPERIMENTAL AND THERAPEUTIC MEDICINE   Vol. 25 ( 1 ) page： 39   2023.1

Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice Reviewed

Kato, D; Matsushita, M; Takegami, Y; Mishima, K; Kamiya, N; Osawa, Y; Imagama, S; Kitoh, H

CALCIFIED TISSUE INTERNATIONAL   Vol. 111 ( 6 ) page： 622 - 633   2022.12

A cross-sectional nationwide survey of osteosclerotic skeletal dysplasias in Japan Reviewed

Sawamura, K; Mishima, K; Matsushita, M; Kamiya, Y; Kitoh, H

JOURNAL OF ORTHOPAEDIC SCIENCE   Vol. 27 ( 5 ) page： 1139 - 1142   2022.9

Bypass of Epiphyseal Fragmentation Following Early Salter Innominate Osteotomy and Its Clinical Relevance in Legg-Calve-Perthes Disease Reviewed

Mishima, K; Kamiya, Y; Matsushita, M; Imagama, S; Kitoh, H

JOURNAL OF PEDIATRIC ORTHOPAEDICS   Vol. 42 ( 5 ) page： 239 - 245   2022.5

Predictive ability of inflammatory markers and laboratory parameters in Legg-Calve-Perthes disease A single-center retrospective comparative study

Mishima, K; Kamiya, Y; Matsushita, M; Imagama, S; Kitoh, H

MEDICINE   Vol. 101 ( 11 )   2022.3

Disease-specific complications and multidisciplinary interventions in achondroplasia

Kitoh, H; Matsushita, M; Mishima, K; Kamiya, Y; Sawamura, K

JOURNAL OF BONE AND MINERAL METABOLISM   Vol. 40 ( 2 ) page： 189 - 195   2022.3

Meclozine ameliorates skeletal muscle pathology and increases muscle forces in<i> mdx</i> mice

Kawamura, Y; Hida, T; Ohkawara, B; Matsushita, M; Kobayashi, T; Ishizuka, S; Hiraiwa, H; Tanaka, S; Tsushima, M; Nakashima, H; Ito, K; Imagama, S; Ito, M; Masuda, A; Ishiguro, N; Ohno, K

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   Vol. 592   page： 87 - 92   2022.2

Meclozine Attenuates the MARK Pathway in Mammalian Chondrocytes and Ameliorates FGF2-Induced Bone Hyperossification in Larval Zebrafish

Takemoto, G; Matsushita, M; Okamoto, T; Ito, T; Matsuura, Y; Takashima, C; Chen-Yoshikawa, TF; Ebi, H; Imagama, S; Kitoh, H; Ohno, K; Hosono, Y

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY   Vol. 9   page： 694018   2022.1

Inconvenience and adaptation in Japanese adult achondroplasia and hypochondroplasia: A cross-sectional study

Ajimi Akiko, Matsushita Masaki, Mishima Kenichi, Haga Nobuhiko, Fujiwara Sayaka, Ozono Keiichi, Kubota Takuo, Kitaoka Taichi, Imagama Shiro, Kitoh Hiroshi

CLINICAL PEDIATRIC ENDOCRINOLOGY   Vol. 31 ( 1 ) page： 18 - 24   2022.1

Inconvenience and adaptation in Japanese adult achondroplasia and hypochondroplasia: A cross-sectional study.

Ajimi A, Matsushita M, Mishima K, Haga N, Fujiwara S, Ozono K, Kubota T, Kitaoka T, Imagama S, Kitoh H

Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology   Vol. 31 ( 1 ) page： 18 - 24   2022

Asfotase alfa has a limited effect in improving the bowed limbs in perinatal benign hypophosphatasia: A case report

Matsushita, M; Mishima, K; Nagata, T; Kamiya, Y; Imagama, S; Kitoh, H

CLINICAL PEDIATRIC ENDOCRINOLOGY   Vol. 30 ( 1 ) page： 53 - 56   2021.1

Health-related Quality of Life in Adult Patients with Multiple Epiphyseal Dysplasia and Spondyloepiphyseal Dysplasia.

Matsushita M, Mishima K, Kamiya Y, Haga N, Fujiwara S, Ozono K, Kubota T, Kitaoka T, Imagama S, Kitoh H

Progress in rehabilitation medicine   Vol. 6   page： 20210048   2021

Effect of periosteal resection on longitudinal bone growth in a mouse model of achondroplasia

Kaneko, S; Matsushita, M; Mishima, K; Takegami, Y; Imagama, S; Kitoh, H

BONE REPORTS   Vol. 13   page： 100708   2020.12

Legg-Calve-Perthes disease in a patient with Bardet-Biedl syndrome: A case report of a novel <i>MKKS/BBS6</i> mutation

Mishima, K; Fujita, A; Mizuno, S; Matsushita, M; Nagata, T; Kamiya, Y; Miyake, N; Matsumoto, N; Imagama, S; Kitoh, H

CLINICAL CASE REPORTS   Vol. 8 ( 12 ) page： 3109 - 3114   2020.12

Comparison of surgical and nonsurgical containment methods for patients with Legg-Calve-Perthes disease of the onset ages between 6.0 and 8.0 years: Salter osteotomy versus a non-weight-bearing hip flexion-abduction brace

Kaneko, H; Kitoh, H; Mishima, K; Matsushita, M; Hattori, T; Noritake, K; Ishiguro, N; Yoshihashi, Y

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B   Vol. 29 ( 6 ) page： 542 - 549   2020.11

A retrospective comparative study of corrective osteotomy for tibial deformities with the multiaxial correction fixator and the circular fixator.

