Nagoya University

2012.4 - 2015.3

Nagoya University   Graduate School of Medicine

2012.4 - 2015.3

Nagoya University

2012.3 - 2017.4

Nagoya University   Graduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering   Director in General

2012.3 - 2015.3

名古屋大学総長補佐（創薬科学担当）

2009.4 - 2012.3

Department of Biochemistry Nagoya University Graduate School of Medicine. Professor

2004.9

名古屋大学大学院医学系研究科　助教授

2002.4

名古屋大学大学院医学研究科　助教授（生物化学講座分子生物学：名称変更）

2000.4

名古屋大学医学部　助教授 (第一生化学）

1996.8

名古屋大学医学部　講師 (第一生化学)

1994.5

名古屋大学医学部　助手 (第一生化学)

1993.10

アメリカ国立衛生研究所客員研究員

1990.10

鹿児島大学医学部　助手 (第二生化学)

1990.4

九州大学医学部附属病院医員 (小児外科)

1989.4

鹿児島大学医学部　助手 (第二生化学)

1988.4

九州大学医学部附属病院医員 (小児外科、周産期)

1982.11

福岡市立こども病院医員 (小児外科)

1982.5

JCGG

日本学術会議連携委員   連携会員  

2012 - 2020.9   

Growth Factor Midkine Aggravates Pulmonary Arterial Hypertension via Surface Nucleolin

Kinoshita Daisuke, Shishido Tetsuro, Takahashi Tetsuya, Yokoyama Miyuki, Sugai Takayuki, Watanabe Ken, Tamura Harutoshi, Nishiyama Satoshi, Takahashi Hiroki, Arimoto Takanori, Miyamoto Takuya, Watanabe Tetsu, Kishida Satoshi, Kadomatsu Kenji, Abe Jun-ichi, Takeishi Yasuchika, Konta Tsuneo, Kubota Isao, Watanabe Masafumi

SCIENTIFIC REPORTS   Vol. 10 ( 1 ) page： 10345   2020.6

Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage inMYCN-amplified neuroblastoma cells

Yamashita Ken, Kiyonari Shinichi, Tsubota Shoma, Kishida Satoshi, Sakai Ryuichi, Kadomatsu Kenji

CANCER SCIENCE   Vol. 111 ( 7 ) page： 2431-2439   2020.6

Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase

Hayasaki Takahiro, Ishimoto Takuji, Doke Tomohito, Hirayama Akiyoshi, Soga Tomoyoshi, Furuhashi Kazuhiro, Kato Noritoshi, Kosugi Tomoki, Tsuboi Naotake, Lanaspa Miguel A., Johnson Richard J., Maruyama Shoichi, Kadomatsu Kenji

JOURNAL OF NUTRITIONAL BIOCHEMISTRY   Vol. 71   page： 54-62   2019.9

CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling

Yoshioka Tomoki, Kosugi Tomoki, Masuda Tomohiro, Watanabe Tomoharu, Ryuge Akihiro, Nagaya Hiroshi, Maeda Kayaho, Sato Yuka, Katsuno Takayuki, Kato Noritoshi, Ishimoto Takuji, Yuzawa Yukio, Maruyama Shoichi, Kadomatsu Kenji

AMERICAN JOURNAL OF PATHOLOGY   Vol. 189 ( 7 ) page： 1338-1350   2019.7

Glycan sulfation patterns define autophagy flux at axon tip via PTPR sigma-cortactin axis

Sakamoto Kazuma, Ozaki Tomoya, Ko Yen-Chun, Tsai Cheng-Fang, Gong Yuanhao, Morozumi Masayoshi, Ishikawa Yoshimoto, Uchimura Kenji, Nadanaka Satomi, Kitagawa Hiroshi, Zulueta Medel Manuel L., Bandaru Anandaraju, Tamura Jun-ichi, Hung Shang-Cheng, Kadomatsu Kenji

NATURE CHEMICAL BIOLOGY   Vol. 15 ( 7 ) page： 699-+   2019.7

Compositional analysis of the glycosaminoglycan family in velvet antlers of Sika deer (Cervus nippon) at different growing stages

Takeda-Okuda Naoko, Mizumoto Shuji, Zhang Zui, Kim Soo-Ki, Lee Chi-Ho, Jeon Byong-Tae, Hosaka Yoshinao Z., Kadomatsu Kenji, Yamada Shuhei, Tamura Jun-ichi

GLYCOCONJUGATE JOURNAL   Vol. 36 ( 2 ) page： 127 - 139   2019.4

Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18

Nariai Yuko, Kamino Hiroki, Obayashi Eiji, Kato Hiroaki, Sakashita Gyosuke, Sugiura Tomoko, Migita Kiyoshi, Koga Tomohiro, Kawakami Atsushi, Sakamoto Kazuma, Kadomatsu Kenji, Nakakido Makoto, Tsumoto Kouhei, Urano Takeshi

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS   Vol. 663   page： 71 - 82   2019.3

GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain

Narentuya, Takeda-Uchimura Yoshiko, Foyez Tahmina, Zhang Zui, Akama Tomoya O., Yagi Hirokazu, Kato Koichi, Komatsu Yukio, Kadomatsu Kenji, Uchimura Kenji

SCIENTIFIC REPORTS   Vol. 9 ( 1 ) page： 4387   2019.3

miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury. Reviewed

Funahashi Y, Kato N, Masuda T, Nishio F, Kitai H, Ishimoto T, Kosugi T, Tsuboi N, Matsuda N, Maruyama S, Kadomatsu K.

Lab Invest.     2019.1

Compositional analysis of the glycosaminoglycan family in velvet antlers of Sika deer (Cervus nippon) at different growing stages. Reviewed

Takeda-Okuda N, Mizumoto S, Zhang Z, Kim SK, Lee CH, Jeon BT, Hosaka YZ, Kadomatsu K, Yamada S, Tamura JI.

Glycoconj J.     2019.1

Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18. Reviewed

Nariai Y, Kamino H, Obayashi E, Kato H, Sakashita G, Sugiura T, Migita K, Koga T, Kawakami A, Sakamoto K, Kadomatsu K, Nakakido M, Tsumoto K, Urano T.

Arch Biochem Biophys.   Vol. 663   page： 71-82   2019.1

Technologies to Elucidate Functions of Glycans

Furukawa Koichi, Ohmi Yuhsuke, Kondo Yuji, Ohkawa Yuki, Tajima Orie, Furukawa Keiko, Honke Koichi, Inokuchi Jin-ichi, Gu Jianguo, Kadomatsu Kenji, Nadanaka Satomi, Kitagawa Hiroshi, Nishihara Shoko, Nomura Kazuya, Oka Shogo, Ito Makoto, Kitajima Ken, Natsuka Shunji, Kanagawa Motoi, Ishimizu Takeshi, Fujiyama Kazuhito, Chiba Yasunori, Osada Hiroyuki

GLYCOSCIENCE: BASIC SCIENCE TO APPLICATIONS: INSIGHTS FROM THE JAPAN CONSORTIUM FOR GLYCOBIOLOGY AND GLYCOTECHNOLOGY (JCGG)     page： 87-124   2019

Glycans in Nervous System

Sato Chihiro, Gu Jianguo, Fukuda Tomohiko, Kadomatsu Kenji, Ikenaka Kazuhiro

GLYCOSCIENCE: BASIC SCIENCE TO APPLICATIONS: INSIGHTS FROM THE JAPAN CONSORTIUM FOR GLYCOBIOLOGY AND GLYCOTECHNOLOGY (JCGG)     page： 209-219   2019

Single-cell transcriptomic analysis reveals the early separation of neuroblastoma fate in Th-MYCN mice

Tsubota Shoma, Kishida Satoshi, Kadomatsu Kenji

CANCER SCIENCE   Vol. 109   page： 1112-1112   2018.12

Analysis of the genes which showed synthetic lethal phenotype with BAP1 mutations in malignant mesothelioma cells

Murakami-Tonami Yuko, Kiyonari Shinichi, Tabe Yoko, Kadomatsu Kenji, Miida Takashi, Sekido Yoshitaka

CANCER SCIENCE   Vol. 109   page： 625-625   2018.12

Synthetic lethal genes in MYCN-amplified neuroblastoma cells and their potential for therapeutic application

Kiyonari Shinichi, Kadomatsu Kenji

CANCER SCIENCE   Vol. 109   page： 1028-1028   2018.12

The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases. Reviewed

Mori Y, Masuda T, Kosugi T, Yoshioka T, Hori M, Nagaya H, Maeda K, Sato Y, Kojima H, Kato N, Ishimoto T, Katsuno T, Yuzawa Y, Kadomatsu K, Maruyama S.

Clin. Exp. Nephrol.   Vol. 22 ( 4 ) page： 815-824   2018.8

Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice

Doke Tomohito, Ishimoto Takuji, Hayasaki Takahiro, Ikeda Satsuki, Hasebe Masako, Hirayama Akiyoshi, Soga Tomoyoshi, Kato Noritoshi, Kosugi Tomoki, Tsuboi Naotake, Lanaspa Miguel A., Johnson Richard J., Kadomatsu Kenji, Maruyama Shoichi

METABOLISM-CLINICAL AND EXPERIMENTAL   Vol. 85   page： 161-170   2018.8

Origin and initiation mechanisms of neuroblastoma. Reviewed

Tsubota S, Kadomatsu K.

Cell Tissue Res.   Vol. 372 ( 2 ) page： 211-221   2018.5

Midkine Promotes Atherosclerotic Plaque Formation Through Its Pro-Inflammatory, Angiogenic and Anti-Apoptotic Functions in Apolipoprotein E-Knockout Mice. Reviewed

Takemoto Y, Horiba M, Harada M, Sakamoto K, Takeshita K, Murohara T, Kadomatsu K, Kamiya K.

Circ. J.   Vol. 82 ( 1 ) page： 19-27   2017.12

Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes. Reviewed

Su Z, Kishida S, Tsubota S, Sakamoto K, Cao D, Kiyonari S, Ohira M, Kamijo T, Narita A, Xu Y, Takahashi Y, Kadomatsu K.

Oncotarget   Vol. 8 ( 63 ) page： 106296-106310   2017.11

A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-kB degradation and cell growth suppression in neuroblastoma. Reviewed

Mu Ping., Akashi, T., Lu, F., Kishida, S. and Kadomatsu, K.

Oncogene   Vol. 36 ( 41 ) page： 5745-5756   2017.10

PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma. Reviewed

Tsubota S, Kishida S, Shimamura T, Ohira M, Yamashita S, Cao D, Kiyonari S, Ushijima T, Kadomatsu K.

Cancer Res.   Vol. 77 ( 19 ) page： 5259-5271   2017.10

Mechanisms of axon regeneration: The significance of proteoglycans. Reviewed

Sakamoto K, Kadomatsu K.

Biochim. Biophys. Acta Gen. Subj.   Vol. 1861 ( 10 ) page： 2435-2441   2017.10

Origin and mechanism of neuroblastoma.

Tsubota S, Kadomatsu K.

Oncoscience   Vol. 4 ( 7-8 ) page： 70-72   2017.9

Dual inhibition of P-glycoprotein and midkine may increase therapeutic effects of anticancer drugs. Reviewed

Aynacıoğlu AŞ, Bilir A, Kadomatsu K.

Med. Hypotheses   Vol. 107   page： 26-28   2017.9

Temporally and Spatially Regulated Expression of the Linker Histone H1fx During Mouse Development. Reviewed

Ichihara-Tanaka K, Kadomatsu K, Kishida S.

J. Histochem. Cytochem.   Vol. 65 ( 9 ) page： 513-530   2017.9

Differential activation of neuronal and glial STAT3 in the spinal cord of the SOD1G93A mouse model of amyotrophic lateral sclerosis. Reviewed

Ohgomori T, Yamasaki R, Takeuchi H, Kadomatsu K, Kira JI, Jinno S.

Eur. J. Neurosci.   Vol. 46 ( 4 ) page： 2001-2014   2017.8

Involvement of midkine in the development of pulmonary fibrosis. Reviewed

Misa K, Tanino Y, Wang X, Nikaido T, Kikuchi M, Sato Y, Togawa R, Tanino M, Tanaka S, Kadomatsu K, Munakata M.

Physiol. Rep.   Vol. 5 ( 16 )   2017.8

Efficacy of urinary midkine as a biomarker in patients with acute kidney injury.

Hayashi H, Sato W, Kosugi T, Nishimura K, Sugiyama D, Asano N, Ikematsu S, Komori K, Nishiwaki K, Kadomatsu K, Matsuo S, Maruyama S, Yuzawa Y.

Clin. Exp. Nephrol.   Vol. 21 ( 4 ) page： 597-607   2017.8

Differential activation of neuronal and glial STAT3 in the spinal cord of the SOD1G93A mouse model of amyotrophic lateral sclerosis.

