Institute for Glyco-core Research Professor
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Updated on 2024/04/04
医学博士 (九州大学医研 第830号) ( 1989.11 九州大学 )
chondroitin sulfate
keratan sulfate
sulfotransferase
chondroitin 6-O sulfotransferase
N-acetylglucosamin 6-O sulfotransferase
EMMPRIN
CD147
baisigin
growth factor
midkine
Others / Others / Neurobiology
Others / Others / Glycobiology
Life Science / Medical biochemistry / Biochemistry
硫酸化糖鎖による神経回路再編制御機構解明
神経芽腫研究
Basiginの体内における役割
硫酸化糖鎖による腎疾患・自己免疫性疾患に対するアプローチ硫酸化糖鎖による腎疾患・自己免疫性疾患に対するアプローチ
ExosomesとmicroRNA
糖鎖生命コア研究所 所長(センター長)
2021.1
Nagoya University Dean
2017.4
Country:Japan
Nagoya University Director in General
2015.7 - 2017.3
Country:Japan
Nagoya University
2012.4 - 2017.3
Country:Japan
名古屋大学総長補佐 (研究推進担当)
2012.4 - 2017.3
Country:Japan
Nagoya University
2012.4 - 2015.3
Nagoya University Graduate School of Medicine
2012.4 - 2015.3
Nagoya University
2012.3 - 2017.4
Country:Japan
Nagoya University Graduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering Director in General
2012.3 - 2015.3
名古屋大学総長補佐(創薬科学担当)
2009.4 - 2012.3
Country:Japan
Department of Biochemistry Nagoya University Graduate School of Medicine. Professor
2004.9
Country:Japan
名古屋大学大学院医学系研究科 助教授
2002.4
Country:Japan
名古屋大学大学院医学研究科 助教授(生物化学講座分子生物学:名称変更)
2000.4
Country:Japan
名古屋大学医学部 助教授 (第一生化学)
1996.8
Country:Japan
名古屋大学医学部 講師 (第一生化学)
1994.5
Country:Japan
名古屋大学医学部 助手 (第一生化学)
1993.10
Country:Japan
アメリカ国立衛生研究所客員研究員
1990.10
Country:Japan
鹿児島大学医学部 助手 (第二生化学)
1990.4
Country:Japan
九州大学医学部附属病院医員 (小児外科)
1989.4
Country:Japan
鹿児島大学医学部 助手 (第二生化学)
1988.4
Country:Japan
九州大学医学部附属病院医員 (小児外科、周産期)
1982.11
Country:Japan
福岡市立こども病院医員 (小児外科)
1982.5
Country:Japan
Kyushu University Graduate School, Division of Medicine
1984.4 - 1988.3
Country: Japan
Kyushu University Faculty of Medicine
1976.4 - 1982.3
Country: Japan
日本生化学会 理事
2019.11 - 2021.11
日本糖質学会 会長
2019.7 - 2021.6
日本癌学会 評議員
2018.1
日本糖質学会 理事
2017.7 - 2019.6
Advances in Neuroblastoma Research Association (ANRA) Asia/Australia/Africa representative
2016.4 - 2018.3
JCGG
Clinical Professor (honorary) (honorary)
2018.2 - 2020.6
Journal of Biochemistry Editor in Chief
2018.1
自然科学研究機構生理学研究所運営会議委員 運営委員
2018
自然科学研究機構生命創成探究センター運営委員 運営委員
2018
Canser Science Associate Editor
2015
日本学術会議連携委員 連携会員
2012 - 2020.9
Flokert Belzer Award for distiguished research
2001
平成9年度 日本生化学会奨励賞
1997 日本生化学会
Enoxaparin promotes functional recovery after spinal cord injury by antagonizing PTPRσ Invited Reviewed
Ito S, Ozaki T, Morozumi M, Imagama S, Kadomatsu K, Sakamoto K.
Exp. Neurol. 2021
Continuing medical education during pandemic waves of COVID-19: Consensus from medical faculties in Asia, Australia and Europe. Invited Reviewed International coauthorship
Carmen Wong , Walter van den Broek, Gillian Doody, Martin Fischer, Michelle Leech , Fabrizio De Ponti , Alexander Gerbes, Hiroshi Nishigori, Young Mee Lee, Maarten Frens, Hideki Kasuya, Franco Bazzoli, Reinhard Hickel , Hong Sik Lee, J.P.T.M van Leeuwen, Christina Mitchell, Kenji Kadomatsu, John Atherton, Francis Chan.
MedEdPublish. AMEE Journal 2021.3
Combination of tumor necrosis factor-alpha and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells
Huang Yue, Tsubota Shoma, Nishio Nobuhiro, Takahashi Yoshiyuki, Kadomatsu Kenji
CANCER SCIENCE Vol. 112 ( 2 ) page: 715 - 724 2021.2
Chondroitin 6-sulfate represses keratinocyte proliferation in mouse skin, which is associated with psoriasis
Kitazawa Kazuyuki, Nadanaka Satomi, Kadomatsu Kenji, Kitagawa Hiroshi
COMMUNICATIONS BIOLOGY Vol. 4 ( 1 ) 2021.1
Systemic treatment with a novel basic fibroblast growth factor mimic small-molecule compound boosts functional recovery after spinal cord injury.
Imagama S, Ogino R, Ueno S, Murayama N, Takemoto N, Shimmyo Y, Kadoshima T, Tamura S, Kuroda M, Matsuyama Y, Kadomatsu K, Morita Y, Inoue T, Ishiguro N
PloS one Vol. 15 ( 7 ) page: e0236050 2020.7
Growth Factor Midkine Aggravates Pulmonary Arterial Hypertension via Surface Nucleolin
Kinoshita Daisuke, Shishido Tetsuro, Takahashi Tetsuya, Yokoyama Miyuki, Sugai Takayuki, Watanabe Ken, Tamura Harutoshi, Nishiyama Satoshi, Takahashi Hiroki, Arimoto Takanori, Miyamoto Takuya, Watanabe Tetsu, Kishida Satoshi, Kadomatsu Kenji, Abe Jun-ichi, Takeishi Yasuchika, Konta Tsuneo, Kubota Isao, Watanabe Masafumi
SCIENTIFIC REPORTS Vol. 10 ( 1 ) page: 10345 2020.6
Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage inMYCN-amplified neuroblastoma cells
Yamashita Ken, Kiyonari Shinichi, Tsubota Shoma, Kishida Satoshi, Sakai Ryuichi, Kadomatsu Kenji
CANCER SCIENCE Vol. 111 ( 7 ) page: 2431-2439 2020.6
Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase
Hayasaki Takahiro, Ishimoto Takuji, Doke Tomohito, Hirayama Akiyoshi, Soga Tomoyoshi, Furuhashi Kazuhiro, Kato Noritoshi, Kosugi Tomoki, Tsuboi Naotake, Lanaspa Miguel A., Johnson Richard J., Maruyama Shoichi, Kadomatsu Kenji
JOURNAL OF NUTRITIONAL BIOCHEMISTRY Vol. 71 page: 54-62 2019.9
CD147/Basigin Deficiency Prevents the Development of Podocyte Injury through FAK Signaling
Yoshioka Tomoki, Kosugi Tomoki, Masuda Tomohiro, Watanabe Tomoharu, Ryuge Akihiro, Nagaya Hiroshi, Maeda Kayaho, Sato Yuka, Katsuno Takayuki, Kato Noritoshi, Ishimoto Takuji, Yuzawa Yukio, Maruyama Shoichi, Kadomatsu Kenji
AMERICAN JOURNAL OF PATHOLOGY Vol. 189 ( 7 ) page: 1338-1350 2019.7
Glycan sulfation patterns define autophagy flux at axon tip via PTPR sigma-cortactin axis
Sakamoto Kazuma, Ozaki Tomoya, Ko Yen-Chun, Tsai Cheng-Fang, Gong Yuanhao, Morozumi Masayoshi, Ishikawa Yoshimoto, Uchimura Kenji, Nadanaka Satomi, Kitagawa Hiroshi, Zulueta Medel Manuel L., Bandaru Anandaraju, Tamura Jun-ichi, Hung Shang-Cheng, Kadomatsu Kenji
NATURE CHEMICAL BIOLOGY Vol. 15 ( 7 ) page: 699-+ 2019.7
Compositional analysis of the glycosaminoglycan family in velvet antlers of Sika deer (Cervus nippon) at different growing stages
Takeda-Okuda Naoko, Mizumoto Shuji, Zhang Zui, Kim Soo-Ki, Lee Chi-Ho, Jeon Byong-Tae, Hosaka Yoshinao Z., Kadomatsu Kenji, Yamada Shuhei, Tamura Jun-ichi
GLYCOCONJUGATE JOURNAL Vol. 36 ( 2 ) page: 127 - 139 2019.4
Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18
Nariai Yuko, Kamino Hiroki, Obayashi Eiji, Kato Hiroaki, Sakashita Gyosuke, Sugiura Tomoko, Migita Kiyoshi, Koga Tomohiro, Kawakami Atsushi, Sakamoto Kazuma, Kadomatsu Kenji, Nakakido Makoto, Tsumoto Kouhei, Urano Takeshi
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS Vol. 663 page: 71 - 82 2019.3
GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain
Narentuya, Takeda-Uchimura Yoshiko, Foyez Tahmina, Zhang Zui, Akama Tomoya O., Yagi Hirokazu, Kato Koichi, Komatsu Yukio, Kadomatsu Kenji, Uchimura Kenji
SCIENTIFIC REPORTS Vol. 9 ( 1 ) page: 4387 2019.3
miR-146a targeted to splenic macrophages prevents sepsis-induced multiple organ injury. Reviewed
Funahashi Y, Kato N, Masuda T, Nishio F, Kitai H, Ishimoto T, Kosugi T, Tsuboi N, Matsuda N, Maruyama S, Kadomatsu K.
Lab Invest. 2019.1
Compositional analysis of the glycosaminoglycan family in velvet antlers of Sika deer (Cervus nippon) at different growing stages. Reviewed
Takeda-Okuda N, Mizumoto S, Zhang Z, Kim SK, Lee CH, Jeon BT, Hosaka YZ, Kadomatsu K, Yamada S, Tamura JI.
Glycoconj J. 2019.1
Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18. Reviewed
Nariai Y, Kamino H, Obayashi E, Kato H, Sakashita G, Sugiura T, Migita K, Koga T, Kawakami A, Sakamoto K, Kadomatsu K, Nakakido M, Tsumoto K, Urano T.
Arch Biochem Biophys. Vol. 663 page: 71-82 2019.1
Technologies to Elucidate Functions of Glycans
Furukawa Koichi, Ohmi Yuhsuke, Kondo Yuji, Ohkawa Yuki, Tajima Orie, Furukawa Keiko, Honke Koichi, Inokuchi Jin-ichi, Gu Jianguo, Kadomatsu Kenji, Nadanaka Satomi, Kitagawa Hiroshi, Nishihara Shoko, Nomura Kazuya, Oka Shogo, Ito Makoto, Kitajima Ken, Natsuka Shunji, Kanagawa Motoi, Ishimizu Takeshi, Fujiyama Kazuhito, Chiba Yasunori, Osada Hiroyuki
GLYCOSCIENCE: BASIC SCIENCE TO APPLICATIONS: INSIGHTS FROM THE JAPAN CONSORTIUM FOR GLYCOBIOLOGY AND GLYCOTECHNOLOGY (JCGG) page: 87-124 2019
Glycans in Nervous System
Sato Chihiro, Gu Jianguo, Fukuda Tomohiko, Kadomatsu Kenji, Ikenaka Kazuhiro
GLYCOSCIENCE: BASIC SCIENCE TO APPLICATIONS: INSIGHTS FROM THE JAPAN CONSORTIUM FOR GLYCOBIOLOGY AND GLYCOTECHNOLOGY (JCGG) page: 209-219 2019
Single-cell transcriptomic analysis reveals the early separation of neuroblastoma fate in Th-MYCN mice
Tsubota Shoma, Kishida Satoshi, Kadomatsu Kenji
CANCER SCIENCE Vol. 109 page: 1112-1112 2018.12
Analysis of the genes which showed synthetic lethal phenotype with BAP1 mutations in malignant mesothelioma cells
Murakami-Tonami Yuko, Kiyonari Shinichi, Tabe Yoko, Kadomatsu Kenji, Miida Takashi, Sekido Yoshitaka
CANCER SCIENCE Vol. 109 page: 625-625 2018.12
Synthetic lethal genes in MYCN-amplified neuroblastoma cells and their potential for therapeutic application
Kiyonari Shinichi, Kadomatsu Kenji
CANCER SCIENCE Vol. 109 page: 1028-1028 2018.12
The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases. Reviewed
Mori Y, Masuda T, Kosugi T, Yoshioka T, Hori M, Nagaya H, Maeda K, Sato Y, Kojima H, Kato N, Ishimoto T, Katsuno T, Yuzawa Y, Kadomatsu K, Maruyama S.
Clin. Exp. Nephrol. Vol. 22 ( 4 ) page: 815-824 2018.8
Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice
Doke Tomohito, Ishimoto Takuji, Hayasaki Takahiro, Ikeda Satsuki, Hasebe Masako, Hirayama Akiyoshi, Soga Tomoyoshi, Kato Noritoshi, Kosugi Tomoki, Tsuboi Naotake, Lanaspa Miguel A., Johnson Richard J., Kadomatsu Kenji, Maruyama Shoichi
METABOLISM-CLINICAL AND EXPERIMENTAL Vol. 85 page: 161-170 2018.8
Origin and initiation mechanisms of neuroblastoma. Reviewed
Tsubota S, Kadomatsu K.
