Updated on 2024/03/14

写真a

 
KATO, Masashi
 
Organization
Graduate School of Medicine Program in Integrated Medicine Social Life Science Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Professor
Contact information
メールアドレス

Degree 1

  1. 博士(医学) ( 1995.3   名古屋大学 ) 

Research Interests 1

  1. heavy metal, skin cancer, melanoma, SCC, hyper-pigmented skin, vitiligo, liver spots, gray hair, alopecia, fieldwork, epidemiology, remediation, arsenicosis, health risk assessment, prevention

Research Areas 5

  1. Others / Others  / 分子環境予防医学

  2. Others / Others  / Intracellular signal transduction

  3. Others / Others  / Pigment Cell Research

  4. Others / Others  / Otology

  5. Others / Others  / Allergy

Current Research Project and SDGs 4

  1. Noise and Hearing

  2. 重金属が疾患を誘導する分子機構と予防法の開発

  3. Molecular mechanism of UV-mediated skin cancer

  4. Anti-aging based on analysis for skin melanocytes

Education 2

  1. Nagoya University   Graduate School, Division of Medicine

    - 1995

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    Country: Japan

  2. Fukui Medical University   Faculty of Medicine

    - 1988

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    Country: Japan

Professional Memberships 7

  1. 日本衛生学会   理事

    2015.4

  2. 日本産業衛生学会   地方会理事

    2013.4

  3. 皮膚科学会

  4. 美容皮膚科学会

  5. 加齢皮膚医学研究会   幹事

    2010.5

  6. 専門医制度委員会   産業専門医・指導医

    2017.2

  7. 分子予防環境医学研究会

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Committee Memberships 2

  1. YLP運営委員会   副委員長  

    2023.1   

  2. YLP運営委員会   委員長  

    2013.1 - 2022.12   

Awards 7

  1. 第70回保健文化賞(厚生労働大臣賞・第一生命賞・朝日新聞厚生文化事業団賞・NHK厚生文化事業団賞)

    2018.10   第一生命保険株式会社、厚生労働省等  

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    Country:Japan

  2. H28年度 遠山椿吉記念 食と環境の科学賞

    2017.2   一般財団法人 東京顕微鏡院  

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    Award type:Award from publisher, newspaper, foundation, etc.  Country:Japan

  3. 武見奨励賞

    2014.12   公益信託 武見記念生存科学研究基金  

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    Country:Japan

  4. 日本加齢皮膚医学研究会 ロート賞

    2008.7   日本加齢皮膚医学研究会  

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    Country:Japan

  5. 日本衛生学会 奨励賞

    2006.3   日本衛生学会  

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    Country:Japan

  6. 第5回花王研究奨励賞 医学・生物学分野

    2003.6   花王芸術・科学財団  

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    Country:Japan

  7. H14年度 安江賞

    2002   東海皮膚科漢方研究会  

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    Country:Japan

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Papers 250

  1. Upregulation of IL4-induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties

    Bekkat, F; Seradj, M; Lengagne, R; Fiore, F; Kato, M; Lucas, B; Castellano, F; Molinier-Frenkel, V; Richard, Y; Prevost-Blondel, A

    EUROPEAN JOURNAL OF IMMUNOLOGY     page: e2350615   2024.2

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  2. Beneficial and adverse effects of dam construction in canal tannery wastewater effluent with a high content of chromium in Hazaribagh, Bangladesh.

    Kurniasari F, Htike MT, Tazaki A, Kagawa T, Al Hossain MMA, Akhand AA, Ahsan N, Ohnuma S, Iwasaki N, Kato M

    Chemosphere   Vol. 350   page: 141047   2024.2

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  3. Retinal ferroptosis as a critical mechanism for the induction of retinochoroiditis during ocular toxoplasmosis

    Yamada, K; Tazaki, A; Ushio-Watanabe, N; Usui, Y; Takeda, A; Matsunaga, M; Suzumura, A; Shimizu, H; Zheng, H; Ariefta, NR; Yamamoto, M; Hara, H; Goto, H; Sonoda, KH; Nishiguchi, KM; Kato, M; Nishikawa, Y; Toyokuni, S; Kaneko, H

    REDOX BIOLOGY   Vol. 67   page: 102890   2023.11

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  4. Unexpected associations of long-term and excessive exposure to trivalent chromium with hypertension and glycosuria in male tannery workers.

    Tsuchiyama T, Chen D, Al Hossain MMA, Tazaki A, Kagawa T, Gu Y, Gao Y, Kurniasari F, Ahsan N, Akhand AA, Kato M

    Chemosphere   Vol. 337   page: 139190   2023.10

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  5. Elevated arsenic level in fasting serum via ingestion of fish meat increased the risk of hypertension in humans and mice.

    Kagawa T, Ohgami N, He T, Tazaki A, Ohnuma S, Naito H, Yajima I, Chen D, Deng Y, Tamura T, Kondo T, Wakai K, Kato M

    European heart journal open   Vol. 3 ( 5 ) page: oead074   2023.9

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    Language:English  

    DOI: 10.1093/ehjopen/oead074

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  6. Efficient removal of molybdate from groundwater with visible color changes using wasted aerobic granular sludge. Invited Reviewed

    Tian Yuan, Jing Xu, Zhiwei Wang, Zhongfang Lei, Masashi Kato, Kazuya Shimizu, Zhenya Zhang

    Separation and Purification Technology   Vol. 317   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1016/j.seppur.2023.123849

  7. Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers

    Katsuta Hiroki, Okuda Satoru, Nagayama Kazuaki, Machiyama Hiroaki, Kidoaki Satoru, Kato Masashi, Sokabe Masahiro, Miyata Takaki, Hirata Hiroaki

    ISCIENCE   Vol. 26 ( 3 ) page: 106090   2023.3

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  8. Zinc deficiency is associated with the development of ovarian endometrial cysts

    Onuma Toshimichi, Mizutani Tetsuya, Fujita Yuko, Ohgami Nobutaka, Ohnuma Shoko, Kato Masashi, Yoshida Yoshio

    AMERICAN JOURNAL OF CANCER RESEARCH   Vol. 13 ( 3 ) page: 1049 - 1066   2023

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  9. Zinc deficiency is associated with the development of ovarian endometrial cysts.

    Onuma T, Mizutani T, Fujita Y, Ohgami N, Ohnuma S, Kato M, Yoshida Y

    American journal of cancer research   Vol. 13 ( 3 ) page: 1049 - 1066   2023

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  10. Vascular endothelium as a target tissue for short-term exposure to low-frequency noise that increases cutaneous blood flow

    Deng Yuqi, Ohgami Nobutaka, Kagawa Takumi, Kurniasari Fitri, Chena Dijie, Kato Masashi, Tazaki Akira, Aoki Masayo, Katsuta Hiroki, Tong Keming, Gu Yishuo, Kato Masashi

    SCIENCE OF THE TOTAL ENVIRONMENT   Vol. 851 ( Pt 1 ) page: 158828   2022.12

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  11. Potential application of a hydrotalcite-like compound for reduction of toxicity to aquatic organisms via rapid and efficient removal of hydrogen sulfide

    Yuan Tian, Hashimoto Kazunori, Tazaki Akira, Hasegawa Masahiro, Kurniasari Fitri, Ohta Chihiro, Aoki Masayo, Ohgami Nobutaka, Kato Masashi

    JOURNAL OF ENVIRONMENTAL MANAGEMENT   Vol. 321   page: 115861   2022.11

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  12. Decreased hearing levels at frequencies for understanding speech in tannery workers exposed to a high level of trivalent chromium in Bangladesh

    Gu Yishuo, Ohgami Nobutaka, Hossain M. M. Aeorangajeb Al, Tazaki Akira, Tsuchiyama Tomoyuki, He Tingchao, Aoki Masayo, Ahsan Nazmul, Akhand Anwarul Azim, Kato Masashi

    CHEMOSPHERE   Vol. 306   page: 135571   2022.11

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  13. Redistribution of potentially toxic elements in the hydrosphere after the relocation of a group of tanneries Reviewed

    Kurniasari F, Tazaki A, Hashimoto K, Yuan T, Al Hossain MMA, Akhand AA, Ahsan N, Ohnuma S, Kato M.

    Chemosphere   Vol. 303 ( 2 ) page: 135098 - 135107   2022.9

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    Authorship:Corresponding author   Language:English  

    DOI: 10.1016/j.chemosphere.2022.135098

  14. Significance of platinum distribution to predict platinum resistance in ovarian cancer after platinum treatment in neoadjuvant chemotherapy

    Uno Kaname, Yoshikawa Nobuhisa, Tazaki Akira, Ohnuma Shoko, Kitami Kazuhisa, Iyoshi Shohei, Mogi Kazumasa, Yoshihara Masato, Koya Yoshihiro, Sugiyama Mai, Tamauchi Satoshi, Ikeda Yoshiki, Yokoi Akira, Kikkawa Fumitaka, Kato Masashi, Kajiyama Hiroaki

    SCIENTIFIC REPORTS   Vol. 12 ( 1 ) page: 4513   2022.3

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  15. Calcitriol inhibits arsenic-promoted tumorigenesis through regulation of arsenic-uptake in a human keratinocyte cell line Reviewed

    Yajima I, Tazaki A, Ohgami N, Kato M.

    American Journal of Cancer Research   Vol. 12 ( 11 ) page: 5019 - 5028   2022

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    Authorship:Corresponding author  

  16. Calcitriol inhibits arsenic-promoted tumorigenesis through regulation of arsenic-uptake in a human keratinocyte cell line.

    Yajima I, Tazaki A, Ohgami N, Kato M

    American journal of cancer research   Vol. 12 ( 11 ) page: 5019 - 5028   2022

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  17. Calcitriol inhibits arsenic-promoted tumorigenesis through regulation of arsenic-uptake in a human keratinocyte cell line

    Yajima Ichiro, Tazaki Akira, Ohgami Nobutaka, Kato Masashi

    AMERICAN JOURNAL OF CANCER RESEARCH   Vol. 12 ( 11 ) page: 5019 - +   2022

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  18. Development of an efficient remediation system with a low cost after identification of water pollutants including phenolic compounds in a tannery built-up area in Bangladesh

    Yuan Tian, Tazaki Akira, Hashimoto Kazunori, Al Hossain M. M. Aeorangajeb, Kurniasari Fitri, Ohgami Nobutaka, Aoki Masayo, Ahsan Nazmul, Akhand Anwarul Azim, Kato Masashi

    CHEMOSPHERE   Vol. 280   page: 130959   2021.10

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  19. Reply Invited Reviewed

    Takumi Kagawa, Akira Tazaki , Huadong Xu, Nobutaka Ohgami, Masashi Kato

    J Allergy Clin Immunol   Vol. 148 ( 2 ) page: 655 - 656   2021.8

  20. Intranasal levels of lead as an exacerbation factor for allergic rhinitis in humans and mice

    Xu Huadong, Ohgami Nobutaka, Sakashita Masafumi, Ogi Kazuhiro, Hashimoto Kazunori, Tazaki Akira, Tong Keming, Aoki Masayo, Fujieda Shigeharu, Kato Masashi

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   Vol. 148 ( 1 ) page: 139 - +   2021.7

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  21. Intranasal levels of lead as an exacerbation factor for allergic rhinitis in humans and mice. Reviewed

    Xu H, Ohgami N, Sakashita M, Ogi K, Hashimoto K, Tazaki A, Tong K, Aoki M, Fujieda S, Kato M

    The Journal of Allergy and Clinical Immunology     page: in press   2021.3

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  22. Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome Reviewed

    Ohgami N, Iizuka A, Hirai H, Yajima I, Iida M, Shimada A, Tsuzuki T, Jijiwa M, Asai N, Takahashi M, Kato M

    Journal of Biological Chemistry   Vol. 296   page: 100389   2021

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jbc.2021.100389

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  23. Development of an efficient remediation system with a low cost after identification of water pollutants including phenolic compounds in a tannery built-up area in Bangladesh. Reviewed

    Yuan T, Tazaki A, Hashimoto K, Al Hossain MMA, Kurniasaria F, Ohgamia N, Aoki M, Ahsand N, Akhand AA, Kato M

    Chemosphere     2021

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  24. Lithium promotes malignant transformation of nontumorigenic cells in vitro. Reviewed

    Sudo M, Hashimoto K, Yoshinaga M, Azimi MD, Fayaz SH, Hamajima N, Kondo-Ida L, Yanagisawa K, Kato M

    The Science of the total environment   Vol. 744   page: 140830   2020.11

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    DOI: 10.1016/j.scitotenv.2020.140830

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  25. High levels of boron promote anchorage-independent growth of nontumorigenic cells.

    Xu H, Hashimoto K, Maeda M, Azimi MD, Fayaz SH, Chen W, Hamajima N, Kato M

    Environmental pollution (Barking, Essex : 1987)   Vol. 266 ( Pt 3 ) page: 115094   2020.11

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    DOI: 10.1016/j.envpol.2020.115094

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  26. Hair graying with aging in mice carrying oncogenic <i>RET</i>

    Iida Machiko, Tazaki Akira, Yajima Ichiro, Ohgami Nobutaka, Taguchi Nobuhiko, Goto Yuji, Kumasaka Mayuko Y., Prevost-Blondel Armelle, Kono Michihiro, Akiyama Masashi, Takahashi Masahide, Kato Masashi

    AGING CELL   Vol. 19 ( 11 ) page: e13273   2020.11

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  27. Increased levels of renal damage biomarkers caused by excess exposure to trivalent chromium in workers in tanneries.