Ohgomori T, Yamasaki R, Takeuchi H, Kadomatsu K, Kira JI, Jinno S.

Neuroscience   Vol. 356   page： 114-124   2017.7

Neuroblastoma stem cells and CFC1. Reviewed

Tsubota S, Kadomatsu K.

Oncotarget   Vol. 8 ( 28 ) page： 45032-45033   2017.7

Sulfatase 2 Modulates Fate Change from Motor Neurons to Oligodendrocyte Precursor Cells through Coordinated Regulation of Shh Signaling with Sulfatase 1. Reviewed

Jiang W, Ishino Y, Hashimoto H, Keino-Masu K, Masu M, Uchimura K, Kadomatsu K, Yoshimura T, Ikenaka K.

Dev. Neurosci.   Vol. 39 ( 5 ) page： 361-374   2017.5

Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.

Scilabra SD, Yamamoto K, Pigoni M, Sakamoto K, Müller SA, Papadopoulou A, Lichtenthaler SF, Troeberg L, Nagase H, Kadomatsu K.

Matrix Biol.   Vol. 59   page： 69-79   2017.5

INDUCTION OF IMMUNOSUPPRESSIVE MICRO-RNA IN SPLEEN ATTENUATES SEPSIS INDUCED ACUTE KIDNEY INJURY

Funahashi Yoshio, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Kadomatsu Kenji, Maruyama Shoichi

NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 32   page： .   2017.5

Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology. Reviewed

Zhang Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, Narentuya, Akatsu H, Nishitsuji K, Michikawa M, Wyss-Coray T, Kadomatsu K, Uchimura K.

Proc. Natl. Acad. Sci. U S A   Vol. 114 ( 14 ) page： E2947-E2954   2017.4

Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis. Reviewed

Masuda T, Maeda K, Sato W, Kosugi T, Sato Y, Kojima H, Kato N, Ishimoto T, Tsuboi N, Uchimura K, Yuzawa Y, Maruyama S, Kadomatsu K.

Am. J. Pathol.   Vol. 187 ( 4 ) page： 740-751   2017.4

Correction of spherical aberration in multi-focal multiphoton microscopy with spatial light modulator.

Matsumoto N, Konno A, Ohbayashi Y, Inoue T, Matsumoto A, Uchimura K, Kadomatsu K, Okazaki S.

Opt. Express   Vol. 25 ( 6 ) page： 7055-7068   2017.3

GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system. Reviewed

Yoshimura T, Hayashi A, Handa-Narumi M, Yagi H, Ohno N, Koike T, Yamaguchi Y, Uchimura K, Kadomatsu K, Sedzik J, Kitamura K, Kato K, Trapp BD, Baba H, Ikenaka K.

Sci. Rep.   Vol. 7   page： 42257   2017.2

Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma. Reviewed

Ho WL, Hsu WM, Huang MC, Kadomatsu K, Nakagawara A.

J. Hematol. Oncol.   Vol. 9 ( 1 ) page： 100   2016.9

SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells.

Murakami-Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, Komata Y, Jan Koster, Takeuchi I, Kondo Y, Maeda T, Sekido Y, Murakami H, Kadomatsu K.

Sci. Rep.   Vol. 6   page： 31615   2016.8

Nogo receptor 1 is expressed in both primary cultured glial cells and neurons.

Ukai J, Imagama S, Ohgomori T, Ito Z, Ando K, Ishiguro N, Kadomatsu K.

Nagoya J. Med. Sci.   Vol. 3 ( 78 ) page： 303-311   2016.8

Reduced molecular size and altered disaccharide composition of cerebral chondroitin sulfate upon Alzheimer's pathogenesis in mice. Reviewed

Zhang Z, Ohtake-Niimi S, Kadomatsu K, Uchimura K.

Nagoya J. Med. Sci.   Vol. 78 ( 3 ) page： 293-301   2016.8

Comparative morphometric analysis of microglia in the spinal cord of SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis.

Ohgomori T, Yamada J, Takeuchi H, Kadomatsu K, Jinno S.

Eur. J. Neurosci.   Vol. 10 ( 43 ) page： 1340-1351   2016.5

Midkine Deteriorates Cardiac Remodeling via Epidermal Growth Factor Receptor Signaling in Chronic Kidney Disease.

Honda Y, Shishido T, Takahashi T, Watanabe T, Netsu S, Kinoshita D, Narumi T, Kadowaki S, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Kishida S, Kadomatsu K, Takeishi Y, Kubota I.

Hypertension   Vol. 5 ( 67 ) page： 857-865   2016.5

Basigin Promotes Cardiac Fibrosis and Failure in Response to Chronic Pressure Overload in Mice.

Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Spinale FG, Kadomatsu K, Shimokawa H

Arterioscler. Thromb. Vasc. Biol.   Vol. 4 ( 36 ) page： 636-646   2016.4

Keratan Sulfate Regulates the Switch from Motor Neuron to Oligodendrocyte Generation During Development of the Mouse Spinal Cord.

Neurochem. Res.   Vol. 41 ( 1-2 ) page： 450-462   2016.2

Exogenous midkine administration prevents cardiac remodeling in pacing-induced congestive heart failure of rabbits.

Harada M, Hojo M, Kamiya K, Kadomatsu K, Murohara T, Kodama I, Horiba M.

Heart Vessels   Vol. 1 ( 31 ) page： 96-104   2016.1

Requirement of keratan sulfate proteoglycan phosphacan with a specific sulfation pattern for critical period plasticity in the visual cortex. Reviewed

Takeda-Uchimura Y, Uchimura K, Sugimura T, Yanagawa Y, Kawasaki T, Komatsu Y, Kadomatsu K.

Exp. Neurol.   Vol. 274 ( Pt B ) page： 145-155   2015.12

Introduction to glyco-neuroscience.

Exp. Neurol.   Vol. 274 ( Pt B ) page： 89   2015.12

Time-dependent localization of high- and low-sulfated keratan sulfates in the song nuclei of developing zebra finches.

Fujimoto H, Ohgomori T, Abe K, Uchimura K, Kadomatsu K, Jinno S.

Eur. J. Neurosci.   Vol. 42 ( 9 ) page： 2716-2725   2015.11

The 1,2-diaminocyclohexane carrier ligand in oxaliplatin induces p53-dependent transcriptional repression of factors involved in thymidylate biosynthesis. Reviewed

Kiyonari S, Iimori M, Matsuoka K, Watanabe S, Morikawa-Ichinose T, Miura D, Niimi S, Saeki H, Tokunaga E, Oki E, Morita M, Kadomatsu K, Maehara Y, Kitao H.

Mol. Cancer Ther.   Vol. 14 ( 10 ) page： 2332-2342   2015.10

Microglial Keratan Sulfate Epitope Elicits in Central Nervous Tissues of Transgenic Model Mice and Patients with Amyotrophic Lateral Sclerosis.

Foyez T, Takeda-Uchimura Y, Ishigaki S, Narentuya, Zhang Z, Sobue G, Kadomatsu K, Uchimura K.

Am. J. Pathol.   Vol. 185 ( 11 ) page： 3053-3065   2015.9

Keratan sulfate exacerbates experimental autoimmune encephalomyelitis.

Ueno R, Miyamoto K, Tanaka N, Moriguchi K, Kadomatsu K, Kusunoki S.

J. Neurosci. Res.   Vol. 93 ( 12 ) page： 1874-1880   2015.9

Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids. Reviewed

Sato Y, Sato W, Maruyama S, Wilcox CS, Falck JR, Masuda T, Kosugi T, Kojima H, Maeda K, Furuhashi K, Ando M, Imai E, Matsuo S, Kadomatsu K.

J. Am. Soc. Nephrol.   Vol. 26 ( 8 ) page： 1806-1815   2015.8

CD147 (EMMPRIN/Basigin) in kidney diseases: from an inflammation and immune system viewpoint. Reviewed

Kosugi T, Maeda K, Sato W, Maruyama S, Kadomatsu K.

Nephrol. Dial. Transplant   Vol. 30 ( 7 ) page： 1097-1103   2015.7

Reductions of docosahexaenoic acid-containing phosphatidylcholine levels in the anterior horn of an ALS mouse model. Reviewed

Arima H, Omura T, Hayasaka T, Masaki N, Hanada M, Xu D, Banno T, Kobayashi K, Takeuchi H, Kadomatsu K, Matsuyama Y, Setou M.

Neuroscience   Vol. 2 ( 297 ) page： 127-136   2015.6

A proliferation-inducing ligand sustains the proliferation of human naïve (CD27-) B cells and mediates their differentiation into long-lived plasma cells in vitro via transmembrane activator and calcium modulator and cyclophilin ligand interactor and B-cell mature antigen. Reviewed

Matsuda Y, Haneda M, Kadomatsu K, Kobayashi T.

Cell Immunol.   Vol. 295 ( 2 ) page： 127-136   2015.6

EML4 promotes the loading of NUDC to the spindle for mitotic progression. Reviewed

Chen D, Ito S, Yuan H, Hyodo T, Kadomatsu K, Hamaguchi M, Senga T.

Cell Cycle   Vol. 14 ( 10 ) page： 1529-1539   2015.5

CD147/Basigin limits lupus nephritis and TH 17 cell differentiation by inhibiting the IL-6/STAT3 pathway. Reviewed

Maeda K, Kosugi T, Sato W, Kojima H, Sato Y, Kamimura D, Kato N, Tsuboi N, Yuzawa Y, Matsuo S, Murakami M, Maruyama S, Kadomatsu K.

Arthritis Rheumatol.   Vol. 67 ( 8 ) page： 2185-2195   2015.5

A combination of keratan sulfate digestion and rehabilitation promotes anatomical plasticity after rat spinal cord injury. Reviewed

Ishikawa Y, Imagama S, Ohgomori T, Ishiguro N, Kadomatsu K.

Neurosci. Lett.   Vol. 593   page： 13-18   2015.4

NeuroD1 promotes neuroblastoma cell growth by inducing the expression of ALK. Reviewed

Lu F, Kishida S, Mu P, Huang P, Cao D, Tsubota S, Kadomatsu K.

Cancer Sci.   Vol. 106 ( 4 ) page： 390-396   2015.4

Atelocollagen-Mediated Intravenous siRNA Delivery Specific to Tumor Tissues Orthotopically Xenografted in Prostates of Nude Mice and Its Anticancer Effects. Reviewed

Yuan Y, Makita N, Cao D, Mihara K, Kadomatsu K, Takei Y.

Nucleic Acid Ther.   Vol. 25 ( 2 ) page： 85-94   2015.4

The nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation. Reviewed

Nakaguro M, Kiyonari S, Kishida S, Cao D, Murakami-Tonami Y, Ichikawa H, Takeuchi I, Nakamura S, Kadomatsu K.

Cancer Sci.   Vol. 106 ( 3 ) page： 237-243   2015.3

Neuroblastoma models for insights into tumorigenesis and new therapies. Reviewed

Kiyonari S, Kadomatsu K.

Expert Opin. Drug Discov.   Vol. 10 ( 1 ) page： 53-62   2015.1

CD147/basigin reflects renal dysfunction in patients with acute kidney injury. Reviewed

Nagaya H, Kosugi T, Maeda-Hori M, Maeda K, Sato Y, Kojima H, Hayashi H, Kato N, Ishimoto T, Sato W, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.

Clin. Exp. Nephrol.   Vol. 18 ( 5 ) page： 746-754   2014.10

Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation. Reviewed

Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, Sugimura K, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Miura M, Shimizu T, Ikeda S, Yaoita N, Fukumoto Y, Minami T, Miyata S, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.

Circ. Res.   Vol. 115 ( 8 ) page： 738-750   2014.9

Mechanisms of axon regeneration and its inhibition: roles of sulfated glycans. Reviewed

Kadomatsu K, Sakamoto K.

Arch. Biochem. Biophys.   Vol. 558   page： 36-41   2014.9

Keratan sulfate expression is associated with activation of a subpopulation of microglia/macrophages in Wallerian degeneration. Reviewed

Shinjo R, Imagama S, Ito Z, Ando K, Nishida Y, Ishiguro N, Kadomatsu K.

Neurosci. Lett.   Vol. 579   page： 80-85   2014.9

An EMMPRIN-γ-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions. Reviewed

Moreno V, Gonzalo P, Gómez-Escudero J, Pollán Á, Acín-Pérez R, Breckenridge M, Yáñez-Mó M, Barreiro O, Orsenigo F, Kadomatsu K, Chen CS, Enríquez JA, Dejana E, Sánchez-Madrid F, Arroyo AG.

J. Cell Sci.   Vol. 127   page： 3768-3781   2014.9

Chondroitin 6-O-sulfate ameliorates experimental autoimmune encephalomyelitis. Reviewed

Miyamoto K, Tanaka N, Moriguchi K, Ueno R, Kadomatsu K, Kitagawa H, Kusunoki S.