Matsushita M, Kitoh H, Mishima K, Nagata T, Kamiya Y, Kaneko H, Hattori T, Ishiguro N

Journal of clinical orthopaedics and trauma   Vol. 11 ( Suppl 4 ) page： S621 - S625   2020.7

Lower limb pain following allogeneic hematopoietic stem cell transplantation in Japanese children

Mishima, K; Kitoh, H; Matsushita, M; Nagata, T; Kamiya, Y; Takahashi, Y; Ishiguro, N

JOURNAL OF ORTHOPAEDIC SCIENCE   Vol. 25 ( 4 ) page： 682 - 687   2020.7

Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

Kitoh, H; Matsushita, M; Mishima, K; Nagata, T; Kamiya, Y; Ueda, K; Kuwatsuka, Y; Morikawa, H; Nakai, Y; Ishiguro, N

PLOS ONE   Vol. 15 ( 4 ) page： e0229639   2020.4

Severe achondroplasia due to two de novo variants in the transmembrane domain of <i>FGFR3</i> on the same allele: A case report

Nagata, T; Matsushita, M; Mishima, K; Kamiya, Y; Kato, K; Toyama, M; Ogi, T; Ishiguro, N; Kitoh, H

MOLECULAR GENETICS & GENOMIC MEDICINE   Vol. 8 ( 3 ) page： e1148   2020.3

Impact of fracture characteristics and disease-specific complications on health-related quality of life in osteogenesis imperfecta

Matsushita, M; Mishima, K; Yamashita, S; Haga, N; Fujiwara, S; Ozono, K; Kubota, T; Kitaoka, T; Ishiguro, N; Kitoh, H

JOURNAL OF BONE AND MINERAL METABOLISM   Vol. 38 ( 1 ) page： 109 - 116   2020.1

Physical, Mental, and Social Problems of Adolescent and Adult Patients with Achondroplasia

Matsushita, M; Kitoh, H; Mishima, K; Yamashita, S; Haga, N; Fujiwara, S; Ozono, K; Kubota, T; Kitaoka, T; Ishiguro, N

CALCIFIED TISSUE INTERNATIONAL   Vol. 104 ( 4 ) page： 364 - 372   2019.4

Early radiographic risk factors for rigid relapse in idiopathic clubfoot treated with the Ponseti method.

Mishima K, Kitoh H, Matsushita M, Sugiura H, Hasegawa S, Kitamura A, Nishida Y, Ishiguro N

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons   Vol. 24 ( 6 ) page： 509 - 513   2018.12

Changes in the range of motion of the lower limb joints during extensive tibial lengthening in achondroplasia

Kadono Izumi, Kitoh Hiroshi, Mishima Kenichi, Matsushita Masaki, Sato Koji, Kako Masato, Ishiguro Naoki

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B   Vol. 27 ( 6 ) page： 535 - 540   2018.11

A Mouse Distraction Osteogenesis Model

Fujio Masahito, Osawa Yusuke, Matsushita Masaki, Ogisu Kota, Tsuchiya Shuhei, Kitoh Hiroshi, Hibi Hideharu

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS   ( 141 )   2018.11

Long term health-related quality of life in patients with achondroplasia and hypochondroplasia

Matsushita, M; Kitoh, H; Mishima, K; Ishiguro, N; Fujiwara, S; Haga, N; Kitaoka, T; Kubota, T; Ozono, K

JOURNAL OF BONE AND MINERAL RESEARCH   Vol. 33   page： 300 - 301   2018.11

Activated FGFR3 prevents subchondral bone sclerosis during the development of osteoarthritis in transgenic mice with achondroplasia.

Okura T, Matsushita M, Mishima K, Esaki R, Seki T, Ishiguro N, Kitoh H

Journal of orthopaedic research : official publication of the Orthopaedic Research Society   Vol. 36 ( 1 ) page： 300 - 308   2018.1

Chronic lateral epiphyseal separation of the proximal tibia causes late-onset tibia vara.

Hasegawa S, Kitoh H, Matsushita M, Mishima K, Kadono I, Sugiura H, Kitamura A, Ishiguro N

Journal of pediatric orthopedics. Part B   Vol. 27 ( 1 ) page： 31 - 34   2018.1

A Novel Heterozygous Mutation in the T-box Protein 4 Gene in an Adult Case of Small Patella Syndrome.

Oda T, Matsushita M, Ono Y, Kitoh H, Sakai T

Journal of orthopaedic case reports   Vol. 8 ( 1 ) page： 85 - 88   2018.1

Extensive Bone Lengthening for a Patient with Linear Morphea.

Mishima K, Kitoh H, Matsushita M, Nagata T, Kamiya Y, Ishiguro N

Case reports in orthopedics   Vol. 2018   page： 4535804   2018

Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis

Osawa Yusuke, Matsushita Masaki, Hasegawa Sachi, Esaki Ryusaku, Fujio Masahito, Ohkawara Bisei, Ishiguro Naoki, Ohno Kinji, Kitoh Hiroshi

BONE   Vol. 105   page： 42 - 49   2017.12

Activated FGFR3 Prevents Subchondral Bone Sclerosis During the Development of Osteoarthritis in Transgenic Mice with Achondroplasia.

