Updated on 2024/03/22
医学博士 （ 1991.3 名古屋大学 ）
Legal Medicine, Analytical Chemistry, Forensic Toxicology, Mass Spectrometry, Gas Chromatography, High-Performance Liquid Chromatography, Solid Extraction Metabolomics
Others / Others / Forensic Medicine
Others / Others / Forensic Toxicology
Others / Others / Analytical Chemistry
ナノスケールLC/タンデム質量分析の法医学への応用
Application of laser spray ionization to forensic toxicology
Detection, Determination and Identification of Abused Drug by Surface Ionization Organic Mass Spectrometry.
Detection and Determination of Abused Drugs by Gas Chromatography with Surface Ionization Detection
Biochemistry of catecholamine-synthesizing enzymes
Professor and Chariman, Department of Legal Medicine, Fujita Health University School of Medicine Professor
2001.12 - 2007.4
Country：Japan
Associate Professor, Department of Legal Medicine and Bioethics, Nagoya Uninversity Graduate School of Medicine Associate Professor
1998.8 - 2001.11
Country：Japan
Research Associate, Department of Legal Medicine, Hamamatsu University School of Medicine Assistant
1993.6 - 1998.7
Country：Japan
University of California, San Francisco, Department of Neurology, Postdoctoral fellow Postdoctral fellow
1991.4 - 1993.5
Country：United States
Nagoya University Graduate School, Division of Medicine
1987.4 - 1991.3
Country： Japan
Kyoto University Faculty of Medicine
1981.4 - 1986.3
Country： Japan
日本法医学会 評議員, 理事, 監事 2001-,2009-2013, 2015~2019, 2021-
日本法中毒学会 評議員, 理事, 理事長 2000-,2006-, 2016-2022
日本医用マススペクトル学会 評議員, 理事 1999-, 2003-2007, 2009-2013 2017-
日本質量分析学会 学会委員, 編集委員 2005-2008,2006-2008
国際法中毒学会(The International Association of Foreusic Toxicologists)
2004.5 - 2004.6
Society of Forensic Toxicology
日本生命倫理学会
日本中毒学会
Chief Editor
2014.1 - 2016.2
Forensic Toxicology Associate Editor
2011.6 - 2013.12
日本法医学会教育研究委員会 委員
2009.6 - 2021.6
日本医用マススペクトル学会年会長 第37回日本医用マススペクトル学会年会会長
2011.10 - 2012.10
Japanese Association of Forensic Toxicology President
2016.3 - 2022.7
日本法中毒学会学術奨励賞
2000.6 日本法中毒学会
国際法中毒学会 Young Scientist Awards (Best Paper Section)
1999.9 国際法中毒学会
Doshi, M; Natori, Y; Ishii, A; Saigusa, D; Watanabe, S; Hosoyamada, M; Hirashima-Akae, Y
SCIENTIFIC REPORTS Vol. 14 ( 1 ) page： 3187 2024.2
Identification and quantification of diphenhydramine, haloperidol, and its metabolite, reduced haloperidol in a saponified brain specimen that was immersed in the sea water for more than 10 years
Natori Yujin, Yoshimoto Takashi, Yamamoto Toshimichi, Ishii Akira
LEGAL MEDICINE Vol. 61 page： 102188 2023.3
Medical records as screening tools for child death review in Japan
Numaguchi, A; Ishii, A; Natsume, J; Saitoh, S; Aoki, Y; Yoshikawa, T; Isobe, I; Okumura, A; Seno, H; Takahashi, Y
PEDIATRICS INTERNATIONAL Vol. 65 ( 1 ) page： e15692 2023.1
A simple and rapid method for quantifying aconitines and their metabolites in whole blood by modified QuEChERS and liquid chromatography/tandem mass spectrometry (LC/MS/MS)
Natori Yujin, Kamioka Shoki, Yoshimoto Takashi, Ishii Akira
FORENSIC SCIENCE INTERNATIONAL Vol. 341 page： 111475 2022.12
The equilibrated blood sevoflurane concentrations show a rapid decrease after switching from ventilation for the human lung to cardiopulmonary bypass
Tamura Takahiro, Mori Atsushi, Ishii Akira, Nishiwaki Kimitoshi
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 84 ( 1 ) page： 163 - 168 2022.2
A simple method for the determination of glyphosate, glufosinate and their metabolites in biological specimen by liquid chromatography/tandem mass spectrometry: an application for forensic toxicology
Ohara Tomomi, Yoshimoto Takashi, Natori Yujin, Ishii Akira
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 83 ( 3 ) page： 567 - 587 2021.8
One-Pot Extraction and Quantification Method for Bile Acids in the Rat Liver by Capillary Liquid Chromatography Tandem Mass Spectrometry
Asano Tomomi, Taki Kentaro, Kitamori Kazuya, Naito Hisao, Nakajima Tamie, Tsuchihashi Hitoshi, Ishii Akira, Zaitsu Kei
ACS OMEGA Vol. 6 ( 12 ) page： 8588 - 8597 2021.3
Desflurane and sevoflurane concentrations in blood passing through the oxygenator during cardiopulmonary bypass: a randomized prospective pilot study
Tamura Takahiro, Mori Atsushi, Ishii Akira, Ando Masahiko, Kubo Yoko, Nishiwaki Kimitoshi
JOURNAL OF ANESTHESIA Vol. 34 ( 6 ) page： 904 - 911 2020.12
RECiQ: A Rapid and Easy Method for Determining Cyanide Intoxication by Cyanide and 2-Aminothiazoline-4-carboxylic Acid Quantification in the Human Blood Using Probe Electrospray Ionization Tandem Mass Spectrometry
Hisatsune Kazuaki, Murata Tasuku, Ogata Koretsugu, Hida Minemasa, Ishii Akira, Tsuchihashi Hitoshi, Hayashi Yumi, Zaitsu Kei
ACS OMEGA Vol. 5 ( 36 ) page： 23351 - 23357 2020.9
労働現場で発生したトルエン中毒による死亡の二事例 Invited
産業医学ジャーナル Vol. 43 ( 5 ) page： 32 - 35 2020.9
A preliminary study of rapid-fire high-throughput metabolite analysis using nano-flow injection/Q-TOFMS
Taki Kentaro, Noda Saki, Hayashi Yumi, Tsuchihashi Hitoshi, Ishii Akira, Zaitsu Kei
ANALYTICAL AND BIOANALYTICAL CHEMISTRY Vol. 412 ( 17 ) page： 4127 - 4134 2020.7
Sensitive determination of midazolam and propofol in human plasma by GC-MS/MS
Kaki Yuki, Fujishiro Masaya, Lee Xiao-Pen, Kato Akihito, Sakamoto Yuki, Hashimoto Mari, Minohara Sawa, Hasegawa Chika, Hasegawa Iwao, Dohi Kenji, Kumazawa Takeshi, Ishii Akira, Sato Keizo, Matsuyama Takaaki
FORENSIC TOXICOLOGY Vol. 38 ( 2 ) page： 409 - 419 2020.7
PiTMaP: A New Analytical Platform for High-Throughput Direct Metabolome Analysis by Probe Electrospray Ionization/Tandem Mass Spectrometry Using an R Software-Based Data Pipeline
Zaitsu Kei, Eguchi Seiichiro, Ohara Tomomi, Kondo Kenta, Ishii Akira, Tsuchihashi Hitoshi, Kawamata Takakazu, Iguchi Akira
ANALYTICAL CHEMISTRY Vol. 92 ( 12 ) page： 8514 - 8522 2020.6
Development and application of a forensic toxicological library for identification of 56 natural toxic substances by liquid chromatography-quadrupole time-of-flight mass spectrometry
Ogawa Tadashi, Zaitsu Kei, Kokaji Tetsuo, Suga Kayako, Kondo Fumio, Iwai Masae, Suzuki Takayoshi, Ishii Akira, Seno Hiroshi
FORENSIC TOXICOLOGY Vol. 38 ( 1 ) page： 232 - 242 2020.1
Optimal inter-batch normalization method for GC/MS/MS-based targeted metabolomics with special attention to centrifugal concentration
Zaitsu Kei, Noda Saki, Ohara Tomomi, Murata Tasuku, Funatsu Shinji, Ogata Koretsugu, Ishii Akira, Iguchi Akira
ANALYTICAL AND BIOANALYTICAL CHEMISTRY Vol. 411 ( 26 ) page： 6983 - 6994 2019.10
Development of "Quick-DB forensic": A total workflow from QuEChERS-dSPE method to GC-MS/MS quantification of forensically relevant drugs and pesticides in whole blood
Kusano Maiko, Sakamoto Yuki, Natori Yujin, Miyagawa Haruhiko, Tsuchihashi Hitoshi, Ishii Akira, Zaitsu Kei
FORENSIC SCIENCE INTERNATIONAL Vol. 300 page： 125 - 135 2019.7
