Updated on 2025/10/24
博士（医学） （ 2009.9 名古屋大学 ）
耳科学
Life Science / Otorhinolaryngology
The Oto-Rhino-Laryngological Society of Japan
日本耳科学会
日本聴覚医学会
Japan society of equilibrium research
The Society of Practical Otolaryngology
Yoshida, T; Ishino, T; Iwasaki, S; Oishi, N; Matsuda, Y; Tono, T; Sugahara, K; Yamazaki, H; Jitsukawa, S; Nakanishi, H; Kitoh, R; Sato, T; Kobayashi, M; Nishida, K; Nakaichi, T; Bruns, P; Bruns, P; Bruns, P; Bruns, P
PLOS ONE Vol. 20 ( 8 ) page： e0327124 2025.8
Cognitive function and speech outcomes after cochlear implantation in older adults Open Access
Yoshida, T; Kobayashi, M; Hara, D; Taniguchi, R; Fukunaga, Y; Sone, M
FRONTIERS IN NEUROLOGY Vol. 16 page： 1630946 2025.7
Katayama, N; Yoshida, T; Nakashima, T; Kobayashi, M; Suzuki, H; Hamajima, N; Sone, M
NUTRITION AND HEALTH Vol. 31 ( 3 ) page： 915 - 924 2025.7
Microsurgical Robotic System for Myringoplasty: Feasibility Study
Yoshida, T; Kobayashi, M; Okubo, T; Hatayama, N; Otsuka, S; Wakana, K; Owaki, H; Matsuda, Y; Mikami, K; Naito, M
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY Vol. 10 ( 3 ) 2025.6
Naganawa, S; Ito, R; Kawamura, M; Taoka, T; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES 2025.3
Naganawa, S; Ito, R; Kawamura, M; Taoka, T; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES 2025.3
Factors influencing auditory brainstem response changes in infants (vol 185, 112094, 2024)
Esaki, T; Yoshida, T; Kobayashi, M; Morimoto, K; Shibata, C; Sone, M
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY Vol. 190 2025.3
Direct Visualization of Tracer Permeation into the Endolymph in Human Patients Using MR Imaging Open Access
Naganawa, S; Ito, R; Kawamura, M; Taoka, T; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 24 ( 2 ) page： 253 - 261 2025
Factors influencing auditory brainstem response changes in infants Open Access
Esaki, T; Yoshida, T; Kobayashi, M; Morimoto, K; Shibata, C; Sone, M
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY Vol. 185 page： 112094 2024.10
Correlation of Endolysmphatic Duct Signal Intensity With Clinical Features in Otological Diseases Open Access
Matsui, K; Yoshida, T; Sugimoto, S; Kobayashi, M; Naganawa, S; Sone, M
OTOLOGY & NEUROTOLOGY Vol. 45 ( 9 ) page： e624 - e629 2024.10
Perilymphatic enhancement and endolymphatic hydrops: MRI findings and clinical associations
Kobayashi, M; Yoshida, T; Fukunaga, Y; Hara, D; Naganawa, S; Sone, M
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY Vol. 9 ( 5 ) 2024.10
Imaging evaluation and volumetric measurement of the space surrounding the diploic veins
Nakamichi, R; Taoka, T; Ito, R; Yoshida, T; Sone, M; Naganawa, S
JAPANESE JOURNAL OF RADIOLOGY Vol. 42 ( 9 ) page： 953 - 961 2024.9
Possible causes of vertigo attacks in Meniere's disease
Nakashima, T; Naganawa, S; Yoshida, T; Sone, M
MEDICAL HYPOTHESES Vol. 189 2024.8
Efficacy of 100 hz sound stimulation on saccular dysfunction in meniere's disease Open Access
