A preliminary study of rapid-fire high-throughput metabolite analysis using nano-flow injection/Q-TOFMS

Taki, K; Noda, S; Hayashi, Y; Tsuchihashi, H; Ishii, A; Zaitsu, K

ANALYTICAL AND BIOANALYTICAL CHEMISTRY   Vol. 412 ( 17 ) page： 4127 - 4134   2020.7

Short-term high-fat diet intake leads to exacerbation of concanavalin A-induced liver injury through the induction of procoagulation state

Nanizawa Eri, Tamaki Yuki, Sono Reika, Miyashita Rintaro, Hayashi Yumi, Kanbe Ayumu, Ito Hiroyasu, Ishikawa Tetsuya

BIOCHEMISTRY AND BIOPHYSICS REPORTS   Vol. 22   page： 100736   2020.7

In utero exposure to di(2-ethylhexyl)phthalate suppresses blood glucose and leptin levels in the offspring of wild-type mice.

Hayashi Y, Ito Y, Naito H, Tamada H, Yamagishi N, Kondo T, Ishikawa T, Gonzalez FJ, Nakajima T

Toxicology   Vol. 415   page： 49 - 55   2019.3

Intact metabolite profiling of mouse brain by probe electrospray ionization/triple quadrupole tandem mass spectrometry (PESI/MS/MS) and its potential use for local distribution analysis of the brain (vol 983, pg 160, 2017)

Hayashi Yumi, Zaitsu Kei, Murata Tasuku, Ohara Tomomi, Moreau Stephane, Kusano Maiko, Tanihata Hiroshi, Tsuchihashi Hitoshi, Ishii Akira, Ishikawa Tetsuya

ANALYTICA CHIMICA ACTA   Vol. 1031   page： 196 - 196   2018.11

Metabolome analysis of the serotonin syndrome rat model: Abnormal muscular contraction is related to metabolic alterations and hyper-thermogenesis

Zaitsu Kei, Noda Saki, Iguchi Akira, Hayashi Yumi, Ohara Tomomi, Kimura Yuya, Koketsu Yuta, Kosaki Tomoko, Kusano Maiko, Sato Takako, Ishikawa Tetsuya, Tsuchihashi Hitoshi, Suzuki Koichi, Ishii Akira

LIFE SCIENCES   Vol. 207   page： 550-561   2018.8

In Vivo Real-Time Monitoring System Using Probe Electrospray Ionization/Tandem Mass Spectrometry for Metabolites in Mouse Brain

Zaitsu Kei, Hayashi Yumi, Murata Tasuku, Yokota Kazumi, Ohara Tomomi, Kusano Maiko, Tsuchihashi Hitoshi, Ishikawa Tetsuya, Ishii Akira, Ogata Koretsugu, Tanihata Hiroshi

ANALYTICAL CHEMISTRY   Vol. 90 ( 7 ) page： 4695-4701   2018.4

Bile acid detoxifying enzymes limit susceptibility to liver fibrosis in female SHRSP5/Dmcr rats fed with a high-fat-cholesterol diet

Yetti Husna, Naito Hisao, Yuan Yuan, Jia Xiaofang, Hayashi Yumi, Tamada Hazuki, Kitamori Kazuya, Ikeda Katsumi, Yamori Yukio, Nakajima Tamie

PLOS ONE   Vol. 13 ( 2 ) page： e0192863   2018.2

Fatal intoxication by 5F-ADB and diphenidine: Detection, quantification, and investigation of their main metabolic pathways in humans by LC/MS/MS and LC/Q-TOFMS

Kusano Maiko, Zaitsu Kei, Taki Kentaro, Hisatsune Kazuaki, Nakajima Jun'ichi, Moriyasu Takako, Asano Tomomi, Hayashi Yumi, Tsuchihashi Hitoshi, Ishii Akira

DRUG TESTING AND ANALYSIS   Vol. 10 ( 2 ) page： 284-293   2018.2

Intact metabolite profiling of mouse brain by probe electrospray ionization/triple quadrupole tandem mass spectrometry (PESI/MS/MS) and its potential use for local distribution analysis of the brain