Intact metabolite profiling of mouse brain by probe electrospray ionization/triple quadrupole tandem mass spectrometry (PESI/MS/MS) and its potential use for local distribution analysis of the brain (vol 983, pg 160, 2017)
Hayashi Yumi, Zaitsu Kei, Murata Tasuku, Ohara Tomomi, Moreau Stephane, Kusano Maiko, Tanihata Hiroshi, Tsuchihashi Hitoshi, Ishii Akira, Ishikawa Tetsuya
ANALYTICA CHIMICA ACTA Vol. 1031 page： 196 - 196 2018.11
Metabolome analysis of the serotonin syndrome rat model: Abnormal muscular contraction is related to metabolic alterations and hyper-thermogenesis
Zaitsu Kei, Noda Saki, Iguchi Akira, Hayashi Yumi, Ohara Tomomi, Kimura Yuya, Koketsu Yuta, Kosaki Tomoko, Kusano Maiko, Sato Takako, Ishikawa Tetsuya, Tsuchihashi Hitoshi, Suzuki Koichi, Ishii Akira
LIFE SCIENCES Vol. 207 page： 550 - 561 2018.8
Pericardial fluid is suitable as an alternative specimen for the measurement of beta-hydroxybutyrate within 96 h after death
Mizutani Tatsushi, Yoshimoto Takashi, Ishii Akira
LEGAL MEDICINE Vol. 33 page： 53 - 54 2018.7
STR Genotyping from a Dry-Cleaned Skirt in a Sexual Assault Case
Ogawa Hisae, Hiroshige Yuuji, Yoshimoto Takashi, Ishii Akira, Yamamoto Toshimichi
JOURNAL OF FORENSIC SCIENCES Vol. 63 ( 4 ) page： 1291 - 1297 2018.7
In Vivo Real-Time Monitoring System Using Probe Electrospray Ionization/Tandem Mass Spectrometry for Metabolites in Mouse Brain
Zaitsu Kei, Hayashi Yumi, Murata Tasuku, Yokota Kazumi, Ohara Tomomi, Kusano Maiko, Tsuchihashi Hitoshi, Ishikawa Tetsuya, Ishii Akira, Ogata Koretsugu, Tanihata Hiroshi
ANALYTICAL CHEMISTRY Vol. 90 ( 7 ) page： 4695 - 4701 2018.4
High-throughput determination of valproate in human samples by modified QuEChERS extraction and GC-MS/MS
Mizuno Shun, Lee Xiao-Pen, Fujishiro Masaya, Matsuyama Takaaki, Yamada Miho, Sakamoto Yuki, Kusano Maiko, Zaitsu Kei, Hasegawa Chika, Hasegawa Iwao, Kumazawa Takeshi, Ishii Akira, Sato Keizo
LEGAL MEDICINE Vol. 31 page： 66 - 73 2018.3
Fatal intoxication by 5F-ADB and diphenidine: Detection, quantification, and investigation of their main metabolic pathways in humans by LC/MS/MS and LC/Q-TOFMS
Kusano Maiko, Zaitsu Kei, Taki Kentaro, Hisatsune Kazuaki, Nakajima Jun'ichi, Moriyasu Takako, Asano Tomomi, Hayashi Yumi, Tsuchihashi Hitoshi, Ishii Akira
DRUG TESTING AND ANALYSIS Vol. 10 ( 2 ) page： 284 - 293 2018.2
Highly sensitive determination of alendronate in human plasma and dialysate using metal-free HPLC-MS/MS
Yamada Miho, Lee Xiao-Pen, Fujishiro Masaya, Iseri Ken, Watanabe Makoto, Sakamaki Hiroshi, Uchida Naoki, Matsuyama Takaaki, Kumazawa Takeshi, Takahashi Haruo, Ishii Akira, Sato Keizo
LEGAL MEDICINE Vol. 30 page： 14 - 20 2018.1
Intact metabolite profiling of mouse brain by probe electrospray ionization/triple quadrupole tandem mass spectrometry (PESI/MS/MS) and its potential use for local distribution analysis of the brain
Hayashi Yumi, Zaitsu Kei, Murata Tasuku, Ohara Tomomi, Moreau Stephane, Kusano Maiko, Tanihata Hiroshi, Tsuchihashi Hitoshi, Ishii Akira, Ishikawa Tetsuya
ANALYTICA CHIMICA ACTA Vol. 983 page： 160 - 165 2017.8
A human genotyping trial to estimate the post-feeding time from mosquito blood meals
Hiroshige Yuuji, Hara Masaaki, Nagai Atsushi, Hikitsuchi Tomoyuki, Umeda Mitsuo, Kawajiri Yumi, Nakayama Koji, Suzuki Koichi, Takada Aya, Ishii Akira, Yamamoto Toshimichi
PLOS ONE Vol. 12 ( 6 ) page： e0179319 2017.6
Simultaneous quantification of batrachotoxin and epibatidine in plasma by ultra-performance liquid chromatography/tandem mass spectrometry
Shiraishi Yosuke, Ogawa Tadashi, Suzuki Takayoshi, Iwai Masae, Kusano Maiko, Zaitsu Kei, Kondo Fumio, Ishii Akira, Seno Hiroshi
LEGAL MEDICINE Vol. 25 page： 1 - 5 2017.3
Sensitive determination of picrotoxin by liquid chromatography-quadrupole time-of-flight mass spectrometry Reviewed
Tadashi Ogawa*, Miho Tada, Hideki Hattori, Yosuke Shiraishi, Takayoshi Suzuki, Masae Iwai, Maiko Kusano, Kei Zaitsu, Akira Ishii, Hiroshi Seno
Legal Medicine Vol. 20 page： 8-11 2016.3
Metabolome disruption of the rat cerebrum induced by the acute toxic effects of the synthetic cannabinoid MAM-2201 Reviewed
Kei Zaitsu, Yumi Hayashi, Kei Suzuki, Hiroshi Nakayama, Nanpei Hattori, Rina Takahara, Maiko Kusano, Hitoshi Tsuchihashia, Akira Ishii
Life Sciences Vol. 137 ( 15 ) page： 49-55 2015.9
High-resolution mass spectrometric determination of the synthetic cannabinoids MAM-2201, AM-2201, AM-2232, and their metabolites in postmortem plasma and urine by LC/Q-TOFMS Reviewed
Kei Zaitsu, Hiroshi Nakayama, Mayumi Yamanaka, Kazuaki Hisatsune, Kentaro Taki, Tomomi Asano, Tooru Kamata, Munehiro Katagai, Yumi Hayashi, Maiko Kusano, Hitoshi Tsuchihashi, Akira Ishii
International Journal of Legal Medicine Vol. 129 ( 6 ) page： 1233-1245 2015.9
A case of sudden death after Japanese encephalitis vaccination Reviewed
Yasuo Bunai, Akira Ishii, Kayoko Akaza, Atsushi Nagai, Naoki Nishida, Seiji Yamaguchi
Legal Medicine Vol. 17 ( 4 ) page： 279-282 2015.7
Identification and quantitation of mifepristone and its N-demethyl metabolite in the plasma of an aborted fetus by liquid chromatography–quadrupole–time-of-flight–mass spectrometry (LC–Q–TOFMS) and ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS–MS) Reviewed
Akira Ishii, Kei Zaitsu, Maiko Kusano, Tomomi Asano, Tadashi Ogawa, Hideki Hattori, Hiroshi Seno
Forensic Toxicology Vol. 33 ( 2 ) page： 409-412 2015.6
A preliminary study on postmortem interval estimation of suffocated rats by GC-MS/MS-based plasma metabolic profiling Reviewed
Takako Sato, Kei Zaitsu, Kento Tsuboi, Masakatsu Nomura, Maiko Kusano, Noriaki Shima, Shuntaro Abe, Akira Ishii, Hitoshi Tsuchihashi, Koichi Suzuki
Analytical Bioanalytical Chemistry Vol. 407 ( 13 ) page： 3659-3665 2015.5
Positional isomer differentiation of synthetic cannabinoid JWH-081 by GC-MS/MS Reviewed
Maiko Kusano, Kei Zaitsu, Hiroshi Nakayama, Junichi Nakajima, Kazuaki Hisatsune, Takako Moriyasu, Shuntaro Matsuta, Munehiro Katagi, Hitoshi Tsuchihashi, Akira Ishii
Journal of Mass Spectrometry Vol. 50 ( 3 ) page： 586-591 2015.2
Identification of N,N-bis(1-pentylindol-3-yl-carboxy)naphthylamine (BiPICANA) found in an herbal blend product in the Tokyo metropolitan area and its cannabimimetic effects evaluated by in vitro [35S]GTPγS binding assays Reviewed
Jun'ichi Nakajima, Misako Takahashi, Nozomi Uemura, Takako Seto, Haruhiko Fukaya, Jin Suzuki, Masao Yoshida, Maiko Kusano, Hiroshi Nakayama, Kei Zaitsu, Akira Ishii, Takako Moriyasu, Dai Nakae
Forensic Toxicology Vol. 33 ( 1 ) page： 84-92 2015.1
Simple and sensitive determination of α- and β-amanitin by liquid chromatography–quadrupole time-of-flight mass spectrometry Reviewed
Ishii, A., Tada, M., Kusano, M., Ogawa, T., Hattori, H., Seno, H., Zaitsu, K.
