医師　豊橋市民病院

2004年6月 - 2005年3月

カリフォルニア州立大学デービス校　生化学　ポストドクトラルフェロー

2001年5月 - 2004年4月

医師　安城更正病院

1993年5月 - 1996年3月

Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity 査読有り 国際誌

Hirano, D; Hayakawa, F; Yasuda, T; Tange, N; Yamamoto, H; Kojima, Y; Morishita, T; Imoto, N; Tsuzuki, S; Mano, H; Naoe, T; Kiyoi, H

ONCOGENE   38 巻 ( 13 ) 頁： 2263 - 2274   2019年3月

EBF1-JAK2 inhibits the PAX5 function through physical interaction with PAX5 and kinase activity 査読有り 国際誌

Kojima, Y; Kawashima, F; Yasuda, T; Odaira, K; Inagaki, Y; Yamada, C; Muraki, A; Noura, M; Okamoto, S; Tamura, S; Iwamoto, E; Sanada, M; Matsumura, I; Miyazaki, Y; Kojima, T; Kiyoi, H; Tsuzuki, S; Hayakawa, F

INTERNATIONAL JOURNAL OF HEMATOLOGY   118 巻 ( 1 ) 頁： 65 - 74   2023年7月

BCL6 inhibition ameliorates resistance to ruxolitinib in <i>CRLF2</i>-rearranged acute lymphoblastic leukemia 査読有り 国際誌

Tsuzuki, S; Yasuda, T; Goto, H; Maeda, N; Akahane, K; Inukai, T; Yamamoto, H; Karnan, S; Ota, A; Hyodo, T; Konishi, H; Hosokawa, Y; Kiyoi, H; Hayakawa, F

HAEMATOLOGICA   108 巻 ( 2 ) 頁： 394 - 408   2023年2月

Oncogenic lesions and molecular subtypes in adults with B-cell acute lymphoblastic leukemia 招待有り 査読有り 国際誌

Yasuda, T; Sanada, M; Tsuzuki, S; Hayakawa, F

CANCER SCIENCE   114 巻 ( 1 ) 頁： 8 - 15   2023年1月

VWF-Gly2752Ser, a novel non-cysteine substitution variant in the CK domain, exhibits severe secretory impairment by hampering C-terminal dimer formation 査読有り 国際誌

Okamoto, S; Tamura, S; Sanda, N; Odaira, K; Hayakawa, Y; Mukaide, M; Suzuki, A; Kanematsu, T; Hayakawa, F; Katsumi, A; Kiyoi, H; Kojima, T; Matsushita, T; Suzuki, N

JOURNAL OF THROMBOSIS AND HAEMOSTASIS   20 巻 ( 8 ) 頁： 1784 - 1796   2022年8月

Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development 査読有り 国際誌

Tamura, S; Mukaide, M; Katsuragi, Y; Fujii, W; Odaira, K; Suzuki, N; Tsukiji, N; Okamoto, S; Suzuki, A; Kanematsu, T; Katsumi, A; Takagi, A; Ikeda, K; Ueyama, J; Hirayama, M; Suzuki-Inoue, K; Matsushita, T; Kojima, T; Hayakawa, F

JOURNAL OF BIOLOGICAL CHEMISTRY   298 巻 ( 5 ) 頁： 101833   2022年5月

<i>F9</i>mRNA splicing aberration due to a deep Intronic structural variation in a patient with moderate hemophilia B 査読有り 国際誌

Odaira, K; Kawashima, F; Tamura, S; Suzuki, N; Tokoro, M; Hayakawa, Y; Suzuki, A; Kanematsu, T; Okamoto, S; Takagi, A; Katsumi, A; Matsushita, T; Shima, M; Nogami, K; Kojima, T; Hayakawa, F

THROMBOSIS RESEARCH   213 巻   頁： 91 - 96   2022年5月

Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases 査読有り 国際共著 国際誌

Dai, YT; Zhang, F; Fang, H; Li, JF; Lu, G; Jiang, L; Chen, B; Mao, DD; Liu, YF; Wang, J; Peng, LJ; Feng, C; Chen, HF; Mu, JX; Zhang, QL; Wang, H; Ariffin, H; Moy, TA; Wang, JH; Lou, YJ; Chen, SN; Wang, Q; Liu, H; Shan, Z; Matsumura, I; Miyazaki, Y; Yasuda, T; Dou, LP; Yan, XJ; Yan, JS; Yeoh, AEJ; Wu, DP; Kiyoi, H; Hayakawa, F; Jin, J; Wang, SY; Sun, XJ; Mi, JQ; Chen, Z; Huang, JY; Chen, SJ

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   119 巻 ( 15 ) 頁： e2120787119   2022年4月

Decision Analysis for Unrelated Bone Marrow Transplantation or Immediate Cord Blood Transplantation for Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Remission 査読有り 国際誌

