Updated on 2024/03/18

写真a

 
URAKAWA Hiroshi
 
Organization
Nagoya University Hospital Lecturer of hospital
Title
Lecturer of hospital

Degree 1

  1. 博士(医学) ( 2011.3   名古屋大学 ) 

Research History 10

  1. Nagoya University   Nagoya University Hospital   Lecturer of hospital

    2022.4

  2. Pharmaceuticals and Medical Devices Agency

    2020.4 - 2022.3

  3. Nagoya University Hospital   Clinical Oncology and Chemotherapy   Lecturer of hospital

    2017.7 - 2020.3

  4. 名古屋大学医学部附属病院   整形外科   病院講師

    2016.4 - 2017.6

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    Country:Japan

  5. 名古屋大学大学院医学系研究科   小児集中治療学寄附講座   寄附講座講師

    2015.6 - 2016.3

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    Country:Japan

  6. 名古屋大学大学院医学系研究科   化学療法学   特任助教

    2012.7 - 2015.5

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    Country:Japan

  7. 名古屋大学医学部附属病院   整形外科   医員

    2010.4 - 2012.6

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    Country:Japan

  8. 名古屋記念病院   整形外科   医師

    2004.4 - 2010.3

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    Country:Japan

  9. 医療法人豊田会刈谷総合病院   医師

    2001.4 - 2004.3

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    Country:Japan

  10. 医療法人豊田会刈谷総合病院   研修医

    1999.4 - 2001.3

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2011.3

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    Country: Japan

  2. University of Occupational and Environmental Health, Japan   Faculty of Medicine

    - 1999.3

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    Country: Japan

Professional Memberships 3

  1. 日本整形外科学会

  2. 中部日本整形外科・災害外科学会

  3. 日本臨床腫瘍学会

 

Papers 43

  1. A randomized phase III trial of denosumab before curettage for giant cell tumor of bone. JCOG1610 Reviewed International journal

    Urakawa, H; Nagano, A; Machida, R; Tanaka, K; Kataoka, T; Sekino, Y; Nishida, Y; Takahashi, M; Kunisada, T; Kawano, M; Yoshida, Y; Takagi, T; Sato, K; Hiruma, T; Hatano, H; Tsukushi, S; Sakamoto, A; Akisue, T; Hiraoka, K; Ozaki, T

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 52 ( 9 ) page: 1021 - 1028   2022.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jjco/hyac071

    Web of Science

    PubMed

  2. Phase II trial of pazopanib in patients with metastatic or unresectable chemoresistant sarcomas: A Japanese Musculoskeletal Oncology Group study Reviewed International journal

    Urakawa, H; Kawai, A; Goto, T; Hiraga, H; Ozaki, T; Tsuchiya, H; Nakayama, R; Naka, N; Matsumoto, Y; Kobayashi, E; Okuma, T; Kunisada, T; Ando, M; Ueda, T; Nishida, Y

    CANCER SCIENCE   Vol. 111 ( 9 ) page: 3303 - 3312   2020.9

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14542

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  3. Clinical value of serum bone resorption markers for predicting clinical outcomes after use of bone modifying agents in metastatic bone tumors: A prospective cohort study Reviewed International journal

    Urakawa, H; Ando, Y; Hase, T; Kikumori, T; Arai, E; Maeda, O; Mitsuma, A; Sugishita, M; Shimokata, T; Ikuta, K; Ishiguro, N; Nishida, Y

    INTERNATIONAL JOURNAL OF CANCER   Vol. 146 ( 12 ) page: 3504 - 3515   2020.6

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ijc.32836

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  4. A randomized phase III trial of denosumab before curettage for giant cell tumor of bone: Japan Clinical Oncology Group Study JCOG1610. Reviewed International journal

    Urakawa H, Mizusawa J, Tanaka K, Eba J, Hiraga H, Kawai A, Nishida Y, Hosaka M, Iwamoto Y, Fukuda H, Ozaki T

    Japanese journal of clinical oncology   Vol. 49 ( 4 ) page: 379 - 382   2019.4

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jjco/hyz004

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  5. Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study Reviewed International journal

    Urakawa Hiroshi, Yonemoto Tsukasa, Matsumoto Seiichi, Takagi Tatsuya, Asanuma Kunihiro, Watanuki Munenori, Takemoto Akira, Naka Norifumi, Matsumoto Yoshihiro, Kawai Akira, Kunisada Toshiyuki, Kubo Tadahiko, Emori Makoto, Hiraga Hiroaki, Hatano Hiroshi, Tsukushi Satoshi, Nishida Yoshihiro, Akisue Toshihiro, Morii Takeshi, Takahashi Mitsuru, Nagano Akihito, Yoshikawa Hideki, Sato Kenji, Kawano Masanori, Hiraoka Koji, Tanaka Kazuhiro, Iwamoto Yukihide, Ozaki Toshifumi

