Updated on 2024/03/19
Doctor of Medicine
maintenance of immune homeostasis
CD8+
regulatory T cells
Others / Others / Immunology
Study on T cells regulating Immune Response
Studies on the development, function, and role of CD8+ regulatory T cells
Study of identifying factors that support the survival of resting T cells
Study on Mice Lacking β chain of the Interleukin-2 Receptor
The role of Fas/FasL in total body
Associate Professor, Nagoya University Graduate School of Medicine
2007.4
Country：Japan
名古屋大学大学院医学系研究科 助教授
2000.1
Country：Japan
名古屋大学医学部 講師
1996.3 - 1999.12
Country：Japan
Nagasaki University Graduate School, Division of Medicine oncology
- 1990
Country： Japan
Nagoya University Faculty of Medicine Medicine
- 1984
Country： Japan
日本免疫学会
Japanese Society for Cell Death Research
2009.4
日本癌学会
日本分子生物学会
Gastroenterology Review Vol. 18 ( 1 ) page： 76 - 84 2023
CD8+CD122+CD49dlow regulatory T cells maintain T cell homeostasis by killing activated T cells via Fas/FasL pathway-mediated cytotoxicity. Reviewed
Akane K, Kojima S, Mak TW, Shiku H, Suzuki H
Proceedings of the National Academy of Science, the United States of America Vol. 113 ( 9 ) page： 2460-2465 2016.3
TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cells. Reviewed
Takada K, Van Laethem F, Xing Y, Akane K, Suzuki H, Murata S, Tanaka K, Jameson SC, Singer A, Takahama Y.
Nature Immunology Vol. 16 ( 10 ) page： 1069-1076 2015
Acceleration of ileal pacemaker activity in mice lacking interleukin 10. Reviewed
Shozib HB, Suzuki H, Iino S, Nakayama S.
Inflamm Bowel Dis. Vol. 19 ( 8 ) page： 1577-1585 2013.7
CD8+CD122+ regulatory T cells contain clonally expanded cells with identical CDR3 sequences of the T cell receptor β chain. Reviewed
Okuno Y, Murakoshi A, Negita M, Akane K, Kojima S, Suzuki H.
Immunology Vol. 139 ( 3 ) page： 309-317 2013.7
Autophagic activity in thymus and liver during aging. Reviewed
Uddin MN, Nishio N, Ito S, Suzuki H, Isobe KI.
Age (Dordr) Vol. 34 ( 1 ) page： 75-85 2012.2
Dextran sulphate sodium increases splenic Gr1+CD11b+ cells which accelerate recovery from colitis following intravenous transplantation. Reviewed
Zhang R, Ito S, Nishio N, Cheng Z, Suzuki H, Isobe KI.
Clin Exp Immunol, Vol. 164 ( 3 ) page： 417-427 2011.6
Cladribine enhances apoptotic cell death in lung carcinoma cells over-expressing DNase γ. Reviewed
Hayakawa A, Suzuki H, Kamei Y, Tanuma S, Magae J
Biol Pharm Bull. Vol. 34 page： 1001-1004 2011
Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells. Reviewed
Cheng Z, Ito S, Nishio N, Xiao H, Zhang R, Suzuki H, Okawa Y, Murohara T, Isobe K
J Mol Cell Biol Vol. 3 page： 91-98 2011
Up-regulation of Gr1+CD11b+ population in spleen of dextrransulfate sodium administered mice works to repair colitis. Reviewed
Zhang R, Ito S, Nishio N, Cheng Z, Suzuki H, Isobe K
Inflamm Allergy Drug Targets Vol. 10 page： 39-46 2011
Differentiation of induced pluripotent stem cells to thymic epithelial cells by phenotype. Reviewed
Inami Y, Yoshikai T, Ito S, Nishio N, Suzuki H, Sakurai H, Isobe K-I
Immunol Cell Biol Vol. 89 page： 314-321 2011
CD8+CD122+ Regulatory T Cells and CD4+ Treg Cooperatively Prevent and Cure CD4+ cell-induced Colitis Reviewed