Cell Tissue Res. Vol. 372 ( 2 ) page: 211-221 2018.5
Midkine Promotes Atherosclerotic Plaque Formation Through Its Pro-Inflammatory, Angiogenic and Anti-Apoptotic Functions in Apolipoprotein E-Knockout Mice. Reviewed
Takemoto Y, Horiba M, Harada M, Sakamoto K, Takeshita K, Murohara T, Kadomatsu K, Kamiya K.
Circ. J. Vol. 82 ( 1 ) page: 19-27 2017.12
Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes. Reviewed
Su Z, Kishida S, Tsubota S, Sakamoto K, Cao D, Kiyonari S, Ohira M, Kamijo T, Narita A, Xu Y, Takahashi Y, Kadomatsu K.
Oncotarget Vol. 8 ( 63 ) page: 106296-106310 2017.11
A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-kB degradation and cell growth suppression in neuroblastoma. Reviewed
Mu Ping., Akashi, T., Lu, F., Kishida, S. and Kadomatsu, K.
Oncogene Vol. 36 ( 41 ) page: 5745-5756 2017.10
PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma. Reviewed
Tsubota S, Kishida S, Shimamura T, Ohira M, Yamashita S, Cao D, Kiyonari S, Ushijima T, Kadomatsu K.
Cancer Res. Vol. 77 ( 19 ) page: 5259-5271 2017.10
Mechanisms of axon regeneration: The significance of proteoglycans. Reviewed
Sakamoto K, Kadomatsu K.
Biochim. Biophys. Acta Gen. Subj. Vol. 1861 ( 10 ) page: 2435-2441 2017.10
Origin and mechanism of neuroblastoma.
Tsubota S, Kadomatsu K.
Oncoscience Vol. 4 ( 7-8 ) page: 70-72 2017.9
Dual inhibition of P-glycoprotein and midkine may increase therapeutic effects of anticancer drugs. Reviewed
Aynacıoğlu AŞ, Bilir A, Kadomatsu K.
Med. Hypotheses Vol. 107 page: 26-28 2017.9
Temporally and Spatially Regulated Expression of the Linker Histone H1fx During Mouse Development. Reviewed
Ichihara-Tanaka K, Kadomatsu K, Kishida S.
J. Histochem. Cytochem. Vol. 65 ( 9 ) page: 513-530 2017.9
Differential activation of neuronal and glial STAT3 in the spinal cord of the SOD1G93A mouse model of amyotrophic lateral sclerosis. Reviewed
Ohgomori T, Yamasaki R, Takeuchi H, Kadomatsu K, Kira JI, Jinno S.
Eur. J. Neurosci. Vol. 46 ( 4 ) page: 2001-2014 2017.8
Involvement of midkine in the development of pulmonary fibrosis. Reviewed
Misa K, Tanino Y, Wang X, Nikaido T, Kikuchi M, Sato Y, Togawa R, Tanino M, Tanaka S, Kadomatsu K, Munakata M.
Physiol. Rep. Vol. 5 ( 16 ) 2017.8
Efficacy of urinary midkine as a biomarker in patients with acute kidney injury.
Hayashi H, Sato W, Kosugi T, Nishimura K, Sugiyama D, Asano N, Ikematsu S, Komori K, Nishiwaki K, Kadomatsu K, Matsuo S, Maruyama S, Yuzawa Y.
Clin. Exp. Nephrol. Vol. 21 ( 4 ) page: 597-607 2017.8
Differential activation of neuronal and glial STAT3 in the spinal cord of the SOD1G93A mouse model of amyotrophic lateral sclerosis.
Ohgomori T, Yamasaki R, Takeuchi H, Kadomatsu K, Kira JI, Jinno S.
Neuroscience Vol. 356 page: 114-124 2017.7
Neuroblastoma stem cells and CFC1. Reviewed
Tsubota S, Kadomatsu K.
Oncotarget Vol. 8 ( 28 ) page: 45032-45033 2017.7
Sulfatase 2 Modulates Fate Change from Motor Neurons to Oligodendrocyte Precursor Cells through Coordinated Regulation of Shh Signaling with Sulfatase 1. Reviewed
Jiang W, Ishino Y, Hashimoto H, Keino-Masu K, Masu M, Uchimura K, Kadomatsu K, Yoshimura T, Ikenaka K.
Dev. Neurosci. Vol. 39 ( 5 ) page: 361-374 2017.5
Dissecting the interaction between tissue inhibitor of metalloproteinases-3 (TIMP-3) and low density lipoprotein receptor-related protein-1 (LRP-1): Development of a "TRAP" to increase levels of TIMP-3 in the tissue.
Scilabra SD, Yamamoto K, Pigoni M, Sakamoto K, Müller SA, Papadopoulou A, Lichtenthaler SF, Troeberg L, Nagase H, Kadomatsu K.
Matrix Biol. Vol. 59 page: 69-79 2017.5
INDUCTION OF IMMUNOSUPPRESSIVE MICRO-RNA IN SPLEEN ATTENUATES SEPSIS INDUCED ACUTE KIDNEY INJURY
Funahashi Yoshio, Kato Noritoshi, Ishimoto Takuji, Kosugi Tomoki, Tsuboi Naotake, Kadomatsu Kenji, Maruyama Shoichi
NEPHROLOGY DIALYSIS TRANSPLANTATION Vol. 32 page: . 2017.5
Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology. Reviewed
Zhang Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, Narentuya, Akatsu H, Nishitsuji K, Michikawa M, Wyss-Coray T, Kadomatsu K, Uchimura K.
Proc. Natl. Acad. Sci. U S A Vol. 114 ( 14 ) page: E2947-E2954 2017.4
Growth Factor Midkine Promotes T-Cell Activation through Nuclear Factor of Activated T Cells Signaling and Th1 Cell Differentiation in Lupus Nephritis. Reviewed
Masuda T, Maeda K, Sato W, Kosugi T, Sato Y, Kojima H, Kato N, Ishimoto T, Tsuboi N, Uchimura K, Yuzawa Y, Maruyama S, Kadomatsu K.
Am. J. Pathol. Vol. 187 ( 4 ) page: 740-751 2017.4
Correction of spherical aberration in multi-focal multiphoton microscopy with spatial light modulator.
Matsumoto N, Konno A, Ohbayashi Y, Inoue T, Matsumoto A, Uchimura K, Kadomatsu K, Okazaki S.
Opt. Express Vol. 25 ( 6 ) page: 7055-7068 2017.3
GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system. Reviewed
Yoshimura T, Hayashi A, Handa-Narumi M, Yagi H, Ohno N, Koike T, Yamaguchi Y, Uchimura K, Kadomatsu K, Sedzik J, Kitamura K, Kato K, Trapp BD, Baba H, Ikenaka K.
Sci. Rep. Vol. 7 page: 42257 2017.2
Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma. Reviewed
Ho WL, Hsu WM, Huang MC, Kadomatsu K, Nakagawara A.
J. Hematol. Oncol. Vol. 9 ( 1 ) page: 100 2016.9
SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells.
Murakami-Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, Komata Y, Jan Koster, Takeuchi I, Kondo Y, Maeda T, Sekido Y, Murakami H, Kadomatsu K.
Sci. Rep. Vol. 6 page: 31615 2016.8
Nogo receptor 1 is expressed in both primary cultured glial cells and neurons.
Ukai J, Imagama S, Ohgomori T, Ito Z, Ando K, Ishiguro N, Kadomatsu K.
Nagoya J. Med. Sci. Vol. 3 ( 78 ) page: 303-311 2016.8
Reduced molecular size and altered disaccharide composition of cerebral chondroitin sulfate upon Alzheimer's pathogenesis in mice. Reviewed
Zhang Z, Ohtake-Niimi S, Kadomatsu K, Uchimura K.
Nagoya J. Med. Sci. Vol. 78 ( 3 ) page: 293-301 2016.8
Comparative morphometric analysis of microglia in the spinal cord of SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis.
Ohgomori T, Yamada J, Takeuchi H, Kadomatsu K, Jinno S.
Eur. J. Neurosci. Vol. 10 ( 43 ) page: 1340-1351 2016.5
Midkine Deteriorates Cardiac Remodeling via Epidermal Growth Factor Receptor Signaling in Chronic Kidney Disease.
Honda Y, Shishido T, Takahashi T, Watanabe T, Netsu S, Kinoshita D, Narumi T, Kadowaki S, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Kishida S, Kadomatsu K, Takeishi Y, Kubota I.
Hypertension Vol. 5 ( 67 ) page: 857-865 2016.5
Basigin Promotes Cardiac Fibrosis and Failure in Response to Chronic Pressure Overload in Mice.
Suzuki K, Satoh K, Ikeda S, Sunamura S, Otsuki T, Satoh T, Kikuchi N, Omura J, Kurosawa R, Nogi M, Numano K, Sugimura K, Aoki T, Tatebe S, Miyata S, Mukherjee R, Spinale FG, Kadomatsu K, Shimokawa H
Arterioscler. Thromb. Vasc. Biol. Vol. 4 ( 36 ) page: 636-646 2016.4
Keratan Sulfate Regulates the Switch from Motor Neuron to Oligodendrocyte Generation During Development of the Mouse Spinal Cord.
Neurochem. Res. Vol. 41 ( 1-2 ) page: 450-462 2016.2
Exogenous midkine administration prevents cardiac remodeling in pacing-induced congestive heart failure of rabbits.
Harada M, Hojo M, Kamiya K, Kadomatsu K, Murohara T, Kodama I, Horiba M.
Heart Vessels Vol. 1 ( 31 ) page: 96-104 2016.1
Requirement of keratan sulfate proteoglycan phosphacan with a specific sulfation pattern for critical period plasticity in the visual cortex. Reviewed
Takeda-Uchimura Y, Uchimura K, Sugimura T, Yanagawa Y, Kawasaki T, Komatsu Y, Kadomatsu K.
Exp. Neurol. Vol. 274 ( Pt B ) page: 145-155 2015.12
Introduction to glyco-neuroscience.
Exp. Neurol. Vol. 274 ( Pt B ) page: 89 2015.12
Time-dependent localization of high- and low-sulfated keratan sulfates in the song nuclei of developing zebra finches.
Fujimoto H, Ohgomori T, Abe K, Uchimura K, Kadomatsu K, Jinno S.
Eur. J. Neurosci. Vol. 42 ( 9 ) page: 2716-2725 2015.11
The 1,2-diaminocyclohexane carrier ligand in oxaliplatin induces p53-dependent transcriptional repression of factors involved in thymidylate biosynthesis. Reviewed
Kiyonari S, Iimori M, Matsuoka K, Watanabe S, Morikawa-Ichinose T, Miura D, Niimi S, Saeki H, Tokunaga E, Oki E, Morita M, Kadomatsu K, Maehara Y, Kitao H.
Mol. Cancer Ther. Vol. 14 ( 10 ) page: 2332-2342 2015.10
Microglial Keratan Sulfate Epitope Elicits in Central Nervous Tissues of Transgenic Model Mice and Patients with Amyotrophic Lateral Sclerosis.
Foyez T, Takeda-Uchimura Y, Ishigaki S, Narentuya, Zhang Z, Sobue G, Kadomatsu K, Uchimura K.
Am. J. Pathol. Vol. 185 ( 11 ) page: 3053-3065 2015.9
Keratan sulfate exacerbates experimental autoimmune encephalomyelitis.
Ueno R, Miyamoto K, Tanaka N, Moriguchi K, Kadomatsu K, Kusunoki S.
J. Neurosci. Res. Vol. 93 ( 12 ) page: 1874-1880 2015.9
Midkine Regulates BP through Cytochrome P450-Derived Eicosanoids. Reviewed
Sato Y, Sato W, Maruyama S, Wilcox CS, Falck JR, Masuda T, Kosugi T, Kojima H, Maeda K, Furuhashi K, Ando M, Imai E, Matsuo S, Kadomatsu K.
J. Am. Soc. Nephrol. Vol. 26 ( 8 ) page: 1806-1815 2015.8
CD147 (EMMPRIN/Basigin) in kidney diseases: from an inflammation and immune system viewpoint. Reviewed
Kosugi T, Maeda K, Sato W, Maruyama S, Kadomatsu K.
Nephrol. Dial. Transplant Vol. 30 ( 7 ) page: 1097-1103 2015.7
Reductions of docosahexaenoic acid-containing phosphatidylcholine levels in the anterior horn of an ALS mouse model. Reviewed
Arima H, Omura T, Hayasaka T, Masaki N, Hanada M, Xu D, Banno T, Kobayashi K, Takeuchi H, Kadomatsu K, Matsuyama Y, Setou M.
Neuroscience Vol. 2 ( 297 ) page: 127-136 2015.6
A proliferation-inducing ligand sustains the proliferation of human naïve (CD27-) B cells and mediates their differentiation into long-lived plasma cells in vitro via transmembrane activator and calcium modulator and cyclophilin ligand interactor and B-cell mature antigen. Reviewed
Matsuda Y, Haneda M, Kadomatsu K, Kobayashi T.
Cell Immunol. Vol. 295 ( 2 ) page: 127-136 2015.6
EML4 promotes the loading of NUDC to the spindle for mitotic progression. Reviewed
Chen D, Ito S, Yuan H, Hyodo T, Kadomatsu K, Hamaguchi M, Senga T.
Cell Cycle Vol. 14 ( 10 ) page: 1529-1539 2015.5
CD147/Basigin limits lupus nephritis and TH 17 cell differentiation by inhibiting the IL-6/STAT3 pathway. Reviewed
Maeda K, Kosugi T, Sato W, Kojima H, Sato Y, Kamimura D, Kato N, Tsuboi N, Yuzawa Y, Matsuo S, Murakami M, Maruyama S, Kadomatsu K.
Arthritis Rheumatol. Vol. 67 ( 8 ) page: 2185-2195 2015.5
A combination of keratan sulfate digestion and rehabilitation promotes anatomical plasticity after rat spinal cord injury. Reviewed
Ishikawa Y, Imagama S, Ohgomori T, Ishiguro N, Kadomatsu K.