    WORLD JOURNAL OF SURGICAL ONCOLOGY   Vol. 16 ( 1 ) page: 160   2018.8

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12957-018-1459-6

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  6. Potential drug interactions between pazopanib and proton pump inhibitors/potassium-competitive acid blockers in patients with soft tissue sarcoma Reviewed International coauthorship International journal

    Liang, Y; Maeda, O; Shimokata, T; Yokota, K; Koike, H; Sakai, T; Ikuta, K; Urakawa, H; Nishida, Y; Akiyama, M; Ando, Y

    INTERNATIONAL CANCER CONFERENCE JOURNAL   Vol. 13 ( 1 ) page: 63 - 67   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s13691-023-00638-2

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  7. Clinical results of active surveillance for extra-abdominal desmoid-type fibromatosis Reviewed International journal

    Sakai, T; Nishida, Y; Ito, K; Ikuta, K; Urakawa, H; Koike, H; Imagama, S

    CANCER MEDICINE   Vol. 12 ( 5 ) page: 5245 - 5254   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/cam4.5329

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  8. Hyaluronan in articular cartilage: Analysis of hip osteoarthritis and osteonecrosis of femoral head Reviewed International coauthorship International journal

    Zhang, JR; Nishida, Y; Koike, H; Ito, K; Zhuo, LS; Nishida, K; Kimata, K; Ikuta, K; Sakai, T; Urakawa, H; Seki, T; Imagama, S

    JOURNAL OF ORTHOPAEDIC RESEARCH   Vol. 41 ( 2 ) page: 307 - 315   2023.2

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  9. Surgical Treatment and Complications of Deep-Seated Nodular Plexiform Neurofibromas Associated with Neurofibromatosis Type 1 Reviewed International journal

    Ikuta, K; Nishida, Y; Sakai, T; Koike, H; Ito, K; Urakawa, H; Imagama, S

    JOURNAL OF CLINICAL MEDICINE   Vol. 11 ( 19 )   2022.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/jcm11195695

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  10. Current management of giant-cell tumor of bone in the denosumab era Invited Reviewed International journal

    Nagano, A; Urakawa, H; Tanaka, K; Ozaki, T

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 52 ( 5 ) page: 411 - 416   2022.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jjco/hyac018

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  11. Diffusion-Weighted Magnetic Resonance Imaging Improves the Accuracy of Differentiation of Benign from Malignant Peripheral Nerve Sheath Tumors Reviewed International journal

    Koike, H; Nishida, Y; Ito, S; Shimoyama, Y; Ikuta, K; Urakawa, H; Sakai, T; Shimizu, K; Ito, K; Imagama, S

    WORLD NEUROSURGERY   Vol. 157   page: E207 - E214   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.wneu.2021.09.130

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  12. Less-invasive fascia-preserving surgery for abdominal wall desmoid Reviewed International journal

    Nishida, Y; Hamada, S; Sakai, T; Ito, K; Ikuta, K; Urakawa, H; Koike, H; Imagama, S

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 19379   2021.9

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  13. Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study Reviewed International journal

    Ota, T; Nishida, Y; Ikuta, K; Tsukushi, S; Yamada, K; Kozawa, E; Urakawa, H; Imagama, S

    SCIENTIFIC REPORTS   Vol. 11 ( 1 ) page: 17384   2021.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-021-96795-6

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  14. Overexpression of KIAA1199, a novel strong hyaluronidase, is a poor prognostic factor in patients with osteosarcoma Reviewed International journal

    Ito, K; Nishida, Y; Ikuta, K; Urakawa, H; Koike, H; Sakai, T; Zhang, JR; Shimoyama, Y; Imagama, S

    JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH   Vol. 16 ( 1 ) page: 439   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s13018-021-02590-4

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  15. A Novel Technique to Lengthen the Reverse Latissimus Dorsi Muscle Flap Arc Reviewed International journal

    Takanari, K; Nakamura, Y; Uchibori, T; Nakamura, R; Ebisawa, K; Kambe, M; Urakawa, H; Nishida, Y; Kamei, Y

    PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN   Vol. 9 ( 7 ) page: e3525   2021.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/GOX.0000000000003525

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  16. Limitations and benefits of FDG-PET/CT in NF1 patients with nerve sheath tumors: A cross-sectional/longitudinal study Reviewed International journal

    Nishida, Y; Ikuta, K; Ito, S; Urakawa, H; Sakai, T; Koike, H; Ito, K; Imagama, S

    CANCER SCIENCE   Vol. 112 ( 3 ) page: 1114 - 1122   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14802

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  17. PhaseIIclinical trial of pazopanib for patients with unresectable or metastatic malignant peripheral nerve sheath tumors Reviewed International journal