Okura, T; Matsushita, M; Mishima, K; Seki, T; Ishiguro, N; Kitoh, H

JOURNAL OF BONE AND MINERAL RESEARCH   Vol. 32   page： S201 - S201   2017.12

Clinical dosage of meclozine promotes longitudinal bone growth, bone volume, and trabecular bone quality in transgenic mice with achondroplasia

Matsushita Masaki, Esaki Ryusaku, Mishima Kenichi, Ishiguro Naoki, Ohno Kinji, Kitoh Hiroshi

SCIENTIFIC REPORTS   Vol. 7 ( 1 ) page： 7371   2017.8

Percutaneous pinning after prolonged skeletal traction with the hip in a flexed position for unstable slipped capital femoral epiphysis A case series of 11 patients

Matsushita Masaki, Mishima Kenichi, Iwata Kohji, Hattori Tadashi, Ishiguro Naoki, Kitoh Hiroshi

MEDICINE   Vol. 96 ( 19 ) page： e6662   2017.5

Is the timing of surgery associated with avascular necrosis after unstable slipped capital femoral epiphysis? A multicenter study.

Kohno Yusuke, Nakashima Yasuharu, Kitano Toshio, Irie Taichi, Kita Atsushi, Nakamura Tomoyuki, Endo Hirosuke, Fujii Yosuke, Kuroda Takayuki, Mitani Shigeru, Kitoh Hiroshi, Matsushita Masaki, Hattori Tadashi, Iwata Koji, Iwamoto Yukihide

JOURNAL OF ORTHOPAEDIC SCIENCE   Vol. 22 ( 1 ) page： 112 - 115   2017.1

Maternal administration of meclozine for the treatment of foramen magnum stenosis in transgenic mice with achondroplasia

Matsushita Masaki, Mishima Kenichi, Esaki Ryusaku, Ishiguro Naoki, Ohno Kinji, Kitoh Hiroshi

JOURNAL OF NEUROSURGERY-PEDIATRICS   Vol. 19 ( 1 ) page： 91 - 95   2017.1

Maternal administration of meclozine for the treatment of foramen magnum stenosis in transgenic mice with achondroplasia

Matsushita M, Mishima K, Esaki R, Ishiguro N, Ohno K, Kitoh H

J Neurosurg Pediatr   Vol. 19   page： 91-95   2017

[Risk factors for rebleeding and risk-based follow-up of obscure gastrointestinal bleeding after its initial diagnosis].

Uchida G, Nakamura M, Watanabe O, Yamamura T, Matsushita M, Ishikawa T, Furukawa K, Funasaka K, Ohno E, Kawashima H, Miyahara R, Goto H, Hirooka Y

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology   Vol. 114 ( 10 ) page： 1819 - 1829   2017

Clinical Results and Complications of Lower Limb Lengthening for Fibular Hemimelia: A Report of Eight Cases. Invited Reviewed

Mishima K, Kitoh H, Iwata K, Matsushita M, Nishida Y, Hattori T, Ishiguro N

Medicine (Baltimore)   Vol. 95 ( 21 ) page： e3787   2016.5

Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters Invited Reviewed

Hasegawa S, Kitoh H, Ohkawara B, Mishima K, Matsushita M, Masuda A, Ishiguro N, Ohno K

Biochem Biophys Res Commun   Vol. 470 ( 2 ) page： 356 - 361   2016.2

Characterisation of novel RUNX2 mutation with alanine tract expansion from Japanese cleidocranial dysplasia patient Invited Reviewed

Shibata A, Machida J, Yamaguchi S, Kimura M, Tatematsu T, Miyachi H, Matsushita M, Kitoh H, Ishiguro N, Nakayama A, Higashi Y, Shimozato K, Tokita Y

Mutagenesis   Vol. 31 ( 1 ) page： 61 - 67   2016.1

Low bone mineral density in achondroplasia and hypochondroplasia Reviewed

Matsushita M, Kitoh H, Mishima K, Kadono I, Sugiura H, Hasegawa S, Nishida Y, Ishiguro N

Pediatr Int     page： 10.1111/ped.12890   2016

Prediction of Clinically Significant Leg-Length Discrepancy in Congenital Disorders Invited Reviewed

Mishima K, Kitoh H, Kadono I, Matsushita M, Sugiura H, Hasegawa S, Kitamura A, Nishida Y, Ishiguro N

Orthopedics   Vol. 38 ( 10 ) page： e919 - e924   2015.10

Meclozine promotes lomgitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene Reviewed

Matsushita M, Hasegawa S, Kitoh H, Mori K, Ohkawara B, Yasoda A, Masuda A, Ishiguro N, Ohno K

Endocrinology   Vol. 156   page： 548-554   2015

A glutamine repeat variant of the RUNX2 gene causes cleidocranial dysplasia Reviewed

Matsushita M, Kitoh H, Subasioglu A, Colak FK, Dundar M, Mishima K, Nishida Y, Ishiguro N

Mol Syndromol     page： in press   2015

Factors associated with an unfavourable outcome after Salter innominate osteotomy in patients with unilateral developmental dysplasia of the hip: Does occult dysplasia of the contralateral hip affect the outcome? Invited Reviewed