Sone, M; Ohgami, N; Katayama, N; Kobayashi, M; Gu, Y; Tong, K; Yoshida, T; Naganawa, S; Kato, M
ACTA OTO-LARYNGOLOGICA Vol. 144 ( 4 ) page： 272 - 276 2024.4
Clinical significance of posterior expansion of the utricular endolymphatic space Open Access
Kaida, H; Yoshida, T; Sugimoto, S; Kobayashi, M; Naganawa, S; Sone, M
ACTA OTO-LARYNGOLOGICA Vol. 144 ( 2 ) page： 107 - 111 2024.2
Improvement of vertigo symptoms and acoustic power absorbance in cases with endolymphatic hydrops
Kobayashi, M; Yoshida, T; Fukunaga, Y; Hara, D; Sugimoto, S; Naganawa, S; Sone, M
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY Vol. 9 ( 1 ) 2024.2
Naganawa, S; Ito, R; Kawamura, M; Taoka, T; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 23 ( 1 ) page： 80 - 91 2024
Disruption of the Blood-Perilymph Barrier Preceding Endolymphatic Hydrops Formation in Meniere's Disease Open Access
Kobayashi, M; Yoshida, T; Sugimoto, S; Naganawa, S; Sone, M
OTOLOGY & NEUROTOLOGY Vol. 44 ( 10 ) page： E766 - E767 2023.12
Yoshida, T; Hara, D; Kobayashi, M; Sugimoto, S; Fukunaga, Y; Sone, M
OTOLOGY & NEUROTOLOGY Vol. 44 ( 8 ) page： E560 - E565 2023.9
Association between Locomotive Syndrome and Hearing Loss in Community-Dwelling Adults Open Access
Ito, S; Nakashima, H; Segi, N; Ouchida, J; Ishizuka, S; Takegami, Y; Yoshida, T; Hasegawa, Y; Imagama, S
JOURNAL OF CLINICAL MEDICINE Vol. 12 ( 17 ) 2023.9
Fluid signal suppression characteristics of 3D-FLAIR with a T2 selective inversion pulse in the skull base Open Access
Naganawa, S; Kato, Y; Yoshida, T; Sone, M
NATURE COMMUNICATIONS Vol. 14 ( 1 ) page： 4915 2023.8
Comparative Analysis of Cartilage Conduction Hearing Aid Users and Non-Users: An Investigative Study Open Access
Sugimoto, S; Yoshida, T; Fukunaga, Y; Motegi, A; Saito, K; Kobayashi, M; Sone, M
AUDIOLOGY RESEARCH Vol. 13 ( 4 ) page： 563 - 572 2023.8
Kobayashi, M; Katayama, N; Yoshida, T; Sugimoto, S; Naganawa, S; Sone, M
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 85 ( 2 ) page： 375 - 379 2023.5
Sone, M; Kobayashi, M; Yoshida, T; Naganawa, S
FRONTIERS IN NEUROLOGY Vol. 14 2023.4
Katayama, N; Yoshida, T; Nakashima, T; Ito, Y; Teranishi, M; Iwase, T; Sugiura, S; Goto, K; Uchida, Y; Taki, Y; Nakada, T; Tada, A; Suzuki, H; Nakano, Y; Shimono, M; Saji, N; Kogure, A; Shimizu, E; Sone, M; Hamajima, N
FRONTIERS IN PUBLIC HEALTH Vol. 11 2023.4
Yoshida, T; Kobayashi, M; Sugimoto, S; Naganawa, S; Sone, M
AURIS NASUS LARYNX Vol. 50 ( 2 ) page： 299 - 304 2023.4
Presence of endolymphatic hydrops on listening difficulties in patients with normal hearing level
Yoshida, T; Kobayashi, M; Sugimoto, S; Fukunaga, Y; Hara, D; Naganawa, S; Sone, M
ACTA OTO-LARYNGOLOGICA Vol. 143 ( 2 ) page： 163 - 169 2023.2
Impact of endolymphatic hydrops on DPOAE in subjects with normal to mild hearing loss
Inagaki, K; Yoshida, T; Kobayashi, M; Sugimoto, S; Fukunaga, Y; Hara, D; Naganawa, S; Sone, M
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY Vol. 8 ( 1 ) page： 262 - 268 2023.2