    Nishida, Y; Urakawa, H; Nakayama, R; Kobayashi, E; Ozaki, T; Ae, K; Matsumoto, Y; Tsuchiya, H; Goto, T; Hiraga, H; Naka, N; Takahashi, S; Ando, Y; Ando, M; Kuwatsuka, Y; Hamada, S; Ueda, T; Kawai, A

    INTERNATIONAL JOURNAL OF CANCER   Vol. 148 ( 1 ) page: 140 - 149   2021.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ijc.33201

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  18. Chemotherapy for biliary tract cancer: real-world experience in a single institute Reviewed International journal

    Maeda, O; Ebata, T; Shimokata, T; Matsuoka, A; Inada-Inoue, M; Morita, S; Takano, Y; Urakawa, H; Miyai, Y; Sugishita, M; Mitsuma, A; Ando, M; Mizuno, T; Nagino, M; Ando, Y

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 4 ) page: 725 - 733   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.82.4.725

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  19. Desmoid with biweekly methotrexate and vinblastine shows similar effects to weekly administration: A phase II clinical trial Reviewed International journal

    Nishida, Y; Hamada, S; Urakawa, H; Ikuta, K; Sakai, T; Koike, H; Ito, K; Emoto, R; Ando, Y; Matsui, S

    CANCER SCIENCE   Vol. 111 ( 11 ) page: 4187 - 4194   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14626

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  20. Solitary fibrous tumor/hemangiopericytoma treated with temozolomide plus bevacizumab: a report of four cases and literature review Reviewed International journal

    Maeda, O; Ohka, F; Maesawa, S; Matsuoka, A; Shimokata, T; Mitsuma, A; Urakawa, H; Nakamura, S; Shimoyamas, Y; Nakaguro, SM; Wakabayashi, T; Ando, Y

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 4 ) page: 631 - 644   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.18999/nagjms.82.4.631

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  21. Functional evaluation following deltoid muscle resection in patients with soft tissue sarcoma Reviewed International journal

    Hamada, S; Nishida, Y; Takanari, K; Ota, T; Urakawa, H; Ikuta, K; Sakai, T; Tsukushi, S; Kamei, Y; Ishiguro, N

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 50 ( 7 ) page: 772 - 778   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jjco/hyaa039

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  22. Phase II clinical trial of pazopanib for patients with unresectable or metastatic malignant peripheral nerve sheath tumors. International journal

    Nishida, Y; Urakawa, H; Nakayama, R; Ozaki, T; Ae, K; Matsumoto, Y; Ando, Y; Kuwatsuka, Y; Ueda, T; Kawai, A

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 38 ( 15 )   2020.5

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  23. MRI characteristics predict the efficacy of meloxicam treatment in patients with desmoid-type fibromatosis Reviewed International journal

    Shimizu, K; Hamada, S; Sakai, T; Ito, S; Urakawa, H; Arai, E; Ikuta, K; Koike, H; Ishiguro, N; Nishida, Y

    JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY   Vol. 63 ( 6 ) page: 751 - 757   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/1754-9485.12940

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  24. Recent Topics on Primary Bone and Soft Tissue Tumors and Metastatic Bone Tumors International journal

    Urakawa, H

    ANNALS OF ONCOLOGY   Vol. 30   page: 62 - 62   2019.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (conference, symposium, etc.)  

    DOI: 10.1093/annonc/mdz368

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  25. Low-dose chemotherapy with methotrexate and vinblastine for patients with refractory desmoid tumors: A second report of relationship between efficacy and various factors. Reviewed International journal

    Nishida, Y; Sakai, T; Shimizu, K; Urakawa, H; Arai, E; Ikuta, K; Ando, Y; Ishiguro, N

    JOURNAL OF CLINICAL ONCOLOGY   Vol. 37 ( 15 )   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    Web of Science

  26. A randomized phase III study of denosumab before curettage for giant cell tumor of bone: Japan Clinical Oncology Group study JCOG1610

    Urakawa, H; Mizusawa, J; Tanaka, K; Eba, J; Hiraga, H; Hosaka, M; Kawai, A; Nakatani, F; Kobayashi, E; Nishida, Y; Okamoto, T; Matsunobu, T; Iwamoto, Y; Fukuda, H; Ozaki, T

    ANNALS OF ONCOLOGY   Vol. 29   2018.10

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    Authorship:Lead author   Publishing type:Research paper (conference, symposium, etc.)  

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  27. Outpatient chemotherapy for patients with unresectable or metastatic bone sarcomas International journal

    Urakawa, H; Nishida, Y; Mitsuma, A; Maeda, O; Sugishita, M; Shimokata, T; Mizutani, T; Arai, E; Ikuta, K; Hamada, S; Ota, T; Ishiguro, N; Ando, Y

    ANNALS OF ONCOLOGY   Vol. 29   2018.10

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    Authorship:Lead author   Language:English   Publishing type:Research paper (conference, symposium, etc.)  

