Organization
Graduate School of Medicine Lecturer
Graduate School
Graduate School of Medicine
Undergraduate School
School of Health Sciences
Title
Lecturer
TAKENO Yukari
Degree 1
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PhD(Nursing) （ 2013.6 Nagoya University ）
Education 2
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Nagoya University Graduate School, Division of Medical Sciences
- 2013.3
Country： Japan
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Flinders University Graduate School, Division of Nursing
- 2006.11
Country： Japan
Awards 1
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Postgraduate Research Award
2007.5 Flinders University
Papers 14
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Key challenges in nurse-led foot care education for persons with diabetes: an international survey across six countries. Reviewed International coauthorship Open Access
Liu Y, Riklikiene O, Ezenwaka C, Nwankwo CU, Zhu S, Makhanbetkulova D, Analike RA, Bulikaite V, Dabyl A, Fan X, Victor V, Zhang Q, Takeno Y
BMC nursing Vol. 25 ( 1 ) 2026.3
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Coefficient of Variation of R-R Intervals During Deep Breathing as a Risk Marker of Orthostatic Blood Pressure Decline in Patients with Type 2 Diabetes Mellitus Reviewed
Nagoya Journal of Medical Science 2026
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Foot Care Education and Self-Efficacy Practices Among Diabetic Patients in Developing Countries: A Cross-Country Survey Reviewed International coauthorship Open Access
Ezenwaka C1, Nwankwo C, Analike R, Liu Y, Okoh O, Victor V, Takeno Y, Daniel E, Onyeje B , Afonne A and Okoli J
Diabetes Complications Vol. 10 ( 1 ) 2026
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Hisano, F; Watanabe, S; Niwa, S; Nakanishi, K; Mawaki, A; Takeno, Y; Murota, K; Honda, I; Fujimoto, E; Oshima, C
LYMPHATIC RESEARCH AND BIOLOGY Vol. 21 ( 2 ) page： 179 - 186 2023.4
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Hisano, F; Niwa, S; Nakanishi, K; Mawaki, A; Murota, K; Fukuyama, A; Takeno, Y; Watanabe, S; Fujimoto, E; Oshima, C
LYMPHATIC RESEARCH AND BIOLOGY Vol. 19 ( 3 ) page： 269 - 273 2021.6
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LONG-TERM FOLLOW-UP OF COLLATERAL PATHWAYS ESTABLISHED AFTER LYMPHADENECTOMY IN RATS
Takeno Y., Arita H., Oshima C., Mawaki A., Nakanishi K., Kurono F., Fujimoto E.
LYMPHOLOGY Vol. 50 ( 3 ) page： 131-135 2017.9
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Nighttime bandaging to reduce lymphedema swelling: a clinical pre-post study Reviewed
Nakanishi Keisuke, Mawaki Ayana, Oshima Chika, Takeno Yukari, Kurono Fumiya, Murotani Kenta, Kikumori Toyone and Fujimoto Etsuko
SAGE Open Nursing Vol. 3 page： 1-8 2017
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Long-term follow-up of collateral pathways established after lymphadenectomy in rats.
Takeno Y, Arita H, Oshima C, Mawaki A, Nakanishi K, Kurono F, Fujimoto E
Lymphology Vol. 50 ( 3 ) page： 131 - 135 2017
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安全な吸引のために ―解剖生理学的知識と手技―
藤本悦子、竹野ゆかり
理学療法学 Vol. 40 ( 4 ) page： 335-334 2013
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Sleep disturbance in elderly patients after cardiac surgery during their stay in intensive care unit and surgical ward
Arita, H., Takeno, Y., Fujimoto, E.
Journal of Nursing & Care 2013
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Alternations of lymph flow after lymphadenectomy in rats revealed by real time fluorescence imaging system
Takeno, Y., Fujimoto, E.