Hayashi Yumi, Zaitsu Kei, Murata Tasuku, Ohara Tomomi, Moreau Stephane, Kusano Maiko, Tanihata Hiroshi, Tsuchihashi Hitoshi, Ishii Akira, Ishikawa Tetsuya

ANALYTICA CHIMICA ACTA   Vol. 983   page： 160-165   2017.8

Intact metabolite profiling of mouse brain by probe electrospray ionization/triple quadrupole tandem mass spectrometry (PESI/MS/MS) and its potential use for local distribution analysis of the brain. Reviewed

HAYASHI Yumi, ZAITSU Kei, MURATA Tasuku, OHARA Tomomi, MOREAU Stéphane, KUSANO Maiko, TANIHATA Hiroshi, TSUCHIHASHI Hitoshi, ISHII Akira, ISHIKAWA Tetsuya.

Anal Chim Acta   Vol. 983   page： 160-165   2017.8

Fatal intoxication by 5F-ADB and diphenidine: Detection, quantification, and investigation of their main metabolic pathways in humans by LC/MS/MS and LC/Q-TOFMS Reviewed

KUSANO Maiko, ZAITSU Kei, TAKI Kentaro, HISATSUNE Kazuaki, NAKAJIMA Jun'ichi, MORIYASU Takako, ASANO Tomomi, HAYASHI Yumi, TSUCHIHASHI Hitoshi, ISHII Akira.

Drug Test Anal     page： 1-10   2017.5

Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells on Concanavalin A-Induced Acute Liver Injury in Mice.

Yoshizumi Y, Yukawa H, Iwaki R, Fujinaka S, Kanou A, Kanou Y, Yamada T, Nakagawa S, Ohara T, Nakagiri K, Ogihara Y, Tsutsui Y, Hayashi Y, Ishigami M, Baba Y, Ishikawa T

Cell medicine   Vol. 9 ( 1-2 ) page： 21-33   2017.1

Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells on Concanavalin A-Induced Acute Liver Injury in Mice. Reviewed

YOSHIZUMI Yasuma, YUKAWA Hiroshi, IWAKI Ryoji, FUJINAKA Sanae, KANOU Ayano, KANOU Yuki, YAMADA Tatsuya, NAKAGAWA Shingo, OHARA Tomomi, NAKAGIRI Kenta, OGIHARA Yusuke, TSUTSUI Yoko, HAYASHI Yumi, ISHIGAMI Masatoshi, BABA Yoshinobu, ISHIKAWA Tetsuya

Cell Medicine   Vol. 9 ( 1-2 ) page： 21-33   2016.10

Importance of detoxifying enzymes in differentiating fibrotic development between SHRSP5/Dmcr and SHRSP rats. Reviewed

NAITO Hisao, JIA Xiaofang, YETTI Husna, YANAGIBA Yukie, TAMADA Hazuki, KITAMORI Kazuya, HAYASHI Yumi, WANG Dong, KATO Masashi, ISHII Akira, NAKAJIMA Tamie.

Environmental Health and Preventive Medicine     page： in press   2016.9

Development of a mass spectrometric hydroxyl-position determination method for the hydroxyindole metabolites of JWH-018 by GC-MS/MS. Reviewed

KUSANO Maiko, ZAITSU Kei, YAMANAKA Mayumi, HISATSUNE Kazuaki, ASANO Tomomi, TAKI Kentaro, HAYASHI Yumi, TSUCHIHASHI Hitoshi, ISHII Akira.

Journal of mass spectrometry   Vol. 51 ( 5 ) page： 350-357   2016.5

Intact Endogenous Metabolite Analysis of Mice Liver by Probe Electrospray Ionization/Triple Quadrupole Tandem Mass Spectrometry and Its Preliminary Application to in Vivo Real-Time Analysis Reviewed

ZAITSU Kei, HAYASHI Yumi, MURATA Tasuku, OHARA Tomomi, NAKAGIRI Kenta, KUSANO Maiko, NAKAJIMA Hiroki, NAKAJIMA Tamie, ISHIKAWA Tetsuya, TSUCHIHASHI Hitoshi, ISHII Akira

Analytical Chemistry   Vol. 88 ( 7 ) page： 3556-3561   2016.4

Malondialdehyde induces autophagy dysfunction and VEGF secretion in the retinal pigment epithelium in age-related macular degeneration Reviewed