Kako, S; Hayakawa, F; Miyamura, K; Tanaka, J; Imai, K; Kanda, J; Morishima, S; Uchida, N; Doki, N; Ikegame, K; Ozawa, Y; Takada, S; Usui, N; Ohtake, S; Kiyoi, H; Matsumura, I; Miyazaki, Y; Ichinohe, T; Fukuda, T; Atsuta, Y; Kanda, Y

TRANSPLANTATION AND CELLULAR THERAPY   28 巻 ( 3 ) 頁： 161.e1 - 161.e10   2022年3月

Protein S-Leu17Pro disrupts the hydrophobicity of its signal peptide causing a proteasome-dependent degradation 査読有り 国際誌

Okada, K; Tamura, S; Suzuki, N; Odaira, K; Mukaide, M; Fujii, W; Katsuragi, Y; Suzuki, A; Kanematsu, T; Okamoto, S; Suzuki, N; Katsumi, A; Matsushita, T; Kojima, T; Hayakawa, F

THROMBOSIS RESEARCH   210 巻   頁： 26 - 32   2022年2月

Dasatinib-based 2-step induction for adults with Philadelphia chromosome-positive acute lymphoblastic leukemia 査読有り 国際誌

Sugiura, I; Doki, N; Hata, T; Cho, R; Ito, T; Suehiro, Y; Tanaka, M; Kako, S; Matsuda, M; Yokoyama, H; Ishikawa, Y; Taniguchi, Y; Hagihara, M; Ozawa, Y; Ueda, Y; Hirano, D; Sakura, T; Tsuji, M; Kamae, T; Fujita, H; Hiramoto, N; Onoda, M; Fujisawa, S; Hatta, Y; Dobashi, N; Nishiwaki, S; Atsuta, Y; Kobayashi, Y; Hayakawa, F; Ohtake, S; Naoe, T; Miyazaki, Y

BLOOD ADVANCES   6 巻 ( 2 ) 頁： 624 - 636   2022年1月

Optimal treatment for Philadelphia-negative acute lymphoblastic leukemia in first remission in the era of high-intensity chemotherapy 査読有り 国際誌

Kako, S; Hayakawa, F; Imai, K; Tanaka, J; Mizuta, S; Nishiwaki, S; Kanamori, H; Mukae, J; Ozawa, Y; Kondo, T; Fukuda, T; Ichinohe, T; Ota, S; Tanaka, Y; Murayama, T; Kurahashi, S; Sakura, T; Usui, N; Ohtake, S; Kiyoi, H; Matsumura, I; Miyazaki, Y; Atsuta, Y

INTERNATIONAL JOURNAL OF HEMATOLOGY   114 巻 ( 5 ) 頁： 608 - 619   2021年11月

Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma 査読有り 国際誌

Kunou, S; Shimada, K; Takai, M; Sakamoto, A; Aoki, T; Hikita, T; Kagaya, Y; Iwamoto, E; Sanada, M; Shimada, S; Hayakawa, F; Oneyama, C; Kiyoi, H

ONCOGENE   40 巻 ( 23 ) 頁： 3989 - 4003   2021年6月

Essential role of a carboxyl-terminal α-helix motif in the secretion of coagulation factor XI 査読有り 国際誌

Hayakawa, Y; Tamura, S; Suzuki, N; Odaira, K; Tokoro, M; Kawashima, F; Hayakawa, F; Takagi, A; Katsumi, A; Suzuki, A; Okamoto, S; Kanematsu, T; Matsushita, T; Kojima, T

JOURNAL OF THROMBOSIS AND HAEMOSTASIS   19 巻 ( 4 ) 頁： 920 - 930   2021年4月

Combination of clofarabine, etoposide, and cyclophosphamide in adult relapsed/refractory acute lymphoblastic leukemia: a phase 1/2 dose-escalation study by the Japan Adult Leukemia Study Group 査読有り 国際誌

Saito, T; Hatta, Y; Hayakawa, F; Takahashi, T; Hagihara, M; Iida, H; Minauchi, K; Yamazaki, E; Sugiura, I; Murayama, T; Sakura, T; Mori, N; Imai, K; Yahagi, Y; Atsuta, Y; Saito, AM; Hirakawa, A; Kiyoi, H; Matsumura, I; Miyazaki, Y

INTERNATIONAL JOURNAL OF HEMATOLOGY   113 巻 ( 3 ) 頁： 395 - 403   2021年3月

Exosomes derived from cancer associated fibroblasts induce a resistance to histone deacetylase inhibitors in lymphoma 査読有り 国際誌

Kagaya, Y; Shimada, K; Kunou, S; Hikita, T; Sakamoto, A; Hayakawa, F; Oneyama, C; Kiyoi, H

CANCER SCIENCE   112 巻   頁： 370 - 370   2021年2月

[B cell acute lymphoblastic leukemia therapy: an up to date overview]. 招待有り 査読有り

Hayakawa F

[Rinsho ketsueki] The Japanese journal of clinical hematology   62 巻 ( 8 ) 頁： 1094 - 1101   2021年