Neurosci. Lett. Vol. 593 page: 13-18 2015.4
NeuroD1 promotes neuroblastoma cell growth by inducing the expression of ALK. Reviewed
Lu F, Kishida S, Mu P, Huang P, Cao D, Tsubota S, Kadomatsu K.
Cancer Sci. Vol. 106 ( 4 ) page: 390-396 2015.4
Atelocollagen-Mediated Intravenous siRNA Delivery Specific to Tumor Tissues Orthotopically Xenografted in Prostates of Nude Mice and Its Anticancer Effects. Reviewed
Yuan Y, Makita N, Cao D, Mihara K, Kadomatsu K, Takei Y.
Nucleic Acid Ther. Vol. 25 ( 2 ) page: 85-94 2015.4
The nucleolar protein PES1 is a marker of neuroblastoma outcome and is associated with neuroblastoma differentiation. Reviewed
Nakaguro M, Kiyonari S, Kishida S, Cao D, Murakami-Tonami Y, Ichikawa H, Takeuchi I, Nakamura S, Kadomatsu K.
Cancer Sci. Vol. 106 ( 3 ) page: 237-243 2015.3
Neuroblastoma models for insights into tumorigenesis and new therapies. Reviewed
Kiyonari S, Kadomatsu K.
Expert Opin. Drug Discov. Vol. 10 ( 1 ) page: 53-62 2015.1
CD147/basigin reflects renal dysfunction in patients with acute kidney injury. Reviewed
Nagaya H, Kosugi T, Maeda-Hori M, Maeda K, Sato Y, Kojima H, Hayashi H, Kato N, Ishimoto T, Sato W, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.
Clin. Exp. Nephrol. Vol. 18 ( 5 ) page: 746-754 2014.10
Basigin mediates pulmonary hypertension by promoting inflammation and vascular smooth muscle cell proliferation. Reviewed
Satoh K, Satoh T, Kikuchi N, Omura J, Kurosawa R, Suzuki K, Sugimura K, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Miura M, Shimizu T, Ikeda S, Yaoita N, Fukumoto Y, Minami T, Miyata S, Nakamura K, Ito H, Kadomatsu K, Shimokawa H.
Circ. Res. Vol. 115 ( 8 ) page: 738-750 2014.9
Mechanisms of axon regeneration and its inhibition: roles of sulfated glycans. Reviewed
Kadomatsu K, Sakamoto K.
Arch. Biochem. Biophys. Vol. 558 page: 36-41 2014.9
Keratan sulfate expression is associated with activation of a subpopulation of microglia/macrophages in Wallerian degeneration. Reviewed
Shinjo R, Imagama S, Ito Z, Ando K, Nishida Y, Ishiguro N, Kadomatsu K.
Neurosci. Lett. Vol. 579 page: 80-85 2014.9
An EMMPRIN-γ-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions. Reviewed
Moreno V, Gonzalo P, Gómez-Escudero J, Pollán Á, Acín-Pérez R, Breckenridge M, Yáñez-Mó M, Barreiro O, Orsenigo F, Kadomatsu K, Chen CS, Enríquez JA, Dejana E, Sánchez-Madrid F, Arroyo AG.
J. Cell Sci. Vol. 127 page: 3768-3781 2014.9
Chondroitin 6-O-sulfate ameliorates experimental autoimmune encephalomyelitis. Reviewed
Miyamoto K, Tanaka N, Moriguchi K, Ueno R, Kadomatsu K, Kitagawa H, Kusunoki S.
Glycobiology Vol. 24 ( 5 ) page: 469-475 2014.5
Plasma CD147 reflects histological features in patients with lupus nephritis. Reviewed
Maeda-Hori M, Kosugi T, Kojima H, Sato W, Inaba S, Maeda K, Nagaya H, Sato Y, Ishimoto T, Ozaki T, Tsuboi N, Muro Y, Yuzawa Y, Imai E, Johnson R, Matsuo S, Kadomatsu K, Maruyama S.
Lupus Vol. 23 ( 4 ) page: 342-352 2014.4
Midkine: an emerging target of drug development for treatment of multiple diseases. Reviewed
Muramatsu T, Kadomatsu K.
Br. J. Pharmacol. Vol. 171 ( 4 ) page: 811-813 2014.2
Involvement of midkine in neuroblastoma tumourigenesis. Reviewed
Kishida S, Kadomatsu K.
Br. J. Pharmacol. Vol. 171 ( 4 ) page: 896-904 2014.2
KSGal6ST Is Essential for the 6-Sulfation of Galactose within Keratan Sulfate in Early Postnatal Brain. Reviewed
Hoshino H, Foyez T, Ohtake-Niimi S, Takeda-Uchimura Y, Michikawa M, Kadomatsu K, Uchimura K.
J. Histochem. Cytochem. Vol. 62 ( 2 ) page: 145-156 2014.2
Therapeutic potential of midkine in cardiovascular disease. Reviewed
Kadomatsu K, Bencsik P, Görbe A, Csonka C, Sakamoto K, Kishida S, Ferdinandy P.
Br. J. Pharmacol. Vol. 171 ( 4 ) page: 936-944 2014.2
A new tumorsphere culture condition restores potentials of self-renewal and metastasis of primary neuroblastoma in a mouse neuroblastoma model. Reviewed
Cao D, Kishida S, Huang P, Mu P, Tsubota S, Mizuno M, Kadomatsu K.
PLoS One Vol. 9 ( 1 ) page: e86813 2014.1
Sulfated glycans in network rewiring and plasticity after neuronal injuries. Reviewed
Kadomatsu K, Sakamoto K.
Neurosci. Res. Vol. 78 page: 50-54 2014.1
Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells. Reviewed
Murakami-Tonami Y, Kishida S, Takeuchi I, Katou Y, Maris JM, Ichikawa H, Kondo Y, Sekido Y, Shirahige K, Murakami H, Kadomatsu K.
Cell Cycle Vol. 13 ( 7 ) page: 1115-1131 2014
ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma. Reviewed
Hasan MK, Nafady A, Takatori A, Kishida S, Ohira M, Suenaga Y, Hossain S, Akter J, Ogura A, Nakamura Y, Kadomatsu K, Nakagawara A.
Sci. Rep. Vol. 3 page: 3450 2013.12
Keratan sulfate expression in microglia is diminished in the spinal cord in experimental autoimmune neuritis. Reviewed
Matsui H, Ohgomori T, Natori T, Miyamoto K, Kusunoki S, Sakamoto K, Ishiguro N, Imagama S, Kadomatsu K.
Cell Death Dis. Vol. 4 page: e946 2013.12
Discovering combinatorial interactions in survival data. Reviewed
Duverle DA, Takeuchi I, Murakami-Tonami Y, Kadomatsu K, Tsuda K.
Bioinformatics Vol. 29 ( 23 ) page: 3053-3059 2013.12
Expression of midkine in normal human skin, dermatitis and neoplasms: association with differentiation of keratinocytes. Reviewed
Vol. 40 ( 12 ) page: 980-986 2013.12
Midkine overcomes neurite outgrowth inhibition of chondroitin sulfate proteoglycan without glial activation and promotes functional recovery after spinal cord injury.
Muramoto A, Imagama S, Natori T, Wakao N, Ando K, Tauchi R, Hirano K, Shinjo R, Matsumoto T, Ishiguro N, Kadomatsu K.
Neurosci. Lett. Vol. 550 page: 150-155 2013.8
Ablation of keratan sulfate accelerates early phase pathogenesis of ALS. Reviewed
Hirano K, Ohgomori T, Kobayashi K, Tanaka F, Matsumoto T, Natori T, Matsuyama Y, Uchimura K, Sakamoto K, Takeuchi H, Hirakawa A, Suzumura A, Sobue G, Ishiguro N, Imagama S, Kadomatsu K.
PLoS One Vol. 8 ( 6 ) page: e66969 2013.6
The heparin-binding growth factor midkine: the biological activities and candidate receptors.
Kadomatsu K, Kishida S, Tsubota S.
J. Biochem. Vol. 153 ( 6 ) page: 511-521 2013.6
Minocycline selectively inhibits M1 polarization of microglia. Reviewed
Kobayashi K, Imagama S, Ohgomori T, Hirano K, Uchimura K, Sakamoto K, Hirakawa A, Takeuchi H, Suzumura A, Ishiguro N, Kadomatsu K.
Cell Death Dis. Vol. 4 page: e525 2013.3
Midkine promotes neuroblastoma through Notch2 signaling. Reviewed
Kishida S, Mu P, Miyakawa S, Fujiwara M, Abe T, Sakamoto K, Onishi A, Nakamura Y, Kadomatsu K.
Cancer Res. Vol. 73 ( 4 ) page: 1318-1327 2013.2
Deficiency of growth factor midkine exacerbates necrotizing glomerular injuries in progressive glomerulonephritis.
Kojima H, Kosugi T, Sato W, Sato Y, Maeda K, Kato N, Kato K, Inaba S, Ishimoto T, Tsuboi N, Matsuo S, Maruyama S, Yuzawa Y, Kadomatsu K.
Am. J. Pathol. Vol. 182 ( 2 ) page: 410-419 2013.2
Midkine in the pathology of cancer, neural disease, and inflammation. Reviewed
Sakamoto K, Kadomatsu K.
Pathol. Int. Vol. 62 ( 7 ) page: 445-455 2012.7
CD44 expression in astrocytes and microglia is associated with ALS progression in a mouse model. Reviewed
Matsumoto T, Imagama S, Hirano K, Ohgomori T, Natori T, Kobayashi K, Muramoto A, Ishiguro N, Kadomatsu K.
Neurosci. Lett. Vol. 520 ( 1 ) page: 115-120 2012.6
ADAMTS-13 is produced by glial cells and upregulated after spinal cord injury. Reviewed
Tauchi R, Imagama S, Ohgomori T, Natori T, Shinjo R, Ishiguro N, Kadomatsu K.
Neurosci. Lett. Vol. 517 ( 1 ) page: 1-6 2012.5
The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury. Reviewed
Tauchi R, Imagama S, Natori T, Ohgomori T, Muramoto A, Shinjo R, Matsuyama Y, Ishiguro N, Kadomatsu K.
J. Neuroinflammation Vol. 9 page: 53 2012.3
Midkine inhibits inducible regulatory T cell differentiation by suppressing the development of tolerogenic dendritic cells. Reviewed
Sonobe Y, Li H, Jin S, Kishida S, Kadomatsu K, Takeuchi H, Mizuno T, Suzumura A.
J. Immunol. Vol. 188 ( 6 ) page: 2602-2611 2012.3
Establishment and optimal culture conditions of microrna-induced pluripotent stem cells generated from HEK293 cells via transfection of microrna-302s expression vector. Reviewed
Koide N, Yasuda K, Kadomatsu K, Takei Y.
Nagoya J. Med. Sci. Vol. 74 ( 1-2 ) page: 157-165 2012.2
Atelocollagen-mediated systemic delivery prevents immunostimulatory adverse effects of siRNA in mammals. Reviewed
Inaba S, Nagahara S, Makita N, Tarumi Y, Ishimoto T, Matsuo S, Kadomatsu K, Takei Y.
Mol. Ther. Vol. 20 ( 2 ) page: 356-366 2012.2
Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms. Reviewed
Sakai K, Yamamoto A, Matsubara K, Nakamura S, Naruse M, Yamagata M, Sakamoto K, Tauchi R, Wakao N, Imagama S, Hibi H, Kadomatsu K, Ishiguro N, Ueda M.
J. Clin. Invest. Vol. 122 ( 1 ) page: 80-90 2012.1
Keratan sulfate restricts neural plasticity after spinal cord injury. Reviewed
Imagama S, Sakamoto K, Tauchi R, Shinjo R, Ohgomori T, Ito Z, Zhang H, Nishida Y, Asami N, Takeshita S, Sugiura N, Watanabe H, Yamashita T, Ishiguro N, Matsuyama Y, Kadomatsu K.
J. Neurosci. Vol. 31 ( 47 ) page: 17091-17102 2011.11
EMMPRIN modulates epithelial barrier function through a MMP-mediated occludin cleavage: implications in dry eye disease. Reviewed
Huet E, Vallée B, Delbé J, Mourah S, Prulière-Escabasse V, Tremouilleres M, Kadomatsu K, Doan S, Baudouin C, Menashi S, Gabison EE.
Am. J. Pathol. Vol. 179 ( 3 ) page: 1278-1286 2011.9
A single intracoronary injection of midkine reduces ischemia/reperfusion injury in Swine hearts: a novel therapeutic approach for acute coronary syndrome. Reviewed
Ishiguro H, Horiba M, Takenaka H, Sumida A, Opthof T, Ishiguro YS, Kadomatsu K, Murohara T, Kodama I.
Front. Physiol. Vol. 2 page: 27 2011.6
Keratan sulfate and related murine glycosylation can suppress murine cartilage damage in vitro and in vivo. Reviewed
Hayashi M, Kadomatsu K, Kojima T, Ishiguro N.
Biochem. Biophys. Res. Commun. Vol. 409 ( 4 ) page: 732-737 2011.6
Growth factor Midkine is involved in the pathogenesis of renal injury induced by protein overload containing endotoxin. Reviewed
Kato K, Kosugi T, Sato W, Arata-Kawai H, Ozaki T, Tsuboi N, Ito I, Tawada H, Yuzawa Y, Matsuo S, Kadomatsu K, Maruyama S.
Clin. Exp. Nephrol. Vol. 15 ( 3 ) page: 346-354 2011.6
The Neuronal Differentiation Factor NeuroD1 Downregulates Slit2 Expression and Promotes Cell Motility and Tumor Formation of Neuroblastoma. Reviewed
Huang P, Kishida S, Cao D, Murakami-Tonami Y, Mu P, Nakaguro M, Koide N, Takeuchi I, Onishi A, Kadomatsu K.