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  28. Predictors of complications in heat-treated autograft reconstruction after intercalary resection for malignant musculoskeletal tumors of the extremity Reviewed International journal

    Ikuta Kunihiro, Nishida Yoshihiro, Sugiura Hideshi, Tsukushi Satoshi, Yamada Kenji, Urakawa Hiroshi, Arai Eisuke, Hamada Shunsuke, Ishiguro Naoki

    JOURNAL OF SURGICAL ONCOLOGY   Vol. 117 ( 7 ) page: 1469 - 1478   2018.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jso.25028

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  29. Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification. Reviewed International journal

    Yamashita K, Kohashi K, Yamada Y, Ishii T, Nishida Y, Urakawa H, Ito I, Takahashi M, Inoue T, Ito M, Ohara Y, Oda Y, Toyokuni S

    Histopathology   Vol. 72 ( 5 ) page: 729 - 738   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/his.13421

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  30. Single metastasis of myxoid liposarcoma from the thigh to thyroid gland: a case report Reviewed International journal

    Urakawa Hiroshi, Nakanishi Kenichi, Arai Eisuke, Ikuta Kunihiro, Hamada Shunsuke, Ota Takehiro, Ishiguro Naoki, Nishida Yoshihiro

    WORLD JOURNAL OF SURGICAL ONCOLOGY   Vol. 16 ( 1 ) page: 71   2018.3

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12957-018-1370-1

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  31. Real-world experience with FOLFIRINOX and gemcitabine plus nab-paclitaxel in the treatment of pancreatic cancer in Japan International journal

    Maeda O., Yokoyama Y., Yamaguchi J., Ota A., Matsuoka A., Morita S., Inoue M., Mizutani T., Shimokata T., Urakawa H., Mitsuma A., Nagino M., Ando Y.

    ANNALS OF ONCOLOGY   Vol. 28   page: 69 - 69   2017.11

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  32. Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status.

    Yamashita K, Kohashi K, Yamada Y, Nishida Y, Urakawa H, Oda Y, Toyokuni S

    Human pathology   Vol. 63   page: 63-69   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.humpath.2017.02.007

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  33. Antitumor effects of 4-methylumbelliferone, a hyaluronan synthesis inhibitor, on malignant peripheral nerve sheath tumor Reviewed International coauthorship International journal

    Ikuta Kunihiro, Ota Takehiro, Zhuo Lisheng, Urakawa Hiroshi, Kozawa Eiji, Hamada Shunsuke, Kimata Koji, Ishiguro Naoki, Nishida Yoshihiro

    INTERNATIONAL JOURNAL OF CANCER   Vol. 140 ( 2 ) page: 469 - 479   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ijc.30460

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  34. Neoadjuvant and adjuvant chemotherapy with doxorubicin and ifosfamide for bone sarcomas in adult and older patients.

    Urakawa H, Tsukushi S, Sugiura H, Yamada K, Yamada Y, Kozawa E, Arai E, Futamura N, Ishiguro N, Nishida Y.

    Oncol Lett.   Vol. 8 ( 6 ) page: 2485-2488   2014.12

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  35. Clinical factors affecting pathological fracture and healing of unicameral bone cysts.

    Urakawa H, Tsukushi S, Hosono K, Sugiura H, Yamada K, Yamada Y, Kozawa E, Arai E, Futamura N, Ishiguro N, Nishida Y.

    BMC Musculoskelet Disord.   Vol. 15   page: 159   2014.5

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  36. 抗がん剤外来治療コンセプトシート2013】 外来での有害事象管理 RANKL抗体医薬による低カルシウム血症

    浦川浩, 安藤雄一

    医学のあゆみ   Vol. 246 ( 9 ) page: 812-817   2013.8

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    Language:Japanese  

  37. Metastasis of osteosarcoma to stomach made clinically evident by hematemesis: a case report.

    Urakawa H, Tsukushi S, Tsurudome I, Hirata A, Arai E, Kozawa E, Futamura N, Miyahara R, Ishiguro N, Nishida Y.

    World J Surg Oncol.   Vol. 11   page: 48   2013.2

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  38. Therapeutic potential of hyaluronan oligosaccharides for bone metastasis of breast cancer.

    Urakawa H, Nishida Y, Knudson W, Knudson CB, Arai E, Kozawa E, Futamura N, Wasa

    J Orthop Res.   Vol. 30 ( 4 ) page: 662-72   2012.4

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  39. nhibition of hyaluronan synthesis in breast cancer cells by 4-Methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo.

      Vol. 130 ( 2 ) page: 454-66   2012.1

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  40. Glanzmann thrombasthenia detected because of knee hemarthrosis: a case report.

    Urakawa H, Nishida Y, Tsukushi S, Katsumi A, Ishiguro N.