Goto, S; Nishio, N; Iwami, K; Yoshida, T; Maruo, T; Mukoyama, N; Tsuzuki, H; Yokoi, S; Wada, A; Hiramatsu, M; Hayashi, Y; Kamei, Y; Fujii, M; Sone, M; Fujimoto, Y
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE Vol. 84 ( 01 ) page： 69 - 78 2023.2
Parasagittal Cystic Lesions May Arise from the Pial Sheath around the Cortical Venous Wall
Naganawa, S; Ito, R; Taoka, T; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 22 ( 1 ) page： 143 - 146 2023
Pitfalls of Using T2-contrast Enhancement Techniques in 3D-FLAIR to Detect Endolymphatic Hydrops
Kato, Y; Naganawa, S; Taoka, T; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 22 ( 3 ) page： 335 - 344 2023
Naganawa, S; Ito, R; Kawamura, M; Taoka, T; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 22 ( 1 ) page： 45 - 55 2023
Yoshida, T; Naganawa, S; Kobayashi, M; Sugimoto, S; Katayama, N; Nakashima, T; Kato, Y; Ichikawa, K; Yamaguchi, H; Nishida, K; Sone, M
FRONTIERS IN NEUROLOGY Vol. 13 page： 1016577 2022.11
Pathological significance and classification of endolymphatic hydrops in otological disorders
Sone, M; Yoshida, T; Sugimoto, S; Kobayashi, M; Teranishi, M; Naganawa, S
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 84 ( 3 ) page： 497 - 505 2022.8
Iwasa, Y; Nishio, S; Yoshimura, H; Sugaya, A; Kataoka, Y; Maeda, Y; Kanda, Y; Nagai, K; Naito, Y; Yamazaki, H; Ikezono, T; Matsuda, H; Nakai, M; Tona, R; Sakurai, Y; Motegi, R; Takeda, H; Kobayashi, M; Kihara, C; Ishino, T; Morita, S; Iwasaki, S; Takahashi, M; Furutate, S; Oka, S; Kubota, T; Arai, Y; Kobayashi, Y; Kikuchi, D; Shintani, T; Ogasawara, N; Honkura, Y; Izumi, S; Hyogo, M; Ninoyu, Y; Suematsu, M; Nakayama, J; Tsuchihashi, N; Okami, M; Sakata, H; Yoshihashi, H; Kobayashi, T; Kumakawa, K; Yoshida, T; Esaki, T; Usami, S
HUMAN GENETICS Vol. 141 ( 3-4 ) page： 865 - 875 2022.4
Iwasa, YI; Nishio, SY; Yoshimura, H; Sugaya, A; Kataoka, Y; Maeda, Y; Kanda, Y; Nagai, K; Naito, Y; Yamazaki, H; Ikezono, T; Matsuda, H; Nakai, M; Tona, R; Sakurai, Y; Motegi, R; Takeda, H; Kobayashi, M; Kihara, C; Ishino, T; Morita, SY; Iwasaki, S; Takahashi, M; Furutate, S; Oka, SI; Kubota, T; Arai, Y; Kobayashi, Y; Kikuchi, D; Shintani, T; Ogasawara, N; Honkura, Y; Izumi, S; Hyogo, M; Ninoyu, Y; Suematsu, M; Nakayama, J; Tsuchihashi, N; Okami, M; Sakata, H; Yoshihashi, H; Kobayashi, T; Kumakawa, K; Yoshida, T; Esaki, T; Usami, SI
HUMAN GENETICS Vol. 141 ( 3-4 ) page： 993 - 995 2022.4
Naganawa, S; Ito, R; Taoka, T; Yoshida, T; Sone, M
RADIOLOGIA MEDICA Vol. 127 ( 4 ) page： 458 - 459 2022.4
Kobayashi, M; Yoshida, T; Uchida, Y; Sugimoto, S; Naganawa, S; Sone, M
OTOLOGY & NEUROTOLOGY Vol. 43 ( 1 ) page： E134 - E136 2022.1
Naganawa, S; Ito, R; Kawai, H; Kawamura, M; Taoka, T; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 21 ( 3 ) page： 459 - 467 2022
MR Imaging of Endolymphatic Hydrops in Five Minutes
Naganawa, S; Ito, R; Kawai, H; Kawamura, M; Taoka, T; Sakai, M; Ichikawa, K; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 21 ( 3 ) page： 401 - 405 2022