Cancer Res. Vol. 71 ( 8 ) page: 2938-2948 2011.4
Premature ligand-receptor interaction during biosynthesis limits the production of growth factor midkine and its receptor LDL receptor-related protein 1. Reviewed
Sakamoto K, Bu G, Chen S, Takei Y, Hibi K, Kodera Y, McCormick LM, Nakao A, Noda M, Muramatsu T, Kadomatsu K.
J. Biol. Chem. Vol. 286 ( 10 ) page: 8405-8413 2011.3
[Proteoglycans and neural circuit reconstruction] Reviewed
Kadomatsu K.
Seikagaku Vol. 83 ( 3 ) page: 240-246 2011.3
Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. Reviewed
Kato N, Kosugi T, Sato W, Ishimoto T, Kojima H, Sato Y, Sakamoto K, Maruyama S, Yuzawa Y, Matsuo S, Kadomatsu K.
Am. J. Pathol. Vol. 178 ( 2 ) page: 572-579 2011.2
Hyaluronan oligosaccharides promote functional recovery after spinal cord injury in rats. Reviewed
Wakao N, Imagama S, Zhang H, Tauchi R, Muramoto A, Natori T, Takeshita S, Ishiguro N, Matsuyama Y, Kadomatsu K.
Neurosci. Lett. Vol. 488 ( 3 ) page: 299-304 2011.1
Keratan sulfate in neuronal network reconstruction. Reviewed
Sakamoto K, Kadomatsu K.
Trends Glycosci. Glycotechnol. Vol. 23 page: 212-220 2011
Keratan sulfate suppresses cartilage damage and ameliorates inflammation in an experimental mice arthritis model. Reviewed
Hayashi M, Kadomatsu K, Ishiguro N.
Biochem. Biophys. Res. Commun. Vol. 401 ( 3 ) page: 463-468 2010.10
N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury. Reviewed
Ito Z, Sakamoto K, Imagama S, Matsuyama Y, Zhang H, Hirano K, Ando K, Yamashita T, Ishiguro N, Kadomatsu K.
J. Neurosci. Vol. 30 ( 17 ) page: 5937-5947 2010.4
DRR1 is expressed in the developing nervous system and downregulated during neuroblastoma carcinogenesis. Reviewed
Asano Y, Kishida S, Mu P, Sakamoto K, Murohara T, Kadomatsu K.
Biochem. Biophys. Res. Commun. Vol. 394 ( 3 ) page: 829-835 2010.4
Midkine gene transfer after myocardial infarction in rats prevents remodelling and ameliorates cardiac dysfunction. Reviewed
Sumida A, Horiba M, Ishiguro H, Takenaka H, Ueda N, Ooboshi H, Opthof T, Kadomatsu K, Kodama I.
Cardiovasc Res. Vol. 86 ( 1 ) page: 113-121 2010.4
Midkine regulation of the renin-angiotensin system. Reviewed
Kadomatsu K.
Curr. Hypertens. Rep. Vol. 12 ( 2 ) page: 74-79 2010.4
Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation. Reviewed
Miwa Y, Yamamoto K, Onishi A, Iwamoto M, Yazaki S, Haneda M, Iwasaki K, Liu D, Ogawa H, Nagasaka T, Uchida K, Nakao A, Kadomatsu K, Kobayashi T.
Xenotransplantation Vol. 17 ( 1 ) page: 26-37 2010.2
Systemic delivery of siRNA specific to tumor mediated by atelocollagen: Combined therapy using siRNA targeting Bcl-xL and cisplatin against prostate cancer. Reviewed
Mu, P., Nagahara, S., Makita, N., Tarumi, Y., Kadomatsu, K., Takei, Y.
Int. J. Cancer Vol. 125 ( 12 ) page: 2978-2990 2009.12
Successful cross-breeding of cloned pigs expressing endo-beta-galactosidase C and human decay accelerating factor. Reviewed
Yazaki S, Iwamoto M, Onishi A, Miwa Y, Suzuki S, Fuchimoto D, Sembon S, Furusawa T, Hashimoto M, Oishi T, Liu D, Nagasaka T, Kuzuya T, Maruyama S, Ogawa H, Kadomatsu K, Uchida K, Nakao A, Kobayashi T.
Xenotransplantation Vol. 16 ( 6 ) page: 511-521 2009.11
Disruption of the midkine gene (Mdk) delays degeneration and regeneration in injured peripheral nerve. Reviewed
Sakakima H, Yoshida Y, Yamazaki Y, Matsuda F, Ikutomo M, Ijiri K, Muramatsu H, Muramatsu T, Kadomatsu K.
J. Neurosci. Res. Vol. 87 ( 13 ) page: 2908-2915 2009.10
The E-selectin ligand Basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion. Reviewed
Kato, N., Yuzawa, Y., Kosugi, T., Hobo, A., Sato, W., Miwa, Y., Sakamoto, K., Matsuo, S., Kadomatsu, K.
J. Am. Soc. Nephrol. Vol. 20 ( 7 ) page: 1565-1576 2009.7
The growth factor midkine regulates the renin-angiotensin system in mice. Reviewed
Hobo, A., Yuzawa, Y., Kosugi, T., Kato, N., Asai, N., Sato, W., Maruyama, S., Ito, Y., Kobori, H., Ikematsu, S., Akira Nishiyama, A., Matsuo, S., Kadomatsu, K.
J. Clin. Invest. Vol. 119 ( 6 ) page: 1616-1625 2009.6
Transforming growth factor-β1 upregulates keratan sulfate and chondroitin sulfate biosynthesis in microglias after brain injury. Reviewed
Yin, J., Sakamoto, K., Zhang, H., Ito, Z., Imagama, S., Kishida, S., Natori, T., Sawada, M., Matsuyama, Y., Kadomatsu, K.
Brain Res. Vol. 1263 page: 10-22 2009.3
Midkine prevents ventricular remodeling and improves long-term survival after myocardial infarction. Reviewed
Takenaka, H., Horiba, M., Ishiguro, H., Sumida, A., Hojo, M., Usui, A., Akita, T., Sakuma, S., Ueda, Y., Kodama, I., Kadomatsu, K.
Am. J. Physiol. Heart Circ. Physiol. Vol. 296 ( 2 ) page: 462-469 2009.2
Removal of blood group A/B antigen in organs by ex vivo and in vivo administration of ando-β-galactosidase (ABase) for ABO incompatible transplantation. Reviewed
Kobayashi, T., Liu, D., Ogawa, H., Miwa, Y., Nagasaka, T., Maruyama. S., Li, Y., Onishi, A., Iwamoto, M., Kuzuya, T., Kadomatsu, K., Uchida, K., Nakao, A.
Transplant Immunol. Vol. 20 ( 3 ) page: 132-138 2009.1
Basal and stimulated lactate fluxes in primary cultures of astrocytes are differentially controlled by distinct proteins. Reviewed
Maekawa, F., Minehira, K., Kadomatsu, K., Pellerin, L.
J. Neurochem. Vol. 107 ( 3 ) page: 789-798 2008.11
Plasma midkine leveliIs a prognostic factor for human neuroblastoma. Reviewed
Ikematsu, S., Nakagawara, A., Nakamura, Y., Ohira, M., Shinjo, M., Satoshi Kishida, S., Kadomatsu, K.
Cancer Sci. Vol. 99 ( 10 ) page: 2070-2074 2008.10
Expression and roles of a xenopus head-forming gene homologue in human cancer cell lines. Reviewed
Zhu, Y., Tsuchida, A., Yamamoto, A., Furukawa, K., Tajima, O., Tokuda, N., Aizawa, S., Urano, T., Kadomatsu, K, Furukawa, K.
Nagoya J. Med. Sci. Vol. 70 ( 3-4 ) page: 73-82 2008.8
Midkine is expressed by infiltrating macrophages in in-stent restenosis in hypercholesterolemic rabbits. Reviewed
Narita, H., Chen, S., Komori, K., Kadomatsu, K.
J. Vas. Surg. Vol. 47 ( 6 ) page: 1322-1329 2008.6
Midkine and its clinical significance in endometrial carcinoma. Reviewed
Tanabe, K., Matsumoto, M., Ikematsu, S., Nagase, S., Hatakeyama, A., Takano, T., Niikura, H., Ito, K., Kadomatsu, K., Hayashi, S., Yaegashi, N.
Cancer Sci. Vol. 99 ( 6 ) page: 1125-1130 2008.6
Downregulation of monocyte chemoattractant protein-1 involving short interfering RNA attenuates Hapten-induced contact hypersensitivity. Reviewed
Ishimoto, T., Takei, Y. Yuzawa, Y., Hanai, K., Nagahara, S., Tarumi, Y., Matsuo, S., Kadomatsu, K.
Mol. Ther. Vol. 16 ( 2 ) page: 387-395 2008.2
In vivo silencing of a molecular target by short interfering RNA electroporation: Tumor vascularization correlates to delivery efficiency. Reviewed
Takei, Y., Nemoto, T., Mu, P., Fujishima, T., Ishimoto, T., Hayakawa, Y., Yuzawa, Y., Matsuo, S., Muramatsu, T., Kadomatsu, K.
Mol. Cancer Ther. Vol. 7 ( 1 ) page: 211-221 2008.1
Midkine and LDL receptor-related protein 1 contribute to the anchorage -independent cell growth of cancer cells. Reviewed
Chen, S., Bu, G., Takei, Y., Sakamoto, K., Ikematsu, S., Muramatsu, T., Kadomatsu, K.
J.Cell Sci. Vol. 120 ( Pt22 ) page: 4009-4015 2007.11
Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. Reviewed
Ishiguro K, Ando T, Maeda O, Ohmiya N, Niwa Y, Kadomatsu K, Goto H.
Biochem. Biophys. Res. Commun. Vol. 362 ( 1 ) page: 218-223 2007.10
Midkine is involved in tubulo-interstitial inflammation associated with diabetic nephropathy. Reviewed
Kosugi, T., Yuzawa, Y., Sato, W., Kato, N., Arata-Kawai, H., Matsuo, S., Kadomatsu. K.
Lab. Invest. Vol. 87 ( 9 ) page: 903-913 2007.9
Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia. Reviewed
Hidaka, H., Yagasaki, H. Takahashi, Y., Hama, A., Nishio, N., Tanaka, M, Yoshida, N., Villalobos, I.B., Wang, Y., Xu. Y.Y., Horibe, K., Chen, S., Kadomatsu, K., Kojima, S.
Leukemia Res. Vol. 31 ( 8 ) page: 1045-1051 2007.8
Midkine as a novel target for antibody therapy in osteosarcoma. Reviewed
Maehara H, Kaname T, Yanagi K, Hanzawa H, Owan I, Kinjou T, Kadomatsu K, Ikematsu S, Iwamasa T, Kanaya F, Naritomi K.
Biochem. Biophys. Res. Commun. Vol. 358 ( 3 ) page: 757-762 2007.7
Alternative Strategy for Overcoming ABO Incompatibility. Reviewed
Kobayashi T, Liu D, Ogawa H, Miwa Y, Nagasaka T, Maruyama S, Li YT, Onishi A, Kuzuya T, Kadomatsu K, Uchida K, Nakao A.
Transplantation Vol. 83 ( 9 ) page: 1284-1286 2007.5
Relation between human decay-accelerating factor (hDAF) expression in pig cells and inhibition of human serum anti-pig cytotoxicity: value of highly expressed hDAF for Xenotransplantation. Reviewed
Liu, D., Kobayashi, T., Onishi, A., Furusawa, T., Iwamoto, M., Suzuki, S., Miwa, Y., Nagasaka, T., Maruyama, S., Kadomatsu, K., Uchida, K., Nakao, A.
Xenotransplantation Vol. 14 ( 1 ) page: 67-73 2007.1
Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation. Reviewed
Ishiguro K, Ando T, Maeda O, Hasegawa M, Kadomatsu K, Ohmiya N, Niwa Y, Xavier R, Goto H.
Toxicol. Appl. Pharmacol. Vol. 217 ( 1 ) page: 35-42 2006.11
Brain keratan sulfate and glial scar formation. Reviewed
Zhang, H., Uchimura, K., Kadomatsu, K.
Ann. NY Acad. Sci. Vol. 1086 page: 81-90 2006.11
Midkine plays a protective role against cardiac ischemia /reperfusion Injury through a reduction of apoptotic reaction. Reviewed
Horiba M, Kadomatsu K, Uasui K, Lee J, Takenaka H, Sumida A, Kamiya K, Chen S, Sakuma S, Muramatsu T, Komada I.
Circulation Vol. 114 ( 16 ) page: 1713-1720 2006.10
Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts. Reviewed
Banno H, Takei Y, Muramatsu T, Komori K, Kadomatsu K.
J. Vas. Surg. Vol. 44 ( 3 ) page: 633-641 2006.9
Combinational antitumor effect of siRNA against midkine and paclitaxel on growth of human prostate cancer xenografts. Reviewed
Takei Y, Kadomatsu K, Goto T, Muramatsu T.
Cancer Vol. 107 ( 4 ) page: 864-873 2006.8
N-Acetylglucosamine 6-O-sulfotransferase-1 is required for brain keratan sulfate biosynthesis and glial scar formation after brain injury. Reviewed
Zhang H, Muramatsu T, Murase A, Yuasa S, Uchimura K, Kadomatsu K.
Glycobiology Vol. 16 ( 8 ) page: 702-710 2006.8
Loss of core fucosylation of low-density lipoprotein receptor-related protein-1 impairs its function, leading to the upregulation of serum levels of insulin-like growth factor-binding protein 3 in Fut8-/- mice. Reviewed
Lee SH, Takahashi M, Honke K, Miyoshi E, Osumi D, Sakiyama H, Ekuni A, Wang X, Inoue S, Gu J, Kadomatsu K, Taniguchi N.