    Tsuchiyama T, Tazaki A, Al Hossain MA, Yajima I, Ahsan N, Akhand AA, Hashimoto K, Ohgami N, Kato M

    Environmental research   Vol. 188   page: 109770   2020.9

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    DOI: 10.1016/j.envres.2020.109770

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  28. Application of a human mesoderm tissue elongation system <i>in vitro</i> derived from human induced pluripotent stem cells to risk assessment for teratogenic chemicals

    Ninomiya Hiromasa, Intoh Atsushi, Ishimine Hisako, Onuma Yasuko, Ito Yuzuru, Michiue Tatsuo, Tazaki Akira, Kato Masashi

    CHEMOSPHERE   Vol. 250   page: 126124   2020.7

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    DOI: 10.1016/j.chemosphere.2020.126124

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  29. Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water Reviewed

    Kato Masashi, Ohgami Nobutaka, Ohnuma Shoko, Hashimoto Kazunori, Tazaki Akira, Xu Huadong, Kondo-Ida Lisa, Yuan Tian, Tsuchiyama Tomoyuki, He Tingchao, Kurniasari Fitri, Gu Yishuo, Chen Wei, Deng Yuqi, Komuro Kanako, Tong Keming, Yajima Ichiro

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   Vol. 25 ( 1 ) page: 16   2020.5

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    DOI: 10.1186/s12199-020-00855-8

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  30. A new method with an explant culture of the utricle for assessing the influence of exposure to low-frequency noise on the vestibule Reviewed

    Ohgami Nobutaka, He Tingchao, Oshino-Negishi Reina, Gu Yishuo, Li Xiang, Kato Masashi

    JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES   Vol. 83 ( 5 ) page: 215 - 218   2020.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/15287394.2020.1746945

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  31. Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action Reviewed

    Takeda Kozue, Kawamoto Yoshiyuki, Nagasaki Yosuke, Okuno Yusuke, Goto Yuko, Iida Machiko, Yajima Ichiro, Ohgami Nobutaka, Kato Masashi

    AMERICAN JOURNAL OF CANCER RESEARCH   Vol. 10 ( 1 ) page: 336 - 349   2020

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  32. Hair graying with aging in mice carrying oncogenic RET Reviewed

    Iida M, Tazaki A, Yajima I, Ohgami N, Taguchi N, Goto Y, Kumasaka YM, Prevost-Blondel A, Kono M, Akiyama M, Takahashi M, Kato M

    Aging Cell     page: in press   2020

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    Authorship:Corresponding author   Language:English   Publishing type:Research paper (scientific journal)  

  33. Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action.

    Takeda K, Kawamoto Y, Nagasaki Y, Okuno Y, Goto Y, Iida M, Yajima I, Ohgami N, Kato M

    American journal of cancer research   Vol. 10 ( 1 ) page: 336 - 349   2020

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  34. A unique system that can sensitively assess the risk of chemical leukoderma by using murine tail skin

    Iida Machiko, Tazaki Akira, Deng Yuqi, Chen Wei, Yajima Ichiro, Kondo-Ida Lisa, Hashimoto Kazunori, Ohgami Nobutaka, Kato Masashi

    CHEMOSPHERE   Vol. 235   page: 713 - 718   2019.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.chemosphere.2019.06.185

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  35. Heat shock protein 70 is a key molecule to rescue imbalance caused by low frequency noise.

    Negishi-Oshino R, OhgamiN, He T, Li X, Kato M, Kobayashi M, Gu Y, Komuro K, Angelidis CE, Kato M

    Archives of Toxicology   Vol. 93 ( 11 ) page: 3219 - 3228   2019.11

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    DOI: 10.1007/s00204-019-02587-3

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  36. Histological analysis of the skin of Abca1-deleted mice: A potential model for dry skin.

    Deng Y, Ohgami N, Iida M, Tazaki A, Intoh A, Kondo-Ida L, Lu R, Tuzuki T, Yokoyama S, Kato M.

    European Journal of Dermatology   Vol. 29 ( 5 ) page: 549 - 551   2019.9

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    DOI: 10.1684/ejd.2019.3621

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  37. Chromium-mediated hyperpigmentation of skin in male tannery workers in Bangladesh

    Al Hossain A MM, Yajima I, Tazaki A, Xu H, Saheduzzaman M, Ohgami N, Ahsan N, Akhand AA, Kato M

    CHEMOSPHERE   Vol. 229   page: 611 - 617   2019.8

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    DOI: 10.1016/j.chemosphere.2019.04.112

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  38. Hearing loss in humans drinking tube well water with high levels of iron in arsenic-polluted area.

    He T, Ohgami N, Li X, Yajima I, Oshino R, Kato Y, Ohgami K, Xu Huadong, Ahsan N, Akhand AA, Kato M

    Scientific Reports   Vol. 9 ( 1 ) page: 9028   2019.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-019-45524-1

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  39. cVEMP correlated with imbalance in a mouse model of vestibular disorder.

    Negishi-Oshino R, OhgamiN, He T, Ohgami K, Li X, Kato M

    Environ Health Prev Med   Vol. 24 ( 1 ) page: 39   2019.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12199-019-0794-8

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  40. Adsorption of molybdenum by melanin

    Chen Wei, Hashimoto Kazunori, Omata Yasuhiro, Ohgami Nobutaka, Tazaki Akira, Deng Yuqi, Kondo-Ida Lisa, Intoh Atsushi, Kato Masashi

    ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE   Vol. 24 ( 1 ) page: 36   2019.5

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    DOI: 10.1186/s12199-019-0791-y

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  41. Inhibition of mast cell degranulation by melanin.

    Kawamoto Y, Kondo H, Hasegawa M, Kurimoto C, Ishii Y, Kato C, Botei T, Shinya M, Murate T, Ueno Y, Kawabe M, Goto Y, Yamamoto R, Iida M, Yajima I, Ohgami N, Kato M, Takeda K

    Biochemical Pharmacology   Vol. 163   page: 178 - 193   2019.5

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    DOI: 10.1016/j.bcp.2019.02.015

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  42. For making a declaration of countermeasures against the falling birth rate from the Japanese Society for Hygiene: summary of discussion in the working group on academic research strategy against an aging society with low birth rate.

    Nomura K, Karita K, Araki A, Nishioka E, Muto G, Iwai-Shimada M, Nishikitani M, Inoue M, Tsurugano S, Kitano N, Tsuji M, Iijima S, Ueda K, Kamijima M, Yamagata Z, Sakata K, Iki M, Yanagisawa H, Kato M, Inadera H, Kokubo Y, Yokoyama K, Koizumi A, Otsuki T

    Environmental Health and Preventive Medicine   Vol. 24 ( 1 ) page: 14   2019.3

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    DOI: 10.1186/s12199-019-0768-x

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  43. [Toward a Declaration to Address Japan's Aging Society with Low Birth Rate: Summary of the Japanese Society for Hygiene's Working Group on Academic Research Strategy against an Aging Society with Low Birth Rate].

    Nomura K, Karita K, Araki A, Nishioka E, Muto G, Iwai-Shimada M, Nishikitani M, Inoue M, Tsurugano S, Kitano N, Tsuji M, Iijima S, Ueda K, Kamijima M, Yamagata Z, Sakata K, Iki M, Yanagisawa H, Kato M, Yokoyama K, Koizumi A, Otsuki T

    Nihon eiseigaku zasshi. Japanese journal of hygiene   Vol. 74 ( 0 )   2019

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    DOI: 10.1265/jjh.18034

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  44. Improvement of balance in young adults by a sound component at 100Hz in music Reviewed

    Huadong Xu, Nobutaka Ohgami, Tingchao He, Kazunori Hashimoto, Akira Tazaki, Kyoko Ohgami, Kozue Takeda & Masashi Kato

    Scientific Report   Vol. 8 ( 1 ) page: 16894   2018.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-018-35244-3

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  45. A disadvantageous effect of adsorption of barium by melanin on transforming activity

    Omata Yasuhiro, Yoshinaga Masafumi, Yajima Ichiro, Ohgami Nobutaka, Hashimoto Kazunori, Higashimura Kaho, Tazaki Akira, Kato Masashi

    CHEMOSPHERE   Vol. 210   page: 384-391   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.chemosphere.2018.07.022

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  46. Label-Free Imaging of Melanoma with Confocal Photothermal Microscopy: Differentiation between Malignant and Benign Tissue.

    Kobayashi T, Nakata K, Yajima I, Kato M, Tsurui H

    Bioengineering (Basel, Switzerland)   Vol. 5 ( 3 )   2018.8

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    DOI: 10.3390/bioengineering5030067

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  47. Arsenic level in toenails is associated with hearing loss in humans

    Li Xiang, Ohgami Nobutaka, Yajima Ichiro, Xu Huadong, Iida Machiko, Oshino Reina, Ninomiya Hiromasa, Shen Dandan, Ahsan Nazmul, Akhand Anwarul Azim, Kato Masashi

    PLOS ONE   Vol. 13 ( 7 ) page: e0198743   2018.7

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    DOI: 10.1371/journal.pone.0198743

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  48. Increased expression level of Hsp70 in the inner ears of mice by exposure to low frequency noise

    Ninomiya Hiromasa, Ohgami Nobutaka, Oshino Reina, Kato Masashi, Ohgami Kyoko, Li Xiang, Shen Dandan, Iida Machiko, Yajima Ichiro, Angelidis Charalampos E., Adachi Hiroaki, Katsuno Masahisa, Sobue Gen, Kato Masashi

    HEARING RESEARCH   Vol. 363   page: 49-54   2018.6

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    DOI: 10.1016/j.heares.2018.02.006

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  49. A comprehensive study including monitoring, assessment of health effects and development of a remediation method for chromium pollution

    Yoshinaga Masafumi, Ninomiya Hiromasa, Al Hossain M. M. Aeorangajeb, Sudo Makoto, Akhand Anwarul Azim, Ahsan Nazmul, Alim Md. Abdul, Khalequzzaman Md., Iida Machiko, Yajima Ichiro, Ohgami Nobutaka, Kato Masashi

    CHEMOSPHERE   Vol. 201   page: 667-675   2018.6

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    DOI: 10.1016/j.chemosphere.2018.03.026

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  50. Exposure of Mice to 1,2-Dichloropropane Induces CYP450-Dependent Proliferation and Apoptosis of Cholangiocytes

    Zhang Xiao, Zong Cai, Zhang Lingyi, Garner Edwin, Sugie Shigeyuki, Huang Chinyen, Wu Wenting, Chang Jie, Sakurai Toshihiro, Kato Masashi, Ichihara Sahoko, Kumagai Shinji, Ichihara Gaku

    TOXICOLOGICAL SCIENCES   Vol. 162 ( 2 ) page: 559-569   2018.4

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    DOI: 10.1093/toxsci/kfx272

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  51. Impairment of extra-high frequency auditory thresholds in subjects with elevated levels of fasting blood glucose.

    Das A, Sumit AF, Ahsan N, Kato M, Ohgami N, Akhand AA

    Journal of otology   Vol. 13 ( 1 ) page: 29-35   2018.3

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    DOI: 10.1016/j.joto.2017.10.003

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  52. Arsenic levels in cutaneous appendicular organs are correlated with digitally evaluated hyperpigmented skin of the forehead but not the sole in Bangladesh residents. Reviewed

    Yajima I, Ahsan Nazmul, Akhand AA, Al Hossain A MM, Yoshinaga M, Ohgami N, Iida M, Oshino R, Naito M, Wakai K, Kato M.

    J Expo Sci Environ Epidemiol     2018.1

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    DOI: 10.1038/jes.2016.70.

  53. Manganese in toenails is associated with hearing loss at high frequencies in humans

    Ohgami Nobutaka, Li Xiang, Yajima Ichiro, Oshino Reina, Ohgami Kyoko, Kato Yoko, Ahsan Nazmul, Akhand Anwarul Azim, Kato Masashi

    BIOMARKERS   Vol. 23 ( 6 ) page: 533-539   2018

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    DOI: 10.1080/1354750X.2018.1458153

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  54. Inflammation drives nitric oxide synthase 2 expression by gamma delta T cells and affects the balance between melanoma and vitiligo associated melanoma

    Douguet Laetitia, Bod Lloyd, Labarthe Laura, Lengagne Renee, Kato Masashi, Couillin Isabelle, Prevost-Blondel Armelle

    ONCOIMMUNOLOGY   Vol. 7 ( 9 ) page: e1484979   2018

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    DOI: 10.1080/2162402X.2018.1484979

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  55. Label-free imaging of melanoma with confocal photothermal microscopy: Differentiation between malignant and benign tissue. Reviewed

    Kobayashi T, Nakata K, Yajima I, Kato M, Tsurui H

    Bioengineering     page: in press   2018

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    DOI: in press

  56. Arsenic levels in cutaneous appendicular organs are correlated with digitally evaluated hyperpigmented skin of the forehead but not the sole in Bangladesh residents

    Yajima Ichiro, Ahsan Nazmul, Akhand Anwarul Azim, Al Hossain M. M. Aeorangajeb, Yoshinaga Masafumi, Ohgami Nobutaka, Iida Machiko, Oshino Reina, Naito Mariko, Wakai Kenji, Kato Masashi

    JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY   Vol. 28 ( 1 ) page: 64 - 68   2018

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  57. Arsenic-mediated hyperpigmentation in skin via NF-kappa B/endothelin-1 signaling in an originally developed hairless mouse model

    Yajima Ichiro, Kumasaka Mayuko Y., Iida Machiko, Oshino Reina, Tanihata Hiroko, Al Hossain Aeorangajeb, Ohgami Nobutaka, Kato Masashi

    ARCHIVES OF TOXICOLOGY   Vol. 91 ( 11 ) page: 3507-3516   2017.11

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    DOI: 10.1007/s00204-017-1975-0

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  58. Manganese-Mediated Decrease in Levels of c-RET and Tyrosine Hydroxylase Expression In Vitro

    Kumasaka Mayuko Y., Yajima Ichiro, Ohgami Nobutaka, Ninomiya Hiromasa, Iida Machiko, Li Xiang, Oshino Reina, Tanihata Hiroko, Yoshinaga Masafumi, Kato Masashi

    NEUROTOXICITY RESEARCH   Vol. 32 ( 4 ) page: 661 - 670   2017.11

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  59. Risk assessment of neonatal exposure to low frequency noise based on balance in mice. Reviewed

    Ohgami N, Oshino R, Ninomiya H, Li X, Kato M, Yajima I, Kato M.