Glycobiology   Vol. 24 ( 5 ) page： 469-475   2014.5

Plasma CD147 reflects histological features in patients with lupus nephritis. Reviewed

Maeda-Hori M, Kosugi T, Kojima H, Sato W, Inaba S, Maeda K, Nagaya H, Sato Y, Ishimoto T, Ozaki T, Tsuboi N, Muro Y, Yuzawa Y, Imai E, Johnson R, Matsuo S, Kadomatsu K, Maruyama S.

Lupus   Vol. 23 ( 4 ) page： 342-352   2014.4

Therapeutic potential of midkine in cardiovascular disease. Reviewed

Kadomatsu K, Bencsik P, Görbe A, Csonka C, Sakamoto K, Kishida S, Ferdinandy P.

Br. J. Pharmacol.   Vol. 171 ( 4 ) page： 936-944   2014.2

Midkine: an emerging target of drug development for treatment of multiple diseases. Reviewed

Muramatsu T, Kadomatsu K.

Br. J. Pharmacol.   Vol. 171 ( 4 ) page： 811-813   2014.2

KSGal6ST Is Essential for the 6-Sulfation of Galactose within Keratan Sulfate in Early Postnatal Brain. Reviewed

Hoshino H, Foyez T, Ohtake-Niimi S, Takeda-Uchimura Y, Michikawa M, Kadomatsu K, Uchimura K.

J. Histochem. Cytochem.   Vol. 62 ( 2 ) page： 145-156   2014.2

Involvement of midkine in neuroblastoma tumourigenesis. Reviewed

Kishida S, Kadomatsu K.

Br. J. Pharmacol.   Vol. 171 ( 4 ) page： 896-904   2014.2

A new tumorsphere culture condition restores potentials of self-renewal and metastasis of primary neuroblastoma in a mouse neuroblastoma model. Reviewed

Cao D, Kishida S, Huang P, Mu P, Tsubota S, Mizuno M, Kadomatsu K.

PLoS One   Vol. 9 ( 1 ) page： e86813   2014.1

Sulfated glycans in network rewiring and plasticity after neuronal injuries. Reviewed

Kadomatsu K, Sakamoto K.

Neurosci. Res.   Vol. 78   page： 50-54   2014.1

Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Reviewed

Murakami-Tonami Y, Kishida S, Takeuchi I, Katou Y, Maris JM, Ichikawa H, Kondo Y, Sekido Y, Shirahige K, Murakami H, Kadomatsu K.

Cell Cycle   Vol. 13 ( 7 ) page： 1115-1131   2014

ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma. Reviewed

Hasan MK, Nafady A, Takatori A, Kishida S, Ohira M, Suenaga Y, Hossain S, Akter J, Ogura A, Nakamura Y, Kadomatsu K, Nakagawara A.

Sci. Rep.   Vol. 3   page： 3450   2013.12

Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis. Reviewed

Matsui H, Ohgomori T, Natori T, Miyamoto K, Kusunoki S, Sakamoto K, Ishiguro N, Imagama S, Kadomatsu K.

Cell Death Dis.   Vol. 4   page： e946   2013.12

Discovering combinatorial interactions in survival data. Reviewed

Duverle DA, Takeuchi I, Murakami-Tonami Y, Kadomatsu K, Tsuda K.

Bioinformatics   Vol. 29 ( 23 ) page： 3053-3059   2013.12

Expression of midkine in normal human skin, dermatitis and neoplasms: association with differentiation of keratinocytes. Reviewed

  Vol. 40 ( 12 ) page： 980-986   2013.12

Midkine overcomes neurite outgrowth inhibition of chondroitin sulfate proteoglycan without glial activation and promotes functional recovery after spinal cord injury.

Muramoto A, Imagama S, Natori T, Wakao N, Ando K, Tauchi R, Hirano K, Shinjo R, Matsumoto T, Ishiguro N, Kadomatsu K.

Neurosci. Lett.   Vol. 550   page： 150-155   2013.8

Ablation of keratan sulfate accelerates early phase pathogenesis of ALS. Reviewed

Hirano K, Ohgomori T, Kobayashi K, Tanaka F, Matsumoto T, Natori T, Matsuyama Y, Uchimura K, Sakamoto K, Takeuchi H, Hirakawa A, Suzumura A, Sobue G, Ishiguro N, Imagama S, Kadomatsu K.

PLoS One   Vol. 8 ( 6 ) page： e66969   2013.6

The heparin-binding growth factor midkine: the biological activities and candidate receptors.

Kadomatsu K, Kishida S, Tsubota S.

J. Biochem.   Vol. 153 ( 6 ) page： 511-521   2013.6

Minocycline selectively inhibits M1 polarization of microglia. Reviewed

Kobayashi K, Imagama S, Ohgomori T, Hirano K, Uchimura K, Sakamoto K, Hirakawa A, Takeuchi H, Suzumura A, Ishiguro N, Kadomatsu K.

Cell Death Dis.   Vol. 4   page： e525   2013.3

Midkine promotes neuroblastoma through Notch2 signaling. Reviewed

Kishida S, Mu P, Miyakawa S, Fujiwara M, Abe T, Sakamoto K, Onishi A, Nakamura Y, Kadomatsu K.

Cancer Res.   Vol. 73 ( 4 ) page： 1318-1327   2013.2

Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis.

Kojima H, Kosugi T, Sato W, Sato Y, Maeda K, Kato N, Kato K, Inaba S, Ishimoto T, Tsuboi N, Matsuo S, Maruyama S, Yuzawa Y, Kadomatsu K.

Am. J. Pathol.   Vol. 182 ( 2 ) page： 410-419   2013.2

Midkine in the pathology of cancer, neural disease, and inflammation. Reviewed

Sakamoto K, Kadomatsu K.

Pathol. Int.   Vol. 62 ( 7 ) page： 445-455   2012.7

CD44 expression in astrocytes and microglia is associated with ALS progression in a mouse model. Reviewed

Matsumoto T, Imagama S, Hirano K, Ohgomori T, Natori T, Kobayashi K, Muramoto A, Ishiguro N, Kadomatsu K.

Neurosci. Lett.   Vol. 520 ( 1 ) page： 115-120   2012.6

ADAMTS-13 is produced by glial cells and upregulated after spinal cord injury. Reviewed

Tauchi R, Imagama S, Ohgomori T, Natori T, Shinjo R, Ishiguro N, Kadomatsu K.

Neurosci. Lett.   Vol. 517 ( 1 ) page： 1-6   2012.5

The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury. Reviewed

Tauchi R, Imagama S, Natori T, Ohgomori T, Muramoto A, Shinjo R, Matsuyama Y, Ishiguro N, Kadomatsu K.

J. Neuroinflammation   Vol. 9   page： 53   2012.3

Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells. Reviewed

Sonobe Y, Li H, Jin S, Kishida S, Kadomatsu K, Takeuchi H, Mizuno T, Suzumura A.

J. Immunol.   Vol. 188 ( 6 ) page： 2602-2611   2012.3

Establishment and optimal culture conditions of microrna-induced pluripotent stem cells generated from HEK293 cells via transfection of microrna-302s expression vector. Reviewed

Koide N, Yasuda K, Kadomatsu K, Takei Y.

Nagoya J. Med. Sci.   Vol. 74 ( 1-2 ) page： 157-165   2012.2

Atelocollagen-mediated systemic delivery prevents immunostimulatory adverse effects of siRNA in mammals. Reviewed

Inaba S, Nagahara S, Makita N, Tarumi Y, Ishimoto T, Matsuo S, Kadomatsu K, Takei Y.

Mol. Ther.   Vol. 20 ( 2 ) page： 356-366   2012.2

Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms. Reviewed

Sakai K, Yamamoto A, Matsubara K, Nakamura S, Naruse M, Yamagata M, Sakamoto K, Tauchi R, Wakao N, Imagama S, Hibi H, Kadomatsu K, Ishiguro N, Ueda M.

J. Clin. Invest.   Vol. 122 ( 1 ) page： 80-90   2012.1

Keratan sulfate restricts neural plasticity after spinal cord injury. Reviewed

Imagama S, Sakamoto K, Tauchi R, Shinjo R, Ohgomori T, Ito Z, Zhang H, Nishida Y, Asami N, Takeshita S, Sugiura N, Watanabe H, Yamashita T, Ishiguro N, Matsuyama Y, Kadomatsu K.

J. Neurosci.   Vol. 31 ( 47 ) page： 17091-17102   2011.11

EMMPRIN modulates epithelial barrier function through a MMP-mediated occludin cleavage: implications in dry eye disease. Reviewed

Huet E, Vallée B, Delbé J, Mourah S, Prulière-Escabasse V, Tremouilleres M, Kadomatsu K, Doan S, Baudouin C, Menashi S, Gabison EE.

Am. J. Pathol.   Vol. 179 ( 3 ) page： 1278-1286   2011.9

A single intracoronary injection of midkine reduces ischemia/reperfusion injury in Swine hearts: a novel therapeutic approach for acute coronary syndrome. Reviewed

Ishiguro H, Horiba M, Takenaka H, Sumida A, Opthof T, Ishiguro YS, Kadomatsu K, Murohara T, Kodama I.

Front. Physiol.   Vol. 2   page： 27   2011.6

Keratan sulfate and related murine glycosylation can suppress murine cartilage damage in vitro and in vivo. Reviewed

Hayashi M, Kadomatsu K, Kojima T, Ishiguro N.

Biochem. Biophys. Res. Commun.   Vol. 409 ( 4 ) page： 732-737   2011.6

Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin. Reviewed

Kato K, Kosugi T, Sato W, Arata-Kawai H, Ozaki T, Tsuboi N, Ito I, Tawada H, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.

Clin. Exp. Nephrol.   Vol. 15 ( 3 ) page： 346-354   2011.6

The Neuronal Differentiation Factor NeuroD1 Downregulates Slit2 Expression and Promotes Cell Motility and Tumor Formation of Neuroblastoma. Reviewed

Huang P, Kishida S, Cao D, Murakami-Tonami Y, Mu P, Nakaguro M, Koide N, Takeuchi I, Onishi A, Kadomatsu K.

Cancer Res.   Vol. 71 ( 8 ) page： 2938-2948   2011.4

Premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1. Reviewed

Sakamoto K, Bu G, Chen S, Takei Y, Hibi K, Kodera Y, McCormick LM, Nakao A, Noda M, Muramatsu T, Kadomatsu K.

J. Biol. Chem.   Vol. 286 ( 10 ) page： 8405-8413   2011.3

[Proteoglycans and neural circuit reconstruction] Reviewed

Kadomatsu K.

Seikagaku   Vol. 83 ( 3 ) page： 240-246   2011.3

Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. Reviewed

Kato N, Kosugi T, Sato W, Ishimoto T, Kojima H, Sato Y, Sakamoto K, Maruyama S, Yuzawa Y, Matsuo S, Kadomatsu K.

Am. J. Pathol.   Vol. 178 ( 2 ) page： 572-579   2011.2

Hyaluronan oligosaccharides promote functional recovery after spinal cord injury in rats. Reviewed

Wakao N, Imagama S, Zhang H, Tauchi R, Muramoto A, Natori T, Takeshita S, Ishiguro N, Matsuyama Y, Kadomatsu K.

Neurosci. Lett.   Vol. 488 ( 3 ) page： 299-304   2011.1

Keratan sulfate in neuronal network reconstruction. Reviewed

Sakamoto K, Kadomatsu K.

Trends Glycosci. Glycotechnol.   Vol. 23   page： 212-220   2011

Keratan sulfate suppresses cartilage damage and ameliorates inflammation in an experimental mice arthritis model. Reviewed

Hayashi M, Kadomatsu K, Ishiguro N.

Biochem. Biophys. Res. Commun.   Vol. 401 ( 3 ) page： 463-468   2010.10

N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury. Reviewed

Ito Z, Sakamoto K, Imagama S, Matsuyama Y, Zhang H, Hirano K, Ando K, Yamashita T, Ishiguro N, Kadomatsu K.

J. Neurosci.   Vol. 30 ( 17 ) page： 5937-5947   2010.4

DRR1 is expressed in the developing nervous system and downregulated during neuroblastoma carcinogenesis. Reviewed

Asano Y, Kishida S, Mu P, Sakamoto K, Murohara T, Kadomatsu K.

Biochem. Biophys. Res. Commun.   Vol. 394 ( 3 ) page： 829-835   2010.4

Midkine gene transfer after myocardial infarction in rats prevents remodelling and ameliorates cardiac dysfunction. Reviewed

Sumida A, Horiba M, Ishiguro H, Takenaka H, Ueda N, Ooboshi H, Opthof T, Kadomatsu K, Kodama I.