Fuxiang Ye, Hiroki Kaneko, Yumi Hayashi, Kei Takayama; Shiang-Jyi Hwang; Yuji Nishizawa, Reona Kimoto, Yosuke Nagasaka, Taichi Tsunekawa, Toshiyuki Matsuura, Tsutomu Yasukawa, Takaaki Kondo, Hiroko Terasaki

Free Radical Biology & Medicine     page： im press   2016

Nanoparticle-rich diesel exhaust-induced liver damage via inhibited transactivation of peroxisome proliferator-activated receptor alpha. Reviewed

ITO Yuki, YANAGIBA Yukie, RAMDHAN Doni Hikmat, HAYASHI Yumi, LI Yufei, SUZUKI Akira K, KAMIJIMA Michihiro, NAKAJIMA Tamie

Environ Toxicol     2015.9

High-resolution mass spectrometric determination of the synthetic cannabinoids MAM-2201, AM-2201, AM-2232, and their metabolites in postmortem plasma and urine by LC/Q-TOFMS. Reviewed

ZAITSU Kei, NAKAYAMA Hiroshi, YAMANAKA Mayumi, HISATSUNE Kazuaki, TAKI Kentaro, ASANO Tomomi, KAMATA Tooru, KATAGAI Munehiro, HAYASHI Yumi, KUSANO Maiko, TSUCHIHASHI Hitoshi, ISHII Akira.

Int J Legal Med   Vol. 129 ( 6 ) page： 1233-1245   2015.9

Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions: a cross-sectional study. Reviewed

JIA Xiaofang, TAGAWA Masahiro, YATSUYA Hiroshi, NAITO Hisao, HAYASHI Yumi, YETTI Husna, SASAKI Seiko, ARAKI Atsuko, MIYASHITA Chihiro, IKENO Tamiko, KISHI Reiko, NAKAJIMA Tamie.

J Perinat Med.   Vol. 43 ( 5 ) page： 565-575   2015

Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study.

JIA Xiaofang, HARADA Yukiko, TAGAWA Masahiro, NAITO Hisao, HAYASHI Yumi, YETTI Husna, KATO Masashi, SASAKI Seiko, ARAKI Atsuko, MIYASHITA Chihiro, IKENO Tamiko, KISHI Reiko, NAKAJIMA Tamie.

Environ Health Prev Med.   Vol. 3   page： 168-178   2015

Metabolome disruption of the rat cerebrum induced by the acute toxic effects of the synthetic cannabinoid MAM-2201. Reviewed

ZAITSU Kei, HAYASHI Yumi SUZUKI Kei, NAKAYAMA Hiroshi, HATTORI Nanpei, TAKAHARA Rina, KUSANO Maiko, TSUCHIHASHI Hitoshi, ISHII Akira.

Life Sci.   Vol. 137   page： 49-55   2015

Prenatal Exposure to Di(2-ethylhexyl) phthalate and Subsequent Infant and Child Health Effects. Reviewed

NAKAJIMA Tamie, HAYASHI Yumi, ITO Yuki

Food Safety   Vol. 3 ( 3 ) page： 70-83   2015

Peroxisome proliferator-activated receptor α mediates di-(2-ethylhexyl) phthalate transgenerational repression of ovarian Esr1 expression in female mice Reviewed

Michihiro Kawano, Xian-Yang Qin, Midori Yoshida, Tomokazu Fukuda, Hiroko Nansai, Yumi Hayashi, Tamie Nakajima, Hideko Sone

Toxicology Letters   Vol. 228 ( 3 ) page： 235-240   2014.5

Novel positively charged nanoparticle labeling for in vivo imaging of adipose tissue-derived stem cells.

YUKAWA Hiroshi, NAKAGAWA Shingo, YOSHIZUMI Yasuma, WATANABE Masaki, SAITO Hiroaki, MIYAMOTO Yoshitaka, NOGUCHI Hirofumi, OISHI Koichi, ONO Kenji, SAWADA Makoto, KATO Ichiro, ONOSHIMA Daisuke, OBAYASHI Momoko, HAYASHI Yumi, KAJI Noritada, ISHIKAWA Tetsuya, HAYASHI Shuji, BABA Yoshinobu.