    Front Behav Neurosci     2017.2

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    DOI: 10.3389/fnbeh.2017.00030.

  60. Role of cytochrome P450s in male reproductive toxicity of 1-bromopropane. Reviewed

    Zong C, Zhang X, Huang C, Chang J, Garner E, Sakurai T, Kato M, Ichihara S, Ichihara G.

    Toxicol Res     page: in press   2017

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  61. IL4-induced gene 1 promotes tumor growth by shaping the immune microenvironment in melanoma. Reviewed

    Bod L, Lengagne R, Wrobel L, Ramspott JP, Kato M, Avril M-F, Castellano F, Molinier-Frenkel V, Prévost-Blondel A.

    OncoImmunology     page: in press   2017

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  62. Manganese-mediated decrease in levels of c-RET and tyrosine hydroxylase expression in vitro.

    Kumasaka MY, Yajima I, Ohgami N, Ninomiya H, Iida M, Li X, Oshino R, Tanihata H, Yoshinaga M, Kato M.

    Neurotox Res     page: in press   2017

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  63. Oral exposure to arsenic causes hearing loss in young people aged 12-29 years and in young mice.

    Li x, Ohgami N, Omata Y, Yajima I, Iida M, Oshino R, Ohnuma S, Ahsan N, Akhand AA, Kato M.

    Sci Rep     page: in press   2017

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  64. Arsenic-mediated hyperpigmented skin via NF-kappa B/Endothelin1 signaling in an originally developed hairless mouse model.

    Yajima I, Kumasaka MY, Iida M, Oshino R, Tanihata H, Al Hossain A MM, Ohgami N, Kato M.

    Arch Toxicol     page: in press   2017

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  65. Amelioration of arsenic-induced toxic effects in mice by dietary supplementation of Syzygium cumini leaf extract.

    Barai M, Ahsan N, Paul N, Hossain K, Rashid M, Abdur, Kato M, Ohgami N, Akhad AA.

    Nagoya J Med Sci     page: in press   2017

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  66. Exposure to diphtheria toxin during the juvenile period impairs both inner and outer hair cells in C57BL/6 mice.

    Konishi H, Ohgami N, Matsushita A, Kondo Y, Aoyama Y, Kobayashi M, Nagai T, Ugawa S, Yamada K, Kato M, Kiyama H.

    Neuroscience     page: in press   2017

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  67. Impairments of Inner Ears Caused by Physical Environmental Stresses.

    Ohgami N, Oshino R, Ninomiya H, Li X, Kato M

    Nihon eiseigaku zasshi. Japanese journal of hygiene   Vol. 72 ( 1 ) page: 38 - 42   2017

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    DOI: 10.1265/jjh.72.38

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  68. IL4-induced gene 1 promotes tumor growth by shaping the immune microenvironment in melanoma

    Bod Lloyd, Lengagne Ee, Wrobel Ludovic, Ramspott Jan Philipp, Kato Masashi, Avril Marie-Francoise, Castellano Flavia, Molinier-Frenkel Valerie, Prevost-Blondel Armelle

    ONCOIMMUNOLOGY   Vol. 6 ( 3 ) page: e1278331   2017

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  69. Uranium in well drinking water of Kabul, Afghanistan and its effective, low-cost depuration using Mg-Fe based hydrotalcite-like compounds. Reviewed

    Kato M, Azimi MD, Fayaz SH, Shah MD, Hoque MZ, Hamajima N, Ohnuma S, Ohtsuka T, Maeda M, Yoshinaga M.

    Chemosphere   Vol. 165   page: 27-32   2016.12

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  70. Limited effectiveness of household sand filters for removal of arsenic from well water in North Vietnam. Reviewed

    Ilmiawati C, Thang ND, Iida M, Maeda M, Ohnuma S, Yajima I, Ohgami N, Oshino R, Al Hossain A MM, Hiromasa N, Kato M.

    J Water Health   Vol. 14 ( 6 ) page: 1032-1040   2016.12

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  71. Manganese-mediated acceleration of age-related hearing loss in mice. Reviewed

    Ohgami N, Yajima I, Iida M, Li X, Oshino R, Kumasaka YM, Kato M.

    Sci Rep   Vol. 8 ( 6 ) page: 36306   2016.11

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  72. Propranolol induces a favourable shift of anti-tumor immunity in a murine spontaneous model of melanoma. Reviewed

    Wrobel LJ, Bod L, Lengagne R, Kato M, Prévost- Blondel A, Gal1 FL.

    Oncotarget   Vol. 7 ( 47 ) page: 77825-77837   2016.11

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  73. Response to the letter to the editor: Metallothionein MT2A A-5G polymorphism and the risk for chronic kidney disease and diabetes. Reviewed

    Hattori Y, Naito M, Satoh M, Nakatochi M, Naito H, Kato M, Takagi S, Matsunaga T, Seiki T, Sasakabe T, Suma S, Kawai S, Okada R, Hishida A, Hamajima N, Wakai K.

    Toxicol Sci     2016.10

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    DOI: 10.1093/toxsci/kfw205

  74. Epidemiological analysis of the association between hearing and barium in humans. Reviewed

    Ohgami N, Mitsumatsu Y, Ahsan Nazmul, Akhand AA, Li X, Iida M, Yajima I, Naito M, Wakai K, Ohnuma S and Kato M.

    J Expo Sci Environ Epidemiol   Vol. 26 ( 5 ) page: 488-93   2016.9

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  75. Importance of detoxifying enzymes in differentiating fibrotic development between SHRSP5/Dmcr and SHRSP rats. Reviewed

    Naito H, Jia X, Yetti H, Yanagiba Y, Tamada H, Kitamori K, Hayashi Y, Wang D, Kato M, Ishii A, Nakajima T.

    Environ Health Prev Med   Vol. 21 ( 5 ) page: 368-381   2016.9

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  76. Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450. Reviewed

    Zong C, Garner E, Huang C, Zhang X, Zhang L, Chang J, Toyokuni S, Hidenori I, Kato M, Sakurai T, Ichihara S, Ichihara G.

    Toxicol Lett   Vol. 258   page: 249-58   2016.9

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  77. Nitric oxide synthase 2 is involved in the pro-tumorigenic potential of γδ17 T cells in melanoma. Reviewed

    Douguet L, Bod L, Cherfils-Vicini J, Lengagne R, Labarthe L, Gilson E, Kato M, Avril M-F, Prévost-Blondel A.

    OncoImmunology   Vol. 5 ( 8 ) page: e1208878   2016.8

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  78. Metallothionein MT2A A-5G polymorphism as a risk factor for chronic kidney disease and diabetes: Cross-sectional and cohort studies. Reviewed

    Hattori Y, Naito M, Satoh M, Nakatochi M, Naito H, Kato M, Takagi S, Matsunaga T, Seiki T, Sasakabe T, Suma S, Kawai S, Okada R, Hishida A, Hamajima N, Wakai K.

    Toxicol Sci   Vol. 152 ( 1 ) page: 181-93   2016.7

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  79. Noninvasive, label-free, three-dimensional imaging of melanoma with confocal photothermal microscopy: Differentiate malignant melanoma from benign tumor tissue. Reviewed

    He J, Nan Wang N, Tsurui H, Kato M, Iida M, Kobayashi T.

    Sci Rep   Vol. 6   page: 30209   2016.7

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  80. Reply to the commentary "To Gorelenkova Miller and Mieyal (2015): Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases" by Mieyal JJ. Reviewed

    Kato M, Ninomiya H, Maeda M, Ilmiawati C, Al Hossain MMA, Yoshinaga M, Ohgami N.

    Arch Toxicol   Vol. 90   page: 1523-4   2016.6

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  81. Different biological effects of a constant dose for single UVB irradiation with different intensities and exposure times. Reviewed

    Iida M, Nakano C, Tamaki M, Hasegawa M, Tsuzuki T, Kato M.

    Exp Dermatol   Vol. 25 ( 5 ) page: 386-8   2016.5

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  82. Commentary to Gorelenkova Miller and Mieyal (2015): Sulfhydryl-mediated redox signaling in inflammation: role in neurodegenerative diseases. Reviewed

    Kato M, Ninomiya H, Maeda M, Tanaka N, Ilmiawati C, Yoshinaga M.

    Arch Toxicol   Vol. 90 ( 4 ) page: 1017-8   2016.4

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  83. Transcription factor LSF (TFCP2) inhibits melanoma growth. Reviewed

    Goto Y, Yajima I, Kumasaka M, Ohgami N, Tanaka A, Tsuzuki Toyonori, Inoue Y,Fukushima S, Ihn H, Kyoya M, Ohashi H, Kawakami T, Bennett DC and Kato M.

    Oncotarget   Vol. 7 ( 2 ) page: 2379-90   2016.1

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  84. Efficacy of Dietary Lipid Control in Healing High-fat and High-cholesterol Diet-induced Fibrotic Steatohepatitis in Rats. Reviewed

    Tamada H, Naito H, Kitamori K, Hayashi Y, Yamagishi N Kato M, Nakajima T.

    PLoS ONE   Vol. 11 ( 1 ) page: e0145939   2016.1

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  85. Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation. Reviewed

    Kawamoto Y, Ueno Y, Nakahashi E, Obayashi M, Sugihara K, Qiao S, Iida M, Yajima-Kumasaka M, Yajima I, Goto Y, Ohgami N, Kato M and Takeda K.

    J Nutr Biochem   Vol. 27   page: 112-122   2016.1

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  86. Modulated expression levels of tyrosine kinases in spontaneously developed melanoma by single irradiation of non-thermal atmospheric pressure plasmas. Reviewed

    Omata Y, Iida M, Yajima I, Ohgami N, Maeda M, Ninomiya H, Oshino R, Tsuzuki T, Hori M, Kato M.

    Int J Clin Exp Pathol     page: in press   2016

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  87. Rapid dissemination of RET-transgene driven melanoma in the presence of Non-Obese Diabetic alleles: critical roles of Dectin-1 and Nitric-Oxide Synthase type 2. Reviewed

    Dabbeche-Bouricha E, Araujo L, Kato M, Prevost-Blondel A, and Garchon H-J.

    OncoImmunology   Vol. 5 ( 5 ) page: e1100793   2015.10

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  88. Macrophage depletion reduces postsurgical tumor recurrence and metastatic growth in a spontaneous murine model of melanoma. Reviewed

    Tham M, Khoo K, Yeo KP, Kato M, Prevost-Blondel A, Angeli V, Abastado JP.

    Oncotarget   Vol. 6 ( 26 ) page: 22857-68   2015.9

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  89. Carcinogenic risk of chromium, copper and arsenic in CCA-treated woods. Reviewed

    Ohgami N, Yamanoshita O, Thang ND, Yajima I, Nakano C, Wu W, Ohnuma S, Kato M.

    Environ Pollut   Vol. 206   page: 456-60   2015.8

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  90. Decreased expression levels of cell cycle regulators and matrix metalloproteinases in melanoma from RET-transgenic mice by single irradiation of non-equilibrium atmospheric pressure plasmas. Reviewed

    Iida M, Omata Y, Nakano C, Yajima I, Tsuzuki T, Ishikawa K, Hori M, Kato M.

    Int J Clin Exp Pathol   Vol. 8 ( 8 ) page: 9326-31   2015.8

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  91. Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway. Reviewed

    Thang ND, Yajima I, Kumasaka M, Iida M, Suzuki T, Kato M.

    Oncotarget   Vol. 6 ( 16 ) page: 14290-9   2015.6

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  92. Prenatal maternal blood triglyceride and fatty acid levels, not term birth dimensions, in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study. Reviewed

    Jia X, Harada Y, Tagawa M, Naito H, Hayashi Y, Husna Y, Kato M, Sasaki S, Araki A, Miyashita C, Ikeno T, Kishi R, Nakajima T.

    Enviorn Health Prev Med   Vol. 20 ( 3 ) page: 168-78   2015.5

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  93. Arsenic-mediated promotion of anchorage-independent growth through increased level of placental growth factor. Reviewed

    Yajima I, Kumasaka MY, Ohnuma S, Ohgami N, Naito H, Shekhar HU, Omata Y, Kato M.

    J Invest Dermatol   Vol. 135 ( 4 ) page: 1147-56   2015.4

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  94. Cupper oxide nanoparticles reduce vasculogenesis in transgenic zebrafish throufg down-regulation of VEGF expression and induction of apoptosis. Reviewed

    Chang J, Ichihara G, Shimada Y, Tada-Oikawa S, Kuroyanagi J, Zhang B, Suzuki Y, Sehsah R, Kato M, Tanaka T, Ichihara S.

