Updated on 2024/04/16

写真a

 
HASEGAWA Tomokazu
 
Organization
Nagoya University Hospital Anesthesiology Assistant Professor
Title
Assistant Professor
 

Papers 67

  1. Impact of drainage retinotomy on surgical outcomes of retinal detachment: insights from the Japan-Retinal Detachment Registry

    Fukuyama H., Ishikawa H., Gomi F., Yamamoto S., Baba T., Sato E., Kitahashi M., Tatsumi T., Miura G., Niizawa T., Sakamoto T., Yamakiri K., Yamashita T., Otsuka H., Sameshima S., Yoshinaga N., Sonoda S., Hirakata A., Koto T., Inoue M., Hirota K., Itoh Y., Orihara T., Emoto Y., Sano M., Takahashi H., Tokizawa R., Yamashita H., Nishitsuka K., Kaneko Y., Nishi K., Yoshida A., Ono S., Hirokawa H., Sogawa K., Omae T., Ishibazawa A., Kishi S., Akiyama H., Matsu-moto H., Mukai R., Morimoto M., Nakazawa M., Suzuki Y., Kudo T., Adachi K., Ishida S., Noda K., Kase S., Mori S., Ando R., Saito M., Suzuki T., Takahashi K., Nagai Y., Nakauchi T., Yamada H., Kusaka S., Tsujioka D., Tsujikawa A., Suzuma K., Ishibashi T., Sonoda K.H., Ikeda Y., Kohno R., Ishikawa K., Kondo M., Kozawa M., Kitaoka T., Tsuiki E., Ogura Y., Yoshida M., Morita H., Kato A., Hirano Y., Sugitani K., Terasaki H., Iwase T., Ito Y., Ueno S., Kaneko H., Nonobe N., Kominami T., Azuma N., Yokoi T., Shimada H., Nakashizuka H., Hattori T., Shinojima A., Kutagawa Y., Shiraga F., Morizane Y., Kimura S., Ikeda T., Kida T., Sato T., Fukumoto M., Emi K., Nakashima H., Ohji M.

    Scientific Reports   Vol. 14 ( 1 )   2024.12

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    Publisher：Scientific Reports  

    We investigated the impact of drainage retinotomy on the outcome of pars plana vitrectomy for repair of rhegmatogenous retinal detachment (RRD). This study was a retrospective observational multicenter study. All patients were registered with the Japan-Retinal Detachment Registry. We analyzed 1887 eyes with RRD that had undergone vitrectomy and were observed for 6 months between February 2016 and March 2017. We compared the baseline characteristics and postoperative outcomes between eyes with and without drainage retinectomy. We then performed propensity score matching using preoperative findings as covariates to adjust for relevant confounders. Of 3446 eyes, 1887 met the inclusion criteria. Among them, 559 eyes underwent vitrectomy with drainage retinotomy, and 1328 eyes underwent vitrectomy without drainage retinotomy. After propensity score matching, each group comprised 544 eyes. There was no significant difference between the two groups in BCVA at 6 months after vitrectomy (0.181 vs. 0.166, P = 0.23), the primary anatomical success rate (6.3% vs. 4.4%, P = 0.22), or the rate of secondary surgery for ERM within 6 months (1.5% vs. 1.3%, P = 1.0). Drainage retinectomy does not increase the risk of decreased postoperative BCVA, surgical failure, or secondary surgery for ERM within six months outcomes.

    DOI： 10.1038/s41598-024-58453-5

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  2. Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

    Xie O., Morris J.M., Hayes A.J., Towers R.J., Jespersen M.G., Lees J.A., Ben Zakour N.L., Berking O., Baines S.L., Carter G.P., Tonkin-Hill G., Schrieber L., McIntyre L., Lacey J.A., James T.B., Sriprakash K.S., Beatson S.A., Hasegawa T., Giffard P., Steer A.C., Batzloff M.R., Beall B.W., Pinho M.D., Ramirez M., Bessen D.E., Dougan G., Bentley S.D., Walker M.J., Currie B.J., Tong S.Y.C., McMillan D.J., Davies M.R.

    Nature Communications   Vol. 15 ( 1 )   2024.12

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    Publisher：Nature Communications  

    Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic genomic analyses of 501 disseminated SDSE strains, we demonstrate extensive overlap between the genomes of SDSE and S. pyogenes. More than 75% of core genes are shared between the two species with one third demonstrating evidence of cross-species recombination. Twenty-five percent of mobile genetic element (MGE) clusters and 16 of 55 SDSE MGE insertion regions were shared across species. Assessing potential cross-protection from leading S. pyogenes vaccine candidates on SDSE, 12/34 preclinical vaccine antigen genes were shown to be present in >99% of isolates of both species. Relevant to possible vaccine evasion, six vaccine candidate genes demonstrated evidence of inter-species recombination. These findings demonstrate previously unappreciated levels of genomic overlap between these closely related pathogens with implications for streptococcal pathobiology, disease surveillance and prevention.

    DOI： 10.1038/s41467-024-46530-2

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  3. Impact of malnutrition on mortality and neurological recovery of older patients with spinal cord injury

    Tamai K., Terai H., Nakamura H., Yokogawa N., Sasagawa T., Nakashima H., Segi N., Ito S., Funayama T., Eto F., Yamaji A., Watanabe K., Yamane J., Takeda K., Furuya T., Yunde A., Nakajima H., Yamada T., Hasegawa T., Terashima Y., Hirota R., Suzuki H., Imajo Y., Ikegami S., Uehara M., Tonomura H., Sakata M., Hashimoto K., Onoda Y., Kawaguchi K., Haruta Y., Suzuki N., Kato K., Uei H., Sawada H., Nakanishi K., Misaki K., Kuroda A., Inoue G., Kakutani K., Kakiuchi Y., Kiyasu K., Tominaga H., Tokumoto H., Iizuka Y., Takasawa E., Akeda K., Takegami N., Funao H., Oshima Y., Kaito T., Sakai D., Yoshii T., Ohba T., Otsuki B., Seki S., Miyazaki M., Ishihara M., Okada S., Imagama S., Kato S.

    Scientific Reports   Vol. 14 ( 1 ) page： 5853   2024.12

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    Language：English   Publisher：Scientific Reports  

    This retrospective cohort study established malnutrition’s impact on mortality and neurological recovery of older patients with cervical spinal cord injury (SCI). It included patients aged ≥ 65 years with traumatic cervical SCI treated conservatively or surgically. The Geriatric Nutritional Risk Index was calculated to assess nutritional-related risk. Overall, 789 patients (mean follow-up: 20.1 months) were examined and 47 had major nutritional-related risks on admission. One-year mortality rate, median survival time, neurological recovery, and activities of daily living (ADL) at 1 year post-injury were compared between patients with major nutrition-related risk and matched controls selected using 1:2 propensity score matching to adjust for age, pre-traumatic neurological impairment, and activity. In the Kaplan–Meier analysis, the median survival times were 44.9 and 76.5 months for patients with major nutrition-related risk and matched controls, respectively (p = 0.015). Matched controls had more individuals with a neurological improvement of American Spinal Injury Association Impairment Scale ≥ 1 grade (p = 0.039) and independence in ADL at 1 year post-injury than patients with major nutrition-related risk (p < 0.05). In conclusion, 6% of older patients with cervical SCI had major nutrition-related risks; they showed a significantly higher 1 year mortality rate, shorter survival time, poorer neurological improvement, and lower ADL at 1 year post-injury than matched controls.

    DOI： 10.1038/s41598-024-56527-y

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  4. Efficacy of perioperative oral care management in the prevention of surgical complications in 503 patients after pancreaticoduodenectomy for resectable malignant tumor: A multicenter retrospective analysis using propensity score matching

    Yamguchi T., Mori K., Kojima Y., Hasegawa T., Hirota J., Akashi M., Soutome S., Yoshimatsu M., Nobuhara H., Matsugu Y., Kato S., Shibuya Y., Kurita H., Yamada S.i., Nakahara H.

    Surgery (United States)   Vol. 175 ( 4 ) page： 1128 - 1133   2024.4

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    Publisher：Surgery (United States)  

    Background: Pancreaticoduodenectomy has been associated with a high mortality rate and significant postoperative morbidity. Recently, perioperative oral care management has been reported to be effective in preventing postoperative pneumonia and surgical site infection. In this study, we examined the effect of perioperative oral care management in reducing complications after pancreaticoduodenectomy, including surgical site infection. Methods: This retrospective multicenter study included 503 patients who underwent pancreaticoduodenectomy at 8 facilities between January 2014 and December 2016. Among these, 144 received perioperative oral management by dentists and dental hygienists (oral management group), whereas the remaining 359 did not (control group). The oral care management program included oral health instructions, removal of dental calculus, professional mechanical tooth cleaning, removal of tongue coating, denture cleaning, instructions for gargling, and tooth extraction. The participants were matched using propensity scores to reduce background bias. Various factors were examined for correlation with the development of complications. Results: The incidence of organ/space surgical site infection was significantly lower in the oral management group than in the control group (8.0% vs 19.6%, P = .005). Multivariable logistic regression analysis revealed that hypertension and lack of perioperative oral management were independent risk factors for organ/space surgical site infection. Lack of perioperative oral management had an odds ratio of 2.847 (95% confidence interval 1.335–6.071, P = .007). Conclusion: Perioperative oral care management reduces the occurrence of surgical site infections after pancreaticoduodenectomy and should be recommended as a strategy to prevent infections in addition to antibiotic use.

    DOI： 10.1016/j.surg.2023.11.008

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  5. Influence of the timing of surgery for cervical spinal cord injury without bone injury in the elderly: A retrospective multicenter study

    Nori S., Watanabe K., Takeda K., Yamane J., Kono H., Yokogawa N., Sasagawa T., Ando K., Nakashima H., Segi N., Funayama T., Eto F., Yamaji A., Furuya T., Yunde A., Nakajima H., Yamada T., Hasegawa T., Terashima Y., Hirota R., Suzuki H., Imajo Y., Ikegami S., Uehara M., Tonomura H., Sakata M., Hashimoto K., Onoda Y., Kawaguchi K., Haruta Y., Uei H., Sawada H., Nakanishi K., Misaki K., Terai H., Tamai K., Shirasawa E., Inoue G., Kiyasu K., Iizuka Y., Takasawa E., Funao H., Kaito T., Yoshii T., Ishihara M., Okada S., Imagama S., Kato S.

    Journal of Orthopaedic Science   Vol. 29 ( 2 ) page： 480 - 485   2024.3

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    Language：English   Publisher：Journal of Orthopaedic Science  

    Background: Although previous studies have demonstrated the advantages of early surgery for traumatic spinal cord injury (SCI), the appropriate surgical timing for cervical SCIs (CSCIs) without bone injury remains controversial. Here, we investigated the influence of relatively early surgery within 48 h of injury on the neurological recovery of elderly patients with CSCI and no bone injury. Methods: In this retrospective multicenter study, we reviewed data from 159 consecutive patients aged ≥65 years with CSCI without bone injury who underwent surgery in participating centers between 2010 and 2020. Patients were followed up for at least 6 months following CSCI. We divided patients into relatively early (≤48 h after CSCI, n = 24) and late surgery (>48 h after CSCI, n = 135) groups, and baseline characteristics and neurological outcomes were compared between them. Multivariate analysis was performed to identify factors associated with neurological recovery. Results: The relatively early surgery group demonstrated a lower prevalence of cardiac disease, poorer baseline American Spinal Injury Association (ASIA) impairment scale grade, and lower baseline ASIA motor score (AMS) than those of the late surgery group (P < 0.030, P < 0.001, and P < 0.001, respectively). Although the AMS was lower in the relatively early surgery group at 6 months following injury (P = 0.001), greater improvement in this score from baseline to 6-months post injury was observed (P = 0.010). Multiple linear regression analysis revealed that relatively early surgery did not affect postoperative improvement in AMS, rather, lower baseline AMS was associated with better AMS improvement (P < 0.001). Delirium (P = 0.006), pneumonia (P = 0.030), and diabetes mellitus (P = 0.039) negatively influenced postoperative improvement. Conclusions: Although further validation by future studies is required, relatively early surgery did not show a positive influence on neurological recovery after CSCI without bone injury in the elderly.

    DOI： 10.1016/j.jos.2023.01.004

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  6. Neurological recovery rate and predictive factors of incomplete AIS grade C spinal cord injury in the older aged population

    Tamai, K; Terai, H; Nakamura, H; Yokogawa, N; Sasagawa, T; Nakashima, H; Segi, N; Ito, S; Funayama, T; Eto, F; Yamaji, A; Watanabe, K; Yamane, J; Takeda, K; Furuya, T; Yunde, A; Nakajima, H; Yamada, T; Hasegawa, T; Terashima, Y; Hirota, R; Suzuki, H; Imajo, Y; Ikegami, S; Uehara, M; Tonomura, H; Sakata, M; Hashimoto, K; Onoda, Y; Kawaguchi, K; Haruta, Y; Suzuki, N; Kato, K; Uei, H; Sawada, H; Nakanishi, K; Misaki, K; Kuroda, A; Inoue, G; Kakutani, K; Kakiuchi, Y; Kiyasu, K; Tominaga, H; Tokumoto, H; Iizuka, Y; Takasawa, E; Akeda, K; Takegami, N; Funao, H; Oshima, Y; Kaito, T; Sakai, D; Yoshii, T; Ohba, T; Otsuki, B; Seki, S; Miyazaki, M; Ishihara, M; Okada, S; Imagama, S; Kato, S

    SPINAL CORD     2024.2

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    Language：English   Publisher：Spinal Cord  

    Study design: Retrospective cohort study. Objectives: To define the prognosis and predictive factors for neurological improvement in older patients with incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale grade C (AIS-C). Settings: Multi-institutions in Japan. Methods: We included patients aged ≥65 years with traumatic SCI of AIS-C who were treated conservatively or surgically with >3 follow-up months. To identify factors related to neurological improvement, patients were divided into three groups according to their neurological status at the final follow-up, with univariate among-group comparisons of demographics, radiographic, and therapeutic factors. Significant variables were included in the multivariate logistic regression analysis. Results: Overall, 296 older patients with SCI of AIS-C on admission were identified (average age: 75.2 years, average follow-up: 18.7 months). Among them, 190 (64.2%) patients improved to AIS-D and 21 (7.1%) patients improved to AIS-E at final follow-up. There were significant among-group differences in age (p = 0.026), body mass index (p = 0.007), status of pre-traumatic activities of daily living (ADL) (p = 0.037), and serum albumin concentrations (p = 0.011). Logistic regression analysis showed no significant differences in variables in the stratified group of patients who improved to AIS-D. Meanwhile, serum albumin was a significant variable in patients who improved to AIS-E (p = 0.026; OR: 6.20, pre-traumatic ADL was omitted due to data skewness). Conclusions: Most older patients with incomplete AIS-C SCI demonstrated at least 1 grade of neurological improvement. However, <10% of patients achieved complete recovery. Key predictors of complete recovery were high serum albumin levels on admission and independent pre-traumatic ADL. Sponsorship: No funding was received for this study.