PLoS One.   Vol. 9 ( 11 ) page： e110142   2014

10. Effects of exposure to Di(2-ethylhexyl)phthalate during fetal period on next generation. Reviewed

HAYASHI Yumi, ITO Yuki, NAKAJIMA Tamie.

  Vol. 69 ( 2 ) page： 86-91   2014

A revised method for determination of dialkylphosphate levels in human urine by solid-phase extraction and liquid chromatography with tandem mass spectrometry: application to human urine samples from Japanese children.

UEYAMA Jun, SAITO Isao, TAKAISHI Ayuko, NOMURA Hiroshi, INOUE Mai, OSAKA Aya, SUGIURA Yuka, HAYASHI Yumi, WAKUSAWA Shinya, OGI Hiroko, INUZUKA Kimio, KAMIJIMA Michihiro, KONDO Takaaki.

Environ Health Prev Med.   Vol. 19 ( 6 ) page： 405-413   2014

Species and inter-individual differences in metabolic capacity of di(2-ethylhexyl)phthalate (DEHP) between human and mouse livers. Reviewed

Ito Y, Kamijima M, Hasegawa C, Tagawa M, Kawai T, Miyake M, Hayashi Y, Naito H, Nakajima T.

Environmental Health and Preventive Medicine     2013.9

High-fat-cholesterol diet-induced mainly necrosis in fibrotic steatohepatitis rats by suppressing caspase activity. Reviewed

Yetti H, Naito H, Jia X, Shindo M, Taki H, Tamada H, Kitamori K, Hayashi Y, Ikeda K, Yamori Y, Nakajima T

Life Sciences   Vol. 93 ( 18-19 ) page： 673-680   2013.9

Dysregulated bile acid synthesis, metabolism and excretion in a high fat-cholesterol diet-induced fibrotic steatohepatitis in rats. Reviewed

Jia X, Naito H, Yetti H, Tamada H, Kitamori K, Hayashi Y, Wang D, Yanagiba Y, Wang J, Ikeda K, Yamori Y, Nakajima T

Digestive Diseases and Sciences   Vol. 58 ( 8 ) page： 2212-2222   2013.7

Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. Reviewed

Nakashima R, Hayashi Y, Md K, Jia X, Wang D, Naito H, Ito Y, Kamijima M, Gonzalez FJ, Nakajima T

Toxicology     2013.4

Effect of nanoparticle-rich diesel exhaust on testicular and hippocampus steroidogenesis in male rats.

Yamagishi N, Ito Y, Ramdhan DH, Yanagiba Y, Hayashi Y, Wang D, Li CM, Taneda S, Suzuki AK, Taya K, Watanabe G, Kamijima M, Nakajima T.

Inhal Toxicol   Vol. 24 ( 8 ) page： 459-467   2012.6

Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.

Hayashi Y, Ito Y, Yanagiba Y, Kamijima M, Naito H, Nakajima T.

Arch Toxicol   Vol. 86 ( 4 ) page： 563-569   2012.4

The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model.

Jia X, Naito H, Yetti H, Tamada H, Kitamori K, Hayashi Y, Yamagishi N, Wang D, Yanagiba Y, Ito Y, Wang J, Tanaka N, Ikeda K, Yamori Y, Nakajima T.

Life Sci   Vol. 90 ( 23-24 ) page： 934-943   2012.1

Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice

Nakagawa T, Ramdhan DH, Tanaka N, Naito H, Tamada H, Ito Y, Li Y, Hayashi Y, Yamagishi N, Yanagiba Y, Aoyama T, Gonzalez FJ, Nakajima T.

Arch Toxicol   Vol. 86 ( 1 ) page： 63-74   2012.1

胎生期フタル酸ジ-2-エチルヘキシル曝露による低栄養環境と生活習慣病

林 由美, 伊藤 由起, 那須 民江

日本衛生学雑誌   Vol. 67 ( 1 ) page： 22-25   2012

Ammonium perfluorooctanoate may cause testosterone reduction by adversely affecting testis in relation to PPARα.

Nakagawa T, Ramdhan DH, Tanaka N, Naito H, Tamada H, Ito Y, Li Y, Hayashi Y, Yamagishi N, Yanagiba Y, Aoyama T, Gonzalez FJ, Nakajima T.