J. Biochem. Vol. 139 ( 3 ) page: 391-398 2006.3
Growth factor midkine is involved in the pathogenesis of diabetic nephropathy. Reviewed
Kosugi T, Yuzawa Y, Sato W, Kawai H, Matsuo S, Takei Y, Muramatsu T, Kadomatsu K.
Am. J. Pathol. Vol. 168 ( 1 ) page: 9-19 2006.1
Putative midkine family protein up-regulation in Patella caerulea (Mollusca, Gastropoda) exposed to sublethal concentrations of cadmium. Reviewed
Vanucci S, Minerdi D, Kadomatsu K, Mengoni A, Bazzicalupo M.
Aquat. Toxicol. Vol. 75 ( 4 ) page: 374-379 2005.11
N-Acetylglucosamine-6-O-sulfotransferase-1 and -2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules. Reviewed
Kawashima, H., Petryniak, B., Hiraoka, N., Mitoma, J., Huckaby, V., Nakayama, J., Uchimura, K. Kadomatsu, K., Muramatsu, T., Lowe, J.B., Fukuda, M.
Nat. Immunol. Vol. 6 ( 11 ) page: 1096-1104 2005.11
The midkine family in cancer, inflammation and neural development. Reviewed
Kadomatsu, K.
Nagoya J. Med. Sci. Vol. 67 ( 3-4 ) page: 71-82 2005.6
Antisense oligodeoxyribonucleotide as to the growth factor midkine suppresses neointima formation induced by balloon Injury. Reviewed
Hayashi, K., Banno, H., Kadomatsu, K.*, Takei, Y., Komori, K., Muramatsu, T.
Am. J. Physiol. Heart Circ. Physiol. Vol. 288 ( 5 ) page: 2203-2209 2005.5
Morpholino antisense oligomer targeting human midikine: its application for cancer therapy. Reviewed
Takei, Y., Kadomatsu, K., Yuasa, K., Sato, W., Muramatsu, T.
Int. J. Cancer Vol. 114 ( 3 ) page: 490-497 2005.4
Midkine antisense oligodeoxyribonucleotide inhibits renal damage induced by ischemic reperfusion. Reviewed
Sato, W., Takei, Y., Yuzawa,Y., Matsuo, S., Kadomatsu, K., Muramatsu, T.
Kidney Int. Vol. 67 ( 4 ) page: 1330-1339 2005.4
Postischemic gene transfer of midkine, a neurotrophic factor, protects against focal brain ischemia. Reviewed
Takada, J., Ooboshi, H., Ago, T., Kitazono, T., Yao, H., Kadomatsu, K., Muramatsu, T., Ibayashi, S., Iida, M.
Gene Ther. Vol. 12 ( 6 ) page: 487-493 2005.3
In vivo delivery technique of nucleic acid compounds using atelocollagen: its use in cancer therapeutics targeted at the heparin-binding growth factor midkine. Invited
Takei, Y., Kadomatsu, K.
Gene Ther. Mol. Biol. Vol. 9 page: 257-264 2005
Midkine expression in rat spinal motor neurons following sciatic nerve injury. Reviewed
Sakakima, H., Yoshida, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S., Muramatsu, T.
Brain Res. Dev. Brain Res. Vol. 153 ( 2 ) page: 251-260 2004.11
Effects of flanking genes on the phenotypes of mice deficient in basigin/CD147. Reviewed
Chen, S., Kadomatsu, K., Kondo, M., Toyama, Y., Toshimori, K., Ueno, S., Miyake, Y., Muramatsu, T.
Biochem. Biophys. Res. Commun. Vol. 324 ( 1 ) page: 147-153 2004.11
Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage. Reviewed
Kawai, H., Sato, W., Yuzawa, Y., Kosugi, T., Matsuo, S., Takei, Y., Kadomatsu, K., Muramatsu, T.
Am. J. Pathol. Vol. 165 ( 5 ) page: 1603-1612 2004.11
N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing. Reviewed
Uchimura, K., Kadomatsu, K., El-Fasakhany, F.M., Singer, M.S., Izawa, M., Kannagi, R., Takeda, N., Rosen, S.D., Muramatsu, T.
J. Biol. Chem. Vol. 279 ( 33 ) page: 35001-35008 2004.8
Midkine promoter-driven suicide gene expression and -mediated adenovirus replication produced cytotoxic effects to immortalised and tumour cells. Reviewed
Yu, L., Hamada, K., Namba, M., Kadomatsu, K., Muramatsu, T., Matsubara, S., Tagawa, M.
Eur. J. Cancer Vol. 40 ( 11 ) page: 1787-1794 2004.7
Basigin expression and regulation in mouse ovary during the sexual maturation and development of corpus luteum. Reviewed
Chang, H., Ni, H., Ma, X.H., Xu, L.B., Kadomatsu, K., Muramatsu, T., Yang, Z.M.
Mol. Reprod. Dev. Vol. 68 ( 2 ) page: 135-141 2004.6
A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. Reviewed
Takei, Y., Kadomatsu, K., Yuzawa, Y., Matsuo, S, Muramatsu, T.
Cancer Res. Vol. 64 ( 10 ) page: 3365-3370 2004.5
Proteasomal degradation of the nuclear targeting growth factor midkine. Reviewed
Suzuki, N., Shibata, Y., Urano, T., Murohara, T., Muramatsu, T., Kadomatsu, K.
J. Biol. Chem. Vol. 279 ( 17 ) page: 17785-17791 2004.4
Expression of glucose transporter 4 (GLUT4) in the human pancreatic islet of Langerhans. Reviewed
Kobayashi, H., Mitsui, T., Nomura, S., Ohno, Y., Kadomatsu, K., Muramatsu, T., Nagasaka, T., Mizutani, S.
Biochem. Biophys. Res. Commun. Vol. 314 ( 4 ) page: 1121-1125 2004.2
Midkine and pleiotrophin in neural development and cancer. Invited
Kadomatsu, K., Muramatsu, T.
Cancer Lett. Vol. 204 ( 2 ) page: 127-143 2004.2
Insertion of an exogenous promoter in the E1A regulatory region of adenovirus does not disturb viral replication despite reduced E1A transcription. Reviewed
Yu, L., Hamada, K., Namba, M., Kadomatsu, K., Muramatsu, T., Matsubara, S., Tagawa, M.
Cancer Lett. Vol. 203 ( 1 ) page: 51-57 2004.1
Tissue distribution of placental leucine aminopeptidase/oxytocinase during mouse pregnancy. Reviewed
Kobayashi, H., Nomura, S., Mitsui, T., Ito. T., Kuno, N., Ohno, Y., Kadomatsu, K., Muramatsu, T., Nagasaka, T., Mizutani, S.
J. Histochem. Cytochem. Vol. 52 ( 1 ) page: 113-121 2004.1
Ovarian mature cystic teratoma with a highly differentiated homunculus: a case report. Reviewed
Kuno, N., Kadomatsu, K., Nakamura, M., Miwa-Fukuchi, T., Hirabayashi, N., Ishizuka, T.
Birth Defect. Res. Part A Clin. Mol. Teratol. Vol. 70 ( 1 ) page: 40-46 2004.1
Midkine promoter can mediate transcriptional activation of a fused suicide gene in a broader range of human breast cancer compared with c-erbB-2 promoter. Reviewed
Yu, L., Yamamoto, N., Kadomatsu, K., Muramatsu, T., Matsubara, .S, Sakiyama, S., Tagawa, M.
Oncology Vol. 66 ( 2 ) page: 143-149 2004
Expression of basigin, a member of the immunoglobulin superfamily, in the mouse cochlea. Reviewed
Kawano H, Tono T, Kadomatsu K, Muramatsu T, Komune S.
Otorhinolaryngol. Relat. Spec. Vol. 65 ( 6 ) page: 327-331 2003.11
A promoter region of the midkine gene that is frequently expressed in human hepatocellular carcinoma can activate a suicide gene as effectively as the alpha-fetoprotein promoter. Reviewed
Tomizawa M, Yu L, Wada A, Tamaoki T, Kadomatsu K, Muramatsu T, Matsubara S, Watanabe K, Ebara M, Saisho H, Sakiyama S, Tagawa M.
Br. J. Cancer Vol. 89 ( 6 ) page: 1086-1090 2003.9
Cell growth- and P53-dependent transcriptional activity of the midkine promoter confers suicide gene expression in tumor cells. Reviewed
Yu L, Ugai S, O-Wang J, Namba M, Kadomatsu K, Muramatsu T, Matsubara S, Sakiyama S, Tagawa M.
Oncol. Rep. Vol. 10 ( 5 ) page: 1301-1305 2003.9
Preoperative serum midkine concentration is a prognostic marker for esophageal squamous cell carcinoma. Reviewed
Shimada H, Nabeya Y, Tagawa M, Okazumi S, Matsubara H, Kadomatsu K, Muramatsu T, Ikematsu S, Sakuma S, Ochiai T.
Cancer Sci. Vol. 94 ( 7 ) page: 628-632 2003.7
High levels of urinary midkine in various cancer patients. Reviewed
Ikematsu S, Okamoto K, Yoshida Y, Oda M, Sugano-Nagano H, Ashida K, Kumai H, Kadomatsu K, Muramatsu H, Takashi Muramatsu, Sakuma S.
Biochem. Biophys. Res. Commun. Vol. 306 ( 2 ) page: 329-332 2003.6
Correlation of elevated level of blood midkine with poor prognostic factors of human neuroblastomas. Reviewed
Ikematsu S, Nakagawara A, Nakamura Y, Sakuma S, Wakai K, Muramatsu T, Kadomatsu K.
Br. J. Cancer Vol. 88 ( 10 ) page: 1522-1526 2003.5
Increased basigin in bleomycin-induced lung injury. Reviewed
Betsuyaku T, Kadomatsu K, Griffin GL, Muramatsu T, Senior RM.
Am. J. Respir. Cell Mol. Biol. Vol. 28 ( 5 ) page: 600-606 2003.5
Increased serum midkine concentration as a possible tumor marker in patients with superficial esophageal cancer. Reviewed
Shimada H, Nabeya Y, Okazumi S, Matsubara H, Kadomatsu K, Muramatsu T, Ikematsu S, Sakuma S, Ochiai T.
Oncol. Rep. Vol. 10 ( 2 ) page: 411-414 2003.3
Utilization of the promoter region of the midkine gene as a tool to drive therapeutic genes in a tumor specific manner. Reviewed
Sakiyama S, Yu L, Tomizawa M, Shimada H, Kadomatsu K, Muramatsu T, Ikematsu S, Nakagawara A, Tagawa M.
Adv. Enzyme Regul. Vol. 43 page: 57-66 2003
Nuclear targeting by the growth factor midkine. Reviewed
Shibata, Y., Muramatsu, T., Hirai, M., Inui, T., Kimura, T., Saito, H., Lynn M. McCormick, L.M., Bu, G., Kadomatsu, K.,
Mol. Cell Biol. Vol. 22 ( 19 ) page: 6788-6796 2002.10
Basigin expression and hormonal regulation in mouse uterus during the peri-implantation period. Reviewed
Xiao LJ, Chang H, Ding NZ, Ni H, Kadomatsu K, Yang ZM.
Mol. Reprod. Dev. Vol. 63 ( 1 ) page: 47-54 2002.9
Basigin expression and hormonal regulation in the rat uterus during the peri-implantation period. Reviewed
Xiao LJ, Diao HL, Ma XH, Ding NZ, Kadomatsu K, Muramatsu T, Yang ZM.
Reproduction Vol. 124 ( 2 ) page: 219-225 2002.8
Reduction of alpha-galactosyl xenoantigen by expression of endo-beta-galactosidase C in pig endothelial cells. Reviewed
Ogawa H, Kobayashi T, Yokoyama I, Nagatani N, Mizuno M, Yoshida J, Kadomatsu K, Muramatsu H, Nakao A, Muramatsu T.
Xenotransplantation Vol. 9 ( 4 ) page: 290-296 2002.7
5'-,3'-inverted thymidine-modified antisense oligodeoxynucleotide targeting midkine. Its design and application for cancer therapy. Reviewed
Takei Y, Kadomatsu K, Itoh H, Sato W, Nakazawa K, Kubota S, Muramatsu T.
J. Biol. Chem. Vol. 277 ( 6 ) page: 23800-23806 2002.6
Enzymatic removal of alphaGal antigen in pig kidneys by ex vivo and in vivo administration of endo-beta-galactosidase C. Reviewed
Liu D, Kobayashi T, Yokoyama I, Ogawa H, Nagasaka T, Muramatsu H, Kadomatsu K, Oikawa T, Shimano Y, Morozumi K, Uchida K, Muramatsu T, Nakao A.
Xenotransplantation Vol. 9 ( 3 ) page: 228-236 2002.5
Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice. Reviewed
Yanada M, Kojima T, Ishiguro K, Nakayama Y, Yamamoto K, Matsushita T, Kadomatsu K, Nishimura M, Muramatsu T, Saito H.
Blood Vol. 99 ( 7 ) page: 2455-2458 2002.4
Midkine expression is associated with postnatal development of the lungs. Reviewed
Matsuura O, Kadomatsu K, Takei Y, Uchimura K, Mimura S, Watanabe K, Muramatsu T.
Cell Struct. Funct. Vol. 27 ( 2 ) page: 109-115 2002.4
Behaviour of a sperm surface transmembrane glycoprotein basigin during epididymal maturation and its role in fertilization in mice. Reviewed
Saxena DK, Oh-Oka T, Kadomatsu K, Muramatsu T, Toshimori K.
Reproduction Vol. 123 ( 3 ) page: 435-444 2002.3
Functional analysis of the chondroitin 6-sulfotransferase gene in relation to lymphocyte subpopulations, brain development and oversulfated chondroitin sulfates. Reviewed
Uchimura, K., Kadomatsu, K., Nishimura, H., Muramatsu, H., Nakamura, E., Kurosawa, N., Habuchi, O., El-Fasakhany, F.M., Yoshikai, Y., Muramatsu, T.