Lymphology Vol. 46 ( 1 ) page： 12-19 2013
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Efficacy of complete decongestive therapy (CDT) on edematous rat limb after lymphadenectomy demonstrated by real time lymphatic fluid tracing Open Access
Takeno, Y., Arita, H., Fujimoto, E.
SpringerPlus Vol. 2 ( 225 ) 2013
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外国人看護師とともに働くための一歩--インドネシア人看護師の看護技術に着目して
竹野ゆかり、Dewi Wan Nishfa、Agustina Hana Rizmadewi
日本看護技術学会誌 Vol. 10 ( 1 ) page： 66-68 2011
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Facilitating the transition of Asian nurses to work in Australia
Takeno, Y.
Journal of Nursing Management Vol. 18 ( 2 ) page： 215-224 2010
Books 5
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人体の構造と機能 第５班
（ Role： Joint translator）
医学書院 2025.2
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人体の構造と機能 第4版
Elaine N. Marieb、林正健二、今本喜久子、遠藤健司、大島千佳、小田切陽一、武田多一、武田裕子、竹野ゆかり、藤本悦子（ Role： Joint author）
医学書院 2015.3
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看護師国試状況設定完全予想問題集
大津廣子、小松万喜子他（ Role： Joint author）
成美堂 2014.11
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解剖生理学から見直す看護技術
藤本悦子、有田広美、荒井孝子、大島千佳、木室ゆかり、石田陽子、三浦奈都子、武田利明、竹野ゆかり、深井喜代子、菱沼典子、大久保暢子、澤本美千代（ Role： Joint author）
学研メディカル 2012
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手術室看護手順 第2版
舩橋朋子、池田好美、伊藤綾乃、岡本彩、金子弘美、黒田暢子、佐藤晃子、筋田真弓、竹野ゆかり、大黒谷好恵、錦織純子、花柗有美、吉田京子（ Role： Joint author）
医学書院 1998
Presentations 29
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看護系大学学部学生に対するリンパ浮腫ケア教育-セラピストの増大をめざして-
藤本悦子、安藤詳子、中西啓介、竹野ゆかり、間脇彩奈、大島千佳
看護科学学会第37回学術集会
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糖尿病は間質液の尿への移行を遅延させるかーイヌリンを指標としてー
竹野ゆかり、堀夏美、田村舞帆、藤本悦子
コ・メディカル形態機能学会第15回学術集会
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リンパ浮腫ケアの新たなステージ
藤本悦子、大島千佳、竹野ゆかり、中西啓介、永谷幸子、谷保由依子、黒野史椰
日本看護技術学会第14回学術集会
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イヌリンを指標とした間質液の動態と肥満との関係
田村 舞帆、堀 夏美、竹野 ゆかり、大島 千佳）、藤本 悦子
コ・メディカル形態機能学会第14回学術集会
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多層包帯法が睡眠に与える影響
児玉侑紀、高羽杏奈、大島千佳、間脇彩奈、竹野ゆかり、藤本悦子
コ・メディカル形態機能学会第14回学術集会
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A follow-up study of collateral pathways established after lymphadenectomy in rats International conference
Takeno, Y, Nakanishi, K, Mawaki, A, Oshima, C, Arita, H, Fujimoto, E.
25th World Congress of Lymphology
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PATTTERN OF FLUID ACCUMULATION IN THE LYMPHEDEMATOUS ARM REVEALED BY MAGNETIC RESONANCE International conference
FUJIMOTO,E, TANIHO, Y, MAWAKI, A, OSHIMA, C, NAKANISHI, K, TAKENO, Y.
25th World Congress of Lymphology
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Exretion patterns of urinary melatonin after cardiac surgery in elderly patients International conference
Arita, H, Takeno, Y, Fujimoto, E.