Forensic Toxicology Vol. 32 ( 2 ) page： 342-346 2014.8
Metabolism of the newly encountered designer drug α-pyrrolidinovalerophenone in humans: identification and quantitation of urinary metabolites Reviewed
Noriaki Shima, Munehiro Katagi, Hiroe Kamata, Shuntaro Matsuta, Keiko Sasaki, Tohru Kamata, Hiroshi Nishioka, Akihiro Miki, Michiaki Tatsuno, Kei Zaitsu, Akira Ishii, Takako Sato, Hitoshi Tsuchihashi, Koichi Suzuki
Forensic Toxicology Vol. 32 ( 1 ) page： 59-67 2014.8
High-throughput analysis of ramelteon, agomelatine, and melatonin in human plasma by ultra-performance liquid chromatography–tandem mass spectrometry Reviewed
Tadashi Ogawa, Masae Iwai, Hideki Hattori, Kei Zaitsu, Takeshi Kumazawa, Akira Ishii, Osamu Suzuki, Hiroshi Seno
Forensic Toxicology Vol. 32 ( 1 ) page： 126-131 2014.8
A possible role of chenodeoxycholic acid and glycine-conjugated bile acids in fibrotic steatohepatitis in a dietary rat model Reviewed
Jia, X., Suzuki, Y., Naito, H., Yetti, H., Kitamori, K., Hayashi, Y., Kaneko, R., Nomura, M., yamori, Y., Zaitsu, K., Kato, M., Ishii, A., Nakajima, T.
Digestive Diseases and Sciences Vol. 59 ( 7 ) page： 1490-1501 2014.7
Metabolic profiling of urine and blood plasma in rat models of drug addiction on the basis of morphine, methamphetamine, and cocaine-induced conditioned place preference. Reviewed
Zaitsu, K., Miyawaki, I., Bando, K., Horie, H., Shima N., Katagi, M.,Tatsuno, M., Bamba, T., SatoT., Ishii, A., Tsuchihashi, H., Suzuki, K., Fukusaki.
Analytical Bioanalytical Chemistry Vol. 406 page： 1339-1354 2014.2
SIMPLE AND RAPID ASSAY METHOD FOR SIMULTANEOUS QUANTIFICATION OF URINARY NICOTINE AND COTININE USING MICRO-EXTRACTION BY PACKED SORBENT AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY Reviewed
Iwai M, Ogawa T, Hattori H, Zaitsu K, Ishii A, Suzuki O, Seno H
Nagoya Journal of medical Sciences Vol. 75 ( 3, 4 ) page： 255-261 2013.8
Mass spectrometric differentiation of the isomers of mono-methoxyethyl- amphetamines and mono-methoxydimethylamphetamines by GC–EI–MS–MS Reviewed
Kei Zaitsu, Haruhiko Miyagawa, Yuki Sakamoto, Shuntaro Matsuta, Kento Tsuboi, Hiroshi Nishioka, Munehiro Katagi, Takako Sato, Michiaki Tatsuno, Hitoshi Tsuchihashi, Koichi Suzuki, Akira Ishii
Forensic Toxicology Vol. 31 page： 292-300 2013.7
Simple and rapid quantitation of 21 bile acids in rat serum and liver by UPLC-MS-MS: Effect of high fat diet on glycine conjugates of rat bile acids Reviewed
Vol. 75 ( 1, 2 ) page： 57-71 2013.2
Simple and rapid analysis of amatoxins using UPLC-MS-MS. Reviewed
Nomura, M., Suzuki, Y., Kaneko, R., Ogawa, T., Hattori, H., Seno, H., Ishii, A.
Forensic Toxicology Vol. 30 page： 185-192 2012
A rapid and simultaneous analysis of theophylline and its metabolites in human whole blood by ultra-performance liquid chromatography-tandem mass spectrometry. Reviewed
Ogawa, T., Hattori, T., Iwai, M., Ito, K., Itakura, K., Ishii, A., Suzuki, O., Seno, H.
Forensic Toxicology Vol. 30 page： 142-148 2012
Diagnosis of fulminant type 1 diabetes mellitus in an autopsy case with postmortem changes. Reviewed
Mizutani, T., Yoshimoto, T., Kaneko, R., Ishii, A.
Legal Medicine Vol. 13 page： 250-253 2011
Central nervous system involvement in n-hexane polyneuropathy demonstrated by MRI and proton MR spectroscopy. Reviewed
Hashizume A, Koike H, Kawgashira Y, Banno H, Suzuki K, Ito M, Matsuno M, Watanabe H, Tanaka F, Nakagawa S, Kaneko R, Ishii A, Subue G.
Clinical Neurology and Neurosurgery Vol. 113 page： 493-495 2011
Simple analysis of blonanserin, a novel antipsychotic agent, in human plasma by GC-MS Reviewed
H Hattori, M Iwai, T Ogawa, Y Mizutani, A Ishii, O Suzuki, H Seno
Forensic Toxicology Vol. 28 ( 2 ) page： 105-109 2010.7
Simple analysis of alfa-amanitin and beta-amanitin in human plasma by liquid-chromatography-massspectrometry Reviewed
M Tanahashi, R Kaneko, Y Hirata, M Hamajima, T Arinobu, T Ogawa, A Ishii
Forensic Toxicology Vol. 28 ( 2 ) page： 110-114 2010.7
Sensitive analysis of blonanserin, a novel antipsychotic agent, in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry Reviewed
T Ogawa, H Hattori, R Kaneko, K Ito, M Iwai, Y Mizutani, T Arinobu, A Ishii, O Suzuki, H Seno
Analytical Sciences Vol. 26 page： 1099-1102 2010
Simultaneous analysis of aconitine, mesaconitine, hypaconitine, and jesaconitine in whole blood by LC-MS-MS using a new polymer column Reviewed
Hattori, H, Hirata, Y, Hamajima, M, Kaneko, R, Ito, K, Ishii, A, Suzuki, O, Seno, H
Forensic Toxicology Vol. 27 ( 1 ) page： 7-11 2009
High-throughput determination of theophyline and caffeine in human serum by conventional liquid chromatography-mass spectrometry Reviewed
Arinobu, T, Hattori, H, Kumazawa, T, Lee, X-P, Mizutani, Y, Katase T, kojima S, Omori, T, Kaneko, R, Ishii, A, Seno, H
Forensic Toxicology Vol. 27 ( 1 ) page： 1-6 2009
薬毒物中毒 Invited
石井 晃
現代医学 Vol. 56 page： 169-173 2008.7
Application of new mass spectrometric techniques to legal medicine Invited Reviewed
A, Ishii, R, Kaneko, Y, Hirata, M, Hamajima
J Mass Spectrom Soc Japan Vol. 56 ( 3 ) page： 131-138 2008
Rapid analysis of sertraline, fluvoxamine, and paroxetine in serum specimens by LC-MS-MS using a new polymer column Reviewed
H, Hattori, K, Ito, M, Iwai, T, Arinobu, Y, Mizutani, T, Kumazawa, A, Ishii, O, Suzuki, H, Seno
Forensic Toxicology Vol. 25 page： 100-103 2007
*Sensitive analysis of aconitine, hypaconitine, mesaconitine and jesaconitine in human body fluids and Aconitum tubers by LC/ESI-TOF-MS
Kaneko, R., Hattori, S., Furuta, S., Hamamjima, M., Hirata, Y., Watanabe, K., Seno, H. and Ishii, A.
Journal of Mass Spectrometry Vol. 41 page： 810-814 2006
Pipette tip solid-phase extraction and gas chromatography-mass spectrometry for the determination of mequitazine in human plasma Reviewed
T Kumazawa, Ch Hasegawa, X-P Lee, A Marumo, n Shimmen, A Ishii, H Seno, K Sato
Talanta Vol. 70 page： 474-478 2006
Problems in blood alcohol testing of severely injured drivers brought to emergency departments in Japan Reviewed
Higuchi, A., Kurihara, R., Yoshimoto, T., Sano, T., Katsumata, K., Ishii, A. and Katsumata, Y.
Legal Medicine Vol. 7 page： 299-305 2005
Determination of paraquat and diquat in human body fluids by high-performance liquid chromatography/tandem mass spectrometry Reviewed
Lee, X.-P., Kumazawa, T., Fujishiro, M., Hasegawa, Ch., Arinobu, T., Seno, H., Ishii, A. and Sato, K.
Journal of Mass Spectrometry Vol. 39 page： 1147-1152 2005
Determination of barbital in human body fluids by solid-phase microextraction and gas chromatography/mass spectrometry Reviewed
Masuda, K., Arinobu, T., Kumazawa, T., Iwai, M., Mizudani, Y., Hattori, H., Ishii, A., Suzuki, O. and Seno, H.
Japanese Journal of Forensic Toxicology Vol. 23 page： 37-40 2005
Sensitive determination of acetonitrile and propionitrile in human whole blood by headspace capillary gas chromatography with cryogenic oven trapping Reviewed
Kaneko, R., Fukui, R., Watanabe, K., Hirata, Y., Hamajima, M. and Ishii, A.
Japanese Journal of Forensic Toxicology Vol. 23 page： 33-36 2005
Simultaneous analysis of nitrite and nitrate in whole blood by ion chromatography Reviewed
Suzuki, O., Watanabe, K., Okamoto, N., Nozawa, H. and Ishii, A.
Journal of Liquid Chromatogry and Related Technologies Vol. 28 page： 3077-3085 2004
Simultaneous determination of barbiturates in human biological fluids by direct immersion solid-phase microextraction and gas chromatography-mass spectrometry Reviewed
Iwai, M., hattori, H., Arinobu, T., Ishii, A., Kumazawa, T., Noguchi, H., Noguchi, H., Suzuki, O. and Seno, H.
Journal of Chromatography B Vol. 806 page： 65-73 2004
Simple analysis of acetaminophen in human plasma by solid-phase microextraction and gas chromatography Reviewed
Hamajima, M., Ishida, S., Hirata, Y., Hirata, K., Watanabe, K., Seno, H. and Ishii, A.