J. Biol. Chem. Vol. 277 ( 2 ) page: 1443-1450 2002.1
A promoter region of midkine gene can activate transcription of an exogenous suicide gene in human pancreatic cancer. Reviewed
Yoshida Y, Tomizawa M, Bahar R, Miyauchi M, Yamaguchi T, Saisho H, Kadomatsu K, Muramatsu T, Matsubara S, Sakiyama S, Tagawa M.
Anticancer Res. Vol. 22 ( 1A ) page: 117-120 2002.1
Midkine expression in the course of nephrogenesis and its role in ischaemic reperfusion injury. Reviewed
Sato W, Yuzawa Y, Kadomatsu K, Tayasu T, Muramatsu H, Muramatsu T, Matsuo S.
Nephrol. Dial. Transplant. Vol. 9 page: 52-54 2002
Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice. Reviewed
Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Iwase M, Yoshikai Y, Yanada M, Yamamoto K, Matsushita T, Nishimura M, Kusugami K, Saito H, Muramatsu T.
J. Biol. Chem. Vol. 276 ( 50 ) page: 47483-47488 2001.12
Antisense oligodeoxynucleotide targeted to Midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells. Reviewed
Takei Y, Kadomatsu K, Matsuo S, Itoh H, Nakazawa K, Kubota S, Muramatsu T.
Cancer Res. Vol. 61 ( 23 ) page: 8486-8491 2001.12
Expression of midkine in the cochlea. Reviewed
Jia XQ, Nakashima T, Kadomatsu K, Muramatsu T.
Hearing Res. Vol. 160 ( 1-2 ) page: 10-14 2001.10
Midkine is involved in neutrophil infiltration into the tubulointerstitium in ischemic renal injury. Reviewed
Sato W, Kadomatsu K, Yuzawa Y, Muramatsu H, Hotta N, Matsuo S, Muramatsu T.
J. Immunol. Vol. 167 ( 6 ) page: 3463-3469 2001.9
Glypican-2 binds to midkine: the role of glypican-2 in neuronal cell adhesion and neurite outgrowth. Reviewed
Kurosawa N, Chen GY, Kadomatsu K, Ikematsu S, Sakuma S, Muramatsu T.
Glycoconj. J. Vol. 18 ( 6 ) page: 499-507. 2001.6
Haptotactic migration induced by midkine: Involvement of protein-tyrosine phosphatase z, mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Reviewed
Qi, M., Ikematsu, S., Maeda, N., Ichihara-Tanaka, K., Sakuma, S., Noda, M., Muramatsu, T., Kadomatsu, K.
J. Biol. Chem. Vol. 276 ( 19 ) page: 15868-15875 2001.5
Requirement of chondroitin sulfate/dermatan sulfate recognition in midkine-dependent migration of macrophages. Reviewed
Hayashi K, Kadomatsu K, Muramatsu T.
Glycoconj. J. Vol. 18 ( 5 ) page: 401-406 2001.5
Syndecan-4 deficiency increases susceptibility to kappa-carrageenan-induced renal damage. Reviewed
Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Matsuo S, Kusugami K, Saito H, Muramatsu T.
Lab. Invest. Vol. 81 ( 4 ) page: 509-516 2001.4
Retinal degeneration following failed photoreceptor maturation in 5A11/basigin null mice. Reviewed
Ochrietor JD, Moroz TM, Kadomatsu K, Muramatsu T, Linser PJ.
Exp. Eye Res. Vol. 72 ( 4 ) page: 467-477 2001.4
Expression of herpes simplex virus-thymidine kinase gene controlled by a promoter region of the midkine gene confers selective cytotoxicity to ganciclovir in human carcinoma cells. Reviewed
Miyauchi M, Yoshida Y, Tada Y, Narita M, Maeda T, Bahar R, Kadomatsu K, Muramatsu T, Matsubara S, Nakagawara A, Sakiyama S, Tagawa M.
Int. J. Cancer Vol. 91 ( 5 ) page: 723-727 2001.3
Antisense oligonucleotide targeted to midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells. Reviewed
Takei, Y., Kadomatsu, K., Matsuo, S., Itoh, H., Nakazawa, K., Kubota, S., Muramatsu, T.,
Cancer Res. Vol. 61 page: 8486-8491 2001
Syndecan-4 deficiency impairs the fetal vessels in the placental labyrinth. Reviewed
Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Nakamura E, Ito M, Nagasaka T, Kobayashi H, Kusugami K, Saito H, Muramatsu T.
Dev. Dyn. Vol. 219 ( 4 ) page: 539-544 2000.12
Midkine inhibits bradykinin-stimulated Ca(2+) signaling and nitric oxide production in endothelial cells. Reviewed
Tran QK, Watanabe H, Le HY, Yang J, Takeuchi K, Kadomatsu K, Muramatsu T, Ohashi K.
Biochem. Biophys. Res. Commun. Vol. 276 ( 3 ) page: 830-836 2000.10
Complete antithrombin deficiency in mice results in embryonic lethality. Reviewed
Ishiguro K, Kojima T, Kadomatsu K, Nakayama Y, Takagi A, Suzuki M, Takeda N, Ito M, Yamamoto K, Matsushita T, Kusugami K, Muramatsu T, Saito H.
J. Clin. Invest. Vol. 106 ( 7 ) page: 873-878 2000.10
Overexpression of midkine in pancreatic duct adenocarcinomas induced by N-Nitrosobis(2-oxopropyl)amine in hamsters and their cell lines. Reviewed
Tsutsumi M, Kadomatsu K, Tsujiuchi T, Sakitani H, Ikematsu S, Kubozoe T, Yoshimoto M, Muramatsu T, Sakuma S, Konishi Y.
Jpn. J. Cancer Res. Vol. 91 ( 10 ) page: 979-986 2000.10
Serum midkine levels are increased in patients with various types of carcinomas. Reviewed
Ikematsu S, Yano A, Aridome K, Kikuchi M, Kumai H, Nagano H, Okamoto K, Oda M, Sakuma S, Aikou T, Muramatsu H, Kadomatsu K, Muramatsu T.
Br. J. Cancer Vol. 83 ( 6 ) page: 701-706 2000.9
Retinal dysfunction in basigin deficiency. Reviewed
Hori K, Katayama N, Kachi S, Kondo M, Kadomatsu K, Usukura J, Muramatsu T, Mori S, Miyake Y.
Invest. Ophthalmol. Vis. Sci. Vol. 41 ( 10 ) page: 3128-3133 2000.9
Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities. Reviewed
Uchimura K, Fasakhany F, Kadomatsu K, Matsukawa T, Yamakawa T, Kurosawa N, Muramatsu T.
Biochem. Biophys. Res. Commun. Vol. 274 ( 2 ) page: 291-296 2000.8
Homo-oligomer formation by basigin, an immunoglobulin superfamily member, via its N-terminal immunoglobulin domain. Reviewed
Yoshida S, Shibata M, Yamamoto S, Hagihara M, Asai N, Takahashi M, Mizutani S, Muramatsu T, Kadomatsu K.
Eur. J. Biochem. Vol. 267 ( 14 ) page: 4372-4380 2000.7
Distinct expression of midkine and pleiotrophin in the spinal cord and placental tissues during early mouse development. Reviewed
Fan QW, Muramatsu T, Kadomatsu K.
Dev. Growth Differ. Vol. 42 ( 2 ) page: 113-119 2000.4
Midkine expression in Reed-Sternberg cells of Hodgkin's disease. Reviewed
Kato H, Watanabe K, Murari M, Isogai C, Kinoshita T, Nagai H, Ohashi H, Nagasaka T, Kadomatsu K, Muramatsu H, Muramatsu T, Saito H, Mori N, Murate T.
Leuk. Lymphoma Vol. 37 ( 3-4 ) page: 415-424 2000.4
Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions. Reviewed
Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Tsuzuki S, Nakamura E, Kusugami K, Saito H, Muramatsu T.
J. Biol. Chem. Vol. 275 ( 8 ) page: 5249-5252 2000.2
Neointima formation in a restenosis model is suppressed in midkine-deficient mice. Reviewed
Horiba, M., Kadomatsu, K., Nakamura, E., Muramatsu, H., Ikematsu, S., Sakuma, S., Hayashi, K., Yuzawa, Y., Matsuo, S., Kuzuya, M., Kaname, T., Hirai, M., Siato, H., Muramatsu, T.
J. Clin. Invest Vol. 105 ( 4 ) page: 489-495 2000.2
Midkine rescues Wilms' tumor cells from cisplatin-induced apoptosis: regulation of Bcl-2 expression by Midkine. Reviewed
Qi M, Ikematsu S, Ichihara-Tanaka K, Sakuma S, Muramatsu T, Kadomatsu K.
J. Biochem. Vol. 127 ( 2 ) page: 269-277 2000.2
Polyadenylation signal facilitates the expression of foreign gene that is driven by an internal promoter located in the reverse orientation to long terminal repeat of retrovirus. Reviewed
Narita M, Takanaga K, Yoshida Y, Kadomatsu K, Muramatsu T, Matsubara S, Hamada H, Goto S, Saisho H, Sakiyama S, Tagawa M.
Anticancer Res. Vol. 20 ( 1A ) page: 279-282 2000.1
Midkine binds specifically to sulfatide the role of sulfatide in cell attachment to midkine-coated surfaces. Reviewed
Kurosawa N, Kadomatsu K, Ikematsu S, Sakuma S, Kimura T, Muramatsu T.
Eu. J. Biochem. Vol. 267 ( 2 ) page: 344-351 2000.1
Genomic organization and promoter activity of embigin, a member of the immunoglobulin superfamily. Reviewed
Tachikui H, Kurosawa N, Kadomatsu K, Muramatsu T.
Gene Vol. 240 ( 2 ) page: 325-332 1999.11
Expression of the midkine gene in human hepatocellular carcinomas. Reviewed
Koide N, Hada H, Shinji T, Ujike K, Hirasaki S, Yumoto Y, Hanafusa T, Kadomatsu K, Muramatsu H, Muramatsu T, Tsuji T.
Hepato-Gastroenterol. Vol. 46 ( 30 ) page: 3189-3196 1999.11
Immunohistochemical analysis of midkine expression in human prostate carcinoma. Reviewed
Konishi N, Nakamura M, Nakaoka S, Hiasa Y, Cho M, Uemura H, Hirao Y, Muramatsu T, Kadomatsu K.
Oncology Vol. 57 ( 3 ) page: 253-257 1999.10
Spatially and temporally regulated expression of N-acetylglucosamine-6-O-sulfotransferase during mouse embryogenesis. Reviewed
Fan QW, Uchimura K, Yuzawa Y, Matsuo S, Mitsuoka C, Kannagi R, Muramatsu H, Kadomatsu K, Muramatsu T.
Glycobiology Vol. 9 ( 9 ) page: 947-955 1999.9
Determination of the optimal time and dosage of all-trans retinoic acid for induction of murine exencephaly. Reviewed
Kuno N, Kadomatsu K, Muramatsu T.
Teratology Vol. 60 ( 2 ) page: 63-67 1999.8
Syndecan-4 expression is associated with follicular atresia in mouse ovary. Reviewed
Ishiguro K, Kojima T, Taguchi O, Saito H, Muramatsu T, Kadomatsu K.
Histochem. Cell Biol. Vol. 112 ( 1 ) page: 25-33 1999.7
Histological characterization of defective spermatogenesis in mice lacking the basigin gene. Reviewed
Toyama Y, Maekawa M, Kadomatsu K, Miyauchi T, Muramatsu T, Yuasa S.
Anat. Histol. Embryol. Vol. 28 ( 3 ) page: 205-213 1999.7
A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta. Reviewed
Maeda N, Ichihara-Tanaka K, Kimura T, Kadomatsu K, Muramatsu T, Noda M.
J. Biol. Chem. Vol. 274 ( 18 ) page: 12474-12479 1999.4
Frequent expression of midkine gene in esophageal cancer suggests a potential usage of its promoter for suicide gene therapy. Reviewed
Miyauchi M, Shimada H, Kadomatsu K, Muramatsu T, Matsubara S, Ikematsu S, Takenaga K, Asano T, Ochiai T, Sakiyama S, Tagawa M.
Jpn. J. Cancer Res. Vol. 90 ( 4 ) page: 469-475 1999.4
Overexpression of midkine in lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats and its increase with progression. Reviewed
Sakitani H, Tsutsumi M, Kadomatsu K, Ikematsu S, Takahama M, Iki K, Tsujiuchi T, Muramatsu T, Sakuma S, Sakaki T, Konishi Y.
Carcinogenesis Vol. 20 ( 3 ) page: 465-469 1999.3
Levels of expression of pleiotrophin and protein tyrosine phosphatase zeta are decreased in human colorectal cancers. Reviewed
Yamakawa T, Kurosawa N, Kadomatsu K, Matsui T, Itoh K, Maeda N, Noda M, Muramatsu T.
Cancer Lett. Vol. 135 ( 1 ) page: 91-96 1999.1
Expression of midkine in the early stage of carcinogenesis in human colorectal cancer. Reviewed
Ye C, Qi M, Fan QW, Ito K, Akiyama S, Kasai Y, Matsuyama M, Muramatsu T, Kadomatsu K.
Br. J. Cancer Vol. 79 ( 1 ) page: 179-184 1999.1
Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour. Reviewed
Nakamura E, Kadomatsu K, Yuasa S, Muramatsu H, Mamiya T, Nabeshima T, Fan QW, Ishiguro K, Igakura T, Matsubara S, Kaname T, Horiba M, Saito H, Muramatsu T.
Genes Cells Vol. 3 ( 12 ) page: 811-822 1998.12
Stage-specific localization of basigin, a member of the immunoglobulin superfamily, during mouse spermatogenesis. Reviewed
Maekawa M, Suzuki-Toyota F, Toyama Y, Kadomatsu K, Hagihara M, Kuno N, Muramatsu T, Dohmae K, Yuasa S.