18th EAFONS
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巻尺で測定した周囲径と自覚症状はリンパ浮腫の指標として使えるか
谷保由依子,間脇彩奈,大島千佳,竹野ゆかり,藤本悦子
日本看護技術学会第13回学術集会
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リンパ浮腫患者の皮膚粘弾性-スキンケアのpreliminary study として-
間脇彩奈, 谷保由依子, 大島千佳, 竹野ゆかり, 藤本悦子
日本看護技術学会第13回学術集会
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リンパ節切除後のリンパ動態の変化―リアルタイムイメージング法を用いた解析-
竹野ゆかり、藤本悦子
日本解剖学会第７４会中部支部学術集会
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腋窩リンパ節切除後のリンパ動態の変化
竹野ゆかり、中西啓介、間脇彩奈、有田広美、大島千佳、藤本悦子
コ・メディカル形態機能学会第13回学術集会
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リンパ流速の測定方法の開発-疾患との関連において-
野田さつき、水野花奈美、渡邉真季、八木街子、中西啓介、竹野ゆかり、藤本悦子
コ・メディカル形態機能学会第13回学術集会
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上肢リンパ浮腫における水分の分布-MR画像を用いて-
谷保由依子,間脇彩奈,竹野ゆかり,大島千佳,安藤詳子,藤本悦子
日本看護研究学会大40回学術集会
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Efficacy of complete decongestive therapy (CDT) on edematous rat limb after lymphadenectomy demonstrated by real time lymphatic fluid tracing International conference
Takeno, Y., Arita, H., Fujimoto, E.
24th. World Congress of International Society of Lymphology
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ラットのリンパ動態に関する研究 分水嶺の探索
黒野史椰、竹野ゆかり、大島千佳、 藤本悦子
第12回コメディカル形態機能学会学術集会
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効果的なドライシャンプーの検討 洗髪前の蒸しタオルの使用について
間脇彩奈、竹野ゆかり、藤本悦子
第39回日本看護研究学会
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Facilitation in a work setting for the transition of Indonesian nurses in Japan: Contrast with Kuwaiti health care system International conference
Takeno, Y., Arita, H., Fujimoto, E.
ICN 25th Quadrennial Congress
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Establishment of new lymphatic routes from edematous limb after lymphadenectomy in rats International conference
Takeno, Y. Arita, H. Fujimoto, E.
3rd. Nagoya-Yonsei university research exchange meeting on Health Sciences
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リンパ経路遮断後のリンパ動態の変化 リンパドレナージの検討を示唆する基礎研究
竹野ゆかり 林美希 藤本悦子
第11回日本看護技術学会学術集会
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肥満ラットにおけるリンパの流れについての検討
佐伯街子、大島千佳、永谷幸子、間脇彩奈、竹野ゆかり、林美希、藤本悦子
第11回コメディカル形態機能学会学術集会
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複合的治療による上肢リンパ浮腫の変化 MRIを用いた検討
林美希、竹野ゆかり、 藤本悦子
第11回日本看護技術学会学術集会
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続発性リンパ浮腫を来した患肢の内部構造と液体貯留部位 MRIを用いたpreliminary study
藤本悦子 竹野ゆかり 大島千佳、永谷幸子、 佐伯街子、間脇彩奈、 安藤祥子、林美希
第38回日本看護研究学会
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リンパ節切除後のリンパ動態の変化 リンパ浮腫ケアの基礎研究として
竹野ゆかり、 永谷幸子、大島千佳、藤本悦子
第31回日本看護科学学会学術集会
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インドネシア人看護師の日本就労目的とそれに対する日本の課題
竹野ゆかり
第30回日本看護科学学会学術集会
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インドネシア人看護師とともに働いていくために：インドネシアの看護教育からの検討
竹野ゆかり, Dewi Wan Nishfa
第13回国際看護研究学会学術集会
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Decision-making process to migrate to Australia: Case studiesof Korean and Japanese nurses International conference
Takeno, Y., Fujimoto, E.
12th. East Asian Forum of Nursing Scholars (EAFONS)
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Education for the transition of Asian Nurses to work in Australia International conference
Takeno, Y.
ICN Conference 2007
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Facilitating the transition of Asian nurses of work in Australia International conference
Takeno, Y.