    J Pediatr Orthop B.   Vol. 19 ( 6 ) page: 521-3   2010.11

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  41. Vocabulary IDO

    浦川浩, 西田佳弘

    整形外科   Vol. 60 ( 13 ) page: 1382   2009.12

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    Language:Japanese  

  42. Cyclooxygenase-2 overexpression predicts poor survival in patients with high-grade extremity osteosarcoma: a pilot study.

    Urakawa H, Nishida Y, Naruse T, Nakashima H, Ishiguro N.

    Clin Orthop Rel Res.   Vol. 467 ( 11 ) page: 2932-8   2009.11

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  43. Prognostic value of indoleamine 2, 3-dioxygenase expression in high grade osteosarcoma.

    Urakawa H, Nishida Y, Nakashima H, Shimoyama Y, Nakamura S, Ishiguro N.

    Clin Exp Metastasis.   Vol. 26 ( 8 ) page: 1005-12   2009

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Presentations 34

  1. Postoperative brain metastases in soft tissue sarcomas International conference

    Urakawa H, Tsukushi S, Kozawa E, Ikuta K, Hamada S, Ishiguro N, Nishida Y

    19th Annual meeting Connective Tissue Oncology society  

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    Event date: 2014.10

    Language:English   Presentation type:Poster presentation  

    Country:Germany  

  2. 単発性骨転移臨床成績の検討

    浦川浩, 西田佳弘, 筑紫聡, 満間綾子, 杉下美保子, 下方智也, 小澤英史, 新井英介, 二村尚久, 安藤雄一, 石黒直樹

    第47回日本整形外科学会骨・軟部腫瘍学術集会 

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    Event date: 2014.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:大阪   Country:Japan  

  3. 骨転移患者におけるゾレドロン酸投与後腎障害の検討

    浦川浩, 筑紫聡, 満間綾子, 杉下美保子, 下方智也, 小澤英史, 新井英介, 二村尚久, 安藤雄一, 石黒直樹, 西田佳弘

    第87回日本整形外科学会学術総会 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸   Country:Japan  

  4. 上腕骨発生孤立性骨嚢腫の治療成績に影響する因子の検討

    浦川浩, 筑紫聡, 細野幸三, 杉浦英志, 山田健志, 山田芳久, 小澤英史, 新井英介, 二村尚久, 石黒直樹, 西田佳弘

    第87回日本整形外科学会学術総会 

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    Event date: 2014.5

    Language:Japanese   Presentation type:Poster presentation  

    Venue:神戸   Country:Japan  

  5. Prognostic impact of trunk location in patients with non-small round cell soft tissue sarcoma International conference

    Urakawa H, Tsukushi S, Kozawa E, Arai E, Futamura N, Ishiguro N, Nishida Y.

    The 10th Asia Pacific Musculoskeletal Tumor Society Meeting,  

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    Event date: 2014.4

    Language:English   Presentation type:Oral presentation (general)  

    Country:Australia  

  6. Clinical factors affecting healing of unicameral bone cysts in humerus International conference

    Urakawa H, Tsukushi S, Hosono K, Sugiura H, Yamada K, Yamada Y, Kozawa E, Arai E, Futamura N, Ishiguro N, Nishida Y.

    The 10th Asia Pacific Musculoskeletal Tumor Society Meeting,  

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    Event date: 2014.4

    Language:English   Presentation type:Poster presentation  

    Country:Australia  

  7. Perioperative chemotherapy with doxorubicin and ifosfamide for bone sarcomas in adult and older patients International conference

    Urakawa H, Tsukushi S, Sugiura H, Yamada K, Yamada Y, Arai E, Kozawa E, Futamura N, Ishiguro N, Nishida Y.

    18th Annual meeting Connective Tissue Oncology Society , 

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    Event date: 2013.10 - 2013.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  8. 中高年発症骨原発肉腫に対するイホスファミド/ドキソルビシン補助化学療法の検討

    浦川浩, 筑紫聡, 新井英介, 小澤英史, 石黒直樹, 西田佳弘

    第121回中部日本整形外科災害外科学会・学術集会 

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    Event date: 2013.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  9. 骨転移症例における骨関連事象に関連する因子の検討

    浦川浩, 西田佳弘, 筑紫聡, 満間綾子, 杉下美保子, 下方智也, 新井英介, 小澤英史, 二村尚久, 石黒直樹, 安藤雄一

    第46回日本整形外科学会骨・軟部腫瘍学術集会 

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    Event date: 2013.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  10. 左下腿近位骨腫瘍の1例

    浦川浩, 西田佳弘, 筑紫聡, 新井英介, 小澤英史, 二村尚久, 石黒直樹, 下山芳江, 高原大志, 鈴木優香, 佐藤啓, 立松明子, 宮田友子, 加藤省一, 島田聡子, 大橋明子, 中村栄男

    第75回東海骨軟部腫瘍研究会 

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    Event date: 2012.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  11. ヒアルロン酸を標的とした乳癌骨転移治療 ヒアルロン酸合成阻害剤による治療効果

    浦川浩, 西田佳弘, 和佐潤志, 新井英介, 小澤英史, 石黒直樹

    第119回中部日本整形外科災害外科学会・学術集会 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福井   Country:Japan  

  12. Factors Correlated With The Pathological Fracture And Clinical Outcome In Patients With Unicameral Bone Cyst. International conference

    Urakawa H, Hosono K, Sugiura H, Nakashima H, Yamada Y, Tsukushi S, Arai E, Kozawa E, Futamura N, Ishiguro N, Nishida Y.