Nakamichi, R; Taoka, T; Kawai, H; Yoshida, T; Sone, M; Naganawa, S
JAPANESE JOURNAL OF RADIOLOGY Vol. 39 ( 10 ) page： 927 - 937 2021.10
Facial nerve palsy associated with chronic recurrent multifocal osteomyelitis
Yang, CJ; Yoshida, T; Sugimoto, S; Teranishi, M; Sone, M
PEDIATRICS INTERNATIONAL Vol. 63 ( 9 ) page： 1125 - 1127 2021.9
Nakashima, T; Katayama, N; Saji, N; Teranishi, M; Yoshida, T; Suzuki, H; Sone, M; Hamajima, N
NUTRITION Vol. 89 page： 111268 2021.9
Evaluation of the blood-perilymph barrier in ears with endolymphatic hydrops Open Access
Yoshida, T; Kobayashi, M; Sugimoto, S; Teranishi, M; Naganawa, S; Sone, M
ACTA OTO-LARYNGOLOGICA Vol. 141 ( 8 ) page： 736 - 741 2021.8
Morioka, M; Sugimoto, S; Yoshida, T; Teranishi, M; Kobayashi, M; Nishio, N; Katayama, N; Naganawa, S; Sone, M
OTOLOGY & NEUROTOLOGY Vol. 42 ( 6 ) page： E643 - E647 2021.7
Iwami, K; Fujii, M; Nishio, N; Maruo, T; Yoshida, T; Mukoyama, N; Osuka, K; Takanari, K; Murotani, K; Kamei, Y; Sone, M; Fujimoto, Y; Saito, K
WORLD NEUROSURGERY Vol. 151 page： E192 - E207 2021.7
Cochlear implantation in patient with Charcot-Marie-Tooth disease Open Access
Kobayashi, M; Yoshida, T; Sugimoto, S; Teranishi, M; Hara, D; Kimata, Y; Sone, M
AURIS NASUS LARYNX Vol. 48 ( 2 ) page： 327 - 330 2021.4
Harabuchi, Y; Kishibe, K; Tateyama, K; Morita, Y; Yoshida, N; Okada, M; Kunimoto, Y; Watanabe, T; Inagaki, A; Yoshida, T; Imaizumi, M; Nakamura, T; Matsunobu, T; Kobayashi, S; Iino, Y; Murakami, S; Takahashi, H; Tono, T
AURIS NASUS LARYNX Vol. 48 ( 1 ) page： 2 - 14 2021.2
Lesion-specific prognosis by magnetic resonance imaging in sudden sensorineural hearing loss
Yang, CJ; Yoshida, T; Sugimoto, S; Teranishi, M; Kobayashi, M; Nishio, N; Naganawa, S; Sone, M
ACTA OTO-LARYNGOLOGICA Vol. 141 ( 1 ) page： 5 - 9 2021.1
Naganawa, S; Ito, R; Kato, Y; Kawai, H; Taoka, T; Yoshida, T; Maruyama, K; Murata, K; Körzdörfer, G; Pfeuffer, J; Nittka, M; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 20 ( 1 ) page： 91 - 98 2021
Naganawa, S; Ito, R; Nakamichi, R; Kawamura, M; Taoka, T; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 20 ( 4 ) page： 378 - 384 2021
Naganawa, S; Ito, R; Nakamichi, R; Kawamura, M; Kawai, H; Taoka, T; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 20 ( 3 ) page： 245 - 252 2021
Naganawa, S; Nakamichi, R; Ichikawa, K; Kawamura, M; Kawai, H; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 20 ( 3 ) page： 272 - 279 2021
Morimoto, K; Yoshida, T; Kobayashi, M; Sugimoto, S; Nishio, N; Teranishi, M; Naganawa, S; Sone, M
ACTA OTO-LARYNGOLOGICA Vol. 140 ( 10 ) page： 818 - 822 2020.10
Effects of endolymphatic hydrops on acoustic energy absorbance
Kobayashi, M; Yoshida, T; Sugimoto, S; Shimono, M; Teranishi, M; Naganawa, S; Sone, M
ACTA OTO-LARYNGOLOGICA Vol. 140 ( 8 ) page： 626 - 631 2020.7
Naganawa, S; Ito, R; Kawai, H; Taoka, T; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 19 ( 4 ) page： 375 - 381 2020
Naganawa, S; Ito, R; Taoka, T; Yoshida, T; Sone, M