Cardiovasc Res.   Vol. 86 ( 1 ) page： 113-121   2010.4

Midkine regulation of the renin-angiotensin system. Reviewed

Kadomatsu K.

Curr. Hypertens. Rep.   Vol. 12 ( 2 ) page： 74-79   2010.4

Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation. Reviewed

Miwa Y, Yamamoto K, Onishi A, Iwamoto M, Yazaki S, Haneda M, Iwasaki K, Liu D, Ogawa H, Nagasaka T, Uchida K, Nakao A, Kadomatsu K, Kobayashi T.

Xenotransplantation   Vol. 17 ( 1 ) page： 26-37   2010.2

Systemic delivery of siRNA specific to tumor mediated by atelocollagen: Combined therapy using siRNA targeting Bcl-xL and cisplatin against prostate cancer. Reviewed

Mu, P., Nagahara, S., Makita, N., Tarumi, Y., Kadomatsu, K., Takei, Y.

Int. J. Cancer   Vol. 125 ( 12 ) page： 2978-2990   2009.12

Successful cross-breeding of cloned pigs expressing endo-beta-galactosidase C and human decay accelerating factor. Reviewed

Yazaki S, Iwamoto M, Onishi A, Miwa Y, Suzuki S, Fuchimoto D, Sembon S, Furusawa T, Hashimoto M, Oishi T, Liu D, Nagasaka T, Kuzuya T, Maruyama S, Ogawa H, Kadomatsu K, Uchida K, Nakao A, Kobayashi T.

Xenotransplantation   Vol. 16 ( 6 ) page： 511-521   2009.11

Disruption of the midkine gene (Mdk) delays degeneration and regeneration in injured peripheral nerve. Reviewed

Sakakima H, Yoshida Y, Yamazaki Y, Matsuda F, Ikutomo M, Ijiri K, Muramatsu H, Muramatsu T, Kadomatsu K.

J. Neurosci. Res.   Vol. 87 ( 13 ) page： 2908-2915   2009.10

The E-selectin ligand Basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. Reviewed

Kato, N., Yuzawa, Y., Kosugi, T., Hobo, A., Sato, W., Miwa, Y., Sakamoto, K., Matsuo, S., Kadomatsu, K.

J. Am. Soc. Nephrol.   Vol. 20 ( 7 ) page： 1565-1576   2009.7

The growth factor midkine regulates the renin-angiotensin system in mice. Reviewed

Hobo, A., Yuzawa, Y., Kosugi, T., Kato, N., Asai, N., Sato, W., Maruyama, S., Ito, Y., Kobori, H., Ikematsu, S., Akira Nishiyama, A., Matsuo, S., Kadomatsu, K.

J. Clin. Invest.   Vol. 119 ( 6 ) page： 1616-1625   2009.6

Transforming growth factor-β1 upregulates keratan sulfate and chondroitin sulfate biosynthesis in microglias after brain injury. Reviewed

Yin, J., Sakamoto, K., Zhang, H., Ito, Z., Imagama, S., Kishida, S., Natori, T., Sawada, M., Matsuyama, Y., Kadomatsu, K.

Brain Res.   Vol. 1263   page： 10-22   2009.3

Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction. Reviewed

Takenaka, H., Horiba, M., Ishiguro, H., Sumida, A., Hojo, M., Usui, A., Akita, T., Sakuma, S., Ueda, Y., Kodama, I., Kadomatsu, K.

Am. J. Physiol. Heart Circ. Physiol.   Vol. 296 ( 2 ) page： 462-469   2009.2

Removal of blood group A/B antigen in organs by ex vivo and in vivo administration of ando-β-galactosidase (ABase) for ABO incompatible transplantation. Reviewed

Kobayashi, T., Liu, D., Ogawa, H., Miwa, Y., Nagasaka, T., Maruyama. S., Li, Y., Onishi, A., Iwamoto, M., Kuzuya, T., Kadomatsu, K., Uchida, K., Nakao, A.

Transplant Immunol.   Vol. 20 ( 3 ) page： 132-138   2009.1

Basal and stimulated lactate fluxes in primary cultures of astrocytes are differentially controlled by distinct proteins. Reviewed

Maekawa, F., Minehira, K., Kadomatsu, K., Pellerin, L.

J. Neurochem.   Vol. 107 ( 3 ) page： 789-798   2008.11

Plasma midkine leveliIs a prognostic factor for human neuroblastoma. Reviewed

Ikematsu, S., Nakagawara, A., Nakamura, Y., Ohira, M., Shinjo, M., Satoshi Kishida, S., Kadomatsu, K.

Cancer Sci.   Vol. 99 ( 10 ) page： 2070-2074   2008.10

Expression and roles of a xenopus head-forming gene homologue in human cancer cell lines. Reviewed

Zhu, Y., Tsuchida, A., Yamamoto, A., Furukawa, K., Tajima, O., Tokuda, N., Aizawa, S., Urano, T., Kadomatsu, K, Furukawa, K.

Nagoya J. Med. Sci.   Vol. 70 ( 3-4 ) page： 73-82   2008.8

Midkine is expressed by infiltrating macrophages in in-stent restenosis in hypercholesterolemic rabbits. Reviewed

Narita, H., Chen, S., Komori, K., Kadomatsu, K.

J. Vas. Surg.   Vol. 47 ( 6 ) page： 1322-1329   2008.6

Midkine and its clinical significance in endometrial carcinoma. Reviewed

Tanabe, K., Matsumoto, M., Ikematsu, S., Nagase, S., Hatakeyama, A., Takano, T., Niikura, H., Ito, K., Kadomatsu, K., Hayashi, S., Yaegashi, N.

Cancer Sci.   Vol. 99 ( 6 ) page： 1125-1130   2008.6

Downregulation of monocyte chemoattractant protein-1 involving short interfering RNA attenuates Hapten-induced contact hypersensitivity. Reviewed

Ishimoto, T., Takei, Y. Yuzawa, Y., Hanai, K., Nagahara, S., Tarumi, Y., Matsuo, S., Kadomatsu, K.

Mol. Ther.   Vol. 16 ( 2 ) page： 387-395   2008.2

In vivo silencing of a molecular target by short interfering RNA electroporation: Tumor vascularization correlates to delivery efficiency. Reviewed

Takei, Y., Nemoto, T., Mu, P., Fujishima, T., Ishimoto, T., Hayakawa, Y., Yuzawa, Y., Matsuo, S., Muramatsu, T., Kadomatsu, K.

Mol. Cancer Ther.   Vol. 7 ( 1 ) page： 211-221   2008.1

Midkine and LDL receptor-related protein 1 contribute to the anchorage -independent cell growth of cancer cells. Reviewed

Chen, S., Bu, G., Takei, Y., Sakamoto, K., Ikematsu, S., Muramatsu, T., Kadomatsu, K.

J.Cell Sci.   Vol. 120 ( Pt22 ) page： 4009-4015   2007.11

Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. Reviewed

Ishiguro K, Ando T, Maeda O, Ohmiya N, Niwa Y, Kadomatsu K, Goto H.

Biochem. Biophys. Res. Commun.   Vol. 362 ( 1 ) page： 218-223   2007.10

Midkine is involved in tubulo-interstitial inflammation associated with diabetic nephropathy. Reviewed

Kosugi, T., Yuzawa, Y., Sato, W., Kato, N., Arata-Kawai, H., Matsuo, S., Kadomatsu. K.

Lab. Invest.   Vol. 87 ( 9 ) page： 903-913   2007.9

Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia. Reviewed

Hidaka, H., Yagasaki, H. Takahashi, Y., Hama, A., Nishio, N., Tanaka, M, Yoshida, N., Villalobos, I.B., Wang, Y., Xu. Y.Y., Horibe, K., Chen, S., Kadomatsu, K., Kojima, S.

Leukemia Res.   Vol. 31 ( 8 ) page： 1045-1051   2007.8

Midkine as a novel target for antibody therapy in osteosarcoma. Reviewed

Maehara H, Kaname T, Yanagi K, Hanzawa H, Owan I, Kinjou T, Kadomatsu K, Ikematsu S, Iwamasa T, Kanaya F, Naritomi K.

Biochem. Biophys. Res. Commun.   Vol. 358 ( 3 ) page： 757-762   2007.7

Alternative Strategy for Overcoming ABO Incompatibility. Reviewed

Kobayashi T, Liu D, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Li YT, Onishi A, Kuzuya T, Kadomatsu K, Uchida K, Nakao A.

Transplantation   Vol. 83 ( 9 ) page： 1284-1286   2007.5

Relation between human decay-accelerating factor (hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity: value of highly expressed hDAF for Xenotransplantation. Reviewed

Liu, D., Kobayashi, T., Onishi, A., Furusawa, T., Iwamoto, M., Suzuki, S., Miwa, Y., Nagasaka, T., Maruyama, S., Kadomatsu, K., Uchida, K., Nakao, A.

Xenotransplantation   Vol. 14 ( 1 ) page： 67-73   2007.1

Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation. Reviewed

Ishiguro K, Ando T, Maeda O, Hasegawa M, Kadomatsu K, Ohmiya N, Niwa Y, Xavier R, Goto H.

Toxicol. Appl. Pharmacol.   Vol. 217 ( 1 ) page： 35-42   2006.11

Brain keratan sulfate and glial scar formation. Reviewed

Zhang, H., Uchimura, K., Kadomatsu, K.

Ann. NY Acad. Sci.   Vol. 1086   page： 81-90   2006.11

Midkine plays a protective role against cardiac ischemia /reperfusion Injury through a reduction of apoptotic reaction. Reviewed

Horiba M, Kadomatsu K, Uasui K, Lee J, Takenaka H, Sumida A, Kamiya K, Chen S, Sakuma S, Muramatsu T, Komada I.

Circulation   Vol. 114 ( 16 ) page： 1713-1720   2006.10

Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts. Reviewed

Banno H, Takei Y, Muramatsu T, Komori K, Kadomatsu K.

J. Vas. Surg.   Vol. 44 ( 3 ) page： 633-641   2006.9

Combinational antitumor effect of siRNA against midkine and paclitaxel on growth of human prostate cancer xenografts. Reviewed

Takei Y, Kadomatsu K, Goto T, Muramatsu T.

Cancer   Vol. 107 ( 4 ) page： 864-873   2006.8

N-Acetylglucosamine 6-O-sulfotransferase-1 is required for brain keratan sulfate biosynthesis and glial scar formation after brain injury. Reviewed

Zhang H, Muramatsu T, Murase A, Yuasa S, Uchimura K, Kadomatsu K.

Glycobiology   Vol. 16 ( 8 ) page： 702-710   2006.8

Loss of core fucosylation of low-density lipoprotein receptor-related protein-1 impairs its function, leading to the upregulation of serum levels of insulin-like growth factor-binding protein 3 in Fut8-/- mice. Reviewed

Lee SH, Takahashi M, Honke K, Miyoshi E, Osumi D, Sakiyama H, Ekuni A, Wang X, Inoue S, Gu J, Kadomatsu K, Taniguchi N.

J. Biochem.   Vol. 139 ( 3 ) page： 391-398   2006.3

Growth factor midkine is involved in the pathogenesis of diabetic nephropathy. Reviewed

Kosugi T, Yuzawa Y, Sato W, Kawai H, Matsuo S, Takei Y, Muramatsu T, Kadomatsu K.

Am. J. Pathol.   Vol. 168 ( 1 ) page： 9-19   2006.1

Putative midkine family protein up-regulation in Patella caerulea (Mollusca, Gastropoda) exposed to sublethal concentrations of cadmium. Reviewed

Vanucci S, Minerdi D, Kadomatsu K, Mengoni A, Bazzicalupo M.

Aquat. Toxicol.   Vol. 75 ( 4 ) page： 374-379   2005.11

N-Acetylglucosamine-6-O-sulfotransferase-1 and -2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules. Reviewed

Kawashima, H., Petryniak, B., Hiraoka, N., Mitoma, J., Huckaby, V., Nakayama, J., Uchimura, K. Kadomatsu, K., Muramatsu, T., Lowe, J.B., Fukuda, M.

Nat. Immunol.   Vol. 6 ( 11 ) page： 1096-1104   2005.11

The midkine family in cancer, inflammation and neural development. Reviewed

Kadomatsu, K.

Nagoya J. Med. Sci.   Vol. 67 ( 3-4 ) page： 71-82   2005.6

Antisense oligodeoxyribonucleotide as to the growth factor midkine suppresses neointima formation induced by balloon Injury. Reviewed

Hayashi, K., Banno, H., Kadomatsu, K.*, Takei, Y., Komori, K., Muramatsu, T.

Am. J. Physiol. Heart Circ. Physiol.   Vol. 288 ( 5 ) page： 2203-2209   2005.5

Morpholino antisense oligomer targeting human midikine: its application for cancer therapy. Reviewed

Takei, Y., Kadomatsu, K., Yuasa, K., Sato, W., Muramatsu, T.