Japanese Journal of Forensic Toxicology Vol. 22 page： 22-26 2004
Simple analysis of amphetamines in human whole blood and urine by headspace capillary gas chromatography with large volume injection Reviewed
Watanabe, K., Okamoto, N., Yamaguchi, I., Nozawa, H., Ishii, A. and Suzuki, O.
Chromatographia Vol. 58 page： 455-458 2003
Comparison of sonic spray ionization with atomospheric pressure chemical ionization as an interface of liquid chromatography-mass spectrometry for the analysis of some local anesthetics Reviewed
Arinobu, T., Hattori, H. Ishii, A., Kumazawa, T., Lee, X.-P., Suzuki, O. and Seno, H.
Chromatographia Vol. 57 page： 301-307 2003
Sensitive analysis of alkyl alcohols as de- composition products of alkyl nitrites in human whole blood and urine by headspace capillary GC with cryogenic oven trapping Reviewed
Watanabe-Suzuki, K., Nozawa, H., Suzuki, O. and Ishii, A.
Journal of Chromatographical Sciences Vol. 41 page： 63-66 2003
Rapid analysis of pentazocine in human plasma by liquid chromato- graphy/mass spectrometry with sonic spray ionization Reviewed
Arinobu, T., Hattori, H., Ishii, A., Kumazawa, T., Lee, X.-P., Kojima, S., Suzuki, O. and Seno, H.
Analytica Chimica Acta Vol. 492 page： 249-252 2003
*Sensitive determination of pethidine in body fluids by gas chromatography-tandem mass spectrometry Reviewed
Ishii, A., Tanaka, M., Kurihara, R., Watanabe-Suzuki, K., Kumazawa, T., Seno, H., Suzuki, O. and Katsumata, Y.
Journal of Chromatography B Vol. 792 page： 117-121 2003
Stability of alkyl alcohols as decomposition products of alkyl nitrites in human whole blood Reviewed
Watanabe, K., Okamoto, N., Nozawa, H., Ishii, A., Goto, H. and Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 21 page： 256-261 2003
Traumatic basal subarachnoid haemorrhage caused by the impact of a golf ball: a case report Reviewed
Watanabe-Suzuki, K., Suzuki, O., Nozawa, H. and Ishii, A.
Medicine, Science and Law Vol. 42 page： 174-178 2002
*Application of gas chromatography-surface ionization organic mass spectrometry to forensic toxicology Invited Reviewed
Ishii, A., Watanabe- Suzuki, K., Seno, H., Suzuki, O. and Katsumata, Y.
Journal of Chromatography B Vol. 776 page： 3-15 2002
Comparison of SSI with APCI as an interface of HPLC-mass spectrometry for analysis of a drug and its metabolites Reviewed
Arinobu, T., Hattori, H., Seno, H., Ishii, A. and Suzuki, O.
Journal of American Society of Mass Spcetrometry Vol. 13 page： 204-208 2002
A curious case of a car crash in which self-strangulation and lung collapse were found: A case report Reviewed
Watanabe-Suzuki, K., Suzuki, O., Kosugi, I., Seno, H. and Ishii, A.
Medicine, Science and Law Vol. 42 page： 261-264 2002
Liquid chromatographic-mass spectrometric determination of haioperidol and its metabolites in human plasma and urine Reviewed
Arinobu, T., Hattori, H., Iwai, M., Ishii, A., Kumazawa, T., Suzuki, O. and Seno, H.
Journal of Chromatography B Vol. 776 page： 103-113 2002
An autopsy case of a stunt man who jumped into seawater riding a motorcycle: a case report Reviewed
Watanabe-Suzuki, K., Suzuki, O., Nozawa, H. and Ishii, A.
Medicine, Science and Law Vol. 43 page： 355-357 2002
An autopsy case of human remains with a numerical variation in thoraco-lumbar vertebrae Reviewed
Nozawa, H., Suzuki-Watanabe, K., Seno, H., Ishii, A. and Suzuki, O.
Legal Medicine Vol. 4 page： 123-126 2002
Determination of caffeine and theophylline in human whole blood by stir bar sorptive extraction (SBSE)-thermal desorption- capillary gas chromatography-mass spectrometry Reviewed
Kumazawa, T., Lee, X.-P., Takano, M., Seno, H., Arinobu, T., Ishii, A., Suzuki, O. and Sato, K.
Japanese Journal of Forensic Toxicology Vol. 20 page： 295-302 2002
Identification and characterization of 17 phenothiazine compounds by capillary high-performance liquid chromatography/fast atom bombardment mass spectrometry Reviewed
Mizuno, Y., Sato, K., Sano, T., Kurihara, R., Kojima, T., Yamakawa, Y., Ishii, A. and Katsumata, Y.
Legal Medicine Vol. 4 page： 207-216 2002
Determination of cresol isomers and phenol in human body fluids by capillary gas chromatography with cryogenic oven trapping Reviewed
Lee, X.-P., Kumazawa, T., Saito, K., Takano, M., Hattori, H., Seno, H., Ishii, A., Watanabe-Suzuki, K., Suzuki, O. and Sato, K
Analytical Letters Vol. 35 page： 2093-2103 2002
A case of death due to rescue action by a power shovel after being buried alive Reviewed
Watanabe-Suzuki, K., Nozawa, H., Ishii, A., Seno, H. and Suzuki, O.
Legal Medicine Vol. 3 page： 241-245 2001
Sensitive determination of pethidine in body fluids by surface ionization organic mass spectrometry Reviewed
Ishii, A., Kurihara, R., Watanabe-Suzuki, K., Kumazawa, T., Seno, H., Matsushima, H., Suzuki, O. and Katsumata, Y.
Journal of Chromatography B Vol. 758 page： 117-121 2001
Dopamine D2 receptor inhibition of adenylyl cyclase is abolished by acute ethanol but restored after chronic exposure (tolerance). Reviewed
Yao, L., Asai, K., Zhan, J., Ishii, A., Fan, P., Gordon, A. S. and Diamond, I.
Journal of Pharmacology and Experomental Therapeutics Vol. 298 page： 833-839 2001
Sensitive determination of midazolam and identification of its two metabolites in human body fluids by column-switching capillary high-performance liquid chromatography/fast atom bombardment-mass spectrometry Reviewed
Sano T., Sato K., Kurihara R., Mizuno Y., Kojima T., Yamakawa Y., Yamada T., Ishii A. and Katsumata Y.
Legal Medicine Vol. 3 page： 149-156 2001
Sensitive determination of four general anaesthetics in human whole blood by capillary gas chromatography with cryogenic oven trapping Reviewed
Kojima T., Ishii A., Watanabe-Suzuki K., Kurihara R., Seno H., Kumazawa T., Suzuki O. and Katsumata Y.
Journal of Chromatography B Vol. 762 page： 103-108 2001
Sensitive determination of styrene and related compounds in human body fluids by headspace capillary gas chromatography with cryogenic oven trapping Reviewed
Watanabe-Suzuki, K., Ishii, A., Seno, H., Takeuchi, Y. and Suzuki, O.
Chromatographia Vol. 54 page： 507-510 2001
*Ultrasensitive determination of phencyclidine in body fluids by surface ionization organic mass spectrometry Reviewed
Ishii, A., Seno, H., Watanabe-Suzuki, K., Kumazawa, T., Matsushima, H., Suzuki, O. and Katsumata, Y.
Analytical Chemistry Vol. 72 ( 2 ) page： 404-407 2000
Determination of pentazocine in human whole blood and urine by gas chromatography/surface ionization organic mass spectrometry (jointly authored) Reviewed
Seno, H., Kumazawa, T., Ishii, A., Matsushima, H., Watanabe-Suzuki, K. and Suzuki, O.
Journal of Mass Spectrometry Vol. 35 page： 33-38 2000
Analysis of phenothiazines in human body fluids by solid-phase microextraction and liquid chromatography/tandem mass spectrometry Reviewed
Kumazawa, T., Seno, H., Watanabe-Suzuki, K., Hattori, H., Ishii, A., Sato, K. and Suzuki, O.
Journal of Mass Spectrometry Vol. 35 page： 1091-1099 2000
Stability of ethyl acetate in whole blood during storage under various conditions Reviewed
Watanabe-Suzuki, K., Ishii, A., Seno, H., Kumazawa, T. and Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 18 ( 8 ) page： 237-243 2000
A curious autopsy case of accidental carbon monoxide poisoning in a motor vehicle Reviewed
Kumazawa, T., Watanabe-Suzuki, K., Seno, H., Ishii, A. and Suzuki, O.
Legal Medicine Vol. 2 page： 181-185 2000
Simple extraction of gamma-hydroxybutyrate in human whole blood by headspace solid-phase microextraction Reviewed
Kurihara, R., Ishii, A., Watanabe-Suzuki, K., Kumazawa, T., Suzuki, O., Seno, H. and Katsumata, Y.
Japanese Journal of Forensic Toxicology Vol. 19 page： 38-45 2000
Determination of triazine herbicides in human body fluids by solid-phase microextraction and capillary gas chromatography (jointly authored) Reviewed
Kumazawa, T., Lee, X.-P., Kondo, K., Sato, K., Watanabe-Suzuki, K., Ishii, A. and Suzuki, O.
Chromatographia Vol. 52 ( 3/4 ) page： 195-199 2000
シアンと類似化合物の分析 Invited
石井 晃
現代医学 Vol. 47 ( 1 ) page： 15-21 1999.7
Ultra-sensitive method for determination of ethanol in whole blood by head space capillary gas chromatography with cryogenic oven trapping. (jointly authored) Reviewed
Watanabe-Suzuki, K., Seno, H., Ishii, A., Kumazawa, T., Suzuki, O.