Functional analysis of a novel fusion protein PAX5-KIDINS220 identified in a pediatric Ph-like ALL patient 査読有り 国際誌

Kanayama, T; Imamura, T; Mayumi, A; Soma, E; Sakamoto, K; Hayakawa, F; Tanizawa, A; Kiyokawa, N; Hosoi, H

INTERNATIONAL JOURNAL OF HEMATOLOGY   112 巻 ( 5 ) 頁： 714 - 719   2020年11月

JSH practical guidelines for hematological malignancies, 2018: I. leukemia-3. acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL) 招待有り 査読有り 国際誌

Hatta, Y; Hayakawa, F; Yamazaki, E

INTERNATIONAL JOURNAL OF HEMATOLOGY   112 巻 ( 4 ) 頁： 439 - 458   2020年10月

Aberrant X chromosomal rearrangement through multi-step template switching during sister chromatid formation in a patient with severe hemophilia A 査読有り 国際誌

Tokoro, M; Tamura, S; Suzuki, N; Kakihara, M; Hattori, Y; Odaira, K; Suzuki, S; Takagi, A; Katsumi, A; Hayakawa, F; Okamoto, S; Suzuki, A; Kanematsu, T; Matsushita, T; Kojima, T

MOLECULAR GENETICS & GENOMIC MEDICINE   8 巻 ( 9 ) 頁： e1390   2020年9月

Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in <i>MEF2D</i>-fusion (+) ALL cells 査読有り 国際誌

Tange, N; Hayakawa, F; Yasuda, T; Odaira, K; Yamamoto, H; Hirano, D; Sakai, T; Terakura, S; Tsuzuki, S; Kiyoi, H

BIOMEDICINE & PHARMACOTHERAPY   128 巻   頁： 110330   2020年8月

A case of pemphigus with anti-desmoglein 3 and anti-desmocollin 2 and 3 autoantibodies, associated with follicular lymphoma and bronchiolitis obliterans 査読有り 国際誌

Yoshikawa, M; Takeichi, T; Taki, T; Hayakawa, F; Ishii, N; Hashimoto, T; Muro, Y; Akiyama, M

EUROPEAN JOURNAL OF DERMATOLOGY   30 巻 ( 4 ) 頁： 424 - 425   2020年7月

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia.

Tsuzuki S, Yasuda T, Kojima S, Kawazu M, Akahane K, Inukai T, Imaizumi M, Morishita T, Miyamura K, Ueno T, Karnan S, Ota A, Hyodo T, Konishi H, Sanada M, Nagai H, Horibe K, Tomita A, Suzuki K, Muramatsu H, Takahashi Y, Miyazaki Y, Matsumura I, Kiyoi H, Hosokawa Y, Mano H, Hayakawa F

Blood cancer discovery   1 巻 ( 1 ) 頁： 82 - 95   2020年7月

High prevalence of MEF2D fusion in human B-cell precursor acute lymphoblastic leukemia cell lines. 査読有り

Akahane K, Yasuda T, Tsuzuki S, Hayakawa F, Kiyokawa N, Somazu S, Watanabe A, Kagami K, Abe M, Harama D, Goi K, Kawazu M, Kojima S, Imamura T, Goto H, Iwamoto S, Minegishi M, Abe M, Hojo H, Inaba T, Mano H, Sugita K, Inukai T

Hematological oncology     2020年6月

Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells 査読有り 国際誌

Inoue, C; Sobue, S; Kawamoto, Y; Nishizawa, Y; Ichihara, M; Abe, A; Hayakawa, F; Suzuki, M; Nozawa, Y; Murate, T

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   525 巻 ( 4 ) 頁： 1074 - 1080   2020年5月

Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes 査読有り

Inoue Chisato, Sobue Sayaka, Mizutani Naoki, Kawamoto Yoshiyuki, Nishizawa Yuji, Ichihara Masatoshi, Takeuchi Toshiyuki, Hayakawa Fumihiko, Suzuki Motoshi, Ito Tetsuro, Nozawa Yoshinori, Murate Takashi

NAGOYA JOURNAL OF MEDICAL SCIENCE   82 巻 ( 2 ) 頁： 261-280   2020年5月

Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy 査読有り 国際誌

Ogawa, M; Suzuki, N; Takahashi, N; Tamura, S; Suzuki, A; Suzuki, S; Hattori, Y; Kakihara, M; Kanematsu, T; Kojima, T; Katsumi, A; Hayakawa, F; Kojima, T; Ishiguro, N; Kiyoi, H; Matsushita, T

THROMBOSIS RESEARCH   188 巻   頁： 103 - 105   2020年4月

Dasatinib-Based Two-Step Induction Prior to Allogeneic Hematopoietic Cell Transplantation for Newly Diagnosed Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: Results of the JALSG Ph+ALL213 Study

