Organization
Graduate School of Medicine Program in Integrated Medicine Microbiology and Immunology Lecturer
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Lecturer
ITO, Sachiko
Degree 1
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博士（医学） （ 2005.5 名古屋大学 ）
Research Interests 2
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腫瘍免疫
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免疫学
Research Areas 1
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Life Science / Immunology / Immunology
Professional Memberships 2
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日本免疫学会
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日本癌学会
Papers 53
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Autologous peripheral blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia is safe but poses challenges for long-term maintenance of molecular remission: Results of the Auto-Ph17 study Reviewed
Nishiwaki S, Sugiura I, Sato T, Kobayashi M, Osaki M, Sawa M, Adachi Y, Okabe M, Saito S, Morishita T, Kohno A, Nishiyama T, Iida H, Kurahashi S, Kuwatsuka Y, Sugiyama D, Ito S, Nishikawa H, Kiyoi H.
eJHaem Vol. 4 ( 2 ) page： 358 - 369 2023
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CD4+ T cells are essential for the development of destructive thyroiditis induced by anti-PD-1 antibody in thyroglobulin-immunized mice. Reviewed
Yasuda Y, Iwama S, Sugiyama D, Okuji T, Kobayashi T, Ito M, Okada N, Enomoto A, Ito S, Yan Y, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Takagi H, Hagiwara D, Goto M, Suga H, Banno R, Takahashi M, Nishikawa H, Arima H.
Sci Transl Med. Vol. 13 ( 593 ) page： eabb7495. 2021.5
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Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors. Reviewed
Kobayashi T, Iwama S, Sugiyama D, Yasuda Y, Okuji T, Ito M, Ito S, Sugiyama M, Onoue T, Takagi H, Hagiwara D, Ito Y, Suga H, Banno R, Nishikawa H, Arima H.
J Immunother Cancer. Vol. 9 ( 5 ) page： e002493 2021.5
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Newly emerged immunogenic neoantigens in established tumors enable hosts to regain immunosurveillance in a T cell-dependent manner Reviewed
Muramatsu T, Noguchi T, Sugiyama D, Kanada Y, Fujimaki K, Ito S, Gotoh M, Nishikawa H.
Int Immunol. Vol. 33 ( 1 ) page： 39 - 48 2021.1
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Selective inhibition of low-affinity memory CD8+ T cells by corticosteroids. Reviewed
Tokunaga A, Sugiyama D, Maeda Y, Warner AB, Panageas KS, Ito S, Togashi Y, Sakai C, Wolchok JD, Nishikawa H
J Exp Med. 2019.9
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GADD34 suppresses lipopolysaccharide-induced sepsis and tissue injury through the regulation of macrophage activation Reviewed
Ito S, Tanaka Y, Oshino R, Okado S, Hori M, Isobe KI.
Cell Death Dis. Vol. 7 2016.6
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Vancomycin-sensitive bacteria trigger development of colitis-associated colon cancer by attracting neutrophils. Reviewed
Tanaka Y, Ito S, Isobe K.
Sci Rep. Vol. 6 2016
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GADD34 Promotes Tumor Growth by Inducing Myeloid-derived Suppressor Cells. Reviewed
Liu L, Ito S, Nishio N, Sun Y, Tanaka Y, Isobe K.
Anticancer Res. Vol. 36 ( 9 ) page： 4623 - 4628 2016
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Transfusion of CD206+ M2 Macrophages Ameliorates Antibody-Mediated Glomerulonephritis in Mice. Reviewed
Du Q, Tsuboi N, Shi Y, Ito S, Sugiyama Y, Furuhashi K, Endo N, Kim H, Katsuno T, Akiyama S, Matsuo S, Isobe KI, Maruyama S.
Am J Pathol. Vol. 186 ( 12 ) page： 3176-3188 2016
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Thymic Epithelial Cells Induced from Pluripotent Stem Cells by a Three-Dimensional Spheroid Culture System Regenerates Functional T Cells in Nude Mice. Reviewed
Okabe M, Ito S, Nishio N, Tanaka Y, Isobe K.