Agustina Tri Endharti, Yusuke Okuno, Zhe Shi, Nobuaki Misawa, Shinya Toyokuni, Masafumi Ito, Ken-ichi Isobe, and Haruhiko Suzuki
The Journal of Immunology Vol. 186 page： 41-52 2011
GADD34 suppresses wound healing by upregulating expression of myosin IIA. Reviewed
Tanaka C, Ito S, Nishio N, Kodera Y, Sakurai H, Suzuki H, Nakao A, Isobe K
Transgenic Res Vol. 19 page： 637-645 2010
Toxic effects of d-galactose on thymus and spleen that resemble aging. Reviewed
Uddin MN, Nishio N, Ito S, Suzuki H, Isobe K
J Immunotoxicol Vol. 7 page： 165-173 2010
Intra-bone marrow bone marrow transplantation rejuvenates the B cell lineage in aged mice. Reviewed
Hida D, Ishiguro N, Haneda M, Ishida Y, Suzuki H, Isobe K
Immunol Cell Biol Vol. 88 page： 87-94 2010
Antibodies to wounded tissue enhances cutaneous wound healing. Reviewed
Nishio N, Ito S, Suzuki H, Isobe K
Immunology Vol. 128 page： 369-380 2009
アレルギー性脳炎を抑制するCD8+CD122+レギュラトリーT細胞 Invited
鈴木治彦
臨床免疫・アレルギー科 Vol. 51 page： 25-32 2009
*Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg. Reviewed
Shi Z, Okuno Y, Rifa'i M, Endharti AT, Akane K, Isobe KI, Suzuki H
Eur. J. Immunol. Vol. 39 page： 2106-2119 2009
*Essential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis. Reviewed
Lee YH, Ishida Y, Rifa'i M, Shi Z, Isobe K, Suzuki H
J. Immunol. Vol. 180 page： 825-832 2008
Are CD8+CD122+ cells regulatory T cells or memory T cells? Reviewed
Suzuki H, Shi Z, Okuno Y, Isobe K.
Hum. Immunol. Vol. 69 page： 751-754 2008
CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-αβTCR interaction and become IL-10-producing active regulatory cells Reviewed
Rifa'i M, Shi Z, Zhang SY, Lee YH, Shiku H, Isobe K, Suzuki H
Int. Immunol. Vol. 20 page： 937-947 2008
Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells. Reviewed
Shi Z, Rifa'i M, Lee YH, Shiku H, Isobe K, Suzuki H
Immunology Vol. 124 page： 121-128 2008
CD8+CD122+制御性T細胞による免疫制御 Invited
鈴木治彦
医学のあゆみ Vol. 220 page： 525-526 2007
CD8+制御性T細胞とその免疫制御における研究の動向 Invited
鈴木治彦
実験医学 Vol. 25 page： 2850-2855 2007
CD8+の制御性T細胞 Invited
鈴木治彦
炎症と免疫 Vol. 15 page： 23-28 2007
A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities. Reviewed
Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H, Isobe K, Nakashima I.
FEBS Lett. Vol. 580 page： 839-843 2006
CD8+CD122+制御性T細胞 Invited
鈴木治彦
実験医学増刊号 Vol. 24 page： 122-129 2006
CD8+CD122+レギュラトリーT細胞 Invited
鈴木治彦
臨床免疫・アレルギー科 Vol. 46 page： 533-540 2006
CD8陽性CD122陽性制御性T細胞 Invited
鈴木治彦
感染・炎症・免疫 Vol. 36 page： 84-86 2006
Galectin-1 supports survival of naïve T cells without promoting cell proliferation. Reviewed
Endharti AT., Zhou YW., Nakashima I., and Suzuki H.
Eur. J. Immunol. Vol. 35 page： 86-97 2005
CD8+CD122+制御性T細胞のT細胞抑制機構とその役割 Invited
鈴木治彦
Molecular Medicine免疫2006 page： 170-177 2005
CD8+CD122+制御性T細胞の免疫ホメオスタシス維持における役割 Invited
鈴木治彦
Annual Review免疫2006 page： 174-181 2005
*CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-g production and proliferation of CD8+ T cells. Reviewed
Endharti AT., Rifai M., Shi Z., Fukuoka Y., Nakahara Y., Kawamoto Y., Takeda K., Isobe K-I., and Suzuki H.
J. Immunol. Vol. 175 page： 7093-7097 2005
Redox control of catalytic activities of membrane-associated protein tyrosine kinases. Reviewed
Nakashima I., Takeda K., Kawamoto Y., Okuno Y., Kato M., and Suzuki H.