Royal College of Nursing Australia
KAKENHI (Grants-in-Aid for Scientific Research) 12
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筋損傷に対する筋内リンパ管の役割とその役割に着目した治療戦略
Grant number：23K24698 2024.4 - 2026.3
科学研究費助成事業 基盤研究(B)
河上 敬介, 縣 信秀, 紀 瑞成, 竹野 ゆかり
Authorship：Coinvestigator(s)
力学刺激が筋損傷からの回復を促進させることが分かっている。一方、筋損傷からの回復におけるリンパ管の役割は不明であり、その分布すら分かっていない。我々は、筋内のリンパ管が他の組織と異なる大きさや分布を呈すること、そのリンパ管の数や大きさが筋損傷後の回復早期に通常の約2倍に増加することを明らかにした。リンパ管は筋損傷時の毛細血管新生のトリガーとして機能し、筋損傷からの回復に不可欠な存在の可能性がある。そこで本研究は、力学刺激⇒リンパ管新生⇒筋損傷回復という、これまでにない新たな切り口から有効な理学療法を探る。
本研究の目的は、筋損傷からの回復における筋内リンパ管の形態応答のメカニズムを組織学的、免疫組織学的そして生化学的に明らかにし、筋損傷におけるリンパ管の役割を解明することである。さらに、このリンパ管の役割に着目して、効果的な理学療法を探ることである。
まず、我々の開発した、可動範囲や運動速度を自由に制御できる装置を改良し、マウス前脛骨筋に対して±5％の精度で筋損傷を作製できることを確認した。そして、損傷筋線維や炎症系細胞の浸潤が多くみられる損傷４日後にリンパ管数が急激に増加し、７日後に減少し損傷前の状態に戻る事することが明らかになった。一方、毛細血管数はそれより遅れて増加することも判明した。また、内皮細胞増殖因子であるVEGF-C/-D、VEGFR-3のmRNA発現量は、リンパ管数の増加とほぼ同じ時期に高いことが判明した。すなわち、筋損傷後のリンパ管新生のメカニズムには、癌細胞増殖や他の組織損傷後と同様のメカニズムの関与が考えられた。
筋損傷からの回復促進効果が期待できる、伸長刺激を用いて、リンパ管や毛細血管の視点から検証した。伸長刺激は足関節を0.9 mNmと0.6 mNm で他動的に足関節底屈させることにより与えた。両トルクで休息5秒間を挟んで5秒間、75回を1セットとして、損傷24時間後に１セットのみ実施する条件と、それから毎日１セット実施する条件とで行った。その結果、損傷24時間後に0.6 mNmという比較的弱い伸長刺激を１セットのみ実施すると、損傷後の再生筋線維の指標といわれる中心核筋線維の平均面積が、コントロール群に対して大きい傾向にあることが判明した。なお、筋腹の深層部の 毛細血管密度の結果でのみ2日目に比べた7日目の有意に高値を示した。リンパ管の密度は全群間で有意差がなく、条件を絞った検証が必要であることが判明した。 -
Assesment of lymphedema based on protein dynamics: Fundamental study using lymphedema model rats
Grant number：23K09834 2023.4 - 2026.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Principal investigator Grant type：Competitive
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
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筋損傷に対する筋内リンパ管の役割とその役割に着目した治療戦略
Grant number：22H03440 2022.4 - 2026.3
科学研究費助成事業 基盤研究(B)
河上 敬介, 縣 信秀, 竹野 ゆかり, 紀 瑞成
Authorship：Coinvestigator(s)
これまで，筋損傷におけるリンパ管の役割は不明で，その分布すら分かっていなかった。我々は，筋内のリンパ管が他の組織と異なる大きさや分布を呈すること，そのリンパ管の数や大きさが筋損傷後の回復早期に通常の約2倍に増加することを明らかにした。一方近年，リンパ管新生は周囲組織の毛細血管新生までも誘導し筋の壊死を抑えることが報告された。よってリンパ管は，筋損傷においても毛細血管新生のトリガーとして機能し，筋再生やエネルギー供給に寄与し，筋損傷からの回復に不可欠な存在かもしれない。本研究は，力学刺激⇒リンパ管新生⇒筋損傷回復という，これまでにない新たな切り口から有効な理学療法を探る。
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Reconstructing anatomy and physiology in nursing education and creating educational guidelines
Grant number：20K10650 2020.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Fujimoto Etsuko
Authorship：Coinvestigator(s)
The guidelines were created with the aim of providing educational content that can be used in clinical practice, based on experimental research and anatomical and physiological evidence to support nursing techniques. The results are as follows:
1) Several Japanese textbooks and American textbooks were translated, and new suggestions were obtained. 2) As research-based evidence, ① "Position changes and blood pressure changes" was added to the "Encouraging patients to get out of bed" section, ② "A new technique for intramuscular injections into the deltoid muscle" was added to the "Dealing with infection" section, ③ "Movement of the epiglottis when swallowing and the timing of pushing the gastric tube forward" was added to the "Meal assistance" section, and ④ "Care for lymphedema" was incorporated from a new perspective to understand "Assisting breast cancer patients." 3) Microscopic photographs were added to show actual situations at the cellular and tissue levels. -