    The 9th Asia Pacific Musculoskeletal Tumor Society Meeting,  

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    Event date: 2012.9

    Language:English   Presentation type:Oral presentation (general)  

    Country:Malaysia  

  13. 右大腿骨骨腫瘍の1例

    浦川浩, 西田佳弘, 筑紫聡, 新井英介, 小澤英史, 二村尚久, 石黒直樹, 宮田友子, 高原大志, 鈴木優香, 佐藤啓, 立松明子, 加藤省一, 島田聡子, 大橋明子, 下山芳江, 中村栄男

    第74回東海骨軟部腫瘍研究会 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  14. 吐血により顕在化した骨肉腫胃転移の1例

    浦川浩, 西田佳弘, 筑紫聡, 新井英介, 小澤英史, 二村尚久, 石黒直樹

    第45回日本整形外科学会骨・軟部腫瘍学術集会  

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    Event date: 2012.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  15. 軟部肉腫における発症から診断までの期間と予後との検討

    浦川浩, 西田佳弘, 筑紫聡, 新井英介, 小澤英史, 二村尚久, 石黒直樹

    第45回日本整形外科学会骨・軟部腫瘍学術集会 

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    Event date: 2012.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:東京   Country:Japan  

  16. 孤立性骨嚢腫における病的骨折発症および治療成績に影響する因子の検討

    浦川浩, 西田佳弘, 細野幸三, 杉浦英志, 中島浩敦, 山田芳久, 筑紫聡, 新井英介, 小澤英史, 二村尚久, 石黒直樹

    第85回日本整形外科学会学術総会 

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    Event date: 2012.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  17. Therapeutic Potential of Hyaluronan Oligosaccharides for Bone Metastasis of Breast Cancer International conference

    Urakawa H, Nishida Y, Arai E, Kozawa E, Futamura N, Ishiguro N.

    2012 Annual Meeting of American Academy of Orthopaedic Surgeons,  

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    Event date: 2012.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  18. ヒアルロン酸を標的とした乳癌骨転移治療 低分子ヒアルロン酸オリゴ糖による治療効果

    浦川浩, 西田佳弘, 和佐潤志, 新井英介, 小澤英史, 二村尚久, 石黒直樹

    第26回日本整形外科学会基礎学術集会 

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    Event date: 2011.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:前橋   Country:Japan  

  19. Factors influencing soft tissue complications after resection of soft tissue sarcomas arising in lower leg International conference

    Urakawa H, Nishida Y, Nakashima H, Tsukushi S, Arai E, Kamei Y, Toriyama K, Ishiguro N.

    International Society of Limb Salvage 16th General Meeting,  

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    Event date: 2011.9

    Language:English   Presentation type:Poster presentation  

    Country:China  

  20. 脊索腫を除く骨・軟部肉腫に対する重粒子線治療成績の検討

    浦川浩, 西田佳弘, 杉浦英志, 中島浩敦, 山田芳久, 筑紫聡, 和佐潤志, 今井礼子, 鎌田正, 石黒直樹

    第44回日本整形外科学会骨・軟部腫瘍学術集会 

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    Event date: 2011.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都   Country:Japan  

  21. ヘルニア手術を行われた鼡径部発生軟部肉腫の検討

    浦川浩, 西田佳弘, 中島浩敦, 山田芳久, 筑紫聡, 石黒直樹

    第116回中部日本整形外科災害外科学会・学術集会 

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    Event date: 2011.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:高知   Country:Japan  

  22. Hyaluronan Oligosaccharides Inhibit Tumorigenicity of Breast Cancer Cells in Vitro and Metastatic Lesions of Bone in Vivo. International conference

    Urakawa H, Nishida Y, Wasa J, Arai E, Suzuki Y, Hosono K, Kozawa E, Futamura N, Ishiguro N.