Arch. Histol. Cytol. Vol. 61 ( 5 ) page: 405-415 1998.12
Human N-acetylglucosamine-6-O-sulfotransferase involved in the biosynthesis of 6-sulfo sialyl Lewis X: molecular cloning, chromosomal mapping, and expression in various organs and tumor cells. Reviewed
Uchimura K, Muramatsu H, Kaname T, Ogawa H, Yamakawa T, Fan QW, Mitsuoka C, Kannagi R, Habuchi O, Yokoyama I, Yamamura K, Ozaki T, Nakagawara A, Kadomatsu K, Muramatsu T.
J. Biochem. Vol. 124 ( 3 ) page: 670-678 1998.9
Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase. Reviewed
Uchimura K, Muramatsu H, Kadomatsu K, Fan QW, Kurosawa N, Mitsuoka C, Kannagi R, Habuchi O, Muramatsu T.
J. Biol. Chem. Vol. 273 ( 35 ) page: 22577-22583 1998.8
Truncated midkine as a marker of diagnosis and detection of nodal metastases in gastrointestinal carcinomas. Reviewed
Aridome K, Takao S, Kaname T, Kadomatsu K, Natsugoe S, Kijima F, Aikou T, Muramatsu T.
Br. J. Cancer Vol. 78 ( 4 ) page: 472-477 1998.8
Clusters of basic amino acids in midkine: roles in neurite-promoting activity and plasminogen activator-enhancing activity. Reviewed
Akhter S, Ichihara-Tanaka K, Kojima S, Muramatsu H, Inui T, Kimura T, Kaneda N, Talukder AH, Kadomatsu K, Inagaki F, Muramatsu T.
J. Biochem. Vol. 123 ( 6 ) page: 1127-1136 1998.6
Embigin/basigin subgroup of the immunoglobulin superfamily: different modes of expression during mouse embryogenesis and correlated expression with carbohydrate antigenic markers. Reviewed
Fan QW, Kadomatsu K, Uchimura K, Muramatsu T.
Dev. Growth Differ. Vol. 40 ( 3 ) page: 277-286 1998.6
Porcine alpha-1,3-galactosyltransferase: full length cDNA cloning, genomic organization, and analysis of splicing variants. Reviewed
Katayama A, Ogawa H, Kadomatsu K, Kurosawa N, Kobayashi T, Kaneda N, Uchimura K, Yokoyama I, Muramatsu T, Takagi H.
Glycoconjugate J. Vol. 15 ( 6 ) page: 583-589 1998.6
Mouse chondroitin 6-sulfotransferase: molecular cloning, characterization and chromosomal mapping. Reviewed
Uchimura K, Kadomatsu K, Fan QW, Muramatsu H, Kurosawa N, Kaname T, Yamamura K, Fukuta M, Habuchi O, Muramatsu T.
Glycobiology Vol. 8 ( 5 ) page: 489-496 1998.5
Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Reviewed
Kuno N, Kadomatsu K, Fan QW, Hagihara M, Senda T, Mizutani S, Muramatsu T.
FEBS Lett. Vol. 425 ( 2 ) page: 191-194 1998.3
A null mutation in basigin, an immunoglobulin superfamily member, indicates its important roles in peri-implantation development and spermatogenesis. Reviewed
Igakura, T., Kadomatsu, K., Kaname, T., Muramatsu, H., Fan, Q.-W., Miyauchi, T., Toyama, Y., Kuno, N., Yuasa, S., Takahashi, M., Senda, M., Taguchi, O., Yamamura, K., Arimura, K., Muramatsu, T.,
Dev. Biol. Vol. 194 ( 2 ) page: 152-165 1998.2
Functional modules and expression of mouse p40(phox) and p67(phox), SH3-domain-containing proteins involved in the phagocyte NADPH oxidase complex. Reviewed
Mizuki K, Kadomatsu K, Hata K, Ito T, Fan QW, Kage Y, Fukumaki Y, Sakaki Y, Takeshige K, Sumimoto H.
Eur. J. Biochem. Vol. 251 ( 3 ) page: 573-582 1998.2
Midkine counteracts the activin signal in mesoderm induction and promotes neural formation. Reviewed
Yokota C, Takahashi S, Eisaki A, Asashima M, Akhter S, Muramatsu T, Kadomatsu K.
J. Biochem. Vol. 123 ( 2 ) page: 339-346 1998.2
Midkine expression in transient retinal ischemia in the rat. Reviewed
Miyashiro M, Kadomatsu K, Ogata N, Yamamoto C, Takahashi K, Uyama M, Muramatsu H, Muramatsu T.
Curr. Eye Res. Vol. 17 ( 1 ) page: 9-13 1998.1
Expression of basigin, a member of the immunoglobulin superfamily, in the mouse central nervous system. Reviewed
Fan QW, Yuasa S, Kuno N, Senda T, Kobayashi M, Muramatsu T, Kadomatsu K.
Neurosci. Res. Vol. 30 ( 1 ) page: 53-63 1998.1
Increased expression of midkine during the progression of human astrocytomas. Reviewed
Mishima K, Asai A, Kadomatsu K, Ino Y, Nomura K, Narita Y, Muramatsu T, Kirino T.
Neurosci. Lett. Vol. 233 ( 1 ) page: 29-32 1997.9
Expression of midkine and pleiotropin in ovarian tumors. Reviewed
Nakanishi T, Kadomatsu K, Okamoto T, Tomoda Y, Muramatsu T.
Obstet. Gynecol. Vol. 90 ( 2 ) page: 285-290 1997.8
Abnormalities of sensory and memory functions in mice lacking Bsg gene. Reviewed
Naruhashi K, Kadomatsu K, Igakura T, Fan QW, Kuno N, Muramatsu H, Miyauchi T, Hasegawa T, Itoh A, Muramatsu T, Nabeshima T.
Biochem. Biophys. Res. Commun. Vol. 236 ( 3 ) page: 733-737 1997.7
Expression of the retinoid-inducible polypeptide, midkine, in human epidermal keratinocytes. Reviewed
Inazumi T, Tajima S, Nishikawa T, Kadomatsu K, Muramatsu H, Muramatsu T.
Arch. Dermatol. Res. Vol. 289 ( 8 ) page: 471–475 1997.7
Dimerization of midkine by tissue transglutaminase and its functional implication. Reviewed
Kojima S, Inui T, Muramatsu H, Suzuki Y, Kadomatsu K, Yoshizawa M, Hirose S, Kimura T, Sakakibara S, Muramatsu T.
J. Biol. Chem. Vol. 272 ( 14 ) page: 9410-9416 1997.4
Direct gene replacement of the mouse Alpha(1,3)-galactosyltransferase gene with human Alpha(1,2)-fucosyltransferase gene: converting Alpha-galactosyl epitopes into H antigens. Reviewed
Chihiro Koike, Akio Katayama, Kenji Kadomatsu, Takashi Muramatsu, Nozomu Hiraiwa, Reiji Kannagi, Izumi Nakashima, Itsuo Yokoyama, Hiroshi Takagi.
Xenotransplantation Vol. 4 page: 147-153 1997.4
Le(X) structure enhances myocardial differentiation from embryonic stem cells. Reviewed
Sudou A, Muramatsu H, Kaname T, Kadomatsu K, Muramatsu T.
Cell Struct. Funct. Vol. 22 ( 2 ) page: 247-251 1997.4
alpha-Galactosyl oligosaccharides conjugated with polyethylene glycol as potential inhibitors of hyperacute rejection upon xenotransplantation. Reviewed
Nagasaka T, Kobayashi T, Muramatsu H, Fujimoto H, Matsuo I, Ajisaka K, Kadomatsu K, Hayashi S, Yokoyama I, Hayakawa A, Muramatsu T, Takagi H.
Biochem. Biophys. Res. Commun. Vol. 232 ( 3 ) page: 731-736 1997.3
Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine. Reviewed
Nakanishi T, Kadomatsu K, Okamoto T, Ichihara-Tanaka K, Kojima T, Saito H, Tomoda Y, Muramatsu T.
J. Biochem. Vol. 121 ( 2 ) page: 197-205 1997.2
Alteration of midkine expression associated with chemically-induced differentiation in human neuroblastoma cells. Reviewed
Koshizawa SH, Matsumura T, Kadono Y, Sawada T, Kadomatsu K, Muramatsu H, Muramatsu T.
Cancer Lett. Vol. 111 ( 1-2 ) page: 117-125 1997.1
Midkine induces the transformation of NIH3T3 cells. Reviewed
Kadomatsu K, Hagihara M, Akhter S, Fan QW, Muramatsu H, Muramatsu T.
Br. J. Cancer Vol. 75 ( 3 ) page: 354-359 1997
Regulation of apoptosis induced by TGF-b1 in non-tumorigenic and tumorigenic rat prostatic epithelial cell lines. Reviewed
Kadomatsu, K., Hsing, A.Y., Bonham, M.J., Danielpour, D.
Cancer Res. Vol. 56 ( 22 ) page: 5146-5149 1996.11
Regulation of apoptosis induced by transforming growth factor-beta1 in nontumorigenic rat prostatic epithelial cell lines. Reviewed
Hsing AY, Kadomatsu K, Bonham MJ, Danielpour D.
Cancer Res. Vol. 56 ( 22 ) page: 5146-5149 1996.11
Roles of basigin, a member of the immunoglobulin superfamily, in behavior as to an irritating odor, lymphocyte response, and blood-brain barrier. Reviewed
Igakura T, Kadomatsu K, Taguchi O, Muramatsu H, Kaname T, Miyauchi T, Yamamura K, Arimura K, Muramatsu T.
Biochem. Biophys. Res. Commun. Vol. 224 ( 1 ) page: 33-36 1996.7
Enzyme-linked immunoassay for midkine, and its application to evaluation of midkine levels in developing mouse brain and sera from patients with hepatocellular carcinomas. Reviewed
Muramatsu H, Song XJ, Koide N, Hada H, Tsuji T, Kadomatsu K, Inui T, Kimura T, Sakakibara S, Muramatsu T.
J. Biochem. Vol. 119 ( 6 ) page: 1171-1175 1996.6
The expression of truncated MK in human tumors. Reviewed
Kaname T, Kadomatsu K, Aridome K, Yamashita S, Sakamoto K, Ogawa M, Muramatsu T, Yamamura K.
Biochem. Biophys. Res. Commun. Vol. 219 ( 1 ) page: 256-260 1996.2
Intoroduction of Alpha(1,2) fucosyltransferase and its effect on Alpha-Gal epitopes in transgenic pig. Reviewed
Chihiro Koike, Reiji Kannagi, Yoshihiro Takuma, Fumiko Akutsu, Satoshi Hayashi, Nozomu Hiraiwa, Kenji Kadomatsu, Takashi Muramatsu, Hirohito Yamakawa, Takuya Nagai, Shoji Kobayashi, Hidechika Okada, Izumi Nakashima, Kazuharu Uchida, Itsuo Yokoyama, Hiroshi Takagi.
Xenotransplantation Vol. 3 page: 81-86 1996
Increased midkine gene expression in human gastrointestinal cancers. Reviewed
Aridome, K., Tsutsui, J., Takao, S., Kadomatsu, K., Ozawa, M., Aikou, T., Muramatsu, T.
Jpn. J. Cancer Res. Vol. 86 ( 7 ) page: 655-661 1995.7
Restricted expression of Xenopus midkine gene during early development. Reviewed
Sekiguchi K, Yokota C, Asashima M, Kaname T, Fan QW, Muramatsu T, Kadomatsu K.
J. Biochem. Vol. 118 ( 1 ) page: 94-100 1995.7
Development and characterization of nontumorigenic and tumorigenic epithelial cell lines from rat dorsal-lateral prostate. Reviewed
Danielpour, D., Kadomatsu, K., Anzano, M.A., Smith, J.M., Sporn, M.B.
Cancer Res. Vol. 54 ( 13 ) page: 3413-3421 1994.7
Histogenesis of induced prostate carcinoma in Lobund-Wistar rats : A model system for histologic scoring and grading. Reviewed
Slayter, M.V., Anzano, M.A., Kadomatsu, K., Sporn, M.B., Smith, J.
Cancer Res. Vol. 54 ( 6 ) page: 1440-1445 1994.3
Expression of sulfated glycoprotein 2 is associated with carcinogenesis induced by N-nitroso-N-methylurea in rat prostate and seminal vesicle. Reviewed
Kadomatsu, K., Anzano, M.A., Slayter, M.V., Winokur, T.S., Smith, J.M., Sporn, M.B.
Cancer Res. Vol. 53 ( 7 ) page: 1480-1483 1993.4
A new family of heparin-binding growth differentiation factors : Increased midkine expression in Wilms' tumor and other human carcinomas. Reviewed
Tsutsui, J., Kadomatsu, K., Matsubara, S., Nakagawara, A., Hamanoue, M., Takao, S., Shimazu, H., Ohi, Y., Muramatsu, T.
Cancer Res. Vol. 53 ( 6 ) page: 1281-1285 1993.3
Embigin, a member of the immunoglobulin superfamily expressed in embryonic cells, enhances cell-substratum adhesion. Reviewed
Huang, R.-P., Ozawa, M., Kadomatsu, K. Muramatsu, T.
Dev. Biol. Vol. 155 ( 2 ) page: 307-314 1993.2
Genomic structure of human midkine (MK), a retinoic acid-responsive growth/differentiation factor. Reviewed
Uehara, K., Matsubara, S., Kadomatsu, K., Tsutsui, J., Muramatsu, T.
J. Biochem. Vol. 111 ( 5 ) page: 563-567 1992.5
Undifferentiated (embryonal) sarcoma of the liver : Report of three cases.
Kadomatsu, K., Nakagawara, A., Zaizen, Y., Nagoshi, M., Tsuneyoshi, M., Fukushige, T., Haigo, A., Suita, S.