MAGNETIC RESONANCE IN MEDICAL SCIENCES Vol. 19 ( 1 ) page： 1 - 4 2020
Otological aspects of Fabry disease in patients with normal hearing
Wang, F; Yamamoto, H; Yoshida, T; Sugimoto, S; Teranishi, M; Tsuboi, K; Sone, M
NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 81 ( 3 ) page： 469 - 475 2019.8
Clinical Features of Ears With Otosclerosis and Endolymphatic Hydrops Open Access
Wang, F; Yoshida, T; Sugimoto, S; Shimono, M; Teranishi, M; Naganawa, S; Sone, M
OTOLOGY & NEUROTOLOGY Vol. 40 ( 4 ) page： 441 - 445 2019.4
Significance of internal auditory canal diverticula in ears with otosclerosis
Wang, F; Yoshida, T; Shimono, M; Sugimoto, S; Teranishi, M; Naganawa, S; Sone, M
ACTA OTO-LARYNGOLOGICA Vol. 138 ( 12 ) page： 1066 - 1069 2018.12
Significance of Endolymphatic Hydrops Herniation Into the Semicircular Canals Detected on MRI
Sugimoto, S; Yoshida, T; Teranishi, M; Kobayashi, M; Shimono, M; Naganawa, S; Sone, M
OTOLOGY & NEUROTOLOGY Vol. 39 ( 10 ) page： 1229 - 1234 2018.12
Association between Uncoupling Protein 2 Gene Ala55val Polymorphism and Sudden Sensorineural Hearing Loss. Open Access
Koide Y, Teranishi M, Sugiura S, Uchida Y, Nishio N, Kato K, Otake H, Yoshida T, Otsuka R, Ando F, Shimokata H, Hasegawa Y, Nakashima T, Sone M
The journal of international advanced otology Vol. 14 ( 2 ) page： 166 - 169 2018.8
The relationship between endolymphatic hydrops in the vestibule and low-frequency air-bone gaps. Reviewed
Sugimoto S, Yoshida T, Teranishi M, Okazaki Y, Naganawa S, Sone M
The Laryngoscope Vol. 128 ( 7 ) page： 1658 - 1662 2018.7
Imaging of the endolymphatic space in patients with Meniere's disease
Yoshida, T; Sugimoto, S; Teranishi, M; Otake, H; Yamazaki, M; Naganawa, S; Nakashima, T; Sone, M
AURIS NASUS LARYNX Vol. 45 ( 1 ) page： 33 - 38 2018.2
Significance of Endolymphatic Hydrops in Ears With Unilateral Sensorineural Hearing Loss
Okazaki, Y; Yoshida, T; Sugimoto, S; Teranishi, M; Kato, K; Naganawa, S; Sone, M
OTOLOGY & NEUROTOLOGY Vol. 38 ( 8 ) page： 1076 - 1080 2017.9
Sone, M; Yoshida, T; Sugimoto, S; Morimoto, K; Okazaki, Y; Teranishi, M; Naganawa, S; Nakashima, T
ACTA OTO-LARYNGOLOGICA Vol. 137 ( 3 ) page： 242 - 245 2017.3
Endolymphatic hydrops in patients with unilateral and bilateral Meniere's disease
Morimoto, K; Yoshida, T; Sugiura, S; Kato, M; Kato, K; Teranishi, M; Naganawa, S; Nakashima, T; Sone, M
ACTA OTO-LARYNGOLOGICA Vol. 137 ( 1 ) page： 23 - 28 2017.1
Yoshida, T; Sone, M; Kitoh, R; Nishio, S; Ogawa, K; Kanzaki, S; Hato, N; Fukuda, S; Hara, A; Ikezono, T; Ishikawa, K; Iwasaki, S; Kaga, K; Kakehata, S; Matsubara, A; Matsunaga, T; Murata, T; Naito, Y; Nakagawa, T; Nishizaki, K; Noguchi, Y; Sano, H; Sato, H; Suzuki, M; Shojaku, H; Takahashi, H; Takeda, H; Tono, T; Yamashita, H; Yamasoba, T; Usami, S
ACTA OTO-LARYNGOLOGICA Vol. 137 ( sup565 ) page： S38 - S43 2017
Accuracy of 3.0 Tesla magnetic resonance imaging in the diagnosis of intracochlear schwannoma. Reviewed
Yoshida, T. Sone, M. Naganawa, S. Nakashima, T.