Arch. Biochem. Biophys. Vol. 434 page： 3-10 2005
c-Kit targeting immunotherapy for hereditary melanoma in a mouse model. Reviewed
Kato M., Takeda K., Kawamoto Y., Tsuzuki T., Hossain K., Tamakoshi A., Kunisada T., Kambayashi Y., Ogino K., Suzuki H., Takahashi M., and Nakashima I.
Cancer Res. Vol. 64 page： 801-806 2004
CD8+CD122+ regulatory T cells Invited
Haruhiko Suzuki
Vol. 42 page： 515-522 2004
Evidence of a novel IL-2/15Rb-targeted cytokine involved in homeostatic proliferation of memory CD8+ T cells. Reviewed
Kamimura D., Ueda N., Sawa Y., Hachida S., Atsumi T., Nakagawa T., Sawa S-I., Jin G-H., Suzuki H., Ishihara K., Murakami M., and Hirano T.
J. Immunol. Vol. 173 page： 6041-6049 2004
*Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis. Reviewed
Rifa'i M., Kawamoto Y., Nakashima I., and Suzuki H.
J. Exp. Med. Vol. 200 page： 1123-1134 2004
Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism. Reviewed
Tsuboi H, Hossain K, Akhand AA, Takeda K, Du J, Rifa'i M, Dai Y, Hayakawa A, Suzuki H, Nakashima I.
J. Cell. Biochem. Vol. 93 page： 162-172 2004
Inhibition of Fas-mediated apoptotic cell death of murine T lymphocytes in a mouse model of immunosenescence in linkage to deterioration in cell membrane raft function. Reviewed
Yokoyama T, Du J, Kawamoto Y, Suzuki H, Nakashima I.
Immunology Vol. 112 page： 64-71 2004
Identification of RET autophosphorylation sites by mass spectrometry. Invited Reviewed
59. Kawamoto Y., Takeda K., Okuno Y., Yamakawa Y., Ito Y., Taguchi R., Kato M., Suzuki H., Takahashi M., and Nakashima I.
J. Biol. Chem. Vol. 279 page： 14213-14224 2004
Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation. Reviewed
Hossain K., Akhand AA., Kawamoto Y., Du J., Takeda K., Wu J., Yoshihara M., Tsuboi H., Kato M., Suzuki H., and Nakashima I.
Free Radic Biol Med. Vol. 34 page： 598-606 2003
4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions. Reviewed
Nakashima I., Liu W., Akhand AA., Takeda K., Kawamoto Y., Kato M., and Suzuki H.
Mol. Aspects Med. Vol. 24 page： 231-238 2003
Murine lymph node-derived stromal cells effectively support survival but induce no activation/proliferation of peripheral resting T cells in vitro. Reviewed
Zhou YW., Aritake S., Endharti AT., Wu J., Hayakawa A., Nakashima I., and Suzuki H.
Immunology Vol. 109 page： 496-503 2003
Involvement of MKK6 in TCRalpha-betaintCD69lo: a target population for apoptotic cell death in thymocytes. Reviewed
Suzuki H., Wu J., Hossain K., Ohhata T., Du J., Akhand AA., Hayakawa A., Kimura H., Hagiwara M., and Nakashima I.
FASEB J. Vol. 17 page： 1538-1540 2003
Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal. Reviewed
Liu W., Akhand AA., Takeda K., Kawamoto Y., Itoigawa M., Kato M., Suzuki H., Ishikawa N., and Nakashima I.
Cell Death Differ. Vol. 10 page： 772-781 2003
Involvement of MEKK1/ERK/P21Waf1/Cip1 signal transduction pathway in inhibition of IGF-I-mediated cell growth response by methylglyoxal. Reviewed
Du J., Cai S., Suzuki H., Akhand AA., Ma X., Takagi Y., Miyata T., Nakashima I., and Nagase F.
J Cell Biochem. Vol. 88 page： 1235-1246 2003
Redox-linked signal transduction pathways for protein tyrosine kinase activation.
Antioxid Redox Signal. Vol. 4 page： 517-531 2002
Modes of activation of mitogen-activated protein kinases and their roles in cepharantine-induced apoptosis in human leukemia cells.
Cell. Signal. Vol. 14 page： 509-515 2002
Activation of caspase-8 is critical for sensitivity to cytotoxic anti-Fas antibody-induced apoptosis in human ovarian cancer cells.