Surg.Today Vol. 22 ( 5 ) page: 451-455 1992
A new family of heparin-binding factors : Strong conservation of midkine (MK) sequences between the human and the mouse. Reviewed
Tsutsui, J., Uehara, K., Kadomatsu, K., Matsubara, S., Muramatsu, T.
Biochem. Biophys. Res. Commun. Vol. 176 ( 2 ) page: 792-797 1991.4
Inverse expression of MYCN and MDR-1 in human neuroblastoma. Reviewed
Nakagawara, A., Kadomatsu, K., Sato, S., Kohno, K., Takano, H., Kuwano, M.
Prog. Clin. Biol. Res. Vol. 366 page: 11-19 1991
Developmentally regulated expression of embigin, a member of the immunoglobulin superfamily found in embryonal carcinoma cells. Reviewed
Huang, R-P., Ozawa, M., Kadomatsu, K., Muramatsu, T.
Differentiation Vol. 45 ( 2 ) page: 76-83 1990.11
A retinoic acid responsive gene, MK, produces a secreted protein with heparin binding activity. Reviewed
Tomomura, M., Kadomatsu, K., Nakamoto, M., Muramatsu, H., Kondoh, H., Imagawa, K., Muramatsu, T.
Biochem. Biophys. Res. Commun. Vol. 171 ( 2 ) page: 603-609 1990.9
A retinoic acid responsive gene, MK, found in the teratocarcinoma system : Heterogeneity of the transcript and the nature of the translation product. Reviewed
Tomomura, M., Kadomatsu, K., Matsubara, S., Muramatsu, T.
J. Biol. Chem. Vol. 265 ( 18 ) page: 10765-10770 1990.6
Structure of a retinoic acid-responsive gene, MK, which is transiently activated during the differentiation of embryonal carcinoma cells and the mid-gestation period of mouse embryogenesis. Reviewed
Matsubara, S., Tomomura, M., Kadomatsu, K., Muramatsu, T.
J. Biol. Chem. Vol. 265 ( 16 ) page: 9441-9443 1990.6
Inverse correlation between expression of multidrug resistance gene and N-myc oncogene in human neuroblastomas. Reviewed
Nakagawara, A., Kadomatsu, K., Sato, S., Kohno, K., Takano, H., Akazawa, K., Nose, Y., Kuwano, M.
Cancer Res. Vol. 50 ( 10 ) page: 3043-3047 1990.5
*A retinoic acid responsive gene, MK, found in the teratocarcinoma system is expressed in spatially and temporally controlled manner during mouse embyogenesis. Reviewed
Kadomatsu, K., Huang, R-P., Suganuma, T., Murata, F., Muramatsu, T.,
J. Cell Biol. Vol. 110 ( 3 ) page: 607-616 1990.3
Cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis. Reviewed
Kadomatsu, K., Tomomura, M., Muramatsu, T.
Biochem. Biophys. Res. Commun. Vol. 151 ( 3 ) page: 1312-1318 1988.3
「糖鎖生物学」 神経と糖鎖(I)-神経発生と再生
北島健 佐藤ちひろ 門松健治 加藤晃一 ( Role: Sole author)
名古屋大学出版会 2020
Human Glycome Project への世界と日本の動き〜本特集の序に代えて〜
門松健治( Role: Sole author)
生化学 2020
未来を創るグライコサイエンスー我が国のロードマップー
門松健治( Role: Sole author)
2018
医療の明日に応える リレーエッセイ「時間の風景」
門松健治健治( Role: Sole author)
2017.4
サイトカイン・増殖因子キーワード事典・Midkine, Pleiotrophin.
門松健治( Role: Sole author)
羊土社 2015
Sugar Chains. The Involvement of Midkine, a Heparin-Binding Growth Factor, in Cancer Development.
Kishida S and Kadomatsu K.( Role: Sole author)
Springer 2015
Glycoscience: Biology and Medicine. Glycosaminoglycans: Key Regulator for Recovery from Neuronal Injuries.
門松健治( Role: Sole author)
2015
最先端メディカルエンジニアリング・成長因子ミッドカインの作用機構
門松健治( Role: Joint author)
一粒書房 2013.3
Midkine: From Embryogenesis to Pathogenesis and Therapy. Vascular restenosis and midkine.
Kadomatsu K.( Role: Sole author)
Springer 2012
Midkine: From Embryogenesis to Pathogenesis and Therapy. Midkine and heart failure.
Horiba M, Kadomatsu K.( Role: Sole author)
Springer 2012
Midkine: From Embryogenesis to Pathogenesis and Therapy. The potential of MK through the renin-angiotensin system.
Kosugi T, Kadomatsu K.( Role: Sole author)
Springer 2012
Midkine: From Embryogenesis to Pathogenesis and Therapy. Role of midkine in nephrogenesis and kidney disease.
Sato W, Kadomatsu K.( Role: Sole author)
Springer 2012
Midkine: From Embryogenesis to Pathogenesis and Therapy. Midkine and chemoresistance in cancers.
Takei Y, Kadomatsu K.( Role: Sole author)
Springer 2012
Experimental Glycoscience. The Midkine Family and Its Receptors.
Kadomatsu, K.( Role: Sole author)
Springer 2008
Neural Proteoglycans. Keratan sulfate and gliosis.
Kadomatsu, K.( Role: Sole author)
Research Signpost 2007
糖鎖科学の新展開 機能解明・次世代型材料・医薬品開発に向けて・ミッドカインファミリー
門松健治( Role: Sole author)
2005
心臓ナビゲーター・ミッドカイン
門松健治、林健司( Role: Sole author)
メディカルレビュー社 2004
医学大辞典・ビタミンAその他
門松健治( Role: Sole author)
医学書院 2003
Vascular Biology ナビゲーター・ミッドカイン
門松健治( Role: Sole author)
メディカルレビュー社 2001
月刊がん9月「研究最前線」・がん研究レポート ミッドカインはヒトのガン組織で大量に産生される
門松健治( Role: Sole author)
日本医療情報出版 2000
月刊がん10月「研究最前線」・がん研究レポート 腫瘍マーカー、分子標的としての脚光を浴びるミッドカイン
門松健治( Role: Sole author)
日本医療情報出版 2000
わかりやすい分子生物学・核受容体とステロイドホルモンの作用機構
門松健治( Role: Sole author)
丸善株式会社 1999
ティシュエンジニアリング-組織工学の基礎と応用・クローン技術と異種臓器移植
小林孝彰、小川晴子、長坂隆治、林衆治、横山逸男、中尾昭公、佐藤英明、三好和睦、門松健治、村松喬、高木弘( Role: Joint author)
名古屋大学出版会 1999
わかりやすい分子生物学・細胞の死
門松健治( Role: Sole author)
丸善株式会社 1999
BioScience用語ライブラリー・MidkineとPleiotrophin
門松健治( Role: Sole author)
羊土社 1998
細胞工学:グライコバイオロジー実験プロトコール・ミッドカイン-cDNA導入による細胞機能の改変-
門松健治( Role: Sole author)
秀潤社 1996
傷ついた神経はなぜ再生しないのか
門松健治
第11回 形態科学シンポジウム 2019.10.22
学会誌JBの試み
門松健治
第92回 日本生化学会大会
Proteoglycans in axon regeneration and neural plasticity. Invited International conference
Kadomatsu K.
Iubm2018
Midkine promotes NFAT regulated T-cell activation & Th1 differentiation in lupus nephritis. Invited International conference
Kadomatsu K.
Fifth Midkine Symposium
Midkine in atherosclerotic plaque formation. Invited
Kadomatsu K.
Fifth Midkine Symposium
Proteoglycans and neural plasticity. Invited
Kadomatsu K.
Glycosaminoglycans in axon regeneration and neural plasticity. Invited International conference
Kadomatsu K.
Glycans in Neural Plasticity. Invited International conference
Kadomatsu K.
2017 Glyco-retreat
Sulfated glycans regulate autophagy and axon regenetation. Invited International conference
Kadomatsu K.
SfN-Neuroscience2016
Mechanisms of axon regeneration inhibition after neuronal injury. Invited International conference
Kadomatsu K.
Freiburg/Adelaide/Nagoya Annual Symposium
Mechanisms of Axon Regeneration and its Inhibition. Invited International conference
Kadomatsu K.
Fourth Midkine Symposium
Sulfated glycans regulate autophagy and axon regeneration. Invited International conference
Kadomatsu K.
The 3rd International symposium on Glyco-neuroscience
Sulfated glycans regulates autophagy and axon regenetration. Invited International conference
Why should we care about glycans in the brain. Invited International conference
Kadomatsu K.
Society for Glycobiology : Satellite Symposium II Glycans in Neuroscience
Role of Keratan sulfate and chondroitin sulfate in axon regeneration. Invited International conference
Kadomatsu K.
4th ECMNET Conference
Biomedical research at Nagoya University. Invited International conference
Kadomatsu K.
International joint symposium Nagoya University, University of Adelaide, University of Freiburg
Roles of sulfated glycans and autophagy in dystrophic endball formation in the axonal regeneration inhibition. International conference
Kadomatsu K.
International symposium on Glyco-neuroscience
Keratan sulfate and neuronal circuit reconstruction. International conference
Kadomatsu K.
Proteoglycans 2013
A link between two sugar chains, keratan sulfate and chondroitin sulfate, in axonal regeneration/sprouting. International conference
Kadomatsu K.
GCOE International Symposium
Regulation of neural Neuroscienceplasticity by sugar chains-towards integration of glyco- and neuro-biology. International conference
Kadomatsu K.
Neuroscience2012
Midkine: at the intersection of neurobiology and cancer. International conference
Kadomatsu K.
Excellence in midkine research conference(Key Note Lecture)
Neuronal differentiation factor and neuroblastoma development. International conference
Kadomatsu K.
International Symposium on Developmental Biology and Cancer
Proteoglycans and neuronal network reconstruction. International conference
Kadomatsu K.
7th international conference on proteoglycans
Proteoglycans and neuronal network reconstruction. International conference
Kadomatsu K.
Glycobiology Japan-Netherland joint seminar
Keratan sulfate biosynthesis is required for glial scar formation after brain injury. International conference
The 21st century COE program 3rd international symposium
N-Acetylglucosamine 6-O-sulfotransferase mice show loss of keratin sulfate in the brain. International conference
2nd Workshop the Netherlands-Japan Recent Advances in Glycobiology, Utrecht
N-acetylglucosamine-6-O-sulfotransferase-1 deficiency causes loss of keratan sulfate in the developing brain and injured brain. International conference
Glycobiology 14, 1065, 2004. Joint meeting of the Society for glycobiology and the Japanese society of carbohydrate research
Nuclear targeting by the growth factor midkine. International conference
9th World congress on advances in oncology and 7th International symposium on molecular medicine
神経発達および精神機能における成長因子ミッドカインの役割
門松健治
Neuro2004(第27回日本神経科学大会、第47回日本神経化学会大会合同大会)
細胞分裂期キナーゼ阻害にもとづく難治性神経芽腫の新規治療法開発
2017.11
AMED(次世代がん医療創生研究事業)
門松健治
Grant type:Competitive
癌検体の収集、実験データの取得および介入実験
2017.4
CREST
津田宏治
Grant type:Competitive
MYCファミリー遺伝子高発現型がんを標的とした新規治療法開発(先端)
2017.4 - 2019.3
学内共同研究
抗Midkineモノクローナル抗体併用によるシスプラチン腎障害を排した神経芽腫化学療法(先端)
2016.4 - 2018.3
学内共同研究
なぜ遺伝子変異なしでがんができるのか:その分子基盤解明と標的探索
2015.4 - 2017.3
受託研究
沖縄県北部産島野菜の免疫調節機能及び抗腫瘍機能を活用した健康食品及び医薬品の開発・事業化
2015.4 - 2017.3
受託研究
VRK1キナーゼ阻害剤による難治性神経芽腫の治療法開発(先端)
2015.4 - 2017.3
学内共同研究
難治性神経芽種の合成致死治療(先端)
2013.4 - 2016.3
学内共同研究
神経芽腫治療法開発へのモデル動物の応用
2013.4 - 2015.3
受託研究
癌に対するミッドカインRNAアプタマーの研究
2007.4 - 2017.3
国内共同研究
疾患モデルブタの研究開発
2007.4 - 2012.3
特色ある大学教育支援プログラム
Grant type:Competitive
A new ligand for ALK and its activation mechanism
Grant number:19H03415 2019.4 - 2022.3
Authorship:Principal investigator
Grant amount:\17550000 ( Direct Cost: \13500000 、 Indirect Cost:\4050000 )
正常発達逸脱によるがん発生機構
2015.4 - 2017.3
科学研究費補助金 挑戦的萌芽研究
がん自然退縮の制御機構解明
2013.4 - 2015.3
科学研究費補助金 挑戦的萌芽研究
門松健治
Authorship:Principal investigator
生物の化学
2021
生物学基礎I
2021
人体機能学
2021
生物学基礎I
2020
人体機能学
2020
生物学基礎I
2019
生物の化学
2019
人体機能学
2019
生物学基礎Ⅰ
2018
生物の化学
2018
人体機能学
2018
生物学基礎Ⅰ
2017
生物の化学
2017
人体機能学
2017
生物学基礎Ⅰ
2016
生物の化学
2016
基礎セミナーA
2016
人体機能学
2016
生物学基礎Ⅰ
2015
生物の化学
2015
基礎セミナーA
2015
生物学基礎Ⅰ
2014
生物の化学
2014
基礎セミナーA
2014
生物学基礎Ⅰ
2013
生物の化学
2013
基礎セミナーA
2013
生物の化学
2012
基礎セミナーA
2012
生物学基礎Ⅰ
2012
生物学基礎Ⅰ
2011
基礎セミナーA
2011
Bichemistry
2011