Sleep quality following lower extremity surgery in elderly patients
Grant number：20K10716 2020.4 - 2024.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Arita Hiromi
Authorship：Coinvestigator(s)
The purpose of this study was to investigate the sleep conditions of elderly patients who had undergone orthopedic surgery of the lower extremities from the night before surgery until one week postoperatively. Elderly patients were studied using Mattress-type sleep monitoring device (SleepscanR SL-503; Tanita Co., Tokyo) and St. Mary’s Hospital Sleep Questionnaire. Sleep patterns of patients with knee/hip surgery were showed deprivation and fragment of sleep. Sleep parameters in Lumbar spine surgery group were not significantly between before and after surgery. There was no significant difference in sleep parameters between the two groups, lumbar spine surgery and knee/hip surgery.
In the lumbar surgery group, it tended to be worse subjective sleep perception of postoperative day 6 than that before surgery. -
Grant number：20K10684 2020.4 - 2024.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Nakanishi Keisuke
Authorship：Coinvestigator(s)
In the present study, trace biogas samples from pathological and physiological edema areas in mice and healthy subjects were analyzed by gas chromatography method without setting feature targets (Experiment 1; study using a rat hindlimb lymphedema model, Experiment 2; study using a mouse tail lymphedema model, Experiment 3; Search for trace biogas components specific to physiological edema).As a result, a maximum of over 1000 features were found.
Further study is needed for finding a promising features and candidate substances. -
Grant number：19K10925 2019.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Oshima Chika
Authorship：Coinvestigator(s)
This study aimed to establish early detection and quantitative evaluation methods for upper limb and truncal lymphedema after breast cancer surgery. For upper limb lymphedema, ultrasonography, MRI, and fractal analysis were used to assess subcutaneous tissue structure. A correlation was found between fluid retention and structural complexity. Notably, some cases showed symptoms despite no fluid on MRI, suggesting fractal analysis may detect early changes undetected by conventional methods.For truncal lymphedema, a multifaceted method combining 3D scanning, MRI, and expert assessment was developed. The 3D scanner measured thickness differences accurately. All patients reported symptoms, even without MRI-confirmed fluid, highlighting the need for more sensitive assessments.These findings support improved early diagnosis and clinical application.
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Grant number：19K10795 2019.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
MAWAKI AYANA
Authorship：Coinvestigator(s)
This study aimed to clarify whether the skin surface structure, which remains poorly understood in patients with lymphedema, could be used as an indicator for evaluating the condition. Using existing magnified images, we analyzed skin furrows and ridges in patients with upper limb lymphedema. The analysis showed that the proportion of the skin ridge area tended to increase on the affected side, suggesting this may be a characteristic feature of lymphedema.