Journal of Chromatography B Vol. 727 page： 89-94 1999
A method for simultaneons determination of five anticoagulant rodenticides in whole blood by high-performance liquid chromatography(jointly authored) Reviewed
Guan, F., Ishii, A., Seno, H., Watanabe, K., Kumazawa, T., Suzuki, O.
Journal of Pharmacentical and Biomedical Analysis Vol. 21 page： 179-185 1999
Positive-ion, negative-ion and surface ionization mass spectra of MPTP and its derivatives. Reviewed
A Ishii, H Seno, K Watanabe-Suzuki, N Castagnoli Jr, H Inoue, T Kumazawa, O Suzuki, Y Katsumata
Japanese journal of forensic toxicology. Vol. 17 ( 3 ) page： 195-202 1999
Use of ion-pair reagent for HPLC-APCI-MS determination of anionic anticoagurant rodenticides in body fluids. (jointly authored) Reviewed
Guan, F., Ishii, A., Seno, H., Watanabe-Suzuki, K., Kumazawa, T., Suzuki, O.
Journal of Chromatography B Vol. 731 page： 155-165 1999
Solid-phase microextraction(SPME) and GC-ECD of benzophenones for determination of benzodiazepines in urine. (jointly authored) Reviewed
Guan, F., Seno, H., Ishii, A., Watnabe, K., Kumazawa, T., Hattori, H., Suzuki, O.
Journal of Analytical Toxicology Vol. 23 page： 54-61 1999
Sensitive determination of ethanol in human breath by headspace capillary gas chromatography with cryogenic oven trapping. (jointly authored) Reviewed
Watanabe-Suzuki, K., Seno, H., Ishii, A., Kumazawa, T., Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 17 ( 1 ) page： 61-65 1999
High performance liquid chromatography / electrospray tandem mass spectrometry for phenothiazines with heavy side chains in whole blood (jointly authored) Reviewed
H Seno, H Hattori, A Ishii, T Kumazawa, K Watanabe-Suzuki, O Suzuki
Rapid communications in mass spectrometry Vol. 13 page： 2394-2398 1999
向精神薬の分析 Invited
石井 晃, 服部秀樹
現代医学 Vol. 47 ( 1 ) page： 7-13 1999
Identification and quantitation of cardiac glycosides in blood and urine samples by HPLC/MS/MS. (jointly authored) Reviewed
F Guan, A Ishii, H Seno, K Watanabe-Suzuki, T Kumazawa, O Suzuki
Analytical chemistry Vol. 71 ( 18 ) page： 4034-4043 1999
毒物検索システム Invited Reviewed
石井 晃, 勝又義直
現代医学 Vol. 46 ( 3 ) page： 467 1999
Positive- and negative-ion mass spectromery of non-steroidal antiinflammatory agents and their clean-up with Bond Elut Glass C_18 from biological samples (jointly authored) Reviewed
Seno, H., Hattori, H., Kumazawa, T., Ishii, A., Watanabe-Suzuki, K., Suzuki, O.
Forensic Science International Vol. 100 page： 143-147 1999
Extraction of methylxanthines from human body fluids by solid phase microextraction. (jointly authored) Reviewed
Kumazawa, T., Seno, H., Lee, X.-P., Ishii, A., Watanabe-Suzuki, O., Sato, K., Suzuki, O.
Analytical Chimica Acta Vol. 387 page： 53-60 1999
Extraction of chloroform and methylene chloride in human whole blood and urine by headspace solid phase microextraction (SPME) (jointly authored) Reviewed
H Seno, A Ishii, K Watanabe, O Suzuki, T Kumazawa
Medicine science and law Vol. 39 ( 4 ) page： 332-336 1999
Headspace solid-phase microextraction and gas chromatographic determination of dinitroaniline herbicides in human blood, urine and environmental water. (jointly authored) Reviewed
Guan, F., Watanabe, K., Ishii, A., Seno, H., Kumazawa, T., Hattori, H., Suzuki, O.
Journal of Chromatography B. Vol. 714 page： 205-213 1998
*Determination of cyanide in whole blood by capillary gas chromatography with cryogenic oven trapping. Reviewed
Ishii, A., Seno, H., Watanabe- Suzuki, K.,Suzuki, O. and Kumazawa, T.
Analytical Chemistry Vol. 70 ( 22 ) page： 4873 1998
Sensitive determination of xylenes in whole blood by capillary gas chromatography with cryogenic trapping. (jointly authored) Reviewed
Hattori, H., Iwai, M., Kurono, S., Yamada, T., Watanabe-Suzuki, K., Ishii, A., Seno, H., Suzuki, O.
Journal of Chromatography B. Vol. 718 page： 285-289 1998
Monoamine oxidase activities in cat fish(Parasilurs asotus)tissues. (joinyly authored) Reviewed
Kumazawa, T., Seno, H., Ishii, A., Suzuki, O.
Journal of Enzyme Inhibition Vol. 13 page： 377-384 1998
Improved extraction of ethanol from human body fluids by headspace solid-phase extraction with a carboxene-polydimethylsiloxane-coated fiber. (jointly authored) Reviewed
X-P Lee, T Kumazawa, K Sato, H Seno, A Ishii, O Suzuki
Chomatographia Vol. 47 page： 593-595 1998
Varying effects of ethanol on transfected cell lines. (jointly authored) Reviewed
Asai, K., Ishii, A., Diamond, I., Gordon, A. S.
Alcoholism-Clinical and Experimental Reseach Vol. 22 page： 163-166 1998
Sensitive determination of ethyl ether in whole blood by capillary gas chromatography with cryogenic trapping. (jointly authored) Reviewed
Watanabe, K., Seno, H., Ishii, A., Kumazawa, T., Hattori, H., Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 16 ( 1 ) page： 69-74 1998
Characterization of β-phenethylamine-induced monoamine release in rat nucleus accumbens : a microdialysis study. (jointly authored) Reviewed
Nakamura, M., Ishii, A., Nakahara, D.
Europian Journal of Pharmacology Vol. 349 page： 163-169 1998
A fatal case of profenofos poisoning. (jointly authored) Reviewed
Seno, H., Hattori, H., Kumazawa, T., Ishii, A., Watanabe, K., Suzuki, O.
Journal of Toxicology-Clinical Toxicology Vol. 36 page： 63-65 1998
Positive-and negative-ion mass spectrometry of alkyl derivatives of cocaine. (jointly authored) Reviewed
Kumazawa, T., Watanabe-Suzuki, K., Seno, H., Ishii, A., Sato, K., Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 16 ( 3 ) page： 221-227 1998
Capillary gas chromatography with cryogenic oven temperature for headspace samples : Analysis of chloroform of methylene chloride in whole blood. (jointly authored) Reviewed
Watanabe, K., Seno, H., Ishii, A., Suzuki, O.
Analytical Chemistry Vol. 69 page： 5178-5181 1997
A death case in which the victim was run over after intake of psychopharmaceutical drugs including carbamazepine. Reviewed
Ishii, A., Seno, H., Watanabe, K., Guan, F., Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 15 ( 3 ) page： 226-230 1997
Simple extraction of 1-phenylethylamine in human urine by headspace solid phase microextraction. Reviewed
Ishii, A., Seno, H., Guan, F., Wantanabe, K., Kumazawa, T., Hattori, H., Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 15 ( 3 ) page： 189-193 1997
Nonfatal suicidal intoxication by clozapine Reviewed
Ishii, A., Mizoguchi, K., Kageoka, M., Seno, H., Kumazawa, T., Suzuki, O.
Journal of Toxicology-Clinical Toxicology Vol. 35 ( 2 ) page： 195-197 1997
Simultaneous determination of cocaethylene and cocaine in blood by gas chromatography with surface ionization detection(jointly authored) Reviewed
Watanabe, K., Hattori, H., Nishikawa, M., Ishii, A., Kumazawa, T., Seno, H., Suzuki, O.
Chromatographia Vol. 44 ( 1-2 ) page： 55-58 1997
Simple analysis of diphenylmethane antihistaminics and their analogues in bodily fluids by headspace solid-phase microextraction-capillary gas chromatography(jointly authored) Reviewed
Nishikawa, M., Seno, H., Ishii, A., Suzuki, O, Kumazawa, T., Watanabe, K., Hattori, H.
Journal of Chromatographic Sciences Vol. 35 page： 275-279 1997
Detection of benzodiazepines in human urine by direct immersion solid phase micro extraction and gas chromatography(jointly authored) Reviewed
Seno, H., Kumazawa, T., Ishii, A., Watanabe, K., Hattori, H., Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 15 ( 1 ) page： 16-20 1997
Sensitive determination of trichloroethylene in blood and urine by capillary gas chromatography with cryogenic trapping. (jointly authored) Reviewed
Watanabe, K., Seno, H., Ishii, A., Kumazawa, T., Hattori, H., Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 15 ( 3 ) page： 211-216 1997
A simple and sensitive quantitation of N, N-dimethyltryptamine by gas chromatography with surface ionization detection Reviewed
Ishii, A., Seno, H., Suzuki, O., Hattori, H., Kumazawa, T.
Journal of Analytical Toxicology Vol. 21 ( 1 ) page： 36-40 1997
Simple and seusitive detection of phencyclidire in body fluids by gas chromatography with surface ionization detection Reviewed
Ishii, A., Seno, H., Kumazawa, T., Nishikawa, M., Watanabe, K., Suzuki, O.