Sugiura Isamu, Doki Noriko, Hata Tomoko, Cho Ryuko, Ito Toshiro, Suehiro Youko, Kanamori Heiwa, Kako Shinichi, Matsuda Mitsuhiro, Yokoyama Hisayuki, Taniguchi Yasuhiro, Hagihara Maki, Ozawa Yukiyasu, Fujisawa Shin, Dobashi Nobuaki, Hatta Yoshihiro, Asada Noboru, Ohashi Kazuteru, Onishi Yasushi, Shiro Koh, Nishiwaki Satoshi, Atsuta Yoshiko, Hayakawa Fumihiko, Ohtake Shigeki, Miyazaki Yasushi

BLOOD   134 巻   2019年11月

ZNF384-fusion proteins have high affinity for the transcriptional coactivator EP300 and aberrant transcriptional activities 査読有り 国際誌

Yamamoto, H; Hayakawa, F; Yasuda, T; Odaira, K; Minamikawa, Y; Tange, N; Hirano, D; Kojima, Y; Morishita, T; Tsuzuki, S; Naoe, T; Kiyoi, H

FEBS LETTERS   593 巻 ( 16 ) 頁： 2151 - 2161   2019年8月

Apparent synonymous mutation <i>F9</i> c.87A &gt; G causes secretion failure by in-frame mutation with aberrant splicing 査読有り 国際誌

Odaira, K; Tamura, S; Suzuki, N; Kakihara, M; Hattori, Y; Tokoro, M; Suzuki, S; Takagi, A; Katsumi, A; Hayakawa, F; Okamoto, S; Suzuki, A; Kanematsu, T; Matsushita, T; Kojima, T

THROMBOSIS RESEARCH   179 巻   頁： 95 - 103   2019年7月

Molecular basis of <i>SERPINC1</i> mutations in Japanese patients with antithrombin deficiency 査読有り 国際誌

Tamura, S; Hashimoto, E; Suzuki, N; Kakihara, M; Odaira, K; Hattori, Y; Tokoro, M; Suzuki, S; Takagi, A; Katsumi, A; Hayakawa, F; Suzuki, A; Okamoto, S; Kanematsu, T; Matsushita, T; Kojima, T

THROMBOSIS RESEARCH   178 巻   頁： 159 - 170   2019年6月

[Peri-arteriolar megakaryopoietic microenvironment via reciprocal CLEC-2/PDPN axis in bone marrow]. 招待有り 査読有り

Tamura S, Suzuki-Inoue K, Ozaki Y, Hayakawa F, Kojima T

[Rinsho ketsueki] The Japanese journal of clinical hematology   60 巻 ( 7 ) 頁： 834-842   2019年

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases 査読有り 国際共著 国際誌

Li, JF; Dai, YT; Lilljebjörn, H; Shen, SH; Cui, BW; Bai, L; Liu, YF; Qian, MX; Kubota, Y; Kiyoi, H; Matsumura, I; Miyazaki, Y; Olsson, L; Tan, AM; Ariffin, H; Chen, J; Takita, J; Yasuda, T; Mano, H; Johansson, B; Yang, JJ; Yeoh, AEJ; Hayakawa, F; Chen, Z; Pui, CH; Fioretos, T; Chen, SJ; Huang, JY

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   115 巻 ( 50 ) 頁： E11711 - E11720   2018年12月

A Novel PAX5-KIDINS220 Fusion Protein Activates Multiple Signals Associated with Therapeutic Resistance 査読有り 国際誌

Kanayama, T; Imamura, T; Sakamoto, K; Hayakawa, F; Tanizawa, A; Kiyokawa, N; Hosoi, H

BLOOD   132 巻   2018年11月

Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells.

Sakamoto A, Kunou S, Shimada K, Tsunoda M, Aoki T, Iriyama C, Tomita A, Nakamura S, Hayakawa F, Kiyoi H

Cancer science     2018年11月

Biology and management of primary effusion lymphoma.

Shimada K, Hayakawa F, Kiyoi H

Blood   132 巻 ( 18 ) 頁： 1879-1888   2018年11月

Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia.