Cell Reprogram. Vol. 17 ( 5 ) page： 368-75 2015.9
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Effects of growth arrest and DNA damage-inducible protein 34 (GADD34) on inflammation-induced colon cancer in mice. Reviewed
Tanaka Y, Ito S, Oshino R, Chen N, Nishio N, Isobe K.
Br J Cancer. Vol. 113 ( 4 ) page： 669-679 2015
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Angioblast Derived from ES Cells Construct Blood Vessels and Ameliorate Diabetic Polyneuropathy in Mice. Reviewed
Himeno T, Kamiya H, Naruse K, Cheng Z, Ito S, Shibata T, Kondo M, Kato J, Okawa T, Fujiya A, Suzuki H, Kito T, Hamada Y, Oiso Y, Isobe K, Nakamura J.
J Diabetes Res 2015
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Growth arrest and DNA damage-inducible protein (GADD34) enhanced liver inflammation and tumorigenesis in a diethylnitrosamine (DEN)-treated murine model. Reviewed
Chen N, Nishio N, Ito S, Tanaka Y, Sun Y, Isobe K.
Cancer Immunol Immunother. Vol. 64 ( 6 ) page： 777-789 2015
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Enhancement of the acrolein-induced production of reactive oxygen species and lung injury by GADD34. Reviewed
Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Liu L, Isobe K.
Oxid Med Cell Longev 2015
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GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy. Reviewed
Ito S, Tanaka Y, Oshino R, Aiba K, Thanasegaran S, Nishio N, Isobe K.
Sci Rep. 2015
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GADD34 Facilitates Cell Death Resulting from Proteasome Inhibition. Reviewed
Liu L, Ito S, Nishio N, Sun Y, Chen N, Tanaka Y, Isobe K
Anticancer Res. Vol. 35 ( 10 ) page： 5317-24 2015
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Loss of GADD34 induces early age-dependent deviation to the myeloid lineage. Reviewed
Nishio N, Ito S, Isobe K.
Immunol Cell Biol. 2014.2
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Acrolein induced both pulmonary inflammation and the death of lung epithelial cells. Reviewed
Sun Y, Ito S, Nishio N, Tanaka Y, Chen N, Isobe K.
Toxicol Lett. Vol. 229 ( 2 ) page： 384-92 2014.2
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Recruitment of Gr1+CD11b +F4/80 + Population in the Bone Marrow and Spleen by Irradiation-Induced Pulmonary Damage. Reviewed
Thanasegaran S, Ito S, Nishio N, Uddin MN, Sun Y, Isobe KI.
Inflammation 2014
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Negative regulation of GADD34 on myofibroblasts during cutaneous wound healing. Reviewed
Liu L, Nishio N, Ito S, Tanaka Y, Isobe K.
Biomed Res Int. 2014
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Establishment of Self-Renewable GM-CSF-Dependent Immature Macrophages In Vitro from Murine Bone Marrow Reviewed
Ito S, Tanaka Y, Nishio N, Thanasegaran S, Isobe K.
PLoS One 2013.10
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Overexpression of L1CAM is Associated with Tumor Progression and Prognosis via ERK Signaling in Gastric Cancer Reviewed
Ito T, Yamada S, Tanaka C, Ito S, Murai T, Kobayashi D, Fujii T, Nakayama G, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Kodera Y.
Annals of Surgical Oncology 2013.9
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No immunogenicity of IPS cells in syngeneic host studied by in vivo injection and 3D scaffold experiments. Reviewed
Thanasegaran S, Cheng Z, Ito S, Nishio N, Isobe K.
Biomed Res Int. 2013.4
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iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis. Reviewed
Kito T, Shibata R, Ishii M, Suzuki H, Himeno T, Kataoka Y, Yamamura Y, Yamamoto T, Nishio N, Ito S, Numaguchi Y, Tanigawa T, Yamashita JK, Ouchi N, Honda H, Isobe K, Murohara T.