Int. J. Cancer   Vol. 114 ( 3 ) page： 490-497   2005.4

Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion. Reviewed

Sato, W., Takei, Y., Yuzawa,Y., Matsuo, S., Kadomatsu, K., Muramatsu, T.

Kidney Int.   Vol. 67 ( 4 ) page： 1330-1339   2005.4

Postischemic gene transfer of midkine, a neurotrophic factor, protects against focal brain ischemia. Reviewed

Takada, J., Ooboshi, H., Ago, T., Kitazono, T., Yao, H., Kadomatsu, K., Muramatsu, T., Ibayashi, S., Iida, M.

Gene Ther.   Vol. 12 ( 6 ) page： 487-493   2005.3

In vivo delivery technique of nucleic acid compounds using atelocollagen: its use in cancer therapeutics targeted at the heparin-binding growth factor midkine. Invited

Takei, Y., Kadomatsu, K.

Gene Ther. Mol. Biol.   Vol. 9   page： 257-264   2005

Midkine expression in rat spinal motor neurons following sciatic nerve injury. Reviewed

Sakakima, H., Yoshida, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S., Muramatsu, T.

Brain Res. Dev. Brain Res.   Vol. 153 ( 2 ) page： 251-260   2004.11

Effects of flanking genes on the phenotypes of mice deficient in basigin/CD147. Reviewed

Chen, S., Kadomatsu, K., Kondo, M., Toyama, Y., Toshimori, K., Ueno, S., Miyake, Y., Muramatsu, T.

Biochem. Biophys. Res. Commun.   Vol. 324 ( 1 ) page： 147-153   2004.11

Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage. Reviewed

Kawai, H., Sato, W., Yuzawa, Y., Kosugi, T., Matsuo, S., Takei, Y., Kadomatsu, K., Muramatsu, T.

Am. J. Pathol.   Vol. 165 ( 5 ) page： 1603-1612   2004.11

N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing. Reviewed

Uchimura, K., Kadomatsu, K., El-Fasakhany, F.M., Singer, M.S., Izawa, M., Kannagi, R., Takeda, N., Rosen, S.D., Muramatsu, T.

J. Biol. Chem.   Vol. 279 ( 33 ) page： 35001-35008   2004.8

Midkine promoter-driven suicide gene expression and -mediated adenovirus replication produced cytotoxic effects to immortalised and tumour cells. Reviewed

Yu, L., Hamada, K., Namba, M., Kadomatsu, K., Muramatsu, T., Matsubara, S., Tagawa, M.

Eur. J. Cancer   Vol. 40 ( 11 ) page： 1787-1794   2004.7

Basigin expression and regulation in mouse ovary during the sexual maturation and development of corpus luteum. Reviewed

Chang, H., Ni, H., Ma, X.H., Xu, L.B., Kadomatsu, K., Muramatsu, T., Yang, Z.M.

Mol. Reprod. Dev.   Vol. 68 ( 2 ) page： 135-141   2004.6

A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. Reviewed

Takei, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S, Muramatsu, T.

Cancer Res.   Vol. 64 ( 10 ) page： 3365-3370   2004.5

Proteasomal degradation of the nuclear targeting growth factor midkine. Reviewed

Suzuki, N., Shibata, Y., Urano, T., Murohara, T., Muramatsu, T., Kadomatsu, K.

J. Biol. Chem.   Vol. 279 ( 17 ) page： 17785-17791   2004.4

Expression of glucose transporter 4 (GLUT4) in the human pancreatic islet of Langerhans. Reviewed

Kobayashi, H., Mitsui, T., Nomura, S., Ohno, Y., Kadomatsu, K., Muramatsu, T., Nagasaka, T., Mizutani, S.

Biochem. Biophys. Res. Commun.   Vol. 314 ( 4 ) page： 1121-1125   2004.2

Midkine and pleiotrophin in neural development and cancer. Invited

Kadomatsu, K., Muramatsu, T.

Cancer Lett.   Vol. 204 ( 2 ) page： 127-143   2004.2

Insertion of an exogenous promoter in the E1A regulatory region of adenovirus does not disturb viral replication despite reduced E1A transcription. Reviewed

Yu, L., Hamada, K., Namba, M., Kadomatsu, K., Muramatsu, T., Matsubara, S., Tagawa, M.

Cancer Lett.   Vol. 203 ( 1 ) page： 51-57   2004.1

Tissue distribution of placental leucine aminopeptidase/oxytocinase during mouse pregnancy. Reviewed

Kobayashi, H., Nomura, S., Mitsui, T., Ito. T., Kuno, N., Ohno, Y., Kadomatsu, K., Muramatsu, T., Nagasaka, T., Mizutani, S.

J. Histochem. Cytochem.   Vol. 52 ( 1 ) page： 113-121   2004.1

Ovarian mature cystic teratoma with a highly differentiated homunculus: a case report. Reviewed

Kuno, N., Kadomatsu, K., Nakamura, M., Miwa-Fukuchi, T., Hirabayashi, N., Ishizuka, T.

Birth Defect. Res. Part A Clin. Mol. Teratol.   Vol. 70 ( 1 ) page： 40-46   2004.1

Midkine promoter can mediate transcriptional activation of a fused suicide gene in a broader range of human breast cancer compared with c-erbB-2 promoter. Reviewed

Yu, L., Yamamoto, N., Kadomatsu, K., Muramatsu, T., Matsubara, .S, Sakiyama, S., Tagawa, M.

Oncology   Vol. 66 ( 2 ) page： 143-149   2004

Expression of basigin, a member of the immunoglobulin superfamily, in the mouse cochlea. Reviewed

Kawano H, Tono T, Kadomatsu K, Muramatsu T, Komune S.

Otorhinolaryngol. Relat. Spec.   Vol. 65 ( 6 ) page： 327-331   2003.11

A promoter region of the midkine gene that is frequently expressed in human hepatocellular carcinoma can activate a suicide gene as effectively as the alpha-fetoprotein promoter. Reviewed

Tomizawa M, Yu L, Wada A, Tamaoki T, Kadomatsu K, Muramatsu T, Matsubara S, Watanabe K, Ebara M, Saisho H, Sakiyama S, Tagawa M.

Br. J. Cancer   Vol. 89 ( 6 ) page： 1086-1090   2003.9

Cell growth- and P53-dependent transcriptional activity of the midkine promoter confers suicide gene expression in tumor cells. Reviewed

Yu L, Ugai S, O-Wang J, Namba M, Kadomatsu K, Muramatsu T, Matsubara S, Sakiyama S, Tagawa M.

Oncol. Rep.   Vol. 10 ( 5 ) page： 1301-1305   2003.9

Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma. Reviewed

Shimada H, Nabeya Y, Tagawa M, Okazumi S, Matsubara H, Kadomatsu K, Muramatsu T, Ikematsu S, Sakuma S, Ochiai T.

Cancer Sci.   Vol. 94 ( 7 ) page： 628-632   2003.7

High levels of urinary midkine in various cancer patients. Reviewed

Ikematsu S, Okamoto K, Yoshida Y, Oda M, Sugano-Nagano H, Ashida K, Kumai H, Kadomatsu K, Muramatsu H, Takashi Muramatsu, Sakuma S.

Biochem. Biophys. Res. Commun.   Vol. 306 ( 2 ) page： 329-332   2003.6

Correlation of elevated level of blood midkine with poor prognostic factors of human neuroblastomas. Reviewed

Ikematsu S, Nakagawara A, Nakamura Y, Sakuma S, Wakai K, Muramatsu T, Kadomatsu K.

Br. J. Cancer   Vol. 88 ( 10 ) page： 1522-1526   2003.5

Increased basigin in bleomycin-induced lung injury. Reviewed

Betsuyaku T, Kadomatsu K, Griffin GL, Muramatsu T, Senior RM.

Am. J. Respir. Cell Mol. Biol.   Vol. 28 ( 5 ) page： 600-606   2003.5

Increased serum midkine concentration as a possible tumor marker in patients with superficial esophageal cancer. Reviewed

Shimada H, Nabeya Y, Okazumi S, Matsubara H, Kadomatsu K, Muramatsu T, Ikematsu S, Sakuma S, Ochiai T.

Oncol. Rep.   Vol. 10 ( 2 ) page： 411-414   2003.3

Utilization of the promoter region of the midkine gene as a tool to drive therapeutic genes in a tumor specific manner. Reviewed

Sakiyama S, Yu L, Tomizawa M, Shimada H, Kadomatsu K, Muramatsu T, Ikematsu S, Nakagawara A, Tagawa M.

Adv. Enzyme Regul.   Vol. 43   page： 57-66   2003

Nuclear targeting by the growth factor midkine. Reviewed

Shibata, Y., Muramatsu, T., Hirai, M., Inui, T., Kimura, T., Saito, H., Lynn M. McCormick, L.M., Bu, G., Kadomatsu, K.,

Mol. Cell Biol.   Vol. 22 ( 19 ) page： 6788-6796   2002.10

Basigin expression and hormonal regulation in mouse uterus during the peri-implantation period. Reviewed

Xiao LJ, Chang H, Ding NZ, Ni H, Kadomatsu K, Yang ZM.

Mol. Reprod. Dev.   Vol. 63 ( 1 ) page： 47-54   2002.9

Basigin expression and hormonal regulation in the rat uterus during the peri-implantation period. Reviewed

Xiao LJ, Diao HL, Ma XH, Ding NZ, Kadomatsu K, Muramatsu T, Yang ZM.

Reproduction   Vol. 124 ( 2 ) page： 219-225   2002.8

Reduction of alpha-galactosyl xenoantigen by expression of endo-beta-galactosidase C in pig endothelial cells. Reviewed

Ogawa H, Kobayashi T, Yokoyama I, Nagatani N, Mizuno M, Yoshida J, Kadomatsu K, Muramatsu H, Nakao A, Muramatsu T.

Xenotransplantation   Vol. 9 ( 4 ) page： 290-296   2002.7

5'-,3'-inverted thymidine-modified antisense oligodeoxynucleotide targeting midkine. Its design and application for cancer therapy. Reviewed

Takei Y, Kadomatsu K, Itoh H, Sato W, Nakazawa K, Kubota S, Muramatsu T.

J. Biol. Chem.   Vol. 277 ( 6 ) page： 23800-23806   2002.6

Enzymatic removal of alphaGal antigen in pig kidneys by ex vivo and in vivo administration of endo-beta-galactosidase C. Reviewed

Liu D, Kobayashi T, Yokoyama I, Ogawa H, Nagasaka T, Muramatsu H, Kadomatsu K, Oikawa T, Shimano Y, Morozumi K, Uchida K, Muramatsu T, Nakao A.

Xenotransplantation   Vol. 9 ( 3 ) page： 228-236   2002.5

Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice. Reviewed

Yanada M, Kojima T, Ishiguro K, Nakayama Y, Yamamoto K, Matsushita T, Kadomatsu K, Nishimura M, Muramatsu T, Saito H.

Blood   Vol. 99 ( 7 ) page： 2455-2458   2002.4

Midkine expression is associated with postnatal development of the lungs. Reviewed

Matsuura O, Kadomatsu K, Takei Y, Uchimura K, Mimura S, Watanabe K, Muramatsu T.

Cell Struct. Funct.   Vol. 27 ( 2 ) page： 109-115   2002.4

Behaviour of a sperm surface transmembrane glycoprotein basigin during epididymal maturation and its role in fertilization in mice. Reviewed

Saxena DK, Oh-Oka T, Kadomatsu K, Muramatsu T, Toshimori K.

Reproduction   Vol. 123 ( 3 ) page： 435-444   2002.3

Functional analysis of the chondroitin 6-sulfotransferase gene in relation to lymphocyte subpopulations, brain development and oversulfated chondroitin sulfates. Reviewed

Uchimura, K., Kadomatsu, K., Nishimura, H., Muramatsu, H., Nakamura, E., Kurosawa, N., Habuchi, O., El-Fasakhany, F.M., Yoshikai, Y., Muramatsu, T.

J. Biol. Chem.   Vol. 277 ( 2 ) page： 1443-1450   2002.1

A promoter region of midkine gene can activate transcription of an exogenous suicide gene in human pancreatic cancer. Reviewed

Yoshida Y, Tomizawa M, Bahar R, Miyauchi M, Yamaguchi T, Saisho H, Kadomatsu K, Muramatsu T, Matsubara S, Sakiyama S, Tagawa M.

Anticancer Res.   Vol. 22 ( 1A ) page： 117-120   2002.1

Midkine expression in the course of nephrogenesis and its role in ischaemic reperfusion injury. Reviewed

Sato W, Yuzawa Y, Kadomatsu K, Tayasu T, Muramatsu H, Muramatsu T, Matsuo S.