    J Nanosci Nanotechnol   Vol. 15 ( 3 ) page: 2140-7   2015.3

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  95. Cigarette smoking causes hearing impairment among Bangladeshi population. Reviewed

    Sumit AF, Das A, Sharmin Z, Ahsan N, Ohgami N, Kato M, Akhand AA.

    PLoS ONE   Vol. 10 ( 3 ) page: e0118960   2015.3

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    DOI: 10.1371/journal.pone.0118960

  96. Protective effects of Phyllanthus emblica leaf extract on sodium arsenite-mediated adverse effects in mice. Reviewed

    Sayed S, Ahsan N, Kato M, Ohgami N, Rashid A, Akhand AA.

    Nagoya J Med Sci   Vol. 77 ( 1-2 ) page: 145-53   2015.2

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  97. Tumor stroma and chemokines control T cell migration into melanoma following Temozolomide treatment. Reviewed

    Tan KW, Evrard M, Tham M, Hong M, Huang C, Kato M, Prevost-Blondel A, Donnadieu E, Ng LG, Abastado J-P.

    OncoImmunology   Vol. 4 ( 2 ) page: e978709   2015.2

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    DOI: 10.4161/2162402X.2014.978709

  98. Treatment of vemurafenib-resistant SKMEL-28 melanoma cells with paclitaxel. Reviewed

    Thang ND, Kumasaka YM, Nghia PT, Yajima I, Kato M.

    Asian Pac J Cancer Prev   Vol. 16 ( 2 ) page: 699-705   2015.2

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  99. Correlated expression levels of Endothelin receptor B and Plexin C1 in melanoma. Reviewed

    Kumasaka YM, Yajima I, Iida M, Takahashi H, Inoue Y, Fukushima S, Ihn H, Takeda K, Naito Y, Yoshikawa T, Kato M.

    Am J Cancer Res   Vol. 5 ( 3 ) page: 1117-23   2015.2

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  100. Plasma with high electron density and Plasma-Activated Medium for Cancer Treatment. Reviewed

    Tanaka H, Mizuno M, Ishikawa K, Kondo H, Takeda K, Hashizume H, Nakamura K, Utsumi F, Kajiyama H, Kano H, Okazaki Y, Toyokuni S, Akiyama S, Maruyama S, Yamada S, Kodera Y, Kaneko H, Terasaki H, Hara H, Adachi T, Iida M, Yajima I, Kato M, Kikkawa F, Hori M.

    Clinical Plasma Medicine     page: in press   2015

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  101. Lymphadenectomy promotes tumor growth and cancer cell dissemination in the spontaneous RET mouse model of human uveal melanoma. Reviewed

    Pin YK, Khoo K, Tham M, Karwai T, Hwee TC, Puaux A-L, Phua MLC, KatoM, Veronique A, Abastado JP.

    Oncotarget     page: in press   2015

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  102. Melanoma-Initiating Cells Exploit M2 Macrophage TGF. Reviewed

    Tham M, Tan KW, Keeble J, Wang X, Hubert S, Barron L, Tan NS, Kato M, Prevost-Blondel A, Angeli V, Abastado J-P.

    Oncotarget   Vol. 5 ( 23 ) page: 12027-42   2014.12

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  103. Synergistic effect of exposure to zinc oxide nanoparticle on inflammatory response to bleomycin-induced pulmonary fibrosis in mice. Reviewed

    Wu W, Ichihara G, Hashimoto N, Hasegawa Y, Hayashi Y, Tada-Oikawa S, Suzuki Y, Chang J, Kato M, D'Alessandro-Gabazza CN, Gabazza EC, Ichihara S.

    Int J Mol Sci   Vol. 16 ( 1 ) page: 660-76   2014.12

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  104. Commentary to Pastore et al (2014): Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors. Reviewed

    Takeda K, Kawamoto Y, Iida M, Omata Y, Zou C, Kato M.

    Arch Toxicol     2014.9

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    DOI: 10.1007/s00204-014-1399-z

  105. Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma. Reviewed

    Omata Y, Iida M, Yajima I, Takeda K, Ohgami N, Masaru Hori H, Kato M.

    Enviorn Health Prev Med   Vol. 19   page: 367-9   2014.9

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  106. The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells.

    Vegran F, Berger H, Boidot R, Mignot G, Bruchard M, Dosset M, Chalmin F, Rebe C, Derangere V, Ryffel B, Kato M, Prevost-Blondel A, Ghiringhelli F and Apetoh L

    Nature Immunology   Vol. 15   page: 758-66   2014.8

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  107. A possible role of chenodeoxycholic acid and glycine-conjugated bile acids in fibrotic steatohepatitis in a dietary rat model. Reviewed

    Jia X, Suzuki Y, Naito H, Yetti H, Kitamori K, Hayashi Y, Kaneko R, Nomura M, Yamori Y, Zaitsu K, Kato M, Ishii A, Nakajima T.

    Dig Dis Sci   Vol. 59 ( 7 ) page: 1490-501   2014.7

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  108. Effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice. Reviewed

    Iida M,Yajima I, Ohgami N, Tamura H, Takeda K, Ichihara S, Hori M, Kato M.

    Eur J Dermatol   Vol. 24 ( 3 ) page: 392-4   2014.6

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  109. Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expression levels in melanocytic tumors of RET-transgenic mice. Reviewed

    Yajima I, Iida M, Kumasaka MY, Ohgami N, Chang J, Ichihara S, Hori M, Kato M.

    Exp Dermatol   Vol. 23 ( 6 ) page: 424-5   2014.6

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  110. Bidirectional functions of arsenic as a carcinogen and an anticancer agent in human squamous cell carcinoma. Reviewed

    Thang ND, Yajima I, Kumasaka M, Kato M.

    PLoS ONE   Vol. 9 ( 5 ) page: e96945   2014.5

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    DOI: 10.1371/journal.pone.0096945

  111. Commentary to Krishna et al. (2014): Brain deposition and neurotoxicity of manganese in adult mice exposed via the drinking water.

    Kumasaka MY, Yajima I, Ohgami N, Naito H, Omata Y, Kato M.

    Arch Toxicol   Vol. 88 ( 5 ) page: 1185-6   2014.5

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  112. Actin-binding Protein, Espin: a Novel Metastatic Regulator for Melanoma. Reviewed

    Yanagishita T, Yajima I, Kumasaka M, Kawamoto Y, Tsuzuki T, Matsumoto Y, Watanabe D, Kato M.

    Mol Cancer Res   Vol. 12 ( 3 ) page: 440-6   2014.3

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  113. GNG2 inhibits invasion of human malignant melanoma cells with decreased FAK activity. Reviewed

    Yajima I, Kumasaka MY, Yamanoshita O, Zou C, Li X, Ohgami N, Kato M.

    Am J Cancer Res   Vol. 4 ( 2 ) page: 182-8   2014.3

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  114. Expression of proteins associated with adipocyte lipolysis was significantly changed in the adipose tissues of the obese spontaneously hypertensive/NDmcr-cp rat. Reviewed

    Chang J, Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Kato C, Yamada Y, Ichihara G, Kato M, Ichihara S.

    Diabetol Metab Syndr   Vol. 6 ( 1 ) page: 8   2014.1

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    DOI: 10.1186/1758-5996-6-8

  115. Inflammatory monocytes are potent anti-tumor effectors controlled by regulatory CD4+ T cells. Reviewed

    Pommier A, Delpoux A, Audemard A, Martin B, Douguet L, Lengagne R, Campion AL, Kato M, Avril MF, Auffray C, Lucas B, Prévost-Blondel A.

    Proc Natl Acad Sci USA   Vol. 110 ( 32 ) page: 13085-90   2013.8

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  116. Enhanced constitutive invasion activity in human nontumorigenic keratinocytes exposed to a low level of barium for a long time.

    Thang ND, Yajima I, Ohnuma S, Ohgami N, Kumasaka MY, Ichihara G, Kato M.

    Envion Toxicol     2013.6

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    DOI: 10.1002/tox.21881

  117. Comparison of barium and arsenic concentrations in well drinking water and in human body samples and a novel remediation system for these elements in well drinking water

    Kato M, Kumasaka YM, Ohnuma S, Furuta A, Kato Y, Shekhar HU, Kojima M, Koike Y, Thang ND, Ohgami N, Ly TB, Jia X, Yetti H, Naito H, Ichihara G, Yajima I

    PLoS ONE   Vol. 8 ( 6 )   2013.6

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    DOI: 10.1007/s00204-012-0964-6

  118. Cyclophosphamide promotes chronic inflammation-dependent immunosuppression and prevents anti-tumor response in melanoma

    Sevko A, Sade-Feldman M, Kanterman J, Michels T, Falk C, Ramacher M, Kato M,

    J Invest Dermatol   Vol. 133 ( 6 ) page: 1610-1619   2013.6

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  119. Difference in urinary arsenic metabolites of diabetic and non-diabetic subjects in Bangladesh

    Nizam S, Kato M, Yatsuya H Khalequzzaman Md, Ohnuma S, Naito H, Nakajima T

    Int J Environ Res Public Health   Vol. 10 ( 3 ) page: 1006-19   2013.3

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  120. Anti-tumor Effect of Paclitaxel is Mediated by Inhibition of MDSCs and Chronic Inflammation in the Spontaneous Melanoma Model

    Sevko A, Michels T, Vrohlings M, Umansky L, Beckhove P, Kato M, Shurin GV, Shurin MR, Umansky V

    J Immunol   Vol. 190 ( 5 ) page: 2464-71   2013.3

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  121. Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water.

    Kumasaka YM, Yamanoshita O, Shimizu S, Ohnuma S, Furuta A, Yajima I, Nizam S, Khalequzzaman M, Shekhar UH, Nakajima T, Kato M.

    Arch Toxicol   Vol. 87 ( 3 ) page: 439-47   2013.3

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  122. Hearing impairments caused by genetic and environmental factors.

    Ohgami N, Iida M, Yajima I, Tamura H, Ohgami K, Kato M.

    Environ Health Prev Med   Vol. 18 ( 1 ) page: 10-5   2013.1

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  123. Tumor-Expressed Inducible Nitric Oxide Synthase Controls Induction of Functional Myeloid-Derived Suppressor Cells through Modulation of Vascular Endothelial Growth Factor Release.

    Jayaraman P, Parikh F, Lopez-Rivera E, Hailemichael Y, Clark A, Ma G, Cannan D, Ramacher M, Kato M, Overwijk WW, Chen SH, Umansky VY, Sikora AG

    J Immunol   Vol. 188 ( 11 ) page: 5365-76   2012.6

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  124. Cancer-Induced Immunosuppression: IL-18-Elicited Immunoablative NK Cells.

    Terme M, Ullrich E, Aymeric L, Meinhardt K, Coudert JD, Desbois M, Ghiringhelli F, Viaud S, Ryffel B, Yagita H, Chen L, Mécheri S, Kaplanski G, Prévost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Degli-Esposti M, Chaput N, Zitvogel L

    Cancer Res   Vol. 72 ( 1 ) page: 2757-67   2012.6

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  125. Barium inhibits arsenic-mediated apoptotic cell death in human squamous cell carcinoma cells.

    Yajima I, Uemura N, Nizam S, Khalequzzaman M, Thnag ND, Kumasaka YM, Akhand AA, Shekhar HU, Nakajima T, Kato M

    Arch Toxicol   Vol. 86 ( 6 ) page: 961-73   2012.6

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  126. A novel hairless mouse model for malignant melanoma.

    Thang ND, Yajima I, Nakagawa K, Tsuzuki T, Kumasaka YM, Ohgami N, Thuy LB, Iwamoto T, Watanabe D, Kato M

    J Dermatol Sci   Vol. 65 ( 3 ) page: 207-12   2012.3

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  127. Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice.

    Ohgami N, Ida-Etoh M, Sakashita N, Sone M, Nakashima N, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M

    Neurobiol Aging   Vol. 33 ( 3 ) page: 626.e25-34   2012.3

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  128. Functional analysis of GNG2 in human malignant melanoma cells.

    Yajima I, Kumasaka YM, Tamura H, Ohgami N, Kato M

    J Dermatol Sci   Vol. 68 ( 3 ) page: 172-8   2012.1

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  129. Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice

    Tamura H, Ohgami N, Yajima I, Iida M, Ohgami K, Fujii N, Itabe H, Kusudo T, Yamashita H, Kato M

    PLoS ONE   Vol. 7 ( 6 ) page: e39807   2012

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  130. Reduced GNG2 expression levels in mouse malignant melanomas and human melanoma cell lines.

    Yajima I, Kumasaka YM, Naito Y, Yoshikawa T, Takahashi H, Funasaka Y, Suzuki T, Kato M

    Am J Cancer Res   Vol. 2 ( 3 ) page: 322-329   2012

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  131. c-Ret-mediated hearing losses

    Ohgami N, Ida M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M

    Proc Natl Acad Sci USA   Vol. 107 ( 29 ) page: 13051-6   2012

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  132. RAS/RAF/MEK/ERK and PI3K/PTEN/AKT signaling in malignant melanoma progression and therapy

    Yajima I, Kumasaka YM, Thang ND, Goto Y, Takeda K, Yamanoshita O, Iida M, Ohgami N, Tamura H, Kawamoto Y, Kato M

    Dermatol Res Prac   Vol. 2012   page: 354191   2012

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  133. c-Ret-mediated hearing losses

    Ohgami N, Tamura H, Ohgami K, Iida M, Yajima I, Kumasaka YM, Goto Y, Sone M, Nakashima T, Kato M

    Int J Clin Exp Pathol   Vol. 5 ( 1 ) page: 23-8   2012

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  134. Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T cell infiltration and tumor control.