Kaneko H, Kitoh H, Mishima K, Matsushita M, Kadono I, Ishiguro N, Hattori T

Bone Joint J   Vol. 96-B ( 10 ) page： 1419 - 1423   2014.10

Early and late fracture following extensive limb lengthening in achondroplasia and hypochondroplasia Invited Reviewed

Kitoh H, Kaneko H, Mishima K, Matsushita M, Kadono I, Nishida Y, Ishiguro N

Bone Joint J   Vol. 96-B ( 9 ) page： 1269 - 1273   2014.9

Radiographic characteristics of the hand and cervical spine in fibrodysplasia ossificans progressiva Invited Reviewed

Mishima K, Kitoh H, Haga N, Nakashima Y, Kamizono J, Katagiri T, Susami T, Matsushita M, Ishiguro N

Intractable Rare Dis Res   Vol. 3 ( 2 ) page： 46 - 51   2014.5

A case of severe proximal focal femoral deficiency with overlapping phenotypes of Al-Awadi-Raas-Rothschild syndrome and Fuhrmann syndrome Reviewed

Matsushita M, Kitoh H, Mishima K, Nishida Y, Ishiguro N

Ped Radiol   Vol. 44   page： 1617-1619   2014

Benign prenatal hypophosphatasia: a treatable disease not to be missed Reviewed

Matsushita M, Kitoh H, Michigami T, Tachikawa K, Kaneko H, Mishima K, Ishiguro N

Ped Radiol   Vol. 44   page： 340-343   2014

A novel in-flame deletion of the RUNX2 gene causes a classic form of cleidocranial dysplasia Reviewed

Matsushita M, Kitoh H, Kaneko H, Mishima K, Itoh Y, Tokita Y, Ishiguro N

J Bone Miner Metab   Vol. 32   page： 96-99   2014

A comparative study of blade plate fixation and external fixation in osteotomies for slipped capital femoral epiphysis Invited Reviewed

Kitoh H, Kitakoji T, Hattori T, Kaneko H, Mishima K, Matsushita M, Ishiguro N

J Pediatr Orthop B   Vol. 22 ( 6 ) page： 542 - 547   2013.11

Perhexiline maleate in the treatment of fibrodysplasia ossificans progressiva: an open-labeled clinical trial Invited Reviewed

Kitoh H, Achiwa M, Kaneko H, Mishima K, Matsushita M, Kadono I, Horowitz JD, Sallustio BC, Ohno K, Ishiguro N

Orphanet J Rare Dis   Vol. 8   page： 163   2013.10

Long-term outcome of gradual reduction using overhead traction for developmental dysplasia of the hip over 6 months of age Invited Reviewed

Kaneko H, Kitoh H, Mishima K, Matsushita M, Ishiguro N

J Pediatr Orthop   Vol. 33 ( 6 ) page： 628 - 634   2013.9

Prognostic factors for trochanteric overgrowth after containment treatment in Legg-Calvé-Perthes disease Invited Reviewed

Kitoh H, Kaneko H, Mishima K, Matsushita M, Ishiguro N

J Pediatr Orthop B   Vol. 22 ( 5 ) page： 432 - 436   2013.9

Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice Invited Reviewed

Yamamoto R, Matsushita M, Kitoh H, Masuda A, Ito M, Katagiri T, Kawai T, Ishiguro N, Ohno K

J Bone Miner Metab   Vol. 31 ( 1 ) page： 26 - 33   2013.1

Orthopaedic manifestations and diagnostic clues in children with Guillain-Barré syndrome Reviewed

Matsushita M, Kitoh H, Itomi K, Kitakoji T, Iwata K, Mishima K, Ishiguro N, Hattori T

J Child Orthop   Vol. 7   page： 177-182   2013

Meclozine facilitates chondrocyte proliferation and differentiation by attenuating abnormally activated fibroblast growth factor receptor 3 (FGFR3) signaling in achondroplasia Reviewed

Matsushita M, Kitoh H, Ohkawara B, Mishima K, Kaneko H, Ito M, Masuda A, Ishiguro N, Ohno K

PLoS One   Vol. 8   page： e81569   2013

A novel SOX9 H169Q mutation in a family with overlapping phenotype of mild campomelic dysplasia and small patella syndrome Reviewed

Matsushita M, Kitoh H, Kaneko H, Mishima K, Kadono I, Ishiguro N, Nishmura G

Am J Med Genet A   Vol. 161   page： 2528-2534   2013

Isolated bifid rib: clinical and radiological findings in children Invited Reviewed

Kaneko H, Kitoh H, Mabuchi A, Mishima K, Matsushita M, Ishiguro N

Pediatr Int   Vol. 54 ( 6 ) page： 820 - 823   2012.12

Novel compound heterozygous mutations in the cathepsin K gene in Japanese female siblings with pyknodysostosis Reviewed

Matsushita M, Kitoh H, Kaneko H, Mishima K, Itoh Y, Hattori T, Ishiguro N

Mol Syndromol   Vol. 2   page： 254-258   2012

雑誌「小児内科」増刊号：小児疾患の診断治療基準　改訂5版（第2部：疾患　XIX.運動器疾患）

松下雅樹（ Role： Contributor ,  393.軟骨無形成症）

株式会社東京医学社  2018 

Prediction of Clinically Significant Leg-Length Discrepancy in Congenital Disorders. Reviewed