Nephrol. Dial. Transplant.   Vol. 9   page： 52-54   2002

Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice. Reviewed

Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Iwase M, Yoshikai Y, Yanada M, Yamamoto K, Matsushita T, Nishimura M, Kusugami K, Saito H, Muramatsu T.

J. Biol. Chem.   Vol. 276 ( 50 ) page： 47483-47488   2001.12

Antisense oligodeoxynucleotide targeted to Midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells. Reviewed

Takei Y, Kadomatsu K, Matsuo S, Itoh H, Nakazawa K, Kubota S, Muramatsu T.

Cancer Res.   Vol. 61 ( 23 ) page： 8486-8491   2001.12

Expression of midkine in the cochlea. Reviewed

Jia XQ, Nakashima T, Kadomatsu K, Muramatsu T.

Hearing Res.   Vol. 160 ( 1-2 ) page： 10-14   2001.10

Midkine is involved in neutrophil infiltration into the tubulointerstitium in ischemic renal injury. Reviewed

Sato W, Kadomatsu K, Yuzawa Y, Muramatsu H, Hotta N, Matsuo S, Muramatsu T.

J. Immunol.   Vol. 167 ( 6 ) page： 3463-3469   2001.9

Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth. Reviewed

Kurosawa N, Chen GY, Kadomatsu K, Ikematsu S, Sakuma S, Muramatsu T.

Glycoconj. J.   Vol. 18 ( 6 ) page： 499-507.   2001.6

Haptotactic migration induced by midkine: Involvement of protein-tyrosine phosphatase z, mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Reviewed

Qi, M., Ikematsu, S., Maeda, N., Ichihara-Tanaka, K., Sakuma, S., Noda, M., Muramatsu, T., Kadomatsu, K.

J. Biol. Chem.   Vol. 276 ( 19 ) page： 15868-15875   2001.5

Requirement of chondroitin sulfate/dermatan sulfate recognition in midkine-dependent migration of macrophages. Reviewed

Hayashi K, Kadomatsu K, Muramatsu T.

Glycoconj. J.   Vol. 18 ( 5 ) page： 401-406   2001.5

Syndecan-4 deficiency increases susceptibility to kappa-carrageenan-induced renal damage. Reviewed

Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Matsuo S, Kusugami K, Saito H, Muramatsu T.

Lab. Invest.   Vol. 81 ( 4 ) page： 509-516   2001.4

Retinal degeneration following failed photoreceptor maturation in 5A11/basigin null mice. Reviewed

Ochrietor JD, Moroz TM, Kadomatsu K, Muramatsu T, Linser PJ.

Exp. Eye Res.   Vol. 72 ( 4 ) page： 467-477   2001.4

Expression of herpes simplex virus-thymidine kinase gene controlled by a promoter region of the midkine gene confers selective cytotoxicity to ganciclovir in human carcinoma cells. Reviewed

Miyauchi M, Yoshida Y, Tada Y, Narita M, Maeda T, Bahar R, Kadomatsu K, Muramatsu T, Matsubara S, Nakagawara A, Sakiyama S, Tagawa M.

Int. J. Cancer   Vol. 91 ( 5 ) page： 723-727   2001.3

Antisense oligonucleotide targeted to midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells. Reviewed

Takei, Y., Kadomatsu, K., Matsuo, S., Itoh, H., Nakazawa, K., Kubota, S., Muramatsu, T.,

Cancer Res.   Vol. 61   page： 8486-8491   2001

Syndecan-4 deficiency impairs the fetal vessels in the placental labyrinth. Reviewed

Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Nakamura E, Ito M, Nagasaka T, Kobayashi H, Kusugami K, Saito H, Muramatsu T.

Dev. Dyn.   Vol. 219 ( 4 ) page： 539-544   2000.12

Midkine inhibits bradykinin-stimulated Ca(2+) signaling and nitric oxide production in endothelial cells. Reviewed

Tran QK, Watanabe H, Le HY, Yang J, Takeuchi K, Kadomatsu K, Muramatsu T, Ohashi K.

Biochem. Biophys. Res. Commun.   Vol. 276 ( 3 ) page： 830-836   2000.10

Complete antithrombin deficiency in mice results in embryonic lethality. Reviewed

Ishiguro K, Kojima T, Kadomatsu K, Nakayama Y, Takagi A, Suzuki M, Takeda N, Ito M, Yamamoto K, Matsushita T, Kusugami K, Muramatsu T, Saito H.

J. Clin. Invest.   Vol. 106 ( 7 ) page： 873-878   2000.10

Overexpression of midkine in pancreatic duct adenocarcinomas induced by N-Nitrosobis(2-oxopropyl)amine in hamsters and their cell lines. Reviewed

Tsutsumi M, Kadomatsu K, Tsujiuchi T, Sakitani H, Ikematsu S, Kubozoe T, Yoshimoto M, Muramatsu T, Sakuma S, Konishi Y.

Jpn. J. Cancer Res.   Vol. 91 ( 10 ) page： 979-986   2000.10

Serum midkine levels are increased in patients with various types of carcinomas. Reviewed

Ikematsu S, Yano A, Aridome K, Kikuchi M, Kumai H, Nagano H, Okamoto K, Oda M, Sakuma S, Aikou T, Muramatsu H, Kadomatsu K, Muramatsu T.

Br. J. Cancer   Vol. 83 ( 6 ) page： 701-706   2000.9

Retinal dysfunction in basigin deficiency. Reviewed

Hori K, Katayama N, Kachi S, Kondo M, Kadomatsu K, Usukura J, Muramatsu T, Mori S, Miyake Y.

Invest. Ophthalmol. Vis. Sci.   Vol. 41 ( 10 ) page： 3128-3133   2000.9

Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities. Reviewed

Uchimura K, Fasakhany F, Kadomatsu K, Matsukawa T, Yamakawa T, Kurosawa N, Muramatsu T.

Biochem. Biophys. Res. Commun.   Vol. 274 ( 2 ) page： 291-296   2000.8

Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain. Reviewed

Yoshida S, Shibata M, Yamamoto S, Hagihara M, Asai N, Takahashi M, Mizutani S, Muramatsu T, Kadomatsu K.

Eur. J. Biochem.   Vol. 267 ( 14 ) page： 4372-4380   2000.7

Distinct expression of midkine and pleiotrophin in the spinal cord and placental tissues during early mouse development. Reviewed

Fan QW, Muramatsu T, Kadomatsu K.

Dev. Growth Differ.   Vol. 42 ( 2 ) page： 113-119   2000.4

Midkine expression in Reed-Sternberg cells of Hodgkin's disease. Reviewed

Kato H, Watanabe K, Murari M, Isogai C, Kinoshita T, Nagai H, Ohashi H, Nagasaka T, Kadomatsu K, Muramatsu H, Muramatsu T, Saito H, Mori N, Murate T.

Leuk. Lymphoma   Vol. 37 ( 3-4 ) page： 415-424   2000.4

Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions. Reviewed

Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Tsuzuki S, Nakamura E, Kusugami K, Saito H, Muramatsu T.

J. Biol. Chem.   Vol. 275 ( 8 ) page： 5249-5252   2000.2

Neointima formation in a restenosis model is suppressed in midkine-deficient mice. Reviewed

Horiba, M., Kadomatsu, K., Nakamura, E., Muramatsu, H., Ikematsu, S., Sakuma, S., Hayashi, K., Yuzawa, Y., Matsuo, S., Kuzuya, M., Kaname, T., Hirai, M., Siato, H., Muramatsu, T.

J. Clin. Invest   Vol. 105 ( 4 ) page： 489-495   2000.2

Midkine rescues Wilms' tumor cells from cisplatin-induced apoptosis: regulation of Bcl-2 expression by Midkine. Reviewed

Qi M, Ikematsu S, Ichihara-Tanaka K, Sakuma S, Muramatsu T, Kadomatsu K.

J. Biochem.   Vol. 127 ( 2 ) page： 269-277   2000.2

Polyadenylation signal facilitates the expression of foreign gene that is driven by an internal promoter located in the reverse orientation to long terminal repeat of retrovirus. Reviewed

Narita M, Takanaga K, Yoshida Y, Kadomatsu K, Muramatsu T, Matsubara S, Hamada H, Goto S, Saisho H, Sakiyama S, Tagawa M.

Anticancer Res.   Vol. 20 ( 1A ) page： 279-282   2000.1

Midkine binds specifically to sulfatide the role of sulfatide in cell attachment to midkine-coated surfaces. Reviewed

Kurosawa N, Kadomatsu K, Ikematsu S, Sakuma S, Kimura T, Muramatsu T.

Eu. J. Biochem.   Vol. 267 ( 2 ) page： 344-351   2000.1

Genomic organization and promoter activity of embigin, a member of the immunoglobulin superfamily. Reviewed

Tachikui H, Kurosawa N, Kadomatsu K, Muramatsu T.

Gene   Vol. 240 ( 2 ) page： 325-332   1999.11

Expression of the midkine gene in human hepatocellular carcinomas. Reviewed

Koide N, Hada H, Shinji T, Ujike K, Hirasaki S, Yumoto Y, Hanafusa T, Kadomatsu K, Muramatsu H, Muramatsu T, Tsuji T.

Hepato-Gastroenterol.   Vol. 46 ( 30 ) page： 3189-3196   1999.11

Immunohistochemical analysis of midkine expression in human prostate carcinoma. Reviewed

Konishi N, Nakamura M, Nakaoka S, Hiasa Y, Cho M, Uemura H, Hirao Y, Muramatsu T, Kadomatsu K.

Oncology   Vol. 57 ( 3 ) page： 253-257   1999.10

Spatially and temporally regulated expression of N-acetylglucosamine-6-O-sulfotransferase during mouse embryogenesis. Reviewed

Fan QW, Uchimura K, Yuzawa Y, Matsuo S, Mitsuoka C, Kannagi R, Muramatsu H, Kadomatsu K, Muramatsu T.

Glycobiology   Vol. 9 ( 9 ) page： 947-955   1999.9

Determination of the optimal time and dosage of all-trans retinoic acid for induction of murine exencephaly. Reviewed

Kuno N, Kadomatsu K, Muramatsu T.

Teratology   Vol. 60 ( 2 ) page： 63-67   1999.8

Syndecan-4 expression is associated with follicular atresia in mouse ovary. Reviewed

Ishiguro K, Kojima T, Taguchi O, Saito H, Muramatsu T, Kadomatsu K.

Histochem. Cell Biol.   Vol. 112 ( 1 ) page： 25-33   1999.7

Histological characterization of defective spermatogenesis in mice lacking the basigin gene. Reviewed

Toyama Y, Maekawa M, Kadomatsu K, Miyauchi T, Muramatsu T, Yuasa S.

Anat. Histol. Embryol.   Vol. 28 ( 3 ) page： 205-213   1999.7

A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta. Reviewed

Maeda N, Ichihara-Tanaka K, Kimura T, Kadomatsu K, Muramatsu T, Noda M.

J. Biol. Chem.   Vol. 274 ( 18 ) page： 12474-12479   1999.4

Frequent expression of midkine gene in esophageal cancer suggests a potential usage of its promoter for suicide gene therapy. Reviewed

Miyauchi M, Shimada H, Kadomatsu K, Muramatsu T, Matsubara S, Ikematsu S, Takenaga K, Asano T, Ochiai T, Sakiyama S, Tagawa M.

Jpn. J. Cancer Res.   Vol. 90 ( 4 ) page： 469-475   1999.4

Overexpression of midkine in lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats and its increase with progression. Reviewed

Sakitani H, Tsutsumi M, Kadomatsu K, Ikematsu S, Takahama M, Iki K, Tsujiuchi T, Muramatsu T, Sakuma S, Sakaki T, Konishi Y.

Carcinogenesis   Vol. 20 ( 3 ) page： 465-469   1999.3

Levels of expression of pleiotrophin and protein tyrosine phosphatase zeta are decreased in human colorectal cancers. Reviewed

Yamakawa T, Kurosawa N, Kadomatsu K, Matsui T, Itoh K, Maeda N, Noda M, Muramatsu T.

Cancer Lett.   Vol. 135 ( 1 ) page： 91-96   1999.1

Expression of midkine in the early stage of carcinogenesis in human colorectal cancer. Reviewed

Ye C, Qi M, Fan QW, Ito K, Akiyama S, Kasai Y, Matsuyama M, Muramatsu T, Kadomatsu K.

Br. J. Cancer   Vol. 79 ( 1 ) page： 179-184   1999.1

Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour. Reviewed

Nakamura E, Kadomatsu K, Yuasa S, Muramatsu H, Mamiya T, Nabeshima T, Fan QW, Ishiguro K, Igakura T, Matsubara S, Kaname T, Horiba M, Saito H, Muramatsu T.