We also examined changes in skin surface structure before and after the onset of physiological edema in the lower limbs of healthy women. Results indicated that the ridge ratio in the peroneal region was higher than in other areas. These findings support the potential usefulness of magnified skin surface images for evaluating edema. Our study suggests that such imaging could provide a simple, noninvasive method to support the assessment and monitoring of lymphedema in clinical settings. -
Alterations of lymph vessels and interstitial tissuesassociated with lymphedema
Grant number：18K17458 2018.4 - 2022.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
takeno Yukari
Authorship：Principal investigator
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
The purpose of this present research was to develop nursing care to prevent fiberization after lymphedema.
A lymphedema model rat was made, and then interstitial pressure was measured by Pressure measurement catheter(Miller). Moreover, alterations of interstitial pressure was measured when manual lymph drainage or bandage was applied on it.
To drain lymph from distal to proximal in the lymphedema leg, a strongish pressure was needed. However, we couldn't find how such strong pressure causes lymph vessels and interstitial tissues for an extended period. -
Care for patients with both diabetes and secondary lymphedema
Grant number：16H05563 2016.4 - 2020.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
FUJIMOTO Etsuko
Authorship：Coinvestigator(s)
We attempted to establish a care program for breast cancer-related lymphedema in diabetic patients. We examined from various viewpoints based on the complete decongestive therapy (CDT).
MR images of the forearm revealed that fluid accumulates in ulnar side more than radial side. Therefore, it is recommended that the drainage should focus on this part. After 120 minutes of meal, it was found that blood pressure stabilize. Hence CDT should be carried out at 120 minutes after a meal. Because the evaluation using a tape measure or subjective symptoms was not sufficient, in order to understand the situation of edema, magnetic resonance imaging or ultrasonic diagnostic imaging is necessary. In self-care, it is important to visually grasp the effects of care in order to encourage patients. For this purpose, we considered to use a 3D scanner. -
Sleep of patients with analgesics/sedative management in an intensive care unit after surgery
Grant number：16K12035 2016.4 - 2020.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
ARITA HIROMI
Authorship：Coinvestigator(s)
The purpose of the present study was to elucidate the sleep conditions of patients who applied J-PAD guideline after surgery through in an ICU and general wards. Sleep parameter from 21 patients who underwent cardiac surgery, craniocervical cancer reconstructive surgery, thermotherapy of digestive cancer were analyzed. In term of sleep duration, duration of awakening, and sleep efficiency, sleep quality of patients in the ICU seemed better than those in the surgical ward after discharge from ICU. Sleep on 3-4 th night in the surgical ward was fragmented. The quality of sleep decreased. Analgesics/sedative management based on J-PAD could improve sleep quality of patients who underwent surgery in the ICU, but those in the surgical ward was disturbed when the analgesia/sedative management was discontinued.
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Study on sleep disorder of patients with Cancer-treatment-Related Lymphedema
Grant number：15K11468 2015.4 - 2019.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Oshima Chika
Authorship：Coinvestigator(s)
Multi-layer bandaging (MLB) are very effective in the management oflymphedema. However, MLB is considered to add stress to patients such as pressure and restricted movement on extremity, hence, MLB during night may disrupt their sleep.This study examined whether MLB disrupt the sleep.This study recruited 14 healthy female volunteers and six female patients with stage II lymphedema as a result of breast cancer surgery. Both of the healthy volunteer group and the patient group were required to wear a wrist actigraph for 2 weeks. In the healthy volunteer group, MLB increased only WASO on the first day but WASO recovered on the seventh day. In the patient group, MLB shorten SLAT on the seventh day, meaning to fall asleep easily.
These results suggest that wearing MLB may not reduce the quality of sleep during the night in patients with breast cancer-related lymphedema.
Social Contribution 1
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リーダーシップ研修
Role(s)：Lecturer
2022