International Journal of Legal Medicine Vol. 108 ( 5 ) page： 244-247 1996
Detection of ethanol in Human body fluids by headspace solid-phase micro extraction(SPME)/capillary gas chromatography(jointly authored) Reviewed
Kumazawa, T., Seno, H., Lee, X.-P., Ishii, A., Suzuki, O., Sato, K.
Chromatographia Vol. 43 ( 7-8 ) page： 393-397 1996
Drawings by an autistic adult chronicling a day in his childhood(jointly authored) Reviewed
Ishii, T., Ishii, A., Ishii, T., Sugiyama, T.
Visual Art Research Vol. 22 ( 2 ) page： 47-55 1996
Simple clean-up of methanphetamine and amphetamine in human urine by direct-immersion solid phase micro extraction(DI-SPME) Reviewed
Ishii, A., Seno, H., Kumazawa, T., Nishikawa, M., Watanabe, K., Hattori, H.,Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 14 ( 3 ) page： 228-232 1996
Reduction of pyrroloquinoline quinone by DT-diaphorase from Clostridium Kluyveri(jointly anthored) Reviewed
Kumazawa, T., Suzuki, O., Seno, H., Ishii, A., Sato, K.
Biochemical Archives Vol. 12 page： 201-206 1996
Sensitive quantitation of clozapine in body fluids by gas chromatography with surface ionization detection Reviewed
Ishii, A., Seno, H., Kumazawa, T., Nishikawa, M., Watanabe, K., Hatori, H., Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 14 ( 3 ) page： 215-220 1996
Analyses of drugs and poisous in legal medicine (jointly authored) Invited Reviewed
Journal of the Mass Spectrometry Society of Japan Vol. 44 ( 3 ) page： 321-333 1996
Detection of some phenothiazines by headspace solid phase microextraction and gas chromatography (jointly authored) Reviewed
Seno, H., Kumazawa, T., Ishii, A., Nishikawa, M., Watanabe, K., Hattori, H., Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 14 ( 1 ) page： 30-34 1996
Analytical Toxicology (jointly authored) Invited Reviewed
Suzuki, O., Seno, H., Ishii, A.
Forensic Science International Vol. 80 ( 1.2 ) page： 137-146 1996
Simple extraction of phencyclidine from human body fluids by headspace solid-phase microextraction(SPME) Reviewed
Ishii, A., Seno, H., Kumazawa, T., Watanabe, K., Hattori, H.,Suzuki, O.
Chromatographia Vol. 43 ( 5-6 ) page： 331-333 1996
Extraction of local anaesthetics from human blood by direct immersion-solid phase micro extraction(SPME)(jointly authored) Invited Reviewed
Kumazawa, T., Sato, K., Seno, H., Ishii, A., Suzuki, O.
Chromatographia Vol. 43 ( 1-2 ) page： 59-62 1996
Determination of some carbamate pesticides in human body fluids by headspace solid phase micro extraction and gas chromatography Reviewed
Seno, H., Kumazawa, T., Ishii, A., Nishikawa, M., Watanabe, K., Hattori, H., Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 14 ( 3 ) page： 199-203 1996
Sensitive detection of Strychnine in biological samples by gas chromatography with surface ionization detection Reviewed
Ishii, A., Hattori, H., Seno, H., Kumazawa, T., Suzuki, O.
Journal of Forensic Sciences Vol. 40 ( 3 ) page： 483-485 1995
Detection of maperidine (pethidine) in human blood and urine by headshace solid phase microextraction and gas chromatography (jointly authored)
Japanese Journal of Forensic Toxicology Vol. 13 ( 3 ) page： 211 1995
Detection of cocaine in human urine by solid-phase microexraction and capillary gas chromatography with nitrogen-phosphorus detection (jointly authored) Reviewed
Kumazawa, T., Watanabe, K., Sato, K., Seno, H., Ishii, A., Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 13 ( 3 ) page： 207-210 1995
Levels of pyrrologuinoline guinone in various foods (joiutly authored) Reviewed
Kumazawa, T., Sato, K., Seno, H., Ishii, A., Suzuki, O.
Bichemical Jourhal Vol. 307 page： 331-333 1995
Capilbty gas chromatograhy with four different detectors for dinitroaniline herbicdes in human body fluids (jointly authored)
Journal of Analytical Toxicology Vol. 19 page： 95 1995
Gas chromatography with surface ionization detection: a highly seusitius metnod for detormining undevivatized codeine and dihydrocodeine in body fluids (jointly authored)
Journal of Chromatograpny B Vol. 673 ( 2 ) page： 189 1995
Detection of ten local anaesthetics in human blood using solid-phase mictroextraction(SPME) and capillary gas chromatography (jointly authored)
Japanese Journal of Forensic Toxicology Vol. 13 ( 3 ) page： 182 1995
Simple extraction of tricyclic antidepressants in human urine by headspace solid-phase microextraction (SPME) (jointly authored)
Japanese Journal of Forensic Toxicology Vol. 13 ( 1 ) page： 25 1995
Positive-and negative-ion mass spectrometry of pyrazolones and pyrazolidines (jointly authored) Reviewed
Seno H, Kumazawa T, Ishii A, Watanabe K, Suzuki O.
Japanese Journal of Forensic Toxicology Vol. 12 ( 3 ) page： 213 1994
Determination of diltiazem in body fluids by gas chromatography with surface ionization detection (jointly authored) Reviewed
Japanese Journal of Forensic Toxicology Vol. 12 ( 3 ) page： 247 1994
Determination of cocaine in body fluids by gas chromatography with surface ionization detection : comparison with nitrogen-phosphorus detection (jointly authored) Reviewed
Hattori, H., Kurono, S., Kimura, M., Ishii, A., Suzuki, O. and Yamada, T.
Japanese Journal of Forensic Toxicology Vol. 12 ( 1 ) page： 26-32 1994
Determination of trihexyphenidyl in body fluids by gas chromatography with surface ionization detection
Japanese Journal of Forensic Toxicology Vol. 12 ( 3 ) page： 241 1994
Positive-and negative-ion mass spectrometry of seven dinitroaniline herbicides (jointly authored) Reviewed
Kumazawa T, Sato K, Seno H, Ishii A, Suzuki O.
Japanese Jounal of Forensic Toxicology Vol. 12 ( 3 ) page： 228 1994
Determination of tertiary amino antitussives in Body Fluids by Gas Chromatography with Surface Ionization Detection Reviewed
Ishii, A., Seno, H., Kumazawa, T. and Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 11 ( 3 ) page： 176-181 1993
Analyses of Quinolone Antimicrobials in Human Plasma by Capillary High-Performance Liquid Chromatography/Fast Atom Bombardment Mass Spectrometry (jointly authored) Reviewed
Hattori, H., Suzuki, O., Seno, H., Ishii, A. and Yamada, T.
Japanese Journal of Forensic Toxicology Vol. 11 ( 3 ) page： 166-175 1993
Determination of Some Butyrophenones in Body Fluids by Gas Chromatography with Surface Ionization Detection (jointly authored) Reviewed
Seno, H., Kumazawa, T., Ishii, A., Sato, K. and Suzuki, O.
Japanese Journal of Legal Medicine Vol. 47 ( 5 ) page： 367-371 1993
Determination of Aminopyrine in Body Fluids by Gas Chromatography with Surface Ionization Detection Reviewed
Ishii, A., Hattori, H., Seno, H., Kumazawa, T., Suzuki, O.
Japanese Journal of Forensic Toxicology Vol. 11 ( 3 ) page： 182-186 1993
Positive and Negative ion mass spectrometry of ten xanthine derivatives and their rapid clean-up with Sep-Pak C18 cartridges from biological samples (jointly authored) Reviewed
Kumazawa, T., Sato, K., Seno, H., Ishii, A. and Suzuki O.
Forensic Science International Vol. 68 page： 53-57 1993
Expression of two forms of dopamine-β-hydroxylase in COS cells. Reviewed
Ishii, A., Kobayashi, K., Kiuchi, K. and Nagatsu, T.
Neuroscience Letters Vol. 125 page： 25-28 1991
The newly synthesized Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells (jointly authored) Reviewed
Sumi, M., Kiuchi, K., Ishikawa, T., Ishii, A., Hagiwara, M., Nagatsu, T. and Hidaka, H.
Biochemical and Biophysical Research Communication Vol. 181 page： 968-975 1991
A selective Ca2+/calmodulin-dependent protein kinase II infibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells Reviewed
. Ishii, A., Kiuchi, K., Kobayashi, R., Sumi, M., Hidaka, H. and Nagatsu, T.
Biochemical and Biophysical Research Communication Vol. 176 page： 1052-1056 1991
Right-left asynmetry tyrosine hydroxylase in rat median eminence : influence of baroreflex nerves (jointly authored) Reviewed
Alexander, N., Kaneda, N., Ishii, A., Mogi, M., Harada, M. and Nagatsu, T.
Brain Research Vol. 109 page： 282 1990
Effect of (6R)-and (6S)-Tetrahydrobiopterin on L, 3,4-dihydrophenylalanine(DOPA) Formation in NRK fibroblasts transfected with human tyrosine hydroxylase type 2cDNA. Reviewed
Ishii, A., Hagihara, M., Matsuura, S., Uchida, K., Kiuchi, K., Kaneda, N., Toya, S., Kohsaka, S. and Nagatsu, T.