Genes Cells   Vol. 3 ( 12 ) page： 811-822   1998.12

Stage-specific localization of basigin, a member of the immunoglobulin superfamily, during mouse spermatogenesis. Reviewed

Maekawa M, Suzuki-Toyota F, Toyama Y, Kadomatsu K, Hagihara M, Kuno N, Muramatsu T, Dohmae K, Yuasa S.

Arch. Histol. Cytol.   Vol. 61 ( 5 ) page： 405-415   1998.12

Human N-acetylglucosamine-6-O-sulfotransferase involved in the biosynthesis of 6-sulfo sialyl Lewis X: molecular cloning, chromosomal mapping, and expression in various organs and tumor cells. Reviewed

Uchimura K, Muramatsu H, Kaname T, Ogawa H, Yamakawa T, Fan QW, Mitsuoka C, Kannagi R, Habuchi O, Yokoyama I, Yamamura K, Ozaki T, Nakagawara A, Kadomatsu K, Muramatsu T.

J. Biochem.   Vol. 124 ( 3 ) page： 670-678   1998.9

Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase. Reviewed

Uchimura K, Muramatsu H, Kadomatsu K, Fan QW, Kurosawa N, Mitsuoka C, Kannagi R, Habuchi O, Muramatsu T.

J. Biol. Chem.   Vol. 273 ( 35 ) page： 22577-22583   1998.8

Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas. Reviewed

Aridome K, Takao S, Kaname T, Kadomatsu K, Natsugoe S, Kijima F, Aikou T, Muramatsu T.

Br. J. Cancer   Vol. 78 ( 4 ) page： 472-477   1998.8

Clusters of basic amino acids in midkine: roles in neurite-promoting activity and plasminogen activator-enhancing activity. Reviewed

Akhter S, Ichihara-Tanaka K, Kojima S, Muramatsu H, Inui T, Kimura T, Kaneda N, Talukder AH, Kadomatsu K, Inagaki F, Muramatsu T.

J. Biochem.   Vol. 123 ( 6 ) page： 1127-1136   1998.6

Embigin/basigin subgroup of the immunoglobulin superfamily: different modes of expression during mouse embryogenesis and correlated expression with carbohydrate antigenic markers. Reviewed

Fan QW, Kadomatsu K, Uchimura K, Muramatsu T.

Dev. Growth Differ.   Vol. 40 ( 3 ) page： 277-286   1998.6

Porcine alpha-1,3-galactosyltransferase: full length cDNA cloning, genomic organization, and analysis of splicing variants. Reviewed

Katayama A, Ogawa H, Kadomatsu K, Kurosawa N, Kobayashi T, Kaneda N, Uchimura K, Yokoyama I, Muramatsu T, Takagi H.

Glycoconjugate J.   Vol. 15 ( 6 ) page： 583-589   1998.6

Mouse chondroitin 6-sulfotransferase: molecular cloning, characterization and chromosomal mapping. Reviewed

Uchimura K, Kadomatsu K, Fan QW, Muramatsu H, Kurosawa N, Kaname T, Yamamura K, Fukuta M, Habuchi O, Muramatsu T.

Glycobiology   Vol. 8 ( 5 ) page： 489-496   1998.5

Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Reviewed

Kuno N, Kadomatsu K, Fan QW, Hagihara M, Senda T, Mizutani S, Muramatsu T.

FEBS Lett.   Vol. 425 ( 2 ) page： 191-194   1998.3

A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis. Reviewed

Igakura, T., Kadomatsu, K., Kaname, T., Muramatsu, H., Fan, Q.-W., Miyauchi, T., Toyama, Y., Kuno, N., Yuasa, S., Takahashi, M., Senda, M., Taguchi, O., Yamamura, K., Arimura, K., Muramatsu, T.,

Dev. Biol.   Vol. 194 ( 2 ) page： 152-165   1998.2

Functional modules and expression of mouse p40(phox) and p67(phox), SH3-domain-containing proteins involved in the phagocyte NADPH oxidase complex. Reviewed

Mizuki K, Kadomatsu K, Hata K, Ito T, Fan QW, Kage Y, Fukumaki Y, Sakaki Y, Takeshige K, Sumimoto H.

Eur. J. Biochem.   Vol. 251 ( 3 ) page： 573-582   1998.2

Midkine counteracts the activin signal in mesoderm induction and promotes neural formation. Reviewed

Yokota C, Takahashi S, Eisaki A, Asashima M, Akhter S, Muramatsu T, Kadomatsu K.

J. Biochem.   Vol. 123 ( 2 ) page： 339-346   1998.2

Midkine expression in transient retinal ischemia in the rat. Reviewed

Miyashiro M, Kadomatsu K, Ogata N, Yamamoto C, Takahashi K, Uyama M, Muramatsu H, Muramatsu T.

Curr. Eye Res.   Vol. 17 ( 1 ) page： 9-13   1998.1

Expression of basigin, a member of the immunoglobulin superfamily, in the mouse central nervous system. Reviewed

Fan QW, Yuasa S, Kuno N, Senda T, Kobayashi M, Muramatsu T, Kadomatsu K.

Neurosci. Res.   Vol. 30 ( 1 ) page： 53-63   1998.1

Increased expression of midkine during the progression of human astrocytomas. Reviewed

Mishima K, Asai A, Kadomatsu K, Ino Y, Nomura K, Narita Y, Muramatsu T, Kirino T.

Neurosci. Lett.   Vol. 233 ( 1 ) page： 29-32   1997.9

Expression of midkine and pleiotropin in ovarian tumors. Reviewed

Nakanishi T, Kadomatsu K, Okamoto T, Tomoda Y, Muramatsu T.

Obstet. Gynecol.   Vol. 90 ( 2 ) page： 285-290   1997.8

Abnormalities of sensory and memory functions in mice lacking Bsg gene. Reviewed

Naruhashi K, Kadomatsu K, Igakura T, Fan QW, Kuno N, Muramatsu H, Miyauchi T, Hasegawa T, Itoh A, Muramatsu T, Nabeshima T.

Biochem. Biophys. Res. Commun.   Vol. 236 ( 3 ) page： 733-737   1997.7

Expression of the retinoid-inducible polypeptide, midkine, in human epidermal keratinocytes. Reviewed

Inazumi T, Tajima S, Nishikawa T, Kadomatsu K, Muramatsu H, Muramatsu T.

Arch. Dermatol. Res.   Vol. 289 ( 8 ) page： 471–475   1997.7

Dimerization of midkine by tissue transglutaminase and its functional implication. Reviewed

Kojima S, Inui T, Muramatsu H, Suzuki Y, Kadomatsu K, Yoshizawa M, Hirose S, Kimura T, Sakakibara S, Muramatsu T.

J. Biol. Chem.   Vol. 272 ( 14 ) page： 9410-9416   1997.4

Direct gene replacement of the mouse Alpha(1,3)-galactosyltransferase gene with human Alpha(1,2)-fucosyltransferase gene: converting Alpha-galactosyl epitopes into H antigens. Reviewed

Chihiro Koike, Akio Katayama, Kenji Kadomatsu, Takashi Muramatsu, Nozomu Hiraiwa, Reiji Kannagi, Izumi Nakashima, Itsuo Yokoyama, Hiroshi Takagi.

Xenotransplantation   Vol. 4   page： 147-153   1997.4

Le(X) structure enhances myocardial differentiation from embryonic stem cells. Reviewed

Sudou A, Muramatsu H, Kaname T, Kadomatsu K, Muramatsu T.

Cell Struct. Funct.   Vol. 22 ( 2 ) page： 247-251   1997.4

alpha-Galactosyl oligosaccharides conjugated with polyethylene glycol as potential inhibitors of hyperacute rejection upon xenotransplantation. Reviewed

Nagasaka T, Kobayashi T, Muramatsu H, Fujimoto H, Matsuo I, Ajisaka K, Kadomatsu K, Hayashi S, Yokoyama I, Hayakawa A, Muramatsu T, Takagi H.

Biochem. Biophys. Res. Commun.   Vol. 232 ( 3 ) page： 731-736   1997.3

Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine. Reviewed

Nakanishi T, Kadomatsu K, Okamoto T, Ichihara-Tanaka K, Kojima T, Saito H, Tomoda Y, Muramatsu T.

J. Biochem.   Vol. 121 ( 2 ) page： 197-205   1997.2

Alteration of midkine expression associated with chemically-induced differentiation in human neuroblastoma cells. Reviewed

Koshizawa SH, Matsumura T, Kadono Y, Sawada T, Kadomatsu K, Muramatsu H, Muramatsu T.

Cancer Lett.   Vol. 111 ( 1-2 ) page： 117-125   1997.1

Midkine induces the transformation of NIH3T3 cells. Reviewed

Kadomatsu K, Hagihara M, Akhter S, Fan QW, Muramatsu H, Muramatsu T.

Br. J. Cancer   Vol. 75 ( 3 ) page： 354-359   1997

Regulation of apoptosis induced by TGF-b1 in non-tumorigenic and tumorigenic rat prostatic epithelial cell lines. Reviewed

Kadomatsu, K., Hsing, A.Y., Bonham, M.J., Danielpour, D.

Cancer Res.   Vol. 56 ( 22 ) page： 5146-5149   1996.11

Regulation of apoptosis induced by transforming growth factor-beta1 in nontumorigenic rat prostatic epithelial cell lines. Reviewed

Hsing AY, Kadomatsu K, Bonham MJ, Danielpour D.

Cancer Res.   Vol. 56 ( 22 ) page： 5146-5149   1996.11

Roles of basigin, a member of the immunoglobulin superfamily, in behavior as to an irritating odor, lymphocyte response, and blood-brain barrier. Reviewed

Igakura T, Kadomatsu K, Taguchi O, Muramatsu H, Kaname T, Miyauchi T, Yamamura K, Arimura K, Muramatsu T.

Biochem. Biophys. Res. Commun.   Vol. 224 ( 1 ) page： 33-36   1996.7

Enzyme-linked immunoassay for midkine, and its application to evaluation of midkine levels in developing mouse brain and sera from patients with hepatocellular carcinomas. Reviewed

Muramatsu H, Song XJ, Koide N, Hada H, Tsuji T, Kadomatsu K, Inui T, Kimura T, Sakakibara S, Muramatsu T.

J. Biochem.   Vol. 119 ( 6 ) page： 1171-1175   1996.6

The expression of truncated MK in human tumors. Reviewed

Kaname T, Kadomatsu K, Aridome K, Yamashita S, Sakamoto K, Ogawa M, Muramatsu T, Yamamura K.

Biochem. Biophys. Res. Commun.   Vol. 219 ( 1 ) page： 256-260   1996.2

Intoroduction of Alpha(1,2) fucosyltransferase and its effect on Alpha-Gal epitopes in transgenic pig. Reviewed

Chihiro Koike, Reiji Kannagi, Yoshihiro Takuma, Fumiko Akutsu, Satoshi Hayashi, Nozomu Hiraiwa, Kenji Kadomatsu, Takashi Muramatsu, Hirohito Yamakawa, Takuya Nagai, Shoji Kobayashi, Hidechika Okada, Izumi Nakashima, Kazuharu Uchida, Itsuo Yokoyama, Hiroshi Takagi.

Xenotransplantation   Vol. 3   page： 81-86   1996

Increased midkine gene expression in human gastrointestinal cancers. Reviewed

Aridome, K., Tsutsui, J., Takao, S., Kadomatsu, K., Ozawa, M., Aikou, T., Muramatsu, T.

Jpn. J. Cancer Res.   Vol. 86 ( 7 ) page： 655-661   1995.7

Restricted expression of Xenopus midkine gene during early development. Reviewed

Sekiguchi K, Yokota C, Asashima M, Kaname T, Fan QW, Muramatsu T, Kadomatsu K.

J. Biochem.   Vol. 118 ( 1 ) page： 94-100   1995.7

Development and characterization of nontumorigenic and tumorigenic epithelial cell lines from rat dorsal-lateral prostate. Reviewed

Danielpour, D., Kadomatsu, K., Anzano, M.A., Smith, J.M., Sporn, M.B.

Cancer Res.   Vol. 54 ( 13 ) page： 3413-3421   1994.7

Histogenesis of induced prostate carcinoma in Lobund-Wistar rats : A model system for histologic scoring and grading. Reviewed

Slayter, M.V., Anzano, M.A., Kadomatsu, K., Sporn, M.B., Smith, J.

Cancer Res.   Vol. 54 ( 6 ) page： 1440-1445   1994.3

Expression of sulfated glycoprotein 2 is associated with carcinogenesis induced by N-nitroso-N-methylurea in rat prostate and seminal vesicle. Reviewed

Kadomatsu, K., Anzano, M.A., Slayter, M.V., Winokur, T.S., Smith, J.M., Sporn, M.B.