Apoptosis Vol. 7 page： 107-113 2002
Evidence of both extra- and intracellular cysteine targets of protein modification for activation of RET kinase.
Biochem Biophys Res Commun. Vol. 292 page： 826-831 2002
Redox control of T-cell death.
Antioxid Redox Signal. Vol. 4 page： 353-356 2002
Redox-linked cell surface-oriented signaling for T-cell death.
Antioxid Redox Signal. Vol. 4 page： 445-454 2002
Glyoxal and methylglyoxal induce lyoxal and methyglyoxal induce aggergation and inactivation of ERK in human endothelial cells.
Free Radic. Biol. Med. Vol. 31 page： 1228-1235 2001
Mice lacking interleukin-2 (IL-2)/IL-15 receptor b chain are susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar choleraesuis but mice lacking IL-2 are resistant.
Infect. Immun. Vol. 69 page： 1226-1229 2001
Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death.
J. Cell. Biochem. Vol. 81 page： 679-688 2001
Osmotic stress-mediated activation of RET kinases involves intracellular disulfide-bonded dimer formation.
Antioxid. Redox Signal. Vol. 3 page： 473-482 2001
Superoxide-mediated early oxidation and activation of ASK1 are important for initiating methylglyoxal-induced apoptosis process.
Free Radic. Biol. Med. Vol. 31 page： 469-478 2001
Differential roles of cytokine receptors in the development of epidermal gd T cells.
J. Immunol. Vol. 167 page： 1929-1923 2001
Cepharanthine activates caspases and induces apoptosis in Jurkat and K562 human leukemia cell lines.
J. Cell. Biochem. Vol. 82 page： 200-214 2001
T-cell-immunity-based inhibitory effects of orally administered herbal medicine juzen-taiho-to on the growth of primarily developed melanocytic tumors in RET-transgenic mice.
J. Invest. Dermatol. Vol. 117 page： 694-701 2001
Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation.
Mol. Cell. Biol. Vol. 21 page： 6851-6858 2001
Glyoxal and methylglyoxal trigger distinct signals for map family kinases and caspase activation in humanendothelial cells.
Free Radic. Biol. Med. Vol. 31 page： 20-30 2001
Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation.
Antioxid. Redox Signal. Vol. 2 page： 841-849 2000
Mercuric chloride stimulates distinct signal transduction pathway for DNA synthesis in a T-cell line, CTLL-2.
J. Cell. Biochem. Vol. 78 page： 500-508 2000
A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus.
Virology Vol. 275 page： 57-66 2000
Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase.
J. Immunol. Vol. 165 page： 4290-4297 2000
Mapping of melanoma modifier loci in RET transgenic mice.
Jpn. J. Cancer Res. Vol. 91 page： 1142-1147 2000
Methylglyoxal induces apoptosis in Jurkat leukemia T cells by activating c-Jun N-terminal kinase.
J. Cell. Biochem. Vol. 77 page： 333-344 2000
Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosinekinases.
Mol. Biol. Cell. Vol. 11 page： 93-101 2000
4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death.
J. Cell Sci. Vol. 113 page： 635-641 2000
A short peptide derived from the antisense homology box of Fas ligand induces apoptosis in anti-Fas antibody-insensitive human ovarian cancer cells.
Apoptosis Vol. 5 page： 37-41 2000
*Normal regulatory a/b T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor b in vivo.
J. Exp. Med. Vol. 190 page： 1561-1572 1999
Mercuric chloride induces increases in both cytoplasmic and nuclear free calcium ions through a protein phosphorylation-linked mechanism.
Free Radic Biol Med. Vol. 26 page： 227-231 1999
Linkage between melanocytic tumor development and early burst of Ret protein expression for tolerance induction in metallothionein-I/ret transgenic mouse lines.
Oncogene Vol. 18 page： 837-842 1999
Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-Src.
J. Cell. Biochem. Vol. 72 page： 1-7 1999
Nitric oxide controls src kinase activity through a sulfhydryl group modification-mediated Tyr-527-independent and Tyr-416-linked mechanism.
J. Biol. Chem. Vol. 274 page： 25821-25826 1999
Functional dissection of the cytoplasmic subregions of the IL-2 receptor bc chain in primary lymphocyte populations.
EMBO J. Vol. 17 page： 6551-6557 1998
Requirement of the IL-2 receptor b chain for the development of Vg3 dendritic epidermal T cells.