Sci Rep. 2013
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Characteristics of cardiac aging in C57BL/6 mice Reviewed
Zhao Cheng, Sachiko Ito, Naomi Nishio, Suganya Thanasegaran, He Fang, Ken-ichi Isobe
Experimental Gerontology Vol. 48 page： 341–348 2013
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Transplantation of neural crest-like cells derived from induced pluripotent stem cells improves diabetic polyneuropathy in mice. Reviewed
Okawa T, Kamiya H, Himeno T, Kato J, Seino Y, Fujiya A, Kondo M, Tsunekawa S, Naruse K, Hamada Y, Ozaki N, Cheng Z, Kito T, Suzuki H, Ito S, Oiso Y, Nakamura J, Isobe K.
Cell Transplant Vol. 22 ( 10 ) page： 1763-1783 2013
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Mesenchymal stem cell-like cells derived from mouse induced pluripotent stem cells ameliorate diabetic polyneuropathy in mice. Reviewed
Himeno T, Kamiya H, Naruse K, Cheng Z, Ito S, Kondo M, Okawa T, Fujiya A, Kato J, Suzuki H, Kito T, Hamada Y, Oiso Y, Isobe K, Nakamura J.
Biomed Res Int. 2013
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Autophagic activity in thymus and liver during aging. Reviewed
Uddin MN, Nishio N, Ito S, Suzuki H, Isobe K.
Age Vol. 34 ( 1 ) page： 75-85 2012.2
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Analysis of beta-Amyloid Peptide -Binding Proteins in Microglial Cells Reviewed
Sachiko Ito, Naomi Nishio, Ken-chi Isobe
The Open Geriatric Medicine Journal Vol. 5 page： 1-6 2012
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Transplantation of Neural Crest Like Cells Derived from induced Pluripotent Stem Cells Improves Diabetic Polyneuropathy in Mice. Reviewed
Okawa T, Kamiya H, Himeno T, Kato J, Seino Y, Fujiya A, Kondo M, Tsunekawa S, Naruse K, Hamada Y, Ozaki N, Cheng Z, Kito T, Suzuki H, Ito S, Oiso Y, Nakamura J, Isobe KI.
Cell Transplantation 2012
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Aging in the mouse and perspectives of rejuvenation through induced pluripotent stem cells (iPSCs).
Isobe K, Cheng Z, Ito S, Nishio N.
Results Probl Cell Differ Vol. 55 page： 413-427 2012
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Comparative angiogenic activities of induced pluripotent stem cells derived from young and old mice. Reviewed
Suzuki H, Shibata R, Kito T, Yamamoto T, Ishii M, Nishio N, Ito S, Isobe K, Murohara T.
PLoS One Vol. 7 ( 6 ) 2012
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Dextran sulphate sodium increases splenic Gr1(+)CD11b(+) cells which accelerate recovery from colitis following intravenous transplantation. Reviewed
Zhang R, Ito S, Nishio N, Cheng Z, Suzuki H, Isobe KI.
Clin Exp Immunol. Vol. 164 ( 3 ) page： 417-427 2011
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Gadd34 induces autophagy through the suppression of the mTOR pathway during starvation. Reviewed
Uddin MN, Ito S, Nishio N, Suganya T, Isobe K.
Biochem Biophys Res Commun. Vol. 407 ( 4 ) page： 692-698 2011
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Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells Reviewed
Zhao Cheng, Sachiko Ito, Naomi Nishio et al.
Journal of Molecular Cell Biology Vol. 3 ( 2 ) page： 91-98 2011
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GADD34 suppresses wound healing by upregulating expression of myosin IIA. Reviewed
Tanaka C, Ito S, Nishio N, Kodera Y, Sakurai H, Suzuki H, Nakao A, Isobe K.
