Faculty Profiles - OKAJIMA, Tetsuya

Papers - OKAJIMA, Tetsuya

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Altered glycolipid metabolism during acute kidney injury exacerbates renal inflammation. Open Access

Osada A, Tanaka M, Sugiura Y, Yuan X, Yamashita S, Ochi K, Kohda H, Ito A, Go S, Okajima T, Kadomatsu K, Yanagita M, Furuhashi K, Maruyama S, Suganami T

Scientific reports 2025.12

Differential O- glucose elongation on a specific EGF repeat within the canonical ligand-binding domain regulates DLL1/4-NOTCH1 signaling

Tsukamoto, Y; Aoki, K; Kama, Y; Hosokawa, H; Saiki, W; Tsukamoto, N; Kato, K; Hosokawa, Y; Sato, R; Uesugi, N; Fujita, Y; Fukazawa, K; Funada, D; Suzuki, F; Kurebayashi, Y; Urata, Y; Uchiyama, S; Wang, WW; Minami, A; Takahashi, T; Tiemeyer, M; Narimatsu, Y; Okajima, T; Takeuchi, H

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA Vol. 122 ( 43 ) page： e2504827122 2025.10

Retention of DLK1 in the endoplasmic reticulum identifies roles for EGF-like-domain-specific O-glycans in the secretory pathway

Tashima, Y; Tsukamoto, Y; Tsukamoto, N; Kondo, Y; Uddin, E; Furukawa, W; Go, S; Arakawa, H; Kaji, H; Takeuchi, H; Okajima, T

FEBS JOURNAL Vol. 292 ( 20 ) page： 5355 - 5381 2025.10

<i>XXYLT1</i> inhibits NOTCH1 activation in Jurkat cells while promoting cell proliferation

Wang, WW; Saiki, W; Tsukamoto, Y; Uchiyama, S; Kondo, Y; Okajima, T; Takeuchi, H

NAGOYA JOURNAL OF MEDICAL SCIENCE Vol. 87 ( 3 ) page： 431 - 450 2025.8

O-GlcNAc glycans in the mammalian extracellular environment

Tsukamoto, Y; Okajima, T

CARBOHYDRATE RESEARCH Vol. 549 page： 109378 2025.3

The Human Glycome Atlas project for cataloging all glycan-related omics data in human Reviewed

Aoki-Kinoshita, KF; Akune-Taylor, Y; Ando, H; Angata, K; Fujita, M; Furukawa, JI; Kaji, H; Kato, K; Kitajima, K; Kizuka, Y; Matsui, Y; Nakajima, K; Nishihara, S; Okajima, T; Sakamoto, K; Sato, C; Thaysen-Andersen, M; Togayachi, A; Yagi, H; Zappa, A; Kadomatsu, K

GLYCOBIOLOGY Vol. 34 ( 11 ) 2025.1

Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance

Hashimoto, N; Ito, S; Kudo, AY; Kawasaki, N; Hashimoto, N; Ito, S; Harazono, A; Tsuchida, A; Mouri, Y; Yamamoto, A; Okajima, T; Ohmi, Y; Furukawa, K; Kudo, Y; Kawasaki, N; Furukawa, K

ISCIENCE Vol. 27 ( 11 ) page： 111139 2024.11

Revisiting of role of Eogt, atypical O-glycan synthase, based on tissue distribution

Kondo, Y; Kawai, K; Toida, N; Okajima, T

GLYCOBIOLOGY Vol. 34 ( 11 ) page： 11 - 11 2024.11

Glycoproteomics and transport assay of ER-tethered protein Delta homolog 1 highlights the role of EGF domain-specific O-glycans in the secretory pathway

Tashima, Y; Tsukamoto, Y; Tsukamoto, N; Kondo, Y; Uddin, E; Furukawa, W; Go, S; Kaji, H; Takeuchi, H; Okajima, T