Cancer Res.   Vol. 53 ( 7 ) page： 1480-1483   1993.4

A new family of heparin-binding growth differentiation factors : Increased midkine expression in Wilms' tumor and other human carcinomas. Reviewed

Tsutsui, J., Kadomatsu, K., Matsubara, S., Nakagawara, A., Hamanoue, M., Takao, S., Shimazu, H., Ohi, Y., Muramatsu, T.

Cancer Res.   Vol. 53 ( 6 ) page： 1281-1285   1993.3

Embigin, a member of the immunoglobulin superfamily expressed in embryonic cells, enhances cell-substratum adhesion. Reviewed

Huang, R.-P., Ozawa, M., Kadomatsu, K. Muramatsu, T.

Dev. Biol.   Vol. 155 ( 2 ) page： 307-314   1993.2

Genomic structure of human midkine (MK), a retinoic acid-responsive growth/differentiation factor. Reviewed

Uehara, K., Matsubara, S., Kadomatsu, K., Tsutsui, J., Muramatsu, T.

J. Biochem.   Vol. 111 ( 5 ) page： 563-567   1992.5

Undifferentiated (embryonal) sarcoma of the liver : Report of three cases.

Kadomatsu, K., Nakagawara, A., Zaizen, Y., Nagoshi, M., Tsuneyoshi, M., Fukushige, T., Haigo, A., Suita, S.

Surg.Today   Vol. 22 ( 5 ) page： 451-455   1992

A new family of heparin-binding factors : Strong conservation of midkine (MK) sequences between the human and the mouse. Reviewed

Tsutsui, J., Uehara, K., Kadomatsu, K., Matsubara, S., Muramatsu, T.

Biochem. Biophys. Res. Commun.   Vol. 176 ( 2 ) page： 792-797   1991.4

Inverse expression of MYCN and MDR-1 in human neuroblastoma. Reviewed

Nakagawara, A., Kadomatsu, K., Sato, S., Kohno, K., Takano, H., Kuwano, M.

Prog. Clin. Biol. Res.   Vol. 366   page： 11-19   1991

Developmentally regulated expression of embigin, a member of the immunoglobulin superfamily found in embryonal carcinoma cells. Reviewed

Huang, R-P., Ozawa, M., Kadomatsu, K., Muramatsu, T.

Differentiation   Vol. 45 ( 2 ) page： 76-83   1990.11

A retinoic acid responsive gene, MK, produces a secreted protein with heparin binding activity. Reviewed

Tomomura, M., Kadomatsu, K., Nakamoto, M., Muramatsu, H., Kondoh, H., Imagawa, K., Muramatsu, T.

Biochem. Biophys. Res. Commun.   Vol. 171 ( 2 ) page： 603-609   1990.9

A retinoic acid responsive gene, MK, found in the teratocarcinoma system : Heterogeneity of the transcript and the nature of the translation product. Reviewed

Tomomura, M., Kadomatsu, K., Matsubara, S., Muramatsu, T.

J. Biol. Chem.   Vol. 265 ( 18 ) page： 10765-10770   1990.6

Structure of a retinoic acid-responsive gene, MK, which is transiently activated during the differentiation of embryonal carcinoma cells and the mid-gestation period of mouse embryogenesis. Reviewed

Matsubara, S., Tomomura, M., Kadomatsu, K., Muramatsu, T.

J. Biol. Chem.   Vol. 265 ( 16 ) page： 9441-9443   1990.6

Inverse correlation between expression of multidrug resistance gene and N-myc oncogene in human neuroblastomas. Reviewed

Nakagawara, A., Kadomatsu, K., Sato, S., Kohno, K., Takano, H., Akazawa, K., Nose, Y., Kuwano, M.

Cancer Res.   Vol. 50 ( 10 ) page： 3043-3047   1990.5

*A retinoic acid responsive gene, MK, found in the teratocarcinoma system is expressed in spatially and temporally controlled manner during mouse embyogenesis. Reviewed

Kadomatsu, K., Huang, R-P., Suganuma, T., Murata, F., Muramatsu, T.,

J. Cell Biol.   Vol. 110 ( 3 ) page： 607-616   1990.3

Cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Reviewed

Kadomatsu, K., Tomomura, M., Muramatsu, T.

Biochem. Biophys. Res. Commun.   Vol. 151 ( 3 ) page： 1312-1318   1988.3

Sugar Chains. The Involvement of Midkine, a Heparin-Binding Growth Factor, in Cancer Development.

Kishida S and Kadomatsu K.（ Role： Sole author）

Springer   2015 

Glycoscience: Biology and Medicine. Glycosaminoglycans: Key Regulator for Recovery from Neuronal Injuries.

門松健治（ Role： Sole author）

2015 

最先端メディカルエンジニアリング・成長因子ミッドカインの作用機構　

門松健治（ Role： Joint author）

一粒書房  2013.3 

Midkine: From Embryogenesis to Pathogenesis and Therapy. Midkine and heart failure.

Horiba M, Kadomatsu K.（ Role： Sole author）

Springer   2012 

Midkine: From Embryogenesis to Pathogenesis and Therapy. The potential of MK through the renin-angiotensin system.

Kosugi T, Kadomatsu K.（ Role： Sole author）

Springer   2012 

Midkine: From Embryogenesis to Pathogenesis and Therapy. Role of midkine in nephrogenesis and kidney disease.

Sato W, Kadomatsu K.（ Role： Sole author）

Springer   2012 

Midkine: From Embryogenesis to Pathogenesis and Therapy. Midkine and chemoresistance in cancers.

Takei Y, Kadomatsu K.（ Role： Sole author）

Springer   2012 

Midkine: From Embryogenesis to Pathogenesis and Therapy. Vascular restenosis and midkine.

Kadomatsu K.（ Role： Sole author）

Springer   2012 

Experimental Glycoscience. The Midkine Family and Its Receptors.

Kadomatsu, K.（ Role： Sole author）

Springer   2008 

Neural Proteoglycans. Keratan sulfate and gliosis.

Kadomatsu, K.（ Role： Sole author）

Research Signpost  2007 

糖鎖科学の新展開　機能解明・次世代型材料・医薬品開発に向けて・ミッドカインファミリー　

門松健治（ Role： Sole author）

2005 

心臓ナビゲーター・ミッドカイン　

門松健治、林健司（ Role： Sole author）

メディカルレビュー社  2004 

医学大辞典・ビタミンAその他　

門松健治（ Role： Sole author）

医学書院  2003 

Vascular Biology ナビゲーター・ミッドカイン　

門松健治（ Role： Sole author）

メディカルレビュー社  2001 

月刊がん9月「研究最前線」・がん研究レポート　ミッドカインはヒトのガン組織で大量に産生される

門松健治（ Role： Sole author）

日本医療情報出版　  2000 

月刊がん10月「研究最前線」・がん研究レポート　腫瘍マーカー、分子標的としての脚光を浴びるミッドカイン

門松健治（ Role： Sole author）

日本医療情報出版  2000 

わかりやすい分子生物学・核受容体とステロイドホルモンの作用機構　

門松健治（ Role： Sole author）

丸善株式会社  1999 

ティシュエンジニアリング-組織工学の基礎と応用・クローン技術と異種臓器移植　

小林孝彰、小川晴子、長坂隆治、林衆治、横山逸男、中尾昭公、佐藤英明、三好和睦、門松健治、村松喬、高木弘（ Role： Joint author）

名古屋大学出版会  1999 

わかりやすい分子生物学・細胞の死　

門松健治（ Role： Sole author）

丸善株式会社  1999 

BioScience用語ライブラリー・MidkineとPleiotrophin　

門松健治（ Role： Sole author）

羊土社  1998 

細胞工学:グライコバイオロジー実験プロトコール・ミッドカイン-cDNA導入による細胞機能の改変-　

門松健治（ Role： Sole author）

秀潤社  1996 

Proteoglycans and neural plasticity. Invited

Kadomatsu K.

Glycosaminoglycans in axon regeneration and neural plasticity. Invited International conference

Kadomatsu K.

Glycans in Neural Plasticity. Invited International conference

Kadomatsu K.

2017 Glyco-retreat 

Sulfated glycans regulate autophagy and axon regenetation. Invited International conference

Kadomatsu K.

SfN-Neuroscience2016 

Mechanisms of axon regeneration inhibition after neuronal injury. Invited International conference

Kadomatsu K.

Freiburg/Adelaide/Nagoya Annual Symposium 

Mechanisms of Axon Regeneration and its Inhibition. Invited International conference

Kadomatsu K.

Fourth Midkine Symposium 

Sulfated glycans regulate autophagy and axon regeneration. Invited International conference

Kadomatsu K.

The 3rd International symposium on Glyco-neuroscience 

Sulfated glycans regulates autophagy and axon regenetration. Invited International conference

Why should we care about glycans in the brain. Invited International conference

Kadomatsu K.

Society for Glycobiology : Satellite Symposium II Glycans in Neuroscience 

Role of Keratan sulfate and chondroitin sulfate in axon regeneration. Invited International conference

Kadomatsu K.

4th ECMNET Conference 

Biomedical research at Nagoya University. Invited International conference

Kadomatsu K.

International joint symposium Nagoya University, University of Adelaide, University of Freiburg 

Roles of sulfated glycans and autophagy in dystrophic endball formation in the axonal regeneration inhibition. International conference

Kadomatsu K.

International symposium on Glyco-neuroscience 

Keratan sulfate and neuronal circuit reconstruction. International conference

Kadomatsu K.

Proteoglycans 2013 

A link between two sugar chains, keratan sulfate and chondroitin sulfate, in axonal regeneration/sprouting. International conference

Kadomatsu K.

GCOE International Symposium 

Regulation of neural Neuroscienceplasticity by sugar chains-towards integration of glyco- and neuro-biology. International conference

Kadomatsu K.

Neuroscience2012 

Midkine: at the intersection of neurobiology and cancer. International conference

Kadomatsu K.

Excellence in midkine research conference(Key Note Lecture) 

Neuronal differentiation factor and neuroblastoma development. International conference

Kadomatsu K.

International Symposium on Developmental Biology and Cancer 

Proteoglycans and neuronal network reconstruction. International conference

Kadomatsu K.

7th international conference on proteoglycans 

Proteoglycans and neuronal network reconstruction. International conference

Kadomatsu K.

Glycobiology Japan-Netherland joint seminar 

Keratan sulfate biosynthesis is required for glial scar formation after brain injury. International conference

The 21st century COE program 3rd international symposium 

N-Acetylglucosamine 6-O-sulfotransferase mice show loss of keratin sulfate in the brain. International conference

2nd Workshop the Netherlands-Japan Recent Advances in Glycobiology, Utrecht 

N-acetylglucosamine-6-O-sulfotransferase-1 deficiency causes loss of keratan sulfate in the developing brain and injured brain. International conference

Glycobiology 14, 1065, 2004. Joint meeting of the Society for glycobiology and the Japanese society of carbohydrate research 

Nuclear targeting by the growth factor midkine. International conference

9th World congress on advances in oncology and 7th International symposium on molecular medicine 

神経発達および精神機能における成長因子ミッドカインの役割

門松健治

Neuro2004（第27回日本神経科学大会、第47回日本神経化学会大会合同大会） 

沖縄県北部産島野菜の免疫調節機能及び抗腫瘍機能を活用した健康食品及び医薬品の開発・事業化

2015.4 - 2017.3

受託研究 

VRK1キナーゼ阻害剤による難治性神経芽腫の治療法開発（先端）

2015.4 - 2017.3

学内共同研究 

難治性神経芽種の合成致死治療（先端）

2013.4 - 2016.3

学内共同研究 

神経芽腫治療法開発へのモデル動物の応用

2013.4 - 2015.3

受託研究 

癌に対するミッドカインRNAアプタマーの研究

2007.4 - 2017.3

国内共同研究 

疾患モデルブタの研究開発

2007.4 - 2012.3

特色ある大学教育支援プログラム 

生物学基礎I

2019

生物の化学

2019

人体機能学

2019

生物学基礎Ⅰ

2018

生物の化学

2018

人体機能学

2018

生物学基礎Ⅰ

2017

生物の化学

2017

人体機能学

2017

生物学基礎Ⅰ

2016

生物の化学

2016

基礎セミナーＡ

2016

人体機能学

2016

生物学基礎Ⅰ

2015

生物の化学

2015

基礎セミナーＡ

2015

生物学基礎Ⅰ

2014

生物の化学

2014

基礎セミナーＡ

2014

生物学基礎Ⅰ

2013

生物の化学

2013

基礎セミナーＡ

2013

生物の化学

2012

基礎セミナーＡ

2012

生物学基礎Ⅰ

2012

生物学基礎Ⅰ

2011

基礎セミナーＡ

2011

Bichemistry

2011