    Hong M, Puaux AL, Huang C, Loumagne L, Tow C, Mackay C, Kato M, Prevost-Blondel A, Avril MF, Nardin A, Abastado JP

    Cancer Res   Vol. 71 ( 22 ) page: 6997-7009   2011.11

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  135. Chronic inflammation promotes myeloid-derived suppressor cell activation blocking antitumor immunity in transgenic mouse melanoma model.

    Meyer C, Sevko A, Ramacher M, Bazhin AV, Falk C, Osen W, Borrello I, Kato M, Schadendorf D, Baniyash M, Umansky V

    Proc Natl Acad Sci USA   Vol. 108 ( 41 ) page: 17111-6   2011.10

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  136. Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor.

    Toh B, Wang X, Keeble J, Sim WJ, Khoo K, Wong WC, Kato M, Prevost-Blondel A, Thiery JP, Abastado JP

    PLoS Biol   Vol. 9 ( 9 ) page: e1001162   2011.9

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  137. Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury.

    Furukawa A, Kawamoto Y, Chiba Y, Takei S, Hasegawa-Ishii S, Kawamura N, Yoshikawa K, Hosokawa M, Oikawa S, Kato M, Shimada A

    Neurobiol Dis   Vol. 43 ( 3 ) page: 706-14   2011.9

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  138. Requirement of endothelin receptor B expressed in spiral ganglion neurons for postnatal development of hearing.

    Ida-Eto M, Ohgami N, Iida M, Yajima I, Kumasaka MY, Takaiwa K, Kimitsuki T, Sone M, Nakashima T, Tsuzuki T, Komune S, Yanagisawa M, Kato M

    J Biol Chem   Vol. 286 ( 34 ) page: 29621-6   2011.8

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  139. IL-18 induces PD-1-dependent immunosuppression in cancer.

    Terme M, Ullrich E, Aymeric L, Meinhardt K, Desbois M, Delahaye N, Viaud S, Ryffel B, Yagita H, Kaplanski G, Prévost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Chaput N, Zitvogel L

    Cancer Res   Vol. 71 ( 16 ) page: 5393-9   2011.8

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  140. Sunlight exposure-mediated DNA damage in young adults.

    Kato M, Iida M, Goto Y, Kondo T, Yajima I

    Cancer Epidemiol Biomaker Prevent   Vol. 20 ( 8 ) page: 1622-8   2011.8

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  141. BMP-4 down-regulates the expression of Ret in murine melanocyte precursors.

    Kawakami T, Kumasaka M, Kato M, Mizoguchi M, Soma Y

    J Dermatol Sci   Vol. 63 ( 1 ) page: 66-9   2011.7

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  142. L-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects.

    Kato M, Kumasaka MY, Takeda K, Hossain K, Iida M, Yajima I, Goto Y, Ohgami N

    Toxcol In Vitro   Vol. 25   page: 623–629   2011.4

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  143. Effects of light smoking on extra-high-frequency auditory thresholds in young adults

    Ohgami N, Kondo T, Kato M

    Toxicol Ind Health   Vol. 27   page: 143-147   2011.3

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  144. Molecular network associated with MITF on skin melanoma development and progression.

    Yajima I, Kumasaka YM, Thang ND, Goto Y, Takeda K, Iida M, Ohgami N, Tamura H, Yamanoshita O, Kawamoto Y, Furukawa K, Kato M

    J Skin Cancer   Vol. 2011   page: 730170   2011

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  145. Antioxidative effects of cherry leaves extract on tert-butyl hydroperoxide-mediated cytotoxicity through regulation of thioredoxin-2 protein expression level.

    Taguchi N, Uemura N, Goto Y, Sakura M, Hara K, Niwa M, Iida M, Yanagishita T, Watanabe D, Kato M

    J Toxicol Environ Health A   Vol. 74 ( 18 ) page: 1240-7   2011

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  146. Control of Genetically Designed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions

    Nakashima I, Kawamoto Y, Takeda K, Kato M

    Enzyme Res   Vol. 10   page: 896567   2011

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  147. T Cells Contribute to Tumor Progression by Favoring Pro-Tumoral Properties of Intra-Tumoral Myeloid Cells in a Mouse Model for Spontaneous Melanoma

    Lengagne R, Pommier A, Caron J, Douguet L, Garcette M, Kato M, Avril M-F, Abastado J-P, Bercovici N, Lucas B and Prevost-Blondel A

    PLoS ONE   Vol. 6 ( 5 ) page: e20235   2011

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  148. c-Ret-mediated hearing loss in mice with Hirschsprung disease.

    Ohgami N, Ida M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K,

    Proc Natl Acad Sci USA   Vol. 107 ( 29 ) page: 13051-6   2010.7

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  149. Targeting Surface Nucleolin with a Multivalent Pseudopeptide Delays Development of Spontaneous Melanoma in RET Transgenic Mice.

    Khoury DE, Destouches D, Lengagne R, Krust B, Hamma-Kourbali Y, Garcette M, Niro S, Kato M, Briand J-P, Courty J, Hovanessian AG, Prévost-Blondel A

    BMC Cancer   Vol. 10   page: 325   2010.6

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  150. c-Ret-mediated hearing loss in mice with Hirschsprung disease. Reviewed

    Ohgami N, Ida M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M.

    Proc Natl Acad Sci USA   Vol. 107 ( 29 ) page: 13051-6   2010.6

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  151. Tumor cells disseminate early but immunosurveillance limits metastatic outgrowth in a mouse model of melanoma.

    Eyles J, Puaux A, Wang J, Toh B, Prakash C, Hong M, Zheng L, Ong LC, Jin Y, Kato M, Blondel AP, Chow P, Yang H, Abastado J-P

    J Clin Invest   Vol. 120 ( 6 ) page: 2030-9   2010.6

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  152. A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation

    Kato M, Takeda K, Hossain K, Thang D. Nguyen, Kaneko Y, Kumasaka M, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y

    J Cell Biochem   Vol. 110   page: 399-407   2010.5

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  153. c-RET molecule in malignant melanoma from oncogenic RET-carrying transgenic mice and human cell lines

    Ohshima Y, Yajima I, Takeda K, Iida M, Kumasaka M, Matsumoto Y, Kato M

    PLoS ONE   Vol. 5 ( 4 ) page: e10279   2010.4

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  154. Ergün S and Schadendorf D: Resistance to anti-angiogenic therapy is directed by vascular phenotype, vessel stabilization and maturation in malignant melanoma.

    Helfrich I, Scheffrahn I, Bartling S, Weis J, von Felbert V, Middleton M, Kato M

    J Exp Med   Vol. 207 ( 3 ) page: 491-503   2010.3

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  155. Increased CD109 expression levels in human malignant melanoma

    Ohshima Y, Yajima I, Kumasaka YM, Yanagishita T, Watanabe D, Takahashi M, Inoue Y, Ihn H, Matsumoto Y, Kato M

    J Dermatol Sci   Vol. 57 ( 2 ) page: 140-2   2010.2

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  156. A Novel Mouse Model for de novo melanoma

    Kumasaka YM, Yajima I, Hossain K, Iida M, Tsuzuki T, Ohno T, Takahashi M, Yanagisawa M, Kato M

    Cancer Res   Vol. 70 ( 1 ) page: 24-9   2010.1

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  157. Toxic Elements in Well Water from Malaysia

    Kato M, Ohnuma S, Kato Y, Thang D. Nguyen, Yajima I, Hoque Z. Mohammad, Shekhar U. Hossain

    Toxicol Environ Chem   Vol. 92 ( 9 ) page: 1609-12   2010

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  158. 1,4-butanediyl-bismethanethiosulfonate (BMTS) induces reactive oxygen species-mediated apoptotic signals independent of stress-activated MAPK cascade in Jurkat cells.

    Hossain K, Kawamoto Y, Hamada M, Akhand A, Yanagishita T, Hoque Md. A, Tsuboi H, Kato M, Nakashima I

    J Cell Biochem   Vol. 108 ( 5 ) page: 1059-65   2009.12

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  159. Skin Melanoma Development in Ret Transgenic Mice Despite the Depletion of CD25+FoxP3+ Regulatory T-Cells in Lymphoid Organs.

    Kimpfler S, Ring S, Falk C, Osen W, Kato M, Mahnke K, Schadendorf D, Umansky V

    J Immunol   Vol. 183 ( 10 ) page: 6330-7   2009.11

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  160. Mendelsohn C, Costantini F: Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis.

    Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M

    Dev Cell   Vol. 17 ( 2 ) page: 199-209   2009.8

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  161. Activation of p38 MAPK Drives Dendritic Cells to Become Tolerogenic in Ret Transgenic Mice Spontaneously Developing Melanoma.

    Zhao F, Falk C, Osen W, Kato M, Schadendorf D, Umansky V

    Clin Cancer Res   Vol. 15 ( 13 ) page: 4382-90   2009.7

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  162. Zinc finger protein 28 as a novel melanoma-related molecule.

    Yajima I, Kumasaka M, Thang ND, Yanagishita T, Ohgami N, Kallenberg D, Naito Y, Yoshikawa T, Sakashita N, Kato M.

    J Dermatol Sci   Vol. 55 ( 1 ) page: 68-70   2009.7

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  163. NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.

    Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, a Ruggeri L, Capanni M, Umansky V, Paschen A, Sucker A, Pende D, Groh V, Biassoni R, Höglund P, Kato M, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, Kärre K, Shibuya A, Carbone E, Colucci F.

    J Clin Invest   Vol. 119 ( 5 ) page: 1251-63   2009.5

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  164. Melanoma Specific Memory T Cells Are Functionally Active in Ret Transgenic Mice Without Macroscopical Tumors.

    Umansky V, Abschuetz O, Osen W, Ramacher M, Zhao F, Kato M

    Cancer Res   Vol. 68 ( 22 ) page: 9451-8   2008.11

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  165. BMP-4 Upregulates Kit Expression in Mouse Melanoblasts prior to the Kit-Dependent Cycle of Melanogenesis.

    Kawakami T, Kimura S, Kawa Y, Kato M, Mizoguchi M, Soma Y

    J Invest Dermatol   Vol. 128 ( 5 ) page: 1220-6   2008.5

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  166. Distinct role for CD8 T cells toward cutaneous tumors and visceral metastases.

    Lengagne R, Graff-Dubois S, Garcette M, Renia L, Kato M, Guillet J, Engelhard HV, Avril M, Abastado J and Prévost-Blondel A

    J Immunol   Vol. 180 ( 1 ) page: 130-7   2008.1

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  167. Arsenic enhances matrix metalloproteinase-14 expression in fibroblasts.

    Kato M, Hossain K, Iida M, Sato H, Uemura N, Goto Y

    J Toxicol Environ Health A   Vol. 71 ( 16 ) page: 1053-5   2008

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  168. Protective Effect of Hyperpigmented Skin on Ultraviolet-Mediated Cutaneous Cancer Development.

    Kato M, Ohgami N, Kawamoto Y, Tsuzuki T, Hossain K, Yanagishita T, Ohshima Y, Tsuboi H, Yamanoshita O, Matsumoto Y, Takahashi M, Nakashima I

    J Invest Dermatol   Vol. 127 ( 5 ) page: 1244-9   2007.5

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  169. Novel hairless RET-transgenic mouse line with melanocytic nevi and anagen hair follicles.

    Kato M, Takeda K, Kawamoto Y, Tsuzuki T, Kato Y, Ohno T, Hossain K, Iftakhar-E-Khuda I, Ohgami N, Isobe K, Takahashi M, Nakashima I

    J Invest Dermatol   Vol. 126 ( 11 ) page: 2547-50   2006.11

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  170. A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities.

    Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H, Isobe K, Nakashima I

    FEBS Letters   Vol. 580   page: 839-43   2006.2

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  171. 5-aminolaevulinic acid photodynamic therapy in a transgenic mouse model of skin melanoma.

    Córdoba F, Braathen LR, Weissenberger J, Vallan C, Kato M, Nakashima I, Weis J,

    Exp Dermatology   Vol. 14   page: 429-37   2005.6

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  172. Interleukin-6 gene ablation in a transgenic mouse model of malignant skin melanoma.

    von Felbert V, Cordoba F, Weissenberger J, Vallan C, Kato M, Nakashima I,

    Am J Pathol   Vol. 166   page: 831-41   2005.3

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  173. Redox control of catalytic activities of membrane-associated protein tyrosine kinases.

    Nakashima I, Takeda K, Kawamoto Y, Okuno Y, Kato M, Suzuki H

    Arch Biochem Biophys   Vol. 434   page: 3-10   2005.2

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  174. A novel RFP-RET transgenic mouse model with abundant eumelanin in the cochlea.

    Hayashi H, Sone M, Ito S, Wakamatsu K, Kato M, Nakashima I and Nakashima T

    Hear Res   Vol. 195   page: 35-40   2004.9

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  175. Identification of RET Autophosphorylation Sites by Mass Spectrometry.

    J Biol Chem

    J Biol Chem   Vol. 279   page: 14213-14224   2004.4

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  176. Spontaneous vitiligo in an animal model for human melanoma: Role of tumorspecific CD8+ T cells.