Neurochemistry International Vol. 17 ( 4 ) page： 625-632 1990
Ferrous ion actirates the less active form of human adrenal tyrosine hydroxylase Reviewed
Ishii, A., Kiuchi, K., Matsuyama, M., Satake, T. and Nagatsu, T.
Neurochemistry International Vol. 16 ( 1 ) page： 59-64 1990
Tetrahydrobiopterin-dependent production of L-DOPA in NRK fibrablasts transfected with tyrosine hydroxylase cDNA : future use for intracerelral grafting (jointly authored) Reviewed
Uchida, K., Ishii, A., Kaneda, N., Toya, S., Nagatsu, T. and Kohsaka, S.
Neuroscience Letters Vol. 109 page： 282-286 1990
Expression of four types of human tyrosine hydroxylase in COS cells Reviewed
Kobayashi, K., Kiuchi, K., Ishii, A., Kaneda, N., Kurosawa, Y., Fujita, K. and Nagatsu, T.
FEBS Letters Vol. 238 ( 2 ) page： 431-434 1988
火災便覧 Reviewed
（ Role： Contributor , 6・2・1 (3) 火災による死因の判断）
共立出版 2018.11 （ ISBN:978-4-320-07721-8 ）
薬毒物情婦インデックス
（ Role： Joint author）
日本医事新報社 2014.11 （ ISBN:978-4-7849-4151-3 ）
Section 8-2-04. Surface Ionization and its application to GC-MS
A Ishii, O Suzuki, Y Katsumata（ Role： Joint author）
Elsevier Science Ltd. 2006 （ ISBN:978-0-08-043847-4 ）
II.7.7. Diazine and triazne herbicides. Drugs and Poisons in Humans. A Hadnbook of Practical Analysis (eds. Suzuki O. and Watanabe K.)
Ishii, A., Katsumata, Y.（ Role： Joint author）
Springer-Verlag, Berlin Heidelberg 2005
II.2.8. Phencyclidine. Drugs and Poisons in Humans. A Hadnbook of Practical Analysis (eds. Suzuki O. and Watanabe K.)
Ishii, A., Katsumata, Y.（ Role： Joint author）
Springer-Verlag, Berlin Heidelberg 2005
II.3.1. Phenothiaznes. Drugs and Poisons in Humans. A Hadnbook of Practical Analysis (eds. Suzuki O. and Watanabe K.)
Ishii, A., Katsumata, Y.（ Role： Joint author）
Springer-Verlag, Berlin Heidelberg 2005
ダイアジン・トリアジン系除草剤．「薬毒物分析実践ハンドブック」鈴木 修、屋敷幹雄編集
石井 晃，勝又義直（ Role： Joint author）
じほう社 2002
フェノチアジン系薬物．「薬毒物分析実践ハンドブック」鈴木 修、屋敷幹雄編集
石井 晃，勝又義直（ Role： Joint author）
じほう社 2002
4.15 酵素 「感情障害 基礎と臨床」 笠原 嘉、松下正明、岸本英爾 編集
石井 晃，永津俊治（ Role： Sole author）
感情障害-基礎と臨床- 1997
Gas chromatography with surface ionization detection for determination of abused drugs Advances in legal medicine 3
Ishii, A., Seno, H., Hattori, H., Watanabe, K., Suzuki, O（ Role： Joint author）
Yoyodo Printings 1997
Genes of human catecholamine-synthesizing enzymes. Parkinson's Disease. From Clinical Aspects to Molecular Basis (Nagatsu, T., Narabayashi, H., Yoshida, M. eds.)
Nagatsu, T., Kaneda, N., Kobayashi, K., Ichinose, H., Sasaoka, T., Ishii, A., Sumi, C., Kiuchi, K., Fujita, K., Kurosawa, Y.（ Role： Joint author）
Springer Verlag 1991
７−１１ ドーパミン-β-ヒドロキシラーゼ. 日本生化学会編 新生化学実験講座 第１１巻「神経生化学」
永津俊治，石井 晃（ Role： Joint author）
東京化学同人 1990
７−８ チロシンヒドロキシラーゼ. 日本生化学会編 新生化学実験講座 第１１巻「神経生化学」
永津俊治，石井 晃（ Role： Sole author）
東京化学同人 1990
Molecular genetic approaches to the study of human catecholamine-synthesiziy euzymes (jointly authored)
T Nagatsu, N Kaneda, K Kobayashi, H Ichinose, T Sasaoka, Ishii A, K Kiuchi, Y Kurosawa, K Fujita（ Role： Joint author）
Bioinformatics (Elsevier Science Publishers B. V. ) 1989
The road not taken: my career as a forensic pathologist and a forensic toxicologist Invited International conference
A Ishii
TIAFT Online Educational Symposium 2020.12.15 The International Association of Forensic Toxicologists
終末期医療をめぐる生命倫理
日本における検視と法医解剖－どのような症例が解剖の対象となるか－
大容量導入質量分析による超高感度分析法
2006.4 - 2008.3
上原記念生命科学財団 上原記念生命科学財団研究助成金
Grant type：Competitive
培養細胞を用いた免疫機能への薬毒物の影響ー好中球の遊走を指標として−
2006.4 - 2007.3
日本私学振興財団 私立大学教育研究高度化推進特別補助
Authorship：Coinvestigator(s) Grant type：Competitive
包括的薬毒物スクリーニングシステムの構築
2005.4 - 2006.3
日本私学振興財団 学術研究振興資金
Authorship：Principal investigator Grant type：Competitive
確度の高い死因判定のための総合的解剖システムの確立
2005.4 - 2006.3
日本私学振興事業団 私立大学等研究設備等補助金
Grant type：Competitive
オーブン冷却捕獲法による体液中揮発性薬毒物の高感度分析
1999.4 - 2000.3
上原記念財団 研究奨励金
Grant type：Competitive
Grant number：23K18387 2023.6 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)
Authorship：Principal investigator
Grant amount：\6110000 （ Direct Cost: \4700000 、 Indirect Cost：\1410000 ）
Grant number：23K09762 2023.4 - 2026.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Authorship：Coinvestigator(s)
Grant number：19K22756 2019.6 - 2023.3
科学研究費助成事業 挑戦的研究(萌芽)
石井 晃, 名取 雄人
Authorship：Principal investigator Grant type：Competitive
Grant amount：\6240000 （ Direct Cost: \4800000 、 Indirect Cost：\1440000 ）
本研究においては、ペプチド質量分析に習熟した研究協力者と共に、最新の質量分析技術を駆使して、熱中症等で上昇する尿中ミオグロビン、頸部圧迫で上昇する可能性がある血液中サイログロブリン、心不全のマーカーである血液中NT-proBNPなどについて、分解したペプチドをターゲットとした同定・定量法を確立する。同時に、死後変動の再検討も行い、死後経過時間の長い死体におけるこれらタンパク及び分解ペプチドマーカーの高感度かつ正確な同定・定量を試みる。最終的には、法医鑑定に資する体液中分解ペプチドマーカーを確立する。
本研究では、生体試料における目的タンパクを定量し、次いで、実検体で切断されているペプチドフラグメントを同定し、法医診断に資するタンパク(ペプチド)マーカーの探索を行うことを目的とする。対象となるタンパクとしては、熱中症で上昇するミオグロビン、心不全で上昇するNT-proBNPが挙げられる。
本年度は、昨年度に引き続き、標準尿サンプルからのミオグロビンの検出条件について検討した。法医鑑定においては、多くのサンプルが腐敗変性の影響を受けていることを勘案し、新鮮尿及び２週間室温に放置して腐敗させた尿サンプル0.25 mLにヒト組み換えミオグロビンを、終濃度10 ng/mLになるように添加し、さらに1 mlのアセトニトリルを添加して攪拌後、氷上で15分静置し、その後1,700 gで15分遠心し、沈殿を25 microLの蒸留水ないしトリプシン溶液を添加し、直ちに2×サンプルバッファーを添加して加熱変性したものを未処理サンプル、37度の水浴で60分処理後、25 microLのサンプルバッファーを添加して加熱変性したものを処理サンプルとし、SDS-PAGEを行った。その後、Western blotを行い、抗ミオグロビン抗体による染色を行った。すると、処理サンプルでミオグロビンのバンドが認められなかったのは予想通りであったが、腐敗尿では、未処理サンプルでもミオグロビンのバンドは認められなかった。そこで、同様の実験を、最大200 ng/mLまでミオグロビンを添加した尿で行ったところ、腐敗尿では、感度限界が5分の1程度に低下することがわかった。今後、種々の腐敗条件で同様の結果が得られるかを検討し、再現性の高いミオグロビン検出条件の最適化を試みる。
本年度も、コロナ禍による登校制限などが重なり、尿中ミオグロビンの電気泳動実験が遅延したため。
腐敗尿におけるミオグロビンの検出限界の低下は、ミオグロビン分子が、腐敗尿に含まれるタンパク成分ないし低分子物質に吸着する可能性が考えられる。昨年、免疫沈降法はミオグロビンの濃縮に不利であるという結果がでたものの、免疫沈降法を再度採用する可能性もある。また、腐敗尿を従来解剖時に依頼していた検査法で検査し、データを比較することも予定している。
高感度新規胆汁酸分析法を用いたNASH肝線維化に関わる胆汁酸種の解明
Grant number：19K11653 2019.4 - 2023.3
科学研究費助成事業 基盤研究(C)
浅野 友美, 那須 民江, 石井 晃, 北森 一哉
Authorship：Coinvestigator(s)
より高感度に胆汁酸分析が可能なnano LC/MS/MSと呼ばれる新規質量分析法を用い、NASH肝線維化の発症および重症化に関わる胆汁酸種や組成を明らかにする。高脂肪・高コレステロール（HFC）食の摂取により、NASH進展を示すモデルラットSHRSP5/Dmcrの肝線維化には、肝臓中の胆汁酸種の毒性強度や組成が強く影響する。本研究では、発症や重症化に関わる胆汁酸種や組成変化を捉えるため、SHRSP5/Dmcrに加え、HFC食摂取により肝線維化の重症度が異なる系統基ラットSHRSPおよびWKYを用い、3系統のラットの肝線維化重症度の差と胆汁酸組成の差から、肝線維化に関与する胆汁酸を明らかにする。
令和3年度調整済みの3系統ラットの肝臓中胆汁酸を分析した。
データの解析は学外の専用解析ソフトが必要であり、解析ソフトの更新の都合と新型コロナ禍の影響により、データ解析を十分に進めることができなかった。このため、令和3年度は分析に留まった。
3系統ラットの肝臓中胆汁酸の分析は終了したものの、データ解析が学外施設設置の機器でないとできない状況であった。しかし、新型コロナ禍の影響により出向を自粛したためデータ解析に遅れが生じた。
脂肪・高コレステロール（HFC）食の摂取によりNASH病態を示すSHRSP5/Dmcrに加え、同食餌の摂取により肝線維化の重症度の異なる系統基ラットであるSHRSPおよびWKYラットの3系統ラットの肝臓中胆汁酸をプロファイリングし、肝線維化や重症化に関わる胆汁酸種や胆汁酸組成との関連を明らかにする。
Grant number：18H03064 2018.4 - 2021.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Ishii Akira
Authorship：Principal investigator
Grant amount：\16380000 （ Direct Cost: \12600000 、 Indirect Cost：\3780000 ）
The purpose of the present study is to develop methods for sensitive identification and precise quantification of natural toxins in human biological specimens using deuterium labeled natural toxins by deuterium exchange reactions. Although we have not obtained deuterium labeled natural toxins, we have developed two methods for screening, identifying and quantification natural toxins in human biological specimens: a screening system for 56 natural toxins by liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (LC-QTOFMS), and a sensitive quantification method for 12 plant toxins by LC-tandem mass spectrometry, combined with simple solid-phase extraction.