    DOI： 10.1038/s41393-024-00963-0

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  7. Filamentary Network and Magnetic Field Structures Revealed with BISTRO in the High-mass Star-forming Region NGC 2264: Global Properties and Local Magnetogravitational Configurations

    Wang, JW; Koch, PM; Clarke, SD; Fuller, G; Peretto, N; Tang, YW; Yen, HW; Lai, SP; Ohashi, N; Arzoumanian, D; Johnstone, D; Furuya, R; Inutsuka, SI; Lee, CW; Ward-Thompson, D; Le Gouellec, VJM; Liu, HL; Fanciullo, L; Hwang, J; Pattle, K; Poidevin, F; Tahani, M; Onaka, T; Rawlings, MG; Chung, EJ; Liu, JH; Lyo, AR; Priestley, F; Hoang, T; Tamura, M; Berry, D; Bastien, P; Ching, TC; Coudé, S; Kwon, W; Chen, MK; Eswaraiah, C; Soam, A; Hasegawa, T; Qiu, KP; Bourke, TL; Byun, D; Chen, ZW; Chen, HRV; Chen, WP; Cho, JY; Choi, M; Choi, Y; Choi, Y; Chrysostomou, A; Dai, SP; Di Francesco, J; Diep, PN; Doi, Y; Duan, Y; Duan, HY; Eden, D; Fiege, J; Fissel, LM; Franzmann, E; Friberg, P; Friesen, R; Gledhill, T; Graves, S; Greaves, J; Griffin, M; Gu, QL; Han, IL; Hayashi, S; Houde, M; Inoue, T; Iwasaki, K; Jeong, I; Könyves, V; Kang, JH; Kang, MJ; Karoly, J; Kataoka, A; Kawabata, K; Khan, Z; Kim, MR; Kim, KT; Kim, KH; Kim, S; Kim, J; Kim, H; Kim, G; Kirchschlager, F; Kirk, J; Kobayashi, MIN; Kusune, T; Kwon, J; Lacaille, K; Law, CY; Lee, SS; Lee, HYS; Lee, JE; Lee, CF; Li, DL; Li, HB; Li, GX; Li, D; Lin, SJ; Liu, T; Liu, SY; Lu, X; Mairs, S; Matsumura, M; Matthews, B; Moriarty-Schieven, G; Nagata, T; Nakamura, F; Nakanishi, H; Ngoc, NB; Park, G; Parsons, H; Pyo, TS; Qian, L; Rao, RMS; Rawlings, J; Retter, B; Richer, J; Rigby, A; Sadavoy, S; Saito, H; Savini, G; Seta, M; Sharma, E; Shimajiri, Y; Shinnaga, H; Tang, XD; Thuong, HD; Tomisaka, K; Tram, L; Tsukamoto, Y; Viti, S; Wang, HC; Whitworth, A; Wu, JT; Xie, JJ; Yang, MZ; Yoo, H; Yuan, JH; Yun, HS; Zenko, T; Zhang, CP; Zhang, YP; Zhang, GY; Zhou, JJ; Zhu, L; de Looze, I; André, P; Dowell, CD; Eyres, S; Falle, S; Robitaille, JF; van Loo, S

    ASTROPHYSICAL JOURNAL   Vol. 962 ( 2 )   2024.2

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    Publisher：Astrophysical Journal  

    We report 850 μm continuum polarization observations toward the filamentary high-mass star-forming region NGC 2264, taken as part of the B-fields In STar forming Regions Observations large program on the James Clerk Maxwell Telescope. These data reveal a well-structured nonuniform magnetic field in the NGC 2264C and 2264D regions with a prevailing orientation around 30° from north to east. Field strength estimates and a virial analysis of the major clumps indicate that NGC 2264C is globally dominated by gravity, while in 2264D, magnetic, gravitational, and kinetic energies are roughly balanced. We present an analysis scheme that utilizes the locally resolved magnetic field structures, together with the locally measured gravitational vector field and the extracted filamentary network. From this, we infer statistical trends showing that this network consists of two main groups of filaments oriented approximately perpendicular to one another. Additionally, gravity shows one dominating converging direction that is roughly perpendicular to one of the filament orientations, which is suggestive of mass accretion along this direction. Beyond these statistical trends, we identify two types of filaments. The type I filament is perpendicular to the magnetic field with local gravity transitioning from parallel to perpendicular to the magnetic field from the outside to the filament ridge. The type II filament is parallel to the magnetic field and local gravity. We interpret these two types of filaments as originating from the competition between radial collapsing, driven by filament self-gravity, and longitudinal collapsing, driven by the region's global gravity.

    DOI： 10.3847/1538-4357/ad165b

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  8. Elements of End-of-Life Discussions Associated With Patients’ Reported Outcomes and Actual End-of-Life Care in Patients With Pretreated Lung Cancer

    Hasegawa T., Okuyama T., Uemura T., Matsuda Y., Otani H., Shimizu J., Horio Y., Watanabe N., Yamaguchi T., Fukuda S., Oguri T., Maeno K., Taniguchi Y., Nosaki K., Fukumitsu K., Akechi T.

    Oncologist   Vol. 29 ( 2 ) page： E282 - E289   2024.2

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    Publisher：Oncologist  

    Background: End-of-life discussions for patients with advanced cancer are internationally recommended to ensure consistency of end-of-life care with patients’ values. This study examined the elements of end-of-life discussions associated with end-of-life care. Materials and Methods: We performed a prospective observational study among consecutive patients with pretreated non-small cell lung cancer after the failure of first-line chemotherapy. We asked oncologists whether they had ever discussed “prognosis,” “do not attempt resuscitation,” “hospice,” and “preferred place of death” with a patient at baseline. The quality of life (QOL) and depressive symptoms of patients were assessed using validated questionnaires at baseline and 3 months later. The end-of-life care that patients received was investigated using medical records. Oncologists’ compassion and caregivers’ preferences for hospice care were also assessed using questionnaires. Multiple regression analyses were conducted to examine the association between elements of end-of-life discussions and patient-reported outcomes as well as actual end-of-life care. Results: We obtained 200 valid responses at baseline, 147 valid responses 3 months later, and 145 data points for medical care at the end-of-life stage. No element of the end-of-life discussion between the patient and their oncologist was significantly associated with patients’ reported outcomes or actual end-of-life care. In addition, oncologists’ compassion was significantly associated with improvement in both comprehensive QOL and depressive symptoms, and caregivers’ preferences for hospice care and high educational level were significantly associated with hospice death. Conclusion: Oncologist-patient alliances and caregivers’ involvement in end-of-life discussions may be influential in achieving optimal end-of-life care.

    DOI： 10.1093/oncolo/oyad245

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  9. Cosmogenic background simulations for neutrinoless double beta decay with the DARWIN observatory at various underground sites

    Adrover, M; Althueser, L; Andrieu, B; Angelino, E; Angevaare, JR; Antunovic, B; Aprile, E; Babicz, M; Bajpai, D; Barberio, E; Baudis, L; Bazyk, M; Bell, N; Bellagamba, L; Biondi, R; Biondi, Y; Bismark, A; Boehm, C; Breskin, A; Brookes, EJ; Brown, A; Bruno, G; Budnik, R; Capelli, C; Cardoso, JMR; Chauvin, A; Chavez, APC; Colijn, AP; Conrad, J; Cuenca-García, JJ; D'Andrea, V; Decowski, MP; Deisting, A; Di Gangi, P; Diglio, S; Doerenkamp, M; Drexlin, G; Eitel, K; Elykov, A; Engel, R; Farrell, S; Ferella, AD; Ferrari, C; Fischer, H; Flierman, M; Fulgione, W; Gaemers, P; Gaior, R; Galloway, M; Garroum, N; Ghosh, S; Girard, F; Glade-Beucke, R; Glück, F; Grandi, L; Grigat, J; Grössle, R; Guan, H; Guida, M; Hammann, R; Hannen, V; Hansmann-Menzemer, S; Hargittai, N; Hasegawa, T; Hils, C; Higuera, A; Hiraoka, K; Hoetzsch, L; Iacovacci, M; Itow, Y; Jakob, J; Jörg, F; Kara, M; Kavrigin, P; Kazama, S; Keller, M; Kilminster, B; Kleifges, M; Kobayashi, M; Kopec, A; von Krosigk, B; Kuger, F; Landsman, H; Lang, RF; Li, I; Li, S; Liang, S; Lindemann, S; Lindner, M; Lombardi, F; Loizeau, J; Luce, T; Ma, Y; Macolino, C; Mahlstedt, J; Mancuso, A; Undagoitia, TM; Lopes, JAM; Marignetti, F; Martens, K; Masbou, J; Mastroianni, S; Milutinovic, S; Miuchi, K; Miyata, R; Molinario, A; Monteiro, CMB; Morå, K; Morteau, E; Mosbacher, Y; Müller, J; Murra, M; Newstead, JL; Ni, K; Oberlack, UG; Ostrovskiy, I; Paetsch, B; Pandurovic, M; Pellegrini, Q; Peres, R; Pienaar, J; Pierre, M; Piotter, M; Plante, G; Pollmann, TR; Principe, L; Qi, J; Qin, J; Silva, MR; García, DR; Razeto, A; Sakamoto, S; Sanchez, L; Sanchez-Lucas, P; dos Santos, JMF; Sartorelli, G; Scaffidi, A; Schulte, P; Schultz-Coulon, HC; Eissing, HS; Schumann, M; Lavina, LS; Selvi, M; Semeria, F; Shagin, P; Sharma, S; Shen, W; Silva, M; Simgen, H; Singh, R; Solmaz, M; Stanley, O; Steidl, M; Tan, PL; Terliuk, A; Thers, D; Thuemmler, T; Toennies, F; Toschi, F; Trinchero, G; Trotta, R; Tunnell, C; Urquijo, P; Valerius, K; Vecchi, S; Vetter, S; Volta, G; Vorkapic, D; Wang, W; Weerman, KM; Weinheimer, C; Weiss, M; Wenz, D; Wittweg, C; Wolf, J; Wolf, T; Wu, VHS; Wurm, M; Xing, Y; Yamashita, M; Ye, J; Zavattini, G; Zuber, K

    EUROPEAN PHYSICAL JOURNAL C   Vol. 84 ( 1 )   2024.1

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    Publisher：European Physical Journal C  

    Xenon dual-phase time projections chambers (TPCs) have proven to be a successful technology in studying physical phenomena that require low-background conditions. With 40t of liquid xenon (LXe) in the TPC baseline design, DARWIN will have a high sensitivity for the detection of particle dark matter, neutrinoless double beta decay (0 ν β β), and axion-like particles (ALPs). Although cosmic muons are a source of background that cannot be entirely eliminated, they may be greatly diminished by placing the detector deep underground. In this study, we used Monte Carlo simulations to model the cosmogenic background expected for the DARWIN observatory at four underground laboratories: Laboratori Nazionali del Gran Sasso (LNGS), Sanford Underground Research Facility (SURF), Laboratoire Souterrain de Modane (LSM) and SNOLAB. We present here the results of simulations performed to determine the production rate of 137 Xe, the most crucial isotope in the search for 0 ν β β of 136 Xe. Additionally, we explore the contribution that other muon-induced spallation products, such as other unstable xenon isotopes and tritium, may have on the cosmogenic background.

    DOI： 10.1140/epjc/s10052-023-12298-w

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  10. Early Versus Delayed Surgery for Elderly Traumatic Cervical Spinal Injury: A Nationwide Multicenter Study in Japan

    Segi, N; Nakashima, H; Ito, S; Yokogawa, N; Sasagawa, T; Watanabe, K; Nori, S; Funayama, T; Eto, F; Nakajima, H; Terashima, Y; Hirota, R; Hashimoto, K; Onoda, Y; Furuya, T; Yunde, A; Ikegami, S; Uehara, M; Suzuki, H; Imajo, Y; Uei, H; Sawada, H; Kawaguchi, K; Nakanishi, K; Suzuki, N; Oshima, Y; Hasegawa, T; Iizuka, Y; Tonomura, H; Terai, H; Akeda, K; Seki, S; Ishihara, M; Inoue, G; Funao, H; Yoshii, T; Kaito, T; Kiyasu, K; Tominaga, H; Kakutani, K; Sakai, D; Ohba, T; Otsuki, B; Miyazaki, M; Murotani, K; Okada, S; Imagama, S; Kato, S

    GLOBAL SPINE JOURNAL     page： 21925682241227430   2024.1

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    Language：English   Publisher：Global Spine Journal  

    Study Design: Retrospective multicenter study. Objectives: The effectiveness of early surgery for cervical spinal injury (CSI) has been demonstrated. However, whether early surgery improves outcomes in the elderly remains unclear. This study investigated whether early surgery for CSI in elderly affects complication rates and neurological outcomes. Methods: This retrospective multicenter study included 462 patients. We included patients with traumatic acute cervical spinal cord injury aged ≥65 years who were treated surgically, whereas patients with American Spinal Injury Association (ASIA) Impairment Scale E, those with unknown operative procedures, and those waiting for surgery for >1 month were excluded. The minimum follow-up period was 6 months. Sixty-five patients (early group, 14.1%) underwent surgical treatment within 24 hours, whereas the remaining 397 patients (85.9%) underwent surgery on a standby basis (delayed group). The propensity score-matched cohorts of 63 cases were compared. Results: Patients in the early group were significantly younger, had significantly more subaxial dislocations (and fractures), tetraplegia, significantly lower ASIA motor scores, and ambulatory abilities 6 months after injury. However, no significant differences in the rate of complications, ambulatory abilities, or ASIA Impairment Scale scores 6 months after injury were observed between the matched cohorts. At 6 months after injury, 61% of the patients in the early group (25% unsupported and 36% supported) and 53% of the patients in the delayed group (34% unsupported and 19% supported) were ambulatory. Conclusions: Early surgery is possible for CSI in elderly patients as the matched cohort reveals no significant difference in complication rates and neurological or ambulatory recovery between the early and delayed surgery groups.

    DOI： 10.1177/21925682241227430

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  11. Measurement of the neutrino-oxygen neutral-current quasielastic cross section using atmospheric neutrinos in the SK-Gd experiment

    Sakai, S; Abe, K; Bronner, C; Hayato, Y; Hiraide, K; Hosokawa, K; Ieki, K; Ikeda, M; Kameda, J; Kanemura, Y; Kaneshima, R; Kashiwagi, Y; Kataoka, Y; Miki, S; Mine, S; Miura, M; Moriyama, S; Nakano, Y; Nakahata, M; Nakayama, S; Noguchi, Y; Sato, K; Sekiya, H; Shiba, H; Shimizu, K; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Tanaka, H; Yano, T; Han, S; Kajita, T; Okumura, K; Tashiro, T; Tomiya, T; Wang, X; Yoshida, S; Fernandez, P; Labarga, L; Ospina, N; Zaldivar, B; Pointon, BW; Kearns, E; Raaf, JL; Wan, L; Wester, T; Bian, J; Griskevich, NJ; Locke, S; Smy, MB; Sobel, HW; Takhistov, V; Yankelevich, A; Hill, J; Jang, MC; Lee, SH; Moon, DH; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Beauchêne, A; Drapier, O; Giampaolo, A; Mueller, TA; Santos, AD; Paganini, P; Quilain, B; Nakamura, T; Jang, JS; Machado, LN; Learned, JG; Choi, K; Iovine, N; Cao, S; Anthony, LHV; Martin, D; Prouse, NW; Scott, M; Sztuc, AA; Uchida, Y; Berardi, V; Calabria, NF; Catanesi, MG; Radicioni, E; Langella, A; De Rosa, G; Collazuol, G; Iacob, F; Mattiazzi, M; Ludovici, L; Gonin, M; Pronost, G; Fujisawa, C; Maekawa, Y; Nishimura, Y; Okazaki, R; Akutsu, R; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Jakkapu, M; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Bhuiyan, N; Burton, GT; Di Lodovico, F; Gao, J; Goldsack, A; Katori, T; Migenda, J; Ramsden, RM; Xie, Z; Zsoldos, S; Suzuki, AT; Takagi, Y; Zhong, H; Takeuchi, Y; Feng, J; Feng, L; Hu, JR; Hu, Z; Kawaue, M; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Jenkins, SJ; McCauley, N; Mehta, P; Tarant, A; Fukuda, Y; Itow, Y; Menjo, H; Ninomiya, K; Yoshioka, Y; Lagoda, J; Lakshmi, SM; Mandal, M; Mijakowski, P; Prabhu, YS; Zalipska, J; Jia, M; Jiang, J; Jung, CK; Shi, W; Wilking, MJ; Yanagisawa, C; Harada, M; Hino, Y; Ishino, H; Koshio, Y; Nakanishi, F; Tada, T; Tano, T; Ishizuka, T; Barr, G; Barrow, D; Cook, L; Samani, S; Wark, D; Holin, A; Nova, F; Jung, S; Yang, BS; Yang, JY; Yoo, J; Fannon, JEP; Kneale, L; Malek, M; McElwee, JM; Thiesse, MD; Thompson, LF; Wilson, ST; Okazawa, H; Kim, SB; Kwon, E; Seo, JW; Yu, I; Ichikawa, AK; Nakamura, KD; Tairafune, S; Nishijima, K; Eguchi, A; Nakagiri, K; Nakajima, Y; Shima, S; Taniuchi, N; Watanabe, E; Yokoyama, M; de Perio, P; Fujita, S; Martens, K; Tsui, KM; Vagins, MR; Xia, J; Izumiyama, S; Kuze, M; Matsumoto, R; Ishitsuka, M; Ito, H; Ommura, Y; Shigeta, N; Shinoki, M; Yamauchi, K; Yoshida, T; Gaur, R; Gousy-Leblanc, V; Hartz, M; Konaka, A; Li, X; Chen, S; Xu, BD; Zhang, B; Posiadala-Zezula, M; Boyd, SB; Edwards, R; Hadley, D; Nicholson, M; O'Flaherty, M; Richards, B; Ali, A; Jamieson, B; Amanai, S; Marti, L; Minamino, A; Suzuki, S

    PHYSICAL REVIEW D   Vol. 109 ( 1 )   2024.1

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    We report the first measurement of the atmospheric neutrino-oxygen neutral-current quasielastic (NCQE) cross section in the gadolinium-loaded Super-Kamiokande (SK) water Cherenkov detector. In June 2020, SK began a new experimental phase, named SK-Gd, by loading 0.011% by mass of gadolinium into the ultrapure water of the SK detector. The introduction of gadolinium to ultrapure water has the effect of improving the neutron-tagging efficiency. Using a 552.2 day dataset from August 2020 to June 2022, we measure the NCQE cross section to be 0.74±0.22(stat)-0.15+0.85(syst)×10-38 cm2/oxygen in the energy range from 160 MeV to 10 GeV, which is consistent with the atmospheric neutrino-flux-averaged theoretical NCQE cross section and the measurement in the SK pure-water phase within the uncertainties. Furthermore, we compare the models of the nucleon-nucleus interactions in water and find that the binary cascade model and the Liège intranuclear cascade model provide a somewhat better fit to the observed data than the Bertini cascade model. Since the atmospheric neutrino-oxygen NCQE reactions are one of the main backgrounds in the search for diffuse supernova neutrino background (DSNB), these new results will contribute to future studies - and the potential discovery - of the DSNB in SK.