    Lengagne R, Le Gal F-A, Garcette M, Fiette L, Ave P, Kato M, Briand J-P, Massot C, Nakashima I, Rénia L, Guillet J-G, Prévost-Blondel A

    Cancer Res   Vol. 64   page: 1496-501   2004.2

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  177. c-Kit-targeting immunotherapy for hereditary melanoma in a mouse model.

    Kato M, Takeda K, Kawamoto Y, Tsuzuki T, Hossain K, Tamakoshi A, Kunisada T, Kambayashi Y, Ogino K, Takahashi M, Nakashima I

    Cancer Res   Vol. 64   page: 801-806   2004.2

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  178. Formation of Superoxide Anion during Ferrous Ion-Induced Decomposition of Linoleic Acid Hydroperoxide under Aerobic Conditions.

    Kambayashi Y, Tero-Kubota S, Yamamoto Y, Kato M, Nakano M, Yagi K, Ogino K.

    J Biochem   Vol. 34   page: 903-909   2003.12

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  179. IgA1 molecules produced by tonsillar lymphocytes are under-O-glycosylated in IgA nephropathy.

    Horie A, Hiki Y, Odani H, Yasuda Y, Takahashi M, Kato M, Iwase H, Kobayashi Y, Nakashima I, Maeda K

    Am J Kidney Dis   Vol. 42   page: 486-96   2003.9

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  180. 4-Hydoroxynonenal triggers multistep signal transduction cascades for supression of cellular functions.

    Nakashima I, Liu W, Akhand AA, Takeda K, Kawamoto K, Kato M, Suzuki H

    Mol Aspects Med   Vol. 24   page: 231-238   2003.8

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  181. Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal.

    Liu W, Akhand AA, Takeda K, Kawamoto Y, Itoigawa M, Kato M, Suzuki H,

    Cell Death Differ   Vol. 10   page: 772-81   2003.7

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  182. Vam10p Defines a Sec18p-independent Step of Priming which allows Yeast Vacuole Tethering.

    Kato M and Wickner W

    Proc Natl Acad Sci USA   Vol. 100   page: 6398-6403   2003.5

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  183. Caspase activation is accelerated by the inhibition of arsenite-induced, membrane rafts-dependent Akt activation.

    Hossain K, Akhand AA, Kawamoto Y, Du J, Takeda K, Wu J, Yoshihara M, Tsuboi H, Kato M, Suzuki H, Nakashima I

    Free Radic Biol Med   Vol. 34   page: 598-606   2003.3

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  184. Redox control of T cell death.

    Nakashima I, Suzuki H, Akhand AA, Kato M

    Antioxid Redox Signal   Vol. 4 ( 3 ) page: 353-356   2002.6

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  185. Redox-Linked Signal Tansduction Pathways for Protein Tyrosine Kinase Activation.

    Nakashima I, Kato M, Akhand AA, Suzuki H, Takeda K, Hossain K, Kawamoto Y

    Antioxid Redox Signal   Vol. 4 ( 3 ) page: 517-531   2002.6

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  186. Redox-linked cell surface-oriented signaling for T-cell death.

    Akhand AA, Du J, Liu W, Hossain K, Miyata T, Nagase F, Kato M, Suzuki H, Nakashima I

    Antioxid Redox Signal   Vol. 4 ( 3 ) page: 445-454   2002.6

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  187. Repair by Src Kinase of Function-impaired RET with Multiple Endocrine Neoplasia Type 2A Mutation with Substitutions of Tyrosines in the COOH-Terminal Kinase Domain for Phenylalanine.

    Kato M, Takeda K, Kawamoto Y, Iwashita T, Akhand AA, Senga T, Yamamoto M, Sobue G, Hamaguchi M, Takahashi M and Nakashima I

    Cancer Res   Vol. 62 ( 8 ) page: 2414-22   2002.4

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  188. Evidence of Both Extra- and Intracellular Cysteine Targets of Protein Modification for Activation of RET Kinase.

    Akhand AA, Ikeyama T, Akazawa S, Kato M, Hossain K, Takeda K, Suzuki H, Takahashi M, Nakashima I

    Biochem Biophys Res Commun   Vol. 292 ( 4 ) page: 826-31   2002.4

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  189. Genomics Analysis of Homotypic Vacuole Fusion.

    Seely S, Kato M, Margolis N, Wickner W, Eitzen G.

    Mol Biol Cell   Vol. 13 ( 3 ) page: 782-794   2002.3

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  190. Glyoxal and methylglyoxal induce lyoxal and methyglyoxal induce aggergation and inactivation of ERK in human endothelial cells.

    Akhand AA, Hossain K, Kato M, Miyata T, Du J, Suzuki H, Kurokawa K, Nakashima I

    Free Radic Biol Med   Vol. 31 ( 10 ) page: 1228-1235   2001.11

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  191. RET tyrosine kinase enhances hair growth in association with promotion of melanogenesis.

    Kato M, Takeda K, Kawamoto Y, Tuzuki T, Dai Y, Nakayama S, Toriyama K, Tamada Y, Takahashi M, Nakashima I

    Oncogene   Vol. 20 ( 51 ) page: 7536-7541   2001.11

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  192. T-cell Immunity-based Inhibitory Effects of Orally Administered Herbal Medicine Juzen-taiho-to on the Growth of Primarily Developed Melanocytic Tumors in RET-Transgenic Mice.

    Dai Y, Kato M, Takeda K, Kawamoto Y, Akhand AA, Hossain K, Suzuki H, and Nakashima I.

    J Invest Dermatol   Vol. 117 ( 3 ) page: 694-701   2001.9

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  193. Preserved phosphorylation of RET receptor protein in spinal motor neurons of patients with amyotrophic lateral sclerosis: an immunohistochemical study by a phosphorylation-specific antibody at tyrosine 1062.

    Yamamoto M, Li M, Mitsuma N, Ito S, Kato M, Takahashi M and Sobue G

    Brain Res   Vol. 912 ( 1 ) page: 89-94   2001.8

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  194. Ergosterol is required for the Sec18/ATP-dpendent priming step of homotypic vacuole fusion.

    Kato M and Wickner W

    EMBO J   Vol. 20 ( 15 ) page: 4035-4040   2001.8

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  195. Distinct Involvement of NF-kappaB and p38 Mitogen-activated Protein Kinase Pathways in Serum Deprivation-mediated Stimulation of Inducible Nitric Oxide Synthase and Its Inhibition by 4-hydroxynonenal.

    Liu W, Kato M, Itoigawa M, Murakami H, Yajima M, Wu J, Ishikawa N, Nakashima I

    J Cell Bichem   Vol. 83 ( 2 ) page: 271-280   2001.8

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  196. Glyoxal and methylglyoxal trigger distinct signals for MAP family kinases and caspase activation in human endothelial cells.

    Akhand AA, Hossain K, Mitsui H, Kato M, Miyata T, Inagi R, Du J, Takeda K, Kawamoto Y, Suzuki H, Kurokawa K and Nakashima I

    Free Rad Biol Med   Vol. 31 ( 1 ) page: 20-30   2001.7

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  197. Osmotic stress-mediated activation of RET kinases involves intracellular disulfide-bonded dimer formation.

    Takeda K, Kato M, Wu J, Iwashita T, Suzuki H, Takahashi M and Nakashima I

    Antioxid Redox Signal   Vol. 3 ( 3 ) page: 473-482   2001.6

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  198. Cepharanthine Activates Caspases and Induces Apoptosis in Jurkat and K562 Human Leukemia Cell Lines.

    Wu J, Suzuki H, Zhou YW, Liu W, Yoshihara M, Kato M, Akhand AA, Hayakawa A, Takeuchi K, Hossain K, Kurosawa M and Nakashima I

    J Cell Biochem   Vol. 82 ( 2 ) page: 200-214   2001

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  199. Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death.

    Takeuchi K, Kato M, Suzuki H, Akhand AA, Wu J, Hossain K, Miyata T, Matsumoto Y, Nimura Y, Nakashima I.

    J Cell Biochem   Vol. 81 ( 4 ) page: 679-88   2001

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  200. Ultraviolet Radiation Induces Both Full Activation of Ret Kinase and Malignant Melanocytic Tumor Promotion in RFP-RET-Transgenic Mice.

    Kato M, Liu W, Akhand AA, Hossain K, Takeda K, Takahashi M and Nakashima I

    J Invest Dermatol   Vol. 115 ( 6 ) page: 1157-1158   2000.12

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  201. Mapping of melanoma modifier loci in Ret transgenic mice.

    Dragani TA, Peissel B, Zanesi N, Aloisi A, Dai Y, Kato M, Suzuki H, Nakashima I

    Jpn J Cancer Res   Vol. 91 ( 11 ) page: 1142-7   2000.11

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  202. Arsenite induces apoptosis of murine T lymphocytes through membrane rafts- linked signaling for activation of c-Jun amino terminal kinase1.

    Hossain K, Akhand AA, Kato M, Du J, Takeda K, Wu J, Takeuchi K, Liu W, Suzuki H and Nakashima I

    J Immunol   Vol. 165 ( 8 ) page: 4290-4297   2000.10

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  203. Amount of pollen has an influence on the levels of soluble tumor necrosis factor receptors in patients with pollinosis.

    Kato M, Kato Y, Takeuchi K and Nakashima I

    Arch Otolaryngol Head Neck Surg   Vol. 126 ( 8 ) page: 997-1000   2000.8

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  204. Further characterization of the Sho-saiko-to-mediated anti-tumor effect on melanoma developed in RET- transgenic mice.

    Kato M, Isobe K, Dai Y, Liu W, Takahashi M and Nakashima I

    Invest Dermatol   Vol. 114 ( 3 ) page: 599-601   2000.3

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  205. 4-Hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death.

    Liu W, Kato M, Akhand AA, Hayakawa A, Suzuki H, Miyata T, Hotta Y, Ishikawa N and Nakashima I

    J Cell Sci   Vol. 113 ( 4 ) page: 635-641   2000.2

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  206. Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosine kinases.

    Kato M, Iwashita T, Takeda K, Akhand AA, Liu W, Yoshihara M, Asai N, Suzuki H, Takahashi M and Nakashima I

    Mol Biol Cell   Vol. 11 ( 1 ) page: 93-101   2000.1

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  207. Chemical reaction-mediated alternative signalling pathway in cells of the immune system.

    Nakashima I, Kato M, Akhand AA, Du J, Liu W, Dai Y, Suzuki H, Senga T,

    Current Trends in Immunology   Vol. 3   page: 45-58   2000

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  208. Molecular mechanism of activation and superactivation of Ret tyrosine kinases by ultraviolet light irradiation.

    Kato M, Iwashita T, Akhand AA, Liu W, Takeda K, Takeuchi K, Yoshihara M,

    Antioxid Redox Signal   Vol. 2 ( 4 ) page: 841-849   2000

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  209. Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo.

    Suzuki H, Zhou YW, Kato M, Mak TW and Nakashima I

    J Exp Med   Vol. 190 ( 11 ) page: 1561-72   1999.12

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  210. Different serum soluble Fas levels in patients with allergic rhinitis and bronchial asthma.

    Kato M, Nozaki Y, Yoshimoto T, Tamada Y, Kageyama M, Yamashita T, Kurimoto F and Nakashima I

    Allergy   Vol. 54 ( 12 ) page: 1299-1302   1999.12

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  211. Nitric oxide controls src kinase activity through a sulfhydryl group modification-mediated Tyr-527-independent and Tyr-416-linked mechanism.

    Akhand AA, Pu M, Senga T, Kato M, Suzuki H, Miyata T, Hamaguchi M and Nakashima I

    J Biol Chem   Vol. 274 ( 36 ) page: 25821-25826   1999.9

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  212. Nitric oxide controls Src Kinase activity through a redox-based molecular modification.

    Akhand AA, Pu M, Senga T, Kato M, Suzuki H, Miyata T, Hamaguchi M and Nakashima I

    J Biol Chem   Vol. 274 ( 36 ) page: 25821-25826   1999.9

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  213. Biological and biochemical properties of Ret with kinase domain mutations identified in multiple endocrine neoplasia type 2B and familial medullary thyroid carcinoma.

    Iwashita T, Kato M, Murakami H, Asai N, Ishiguro Y, Ito S, Iwata Y, Kawai K, Asai M, Kurokawa K, Kajita H and Takahashi M

    Oncogene   Vol. 18 ( 26 ) page: 3919-3922   1999.7

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  214. 4-Hydroxynonenal triggers epidermal growth factor receptor-linked signal for growth inhibition.

    Liu W, Akhand AA, Kato M, Yokoyama I, Uchida K, Miyata T, Kurokawa K and Nakashima I

    J Cell Sci   Vol. 112 ( Pt 14 ) page: 2409-2417   1999.7

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  215. Serum soluble Fas levels as a marker to distinguish allergic and non- allergic rhinitis.

    Kato M, Hattori T, Ito H, Kageyama M, Yamashita T, Nitta Y and Nakashima I

    J Allergy Clin Immunol   Vol. 103 ( 6 ) page: 1213-1214   1999.6

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  216. Elevated soluble tumor necrosis factor receptors levels in seasonal allergic rhinitis patients.

    Kato M, Hattori T, Kato Y, Matsumoto Y, Yamashita T and Nakashima I

    Allergy   Vol. 54 ( 3 ) page: 278-282   1999.3

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  217. Linkage between melanocytic tumor development and early burst of Ret protein expression for tolerance induction in metallothionein-I/ret transgenic mouse lines.