Tanaka Y, Kawazu M, Yasuda T, Tamura M, Hayakawa F, Kojima S, Ueno T, Kiyoi H, Naoe T, Mano H

Haematologica   103 巻 ( 11 ) 頁： e522-e526   2018年11月

Final analysis of the JALSG Ph+ALL202 study: tyrosine kinase inhibitor-combined chemotherapy for Ph plus ALL 査読有り 国際誌

Hatta, Y; Mizuta, S; Matsuo, K; Ohtake, S; Iwanaga, M; Sugiura, I; Doki, N; Kanamori, H; Ueda, Y; Yoshida, C; Dobashi, N; Maeda, T; Yujiri, T; Monma, F; Ito, Y; Hayakawa, F; Takeuchi, J; Kiyoi, H; Miyazaki, Y; Naoe, T

ANNALS OF HEMATOLOGY   97 巻 ( 9 ) 頁： 1535 - 1545   2018年9月

BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells. 査読有り 国際誌

Inoue C, Sobue S, Aoyama Y, Mizutani N, Kawamoto Y, Nishizawa Y, Ichihara M, Abe A, Hayakawa F, Suzuki M, Nozawa Y, Murate T

Biochemistry and biophysics reports   15 巻   頁： 69 - 75   2018年9月

Phase I study of cord blood transplantation with intrabone marrow injection of mesenchymal stem cells: A clinical study protocol 査読有り 国際誌

Goto, T; Murata, M; Terakura, S; Nishida, T; Adachi, Y; Ushijima, Y; Shimada, K; Ishikawa, Y; Hayakawa, F; Nishio, N; Nishiwaki, S; Hirakawa, A; Kato, K; Takahashi, Y; Kiyoi, H

MEDICINE   97 巻 ( 17 ) 頁： e0449   2018年4月

High Incidence of Extensive Chronic Gvhd in Patients with the <i>REG3A</i> Rs7588571 Non-GG Genotype 査読有り 国際誌

Murata, M; Koyama, D; Hanajiri, R; Okuno, S; Kamoshita, S; Julamanee, J; Takagi, E; Hirano, D; Miyao, K; Sakemura, R; Goto, T; Hayakawa, F; Seto, A; Ozawa, Y; Miyamura, K; Terakura, S; Nishida, T; Kiyoi, H

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION   24 巻 ( 3 ) 頁： S192 - S193   2018年3月

High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG 査読有り 国際誌

Sakura, T; Hayakawa, F; Sugiura, I; Murayama, T; Imai, K; Usui, N; Fujisawa, S; Yamauchi, T; Yujiri, T; Kakihana, K; Ito, Y; Kanamori, H; Ueda, Y; Miyata, Y; Kurokawa, M; Asou, N; Ohnishi, K; Ohtake, S; Kobayashi, Y; Matsuo, K; Kiyoi, H; Miyazaki, Y; Naoe, T

LEUKEMIA   32 巻 ( 3 ) 頁： 626 - 632   2018年3月

A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with <i>FLT3</i> mutations 査読有り 国際誌

Yamaura, T; Nakatani, T; Uda, K; Ogura, H; Shin, W; Kurokawa, N; Saito, K; Fujikawa, N; Date, T; Takasaki, M; Terada, D; Hirai, A; Akashi, A; Chen, F; Adachi, Y; Ishikawa, Y; Hayakawa, F; Hagiwara, S; Naoe, T; Kiyoi, H

BLOOD   131 巻 ( 4 ) 頁： 426 - 438   2018年1月

[Adult acute lymphoblastic leukemia: update on pathophysiology and management].

Hayakawa F

[Rinsho ketsueki] The Japanese journal of clinical hematology   59 巻 ( 5 ) 頁： 497 - 503   2018年

The transcriptional landscape of B-cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases 査読有り

Jian-Feng Li, Yu-Ting Dai, Henrik Lilljebjörn, Shu-Hong Shen, Bo-Wen Cui, Ling Bai, Yuan-Fang Liu, Mao-Xiang Qian, Yasuo Kubota, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki, Linda Olsson, Ah Moy Tan, Hany Ariffin, Jing Chen, Junko Takita, Takahiko Yasuda, Hiroyuki Mano, Bertil Johansson, Jun J. Yang, Allen Eng-Juh Yeoh, Fumihiko Hayakawa, Zhu Chen, Ching-Hon Pui, Thoas Fioretos, Sai-Juan Chen, Jin-Yan Huang

Proceedings of the National Academy of Sciences of the United Stats of America   in press 巻 ( in press ) 頁： in press   2018年

High incidence of extensive chronic graft-versus-host disease in patients with the <i>REG3A</i> rs7588571 non-GG genotype 査読有り 国際誌

Koyama, D; Murata, M; Hanajiri, R; Okuno, S; Kamoshita, S; Julamanee, J; Takagi, E; Hirano, D; Miyao, K; Sakemura, R; Goto, T; Hayakawa, F; Seto, A; Ozawa, Y; Miyamura, K; Terakura, S; Nishida, T; Kiyoi, H

PLOS ONE   12 巻 ( 9 ) 頁： e0185213   2017年9月

YM155 induces apoptosis through proteasome-dependent degradation of MCL-1 in primary effusion lymphoma 査読有り 国際誌

Kojima, Y; Hayakawa, F; Morishita, T; Sugimoto, K; Minamikawa, Y; Iwase, M; Yamamoto, H; Hirano, D; Imoto, N; Shimada, K; Okada, S; Kiyoi, H

PHARMACOLOGICAL RESEARCH   120 巻   頁： 242 - 251   2017年6月

Emetine elicits apoptosis of intractable B-cell lymphoma cells with <i>MYC</i> rearrangement through inhibition of glycolytic metabolism 査読有り 国際誌

Aoki, T; Shimada, K; Sakamoto, A; Sugimoto, K; Morishita, T; Kojima, Y; Shimada, S; Kato, S; Iriyama, C; Kuno, S; Harada, Y; Tomita, A; Hayakawa, F; Kiyoi, H

ONCOTARGET   8 巻 ( 8 ) 頁： 13085 - 13098   2017年2月

[Acute lymphoblastic leukemia of adolescents and young adults: from the viewpoint of physicians].