    DOI： 10.1103/PhysRevD.109.L011101

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  12. Efficacy of intraoperative irrigation with artificial cerebrospinal fluid in chronic subdural hematoma surgery: study protocol for a multicenter randomized controlled trial

    Nagashima, Y; Araki, Y; Nishida, K; Kuramitsu, S; Wakabayashi, K; Shimato, S; Kinkori, T; Nishizawa, T; Kano, T; Hasegawa, T; Noda, A; Maeda, K; Yamamoto, Y; Suzuki, O; Koketsu, N; Okada, T; Iwasaki, M; Nakabayashi, K; Fujitani, S; Maki, H; Kuwatsuka, Y; Nishihori, M; Tanei, T; Nishikawa, T; Nishimura, Y; Saito, R

    TRIALS   Vol. 25 ( 1 ) page： 6   2024.1

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    Background: The surgical techniques for treatment of chronic subdural hematoma (CSDH), a common neurosurgical condition, have been discussed in a lot of clinical literature. However, the recurrence proportion after CSDH surgery remains high, ranging from 10 to 20%. The standard surgical procedure for CSDH involves a craniostomy to evacuate the hematoma, but irrigating the hematoma cavity during the procedure is debatable. The authors hypothesized that the choice of irrigation fluid might be a key factor affecting the outcomes of surgery. This multicenter randomized controlled trial aims to investigate whether intraoperative irrigation using artificial cerebrospinal fluid (ACF) followed by the placement of a subdural drain would yield superior results compared to the placement of a subdural drain alone for CSDH. Methods: The study will be conducted across 19 neurosurgical departments in Japan. The 1186 eligible patients will be randomly allocated to two groups: irrigation using ACF or not. In either group, a subdural drain is to be placed for at least 12 h postoperatively. Similar to what was done in previous studies, we set the proportion of patients that meet the criteria for ipsilateral reoperation at 7% in the irrigation group and 12% in the non-irrigation group. The primary endpoint is the proportion of patients who meet the criteria for ipsilateral reoperation within 6 months of surgery (clinical worsening of symptoms and increased hematoma on imaging compared with the postoperative state). The secondary endpoints are the proportion of reoperations within 6 months, the proportion being stratified by preoperative hematoma architecture by computed tomography (CT) scan, neurological symptoms, patient condition, mortality at 6 months, complications associated with surgery, length of hospital stay from surgery to discharge, and time of the surgical procedure. Discussion: We present the study protocol for a multicenter randomized controlled trial to investigate our hypothesis that intraoperative irrigation with ACF reduces the recurrence proportion after the removal of chronic subdural hematomas compared with no irrigation. Trial registration: ClinicalTrials.gov jRCT1041220124. Registered on January 13, 2023.

    DOI： 10.1186/s13063-023-07889-7

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  13. Prognostic Factors for Respiratory Dysfunction for Cervical Spinal Cord Injury and/or Cervical Fractures in Elderly Patients: A Multicenter Survey

    Hirota, R; Terashima, Y; Ohnishi, H; Yamashita, T; Yokogawa, N; Sasagawa, T; Ando, K; Nakashima, H; Segi, N; Funayama, T; Eto, F; Yamaji, A; Watanabe, K; Yamane, J; Takeda, K; Furuya, T; Yunde, A; Nakajima, H; Yamada, T; Hasegawa, T; Suzuki, H; Imajo, Y; Ikegami, S; Uehara, M; Tonomura, H; Sakata, M; Hashimoto, K; Onoda, Y; Kawaguchi, K; Haruta, Y; Suzuki, N; Kato, K; Uei, H; Sawada, H; Nakanishi, K; Misaki, K; Terai, H; Tamai, K; Shirasawa, E; Inoue, G; Kakutani, K; Kakiuchi, Y; Kiyasu, K; Tominaga, H; Tokumoto, H; Iizuka, Y; Takasawa, E; Akeda, K; Takegami, N; Funao, H; Oshima, Y; Kaito, T; Sakai, D; Yoshii, T; Ohba, T; Otsuki, B; Seki, S; Miyazaki, M; Ishihara, M; Okada, S; Imagama, S; Kato, S

    GLOBAL SPINE JOURNAL   Vol. 14 ( 1 ) page： 101 - 112   2024.1

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    Study design: Retrospective Cohort Study Objective: The purpose of this study was to investigate the prognosis of respiratory function in elderly patients with cervical spinal cord injury (SCI) and to identify predictive factors. Methods: We included 1353 cases of elderly cervical SCI patients collected from 78 institutions in Japan. Patients who required early tracheostomy and ventilator management and those who developed respiratory complications were defined as the respiratory disability group. Patients’ background characteristics, injury mechanism, injury form, neurological disability, complications, and treatment methods were compared between the disability and non-disability groups. Multiple logistic regression analysis was used to examine the independent factors. Patients who required respiratory management for 6 months or longer after injury and those who died of respiratory complications were classified into the severe disability group and were compared with minor cases who were weaned off the respirator. Results: A total of 104 patients (7.8%) had impaired respiratory function. Comparisons between the disabled and non-disabled groups and between the severe and mild injury groups yielded distinct trends. In multiple logistic regression analysis, age, blood glucose level, presence of ossification of posterior longitudinal ligament (OPLL), anterior vertebral hematoma, and critical paralysis were selected as independent risk factors. Conclusion: Age, OPLL, severe paralysis, anterior vertebral hematoma, hypoalbuminemia, and blood glucose level at the time of injury were independent factors for respiratory failure. Hyperglycemia may have a negative effect on respiratory function in this condition.

    DOI： 10.1177/21925682221095470

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  14. Residual kidney function modifies the effect of cinacalcet on serum phosphorus levels among peritoneal dialysis patients

    Murashima M., Fujii N., Goto S., Hasegawa T., Abe M., Hanafusa N., Fukagawa M., Hamano T.

    Journal of Nephrology     2024

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    DOI： 10.1007/s40620-023-01863-x

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  15. Clinical Characteristics of Cryopyrin-Associated Periodic Syndrome and Long-Term Real-World Efficacy and Tolerability of Canakinumab in Japan: Results of a Nationwide Survey

    Miyamoto T., Izawa K., Masui S., Yamazaki A., Yamasaki Y., Matsubayashi T., Shiraki M., Ohnishi H., Yasumura J., Kawabe T., Miyamae T., Matsubara T., Arakawa N., Ishige T., Takizawa T., Shimbo A., Shimizu M., Kimura N., Maeda Y., Maruyama Y., Shigemura T., Furuta J., Sato S., Tanaka H., Izumikawa M., Yamamura M., Hasegawa T., Kaneko H., Nakagishi Y., Nakano N., Iida Y., Nakamura T., Wakiguchi H., Hoshina T., Kawai T., Murakami K., Akizuki S., Morinobu A., Ohmura K., Eguchi K., Sonoda M., Ishimura M., Furuno K., Kashiwado M., Mori M., Kawahata K., Hayama K., Shimoyama K., Sasaki N., Ito T., Umebayashi H., Omori T., Nakamichi S., Dohmoto T., Hasegawa Y., Kawashima H., Watanabe S., Taguchi Y., Nakaseko H., Iwata N., Kohno H., Ando T., Ito Y., Kataoka Y., Saeki T., Kaneko U., Murase A., Hattori S., Nozawa T., Nishimura K., Nakano R., Watanabe M., Yashiro M., Nakamura T., Komai T., Kato K., Honda Y., Hiejima E., Yonezawa A., Bessho K., Okada S., Ohara O., Takita J., Yasumi T., Nishikomori R.

    Arthritis and Rheumatology     2024

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    Objective: We assess the clinical characteristics of patients with cryopyrin-associated periodic syndrome (CAPS) in Japan and evaluate the real-world efficacy and safety of interleukin-1 (IL-1) inhibitors, primarily canakinumab. Methods: Clinical information was collected retrospectively, and serum concentrations of canakinumab and cytokines were analyzed. Results: A total of 101 patients were included, with 86 and 15 carrying heterozygous germline and somatic mosaic mutations, respectively. We identified 39 mutation types, and the common CAPS-associated symptoms corresponded with those in previous reports. Six patients (5.9% of all patients) died, with four of the deaths caused by CAPS-associated symptoms. Notably, 73.7% of patients (100%, 79.6%, and 44.4% of familial cold autoinflammatory syndrome, Muckle–Wells syndrome, and chronic infantile neurological cutaneous articular syndrome/neonatal onset multisystem inflammatory disease, respectively) achieved complete remission with canakinumab, and early therapeutic intervention was associated with better auditory outcomes. In some patients, canakinumab treatment stabilized the progression of epiphysial overgrowth and improved height gain, visual acuity, and renal function. However, 23.7% of patients did not achieve inflammatory remission with crucial deterioration of organ damage, with two dying while receiving high-dose canakinumab treatment. Serological analysis of canakinumab and cytokine concentrations revealed that the poor response was not related to canakinumab shortage. Four inflammatory nonremitters developed inflammatory bowel disease (IBD)—unclassified during canakinumab treatment. Dual biologic therapy with canakinumab and anti–tumor necrosis factor-α agents was effective for IBD– and CAPS-associated symptoms not resolved by canakinumab monotherapy. Conclusion: This study provides one of the largest epidemiologic data sets for CAPS. Although early initiation of anti–IL-1 treatment with canakinumab is beneficial for improving disease prognosis, some patients do not achieve remission despite a high serum concentration of canakinumab. Moreover, IBD may develop in CAPS after canakinumab treatment. (Figure presented.).

    DOI： 10.1002/art.42808

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  16. Association between serum iron markers, iron supplementation and cardiovascular morbidity in pre-dialysis chronic kidney disease

    Hasegawa, T; Imaizumi, T; Hamano, T; Murotani, K; Fujii, N; Komaba, H; Ando, M; Maruyama, S; Nangaku, M; Nitta, K; Hirakata, H; Isaka, Y; Wada, T; Fukagawa, M

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 38 ( 12 ) page： 2713 - 2722   2023.12

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    Background: The optimal range of serum iron markers and usefulness of iron supplementation are uncertain in patients with pre-dialysis chronic kidney disease (CKD). We investigated the association between serum iron indices and risk of cardiovascular disease (CVD) events and the effectiveness of iron supplementation using Chronic Kidney Disease Japan Cohort data. Methods: We included 1416 patients ages 20-75 years with pre-dialysis CKD. The tested exposures were serum transferrin saturation and serum ferritin levels and the outcome measures were any cardiovascular event. Fine-Gray subdistribution hazard models were used to examine the association between serum iron indices and time to events. The multivariable fractional polynomial interaction approach was used to evaluate whether serum iron indices were effect modifiers of the association between iron supplementation and cardiovascular events. Results: The overall incidence rate of CVD events for a median of 4.12 years was 26.7 events/1000 person-years. Patients with serum transferrin saturation <20% demonstrated an increased risk of CVD [subdistribution hazard ratio (HR) 2.13] and congestive heart failure (subdistribution HR 2.42). The magnitude of reduction in CVD risk with iron supplementation was greater in patients with lower transferrin saturations (P =. 042). Conclusions: Maintaining transferrin saturation >20% and adequate iron supplementation may effectively reduce the risk of CVD events in patients with pre-dialysis CKD.

    DOI： 10.1093/ndt/gfad096

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  17. Hemifacial spasm caused by multiple vascular attachments due to remote compression effects of a dermoid cyst in the cerebellar hemisphere: illustrative case

    Hirayama K., Tanei T., Kato T., Hasegawa T., Ito E., Nishimura Y., Saito R.

    Journal of Neurosurgery: Case Lessons   Vol. 6 ( 23 )   2023.12

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    BACKGROUND Dermoid cysts located laterally in the posterior fossa are rare. The authors report the case of a dermoid cyst in the cerebellar hemisphere presenting with hemifacial spasm (HFS) caused by multiple vascular attachments due to remote compression effects. OBSERVATIONS A 48-year-old man presented with left HFS. Computed tomography showed a mass lesion in the left cerebellar hemisphere with calcification and erosion of skull bone. Magnetic resonance imaging showed no contrast enhancement of the lesion and a dural defect. The lesion compressed the brainstem and cerebellopontine cistern, but no vascular attachments to the facial nerve were seen. Tumor removal and microvascular decompression were performed. The lesion was composed of soft tissue containing oil-like liquid and hairs, and the border of the cerebellar arachnoid was clear. There were multiple vascular attachments to the root exit zone, facial nerve, and brainstem. After displacing these arteries, the intraoperative abnormal muscle response disappeared. Histopathological findings showed stratified squamous epithelium, keratin flakes, calcifications, and hairs. The HFS disappeared completely and has remained absent for 27 months. LESSONS The dermoid cyst originating from occipital bone compressed the cerebellar hemisphere, displacing multiple vessels and leading to HFS. Tumor removal and the removal of all vascular factors can completely resolve HFS.

    DOI： 10.3171/CASE23592

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  18. Wavelength dependence of ultraviolet light inactivation for SARS-CoV-2 omicron variants

    Fujimoto N., Nagaoka K., Tatsuno I., Oishi H., Tomita M., Hasegawa T., Tanaka Y., Matsumoto T.

    Scientific Reports   Vol. 13 ( 1 )   2023.12

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    Ultraviolet (UV) irradiation offers an effective and convenient method for the disinfection of pathogenic microorganisms. However, UV irradiation causes protein and/or DNA damage; therefore, further insight into the performance of different UV wavelengths and their applications is needed to reduce risks to the human body. In this paper, we determined the efficacy of UV inactivation of the SARS-CoV-2 omicron BA.2 and BA.5 variants in a liquid suspension at various UV wavelengths by the 50% tissue culture infection dose (TCID50) method and quantitative polymerase chain reaction (qPCR) assay. The inactivation efficacy of 220 nm light, which is considered safe for the human body, was approximately the same as that of health hazardous 260 nm light for both BA.2 and BA.5. Based on the inactivation rate constants determined by the TCID50 and qPCR methods versus the UV wavelength, the action spectra were determined, and BA.2 and BA.5 showed almost the same spectra. This result suggests that both variants have the same UV inactivation characteristics.

    DOI： 10.1038/s41598-023-36610-6

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  19. Hangman's Fracture in Geriatric Population: A Nationwide Multicenter Study in Japan

    Yunde, A; Furuya, T; Orita, S; Ohtori, S; Yokogawa, N; Nakashima, H; Segi, N; Funayama, T; Ikegami, S; Nakajima, H; Watanabe, K; Hasegawa, T; Tonomura, H; Terashima, Y; Hashimoto, K; Suzuki, N; Uei, H; Kiyasu, K; Tominaga, H; Sakai, D; Kaito, T; Inoue, G; Okada, S; Imagama, S; Kato, S

    GLOBAL SPINE JOURNAL     2023.11

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    Study Design: Retrospective multicenter study. Objectives: To investigate the treatments of the geriatric population with hangman’s fractures using a multicenter database under the Japan Association of Spine Surgeons with Ambition (JASA). Methods: The multicenter database included data from 1512 patients. We employed the Levine and Edwards classification for categorizing hangman’s fractures. The study incorporated epidemiological data, including the prevalence of hangman’s fractures, patient age, and follow-up duration. Bony fusion rates and length of hospitalization were recorded for Type I and Type II fractures, and the degree of neurological impairment was assessed. Results: Hangman’s fractures represented 62 cases, accounting for 7.4% of all cervical spine injuries. The patients had an average age of 76.6 ± 6.5 years, and the mean duration of follow-up was 21.5 ± 23.6 months. The study found that the bony fusion rate for hangman’s fractures in the geriatric population was 88.9%. Surgical treatment was associated with a shorter hospitalization period for Type II fractures compared to conservative treatment. Thirteen cases of hangman’s fractures in the geriatric population, accounting for 21%, were complicated by spinal cord injury. Conclusions: This is the largest study to date on hangman’s fractures in geriatric population ≥65 years. Type I and Type II fractures, according to the Levine and Edwards classification, had a bony fusion rate of up to 90%. In patients with Type II fractures, surgical treatment led to a shorter initial hospital stay. Geriatric patients are at risk of spinal cord injury due to hangman’s fractures.