GLYCOBIOLOGY Vol. 34 ( 11 ) page： 47 - 47 2024.11

The N-acetylglucosaminyltransferase Radical fringe contributes to defects in JAG1-dependent turnover and signaling of NOTCH3 CADASIL mutants Reviewed Open Access

Suzuki, S; Mashiko, T; Tsukamoto, Y; Oya, M; Kotani, Y; Okawara, S; Matsumoto, T; Mizue, Y; Takeuchi, H; Okajima, T; Itoh, M

JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 300 ( 10 ) page： 107787 2024.10

Characterization of galactosyltransferase and sialyltransferase genes mediating the elongation of the extracellular O-GlcNAc glycans Reviewed

Tsukamoto, Y; Tsukamoto, N; Saiki, W; Tashima, Y; Furukawa, JI; Kizuka, Y; Narimatsu, Y; Clausen, H; Takeuchi, H; Okajima, T

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 703 page： 149610 2024.4

Efficient Escorting Strategy for Aggregation-Prone Notch EGF Repeats with Sparcl1 Invited Reviewed

Kondo, Y; Li, YX; Okajima, T

MOLECULES Vol. 29 ( 5 ) 2024.3

Inhibitory machinery for the functional dystroglycan glycosylation Invited Reviewed Open Access

Kondo, Y; Okajima, T

JOURNAL OF BIOCHEMISTRY Vol. 173 ( 5 ) page： 333 - 335 2023.5

Evidence that only EWS among the FET proteins acquires a low partitioning property for the hyperosmotic stress response by O-GlcNAc glycosylation on its low-complexity domain Reviewed

Kakuo, M; Horii, T; Tonomura, N; Sato, R; Ogawa, M; Okajima, T; Kamemura, K

EXPERIMENTAL CELL RESEARCH Vol. 424 ( 1 ) page： 113504 2023.3

Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation Reviewed Open Access

Zhang, AL; Tsukamoto, Y; Takeuchi, H; Nishiwaki, K; Tashima, Y; Okajima, T

ANALYTICAL BIOCHEMISTRY Vol. 656 page： 114881 2022.11

Glycoproteomics of NOTCH1 EGF repeat fragments overexpressed with different glycosyltransferases in HEK293T cells reveals insights into O-GlcNAcylation of NOTCH1 Reviewed

Tsukamoto, Y; Ogawa, M; Yogi, K; Tashima, Y; Takeuchi, H; Okajima, T

GLYCOBIOLOGY Vol. 32 ( 7 ) page： 616 - 628 2022.6

Significant Roles of Notch <i>O</i>-Glycosylation in Cancer Invited Reviewed Open Access

Wang, WW; Okajima, T; Takeuchi, H

MOLECULES Vol. 27 ( 6 ) 2022.3

Ganglioside GD2 enhances malignant properties of melanoma by co-operating with integrin. Reviewed

Farhana, Y; Bhuiyan, RH; Ohmi, Y; Horiuchi, M; Okajima, T; Yamamoto, S; Furukawa, K; Furukawa, K

CANCER SCIENCE Vol. 113 page： 1104 - 1104 2022.2

Unique effects of expression of asialo-series ganglioside GD1alpha in human cancer cell lines Reviewed

Robiul, B; Yesmin, F; Kondo, Y; Ohkawa, Y; Ohmi, Y; Zhang, P; Okajima, T; Furukawa, K; Furukawa, K

CANCER SCIENCE Vol. 113 page： 379 - 379 2022.2

Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins Open Access

Yesmin, F; Bhuiyan, RH; Ohmi, Y; Yamamoto, S; Kaneko, K; Ohkawa, Y; Zhang, P; Hamamura, K; Cheung, NKV; Kotani, N; Honke, K; Okajima, T; Kambe, M; Tajima, O; Furukawa, K; Furukawa, K

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 23 ( 1 ) 2022.1

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Papers - OKAJIMA, Tetsuya