    Kato M, Liu W, Akhand AA, Dai Y, Ohbayashi M, Tuzuki T, Suzuki H, Isobe K-I, Takahashi M and Izumi Nakashima

    Oncogene   Vol. 18 ( 3 ) page: 837-842   1999.1

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  218. Carbonyl compounds cross-link cellular proteins and activate protein-tyrosine kinase p60c-Src.

    Akhand AA, Kato M, Suzuki H, Liu W, Du J, Hamaguchi M, Miyata T, Kurokawa K and Nakashima I

    J Cell Biochem   Vol. 72 ( 1 ) page: 1-7   1999.1

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  219. Differential regulation of MMP-9 and TIMP-2 expression in malignant melanoma developed in metallothionein/RET transgenic mice.

    Asai M, Kato M, Asai N, Iwashita T, Murakami H, Kawai K, Nakashima I and Takahashi M

    Jpn J Cancer Res   Vol. 90 ( 1 ) page: 86-92   1999.1

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  220. Mercuric chloride induces increases in both cytoplasmic and nuclear free calcium ions through a protein phophorylation-linked mechanism.

    Parashar A, Akhand AA, Rawar R, Furuno T, Nakanishi M, Kato M, Suzuki H and Nakashima I

    Free Radical Bio Med   Vol. 26 ( 1-2 ) page: 227-231   1999.1

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  221. Induction of T lymphocyte apoptosis by the treatment with glycyrshizing.

    Oh C, Kim Y, Eun J, Yokoyama N, Kato M and Nakashima I

    Am J Chinese Med.   Vol. 27 ( 2 ) page: 217-226   1999

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  222. Oxidative stress and signal transduction in the immune system. Recent Res Devel Immunology

    Nakashima I, Akhand AA, Kato M, Du J, Liu W, Hossain K, Suzuki H, Wu J, Takeda K, Takeuchi K and Yoshihara M

    Recent Res Devel Immunology   Vol. 1   page: 283-296   1999

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  223. Magnitude of HgCl2-mediated phosphorylation of intracellular proteins determines death of thymic T-lymphocytes with or without DNA fragmenatation.

    Akhand AA, Kato M, Suzuki H, Miyata T and Nakashima I

    J Cell Biochem   Vol. 71 ( 2 ) page: 243-253   1998.11

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  224. Transgenic Mouse Model for Skin Malignant Melanoma.

    Kato M, Takahashi M, Akhand Anwarul A, Liu W, Dai Y, Shimizu S, Iwamoto T,

    Oncogene   Vol. 17 ( 14 ) page: 1885-1888   1998.10

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  225. The herbal medicine Sho-saiko-to inhibits growth and metastasis of malignant melanoma primarily developed in ret-transgenic mice.

    Kato M, Liu W, Yi H, Asai N, Hayakawa A, Kozaki K-I, Takahashi M and Nakashima I

    J Invest Dermatol   Vol. 111 ( 4 ) page: 640-644   1998.10

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  226. Elevated soluble Fas levels in herpes zoster patients.

    Kato M, Tamada Y, Kageyama M, Yamashita T, Nitta Y, Ikeya T and Nakashima I

    Brit J Dermatol   Vol. 138 ( 6 ) page: 1091   1998.6

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  227. The herbal medicine sho-saiko-to inhibits the growth of malignant melanoma cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulation of cyclin dependent kinases.

    Liu W, Kato M, Akhand AA, Hayakawa A, Takemura M, Yoshida S, Suzuki H, and Nakashima I

    Int J Oncol   Vol. 12 ( 6 ) page: 1321-1326   1998.6

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  228. Evidence of potential regulation by interleukin 4 of the soluble intercellular adhesion molecule-1 level in patients with seasonal allergic rhinitis under provocation by a small amount of natural allergen.

    Kato M, Hattori T, Liu W and Nakashima I

    Ann Oto Rhinol Laryn   Vol. 107 ( 3 ) page: 232-235   1998.3

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  229. Protein Kinase C α-Mediated Chronic Signal Transduction for Immunosenescence.

    Ohkusu K, Du J, Isobe K, Yi H, Akhand AA, Kato M, Suzuki H, Hidaka H and Nakashima I

    J Immunol   Vol. 159 ( 5 ) page: 2082-2084   1997.9

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  230. Chemical events in signal transduction.

    Nakashima I, Pu M, Akhand AA, Kato M and Suzuki H

    Immunol Today   Vol. 18 ( 7 ) page: 362   1997.7

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  231. Magnitude of protein tyrosine phosphorlyation-linked signals determines growth versus death of thymic T lymphocytes.

    Akhand AA, Pu M, Du J, Kato M, Suzuki H, Hamaguchi M and Nakashima I

    Eur J Immunol   Vol. 27 ( 5 ) page: 1254-1259   1997.5

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  232. Enhancement of interleukin-1 alpha mediated autocrine growth of cultured human keratinocytes by Sho-saiko-to.

    Matsumoto Y, Kato M, Tamada Y and Ohashi M

    Jpn J Pharmacol   Vol. 73 ( 4 ) page: 333-336   1997.4

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  233. Differential sensitivities to hyperbaric oxygen of lymphocyte subpopulations of normal and autoimmune mice.

    Xu X, Yi H, Kato M, Suzuki H, Kobayashi S, Takahashi H and Nakashima I

    Immunol Lett   Vol. 59   page: 79-84   1997

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  234. Dynamics of soluble adhesion molecules level in the patients with pollinosis.

    Kato M, Hattori T, Matsumoto Y and Nakashima I

    Arch Otolaryngol Head Neck Surg   Vol. 122 ( 12 ) page: 1398-1400   1996.12

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  235. Evidence of a novel redox-linked activation mechanism for the Src kinase which is independent of tyrosine 527-mediated regulation.

    Pu M, Akhand AA, Kato M, Hamaguchi M, Koike T, Sabe S, Suzuki H and

    Oncogene   Vol. 13 ( 12 ) page: 2615-22   1996.12

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  236. Mercuric chloride mediates a protein sulfhydyl modification-based pathway of signal transduction for activating Src Kinase which is independent of the phosphorylation/dephosphorylation of a carboxyl terminal tyrosine

    Pu M, Akhand AA, Kato M, Koike T, Hamaguchi M, Suzuki H and Nakashima I

    J. Cell Biochem.   Vol. 63 ( 1 ) page: 104-114   1996.10

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  237. Amount of pollen has an efect on the systemic and local levels of soluble ICAM-1 in patients with seasonal allergic shinitis

    Kato M, Hattori T, Ikeda R, Yamamoto J, Yamashita T, Yanagita N and Nakashima I

    Allergy   Vol. 51 ( 2 ) page: 128-132   1996.2

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  238. Major basic protein (MBP) and topical administration of ketotifen in pollinosis under natural allergen provocation.

    Kato M, Hattori T, Kitamura M, Beppu R, Nakashima I and Yanagita N

    OLR   Vol. 57 ( 5 ) page: 269   1995.9

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  239. Multiphasic modulation of signal transduction into T lymphocytes by monoiodoacetic acid as a sulfhydryl reagent.

    Ma Li, Pu M, Yi H, Akhand AA, Ohata N, Ohkusu K, Kato M, Iwamoto T, Isobe K, Hamaguchi M and Nakashima I

    J.Cell.Biochem.   Vol. 59 ( 1 ) page: 33-41   1995.9

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  240. Soluble ICAM-1 as a regulator of nasal allergic reaction under natural allergen provocation.

    Kato M, Hattori T, Kitamura M, Beppu R, Yanagita N and Nakashima I

    Cln.Exp.Allergy   Vol. 25 ( 8 ) page: 744   1995.8

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  241. Dissociated control by glycyrrhizin of proliferation and IL-2 production of murine thymocytes.

    Zhang YH, Kato M, Isobe K, Hamaguchi M, Yokochi T and Nakashima I

    Cell Immunol.   Vol. 162 ( 1 ) page: 97-104   1995.4

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  242. Oncogene-liked in situ immunotherapy of pre-B lymphoma arising in Eu/ret transgenic mice.

    Ichihara M, Iwamoto T, Isobe K, Takahashi M, Nakayama A, Pu M, Parashar A, Ohkusu K, Kato M, Hotta T and Nakashima I

    Brit J Cancer   Vol. 71 ( 4 ) page: 808-813   1995.4

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  243. Cell type-oriented differential modulatory actions of saikosaponin-d on growth responses and DNA fragmentation of lymphocytes thymic receptor-mediated and receptor-bypassed pathways.

    Kato M, Pu M, Isobe K, Hattori T, Yanagita N, Nakashima I

    Immunopharmacology   Vol. 29 ( 3 ) page: 207   1995.4

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  244. Promotion of cytotoxic T-cell generation in mixed leukocyte culture by phosphatidylinositol-specific phospholipase C from Bacillus Thuringiensis.

    Rahman SMJ, Pu M, Hong Y, Ohkusu K, Kato M, Isobe K, Taguchi R, Ikezawa H and Nakashima I

    Infect.Immunity   Vol. 63 ( 1 ) page: 259   1995.1

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  245. Characterization of the immunoragulatory action of saikosaponin-d.

    Kato M, Pu M, Isobe K, Iwamoto T, Nagase F, Lwin T, Zhang YH, Hattori T, Yanagita N and Nakashima I

    Cell Immunal   Vol. 159 ( 1 ) page: 15-25   1994.11

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  246. Eosinophil cationic protein (ECP) and prophylactic treatment in pollinosis in natural allergen rovocation.

    Kato M, Hattori T, Takahashi M, Nakashima I and Yanagita N

    Brit.J.Cln.Pract.   Vol. 48 ( 6 ) page: 299-301   1994.11

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  247. Pathway of signal delivery to murine thymocytes triggered by co-crosslinking CD3 and thy-1 for cellular DNA fragmentation and growth inhibition.

    Nakashima I, Pu M, Hamaguchi M, Iwamoto T, Rahman SMJ, Zhang YH, Kato M,

    J.Immunol.   Vol. 151 ( 7 ) page: 3511-20   1993.10

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  248. Glycyrrhizin as a promoter of the late signal transduction for interleukin-2 production by splenic lymphocytes.

    Zhang YH, Isobe K, Nagase F, Lwin T, Kato M, Hamaguchi M and Nakashima I

    Immunology   Vol. 79 ( 4 ) page: 528-534   1993.8

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  249. T cell maturation stage-linked heterogeneity of the glycosylphosphatidylinositol membrane anchor of thy-1.

    Nakashima I, Yoshida T, Zhang YH, Pu M, Taguchi R, Ikezawa H, Isobe K, Iwamoto T,

    Immunobiol   Vol. 185 ( 5 ) page: 466-474   1992.9

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  250. Prognostic factors in squamous cell carcinoma of the larynx.

    Takahashi M, Avasarala JR, Kato M and Yanagita N

    Auris Nasus Larynx   Vol. 19   page: S127-S133   1992

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Books 8

  1. 今日の治療指針

    ( Role: Contributor ,  低周波音)

    医学書院  2022  ( ISBN:978-4-260-04282-6

  2. 発酵美容成分の開発

    田崎啓、飯田真智子、加藤昌志( Role: Joint author ,  第1章(総論)皮膚色素異常のモデル動物とリスク評価)

    シーエムシー出版  2020 

  3. Plasma medical Innovation of cancer Therapy: Melanoma

    Iida M, Omata Y, Yajima I, Sato A, Kajiwara T, Tasaka R, Hori M, Kato M( Role: Joint author)

    Plasma Medical Science, 2018  2018 

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    Language:English Book type:Textbook, survey, introduction

  4. NEW予防医学・公衆衛生学(改定第4版)

    小泉昭夫、馬場園明、今中雄一、竹林亨( Role: Contributor ,  第3章 産業衛生 化学物質による健康被害 金属)

    南江堂  2018  ( ISBN:978-4-524-25116-2

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    Responsible for pages:256-258  

  5. 色素細胞(第2版)

    山本博章, 大神信孝, 矢嶋伊知朗, 加藤昌志( Role: Joint author)

    慶応義塾大学出版会  2015 

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    Language:Japanese

  6. 悪性黒色腫の発癌機構(紫外線など環境因子との関係)

    矢嶋伊知朗, 加藤昌志( Role: Joint author)

    株式会社 日本臨床社  2013 

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    Language:Japanese

  7. モデル動物利用マニュアルシリーズ疾患モデルの作製と利用

    加藤昌志, 高橋雅英( Role: Joint author)

    株式会社 エル・アイ・シー  2012 

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    Language:Japanese

  8. 免疫実験法ハンドブック

    中島泉, 加藤昌志他( Role: Joint author)

    名古屋大学出版会  2006 

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    Language:Japanese

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Presentations 3

  1. Establishment of a spontaneously malignant melanoma-developing transgenic mouse line. International conference

    Masashi KATO

    17th International Pigment Cell Conference 

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    Event date: 1999.10 - 1999.11

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  2. 低周波音の健康影響に関する光と影 Invited

    加藤昌志

    シンポジウム「心地よい音をはかる技術・つくる技術2024」  2024.1.31 

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    Event date: 2024.1

    Presentation type:Oral presentation (invited, special)  

  3. Application of plasma irradiation to skin tumor spontaneously developed in RET-transgenic mice International conference