J. Invest. Dermatol. Vol. 110 page： 961-965 1998
The herbal medicine sho-saiko-to inhibits the growth of malignant melanoma cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulation of cyclin dependent kinases.
Int. J. Oncol. Vol. 12 page： 1321-1326 1998
nsgenic mouse model for skin malignant melanoma.
Oncogene Vol. 17 page： 1885-1888 1998
Level of HgCl2-mediated phosphorylation of intracellular proteins determines death of thymicT-lymphocytes with or without DNA fragmentation.
J. Cell. Biochem. Vol. 71 page： 243-253 1998
Abnormal development of intestinal intraepitherial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor β chain
The Journal of Experimental Medicine Vol. 185 ( 3 ) page： 499 1997
Protein kinase Ca-mediated chronic signal transduction for immunosenescence.
J. Immunol. Vol. 159 page： 2082-2084 1997
Chemical events in signal transduction.
Immunol. Today. Vol. 18 page： 362 1997
Magnitude of protein tyrosine phosphorylation-linked signals determines growth versus death of thymic T lymphocytes.
Eur. J. Immunol. Vol. 27 page： 1254-1259 1997
Mice lacking the IL-2 receptor beta chain and the regulation of T cell activation
Immunology Frontier Vol. 7 ( 2 ) page： 95-98 1997
Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 veceptor β chain deficient mice
International Immunology Vol. 9 ( 9 ) page： 1367 1997
Role for IL-15/IL-15 receptor b-chain in natural killer 1.1+ T cell receptor-ab+ cell development.
J. Immunol. Vol. 159 page： 5931-5935 1997
Differential sensitivities to hyperbaric oxygen of lymphocyte subpopulations of normal and autoimmune mice.
Immunol. Lett. Vol. 59 page： 79-84 1997
Mice lacking interleukin-2 receptor β chain
Experimental Medicine Vol. 14 ( 3 ) page： 75 1996
Evidence of a novel redox-linked activation mechanism for the Src kinase which is independent of tyrosine 527-mediated regulation.
Oncogene Vol. 13 page： 2615-2622 1996
T細胞の活性化とその制御-インターロイキン２受容体β鎖ノックアウトマウスを用いた解析
現代医学 Vol. 44 ( 2 ) page： 357-363 1996
Disorders in mice disrupted with IL-2 receptor β chain
Clinical Immunology Vol. 28 page： 711 1996
Mercuric chloride mediates a protein sulfhydryl modification-based pathway of signal transduction for activating Src kinase which is independent of the phosphorylation/dephosphorylation of a carboxyl terminal tyrosine.
J. Cell. Biochem. Vol. 63 page： 104-114 1996
Deregulated T cell activation and autoimmunity in mice lacking Interleukin-2 receptor β
Science Vol. 268 page： 1472 1995
A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1.
Leukemia Vol. 8 page： 236-244 1994
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development.
Cell Vol. 75 page： 83-97 1993
Preferential usage of JH2 in D-J joinings with DQ52 is determined by the primary DNA sequence and is largely dependent on recombination signal sequences
European Journal of Immunology Vol. 22 page： 2225 1992
Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase).
Eur. J. Immunol. Vol. 22 page： 235-239 1992
Preferential usage of JH2 in D-J joinings with DQ52 in murine lymphocytes
International Immunology Vol. 1 ( 6 ) page： 643 1989
免疫実験法ハンドブック
中島 泉、黒澤良和、吉開泰信、安部 良、宮坂昌之、宮島 篤、長澤丘司、岡田則子、岡田秀親、鍔田武志、高濱洋介、田沼靖一、鈴木治彦、谷口 克、稲葉カヨ、村田茂穂、田中啓二、三宅健介、南野昌信、石川博通、滝口雅文、徳久剛史、坂口志文、田平 武、林 衆治、高橋利忠、武田湖州恵、川本善之、吉田友昭、長瀬文彦、吉川和宏、上田龍三、森 尚義、加藤昌志、葛島清隆、安居院高志、横地高志、宮田敏男、稲城玲子、岩本隆司、磯部健一、田口栄一、村松壽子、村松 喬、福田敏史、高橋雅英、田口 良、Akhand Md. Anwarul Azim、朝光かおり、岡本 尚、中西 守、杜 軍、加藤 道、小寺良尚、永田 真、松田 幹、中野喜和男、高松真二、河合慶親、大澤俊彦、内田浩二、灘野大太、高部圭司、川北一人、小林 猛、花井泰三、山根 隆、新海政重（ Role： Joint author）
名古屋大学出版会 2006
Essential roles of CD8+CD122+ regulatory T cells (CD122Treg) in immune homeostasis and their application to disease. International conference
The Healthcare Technology Development Center Mini Symposium 2007
Essential roles of CD8+CD122+ regulatory T cells in immune homeostasis and their applicaton to disease International conference
Keystone Symposia
CD8+CD122+制御性T細胞の発見からその応用研究に至るまで
鈴木治彦
日本歯周病学会 第35回「若手研究者の集い」
The role of CD8Treg in maintaining immune homeostasis and their application to immune-based disorders. International conference
RCAI-JSI International Symposium
Essential roles of CD8+CD122+ regulatory T cells in immune homeostasis and their application to autoimmune disease. International conference
International Symposium:Autoimmunity in Intractable Diseases: From Bench to Clinic
CD8+細胞の活性を強く調節するCD8+CD122+制御性T細胞のがん免疫への関わり
鈴木治彦 俵功 珠玖洋
第64回日本癌学会学術総会
Essential roles of CD8+CD122+ regulatory T cells in the maintenance of immune homeostasis.