Toxicol Lett   Vol. 205 ( 3 ) page： 265-272   2011.9

Hepatic peroxisome proliferator-activated receptor α may have an important role in the toxic effects of di(2-ethylhexyl)phthalate on offspring of mice

Hayashi Y, Ito Y, Yamagishi N, Yanagiba Y, Tamada H, Wang D, Ramdhan DH, Naito H, Harada Y, Kamijima M, Gonzales FJ, Nakajima T.

Toxicology   Vol. 289 ( 1 ) page： 1-10   2011.2

Differential response to trichloroethylene-induced hepatosteatosis in wild-type and PPARalpha-humanized mice

Ramdhan DH, Kamijima M, Wang D, Ito Y, Naito H, Yanagiba Y, Hayashi Y, Tanaka N, Aoyama T, Gonzalez FJ, Nakajima T.

Environ Health   Vol. 118 ( 11 ) page： 1557-1563   2010.8

Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor alpha, but not human PPARalpha

Nakamura T, Ito Y, Yanagiba Y, Ramdhan DH, Kono Y, Naito H, Hayashi Y, Li Y, Aoyama T, Gonzalez FJ, Nakajima T.

Toxicology   Vol. 265 ( 1-2 ) page： 27-33   2009.9

Nanoparticle-rich diesel exhaust may disrupt testosterone biosynthesis and metabolism via growth hormone Reviewed

Ramdhan DH, Ito Y, Yanagiba Y, Yamagishi N, Hayashi Y, Li C, Taneda S, Suzuki AK, Watanabe G, Taya K, Kamijima M, Nakajima T

Toxicol Lett   Vol. 191 ( 2-3 ) page： 103-108   2009.8

PESI/MS/MSを用いたインタクト・メタボローム分析法の構築

1. 林由美、 財津桂、 村田匡、大原倫美、近藤健太、石川哲也、土橋均、石井晃、緒方是嗣、谷畑博司

第11回メタボローム・シンポジウム 

Rapid-fire direct metabolome analysis by probe electrospray ionization/tandem mass spectrometry: its preclinical applications to validate the methods. International conference

Yumi Hayashi, Kei Zaitsu, Tasuku Murata, Tomomi Ohara, Kenta Kondo, Maiko Kusano, Koretsugu Ogata, Hitoshi Tsuchihashi, Hiroshi Tanihata, Akira Ishii, Tetsuya Ishikawa

The 4th Annual European Congress of the Association for Mass Spectrometry: Application to the Clinical Lab(MSACL 2017 EU) 

Development of an in vivo real-time monitoring system using probe electrospray ionization/tandem mass spectrometry (PESI/MS/MS) and its preliminary applications International conference

Kei Zaitsu, Yumi Hayashi, Tasuku Murata, Tomomi Ohara, Stéphane Moreau, Maiko Kusano, Hiroki Nakajima, Hiroshi Tanihata, Hioshi Tsuchihashi, Tetsuya Ishikawa, Akira Ishii

65th Conference of American Society for Mass Spectrometry 

High-throughput Intact Metabolome Analysis of Mouse Biological Specimens by Probe Electrospray Ionization/Tandem Mass Spectrometry (PESI/MS/MS) International conference

Yumi Hayashi, Kei Zaitsu, Tasuku Murata, Shiono Baba, Tomomi Ohara, Stéphane Moreau, Maiko Kusano, Hiroki Nakajima, Hiroshi Tanihata, Hitoshi Tsuchihashi, Akira Ishii, Tetsuya Ishikawa

65th Conference of American Society for Mass Spectrometry 

メタボロミクスによる妊娠期DEHP曝露における胎児低生存率の解析

3. 林由美、財津桂、名仁澤英里、平野文香、大原倫美、野田 沙樹、石井晃、伊藤由起、那須民江、石川哲也

第87回日本衛生学会 

Direct drug analysis in serum by probe electrospray ionization/tandem mass spectrometry and its preliminary application to a real-time metabolism study International conference

The 9th Annual European Congress of the Association for Mass Spectrometry: Application to the Clinical Lab(MSACL 2017 US) 

nano-flow injectionESI/Q-TOFMSによる迅速メタボローム分析法の検討

瀧健太朗、財津桂、林由美、浅野友美、草野麻衣子、土橋均、石井晃

第41回日本医用マススペクトル学会 

Application of intact metabolome analysis by probe electrospray ionization (PESI)/MS/MS to local distribution analysis and in vivo real-time monitoring International conference

HAYASHI Yumi, ZAITSU Kei, MURATA Tasuku, NAKAJIMA Hiroki, KUSANO Maiko, TSUCHIHASHI Hitoshi, ISHII Akira, ISHIKAWA Tetsuya.