    The 2nd International Workshop on Plasma for Cancer Treatment 

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    Event date: 2015.3

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

Research Project for Joint Research, Competitive Funding, etc. 2

  1. 特許外国出願の支援

    2020.4 - 2021.3

    JST 知財活用支援事業 大学等知財基盤強化支援(権利化支援)  JST 知財活用支援事業 大学等知財基盤強化支援(権利化支援)

    加藤昌志、大神信孝

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    Authorship:Principal investigator  Grant type:Competitive

    Grant amount:\1000000 ( Direct Cost: \1000000 )

  2. 無意識下に健康を増進できる高付加価値空間の創造

    2018.11 - 2019.3

    JST未来社会創造事業(探索研究) 

    加藤 昌志

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    Authorship:Principal investigator  Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 11

  1. 疫学と実験研究による低周波騒音の健康障害の解明と予防法の開発

    2015.4 - 2019.3

    科学研究費補助金  基盤研究(A)

    加藤昌志

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    Authorship:Principal investigator 

  2. アジアの飲用水元素汚染に対する健康リスク評価と浄化材の開発

    2015.4 - 2019.3

    科学研究費補助金  基盤研究(A)

    加藤昌志

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    Authorship:Principal investigator 

  3. メラノーマの発症・進展を劇的に抑制できる革新的分子標的療法の開発

    2014.4 - 2017.3

    科学研究費補助金 

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    Authorship:Principal investigator 

  4. Systematic elucidation of various health disorders induced by low-frequency sound

    Grant number:23H03147  2023.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Principal investigator 

    Grant amount:\18460000 ( Direct Cost: \14200000 、 Indirect Cost:\4260000 )

  5. 皮革産業による環境汚染に起因する健康障害を解決する疫学・基礎融合研究

    Grant number:22KK0145  2022.10 - 2027.3

    科学研究費助成事業  国際共同研究加速基金(国際共同研究強化(B))

    加藤 昌志, 田崎 啓, 大神 信孝, 原 田

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    Authorship:Principal investigator 

    Grant amount:\20150000 ( Direct Cost: \15500000 、 Indirect Cost:\4650000 )

    皮革産業は世界貿易額が10兆円を越える巨大産業である。皮革製品は「クロムなめし」と「その他」に分類されるが、生産コストが低く関税が格安なので、世界の皮革製品の90%以上はクロムなめしで生産される。経済グローバル化に伴い、先進国が環境汚染・健康障害を誘発するクロムなめしの工程を途上国に押しつける構図が新たな地球規模問題をうみ出している。本研究は、皮革製品輸出国のバングラデシュ(途上国)と、主要輸入国である日本(先進国)に焦点をあて、A. 環境汚染の把握→B. 汚染物質の健康影響評価→C. 解決策の提案からなる問題解決型研究を両国が協働で実施し、本問題の解決をめざす。

  6. 元素経口曝露の健康影響をオーダーメイドで評価する新技術の開発

    Grant number:19H01147  2019.4 - 2022.3

    科学研究費助成事業  基盤研究(A)

    加藤 昌志, 田崎 啓, 大神 信孝, 橋本 和宜

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    Authorship:Principal investigator 

    Grant amount:\45500000 ( Direct Cost: \35000000 、 Indirect Cost:\10500000 )

    代表者等は、開発途上国の飲用井戸水に含まれる多種多様な元素の単独および複合経口曝露による健康被害を報告してきた。上記知見は、経口する井戸水が異なれば、汚染されている元素も異なる可能性を示している。本研究では、まず、開発途上国の飲用水元素汚染の現状に基づき、飲用水に含まれる元素の健康リスクをオーダーメイドで評価できる技術を開発し、浄化すべき元素を特定する。次に、飲用水に含まれる有害元素を過不足なく除去できる浄化技術を開発・実用化することで飲用水に起因する健康被害の緩和をめざす。また、本研究で開発された健康リスク評価技術を用いて、日本人における元素の健康リスクを評価し、健康増進に貢献する。
    元素に汚染された飲用水の健康リスクを正確に評価するためには、「元素曝露状況を解明するフィールドワーク研究」と「環境の影響を受けた個体に対する実験研究」の両方を推進することが必要である。本研究では、元素の経口曝露により誘発される健康被害を予防することを目的とし、1)飲用水元素汚染の現状を把握するとともに、2)疫学研究と実験研究を組み合わせて、元素の健康リスクをオーダーメイドで評価できる技術を開発して浄化すべき元素を特定し、3)オーダーメイドで有害元素を吸着できる浄化技術を開発する 。さらに、途上国における研究成果を用いて、4)日本人における元素の健康影響を評価することで、日本に成果を還元することを目的としている。
    本研究では、バングラデシュの飲用井戸水では、鉄濃度が高いことを示した。さらに、鉄の過剰摂取は、住民の聴力障害を誘発する可能性を報告した(Sci Rep 2019)。また、アフガニスタンの飲用井戸水では、リチウム及びボロンの濃度が高いことを示すとともに、リチウム(Sci Total Environ 2020)及びボロン(Environ Pollut 2020)の潜在的発癌毒性を示した。さらに、iPS細胞を用いて、水銀を例として元素の発生毒性をin vitroで評価できるシステムを開発(Chemosphere 2020)した。こうした研究実績が評価され、2019年度の日本衛生学会・学会賞を受賞し、飲用井戸水の健康リスクに関する研究成果は、学会賞受賞記念総説論文(Environ Health Prev Med 2020)としてまとめられた。
    コロナウイルス感染症のパンデミックにより、開発途上国におけるフィールドワーク研究は、余儀なくペンディング状態になっている。しかし、過去に採取した資料を、より新しい技術で、より詳細に解析することにより、この難局を乗り越える努力をしている。実際に、環境学におけるTop 10% Journalを数編公表しており、本研究は、おおむね順調に研究を進展していると判断できる。
    元素に汚染された飲用水の健康リスクを評価することを目的として、「元素曝露状況を解明するフィールドワーク研究」と「環境の影響を受けた個体に対する実験研究」の両方を推進する。
    1)飲用水元素汚染の現状把握:コロナウイルス感染症の状況を勘案しながら、開発途上国におけるフィールドワーク研究を推進する。フィールドワーク研究が難しい場合は、過去に採取した検体を、より新しい技術で解析することで乗り越える。
    2)元素の健康リスク評価と浄化すべき元素の特定:ICP-MSを用いて、元素取り込みに着目した細胞生物学実験を進める。さらに、LA-ICP-MSを用いて、臓器の元素分布を調べる動物実験を推進する。
    3)浄化技術の開発:日本の基準に対応できる浄化材を開発し、開発途上国への技術移転の準備を進める。
    4)日本人における元素の健康影響を評価:日本人の元素曝露状況を調べるとともに、微量元素曝露が健康に与える影響について、疫学実験で解明する。さらに、ヒトで得られた成果を、動物実験で検証する。

  7. 経済グローバル化により産み出される環境汚染に対する解決スキームの構築

    Grant number:17KT0033  2017.7 - 2023.3

    科学研究費助成事業  基盤研究(B)

    加藤 昌志, 大神 信孝, 矢嶋 伊知朗, 田崎 啓

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    Authorship:Principal investigator 

    Grant amount:\18720000 ( Direct Cost: \14400000 、 Indirect Cost:\4320000 )

    【背景】 我々が日常的に使用している皮革製品は、「クロムなめし」と「その他のもの」に分類される。生産コストが低く、輸入税率も格段に安いので、世界の皮革製品の80%以上は、クロムなめしを用いて作製されている。経済グローバル化に伴い、環境汚染を誘発するクロムなめしの作業工程を途上国が担当する構図が、新たなグローバル・イシューを産み出している。
    【目的】 クロムなめし工場では、皮革製品の製造に大量の水を必要とする。クロムなめし工場から高濃度のクロム等の有害元素を含む大量の廃液が流れ出ると、工場内だけでなく、周辺水域に甚大な環境汚染と健康被害を誘発する可能性がある。本研究は、皮革製品を世界約70ヶ国に輸出しているバングラデシュと、主要輸入国の1つである日本に焦点をあて、1)環境汚染の現状把握→2)汚染物質の健康影響評価→3)解決策の提案・実践からなる研究を推進する。
    【研究実績】 バングラデシュの皮革工場集積地域(ハザリバーグ)は、ブラックスミス研究所の報告において、「世界で最も環境汚染が深刻な10地点」の1つに選別されたこともある重大汚染地域である。本研究は、1)ハザリバーグにおける環境汚染の現状把握(Chemosphere 2018a)を報告するとともに、2)皮革工場労働者(Chemosphere 2019;Environ Res 2020)及び細胞(Chemosphere 2018b)を用いた有害元素の健康影響評価に関する成果を国際科学誌に報告してきた。2021年度は、ハザリバーグにおける有機物による環境汚染を解明するとともに、有機物除去に有効なオリジナルの浄化材を提案した(Chemosphere 2021)。
    本研究は、バングラデシュの皮革工場集積地域における無機物質の汚染に加えて、有機物質の汚染を解明しただけでなく、解決策の1つとなりえる浄化材の開発に成功しているため。
    バングラデシュの皮革工場集積地域(ハザリバーグ)における有害元素汚染に焦点を当て、現状を確認するとともに、解決策となりえる浄化材の開発を推進する。さらに、皮革工場労働者における疫学調査を推進し、皮革工場に起因する有害元素が、ヒトの健康に与える影響を調べる。以上のようにして、1)環境汚染の現状把握→2)汚染物質の健康影響評価→3)解決策の提案・実践からなる研究を推進する。

  8. Clarification of mechanisms and development of preventive methods for health disturbances caused by exposure to low frequency noise

    Grant number:15H01743  2015.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    Kato Masashi

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    Authorship:Principal investigator 

    Grant amount:\45370000 ( Direct Cost: \34900000 、 Indirect Cost:\10470000 )

    In this study, we first developed a device that can produce low frequency sound (low frequency sound stimulator). Then, our experimental study proposed a threshold at which low frequency sound induced health disorders (balance and motor dysfunction), and identified the potential mechanisms and damaged sites (otoliths and otolith membranes) in the vestibule. We also developed a novel system that quickly assesses the health risk of low frequency sound by cultured utricle. Moreover, our epidemiological studies evaluated the health effects of low frequency sound in young adults. Finally, our animal study showed that increased expression level of heat Shock protein 70 expressed in the otolithic membrane can prevent a damage of otolithic membrane and dysfunction of equilibrium and motor caused by low frequency. Thus, we proposed a preventive method for health disturbances caused by exposure to low frequency noise.

  9. Health risk assessment and development of remediation systems for elemental contamination of drinking water in Asian countries

    Grant number:15H02588  2015.4 - 2019.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    Kato Masashi

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    Authorship:Principal investigator 

    Grant amount:\43290000 ( Direct Cost: \33300000 、 Indirect Cost:\9990000 )

    Contamination of toxic elements in well drinking water has caused various element-originating diseases in tens of millions of people in Asian countries. In this study, the comprehensive study was conducted to quickly resolve the international environmental problems related to contamination of toxic elements in well drinking water. First, the present situation of elemental contamination of well drinking water was investigated in the areas including Afghanistan. Then, harmful elements that may induce carcinogenesis and/or disorders of sensory organs (melanosis, hearing loss, etc.) were detected by our multidisciplinary health risk assessment system consisted of experimental and epidemiological analyses. Finally, we developed a new remediation system that can remove harmful elements from well drinking water based on our results of health risk assessment.

  10. Development of a novel molecular target therapy that can suppress melanoma progression

    Grant number:26670525  2014.4 - 2018.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Exploratory Research

    Masashi Kato, YAJIMA Ichiro

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    Authorship:Principal investigator 

    Grant amount:\3640000 ( Direct Cost: \2800000 、 Indirect Cost:\840000 )

    We previous developed RET-transgenic mice (RET-mice), in which development of hyperpigmented skin and benign melanocytic tumors at about 100% and development of melanoma at about 65%. In this study, we first selected molecules after performing microarray analysis using benign tumor and melanoma developed in RET-mouse. We then performed functional analysis for these three molecules. The molecules are involved in the regulation for anchorage- independent growth, invasion and metastasis. Thus, we have not only proposed plural candidate molecules that are available as a biomarker of melanoma but also provided basic data for developing a molecular target therapy that suppress melanoma proliferation, infiltration and metastasis.

  11. プラズマ医療のための気相・表界反応ダイナミクスの計測と体系化

    2012.4 - 2017.3

    科学研究費補助金  新学術領域研究

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    Authorship:Coinvestigator(s) 

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Industrial property rights 2

  1. 聴覚障害又は小脳性運動失調症の予防・治療剤

    大神信孝、加藤昌志

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    Application no:特願2012-259456  Date applied:2012.11

    Country of applicant:Domestic  

  2. 幹細胞を標的とした薬効及び毒性の評価法

    飯田真智子、加藤昌志

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    Application no:特願2012-243119  Date applied:2012.11

    Country of applicant:Domestic  

 

Teaching Experience (On-campus) 9

  1. First Year Seminar B

    2020

  2. Occupational and Environmental Health

    2020

  3. Medical basic seminar

    2020

  4. Experimental Research on Occupational and Environmental Health

    2020

  5. Seminar on Occupational and Environmental Health

    2020

  6. Advanced Occupational and Environmental Health Science

    2020

  7. Occupational and Environmental Health

    2020

  8. Occupational and Environmental Health

    2020

  9. Social Life Science

    2020

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Social Contribution 1

  1. 大学国際保健ボランティア

    Role(s):Investigater

    2006.4

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    Type:Investigation, survey

    開発途上国の環境改善と保健の向上に貢献する。