    DOI： 10.1177/21925682231216925

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  20. Clonal Hematopoiesis Is Associated with Severe COVID-19 Enhancing Inflammatory Responses in Myeloid Cells

    Saiki, R; Edahiro, R; Sonehara, K; Wang, QS; Namkoong, H; Hasegawa, T; Tanaka, H; Azekawa, S; Chubachi, S; Namba, S; Yamamoto, K; Kakiuchi, N; Shiraishi, Y; Chiba, K; Tanaka, H; Makishima, H; Nannya, Y; Koike, R; Takano, T; Ishii, M; Kimura, A; Imoto, S; Miyano, S; Kanai, T; Fukunaga, K; Okada, Y; Ogawa, S

    BLOOD   Vol. 142   2023.11

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  21. Associations of calcium, phosphate and intact parathyroid hormone levels with mortality, residual kidney function and technical failure among patients on peritoneal dialysis

    Murashima M., Fujii N., Goto S., Hasegawa T., Abe M., Hanafusa N., Fukagawa M., Hamano T.

    Clinical Kidney Journal   Vol. 16 ( 11 ) page： 1957 - 1964   2023.11

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    Background. Associations of calcium, phosphate and intact parathyroid hormone (iPTH) levels with outcomes may be different between patients on peritoneal dialysis (PD) and hemodialysis (HD). The aim of the study is to evaluate these associations among PD patients. Methods. In this prospective cohort study on the Japan Renal Data Registry, adults on PD at the end of 2009 were included. The observation period was until the end of 2018 and the data were censored at the time of transplantation or transition to HD. Exposures were time-averaged or time-dependent albumin-corrected calcium (cCa), phosphate and iPTH levels. Outcomes were all-cause and cardiovascular mortality, transition to HD and urine output. Data were analyzed using Cox regression models or linear mixed-effects models and the results were shown as cubic spline curves. Results. Among 7393 patients, 590 deaths and 211 cardiovascular deaths were observed during a median follow-up of 3.0 years. Higher cCa and phosphate levels were associated with higher mortality. Lower cCa levels were associated with a faster decline, whereas lower phosphate was associated with a slower decline in urine output. Lower phosphate and iPTH levels were associated with a lower incidence of transition to HD. Conclusions. Among PD patients, the observed associations of cCa, phosphate and iPTH with mortality, residual kidney function and technical failure suggest that avoiding high cCa, phosphate and iPTH levels might improve outcomes.

    DOI： 10.1093/ckj/sfad223

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  22. Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome

    Aiba, I; Hayashi, Y; Shimohata, T; Yoshida, M; Saito, Y; Wakabayashi, K; Komori, T; Hasegawa, M; Ikeuchi, T; Tokumaru, AM; Sakurai, K; Murayama, S; Hasegawa, K; Uchihara, T; Toyoshima, Y; Saito, Y; Yabe, I; Tanikawa, S; Sugaya, K; Hayashi, K; Sano, T; Takao, M; Sakai, M; Fujimura, H; Takigawa, H; Adachi, T; Hanajima, R; Yokota, O; Miki, T; Iwasaki, Y; Kobayashi, M; Arai, N; Ohkubo, T; Yokota, T; Mori, K; Ito, M; Ishida, C; Tanaka, M; Idezuka, J; Kanazawa, M; Aoki, K; Aoki, M; Hasegawa, T; Watanabe, H; Hashizume, A; Niwa, H; Yasui, K; Ito, K; Washimi, Y; Mukai, E; Kubota, A; Toda, T; Nakashima, K

    BRAIN COMMUNICATIONS   Vol. 5 ( 6 ) page： fcad296   2023.11

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    The clinical presentation of corticobasal degeneration is diverse, while the background pathology of corticobasal syndrome is also heterogeneous. Therefore, predicting the pathological background of corticobasal syndrome is extremely difficult. Herein, we investigated the clinical findings and course in patients with pathologically, genetically and biochemically verified corticobasal degeneration and corticobasal syndrome with background pathology to determine findings suggestive of background disorder. Thirty-Two patients were identified as having corticobasal degeneration. The median intervals from the initial symptoms to the onset of key milestones were as follows: gait disturbance, 0.0 year; behavioural changes, 1.0 year; falls, 2.0 years; cognitive impairment, 2.0 years; speech impairment, 2.5 years; supranuclear gaze palsy, 3.0 years; urinary incontinence, 3.0 years; and dysphagia, 5.0 years. The median survival time was 7.0 years; 50% of corticobasal degeneration was diagnosed as corticobasal degeneration/corticobasal syndrome at the final presentation. Background pathologies of corticobasal syndrome (n = 48) included corticobasal degeneration (33.3%), progressive supranuclear palsy (29.2%) and Alzheimer's disease (12.5%). The common course of corticobasal syndrome was initial gait disturbance and early fall. In addition, corticobasal degeneration-corticobasal syndrome manifested behavioural change (2.5 years) and cognitive impairment (3.0 years), as the patient with progressive supranuclear palsy-corticobasal syndrome developed speech impairment (1.0 years) and supranuclear gaze palsy (6.0 years). The Alzheimer's disease-corticobasal syndrome patients showed cognitive impairment (1.0 years). The frequency of frozen gait at onset was higher in the corticobasal degeneration-corticobasal syndrome group than in the progressive supranuclear palsy-corticobasal syndrome group [P = 0.005, odds ratio (95% confidence interval): 31.67 (1.46-685.34)]. Dysarthria at presentation was higher in progressive supranuclear palsy-corticobasal syndrome than in corticobasal degeneration-corticobasal syndrome [P = 0.047, 6.75 (1.16-39.20)]. Pyramidal sign at presentation and personality change during the entire course were higher in Alzheimer's disease-corticobasal syndrome than in progressive supranuclear palsy-corticobasal syndrome [P = 0.011, 27.44 (1.25-601.61), and P = 0.013, 40.00 (1.98-807.14), respectively]. In corticobasal syndrome, decision tree analysis revealed that 'freezing at onset' or 'no dysarthria at presentation and age at onset under 66 years in the case without freezing at onset' predicted corticobasal degeneration pathology with a sensitivity of 81.3% and specificity of 84.4%. 'Dysarthria at presentation and age at onset over 61 years' suggested progressive supranuclear palsy pathology, and 'pyramidal sign at presentation and personality change during the entire course' implied Alzheimer's disease pathology. In conclusion, frozen gait at onset, dysarthria, personality change and pyramidal signs may be useful clinical signs for predicting background pathologies in corticobasal syndrome.

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  23. Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers

    Kobayashi, Y; Niida, A; Nagayama, S; Saeki, K; Haeno, H; Takahashi, KK; Hayashi, S; Ozato, Y; Saito, H; Hasegawa, T; Nakamura, H; Tobo, T; Kitagawa, A; Sato, K; Shimizu, D; Hirata, H; Hisamatsu, Y; Toshima, T; Yonemura, Y; Masuda, T; Mizuno, S; Kawazu, M; Kohsaka, S; Ueno, T; Mano, H; Ishihara, S; Uemura, M; Mori, M; Doki, Y; Eguchi, H; Oshima, M; Suzuki, Y; Shibata, T; Mimori, K

    BRITISH JOURNAL OF CANCER   Vol. 129 ( 7 ) page： 1105 - 1118   2023.10

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    Background: Intratumor heterogeneity (ITH) in microsatellite instability-high (MSI-H) colorectal cancer (CRC) has been poorly studied. We aimed to clarify how the ITH of MSI-H CRCs is generated in cancer evolution and how immune selective pressure affects ITH. Methods: We reanalyzed public whole-exome sequencing data on 246 MSI-H CRCs. In addition, we performed a multi-region analysis from 6 MSI-H CRCs. To verify the process of subclonal immune escape accumulation, a novel computational model of cancer evolution under immune pressure was developed. Results: Our analysis presented the enrichment of functional genomic alterations in antigen-presentation machinery (APM). Associative analysis of neoantigens indicated the generation of immune escape mechanisms via HLA alterations. Multiregion analysis revealed the clonal acquisition of driver mutations and subclonal accumulation of APM defects in MSI-H CRCs. Examination of variant allele frequencies demonstrated that subclonal mutations tend to be subjected to selective sweep. Computational simulations of tumour progression with the interaction of immune cells successfully verified the subclonal accumulation of immune escape mutations and suggested the efficacy of early initiation of an immune checkpoint inhibitor (ICI) -based treatment. Conclusions: Our results demonstrate the heterogeneous acquisition of immune escape mechanisms in MSI-H CRCs by Darwinian selection, providing novel insights into ICI-based treatment strategies.

    DOI： 10.1038/s41416-023-02395-8

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  24. Estimating gene-level false discovery probability improves eQTL statistical fine-mapping precision

    Wang, QBS; Edahiro, R; Namkoong, H; Hasegawa, T; Shirai, Y; Sonehara, K; Kumanogoh, A; Ishii, M; Koike, R; Kimura, A; Imoto, S; Miyano, S; Ogawa, S; Kanai, T; Fukunaga, K; Okada, Y

    NAR GENOMICS AND BIOINFORMATICS   Vol. 5 ( 4 ) page： lqad090   2023.10

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    Statistical fine-mapping prioritizes putative causal variants from a large number of candidate variants, and is widely used in expression quantitative loci (eQTLs) studies. In eQTL fine-mapping, the existence of causal variants for gene expression is not guaranteed, since the genetic heritability of gene expression explained by nearby (cis-) variants is limited. Here we introduce a refined fine-mapping algorithm, named Knockoff-Finemap combination (KFc). KFc estimates the probability that the causal variant(s) exist in the cis-window of a gene through construction of knockoff genotypes (i.e. a set of synthetic genotypes that resembles the original genotypes), and uses it to adjust the posterior inclusion probabilities (PIPs). Utilizing simulated gene expression data, we show that KFc results in calibrated PIP distribution with improved precision. When applied to gene expression data of 465 genotyped samples from the Japan COVID-19 Task Force (JCTF), KFc resulted in significant enrichment of a functional score as well as reporter assay hits in the top PIP bins. When combined with functional priors derived from an external fine-mapping study (GTEx), KFc resulted in a significantly higher proportion of hematopoietic trait putative causal variants in the top PIP bins. Our work presents improvements in the precision of a major fine-mapping algorithm.

    DOI： 10.1093/nargab/lqad090

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  25. Correction to: Denosumab-related osteonecrosis of the jaw after tooth extraction and the effects of a short drug holiday in cancer patients: a multicenter retrospective study (Osteoporosis International, (2021), 32, 11, (2323-2333), 10.1007/s00198-021-05995-3)

    Hasegawa T., Ueda N., Yamada S., Kato S., Iwata E., Hayashida S., Kojima Y., Shinohara M., Tojo I., Nakahara H., Yamaguchi T., Kirita T., Kurita H., Shibuya Y., Soutome S., Akashi M.

    Osteoporosis International   Vol. 34 ( 10 ) page： 1823 - 1825   2023.10

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    Publisher：Osteoporosis International  

    In Table 1 of this article, the data (18(46.2) and 54(55.7)) in the columns 2 and 3/row 48 (page 2326) headed “Drug holiday before tooth extraction, yes” were mistakenly listed. The correct expression is 10(40.0) and 18(38.3). In Table 1 of this article, the data (21(53.8) and 43(44.3)) in the column 2 and 3/row 49 (page 2326) headed “Drug holiday before tooth extraction, No” were mistakenly listed. The correct expression is 15(60.0) and 29(61.7). In Table 1 of this article, the data (P value: 0.347) in the column 4 /row 48 (page 2326) were mistakenly listed. The correct expression is 1.000. In Table 1 (continued) of this article, the data (24(61.5) and 51(52.6)) in the [column 2 and 3/row 26] (page 2327) headed “Preoperative antibiotics administration, yes” were mistakenly listed. The correct expression is 15(60.0) and 23(48.9). In Table 1 (continued) of this article, the data (15(38.5) and 46(47.4)) in the [column 2 and 3/row 27] (page 2327) headed “Preoperative antibiotics administration, No” were mistakenly listed. The correct expression is 10(40.0) and 24(51.1). In Table 1 (continued) of this article, the data (P value:0.446) in the [column 4 /row 28] (page 2327) were mistakenly listed. The correct expression is 0.460. (Table presented.) Errata Variable DRONJ P-value Present n (%) Absent n (%) Patients, n 25 (34.7) 47 (65.3) Stage 0 1 (4.0) - Stage 1 10 (40.0) - Stage 2 11 (44.0) - Stage 3 3 (12.0) - Sex Male 10 (40.0) 21 (43.1) 0.805 * Female 15 (60.0) 26 (56.9) Age Range (years) 44–82 41–85 Mean ± SD 66.3 ± 11.3 64.60 ± 12.2 0.534 ** Performance status 0 or 1 23 (92.0) 44 (93.6) 1.000 * 2 or 3 2 (8.0) 3 (6.4) Smoking history Yes 3 (12.0) 9 (19.1) 0.735* No 18 (72.0) 33 (70.2) Unknown 4 (16.0) 5 (10.6) Duration of oncologic doses of denosumab Range (months) 5–51 1–85 Mean ± SD 22.4 ± 13.5 13.7 ± 15.3 < 0.001** ≥ 18 months 16 (66.7) 10 (27.8) < 0.001* < 18 months 9 (33.3) 37 (72.2) Comorbidity or drug-induced risk factors Diabetes mellitus Yes 2 (8.0) 3 (6.4) 1.000* No 23 (92.0) 44 (93.6) Corticosteroid therapy Yes 4 (16.0) 8 (17.0) 1.000* No 21 (84.0) 39 (83.0) Additional chemotherapy Yes 17 (72.3) 34 (70.8) 0.787* No 8 (27.7) 13 (28.2) Type of cancer Breast cancer 8 (32.0) 12 (25.5) 0.171*** Prostate cancer 2 (8.0) 12 (25.5) Multiple myeloma 1 (4.0) 4 (8.5) Lung cancer 2 (8.0) 6 (12.8) Other 1 (4.0) 4 (8.5) Unknown 11 (44.0) 9 (19.1) Interval between tooth extraction and last denosumab injection Range (days) 1–283 2–272 Mean ± SD 66.0 ± 61.7 58.9 ± 63.5 0.367** Drug holiday before tooth extraction Yes 10 (40.0) 18 (38.3) 1.000* No 15 (60.0) 29 (61.7) Reason for tooth extraction Periapical periodontitis Yes 16 (64.0) 25 (56.9) 0.457* No 9 (36.0) 22 (43.1) P4 periodontitis Yes 3 (12.0) 10 (21.3) 0.521* No 22 (88.0) 37 (78.7) Pericoronitis Yes 4 (16.0) 2 (4.6) 0.173* No 21 (84.0) 45 (95.7) Jawbone Maxillary 10 (40.0) 23 (48.9) 0.881*** Mandibular 14 (56.0) 21 (44.7) Maxillary and mandibular 1 (4.0) 3 (6.4) Site of tooth extraction Anterior region 2 (8.0) 5 (10.6) 0.562*** Molar region 22 (88.0) 37 (78.7) Anterior and molar region 1 (4.0) 5 (10.6) Bone volume around tooth Adequate alveolar bone volume 19 (76.0) 31 (66.0) 0.432* Bone loss 6 (24.0) 16 (44.0) Pre-existing inflammation Yes 24 (96.0) 29 (61.7) 0.002* No 1 (4.0) 18 (38.3) Preoperative antibiotics administration Yes 15 (60.0) 23 (48.9) 0.460* No 10 (40.0) 24 (51.1) Number of teeth extracted Single 11 (44.0) 20 (42.6) 1.000* Multiple 14 (56.0) 27 (57.4) Additional surgical procedure Bone removal Yes 11 (44.0) 11 (23.4) 0.106* No 14 (56.0) 36 (76.6) Root amputation Yes 5 (20.0) 6 (12.8) 0.497* No 20 (80.0) 41 (87.2) Wound status after extraction Open 12 (48.0) 15 (31.9) 0.736*** Closed with suture 12 (48.0) 28 (59.6) Completely closed with relaxation incision or removal of bone edge 1 (4.0) 4 (8.5) *Fisher’s exact test, **Mann-Whitney U test, ***chi-squared test. DRONJ, denosumab-related osteonecrosis of the jaw; SD, standard deviation

    DOI： 10.1007/s00198-023-06833-4

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  26. Prognostic impact of respiratory dysfunction in elderly patients with cervical spinal cord injury and/or fractures: a multicenter survey