The 3rd Annual European Congress of the Association for Mass Spectrometry: Application to the Clinical Lab(MSACL 2016 EU) 

Real-time monitoring of glutamic acid in mouse brain by direct coupling of microdialysis to tandem mass spectrometry with the newly developed on-line desalting system International conference

ZAITSU Kei, HAYASHI Yumi, KANAYAMA Hiroaki, TAKAGI Ryosuke, NODA Saki, KUSANO Maiko, MINOHATA Toshikazu, AZUMA Jun-ichi, KANAYAMA Nobuhiro, ISHIKAWA Tetsuya, TSUCHIHASHI Hitoshi, ISHII Akira.

The 3rd Annual European Congress of the Association for Mass Spectrometry: Application to the Clinical Lab(MSACL 2016 EU) 

Intact metabolome analysis of mice biological tissues by probe electrospray ionization-tandem mass spectrometry (PESI-MS/MS) and its application to real-time analysis International conference

HAYASHI Yumi, ZAITSU Kei, MURATA Tasuku, NAKAJIMA Hiroki, KUSANO Maiko, TSUCHIHASHI Hitoshi, ISHII Akira, ISHIKAWA Tetsuya.

Royal Society of Chemistry Tokyo International Conference 2016  

脂質メディエーターとメタボローム解析よるPPARαノックアウトマウスを用いたコカイン誘発性肝障害の解析

4. 篠田諭、林由美、財津桂、酒井佑一郎、山中麻由美、那須民江、石川哲也、吉本高士、草野麻衣子、石井晃

第43回 日本毒性学会 

Development of a Hydroxyl-Position Determining Method for theMetabolites of Naphthoylindole-type Synthetic Cannabinoids by GC/MS/MS. International conference

KUSANO Maiko, ZAITSU Kei, YAMANAKA Mayumi, HISATSUNE Kazuaki, ASANO Tomomi, TAKI Kentaro, HAYASHI Yumi, TSUCHIHASHI Hitoshi, ISHII Akira.

Society pf Forensic Toxicologists(SOFT) 2015 ANNUAL MEETING 

探針エレクトロスプレー/タンデム質量分析(PESI/MS/MS)によるマウス肝臓内のメタボローム直接分析法（インタクト・メタボローム分析法）の構築

林 由美、財津 桂、 村田 匡、大原倫美、中切健太、草野麻衣子、那須民江、中島宏樹、石川哲也、土橋 均、石井 晃

第40回日本医用マススペクトル学会 

セロトニン症候群モデルラットの脳および血漿メタボローム解析

財津 桂、林 由美、木村 友哉、纐纈 雄太、小崎 朋子、山中 麻友美、草野 麻衣子、土橋 均、石井 晃

第42回日本毒性学会 

Intact Metabolome Analysis of Mice Liver by Probe Electrospray Ionization-Tandem Mass Spectrometry (PESI-MS/MS) International conference

HAYASHI Yumi, ZAITSU Kei, MURATA Tasuku, NAKAJIMA Hiroki, NAKAJIMA Tamie, TSUCHIHASHI Hitoshi, ISHII Akira, ISHIKAWA Tetsuya.