Lethally Dangerous Activation of Normal CD8+ T Cells in the Absence of CD8+CD122+ Regulatory T Cells. International conference
12th International Congress of Immunology
CD8+CD122+ regulatory T cells but not CD4+CD25+ T cells prevent the development of lethal phenotype in CD122-deficient mice. International conference
12th International Congress of Immunology
CD8+CD122+ regulatory T cells control fatally dangerous CD8+CD122- cells. International conference
Keystone Symposia
IL-2/IL-2受容体システムによる免疫応答の制御
鈴木治彦
Immunology New Wave in YOKOHAMA ‘96
Fas/FasLによる免疫記憶の制御
2016.9
ビジョナリーリサーチ助成
Grant type：Competitive
CD122の生体内全般における役割の解明
2016.8
研究助成
Grant type：Competitive
CD122は IL-2受容体のβ鎖であり、その全身ノックアウトではCD4+Tregも失われCD8+Tregの真の働きはマスクされてしまい不明である。CD4あるいはCD8のノックアウトとCD122ノックアウトを組み合わせてダブルノックアウトマウスを作り、この問題に迫る。
がん免疫でのCD8+制御性T細胞の関わりの検討
2016.4
研究開発費
Grant type：Competitive
本研究代表者が同定したCD8+制御性T細胞について、がん組織、細胞に対する免疫応答を抑える働きがあるか、あるとすればそのCD8+制御性T細胞を無力化することによって抗がん効果が現れるのか等を目標とした研究である。
CD8+制御性T細胞の新たな研究展開とそれに基づいた創薬ターゲットの探索
2012.4 - 2013.3
フィージビリティ探索タイプ
Grant type：Competitive
CD8+CD122+制御性T細胞がIL-10による抑制で働くのではなく、Fas-FasL系を利用した細胞傷害によって制御を行っていることがわかってきた。また、同CD8+制御性T細胞について、より絞り込んだ細胞集団を示すマーカーと制御の分子機構について見直しを図り、創薬ターゲットを探す目的でその制御性T細胞TCRの遺伝子クローニングを行い、CDR3領域等を含めた塩基配列決定を行った。
多発性硬化症と炎症性腸疾患におけるCD8+制御性T細胞の病態への関与の解明
2011.4 - 2015.3
医学振興助成金
Grant type：Competitive
CD8+CD122+制御性T細胞が認識する抗原分子の同定とそれを基にした研究の展開
2011.4 - 2014.3
学術研究助成
Grant type：Competitive
CD8+制御性T細胞の炎症性腸疾患への応用
2011.4 - 2013.3
学術研究助成金
Grant type：Competitive
自己免疫疾患の新たな治療薬ターゲットの探索
2011.4 - 2012.3
フィージビリティ探索タイプ
Grant type：Competitive
CD8+CD122+制御性T細胞のがん免疫への関わりの解明と同細胞を利用したがん治療法の開発
2010.4 - 2011.3
がんその他の悪性新生物研究助成
Grant type：Competitive
CD8+制御性T細胞とCD4+制御性T細胞との協調による免疫恒常性維持機構の解明
2009.4 - 2012.3
研究助成
Grant type：Competitive
CD8+CD122+制御性T細胞に選択的に発現する分子のExpression Cloning法による同定
2009.4 - 2010.3
助成金
Grant type：Competitive
CD8+制御性T細胞を利用した全身性エリテマトーデス（SLE）に対する新たな治療方法の開発
2009.4 - 2010.3
研究助成
Grant type：Competitive
CD8+CD122+制御性T細胞による免疫制御の分子機構
2008.4 - 2010.3