    Hirota, R; Terashima, Y; Ohnishi, H; Yamashita, T; Yokogawa, N; Sasagawa, T; Nakashima, H; Segi, N; Ito, S; Funayama, T; Eto, F; Yamaji, A; Watanabe, K; Nori, S; Takeda, K; Furuya, T; Yunde, A; Nakajima, H; Yamada, T; Hasegawa, T; Suzuki, H; Imajo, Y; Ikegami, S; Uehara, M; Tonomura, H; Sakata, M; Hashimoto, K; Onoda, Y; Kawaguchi, K; Haruta, Y; Suzuki, N; Kato, K; Uei, H; Sawada, H; Nakanishi, K; Misaki, K; Terai, H; Tamai, K; Kuroda, A; Inoue, G; Kakutani, K; Kakiuchi, Y; Kiyasu, K; Tominaga, H; Tokumoto, H; Iizuka, Y; Takasawa, E; Akeda, K; Takegami, N; Funao, H; Oshima, Y; Kaito, T; Sakai, D; Yoshii, T; Ohba, T; Otsuki, B; Seki, S; Miyazaki, M; Ishihara, M; Okada, S; Imagama, S; Kato, S

    EUROPEAN SPINE JOURNAL   Vol. 32 ( 10 ) page： 3522 - 3532   2023.10

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    Language：English   Publisher：European Spine Journal  

    Purpose: To investigate the impact of early post-injury respiratory dysfunction for neurological and ambulatory ability recovery in patients with cervical spinal cord injury (SCI) and/or fractures. Methods: We included 1,353 elderly patients with SCI and/or fractures from 78 institutions in Japan. Patients who required early tracheostomy and ventilator management and those who developed respiratory complications were included in the respiratory dysfunction group, which was further classified into mild and severe respiratory groups based on respiratory weaning management. Patient characteristics, laboratory data, neurological impairment scale scores, complications at injury, and surgical treatment were evaluated. We performed a propensity score-matched analysis to compare neurological outcomes and mobility between groups. Results: Overall, 104 patients (7.8%) had impaired respiratory function. In propensity score-matched analysis, the respiratory dysfunction group had a lower home discharge and ambulation rates (p = 0.018, p = 0.001, respectively), and higher rate of severe paralysis (p < 0.001) at discharge. At the final follow-up, the respiratory dysfunction group had a lower ambulation rate (p = 0.004) and higher rate of severe paralysis (p < 0.001). Twenty-six patients with severe disability required respiratory management for up to 6 months post-injury and died of respiratory complications. The mild and severe respiratory dysfunction groups had a high percentage of severe paraplegic cases with low ambulatory ability; there was no significant difference between them. The severe respiratory dysfunction group tended to have a poorer prognosis. Conclusion: Respiratory dysfunction in elderly patients with SCI and/or cervical fracture in the early post-injury period reflects the severity of the condition and may be a useful prognostic predictor.

    DOI： 10.1007/s00586-023-07828-9

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  27. A second update on mapping the human genetic architecture of COVID-19

    Kanai, M; Andrews, SJ; Cordioli, M; Stevens, C; Neale, BM; Daly, M; Ganna, A; Kanai, M; Andrews, SJ; Cordioli, M; Pathak, GA; Ganna, A; Iwasaki, A; Karjalainen, J; Mehtonen, J; Pathak, GA; Andrews, SJ; Kanai, M; Cordioli, M; Pirinen, M; Stevens, C; Chwialkowska, K; Trankiem, A; Balaconis, MK; Veerapen, K; Wolford, BN; Ahmad, HF; Andrews, S; Puoti, KAV; Boer, C; Boua, PR; Butler-Laporte, G; Cadilla, CL; Chwialkowska, K; Colombo, F; Douillard, V; Dueker, N; Dutta, AK; El-Sherbiny, YM; Eltoukhy, MM; Esmaeeli, S; Faucon, A; Fave, MJ; Cadenas, IF; Francescatto, M; Francioli, L; Franke, L; Fuentes, M; Durán, RG; Cabrero, DG; Harry, EN; Jansen, P; Szentpéteri, JL; Kaja, E; Kanai, M; Kirk, C; Kousathanas, A; Krieger, JE; Patel, SK; Lemaçon, A; Limou, S; Lió, P; Marouli, E; Marttila, MM; Medina-Gómez, C; Michaeli, Y; Migeotte, I; Mondal, S; Moreno-Estrada, A; Moya, L; Nakanishi, T; Nasir, J; Pasko, D; Pathak, GA; Pearson, NM; Pereira, AC; Priest, J; Prijatelj, V; Prokic, I; Teumer, A; Várnai, R; Romero-Gómez, M; Roos, C; Rosenfeld, J; Ruolin, L; Schulte, EC; Schurmann, C; Sedaghati-Khayat, B; Shaheen, D; Shivanathan, I; Sipeky, C; Sirui, Z; Striano, P; Tanigawa, Y; Remesal, AU; Vadgama, N; Vallerga, CL; Van der Laan, S; Verdugo, RA; Wang, QBS; Wei, Z; Zainulabid, UA; Zárate, RN; Auton, A; Shelton, JF; Shastri, AJ; Weldon, CH; Filshtein-Sonmez, T; Coker, D; Symons, A; Aslibekyan, S; O'Connell, J; Ye, C; Weldon, CH; Hatoum, AS; Agrawal, A; Bogdan, R; Colbert, SMC; Thompson, WK; Fan, CC; Johnson, EC; Niazyan, L; Davidyants, M; Arakelyan, A; Avetyan, D; Bekbossynova, M; Tauekelova, A; Tuleutayev, M; Sailybayeva, A; Ramankulov, Y; Zholdybayeva, E; Dzharmukhanov, J; Kassymbek, K; Tsechoeva, T; Turebayeva, G; Smagulova, Z; Muratov, T; Khamitov, S; Kwong, ASF; Timpson, NJ; Niemi, MEK; Rahmouni, S; Guntz, J; Migeotte, I; Beguin, Y; Cordioli, M; Pigazzini, S; Nkambule, L; Georges, M; Moutschen, M; Misset, B; Darcis, G; Gofflot, S; Bouysran, Y; Busson, A; Peyrassol, X; Wilkin, F; Pichon, B; Smits, G; Vandernoot, I; Goffard, JC; Tiembe, N; Nakanishi, T; Morrison, DR; Afilalo, J; Mooser, V; Richards, JB; Rousseau, S; Durand, M; Butler-Laporte, G; Forgetta, V; Laurent, L; Afrasiabi, Z; Bouab, M; Tselios, C; Xue, XQ; Afilalo, M; Oliveira, M; St-Cyr, J; Boisclair, A; Ragoussis, J; Auld, D; Kaufmann, DE; Lathrop, GM; Bourque, G; Décary, S; Falcone, EL; Montpetit, A; Piché, A; Renoux, C; Tremblay, K; Tse, SM; Zawati, MH; Davis, LK; Cox, NJ; Below, JE; Sealock, JM; Faucon, AB; Shuey, MM; Polikowsky, HG; Petty, LE; Shaw, DM; Chen, HH; Zhu, WY; Schmidt, A; Ludwig, KU; Maj, C; Rolker, S; Balla, D; Behzad, P; Nöthen, MM; Fazaal, J; Keitel, V; Keitel, V; Jensen, BEO; Feldt, T; Marx, N; Dreher, M; Pink, I; Cornberg, M; Illig, T; Lehmann, C; Schommers, P; Rybniker, J; Augustin, M; Knopp, L; Kurth, I; Eggermann, T; Volland, S; Berger, MM; Brenner, T; Hinney, A; Witzke, O; Konik, MJ; Bals, R; Herr, C; Ludwig, N; Walter, J; Latz, E; Schmidt, SV; Brooks, JD; Bull, S; Elliott, LT; Gagnon, F; Greenwood, CMT; Hung, RJ; Lawless, JF; Paterson, AD; Sun, L; Rauh, M; Briollais, L; Gingras, AC; Bombard, Y; Pugh, TJ; Simpson, J; Goneau, LW; Halevy, AR; Maslove, DM; Borgundvaag, B; Devine, L; Bearss, E; Richardson, D; Arnoldo, S; Friedman, SM; Taher, A; Stern, S; Dagher, M; Vasilevska-Ristovska, J; Biggs, CM; Mickiewicz, B; Strug, LJ; Scherer, SW; Aziz, N; Jones, SJM; Knoppers, BM; Lathrop, M; Turvey, SE; Yeung, RSM; Allen, U; Cheung, AM; Herridge, MS; Hunt, M; Lerner-Ellis, J; Taher, J; Parekh, RS; Hiraki, LT; Cowan, J; Ducharme, FM; Ostrowski, M; Bernier, FP; Kellner, J; Garg, E; Yoo, S; Vlasschaert, C; Frangione, E; Chung, M; Noor, A; Greenfeld, E; Colwill, K; Clausen, M; Chao, G; Yue, F; Fritzler, M; Whitney, J; Thiruvahindrapuram, B; Garant, JM; Abraham, R; Davis, A; Campigotto, A; Papenburg, J; Niranjan, K; Betschel, S; Sadarangani, M; Barton-Forbes, M; Hanley, M; Fung, CYJ; Lapadula, E; MacDonald, G; Puopolo, M; Kaushik, D; Nirmalanathan, K; Wong, I; Khan, Z; Zarei, N; Michalowska, M; Modi, BP; Persia, P; Estacio, A; Buchholz, M; Cheatley, PL; Lorenti, M; Aman, NF; Matveev, V; Budylowski, P; Upton, J; Morris, S; Boyd, T; Chowdhary, S; Casalino, S; Morgan, G; Mighton, C; McGeer, A; Mazzulli, T; McLeod, SL; Binnie, A; Faghfoury, H; Chertkow, H; Racher, H; Serbanescu, MA; Pavenski, K; Esser, M; Thompson, G; Herbrick, JA; Gignoux, CR; Wicks, SJ; Crooks, K; Barnes, KC; Daya, M; Shortt, J; Rafaels, N; Chavan, S; Ganna, A; Schulze, TG; Schulte, EC; Heilbronner, U; Papiol, S; Cordioli, M; Corbetta, A; Wendtner, CM; Spinner, CD; Erber, J; Schneider, J; Winter, C; Wiltfang, J; Budde, M; Senner, F; Kalman, JL; Protzer, U; Mueller, NS; Mousas, A; Liontos, A; Christaki, E; Milionis, H; Tsilidis, K; Asimakopoulos, A; Kanellopoulou, A; Markozannes, G; Biros, D; Milionis, O; Tsourlos, S; Athanasiou, L; Kolios, NG; Pappa, C; Papathanasiou, A; Pargana, E; Nasiou, M; Kosmidou, M; Rapti, I; Ntotsikas, E; Chaliasos, K; Ntzani, E; Evangelou, E; Gartzonika, K; Georgiou, I; Tzoulaki, I; Ellinghaus, D; Degenhardt, F; Cáceres, M; Juzenas, S; Lenz, TL; Albillos, A; Julià, A; Prati, D; Solligård, E; Garcia, F; Tran, F; Hanses, F; Baselli, G; Zoller, H; Holter, JC; Fernández, J; Barretina, J; Valenti, L; Bujanda, L; Romero-Gómez, M; Buti, M; D'Amato, M; Banales, JM; Rosenstiel, P; Koehler, P; Invernizzi, P; de Cid, R; Asselta, R; Schreiber, S; Duga, S; Hehr, U; Franke, A; Maya-Miles, D; Hov, JR; Karlsen, TH; Folseraas, T; Teles, A; Tanck, A; Gassner, C; Azuure, C; Wacker, EM; Uellendahl-Werth, F; Hemmrich-Stanisak, G; Elabd, H; Kässens, J; Arora, J; Lerga-Jaso, J; Wienbrandt, L; Rühlemann, MC; Wendorff, M; Basso, MEF; Vadla, MS; Wittig, M; Braun, N; Lenning, OB; Özer, O; Myhre, R; Raychaudhuri, S; Wesse, T; Albrecht, W; Yi, X; Ortiz, AB; de Salazar, A; Chercoles, AG; Palom, A; Ruiz, A; Garcia-Fernandez, AE; Blanco-Grau, A; Mantovani, A; Holten, AR; Bandera, A; Cherubini, A; Protti, A; Aghemo, A; Gerussi, A; Ramirez, A; Nebel, A; Barreira, A; Lleo, A; Kildal, AB; Biondi, A; Caballero-Garralda, A; Gori, A; Glück, A; Lind, A; Nolla, AC; Latiano, A; Fracanzani, AL; Peschuck, A; Cavallero, A; Dyrhol-Riise, AM; Ruello, A; Muscatello, A; Voza, A; Rando-Segura, A; Solier, A; Cortes, B; Mateos, B; Nafria-Jimenez, B; Schaefer, B; Bellinghausen, C; Ferrando, C; de la Horra, C; Quereda, C; Scollo, C; Lange, C; Hu, CZ; Paccapelo, C; Angelini, C; Cappadona, C; Bianco, C; Cea, C; Sancho, C; Hoff, DAL; Galimberti, D; Haschka, D; Jiménez, D; Pestaña, D; Toapanta, D; Muñiz-Diaz, E; Azzolini, E; Sandoval, E; Binatti, E; Scarpini, E; Casalone, E; Urrechaga, E; Paraboschi, EM; Pontali, E; Reverter, E; Calderón, EJ; Navas, E; Contro, E; Arana-Arri, E; Aziz, F; Sánchez, FG; Ceriotti, F; Martinelli-Boneschi, F; Peyvandi, F; Blasi, F; Malvestiti, F; Medrano, FJ; Mesonero, F; Rodriguez-Frias, F; Müller, F; Bellani, G; Pesenti, A; Zanella, A; Grasselli, G; Pezzoli, G; Costantino, G; Albano, G; Cardamone, G; Bellelli, G; Citerio, G; Foti, G; Lamorte, G; Matullo, G; Kurihara, H; Neb, H; My, I; Hernández, I; de Rojas, I; Galván-Femenia, I; Afset, JE; Heyckendorf, J; Damås, JK; Ampuero, J; Martín, J; Erdmann, J; Badia, JR; Dopazo, J; Bergan, J; Quero, JH; Goikoetxea, J; Delgado, J; Guerrero, JM; Risnes, K; Banasik, K; Müller, KE; Gaede, KI; Garcia-Etxebarria, K; Tonby, K; Heggelund, L; Bettini, LR; Sumoy, L; Terranova, L; Gustad, LT; Garbarino, L; Santoro, L; Téllez, L; Roade, L; Ostadreza, M; Intxausti, M; Kogevinas, M; Riveiro-Barciela, M; Schaefer, M; Gutiérrez-Stampa, MA; Carrabba, M; Valsecchi, MG; Hernandez-Tejero, M; Vehreschild, MJGT; Manunta, M; Acosta-Herrera, M; D'Angiò, M; Baldini, M; Cazzaniga, M; Marquie, M; Castoldi, M; Cecconi, M; Tomasi, M; Boada, M; Joannidis, M; Mazzocco, M; Ciccarelli, M; Rodríguez-Gandia, M; Bocciolone, M; Miozzo, M; Ayo, NI; Blay, N; Chueca, N; Montano, N; Martinez, N; Cornely, OA; Palmieri, O; Faverio, P; Preatoni, P; Bonfanti, P; Omodei, P; Tentorio, P; Castro, P; Rodrigues, PM; Izquierdo-Sanchez, L; España, PP; Hoffmann, P; Bacher, P; de Pablo, R; Ferrer, R; Gualtierotti, R; Gallego-Durán, R; Nieto, R; Carpani, R; Morilla, R; Badalamenti, S; Haider, S; Ciesek, S; Bombace, S; Marsal, S; Klein, S; Pelusi, S; Wilfling, S; Goerg, S; Bosari, S; Brunak, S; Heilmann-Heimbach, S; Aliberti, S; Dudman, S; Zheng, T; Bahmer, T; Pumarola, T; Cejudo, TG; Rimoldi, V; Monzani, V; Skogen, V; Friaza, V; Andrade, V; Moreno, V; Peter, W; Farre, X; Khodamoradi, Y; Grimsrud, MM; May, S; Colombo, A; Virginia, MRA; Dorador, C; Fuentes-Guajardo, M; Silva, AX; Espinosa-Parrilla, Y; Verdugo, RA; Yáñez, CE; Retamales-Ortega, RM; Hidalgo, JMS; Tobar-Calfucoy, EA; Carvajal-Silva, L; Martínez, MF; Cerpa, LC; Christian, MA; Cappelli, C; Valenzuela-Jorquera, H; Zapata-Contreras, D; Zuniga-Pacheco, P; Nova-Lamperti, EA; Sanhueza, SA; Donoso, G; Bocchieri, P; Kochifas, P; Quinones, LA; Banasik, K; Pedersen, OB; Geller, F; Westergaard, D; Sequeros, CB; Nissen, J; Nielsen, SD; Feldt-Rasmussen, U; Bliddal, S; Gronbaek, K; Brunak, S; Ullum, H; Ostrowski, SR; Feenstra, B; Niemi, MEK; Shahin, D; El-Sherbiny, YM; Puoti, KAV; Sobh, A; Eltoukhy, MM; Shoma, A; Cordioli, M; Corbetta, A; Nkambul, L; Elhadidy, TA; Abd Elghafar, MS; El-Jawhari, JJ; Mohamed, AAS; Elnagdy, MH; Samir, A; Abdel-Aziz, M; Khafaga, WT; El-Lawaty, WM; Torky, MS; El-Shanshory, MR; Elzeiny, A; Rashad, A; Mansour, TA; Yassen, AM; Hegazy, MAF; Okasha, K; Eid, MA; Hanteera, MS; Medina-Gomez, C; Ikram, MA; Uitterlinden, AG; Ripatti, S; Jermy, B; Ruotsalainen, S; Kristiansson, K; Koskelainen, S; Perola, M; Donner, K; Kivinen, K; Palotie, A; Kaunisto, M; Julienne, H; Aschard, H; Deleuze, JF; Debette, S; Tregouet, DA; Abel, L; Henches, L; Lefloch, E; Claire, DR; Sakuntabhai, A; Bourgeron, T; Olaso, R; Daian, DB; Pellegrin, I; Casanova, JL; Cobat, A; Jouanguy, E; Zhang, Q; Ghosn, J; Mentré, F; Laouénan, C; Tubiana, S; Chirouze, C; Quintana-Murci, L; Patin, E; Duffy, D; Boland, A; de Cid, R; Barretina, J; Carreras, A; Moreno, V; Kogevinas, M; Galván-Femenía, I; Blay, N; Farré, X; Sumoy, L; Cortés, B; Mercader, JM; 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Diaz-Olavarrieta, C; Valdés, PA; Muñóz-Hernández, LL; Mehta, RP; Elías-López, D; Tusié-Luna, T; Pajukanta, P; Sukhatme, MG; Moreno-Macías, H; Huerta-Chagoya, A; Ruth, J; Ochoa-Guzmán, A; González-Behn-Eschenburg, S; García-Grimshaw, M; Guillen-Pineda, LE; Vargas-Martínez, MD; Rodríguez, M; Rodríguez-Guillén, R; Ordoñez, ML; Segura-Kato, Y; Rajme-López, S; González-Lara, MF; Luna-Moreno, D; López, JDS; Guillén-Quintero, DM; Vega, J; Duran-Coyote, S; Guerra-García, MT; Durán-Gómez, M; Vigueras-Hernández, A; Ramírez-Jiménez, ME; Grajeda-González, SL; Ramos-Galicia, EM; Ramirez-Carrillo, MF; Fernandez-Ruiz, J; Chirino-Perez, A; Romero-Molina, AO; Zavaleta, DAF; Jaramillo, MAM; Lopez, KJP; Incontri-Abraham, D; Rosado, WN; Catalan, MA; Aguilar, SEV; Zamudio, IPM; Ruiz-Ruiz, E; Garcia, KDC; Guerrero, CV; Martinez, AIR; Moscoso-Sanchez, R; Mancilla, MDR; Villa, A; Luna-Ramirez, SA; Hernández-Hernández, S; Frias, E; Campos, A; Morales-Sosa, PA; Toxqui-Merchant, LE; García, K; Pasaniuc, B; Butte, MJ; Geschwind, DH; Aguilar-Salinas, CA; Heidecker, B; Kurth, F; Sander, LE; Skurk, C; Landmesser, U; Karadeniz, Z; Wang, XM; Poller, W; Suwalski, P; Ripke, S; Braun, A; Kraft, J; Mayer, A; Lippert, LJ; Helbig, ET; Thibeault, C; Awasthi, S; Mbarek, H; Ismail, SI; Saad, C; Al-Sarraj, Y; Badji, RM; Al-Muftah, W; Al Thani, A; Afifi, N; Sadiq, F; Khan, MI; Bhutta, MJ; Khan, H; Khan, M; Ain, Q; Junaid, A; Khan, EA; Sypniewski, M; Lejman, A; Zawadzki, P; Kaja, E; Sztromwasser, P; Król, Z; Dobosz, P; Stojak, J; Flores, C; Carracedo, A; Aguilar, C; Arana-Arri, E; Arranz, MJ; Baptista-Rosas, RC; Bezerra, JF; Bezerra, MAC; Brugada, R; Bustos, M; Calderón, EJ; Castano, L; Conde-Vicente, R; Cordero-Lorenzana, ML; De Martino-Rodríguez, A; Domínguez-Garrido, E; Fariñas, MC; Gil-Fournier, B; Herrero, MJ; Lattig, MC; Martin-López, C; Martín, V; Martinez-Nieto, O; Martinez-Lopez, I; Mazzeu, JF; Macías, EM; Cuerda, VM; Silbiger, VN; Oliveira, SF; Parellada, M; Santos, NPC; Pérez-Matute, P; Perez, P; Perucho, T; Porras-Hurtado, GL; Pujol, A; Fernández-Rodríguez, A; Jimenez-Sousa, MA; Rodríguez-Ruiz, E; Rodriguez-Artalejo, F; Rodriguez-Garcia, JA; Ruiz-Cabello, F; Soria, JM; Tamayo, E; Teper, A; Torres-Tobar, L; Urioste, M; Yáñez, Z; Zarate, R; Guillen-Navarro, E; Ayuso, C; González-Neira, A; Riancho, JA; Rojas-Martinez, A; Lapunzina, P; Cruz, R; Diz-de Almeida, S; Ceballos, FC; Lorenzo-Salazar, JM; González-Montelongo, R; Quintela, I; Pita, G; Gago-Domínguez, M; Porras, MS; Tenorio-Castaño, JA; Nevado, J; Aguado, JM; Aguilera-Albesa, S; Almadana, V; Almoguera, B; Alvarez, N; Andreu-Bernabeu, A; Arango, C; Artiga, MJ; Barreda-Sánchez, M; Belhassen-Garcia, M; Boix-Palop, L; Brion, M; Carbonell, C; Castelao, JE; Cortes-Sanchez, JL; Corton, M; Darnaude, MT; del Campo-Pérez, V; de Bustamante, AD; Luchessi, AD; Eiros, R; Sanabria, GME; Fernández-Robelo, U; Fernández-Villa, T; Gómez-Arrue, J; Alvarez, BG; de Quiros, FGB; González-Peñas, J; Gutiérrez-Bautista, JF; Herrero-Gonzalez, A; Borja, AL; Lopez-Rodriguez, R; Mancebo, E; Martinez-Resendez, MF; Martinez-Perez, A; Minguez, P; Ortega-Paino, E; Paz-Artal, E; Pérez-Tomás, ME; Pinsach-Abuin, M; Pompa-Mera, EN; León, SR; Resino, S; Fernandes, MR; Ruiz-Hornillos, J; Ryan, P; Souto, JC; Tamayo-Velasco, A; Taracido-Fernandez, JC; Valencia-Ramos, J; de Heredia, ML; Pedersen, OB; Erikstrup, C; Ostrowski, SR; Banasik, K; Brunak, S; Feenstra, B; Stefansson, K; Mikkelsen, S; Sorensen, E; Ullum, H; Westergaard, D; Burgos, C; Andersen, S; Brugdorf, K; Hansen, TF; Hjalgrim, H; Jemec, GB; Nyegaard, M; Werge, T; Johansson, PI; Didriksen, M; Geller, F; Schwinn, M; Jacobsen, RL; Hindhede, L; Rostgaard, K; Gudbjartsson, D; Stefánsson, H; Thorsteinsdóttir, U; Nielsen, KR; Bruun, MT; Dinh, KM; Larsen, MAH; Sækmose, SG; Niemi, MEK; Zeberg, H; Cordioli, M; Pigazzini, S; Nkambul, L; Frithiof, R; Hultström, M; Lipcsey, M; Tardif, N; Rooyackers, O; Grip, J; Maricic, T; Heid, IM; Wagner, R; Überla, K; Winkler, TW; Wiegrebe, S; Gorski, M; Stark, KJ; Peterhoff, D; Einhauser, S; Niller, HH; Beileke, S; Johnson, R; Pasaniuc, B; Butte, MJ; Freimer, N; Butte, MJ; Geschwind, DH; Pasaniuc, B; Ding, Y; Chiu, A; Chang, TS; Boutros, P; Nakanishi, T; Karczewski, KJ; Martin, AR; Wilson, DJ; Spencer, CCA; Crook, DW; Wyllie, DH; O'Connell, AM; Richards, JB; Butler-Laporte, G; Forgetta, V; Atkinson, EG; Kanai, M; Tsuo, K; Baya, N; Turley, P; Gupta, R; Walters, RK; Palmer, DS; Sarma, G; Solomonson, M; Cheng, N; Lu, WH; Churchhouse, C; Goldstein, JI; King, D; Zhou, W; Seed, C; Daly, MJ; Neale, BM; Finucane, H; Bryant, S; Satterstrom, FK; Band, G; Earle, SG; Lin, SK; Arning, N; Koelling, N; Armstrong, J; Rudkin, JK; Callier, S; Bryant, S; Cusick, C; Fernandez-Cadenas, I; Planas, AM; Perez-Tur, J; Llucià-Carol, L; Cullell, N; Muiño, E; Cárcel-Márquez, J; DeDiego, ML; Iglesias, LL; Soriano, A; Rico, V; Agüero, D; Bedini, JL; Lozano, F; Domingo, C; Robles, V; Ruiz-Jaén, F; Márquez, L; Gomez, J; Coto, E; Albaiceta, GM; García-Clemente, M; Dalmau, D; Arranz, MJ; Dietl, B; Serra-Llovich, A; Soler-Palacin, P; Colobran, R; Martin-Nalda, A; Parra-Martínez, A; Bernardo, D; Rojo, S; Fiz-López, A; Arribas-Rodriguez, E; Cal-Sabater, P; Segura, T; González-Villar, E; Serrano-Heras, G; Martí-Fàbregas, J; Jiménez-Xarrié, E; Mimbrera, AD; Masjuan, J; García-Madrona, S; Domínguez-Mayoral, A; Villalonga, JM; Menéndez-Valladares, P; Solomonson, M