Transgenic Res. Vol. 19 ( 4 ) page： 637-645 2010.9
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Toxic effects of d-galactose on thymus and spleen that resemble aging. Reviewed
Uddin MN, Nishio N, Ito S, Suzuki H, Isobe KI.
J Immunotoxicol page： 1-9 2010.1
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Antibodies to wounded tissue enhance cutaneous wound healingImmunology. Reviewed
Nishio N, Ito S, Suzuki H, Isobe K.
Immunology Vol. 128 ( 3 ) page： 369-380 2009.11
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Injection of bleomycin in newborn induces autoimmune salivalitis that is transferred by CD4T cells Reviewed
Ishikawa H, Ito S, Nishio N, Yuzawa Y, Matsuo S, Isobe K.
Immunol Cell Biol. Vol. 87 page： 351-358 2009
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*Inhibition of reactive oxygen species down-regulates protein synthesis in RAW 264.7 Reviewed
Kimura K, Ito S, Nagino M, Isobe K
Biochem Biophys Res Commun Vol. 372 page： 272-275 2008
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Thymic involution correlates with severe ulcerative colitis induced by oral administration of dextran sulphate sodium in C57BL/6 mice but not in BALB/c mice. Reviewed
Sasaki S, Ishida Y, Nishio N, Ito S, Isobe K.
Inflammation Vol. 579 page： 319-328 2008
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*Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-beta stimulation via the PI3K/Akt pathway. Reviewed
Ito S, Kimura K, Haneda M, Ishida Y, Sawada M, Isobe K.
Experimental Gerontology Vol. 42 page： 532-537 2007
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Age-dependent changes in dopaminergic projections from the substantia nigra pars compacta to the neostriatum Reviewed
Ishida Y, Okawa Y, Ito S, Shirokawa T, Isobe K.
Neuroscience Letters Vol. 418 page： 257-261 2007
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*Amyloid-beta peptides induce several chemokine mRNA expressions in the primary microglia and Ra2 cell line via the PI3K/Akt and/or ERK pathway Reviewed
Ito S, Sawada M, Haneda M, Ishida Y, Isobe K.
Neurosceience Research Vol. 56 page： 294-299 2006
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Cellular and systemic defense system against age-promoting stimuli
Isobe K, Ito S, Haneda M, Ishida Y
Nagoya Journal of Medical Science Vol. 68 page： 9-18 2006
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Analysis of growth hormone receptor polymorphism in Japanese semisuper centenarians
Du Y, Hirose N, Ping J, Ishida Y, Kojima T, Arai Y, Inagaki H, GondoY, Sakaki Y, Haneda M, Ito S, Isobe K.
Geriatrics and Gerontology International Vol. 6 page： 82-86 2006
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*Amyloid-beta peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells Reviewed
Ito S, Sawada M, Haneda M, Fujii S, Oh-Hashi K, Kiuchi K, Takahashi M, Isobe K.
FEBS Letters Vol. 579 page： 1995-2000 2005
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Effects of hyperbaric oxygen on GDNF expression and apoptosis in spinal cord injury. Reviewed
Yu Y, Matsuyama Y, Yanase M, Ito S, Adachi K, Satake K, Ishiguro N, Kiuchi K.
Neuroreport Vol. 15 page： 2369-2373 2004
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The 5'-untranslated region of the mouse glial cell line-derived neurotrophic factor gene regulates expression at both the transcriptional and translational levels. Reviewed
Tanaka M, Ito S, Kiuchi K.
Brain Res Mol Brain Res. Vol. 91 ( 1-2 ) page： 81 - 95 2001.6
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Promoter analysis and characteristics of the 5'-untranslated region of the mouse glial cell line-derived neurotrophic factor gene. Reviewed
Tanaka M, Ito S, Matsushita N, Mori N, Kiuchi K.