Mishima K, Kitoh H, Kadono I, Matsushita M, Sugiura H, Hasegawa S, Kitamura A, Nishida Y, Ishiguro N

Orthopedics   Vol. 38 ( 10 ) page： e919-24   2015.10

Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene. Reviewed

Matsushita M, Hasegawa S, Kitoh H, Mori K, Ohkawara B, Yasoda A, Masuda A, Ishiguro N, Ohno K

Endocrinology   Vol. 156 ( 2 ) page： 548-54   2015.2

A case of severe proximal focal femoral deficiency with overlapping phenotypes of Al-Awadi-Raas-Rothschild syndrome and Fuhrmann syndrome. Reviewed

Matsushita M, Kitoh H, Mishima K, Nishida Y, Ishiguro N

Pediatric radiology   Vol. 44 ( 12 ) page： 1617-9   2014.12

Radiographic characteristics of the hand and cervical spine in fibrodysplasia ossificans progressiva. Reviewed

Mishima K, Kitoh H, Haga N, Nakashima Y, Kamizono J, Katagiri T, Susami T, Matsushita M, Ishiguro N

Intractable & rare diseases research   Vol. 3 ( 2 ) page： 46-51   2014.5

Benign prenatal hypophosphatasia: a treatable disease not to be missed. Reviewed

Matsushita M, Kitoh H, Michigami T, Tachikawa K, Ishiguro N

Pediatric radiology   Vol. 44 ( 3 ) page： 340-3   2014.3

A novel in-frame deletion of the RUNX2 gene causes a classic form of cleidocranial dysplasia. Reviewed

Matsushita M, Kitoh H, Kaneko H, Mishima K, Itoh Y, Tokita Y, Ishiguro N

Journal of bone and mineral metabolism   Vol. 32 ( 1 ) page： 96-9   2014.1

A comparative study of blade plate fixation and external fixation in osteotomies for slipped capital femoral epiphysis. Reviewed

Kitoh H, Kitakoji T, Hattori T, Kaneko H, Mishima K, Matsushita M, Ishiguro N

Journal of pediatric orthopedics. Part B   Vol. 22 ( 6 ) page： 542-7   2013.11

Perhexiline maleate in the treatment of fibrodysplasia ossificans progressiva: an open-labeled clinical trial. Reviewed

Kitoh H, Achiwa M, Kaneko H, Mishima K, Matsushita M, Kadono I, Horowitz JD, Sallustio BC, Ohno K, Ishiguro N

Orphanet journal of rare diseases   Vol. 8   page： 163   2013.10

A novel SOX9 H169Q mutation in a family with overlapping phenotype of mild campomelic dysplasia and small patella syndrome. Reviewed

Matsushita M, Kitoh H, Kaneko H, Mishima K, Kadono I, Ishiguro N, Nishimura G

American journal of medical genetics. Part A   Vol. 161A ( 10 ) page： 2528-34   2013.10

Long-term outcome of gradual reduction using overhead traction for developmental dysplasia of the hip over 6 months of age. Reviewed

Kaneko H, Kitoh H, Mishima K, Matsushita M, Ishiguro N

Journal of pediatric orthopedics   Vol. 33 ( 6 ) page： 628-34   2013.9

Prognostic factors for trochanteric overgrowth after containment treatment in Legg-Calvé-Perthes disease. Reviewed

  Vol. 22 ( 5 ) page： 432-6   2013.9

Orthopaedic manifestations and diagnostic clues in children with Guillain-Barré syndrome. Reviewed

  Vol. 7 ( 3 ) page： 177-82   2013.6

Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice. Reviewed

Yamamoto R, Matsushita M, Kitoh H, Masuda A, Ito M, Katagiri T, Kawai T, Ishiguro N, Ohno K

Journal of bone and mineral metabolism   Vol. 31 ( 1 ) page： 26-33   2013.1

Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia. Reviewed

Matsushita M, Kitoh H, Ohkawara B, Mishima K, Kaneko H, Ito M, Masuda A, Ishiguro N, Ohno K

PloS one   Vol. 8 ( 12 ) page： e81569   2013

Isolated bifid rib: clinical and radiological findings in children. Reviewed

Kaneko H, Kitoh H, Mabuchi A, Mishima K, Matsushita M, Ishiguro N

Pediatrics international : official journal of the Japan Pediatric Society   Vol. 54 ( 6 ) page： 820-3   2012.12

軟骨無形成症マウスモデルを用いた成長ホルモンとメクロジンの併用投与による効果の検討

澤村健太、松下雅樹、三島健一、神谷庸成、鬼頭浩史、大野欽司、今釡史郎

第39回日本整形外科基礎学術集会 

変形性膝関節症マウスモデルにおけるFGFR3シグナルの効果

藤井整、松下雅樹、石塚真哉、三島健一、神谷庸成、澤村健太、鬼頭浩史、今釜史郎

第39回日本整形外科基礎学術集会 

Oral Administration of Meclozine Rescues Spinal Canal Stenosis in a Mouse Model of Achondroplasia International conference

Masaki Matsushita, Hiroto Funahashi, Kenichi Mishima, Kenta Sawamura, Shiro Imagama