    NATURE   Vol. 621 ( 7977 ) page： E7 - +   2023.9

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  28. Erratum to: Mapping the human genetic architecture of COVID-19 (Nature, (2021), 600, 7889, (472-477), 10.1038/s41586-021-03767-x)

    Niemi M.E.K., Karjalainen J., Liao R.G., Neale B.M., Daly M., Ganna A., Pathak G.A., Andrews S.J., Kanai M., Veerapen K., Fernandez-Cadenas I., Schulte E.C., Striano P., Marttila M., Minica C., Marouli E., Karim M.A., Wendt F.R., Savage J., Sloofman L., Butler-Laporte G., Kim H.N., Kanoni S., Okada Y., Byun J., Han Y., Uddin M.J., Smith G.D., Willer C.J., Buxbaum J.D., Mehtonen J., Finucane H., Cordioli M., Martin A.R., Zhou W., Pasaniuc B., Julienne H., Aschard H., Shi H., Yengo L., Polimanti R., Ghoussaini M., Schwartzentruber J., Dunham I., Chwialkowska K., Francescatto M., Trankiem A., Balaconis M.K., Davis L., Lee S., Priest J., Renieri A., Sankaran V.G., Van Heel D., Deelen P., Richards J.B., Nakanishi T., Biesecker L., Kerchberger V.E., Baillie J.K., Mari F., Bernasconi A., Ceri S., Canakoglu A., Wolford B., Faucon A., Dutta A.K., Schurmann C., Harry E., Birney E., Nguyen H., Nasir J., Kaunisto M., Solomonson M., Dueker N., Vadgama N., Limou S., Rahmouni S., Mbarek H., Darwish D., Uddin M.M., Albertos R., Pérez-Tur J., Li R., Folkersen L., Moltke I., Koelling N., Teumer A., Kousathanas A., Utrilla A., Verdugo R.A., Zárate R., Medina-Gómez C., Gómez-Cabrero D., Carnero-Montoro E., Cadilla C.L., Moreno-Estrada A., Garmendia A., Moya L., Sedaghati-Khayat B.

    Nature   Vol. 621 ( 7977 ) page： E7 - E26   2023.9

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    DOI： 10.1093/1476-4687

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  29. A revision of JPOS/JASCC clinical guidelines for delirium in adult cancer patients: a summary of recommendation statements

    Matsuda Y., Tanimukai H., Inoue S., Hirayama T., Kanno Y., Kitaura Y., Inada S., Sugano K., Yoshimura M., Harashima S., Wada S., Hasegawa T., Okamoto Y., Dotani C., Takeuchi M., Kako J., Sadahiro R., Kishi Y., Uchida M., Ogawa A., Inagaki M., Okuyama T.

    Japanese Journal of Clinical Oncology   Vol. 53 ( 9 ) page： 808 - 822   2023.9

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    Publisher：Japanese Journal of Clinical Oncology  

    Objective: The Japanese Psycho-Oncology Society and the Japanese Association of Supportive Care in Cancer have recently revised the clinical practice guidelines for delirium in adult cancer patients. This article reports the process of developing the revised guidelines and summarizes the recommendations made. Methods: The guidelines were developed in accordance with the Medical Information Network Distribution Service creation procedures. The guideline development group, consisting of multi-disciplinary members, created three new clinical questions: non-pharmacological intervention and antipsychotics for the prevention of delirium and trazodone for the management of delirium. In addition, systematic reviews of nine existing clinical questions have been updated. Two independent reviewers reviewed the proposed articles. The certainty of evidence and the strength of the recommendations were graded using the grading system developed by the Medical Information Network Distribution Service, following the concept of The Grading of Recommendations Assessment, Development, and Evaluation system. The modified Delphi method was used to validate the recommended statements. Results: This article provides a compendium of the recommendations along with their rationales, as well as a short summary. Conclusions: These revised guidelines will be useful for the prevention, assessment and management of delirium in adult cancer patients in Japan.

    DOI： 10.1093/jjco/hyad042

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  30. Difficult removal of totally implantable venous access devices in adult patients: Incidence, risk factors, and management

    Chatani, S; Tsukii, R; Nagasawa, K; Hasegawa, T; Murata, S; Kato, M; Yamaura, H; Onaya, H; Matsuo, K; Watanabe, Y; Inaba, Y

    JOURNAL OF VASCULAR ACCESS   Vol. 24 ( 5 ) page： 1150 - 1157   2023.9

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    Language：English   Publisher：Journal of Vascular Access  

    Background: Totally implantable venous access devices (TIVADs) have played an important role of medical oncology practice. However, operators sometimes encounter considerable difficulty when removing TIVADs. This study aimed to investigate the incidence of difficult TIVAD removal, determine associated risk factors, and investigate interventional radiology (IR) approaches to difficult removal. Methods: A total of 514 TIVAD removal procedures performed in a single-center between January 2014 and May 2021 were retrospectively analyzed to determine incidence of difficult removal and associated risk factors. IR approaches applied in difficult removal cases were also reviewed. Results: The incidence of difficult removal was 7.4% (38/514). In univariable analysis, indwelling duration, silicone catheter, and subcutaneous leakage of fluid were identified as significant risk factors for difficult removal. Multivariable analysis showed that indwelling duration per year (odds ratio (OR), 1.46; 95% confidence interval (CI), 1.28–1.67; p < 0.01) and subcutaneous leakage of fluid (OR, 6.04; 95% CI, 2.45–14.91; p < 0.01) were significantly associated with difficult removal. In the 38 difficult removal cases, 32 TIVADs could be removed using more dissection and traction than the standard removal method. In the other 6, TIVADs were successfully removed by using several IR techniques, including insertion of a guide wire (n = 1), dissection using an introducer sheath (n = 2), pushing with a dilator (n = 1), and pulling with a snare (n = 2). Conclusion: Difficult TIVAD removal is uncommon. However, operators should expect it when removing long indwelling TIVADs and those with subcutaneous leakage. IR approaches to difficult removal are minimally invasive and can be useful.