最新質量分析計による体液中危険ドラッグの検出・同定法の開発及び学際的検討 International coauthorship
Grant number：15H02530 2015.4 - 2018.3
科学研究費補助金 基盤研究(A)
Authorship：Principal investigator Grant type：Competitive
Metabolic profiling analysis of rat administered natural toxins
Grant number：15K08889 2015.4 - 2018.3
OGAWA Tadashi
Authorship：Coinvestigator(s) Grant type：Competitive
For the purpose of clarifying influences, toxicities and action mechanisms given by administration of natural toxins in the living body, internal metabolism profiling analyses were worked on rat. Even though establishment of connected evaluation method of metabolomics analysis and iTRAQ protein expression analysis is uncompleted, various fundamental data of metabolic profiling analyses of rat administered natural toxins were obtained by GC-MS/MS and LC-QTOF-MS.
Application of novel mass spectrometric techniques for highly sensitive, specific and speedy identification of new psychoactive substances in human specimens
Grant number：15H02530 2015.4 - 2018.3
Ishii Akira
Authorship：Principal investigator Grant type：Competitive
Grant amount：\25870000 （ Direct Cost: \19900000 、 Indirect Cost：\5970000 ）
The aim of this project is to develop simple and comprehensive methods for determining novel abused drugs including synthetic cannabinoids by combining ultra-sensitive and/or highly specific mass spectrometers, and conventional mass spectrometers. We developed a simple method for determining several synthetic cannabinoids and their metabolites using a high-performance liquid chromatography-quadrupole time-of-flight mass spectrometer (LC-QTOFMS). The combination of an LC-QTOFMS and an LC-QTrap enabled the first identification of 5-fluoro-ADB (5-F-ADB) in the blood of a fatal intoxication case of 5-F-ADB and diphenidine. We then proposed possible metabolic pathways of the compounds. We are now investigating the difference of 5-F-ADB levels among organs in which the expression levels of carboxyesterase differ.
New prevention strategies for non-alcoholic steatohepatitis - a study on the importance of blood pressure and nutritional management
Grant number：15H04788 2015.4 - 2018.3
NASU Tamie
Authorship：Coinvestigator(s) Grant type：Competitive
We investigated the mechanism that underlies the progression of hypertension-associated NASH by comparing differences in HFC diet-induced NASH among hypertensive SHR and SHRSP5/Dmcr, and normotensive WKY. The diet induced severe NASH in the hypertensive rats, whereas it only caused mild NASH in the normotensive rats. Increased activation of TGFβ/MAPK pathway was observed in the hypertensive rats; it suppressed nrf2 pathway in the hypertensive rats and led to lower increases in the hepatic level of HO-1. These signaling pathways might play crucial roles in the development of hypertension-associated NASH.
We also investigated whether antihypertensive drug suppress HFC-induced NASH in hypertensive SHR rats. It suppressed HFC-induced NASH in the liver of SHR rats. It significantly suppressed HFC-induced increases of inflammation- and fibrosis-related molecular markers. Thus, intervention of antihypertensive drug might be important in the prevention of NASH.
バイオマーカーとしての胆汁酸の法医学的応用
Grant number：24659337 2012.4 - 2016.3
科学研究費補助金
Authorship：Principal investigator
新しいフーリエ変換ーリニアイオントラップ質量分析計の法医学への応用
Grant number：23390183 2011.4 - 2015.8
科学研究費補助金 基盤研究(B)
Authorship：Principal investigator Grant type：Competitive
ナノスケール高速液体クロマトグラフィー/質量分析計の法医学への応用
Grant number：18209025 2006.4 - 2010.3
科学研究費補助金 基盤研究(A)
Authorship：Principal investigator Grant type：Competitive
固相マイクロ抽出法による新規乱用薬物のスクリーニング分析
Grant number：17590587 2005.4 - 2007.3
科学研究費補助金 基盤研究(C)
浜島 誠
Authorship：Coinvestigator(s) Grant type：Competitive
薬毒物の作用機序の解析に有用な新しい質量分析法
Grant number：15659156 2003.4 - 2006.3
科学研究費補助金
Authorship：Principal investigator Grant type：Competitive
Application of high-performance liquid chromatography/laser spray mass spectrometry to legal medicine
Grant number：14207023 2002.4 - 2006.3
Grant-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(A)
Authorship：Principal investigator Grant type：Competitive
Rapid screening of inorganic poisons by column-switching ion chromatography
Grant number：13557037 2001.4 - 2004.3
Grant-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(B)
Authorship：Principal investigator Grant type：Competitive
Sensitive analysis for drugs-of-abuse in human body fluids by GC/MS/MS
Grant number：12670391 2000.4 - 2002.3
Grant-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(C)
Authorship：Principal investigator Grant type：Competitive
New approach for drug monitoring by using human sweat secreted
Grant number：11559008 1999.4 - 2002.3
Grant-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(B)
Authorship：Coinvestigator(s)
Establishment of forensic molecular genetic analyzing method using the rapid detection allele-specific MVR-PCR
Grant number：11670411 1999.4 - 2001.3
Grant-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(C)
Authorship：Coinvestigator(s) Grant type：Competitive
HPLC/タンデムMSによるドーピング薬物の迅速高感度検出法の確立
Grant number：10770188 1998.4 - 2000.3
科学研究費補助金 奨励研究（A）
Authorship：Principal investigator Grant type：Competitive
Development of surface ionization organic mass spectrometer (SIOMS) for the application to forensic toxicology
Grant number：09307008 1997.4 - 2000.3
Grant-in-Aid for Scientific Research Grant-in-Aid for Scientific Research(A)
Authorship：Coinvestigator(s) Grant type：Competitive
マイクロ固相抽出(SPME)法による体液中乱用薬物の高感度検出法
Grant number：08770308 1996.4 - 1997.3
科学研究費補助金 奨励研究(A)
Authorship：Principal investigator
Molecular mechanism of alcoholism : Ethanol and cell signaling
Grant number：08044264 1996.4 - 1997.3
Grant-in-Aid for Scientific Research
Authorship：Coinvestigator(s) Grant type：Competitive
トリカブト毒成分(アコニチン)HPLC/MSによる高感度分析
Grant number：06770317 1994.4 - 1995.3
科学研究費補助金 奨励研究(A)
Authorship：Principal investigator Grant type：Competitive
Legal Medicine (for Medical Students)
2011
法医学(医学部）
2011
Medical Law (YLP)
2011
基礎セミナーB
2011
First Year Seminar B
2011
法医学
2009.4 （名古屋市消防学校）
Level：Other
法医学（中毒）
2009.4 （藤田保健衛生大学医学部）
Level：Undergraduate (specialized)
法医学（中毒）
2009.4 （Kyoto University）
Level：Undergraduate (specialized)
法医学（性・妊娠の法医学）
2009.4 - 2015.3 （昭和大学医学部）
Level：Undergraduate (specialized)
法医学(異常環境）
2008.4 - 2009.3 （浜松医科大学）