ASBMR 2024 Annual Meeting 

多発性軟骨性外骨腫症に対するエイトプレートを用いた脚長差の補正と下肢アライメント矯正の治療成績

松下雅樹、三島健一、神谷庸成、澤村健太、今釜史郎

第97回日本整形外科学会学術総会 

閉経後マウスモデルにおける変形性膝関節症に対するFGFR3シグナルの効果の検討

藤井整、松下雅樹、石塚真哉、三島健一、神谷庸成、澤村健太、鬼頭浩史、今釜史郎

第36回日本軟骨代謝学会 

Meclozine ameliorates osteogenic mineralization of bone marrow-derived mesenchymal stem cells using a mouse model of achondroplasia International conference

Masaki Matsushita, Itaru Kawashima, Kenichi Mishima, Yasunari Kamiya, Kinji Ohno, Hiroshi Kitoh, Shiro Imagama

Orthopaedic Research Society 2024 Annual Meeting 

軟骨無形成症マウスモデルを用いたFGFR3インヒビターの大後頭孔と脊柱管に対する効果の検討

松下雅樹、船橋洋人、三島健一、神谷庸成、澤村健太、鬼頭浩史、大野 欽司、今釜史郎

第35回骨系統疾患研究会 

多発性軟骨性外骨腫症に対するエイトプレートを用いた脚長補正と下肢アライメント矯正の検討

松下雅樹、三島健一、神谷庸成、澤村健太、今釜史郎

第34回日本小児整形外科学会学術集会 

メクロジンの経口投与は軟骨無形成症マウスモデルの脊柱管を拡大し麻痺の発生率を低減する

船橋洋人、松下雅樹、三島健一、神谷庸成、澤村健太、鬼頭浩史、大野 欽司、今釜史郎

第38回日本整形外科基礎学術集会 

A 14-day repeated oral administration of meclizine in child patients with achondroplasia to evaluate safety and pharmacokinetics International conference

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Yasunari Kamiya, Kenta Sawamura, Kazuki Nishida, Yasuhiro Nakai, Shiro Imagama

ASBMR 2023 Annual Meeting 

Gradual reduction using overhead traction for developmental dysplasia of the hip (DDH): protocol, results, and MRI findings Invited International conference

Masaki Matsushita

2023 Shengjing Pediatric Orthopedics Summit Forum---Developmental Dysplasia of the Hip 

Treatment strategy of DDH in Nagoya, Japan Invited International conference

Masaki Matsushita

2023 Shengjing Pediatric Orthopedics Summit Forum---Developmental Dysplasia of the Hip 

脊柱管狭窄症とFGFR3異常症

松下雅樹、鬼頭浩史、三島健一、神谷庸成、澤村健太、今釜史郎

第96回日本整形外科学会学術総会 

軟骨無形成症患児を対象としたFGFR3シグナル抑制薬の14日間連続経口投与第1b相治験

松下雅樹、鬼頭浩史、三島健一、神谷庸成、加藤大策、竹本元太、澤村健太、今釜史郎

第96回日本整形外科学会学術総会 

FGFR3シグナルは、若年マウスの阻血性骨壊死の骨修復を加速する

加藤大策、松下雅樹、竹上靖彦、三島健一、神谷宣広、大澤侑介、今釜史郎、鬼頭浩史

第35回日本軟骨代謝学会 

Long-term oral administration of meclozine for the treatment of achondroplasia using a mouse model International conference

Funahashi H, Matsushita M, Mishima K, Okawara B, Kamiya Y, Ohno K, Kitoh H, Imagama S

Orthopaedic Research Society 2023 Annual Meeting 

軟骨無形成症治療の現在と未来

松下雅樹

第19回東海小児整形外科研修会 

骨系統疾患の成人期における健康関連QOLの検討

松下雅樹、鬼頭浩史、三島健一、神谷庸成、芳賀信彦、藤原清香、大薗恵一、安心院朗子、今釜史郎

第59回日本リハビリテーション医学会学術集会 

軟骨無形成症患児を対象としたFGFR3シグナル抑制薬投与第1相治験

松下雅樹、三島健一、神谷庸成、加藤大策、竹本元太、今釜史郎、鬼頭浩史

第95回日本整形外科学会学術総会 

7. Abnormal growth plate structure in mouse model of hypophosphatemic rickets is ameliorated by meclozine treatment International conference

Yasunari Kamiya, Masaki Matsushita, Kenichi Mishima, Bisei Ohkawara, Shiro Imagma, Kinji Ohno, Hiroshi Kitoh

Orthopaedic Research Society 2022 Annual Meeting 

Health-related quality of life in patients with multiple epiphyseal dysplasia and spondyloepiphyseal dysplasia International conference

Masaki Matsushita, Kenichi Mishima, Yasunari Kamiya, Nobuhiko Haga, Sayaka Fujiwara, Keiichi Ozono, Takuo Kubota, Taichi Kitaoka, Shiro Imagama, Hiroshi Kitoh

13th Combined Meeting of Asia Pacific Spine Society & Asia Pacific Paediatric Orthopaedic Society (APSS-APPOS 2021) 

Efficacy and tolerability of meclozine for the treatment of short stature in a mouse model of achondroplasia International conference