    2011 Annual Meeting of Orthopedic Research Society,  

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    Event date: 2011.1

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  23. 右上腕骨骨腫瘍の1例

    浦川浩, 西田佳弘, 筑紫聡, 和佐潤志, 石黒直樹, 下山芳江, 村上善子, 立松明子, 宮田友子, 加藤省一, 中村栄男

    第70回東海骨軟部腫瘍研究会 

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    Event date: 2010.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  24. 乳癌および乳癌骨転移に対するヒアルロン酸合成阻害剤の抗腫瘍効果

    浦川浩, 西田佳弘, 和佐潤志, 新井英介, 鈴木喜貴, 細野幸三, 小澤英史, 二村尚久, 石黒直樹

    第25回日本整形外科学会基礎学術集会 

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    Event date: 2010.10

    Language:Japanese   Presentation type:Poster presentation  

    Venue:京都   Country:Japan  

  25. 右肘関節腫瘍の1例

    浦川浩, 西田佳弘, 筑紫聡, 和佐潤志, 石黒直樹, 村上善子, 立松明子, 宮田友子, 加藤省一, 下山芳江, 中村栄男

    第69回東海骨軟部腫瘍研究会 

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    Event date: 2010.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  26. 下腿軟部肉腫に対する患肢温存術後合併症に影響する因子の検討

    浦川浩,西田佳弘,中島浩敦,筑紫聡,紫藤洋二, 和佐潤志,新井英介,小澤英史,鳥山和宏,亀井譲, 石黒直樹

    第43回日本整形外科学会骨・軟部腫瘍学術集会 

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    Event date: 2010.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  27. Inhibition of hyaluronan synthesis in breast cancer cells suppresses tumorigenicity in vitro and metastatic lesion of bone in vivo. International conference

    Urakawa H, Nishida Y, Wasa J, Arai E, Zhuo L, Kimata K, Kozawa E, Futamura N, Ishiguro N.

    8th International Conference on Hyaluronan,  

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    Event date: 2010.6

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

  28. 左鼠径部軟部腫瘍の1例

    浦川浩, 西田佳弘, 筑紫聡, 紫藤洋二, 和佐潤志, 石黒直樹, 村上善子, 下山芳江,中村栄男

    第68回東海骨軟部腫瘍研究会 

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    Event date: 2010.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  29. 骨肉腫におけるindoleamine 2,3-dioxygenase(IDO)の発現解析

    浦川浩, 西田佳弘, 成瀬隆裕, 鈴木喜貴, 内堀充敏, 中島浩敦, 新井英介, 下山芳江, 中村栄男, 石黒直樹

    第114回中部日本整形外科災害外科学会・学術集会 

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    Event date: 2010.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  30. Suppression of hyaluronan synthesis in breast cancer cells demonstrates anti-tumor effects both in vitro and in vivo. International conference

    Urakawa H, Nishida Y, Wasa J, Arai E, Suzuki Y, Hosono K, Kozawa E, Ishiguro N.

    The 56th Annual Meeting of Orthopedic Research Society,  

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    Event date: 2010.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  31. 膝関節血腫により発見された血小板無力症の1例

    浦川浩, 西田佳弘, 筑紫聡, 紫藤洋二, 和佐潤志, 小澤英史, 新井英介, 石黒直樹, 勝見章

    第217回整形外科集談会東海地方会 

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    Event date: 2009.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:名古屋   Country:Japan  

  32. 骨肉腫肺転移巣におけるCOX-2発現と予後との検討

    浦川浩, 西田佳弘, 筑紫聡, 紫藤洋二, 和佐潤志, 新井英介, 石黒直樹

    第42回日本整形外科学会骨・軟部腫瘍学術集会 

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    Event date: 2009.7

    Language:Japanese   Presentation type:Poster presentation  

    Venue:横浜   Country:Japan  

  33. Prognostic Value of Indoleamine 2, 3-Dioxygenase Expression in High Grade Osteosarcoma. International conference

    Urakawa H, Nishida Y, Uchibori M, Nakashima H, Ishiguro N.

    The 55th Annual Meeting of Orthopedic Research Society,  

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    Event date: 2009.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  34. 骨肉腫におけるCOX-2発現について

    浦川浩, 西田佳弘, 中島浩敦, 成瀬隆裕, 鈴木喜貴, 筑紫聡, 内堀充敏, 山田芳久, 紫藤洋二, 新井英介, 中村栄男, 石黒直樹

    第41回日本整形外科学会骨・軟部腫瘍学術集会 

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    Event date: 2008.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:浜松   Country:Japan  

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KAKENHI (Grants-in-Aid for Scientific Research) 8

  1. Fundamental research for the application of effective combination therapy of sarcomatoid kidney cancer to bone and soft tissue sarcoma

    Grant number:23K08696  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

  2. Study of novel tumor immunotherapy by modulating extracellular matrix of advanced bone and soft tissue sarcoma

    Grant number:17K10963  2017.4 - 2020.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    URAKAWA HIROSHI

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

    To clarify the relationship between tumor immunity and extracellular matrix / receptor / intracellular signal network mediated by hyaluronan and to establish new immunotherapy targeting in bone and soft tissue sarcoma, we evaluated the relationship between immune checkpoint molecules and hyaluronan network in bone and soft tissue sarcoma. Abundant extracellular matrix was observed in bone and soft tissue sarcoma cells, and a certain relationship between extracellular matrix/ receptor / intracellular signal network and immune checkpoint molecules was observed. Abundant expression of hyaluronan was observed in bone and soft tissue sarcoma tumor tissue, and the immune cell infiltration and immune checkpoint molecule expression were observed in certain type of sarcomas.