    DOI： 10.1177/11297298211069256

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  31. Mutation detection of urinary cell-free DNA via catch-and-release isolation on nanowires for liquid biopsy

    Takahashi, H; Yasui, T; Hirano, M; Shinjo, K; Miyazaki, Y; Shinoda, W; Hasegawa, T; Natsume, A; Kitano, Y; Ida, M; Zhang, M; Shimada, T; Paisrisarn, P; Zhu, ZT; Ohka, F; Aoki, K; Rahong, S; Nagashima, K; Yanagida, T; Baba, Y

    BIOSENSORS & BIOELECTRONICS   Vol. 234   page： 115318   2023.8

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    Language：English   Publisher：Biosensors and Bioelectronics  

    Cell-free DNA (cfDNA) and extracellular vesicles (EVs) are molecular biomarkers in liquid biopsies that can be applied for cancer detection, which are known to carry information on the necessary conditions for oncogenesis and cancer cell-specific activities after oncogenesis, respectively. Analyses for both cfDNA and EVs from the same body fluid can provide insights into screening and identifying the molecular subtypes of cancer; however, a major bottleneck is the lack of efficient and standardized techniques for the isolation of cfDNA and EVs from clinical specimens. Here, we achieved catch-and-release isolation by hydrogen bond-mediated binding of cfDNA in urine to zinc oxide (ZnO) nanowires, which also capture EVs by surface charge, and subsequently we identified genetic mutations in urinary cfDNA. The binding strength of hydrogen bonds between single-crystal ZnO nanowires and DNA was found to be equal to or larger than that of conventional hydrophobic interactions, suggesting the possibility of isolating trace amounts of cfDNA. Our results demonstrated that nanowire-based cancer screening assay can screen cancer and can identify the molecular subtypes of cancer in urine from brain tumor patients through EV analysis and cfDNA mutation analysis. We anticipate our method to be a starting point for more sophisticated diagnostic models of cancer screening and identification.

    DOI： 10.1016/j.bios.2023.115318

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  32. Specialized Palliative Care and Intensity of End-of-Life Care Among Adolescents and Young Adults with Cancer: A Medical Chart Review

    Hasegawa T., Ito Y., Furukawa Y., Okuyama T., Kojima N., Uchida M., Tasaki Y., Suzuki N., Ishida K., Kashima S., Kubota Y., Akechi T.

    Journal of Adolescent and Young Adult Oncology   Vol. 12 ( 4 ) page： 488 - 495   2023.8

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    Purpose: Adolescents and young adults (AYAs) with cancer often undergo aggressive end-of-life (EOL) care. We evaluated whether specialized palliative care (SPC) involvement is associated with the receipt of intensive EOL care among AYAs. Methods: This retrospective study included patients with cancer treated between the ages of 15 and 39 years at a university hospital, who died during 2009–2022. The primary outcome was high-intensity EOL (HI-EOL) care, which was defined as ≥1 session of intravenous chemotherapy <14 days from death or during the final 30 days of life, ≥1 hospitalization at an intensive care unit, >1 emergency room admission, or >1 hospitalization at an acute care unit during the final 30 days of life. We determined predictors of outcomes using multiple logistic regression models. Results: We analyzed 132 AYAs (75 with SPC involvement), of whom 42.4% (95% confidence interval [CI]: 33.9%–51.3%) underwent HI-EOL care. The prevalence of HI-EOL care was significantly lower in those who had SPC involvement than in those without SPC involvement (adjusted odds 0.30; 95% CI: 0.13–0.69; p = 0.005). Using no SPC involvement group as a reference, the adjusted odds for SPC involvement ≤60 days and >60 days were 0.71 (95% CI: 0.18–2.78; p = 0.63) and 0.22 (95% CI: 0.09–0.57; p = 0.002), respectively. Conclusion: In AYAs with cancer, SPC involvement and duration were associated with a lower incidence of HI-EOL care. Thus, integrating SPC into oncology may improve EOL care for AYAs.

    DOI： 10.1089/jayao.2022.0078

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  33. Opioids for the management of dyspnea in cancer patients: a systematic review and meta-analysis

    Takagi Y., Sato J., Yamamoto Y., Matsunuma R., Watanabe H., Mori M., Hasegawa T., Matsuda Y., Kako J., Kasahara Y., Goya S., Kohara H., Nakayama T., Yamaguchi T.

    International Journal of Clinical Oncology   Vol. 28 ( 8 ) page： 999 - 1010   2023.8

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    Publisher：International Journal of Clinical Oncology  

    Dyspnea is a prevalent symptom that significantly reduces quality of life of cancer patients. Palliative treatment is necessary when the symptoms do not respond to treatment for their cause. Opioids are widely used as pharmacological therapy, but evidence for individual agents is inconsistent. The purpose of this study was to evaluate the efficacy and safety of opioids for dyspnea in cancer patients. We searched the CENTRAL, MEDLINE, EMBASE, and ICHUSHI for studies using opioids for dyspnea in adult cancer patients reported by September 2019. Screening of the retrieved literature and assessment of risk of bias and outcomes were performed by two independent authors. A meta-analysis was performed on the primary endpoint, relief of dyspnea, and secondary endpoints including quality of life, somnolence as a side effect, and serious adverse events. Twelve randomized controlled trials were evaluated regarding relief of dyspnea. Somnolence and serious adverse events were evaluated in seven and four randomized controlled trials, respectively, but no randomized controlled trials were evaluable for quality of life. Overall, opioids were more effective than placebo for dyspnea (standardized mean difference − 0.43, 95% confidence interval [CI] − 0.75 to – 0.12). Although significant difference was found between systemic morphine and placebo in the drug-specific analysis, no significant difference could be detected in the other analyses. Systemic administration of opioids is more effective than placebo in relieving dyspnea in cancer patients. Robust evidence on the efficacy and safety of opioids on dyspnea in cancer patients is lacking, and further studies are needed.

    DOI： 10.1007/s10147-023-02362-6

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  34. Alternative, but expensive, energy transition scenario featuring carbon capture and utilization can preserve existing energy demand technologies

    Oshiro, K; Fujimori, S; Hasegawa, T; Asayama, S; Shiraki, H; Takahashi, K

    ONE EARTH   Vol. 6 ( 7 ) page： 872 - 883   2023.7

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    Publisher：One Earth  

    To reach net-zero carbon emissions, most climate change mitigation scenarios model a rapid transition from hydrocarbon-based energy to renewables, wide-scale electrification, and offsets to mitigate residual emissions. This requires phasing out existing hydrocarbon infrastructure and adjustments to electrification. Carbon capture and utilization (CCU) to produce synthetic fuels could be an alternative way to reach net zero while maintaining some existing energy infrastructure and minimizing the societal transition required, yet such scenarios remain unexamined. Here, we analyzed a CCU-based net-zero emissions scenario using a global energy system model. We find that synthetic fuel could meet 30% of energy demand by 2050, resulting in maintaining some existing technologies in energy demand sectors. Meanwhile, this scenario requires rapid upscaling of non-biomass renewables and direct air capture. The CCU-based scenario could be an alternative pathway; however, it involves multiple challenges related to technological feasibility and increased mitigation costs relative to net-zero scenarios using renewables, bioenergy, and carbon dioxide removal.

    DOI： 10.1016/j.oneear.2023.06.005

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  35. Prognosis of Cervical Diffuse Idiopathic Skeletal Hyperostosis-Related Spine Injuries in Elderly Patients: Analyses of Both Fracture and Spinal Cord Injury Without Fracture

    Segi, N; Nákashima, H; Machino, M; Ito, S; Yokogawa, N; Sasagawa, T; Funayama, T; Eto, F; Yamaji, A; Watanabe, K; Nori, S; Takeda, K; Furuya, T; Yunde, A; Nakajima, H; Yamada, T; Hasegawa, T; Terashima, Y; Hirota, R; Suzuki, H; Imajo, Y; Ikegami, S; Uehara, M; Tonomura, H; Sakata, M; Hashimoto, K; Onoda, Y; Kawaguchi, K; Haruta, Y; Suzuki, N; Kato, K; Uei, H; Sawada, H; Nakanishi, K; Misaki, K; Terai, H; Tamai, K; Shirasawa, E; Inoue, G; Kakutani, K; Kakiuchi, Y; Iizuka, Y; Takasawa, E; Akeda, K; Takegami, N; Kiyasu, K; Tominaga, H; Tokumoto, H; Funao, H; Oshima, Y; Yoshii, T; Kaito, T; Sakai, D; Ohba, T; Seki, S; Otsuki, B; Ishihara, M; Miyazaki, M; Okada, S; Imagama, S; Kato, S

    GLOBAL SPINE JOURNAL     page： 21925682231186757   2023.7

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    Study Design: Retrospective multicenter study. Objective: The purpose of this study was to compare the prognosis of elderly patients with injuries related to cervical diffuse idiopathic skeletal hyperostosis (cDISH) to matched control for each group, with and without fractures. Methods: The current multicenter study was a retrospective analysis of 140 patients aged 65 years or older with cDISH-related cervical spine injuries; 106 fractures and 34 spinal cord injuries without fracture were identified. Propensity score–matched cohorts from 1363 patients without cDISH were generated and compared. Logistic regression analysis was performed to determine the risk of early mortality for patients with cDISH-related injury. Results: Patients with cDISH-related injuries with fracture did not differ significantly in the incidence of each complication and ambulation or severity of paralysis compared to matched controls. In patients with cDISH-related injury without fracture, those who were nonambulatory at discharge comprised 55% vs 34% of controls, indicating significantly poorer ambulation in those with cDISH-related injuries (P =.023). There was no significant difference in the incidence of complications and ambulation or paralysis severity at 6 months as compared with controls. Fourteen patients died within 3 months. Logistic regression analysis identified complete paralysis (odds ratio [OR] 36.99) and age (OR 1.24) as significant risk factors for mortality. Conclusions: The current study showed no significant differences in the incidence of complications, ambulation outcomes between patients with cDISH-related injury with fracture and matched controls, and that the ambulation at discharge for patients with cDISH-related injury without fractures were significantly inferior to those of matched controls.

    DOI： 10.1177/21925682231186757

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  36. Search for Astrophysical Electron Antineutrinos in Super-Kamiokande with 0.01% Gadolinium-loaded Water

    Harada, M; Abe, K; Bronner, C; Hayato, Y; Hiraide, K; Hosokawa, K; Ieki, K; Ikeda, M; Kameda, J; Kanemura, Y; Kaneshima, R; Kashiwagi, Y; Kataoka, Y; Miki, S; Mine, S; Miura, M; Moriyama, S; Nakano, Y; Nakahata, M; Nakayama, S; Noguchi, Y; Okamoto, K; Sato, K; Sekiya, H; Shiba, H; Shimizu, K; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Watanabe, S; Yano, T; Han, S; Kajita, T; Okumura, K; Tashiro, T; Tomiya, T; Wang, X; Yoshida, S; Megias, GD; Fernandez, P; Labarga, L; Ospina, N; Zaldivar, B; Pointon, BW; Kearns, E; Raaf, JL; Wester, T; Bian, J; Griskevich, NJ; Locke, S; Smy, MB; Sobel, HW; Takhistov, V; Yankelevich, A; Hill, J; Lee, SH; Moon, DH; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Beauchêne, A; Drapier, O; Giampaolo, A; Mueller, TA; Santos, AD; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Choi, K; Iovine, N; Cao, S; Anthony, LHV; Martin, D; Scott, M; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Langella, A; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Mattiazzi, M; Ludovici, L; Gonin, M; Pronost, G; Fujisawa, C; Maekawa, Y; Nishimura, Y; Okazaki, R; Akutsu, R; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Jakkapu, M; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Bhuiyan, N; Burton, GT; Di Lodovico, F; Gao, J; Goldsack, A; Katori, T; Migenda, J; Xie, Z; Zsoldos, S; Kotsar, Y; Ozaki, H; Suzuki, AT; Takagi, Y; Takeuchi, Y; Feng, J; Feng, L; Hu, JR; Hu, Z; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Jenkins, SJ; McCauley, N; Mehta, P; Tarrant, A; Fukuda, Y; Itow, Y; Menjo, H; Ninomiya, K; Lagoda, J; Lakshmi, SM; Mandal, M; Mijakowski, P; Prabhu, YS; Zalipska, J; Jia, M; Jiang, J; Jung, CK; Wilking, MJ; Yanagisawa, C; Hino, Y; Ishino, H; Kitagawa, H; Koshio, Y; Nakanishi, F; Sakai, S; Tada, T; Tano, T; Barr, G; Barrow, D; Cook, L; Samani, S; Wark, D; Holin, A; Nova, F; Yang, BS; Yang, JY; Yoo, J; Fannon, JEP; Kneale, L; Malek, M; McElwee, JM; Thiesse, MD; Thompson, LF; Wilson, ST; Okazawa, H; Kim, SB; Kwon, E; Seo, JW; Yu, I; Ichikawa, AK; Nakamura, KD; Tairafune, S; Nishijima, K; Nakagiri, K; Nakajima, Y; Shima, S; Taniuchi, N; Watanabe, E; Yokoyama, M; de Perio, P; Martens, K; Tsui, KM; Vagins, MR; Xia, J; Kuze, M; Izumiyama, S; Matsumoto, R; Ishitsuka, M; Ito, H; Kinoshita, T; Matsumoto, R; Ommura, Y; Shigeta, N; Shinoki, M; Suganuma, T; Yamauchi, K; Martin, JF; Tanaka, HA; Towstego, T; Gaur, R; Gousy-Leblanc, V; Hartz, M; Konaka, A; Li, X; Prouse, NW; Chen, S; Xu, BD; Zhang, B; Posiadala-Zezula, M; Boyd, SB; Edwards, R; Hadley, D; Nicholson, M; O'Flaherty, M; Richards, B; Ali, A; Jamieson, B; Marti, L; Minamino, A; Pintaudi, G; Sano, S; Suzuki, S; Wada, K

    ASTROPHYSICAL JOURNAL LETTERS   Vol. 951 ( 2 )   2023.7

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    Publisher：Astrophysical Journal Letters  

    We report the first search result for the flux of astrophysical electron antineutrinos for energies(10)MeV in the gadolinium-loaded Super-Kamiokande (SK) detector. In 2020 June, gadolinium was introduced to the ultrapure water of the SK detector in order to detect neutrons more efficiently. In this new experimental phase, SK-Gd, we can search for electron antineutrinos via inverse beta decay with efficient background rejection thanks to the high efficiency of the neutron tagging technique. In this paper, we report the result for the initial stage of SK-Gd, during 2020 August 26, and 2022 June 1 with a 22.5 × 552 kton · day exposure at 0.01% Gd mass concentration. No significant excess over the expected background in the observed events is found for the neutrino energies below 31.3 MeV. Thus, the flux upper limits are placed at the 90% confidence level. The limits and sensitivities are already comparable with the previous SK result with pure water (22.5 × 2970 kton · day) owing to the enhanced neutron tagging. Operation with Gd increased to 0.03% started in 2022 June.

    DOI： 10.3847/2041-8213/acdc9e

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  37. The JCMT BISTRO Survey: Studying the Complex Magnetic Field of L43

    Karoly, J; Ward-Thompson, D; Pattle, K; Berry, D; Whitworth, A; Kirk, J; Bastien, P; Ching, TC; Coudé, S; Hwang, J; Kwon, W; Soam, A; Wang, JW; Hasegawa, T; Lai, SP; Qiu, KP; Arzoumanian, D; Bourke, TL; Byun, DY; Chen, HRV; Chen, WP; Chen, M; Chen, ZW; Cho, J; Choi, M; Choi, Y; Choi, Y; Chrysostomou, A; Chung, EJ; Dai, S; Debattista, V; Di Francesco, J; Diep, PN; Doi, Y; Duan, HY; Duan, Y; Eswaraiah, C; Fanciullo, L; Fiege, J; Fissel, LM; Franzmann, E; Friberg, P; Friesen, R; Fuller, G; Furuya, R; Gledhill, T; Graves, S; Greaves, J; Griffin, M; Gu, QL; Han, IL; Hoang, T; Houde, M; Hull, CLH; Inoue, T; Inutsuka, S; Iwasaki, K; Jeong, IG; Johnstone, D; Koenyves, V; Kang, JH; Kang, MJ; Kataoka, A; Kawabata, K; Kemper, F; Kim, J; Kim, S; Kim, G; Kim, KH; Kim, MR; Kim, KT; Kim, H; Kirchschlager, F; Kobayashi, MIN; Koch, PM; Kusune, T; Kwon, J; Lacaille, K; Law, CY; Lee, CW; Lee, HYS; Lee, YH; Lee, CF; Lee, JE; Lee, SS; Li, DL; Li, D; Li, GX; Li, HB; Lin, SJ; Liu, HL; Liu, T; Liu, SY; Liu, JH; Longmore, S; Lu, X; Lyo, AR; Mairs, S; Matsumura, M; Matthews, B; Moriarty-Schieven, G; Nagata, T; Nakamura, F; Nakanishi, H; Ngoc, NB; Ohashi, N; Onaka, T; Park, G; Parsons, H; Peretto, N; Priestley, F; Pyo, TS; Qian, L; Rao, RMS; Rawlings, J; Rawlings, M; Retter, B; Richer, J; Rigby, A; Sadavoy, S; Saito, H; Savini, G; Seta, M; Sharma, E; Shimajiri, Y; Shinnaga, H; Tahani, M; Tamura, M; Tang, YW; Tang, XD; Tomisaka, K; Tram, L; Tsukamoto, Y; Viti, S; Wang, HC; Wu, JT; Xie, JJ; Yang, MZ; Yen, HW; Yoo, H; Yuan, JH; Yun, HS; Zenko, T; Zhang, GY; Zhang, YP; Zhang, CP; Zhou, JJ; Zhu, L; de Looze, I; Andre, P; Dowell, CD; Eden, D; Eyres, S; Falle, S; Le Gouellec, VJM; Poidevin, F; Robitaille, JF; van Loo, S

    ASTROPHYSICAL JOURNAL   Vol. 952 ( 1 )   2023.7

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  38. Efficacy of supplemental oxygen for dyspnea relief in patients with advanced progressive illness: A systematic review and meta-analysis

    Hasegawa T., Ochi T., Goya S., Matsuda Y., Kako J., Watanabe H., Kasahara Y., Kohara H., Mori M., Nakayama T., Yamaguchi T.