Masaki Matsushita, Kenichi Mishima, Tadashi Nagata, Yasunari Kamiya, Shiro Imagama, Kinji Ohno, Hiroshi Kitoh

2021 Annual Meeting - Orthopaedic Research Society (ORS) 

Periosteal resection promotes longitudinal bone growth via activating endochondral ossification in growing mouse model International conference

Shinya Kaneko, Masaki Matsushita, Kenichi Mishima, Hiroshi Kitoh, Naoki Ishiguro

2020 Annual Meeting - Orthopaedic Research Society (ORS) 

Efficacy of soluble lansoprazole-impregnated artificial bones for repairing cortical bone defects in rabbits International conference

Kenichi Mishima, Ryusaku Esaki, Masaki Matsushita, Naoki Ishiguro

2020 Annual Meeting - Orthopaedic Research Society (ORS) 

Local administration of meclozine promotes the longitudinal growth of selected bone in mouse model International conference

Tadashi Nagata, Masaki Matsushita, Kenichi Mishima, Yasunari Kamiya, Bisei Ohkawara, Kinji Ohno, Naoki Ishiguro, Hiroshi Kitoh

2020 Annual Meeting - Orthopaedic Research Society (ORS) 

Meclozine promotes bone growth and bone mineralization in mouse model of hypophosphatemic rickets International conference

Yasunari Kamiya, Masaki Matsushita, Kenichi Mishima, Tadashi Nagata, Naoki Ishiguro, Kinji Ono, Hiroshi Kitoh

2020 Annual Meeting - Orthopaedic Research Society (ORS) 

Drug repositioning for FGF23-mediated hypophosphatemia: Disulfiram lowers FGF23 production International conference

Kenichi Mishima, Hiroshi Sugiura, Ryusaku Esaki, Masaki Matsushita, Hiroshi Kitoh, Naoki Ishiguro, Kinji Ohno

2019 Annual Meeting - Orthopaedic Research Society (ORS) 

Long term health-related quality of life in patients with achondroplasia and hypochondroplasia International conference

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Naoki Ishiguro, Sayaka Fujiwara, Nobuhiko Haga, Taichi Kitaoka, Takuo Kubota, Keiichi Ozono

American Society for Bone and Mineral Research (ASBMR) 2018 Annual Meeting 

小児先天性疾患に合併した下腿変形に対するMAC創外固定器による矯正

松下雅樹、鬼頭浩史、三島健一、長田侃、金子浩史、岩田浩志、服部義、石黒直樹

第31回日本創外固定・骨延長学会  2018.8.4 

Bone formation was promoted in mouse model of distraction osteogenesis with gain-of-function mutation in FGFR3 International conference

Masaki Matsushita, Yusuke Ohsawa, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno, Hiroshi Kitoh

Fibroblast Growth Factors in Development & Disease - Gordon Research Conference 2018 

Treatment of the lower limb deformities by a multi-axial external fixation system Invited International conference

Masaki Matsushita, Hiroshi Kitoh, Tadashi Hattori, Hiroshi Kaneko, Kenichi Mishima, Naoki Ishiguro

The 61st Korean Orthopaedic Association Annual Meeting 

Clinically Feasible Dose of Meclozine Improves Bone Growth, Bone Volume, and Bone Quality in Mouse Model with Achondroplasia International conference

Masaki Matsushita, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno, Hiroshi Kitoh

The 27th Korean-Japanese Combined Orthopaedic Symposium (KJCOS) 2017 

Clinically feasible dose of meclozine promotes bone growth in mouse model with achondroplasia International conference

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Hiroshi Sugiura, Sachi Hasegawa, Akiko Kitamura, Naoki Ishiguro, Kinji Ohno

2017 Annual Meeting - Orthopaedic Research Society (ORS) 

Long term health-related quality of life in achondroplasia International conference

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Satoshi Yamashita, Hiroshi Sugiura, Akiko Kitamura, Naoki Ishiguro

Combined European Paediatric Orthopaedic Society and Pediatric Orthopaedic Society of North America (EPOSNA) 2017 Annual meeting 

Clinical feasibility of meclozine for improvement of short stature in achondroplasia International conference

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Hiroshi Sugiura, Akiko Kitamura, Naoki Ishiguro

Combined European Paediatric Orthopaedic Society and Pediatric Orthopaedic Society of North America (EPOSNA) 2017 Annual meeting 

軟骨無形成症に対する根本的治療の開発

松下雅樹、鬼頭浩史、 三島健一、杉浦洋、長谷川幸、北村暁子、石黒直樹、大野欽司

第27回日本小児整形外科学会  2016.12.1 

Clinical feasibility of oral administration of meclozine for the treatment of short stature in achondroplasia International conference

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno

American Society for Bone and Mineral Research (ASBMR) 2016 Annual Meeting 

Clinically attainable concentration of meclozine has a potent effect on promoting bone growth in achondroplasia International conference

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno

Annual Meetings of the Endocrine Society of Australia and Society for Reproductive Biology and Australia and New Zealand Bone and Mineral Society 2016 

Clinically attainable concentration of meclozine promotes bone growth in transgenic mice with achondroplasia International conference

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno

Fibroblast Growth Factors in Development & Disease - Gordon Research Conference 2016 

Radical therapeutic strategy for foramen magnum stenosis and spinal canal stenosis in achondroplasia International conference