Brain Res Mol Brain Res. Vol. 85 ( 1-2 ) page： 91 - 102 2000.12
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Novel alternative promoters of mouse glial cell line-derived neurotrophic factor gene. Reviewed
Tanaka M, Ito S, Kiuchi K.
Biochim Biophys Acta. Vol. 1494 ( 1-2 ) page： 63 - 74 2000.11
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Cloning, expression profile, and genomic organization of the mouse STAP/A170 gene. Reviewed
Okazaki M, Ito S, Kawakita K, Takeshita S, Kawai S, Makishima F, Oda H, Kakinuma A.
Genomics. Vol. 60 ( 1 ) page： 87 - 95 1999.8
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Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR alpha. Reviewed
Nomoto S, Ito S, Yang LX, Kiuchi K.
Biochem Biophys Res Commun. Vol. 244 ( 3 ) page： 849 - 853 1998.3
Books 2
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がん免疫の基礎
伊藤 佐知子 西川 博嘉（ Role： Joint author）
日本医師会雑誌 2019.2
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Surgical Trauma & Immunological Responses
（ Role： Sole author）
2011.6
Presentations 1
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がんと免疫〜がん免疫療法の進展〜
伊藤佐知子
日本医師会生涯教育講座 2019.9.7 名古屋内科医会
Research Project for Joint Research, Competitive Funding, etc. 3
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免疫チェックポイント阻害によるT細胞活性化と耐性機構のモデル動物による解析
2019.4 - 2022.3
国立研究開発法人国立がん研究センター がん研究開発費
Grant type：Competitive
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先端的がん免疫モニタリング法開発体制に関する研究
2016.4 - 2019.3
国立研究開発法人国立がん研究センター がん研究開発費
Grant type：Competitive
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T細胞応答の多様性回復による がん免疫併用療法の開発
2016 - 2017
日本医療研究 開発機構研究費 (革新的がん医療実用化研究事業)
Grant type：Competitive
KAKENHI (Grants-in-Aid for Scientific Research) 5
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がん免疫療法の治療抵抗性に関わる遺伝子変異による抗腫瘍免疫応答減弱機構の解明
2022.4 - 2025.3
科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator
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自然免疫応答および炎症関連性癌発症におけるGADD34の機能解析
2015.4 - 2018.3
科学研究費補助金 基盤研究(C)
伊藤佐知子
Authorship：Principal investigator
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細胞増殖・移動と栄養制御ストレスに対する細胞防御におけるＧＡＤＤ３４の機能解析
2012.4 - 2015.3
科学研究費補助金 基盤研究(C)
伊藤佐知子
Authorship：Principal investigator
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老化と栄養制御、創傷治癒におけるＧＡＤＤ３４の遺伝子欠損マウスを用いた機能解析
2010.4 - 2012.3
科学研究費補助金 若手研究(B)
伊藤 佐知子
Authorship：Principal investigator
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ＳＳＴ―ＲＥＸによるミクログリア由来Ａβ結合蛋白質の発現クローニングと機能解析
2007 - 2009
科学研究費補助金 若手研究(B)
伊藤 佐知子
Authorship：Principal investigator
Teaching Experience (On-campus) 19
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免疫と生体防御
2023
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基礎医科学実習 ベーシックトレーニング
2023
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基礎医科学実習 ベーシックトレーニング
2022
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免疫と生体防御
2022
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免疫と生体防御
2021
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基盤医科学実習（スーパーベーシックトレーニング）
2021
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免疫と生体防御
2020
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基盤医科学実習（スーパーベーシックトレーニング）
2020
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免疫と生体防御
2019
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基盤医科学実習（スーパーベーシックトレーニング）
2019
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免疫と生体防御
2018
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免疫と生体防御
2017
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免疫と生体防御
2016
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免疫と生体防御 実習
2015
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免疫と生体防御 実習
2014
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免疫と生体防御 実習
2013
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免疫と生体防御 実習
2012
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免疫と生体防御 実習
2011
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免疫と生体防御 実習
2010