  3. The role of cathepsin K in the bone and lung metastases

    Grant number:15K10438  2015.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    KOZAWA EIJI, YOSHIDA Masahiro, HAYASHI Takuma

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    CatK synthesized by osteoclasts and/or tumor cells, tumor microenvironmental macrophage/fibroblasts to be an obvious candidate for a key enzyme involved in the destruction of bone matrix. To establish a murine bone metastasis model, a needle with syringe was used to inject MDA-MB-231 cells and Lewis lung cancer cells into the tibia of mice. Osteolytic lesions progressed markedly at tibia of mice. Scion image analysis revealed that the size of the osteolytic increased from 2 to 4 weeks. The expansion of bone lytic areas of tibia with Lewis lung cancer progressed rapidly for 2 weeks. Histological stain for bone tumor was performed.
    The sample included 50 patients with lung tumors and 19 patients with musculoskeletal tumors. The overall 5-year survival rate of the patients was 57.7%. Pre-operative MRI evaluation is helpful to determine whether tumors should be resected with adjacent bone or not.

  4. Clinical significance of sarcopenia in cancer chemotherapy

    Grant number:26460626  2014.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ando Yuichi

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    The aim of this study is investigated sarcopenia in cancer patients who underwent cancer chemotherapy in order to test the hypothesis that those patients with sarcopenia are more likely to experience severe toxicity and then poorly tolerate the treatment. First, we retrospectively analyzed the change of skeletal muscle mass in patients treated with an mTOR inhibitor and reported that the muscle mass was significantly reduced by treatment. Subsequently, an observational study was conducted to prospectively evaluate sarcopenia up to for 6 months in cancer patients who received a kinase inhibitor containing mTOR inhibitor. Of the 28 patients enrolled, 17 and 7 patients completed the 6-month and 3-month follow-ups, respectively. Final analysis of the results is in progress.

  5. Image-guided cryoablation for palliative therapy of skeletal metastases.

    Grant number:26462260  2014.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Tsukushi Satoshi, YOSHIDA Masahiro, HAYASHI Takuma, HASEGAWA Hiroaki, SUZUKI Syuichiro

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    Authorship:Coinvestigator(s)  Grant type:Competitive

    The aim of this study was to investigate local control of in non-small round cell soft tissue sarcomas.The overall survival rates at 5 years were 85.7%.The local recurrence-free survival rates at 5 years were 89.8% (positive margin: 72.5%, margin of 2 mm or less: 60.6%). In the univariate analysis size, depth, histological grade and positive margin were significant unfavorable prognostic factors for local recurrence free survival. In multivariate analyses, we showed that positive margin and histological grade were significant independent predictors of local recurrence free survival.Positive margin and histological grade were important prognostic factors for local recurrence. Close margin (2 mm or less) in the longitudinal direction was associated with a high risk of local recurrence.The reach of the local treatment should be decided based on these factors.

  6. Establishment of bone metastasis treatment by regulating hyaluronan network and osteoclast

    Grant number:26462261  2014.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Urakawa Hiroshi

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\4940000 ( Direct Cost: \3800000 、 Indirect Cost:\1140000 )

    Bone metastases impair the quality of patients with malignancies. We focused on the co-effect of regulation of hyaluronan (HA) and bone modifying agents. We investigated the effects of 4-methylumbelliferone (MU) and/or bone modifying agents on HA expression in breast and lung cancer cell lines in addition to their tumorigenicity in vitro and in vivo. MU or zoledronic acid treatment individually suppressed proliferation, migration and invasion of breast and lung cancer cell lines, and combination treatment of MU and zoledronic acid showed synergistic effects. Combination therapy showed additive inhibitory effects on metastatic bone lesions in vivo, which paralleled the inhibition of HA accumulation by MU, and inhibition of osteoclastogenesis. These data suggest that inhibition of HA synthesis is a promising novel therapeutic candidate for bone metastasis in addition to bone modifying agents.

  7. ヒアルロン酸ネットワークと破骨細胞制御による骨転移治療の確立

    2014.4 - 2017.3

    科学研究費補助金  基盤研究(C)

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    Authorship:Principal investigator 

  8. 細胞外マトリックス制御による骨軟部肉腫の分子標的治療薬増感法の開発

    2012.4 - 2015.3

    科学研究費補助金  若手研究(B)

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    Authorship:Principal investigator 

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