Yasuda T, Hayakawa F

[Rinsho ketsueki] The Japanese journal of clinical hematology   58 巻 ( 8 ) 頁： 1031 - 1037   2017年

[Malignant lymphoma with cardiac involvement].

Terakura S, Onji M, Iriyama C, Goto T, Ushijima Y, Shimada K, Ishikawa Y, Nishida T, Hayakawa F, Murata M, Kiyoi H

[Rinsho ketsueki] The Japanese journal of clinical hematology   58 巻 ( 3 ) 頁： 239 - 242   2017年

The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with dasatinib. 査読有り

Morishita T, Hayakawa F, Sugimoto K, Iwase M, Yamamoto H, Hirano D, Kojima Y, Imoto N, Naoe T, Kiyoi H.

Oncotarget.   7 巻   頁： 56241   2016年7月

Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions. 査読有り

Sugimoto K, Miyata Y, Nakayama T, Saito S, Suzuki R, Hayakawa F, Nishiwaki S, Mizuno H, Takeshita K, Kato H, Ueda R, Takami A, Naoe T.

Scientific Reports   6 巻   頁： 30779   2016年7月

PAX5 tyrosine phosphorylation by SYK co-operatively functions with its serine phosphorylation to cancel the PAX5-dependent repression of BLIMP1: A mechanism for antigen-triggered plasma cell differentiation. 査読有り

Inagaki Y, Hayakawa F, Hirano D, Kojima Y, Morishita T, Yasuda T, Naoe T, Kiyoi H.

Biochem Biophys Res Commun.   475 巻 ( 2 ) 頁： 176   2016年5月

SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. 査読有り

Takagi Y, Shimada K, Shimada S, Sakamoto A, Naoe T, Nakamura S, Hayakawa F, Tomita A, Kiyoi H.

Cancer Science   107 巻 ( 9 ) 頁： 1270   2016年4月

Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults. 査読有り

Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, Imoto N, Kohsaka S, Kunita A, Doi K, Sakura T, Yujiri T, Kondo E, Fujimaki K, Ueda Y, Aoyama Y, Ohtake S, Takita J, Sai E, Taniwaki M, Kurokawa M, Morishita S, Fukayama M, Kiyoi H, Miyazaki Y, Naoe T, Mano H.

Nature Genetics   48 巻 ( 5 ) 頁： 569   2016年3月

Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma. 査読有り

Shimada K, Shimada S, Sugimoto K, Nakatochi M, Suguro M, Hirakawa A, Hocking TD, Takeuchi I, Tokunaga T, Takagi Y, Sakamoto A, Aoki T, Naoe T, Nakamura S, Hayakawa F, Seto M, Tomita A, Kiyoi H.

Leukemia   30 巻 ( 7 ) 頁： 1568   2016年2月

Wnt signaling is associated with cell survival in the interaction between acute myeloid leukemia cells and stromal cells. 査読有り

Niwa Y, Minami Y, Abe A, Hayakawa F, Yamada K, Naoe T.

Leukemia & Lymphoma   57 巻 ( 9 ) 頁： 2192   2016年1月

B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia. 査読有り

Imoto N, Hayakawa F, Kurahashi S, Morishita T, Kojima Y, Yasuda T, Sugimoto K, Tsuzuki S, Naoe T, Kiyoi H.

Journal of Biological Chemistry   291 巻 ( 9 ) 頁： 4723   2016年1月

Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells. 査読有り 国際共著

Fukushima N, Minami Y, Kakiuchi S, et al.

Cancer Science   107 巻   頁： 1422   2016年

【臨床血液学-最新情報と今後の展望2016(リンパ系疾患)-】 成人急性リンパ性白血病 招待有り 査読有り

早川文彦

臨床血液   57 巻   頁： 230   2016年

Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions. 査読有り

Sugimoto K, Miyata Y, Nakayama T, et al.