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Hiroshi Sugiura, Sachi Hasegawa, Akiko Kitamura, Naoki Ishiguro, Kinji Ohno

2016 Annual Meeting - Orthopaedic Research Society (ORS) 

軟骨無形成症治療の現在と未来 Invited

松下雅樹

Nordiscience Ach workshop  2015.11.21 

Meclozine has a potential effects on short stature and foramen magnum stenosis in transgenic mice with achondroplasia International conference

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Hiroshi Sugiura, Sachi Hasegawa, Akiko Kitamura, Ishiguro Naoki, Ohno Kinji

7th International Conference on Children’s Bone Health (ICCBH) 2015 

Meclozine promotes longitudinal bone growth in transgenic achondroplasia mice with gain-of-function mutation in FGFR3 gene International conference

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Naoki Ishiguro

2015 Pediatric Orthopaedic Society of North America (POSNA) Annual Meeting 

Meclozine enhances skeletal growth in transgenic achondroplasia mice with a constitutive active FGFR3 mutation International conference

Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno

2015 Annual Meeting - Orthopaedic Research Society (ORS) 

Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia International conference

Masaki Matsushita, Hiroshi Kitoh, Hiroshi Kaneko, Kenichi Mishima, Naoki Ishiguro

2014 Pediatric Orthopaedic Society of North America (POSNA) Annual Meeting 

Meclozine facilitates chondrocyte proliferation and differentiation by attenuating abnormally activated FGFR3 signaling in achondroplasia International conference

Masaki Matsushita, Hiroshi Kitoh, Hiroshi Kaneko, Kenichi Mishima, Naoki Ishiguro, Kinji Ohno

International Skeletal Dysplasia Society (ISDS) Meeting 2013 

Drug repositioning for inhibiting the FGFR3 signaling in the treatment of short stature in achondroplasia International conference

Masaki Matsushita, Hiroshi Kitoh, Naoki Ishiguro, Kinji Ohno

2013 Annual Meeting - Orthopaedic Research Society (ORS) 

Guillain-Barré syndrome of children -diffficulty to diagnosis in the orthopedic field- International conference

Masaki Matsushita, Tadashi Hattori, Takahiko Kitakoji, Hiroshi Iwata

Asia Pacific Orthopaedic Association (APOA), Spine and Pediatric Sections 2011 

ドラッグ・リポジショニングによる軟骨無形成症治療薬の開発研究

Grant number：15652612  2015 - 2017.3

国立研究開発法人日本医療研究開発機構  早期探索的・国際水準臨床研究事業 

ドラッグ・リポジショニングによる軟骨無形成症治療薬の開発研究

Grant number：14539654  2014 - 2015.3

厚生労働科学研究費補助金 

多階層シングルセル解析を応用した骨再生機構の解明と新規再生療法の基盤構築

Grant number：23K21487  2022.2 - 2025.3

科学研究費助成事業  基盤研究(B)

松下 祐樹, 尾崎 遼, 住田 吉慶, 松下 雅樹

Development of therapeutic drugs fro achondroplasia-Examination of FGFR3 inhibitory effects of meclizine hydrochloride

Grant number：21H03063  2021.4 - 2024.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

骨延長マウスモデルにおけるメクロジンのFGFR3抑制効果の検討

Grant number：20K09477  2020.4 - 2024.3

科学研究費助成事業  基盤研究(C)

神谷 庸成, 鬼頭 浩史, 三島 健一, 松下 雅樹, 長田 侃

ドラッグリポジショニングによるペルテス病の新規治療法の開発

Grant number：19K09573  2019.4 - 2024.3

科学研究費助成事業  基盤研究(C)

三島 健一, 鬼頭 浩史, 松下 雅樹, 長田 侃, 神谷 庸成

新規軟骨無形成症治療薬開発研究

Grant number：19K09646  2019.4 - 2024.3

科学研究費助成事業  基盤研究(C)

松下 雅樹, 鬼頭 浩史, 三島 健一, 長田 侃, 神谷 庸成

FGFR3インヒビターの局所投与による骨伸長促進効果の検討

Grant number：19K09596  2019.4 - 2021.3

科学研究費助成事業  基盤研究(C)

長田 侃, 鬼頭 浩史, 三島 健一, 松下 雅樹, 神谷 庸成

Investigation of osteochondral function via activation of FGFR3 signaling

Grant number：17H04312  2017.4 - 2020.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

Kitoh Hiroshi

Drug repositioning for successful healing of bone fractures or defects

Grant number：16K10854  2016.4 - 2020.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

MISHIMA KENICHI

Development of therapeutic drugs for fibrodysplasia ossificans progressiva by drug repositioning strategies

Grant number：15K15548  2015.4 - 2018.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

Kitoh Hiroshi

Animal study for evaluating the effect of meclozine on FGFR3 signaling

Grant number：15K10439  2015.4 - 2018.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Matsushita Masaki

軟骨無（低）形成症患者さんの生活　～アンケート調査より～

Role(s)：Informant

つくしんぼ総会  2018.4

低身長症患者さんの生活（アンケート調査より）

Role(s)：Lecturer,　Informant

名古屋小児整形外科医会　市民公開講座 「低身長について」  2018.2

軟骨無形成症治療の現在と未来

Role(s)：Lecturer,　Informant

つくしんぼ総会  2016.4