Auris Nasus Larynx page： 551-4 2011.8
Intratympanic membrane congenital cholesteatoma.
Yoshida T, Sone M, Mizuno T, Nakashima T.
Int J Pediatr Otorhinolaryngol. page： 1003-5 2009.7
Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging findings and prognosis in sudden sensorineural hearing loss.
Yoshida T, Sugiura M, Naganawa S, Teranishi M, Nakata S, Nakashima T.
Laryngoscope page： 1433-7 2008.8
難聴発症および重症化に関わる遺伝的素因と後天的要因の解明研究
Grant number：24K02599 2024.4 - 2028.3
科学研究費助成事業 基盤研究(B)
和佐野 浩一郎, 清田 尚臣, 古平 毅, 内田 育恵, 吉田 忠雄
Authorship：Coinvestigator(s)
本研究では日本人において加齢性難聴の発症および重症化に関連した遺伝的素因を
明らかにするとともに、後天的要因の影響の度合いを明らかにし、難聴進行予防対策や早期
発見へ向けた施策の元となるデータを示したい。
シスプラチン同時併用放射線治療による難聴発症および重症化に関連する遺伝的素因および後天的因子をGWASによる解析により明らかにしたい。
Development of new improvement therapy for vestibular dysfunctionn
Grant number：24K02597 2024.4 - 2027.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s)
難聴者の精神的社会的影響の改善に向けたACEprogram日本語版の作成とその有用性の検討
Grant number：24K12708 2024.4 - 2027.3
科学研究費助成事業 基盤研究(C)
稲木 利英, 和佐野 浩一郎, 内田 育恵, 吉田 忠雄
Authorship：Coinvestigator(s)
オーストラリアで開発された難聴者に対するグループリハビリテーション（ACEプログラム）が鬱や不安、社会的孤立などの精神的社会的影響が有意に改善したと報告される。現在日本語翻訳されておらず、日本における有効性は検討されていない。本研究では当院補聴器外来に通院する難聴者を対象にACEプログラムを行い、その参加前後での精神的社会的影響を評価し日本における有効性を示したい。
一側性および非対称性難聴に対する雑音下語音聴取評価検査に係る至適条件の探索
Grant number：23K08943 2023.4 - 2026.3
科学研究費助成事業 基盤研究(C)
山田 悠祐, 松田 悠佑, 東野 哲也, 高橋 優宏, 岩崎 聡, 大石 直樹, 鬼頭 良輔, 中西 啓, 柿木 章伸, 藤田 岳, 石野 岳志, 吉田 忠雄, 菅原 一真, 實川 純人
Authorship：Coinvestigator(s)
一側性難聴者は、騒音下や多人数での会話において聞き取りが不自由であるにも関わらず、本邦では医療、教育、社会的支援に目が向けられてこなかった。令和2年度の日本医療研究開発機構（AMED）岩崎班の研究において、一側性難聴者の障害の現状とその対応方法に関する研究が行われた。その結果、雑音下語音検査では、検査結果に個人差が多く、医学的介入（補聴器、人工内耳等）の適応評価のための検査条件をさらに詳細に検討する必要があることがわかった。本研究の目的は、雑音下語音検査の検査条件を確立することであり、多機関共同研究とすることでより多くのデータを収集・分析し、雑音下語音検査の標準化を目指す。
Grant number：21K09605 2021.4 - 2025.3
科学研究費助成事業 基盤研究(C)
曽根 三千彦, 大神 信孝, 吉田 忠雄
Authorship：Coinvestigator(s)
メニエール病は、めまいや難聴などの症状を生じ生活の質を著しく低下させる疾患である。発作予防に対してさまざまな段階的治療法が推奨されているが、その有効性には限界がある。低侵襲で有効な治療法として、100 Hzの軽微な音刺激を連続して与えるという新たな治療法を提示し、症状や内耳機能改善効果を解析しその有効性を検証する。
めまいや聴力低下を生じるメニエール病は保存的治療で対応が可能である症例も多いが、難治性のめまいを伴う平衡障害は患者のQOLに大きな影響を及ぼし、今までそのような症例では外科的治療を含む侵襲的治療が選択されてきた。本研究では、治療抵抗性のメニエール病に対して新たに低侵襲で有効な治療法の開発を目標とし、100 Hzの軽微な音刺激が平衡感覚を改善する可能性についてメニエール病症例の低下した前庭耳石機能改善を目指した研究を開始した。
難治性めまいで来院しMRIにて内リンパ水腫が確認されたメニエール病確実例で同意の得られた症例を対象に、試作した音発生装置を用いて100Hz 75dBの刺激音を両耳に５分間与えた。刺激前後で、蝸牛機能評価として耳音響放射、平衡機能として重心動揺検査および前庭誘発筋電位検査を行った。刺激後に耳音響放射の変化はなく、蝸牛障害の副作用は生じないことを確認した。一方重心動揺検査では、刺激後に総軌跡長および外周面積のロンベルグ率が有意に低下した。また、刺激後に患側の低下した前庭誘発筋電位の振幅が有意に増大した。一方250Hz 75dBの刺激音を５分間与えたコントロール群では、ロンベルグ率の改善は認められず、かえって患側の前庭誘発筋電位の振幅は有意に減少した。
100Hz 75dBの刺激による重心動揺の改善は耳石を介した作用であり、聴覚系を介した作用と推定している。この結果を得て、音刺激時間を10分間に延長し、さらなる評価を行った。特に違和感を感じた症例はなく、遂行可能であった。