Scientific reports   6 巻   頁： 30799   2016年

Discovery of a drug targeting microenvironmental support for lymphoma cells by screening using patient-derived xenograft cells 査読有り

Keiki Sugimoto, Fumihiko Hayakawa, Satoko Shimada, Takanobu Morishita, Kazuyuki Shimada, Tomoya Katakai, Akihiro Tomita, Hitoshi Kiyoi, Tomoki Naoe

Scientific reports   5 巻   頁： 13054   2015年8月

Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies. 査読有り

Ogura M, Uchida T, Terui Y, Hayakawa F, Kobayashi Y, Taniwaki M, Takamatsu Y, Naoe T, Tobinai K, Munakata W, Yamauchi T, Kageyama A, Yuasa M, Motoyama M, Tsunoda T, Hatake K.

Cancer Science   106 巻 ( 7 ) 頁： 896-901   2015年5月

Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia. 査読有り

Shinohara H, Taniguchi K, Kumazaki M, Yamada N, Ito Y, Otsuki Y, Uno B, Hayakawa F, Minami Y, Naoe T, Akao Y.

Cancer Letter   360 巻 ( 1 ) 頁： 28-38   2015年1月

Adolescent and young adult世代の急性リンパ性白血病 招待有り 査読有り

早川文彦

臨床血液   56 巻   頁： 2032   2015年

Development of acute pure red cell aplasia after deferasirox administration in two cases of myelodysplastic syndrome. 査読有り

Hayakawa F, Tomita A, Naoe T.

Rinsho Ketsueki   55 巻 ( 4 ) 頁： 445-9   2014年

Markedly improved outcomes and acceptable toxicity in adolescents and young adults with acute lymphoblastic leukemia following treatment with a pediatric protocol: a phase II study by the Japan Adult Leukemia Study Group. 査読有り

Hayakawa F, Sakura T, Yujiri T, Kondo E, Fujimaki K, Sasaki O, Miyatake J, Handa H, Ueda Y, Aoyama Y, Takada S, Tanaka Y, Usui N, Miyawaki S, Suenobu S, Horibe K, Kiyoi H, Ohnishi K, Miyazaki Y, Ohtake S, Kobayashi Y, Matsuo K, Naoe T

Blood Cancer Journal   4 巻 ( e ) 頁： 252   2014年

A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases. 査読有り

Hayakawa F, Sugimoto K, Harada Y, Hashimoto N, Ohi N, Kurahashi S, Naoe T.

Blood Cancer Journal   3 巻 ( e ) 頁： 166   2013年

GATA2 zinc finger 2 mutation found in acute myeloid leukemia impairs myeloid differentiation. 査読有り

Niimi K, Kiyoi H, Ishikawa Y, Hayakawa F, Kurahashi S, Kihara R, Tomita A, Naoe T.

Leuk Res Rep   2 巻 ( 1 ) 頁： 21-5   2013年

B cell receptor-ERK1/2 signal cancels PAX5-dependent repression of BLIMP1 through PAX5 phosphorylation: a mechanism of antigen-triggering plasma cell differentiation. 査読有り

Yasuda T,Hayakawa F,Kurahashi S, Sugimoto K, Miyami Y, Tomita A, Naoe

Journal of Immunology   188 巻 ( 12 ) 頁： 6127-34   2012年

Missense mutations in PML-RARA critical for the lack of responsiveness to arsenic trioxide treatment. 査読有り

Goto E, Tomita A, Hayakawa F, Atsumi A, Kiyoi H, Naoe T.

Blood   118 巻 ( 6 ) 頁： 1600-9   2011年

PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML. 査読有り

Kurahashi S, Hayakawa F, Miyata Y, Yasuda T, Minami Y, Tsuzuki S, Abe A, Naoe T.

Oncogene   30 巻 ( 14 ) 頁： 1822-30   2011年

The mTOR inhibitor, everolimus (RAD001), overcomes resistance to imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells. 査読有り

Kuwatsuka Y, Minami M, Minami Y, Sugimoto K, Hayakawa F, Miyata Y, Abe A, Goff DJ, Kiyoi H, Naoe T.

Blood Cancer Journal   1 巻 ( e ) 頁： 17   2011年

BCR-ABL-independent and RAS / MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4. 査読有り

Suzuki M, Abe A, Imagama S, Nomura Y, Tanizaki R, Minami Y, Hayakawa F, Ito Y, Katsumi A, Yamamoto K, Emi N, Kiyoi H, Naoe T.

Eur J Haematol.   84 巻 ( 3 ) 頁： 229-38   2010年

Retention but significant reduction of BCR-ABL transcript in hematopoietic stem cells in chronic myelogenous leukemia after imatinib therapy. 査読有り

Abe A, Minami Y, Hayakawa F, Kitamura K, Nomura Y, Murata M, Katsumi A, Kiyoi H, Jamieson CH, Wang JY, Naoe T.

Int J Hematol   88 巻 ( 5 ) 頁： 471-5   2008年

Acetylation of PML is involved in histone deacetylase Inhibitor-mediated apoptosis. 査読有り

Hayakawa F, Abe A, Kitabayashi I, Pandolfi PP, Naoe T.