研究奨励
Grant type：Competitive
造血幹細胞移植におけるCD8+制御性T細胞の動態と効果
2008.4 - 2009.3
研究助成
Grant type：Competitive
ＣＤ８＋ＣＤ１２２＋制御性Ｔ細胞を利用したがん免疫療法の開発
2006
CD8+CD122+制御性T細胞による骨髄移植後の免疫応答制御の試み
2005.4 - 2007.3
一般研究賞
Grant type：Competitive
新たに同定された制御性T細胞の免疫制御における意義と制御機構の解明
2004.4 - 2005.3
研究助成
Grant type：Competitive
成熟Tリンパ球の細胞死を抑制し、生存を維持するために必要な因子とその機構についての研究
2001.4 - 2002.3
研究奨励
Grant type：Competitive
インターロイキン−２受容体β鎖依存性にT細胞の活性化を制御する細胞の同定とその制御機構についての研究
2000.4 - 2001.3
研究助成
Grant type：Competitive
活性化T細胞を増殖維持する因子についての研究
1999.4 - 2000.3
研究助成金
Grant type：Competitive
MAPKK6 (Mitogen Activated Protein Kinase Kinase6)ノックアウトマウスの作製とその解析
1998.4 - 1999.3
研究奨励
Grant type：Competitive
MAPKK6 (Mitogen Activated Protein Kinase Kinase6)ノックアウトマウスの作製とその解析
1997.4 - 1998.3
がんその他の悪性新生物研究助成
Grant type：Competitive
インターロイキン−２受容体を介さないT細胞増殖機構に関する研究
1996.4 - 1997.3
研究助成
Grant type：Competitive
Grant number：23H02813 2023.4 - 2027.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Authorship：Coinvestigator(s) Grant type：Competitive
過敏性と炎症を映す消化管興奮連携の可視化
Grant number：2619H03558 2019.4 - 2022.3
科学研究費補助金 基盤研究（B)
中山晋介
Authorship：Coinvestigator(s)
Fas/FasLと放射線ないしはGVHによる細胞傷害によって引き起こされる皮膚炎
2014.4 - 2015.3
科学研究費補助金 挑戦的萌芽研究
Authorship：Principal investigator
FasLを欠損するgldマウスの骨髄を、gldマウスの骨髄で再構築するという同系骨髄移植実験を行うとGVHD様の皮膚炎が必発で起こってくる。皮膚炎の発症にはいかなる因子が必要か、いかなる細胞が皮膚炎の発生を抑えているか、多くの異なったノックアウトマウスを用意し、その骨髄細胞とgldマウス骨髄細胞と混ぜ合わせてgldマウス骨髄を再構築するなどして検討追求した。
CD8陽性制御性T細胞を利用した炎症性腸疾患治療へのアプローチ
2008.10 - 2010.9
科学研究費補助金
Authorship：Principal investigator
マウスIBDモデルにおいてCD8+CD122+Tregが炎症の抑制に働くことを見いだした。
CD8+CD122+制御性T細胞を利用したがん免疫療法の開発
2006.4 - 2007.3
科学研究費補助金 特定領域研究
鈴木治彦
Authorship：Principal investigator
マウスの実験系において、CD8+CD122+制御性T細胞が抗腫瘍免疫応答をも制御していることがわかり、同制御性細胞の活性を抑えることががんの治療につながる可能性を見いだした。
新規制御性T細胞の自己免疫疾患への関わりの解明と同細胞の骨髄移植への適用
2005.10 - 2007.9
科学研究費補助金
鈴木治彦
Authorship：Principal investigator
同種異系統間の骨髄移植において、CD8+CD122+制御性T細胞が移植片拒絶や移植片対宿主反応を抑制する能力を持つことを、マウスの実験系によって見いだした。
臓器移植
2020
生命科学文化推進機構
Role(s)：Editer, Planner, Organizing member
2015.4