63rd American Society for Mass Spectrometry 

胎生期DEHP曝露がグルコースとレプチンに与える影響

林由美、伊藤由起、那須民江

第85回日本衛生学会 

フタル酸ジ-2-エチルヘキシル（DEHP)による精巣発達毒性にPPARαは関与しない

伊藤　由起、　林　由美、　岡本　あずさ、　上島　通浩、　那須　民江

第85回日本衛生学会 

血圧が高脂肪食摂取による肝線維化進展に影響を与えるかもしれない

内藤　久雄、賈　小芳、Yetti Husna、北森　一哉、林　由美、　加藤　昌志、　那須　民江

第85回日本衛生学会 

合成カンナビノイドMAM2201を投与したラットの血漿メタボローム解析

服部南平、財津 桂、林 由美、中山 浩、鈴木 圭、高原里奈、草野麻衣子、土橋 均、石井 晃

第39回日本医用マススペクトル学会年会 

合成カンナビノイドMAM2201投与ラットの大脳メタボローム解析

鈴木 圭、財津 桂、林 由美、中山 浩、服部南平、高原里奈、草野麻衣子、土橋 均、石井 晃

第39回日本医用マススペクトル学会年会 

フタル酸ジ-2-エチルヘキシル曝露による胎生期・発達期毒性

林　由美、伊藤　由起、那須　民江

第41回日本毒性学会年会 

合成カンナビノイドMAM2201のラット尿中代謝物の分析

久恒一晃、 財津 桂、中山 浩、林 由美、松本　智寛、石場 　厚、肥田　宗政、土橋 均、石井 晃

日本法中毒学会第33年会 

Exposure to DEHP in the pregnant mice may suppress the amount of food intakes of offspring in the development stage International conference

Yumi Hayashi, Yuki Ito, Hisao Naito, Takaaki Kondo, Michihiro Kamijima, Tamie Nakajima

The XIII International Congress of Toxicology (ICT 2013) 

胎生期フタル酸ジ-2-エチルヘキシル曝露による低栄養と生活習慣病および脳への影響

林由美、伊藤由起、近藤高明、上島通浩、那須民江

日本DOHaD研究会 

胎生期フタル酸ジ-2-エチルヘキシル曝露がレプチンに及ぼす影響

林由美、伊藤由起、内藤久雄、近藤高明、上島通浩、那須民江

環境ホルモン学会 

妊娠期DEHP曝露による母獣の血漿中トリグリセライド減少メカニズム

林由美、山岸希、伊藤由起、内藤久雄、那須民江

日本衛生学会 

妊娠マウスのDEHP曝露はPPARαを介して胎仔・新生仔の生存に影響を与える

林由美、伊藤由起、王棟、柳場由絵、山岸希、玉田葉月、ラムダンドニヒクマット、内藤久雄、那須民江

産業衛生学会 

Di (2-ethyhexy) phthalate may cause reproductive and developmental toxicity through PPARα International conference

Hayashi Y,Ito Y,Nakajima T.

International Congress of Toxicology 

胎生期DEHP曝露による低栄養と生活習慣病リスクとの関連

林由美、伊藤由起、柳場由絵、王棟、山岸希、賈小芳、内藤久雄、那須民江

日本衛生学会 

核内受容体PPARαによるフタル酸ジ-2-エチルヘキシルの生殖・次世代影響の制御

林由美、伊藤由起、玉田葉月、山岸希、柳場由絵、王棟、上島通浩、那須民江

日本衛生学会 

ディーゼル排気ナノ粒子曝露の肝臓への影響とそのメカニズム

林由美、伊藤由起、ラムダンドニヒクマット、堀心一、李宇飛、柳場由絵、李春梅、種田晋二、鈴木明、上島通浩、那須民江

日本衛生学会 

Elucidation of acute toxicity of drugs by real-time metabolome analysis and multivariate time-series analysis

Grant number：18K10122  2018.4 - 2021.3

Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

Zaitsu Kei

Investigation of pathogenesis of infant hypothermia-the association between undernutrition during gestation and thermogenesis-

Grant number：16K19271  2016.4 - 2018.3

HAYASHI Yumi

Application of novel mass spectrometric techniques for highly sensitive, specific and speedy identification of new psychoactive substances in human specimens

Grant number：15H02530  2015.4 - 2018.3

Ishii Akira

胎生期DEHP曝露による慢性炎症を基盤とした生活習慣病進展メカニズム

2014.4 - 2016.3

科学研究費補助金  若手研究(B)

胎生期DEHP曝露による仔の栄養状態と海馬・視床下部に及ぼす影響

2012.10 - 2014.3

科学研究費補助金 

DEHP胎生期曝露に招来される低栄養を特徴づける遺伝子変化と生活習慣病リスク

2010.4 - 2012.3

科学研究費補助金