J Biol Chem.   283 巻 ( 36 ) 頁： 24420-5   2008年

LRP16 is fused to RUNX1 in monocytic leukemia cell line with t(11;21)(q13;q22). 査読有り

Imagama S, Abe A, Suzuki M, Hayakawa F, Katsumi A, Emi N, Kiyoi H, Naoe T.

Eur J Haematol.   79 巻 ( 1 ) 頁： 25-31   2007年

Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing. 査読有り

Jonas BA, Varlakhanova N, Hayakawa F, Goodson M, Privalsky ML.

Mol Endocrinol   21 巻 ( 8 ) 頁： 1924-39   2007年

Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD. 査読有り

Okamoto M*, Hayakawa F*, Miyata Y, Watamoto K, Emi N, Abe A, Kiyoi H, Towatari M, Naoe T

Leukemia   21 巻 ( 3 ) 頁： 403-10   2007年

SFK-STAT pathway: an alternative and important way to malignancies. 査読有り

Hayakawa F, Naoe T

Ann N Y Acad Sci   1086 巻 ( 1 ) 頁： 213-22   2006年

Establishment of a stroma-dependent human acute myelomonocytic leukemia cell line, NAMO-2, with FLT3 tandem duplication. 査読有り

Abe A, Kiyoi H, Ninomiya M, Yamazaki T, Murase T, Ozeki K, Suzuki M, Hayakawa F, Katsumi A, Emi N, Naoe T

Int J Hematol   84 巻 ( 4 ) 頁： 328 - 336   2006年

Functional regulation of GATA-2 by acetylation. 査読有り

Hayakawa F, Towatari M, Ozawa Y, Tomita A, Privalsky ML, Saito H.

J Leukoc Biol   75 巻 ( 3 ) 頁： 529-40   2004年

Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis. 査読有り

Hayakawa F, Privalsky ML

Cancer Cell   5 巻 ( 4 ) 頁： 389-401   2004年

Life-threatening human parvovirus B19 infection transmitted by intravenous immune globulin. 査読有り

Hayakawa F, Imada K, Towatari M, Saito H.

Br J Haematol.   118 巻 ( 4 ) 頁： 1187-9   2002年

Histone deacetylase 3 associates with and represses the transcription factor GATA-2. 査読有り

Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, Tanimoto M, Saito H.

Blood   98 巻 ( 7 ) 頁： 2116-23   2001年

c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300. 査読有り

Tomita A, Towatari M, Tsuzuki S, Hayakawa F, Kosugi H, Tamai K, Miyazaki T, Kinoshita T, Saito H.

Oncogene   19 巻 ( 3 ) 頁： 444-51   2000年

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. 査読有り

Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H, Naoe T

Oncogene   19 巻 ( 5 ) 頁： 624-31   2000年

Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia. 査読有り

Hayakawa F, Towatari M, Iida H, Wakao H, Kiyoi H, Naoe T, Saito H.

Brithish Journal of Haematology   101 巻 ( 3 ) 頁： 521-8   1998年

AYA ALL に対する小児プロトコールの有効性と認容の検討：JALSG ALL202-U 研究より 招待有り

早川文彦

第56回日本小児血液・がん学会学術集会シンポジウム 

Development of growth signal inhibitors for hematopoietic malignancies 招待有り

成人B細胞性急性リンパ性白血病における融合遺伝子の情報に基づく分子生物学的な理解と新しい治療戦略の考案

研究課題番号：17cm0106525h0002  2016年4月 - 2018年3月

次世代がん医療創生研究事業 

安田　貴彦

造血器悪性腫瘍及び転移性がんで高頻度に異常を来している遺伝子を標的とした新たな治療法の開発に資する研究

研究課題番号：201313007B  2013年4月 - 2014年3月

厚生労働科学研究費補助金(厚生科研費) 

北林　一生

腫瘍抑制因子PMLのアセチル化による機能調節機構の解明とPML機能活性化による抗腫瘍療法

2006年4月 - 2007年3月

上原記念生命科学財団研究助成金 

形質細胞分化運命決定におけるMAPKシグナルの役割とその破綻によるリンパ腫発症

2013年4月 - 2015年3月

科学研究費補助金  新学術領域研究

悪性リンパ腫における微小環境依存性と治療開発に関する研究

2013年4月 - 2015年3月

科学研究費補助金  研究成果公開促進費 (研究成果公開発表)

直江 知樹

PML の SUMO E3リガーゼ同定によるPML NB形成機構解明　

2008年4月 - 2011年3月

科学研究費補助金  基盤研究(C)

白血病関連遺伝子産物PMLのアセチル化の意義

2006年4月 - 2008年3月

科学研究費補助金  若手研究(B)

血液検査学実習Ａ

2020

臨床医学Ⅱ

2020

検査技術科学特論Ｉ（形態系）

2020

血液検査学ＩＩ

2020

血液検査学Ｉ

2020

臨床病理学演習

2020