本研究でリクルートしたメニエール病患者は、保存的な治療でもコントロールが不良な不可逆期または進行期の症例であった。初診からMRI検査による内リンパ水腫確認および刺激検査まで数ヶ月を要したため、音刺激検査の際にはめまいや聴力改善のあった症例も存在したが、そのような症例も含めて100Hz 75dBの刺激音の有効性が確認されている。当初から使用している音発生装置は試作品のためサイズが大きい。今後の利便性を考慮し、ポータブルタイプの音発生装置を企業の協力を得るべく、特定臨床研究承認を得て共同研究契約もR4年度内に締結した。R5年度途中から、ヘッドホンタイプの装用機器にて音刺激研究を継続している。
ヘッドホンタイプの音刺激機器を用いてエビデンスを確立すべく、無作為抽出にて音刺激研究を継続し、症例の集積を行っていく。単施設での症例組み込みでは限界があるため、多施設共同研究の特定臨床研究へと発展させる予定である。
Auditory processing processes in bilateral cochlear implant users
Grant number：20K11183 2020.4 - 2024.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Yoshida Tadao
Authorship：Principal investigator
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
In a comparison of bilateral and unilateral implantation in sequential bilateral cochlear implant surgery cases more than 6 months after implantation, SRT was better in bilateral implantation, but the first side tended to be slightly better. However, in the interactive spatial listening test, there was no difference in the direction of the noise. However, in the interactive spatial listening test, binaural hearing aid users showed better discrimination of the minimum angle. Additive and squelch effects due to binaural use were observed, but limited effects were suggested for SRM. This is a new finding that the effect of noise on hearing is important, and that an environment in which the effect of noise on the good hearing ear is minimal is better.
Examination of deafness onset mechanism using MYH9 abnormality model mouse
Grant number：16K20240 2016.4 - 2020.3
YOSHIDA TADAO
Authorship：Principal investigator
Grant amount：\3770000 （ Direct Cost: \2900000 、 Indirect Cost：\870000 ）
The results of ABR in R702C-Atoth1 mice revealed that some mice caused hearing loss and others did not. Three out of 46 mice showed 70 dB or more in all frequency ranges. Immunostaining was performed using NMMHC-IIA (MYH9). A negative control was prepared. The expression site of the NMMHC-IIA in the inner ear was compared in three individuals in one wild-type gene expression and two expressing the deafness in the R702C-Atoth1 mice. As shown in FIGS. 2 and 3, the expression was almost the same as that of the wild type, and there was no difference between individuals. No morphological changes were observed on light microscopy and immunostaining. Since only a very small amount of the inner ear tissue sample can be obtained, the amount was insufficient to confirm that the MYH R702C gene was contained in the inner ear in a tissue-specific manner. In the future, we will focus on the morphological change of sensory hair, which is a finer structure, and study it repeatedly.