    Respiratory Investigation   Vol. 61 ( 4 ) page： 418 - 437   2023.7

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    Publisher：Respiratory Investigation  

    Background: Supplemental oxygen is widely used for dyspnea relief; however, its efficacy is yet to be verified. This study aimed to determine the efficacy of supplemental oxygen for dyspnea relief in patients with advanced progressive illness. Methods: In this systematic review, several databases, including MEDLINE and EMBASE, were searched to identify eligible randomized controlled trials (RCTs) on the topic published up to September 23, 2019. The search criteria included RCTs investigating patients with advanced progressive illness (advanced cancer, chronic obstructive pulmonary disease, and chronic heart failure). The study protocol was registered with PROSPERO (No. CRD42020161838). Separate analyses were pre-planned regarding the presence or absence of resting hypoxemia. Results: RCTs investigating supplemental oxygen for dyspnea relief in participants with and without resting hypoxemia (39 and five, respectively) were included in the study. Heterogeneity of supplemental oxygen for dyspnea in RCTs, including participants without resting hypoxemia was evident; hence, post-hoc analyses in four subgroups (supplemental oxygen during exercise or daily activities, short-burst oxygen, continuous supplemental oxygen, and supplemental oxygen during rehabilitation intervention) were conducted. In the meta-analysis, supplemental oxygen during exercise was found to improve dyspnea in patients without resting hypoxemia compared with that in the control (standardized mean difference = −0.57, 95% confidence interval = −0.77 to −0.38). However, supplemental oxygen for the other subgroups failed to improve patients’ dyspnea. Conclusion: The results of this systematic review do not support supplemental oxygen therapy for dyspnea relief in patients with advanced progressive illness, except during exercise.

    DOI： 10.1016/j.resinv.2023.03.005

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  39. Identifying high-grade serous ovarian carcinoma-specific extracellular vesicles by polyketone-coated nanowires

    Yokoi, A; Ukai, M; Yasui, T; Inokuma, Y; Hyeon-Deuk, K; Matsuzaki, J; Yoshida, K; Kitagawa, M; Chattrairat, K; Iida, M; Shimada, T; Manabe, Y; Chang, IY; Asano-Inami, E; Koya, Y; Nawa, A; Nakamura, K; Kiyono, T; Kato, T; Hirakawa, A; Yoshioka, Y; Ochiya, T; Hasegawa, T; Baba, Y; Yamamoto, Y; Kajiyama, H

    SCIENCE ADVANCES   Vol. 9 ( 27 ) page： eade6958   2023.7

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    Language：English   Publisher：Science Advances  

    Cancer cell-derived extracellular vesicles (EVs) have unique protein profiles, making them promising targets as disease biomarkers. High-grade serous ovarian carcinoma (HGSOC) is the deadly subtype of epithelial ovarian cancer, and we aimed to identify HGSOC-specific membrane proteins. Small EVs (sEVs) and medium/large EVs (m/lEVs) from cell lines or patient serum and ascites were analyzed by LC-MS/MS, revealing that both EV subtypes had unique proteomic characteristics. Multivalidation steps identified FRα, Claudin-3, and TACSTD2 as HGSOC-specific sEV proteins, but m/lEV-associated candidates were not identified. In addition, for using a simple-to-use microfluidic device for EV isolation, polyketone-coated nanowires (pNWs) were developed, which efficiently purify sEVs from biofluids. Multiplexed array assays of sEVs isolated by pNW showed specific detectability in cancer patients and predicted clinical status. In summary, the HGSOC-specific marker detection by pNW are a promising platform as clinical biomarkers, and these insights provide detailed proteomic aspects of diverse EVs in HGSOC patients.

    DOI： 10.1126/sciadv.ade6958

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  40. Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma

    Kitagawa, A; Osawa, T; Noda, M; Kobayashi, Y; Aki, S; Nakano, Y; Saito, T; Shimizu, D; Komatsu, H; Sugaya, M; Takahashi, J; Kosai, K; Takao, S; Motomura, Y; Sato, K; Hu, QJ; Fujii, A; Wakiyama, H; Tobo, T; Uchida, H; Sugimachi, K; Shibata, K; Utsunomiya, T; Kobayashi, S; Ishii, H; Hasegawa, T; Masuda, T; Matsui, Y; Niida, A; Soga, T; Suzuki, Y; Miyano, S; Aburatani, H; Doki, Y; Eguchi, H; Mori, M; Nakayama, KI; Shimamura, T; Shibata, T; Mimori, K

    BRITISH JOURNAL OF CANCER   Vol. 128 ( 12 ) page： 2206 - 2217   2023.6

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    Language：English   Publisher：British Journal of Cancer  

    Background: Driver alterations may represent novel candidates for driver gene-guided therapy; however, intrahepatic cholangiocarcinoma (ICC) with multiple genomic aberrations makes them intractable. Therefore, the pathogenesis and metabolic changes of ICC need to be understood to develop new treatment strategies. We aimed to unravel the evolution of ICC and identify ICC-specific metabolic characteristics to investigate the metabolic pathway associated with ICC development using multiregional sampling to encompass the intra- and inter-tumoral heterogeneity. Methods: We performed the genomic, transcriptomic, proteomic and metabolomic analysis of 39–77 ICC tumour samples and eleven normal samples. Further, we analysed their cell proliferation and viability. Results: We demonstrated that intra-tumoral heterogeneity of ICCs with distinct driver genes per case exhibited neutral evolution, regardless of their tumour stage. Upregulation of BCAT1 and BCAT2 indicated the involvement of ‘Val Leu Ile degradation pathway’. ICCs exhibit the accumulation of ubiquitous metabolites, such as branched-chain amino acids including valine, leucine, and isoleucine, to negatively affect cancer prognosis. We revealed that this metabolic pathway was almost ubiquitously altered in all cases with genomic diversity and might play important roles in tumour progression and overall survival. Conclusions: We propose a novel ICC onco-metabolic pathway that could enable the development of new therapeutic interventions. [Figure not available: see fulltext.]

    DOI： 10.1038/s41416-023-02256-4

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  41. Does Adult Spinal Deformity Affect Cardiac Function? A Prospective Perioperative Study

    Mihara Y., Saitoh T., Hasegawa T., Yamato Y., Yoshida G., Banno T., Arima H., Oe S., Ide K., Yamada T., Kurosu K., Nakai K., Matsuyama Y.

    Spine   Vol. 48 ( 12 ) page： 832 - 842   2023.6

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    Publisher：Spine  

    Study Design. Prospective comparative study. Objective. The objective of this study was to investigate perioperative cardiac function using echocardiography in patients undergoing surgery for the adult spinal deformity (ASD). Summary of Background Data. Corrective surgery for ASD has increased, especially in older persons. However, perioperative complication rates remain high in ASD surgery, including cardiopulmonary complications. Materials and Methods. This study included patients with ASD who underwent surgery between May 2016 and April 2018. A cardiologist performed all echocardiography imaging preoperatively and 2 weeks postoperatively. Left ventricular contractility was measured using left ventricular ejection fraction (LVEF), and right ventricular contractility was measured using tricuspid annular plane systolic excursion (TAPSE) and tricuspid annular peak systolic velocity (S'). Spinopelvic radiographic parameters, the apices of thoracic kyphosis and lumbar lordosis, and the inflection point where the vertebral curvature changes from kyphosis to lordosis were also measured. Differences between preoperative and postoperative measurements for continuous variables were analyzed using a paired Student t test. Differences in continuous and categorical variables between two independent groups were analyzed using an unpaired Student t test and Fisher exact test, respectively. Multivariate logistic regression analyses were performed to detect influential factors. Results. Sixty-one patients were included [12 males and 49 females; average age, 64.0 (22-84) yr]. LVEF, TAPSE, and S', respectively changed from 64.4%, 24.9 mm, and 14.3 cm/s to 65.4%, 25 mm, and 15 cm/s postoperatively with no significance. However, in LVEF<59.3% (average-1 SD), TAPSE<17 mm, and S'<11.8 cm/s cases, respectively, these increased significantly from 55.7%, 17.9 mm, and 10.5 cm/s to 60.9%, 21.4 mm, and 14.2 cm/s postoperatively (P=0.036, 0.029, and 0.022, respectively). The LVEF<59.3% group showed a significantly lower inflection point level (1.5 vs. 2.9) preoperatively (P=0.007). The S'<11.8 cm/s group showed significantly larger thoracic kyphosis (28.3° vs. 19.4°) preoperatively (P=0.013). Conclusions. Perioperative cardiac function did not deteriorate after surgery in patients with ASD. In those with lower cardiac function preoperatively, there were significant improvements noted postoperatively. The preoperative inflection point level was significantly lower in the lower LVEF group. Preoperative thoracic kyphosis was significantly larger in the lower tricuspid annular peak systolic velocity group.

    DOI： 10.1097/BRS.0000000000004622

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  42. Blunt Cerebrovascular Injury in the Elderly With Traumatic Cervical Spine Injuries: Results of a Retrospective Multi-Center Study of 1512 Cases in Japan

    Suzuki H., Funaba M., Imajo Y., Yokogawa N., Sasagawa T., Ando K., Nakashima H., Segi N., Funayama T., Eto F., Watanabe K., Yamane J., Furuya T., Nakajima H., Hasegawa T., Terashima Y., Ikegami S., Inoue G., Kaito T., Kato S.

    Journal of Neurotrauma   Vol. 40 ( 11-12 ) page： 1164 - 1172   2023.6

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    Publisher：Journal of Neurotrauma  

    This study is nationwide retrospective multi-center study to investigate the incidence and characteristics of blunt cerebrovascular injury (BCVI) in elderly Japanese patients with traumatic cervical spine injuries (CSI) including spinal cord injury (SCI) without major bone injury. The study enrolled 1512 patients (average age: 75.8 ± 6.9 years; 1007 males, 505 females) from 33 nationwide institutions, and 391 (26%) of the participants had digital subtraction angiography and/or computed tomography angiography. Fifty-three patients were diagnosed as having BCVI by angiography. We assessed neurological evaluation, comorbidities and classification of CSI in the elderly patients with/without BCVI and collected 6-month follow-up data on treatment, complications, and patient outcome. We also statistically analyzed the relative risk (RR) and relationship between BCVI and other factors. Significant differences were identified between BCVI (+) (n = 53) and (-) (n = 1459) patients with American Spinal Injury Association Impairment Scale (ASIA) A, C, D, cervical fracture, C3-7 injury level (AO type F and/or C), cervical dislocation, spinal surgery for CSI, tetraplegia type of SCI, and/or head injury. Fifty-three (3.5%) elderly patients had CSI complicated by BCVI including 10 (19%) cases of Denver grade I, four (7%) of grade II, 1 (2%) of grade III, 29 (55%) of grade IV, and nine (17%) of grade V. Sixteen cases were treated by interventional radiology. Rates of mortality and brain infarction from BCVI were 0.13% and 0.40%, respectively. RR of BCVI was significantly higher in the elderly cervical injury patients with head injury, severe neurological deficit, ASIA A (RR: 4.33), cervical fracture at the C3-7 level (RR: 7.39), and cervical dislocation at the C1-6 level (RR: 3.06-7.18). In conclusion, 53 (3.5%) elderly patients were complicated with BCVI. BCVI more frequently complicated head injury, severe neurological deficit (ASIA A or tetraplegia), AO type F, and/or C fractures and cervical dislocation in these patients. Six patients (11%) suffered brain infarction and two patients died from BCVI.

    DOI： 10.1089/neu.2022.0180

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  43. Blunt Cerebrovascular Injury in the Elderly With Traumatic Cervical Spine Injuries: Results of a Retrospective Multi-Center Study of 1512 Cases in Japan

    Suzuki, H; Funaba, M; Imajo, Y; Yokogawa, N; Sasagawa, T; Ando, K; Nakashima, H; Segi, N; Funayama, T; Eto, F; Watanabe, K; Yamane, J; Furuya, T; Nakajima, H; Hasegawa, T; Terashima, Y; Ikegami, S; Inoue, G; Kaito, T; Kato, S

    JOURNAL OF NEUROTRAUMA   Vol. 40 ( 11-12 ) page： 1164 - 1172   2023.6

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  44. Current Management Options for Dyspnea in Cancer Patients

    Mori M., Miwa S., Ikari T., Kako J., Hasegawa T., Matsunuma R., Suzuki K., Matsuda Y., Watanabe H., Morita T., Yamaguchi T.

    Current Treatment Options in Oncology   Vol. 24 ( 6 ) page： 565 - 579   2023.6

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    Publisher：Current Treatment Options in Oncology  

    Dyspnea is one of the most frequent and distressing symptoms in patients with advanced cancer. As dyspnea deteriorates patients’ quality of life markedly and tends to worsen as the disease progresses, comprehensive assessment and timely treatment of the underlying etiologies are essential. International guidelines recommend various non-pharmacological and pharmacological management options. However, there is a scarcity of confirmatory clinical trials on cancer dyspnea, and the overall level of evidence is weak. Recently, observational and survey studies indicated a wide range of practice patterns of palliative care specialists, providing important insight into the real-world management of dyspnea. In this paper, we summarize current management options for dyspnea in cancer patients, highlight major controversies in the literature, and propose future research directions toward quality care for patients with dyspnea and their families.

    DOI： 10.1007/s11864-023-01081-4

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  45. Correction to: A multicenter retrospective study of the risk factors associated with medication-related osteonecrosis of the jaw after tooth extraction in patients receiving oral bisphosphonate therapy: can primary wound closure and a drug holiday really prevent MRONJ? (Osteoporosis International, (2017), 28, 8, (2465-2473), 10.1007/s00198-017-4063-7)

    Hasegawa T., Kawakita A., Ueda N., Funahara R., Tachibana A., Kobayashi M., Kondou E., Takeda D., Kojima Y., Sato S., Yanamoto S., Komatsubara H., Umeda M., Kirita T., Kurita H., Shibuya Y., Komori T.

    Osteoporosis International   Vol. 34 ( 6 ) page： 1141 - 1144   2023.6

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    Publisher：Osteoporosis International  

    In Table 2 (continued) of this article, the data (1874) in the [column 3/row 2] (page 2470, line 5) headed “Drug holiday before tooth extraction, 3-months, yes” were mistakenly listed. The correct expression is 1741. In Table 2 (continued) of this article, the data (543) in the [column 3/line 3] (page 2470, line 6) headed “Drug holiday before tooth extraction, 3-months, No” were mistakenly listed. The correct expression is 675.

    DOI： 10.1007/s00198-023-06745-3

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  46. Blunt Cerebrovascular Injury in the Elderly With Traumatic Cervical Spine Injuries: Results of a Retrospective Multi-Center Study of 1512 Cases in Japan.

    Suzuki H, Funaba M, Imajo Y, Yokogawa N, Sasagawa T, Ando K, Nakashima H, Segi N, Funayama T, Eto F, Watanabe K, Yamane J, Furuya T, Nakajima H, Hasegawa T, Terashima Y, Ikegami S, Inoue G, Kaito T, Kato S, Japan Association of Spine Surgeons with Ambition (JASA) Study Group

    Journal of neurotrauma   Vol. 40 ( 11-12 ) page： 1164 - 1172   2023.6

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    Language：English  

    DOI： 10.1089/neu.2022.0180

    PubMed

  47. Blunt Cerebrovascular Injury in the Elderly With Traumatic Cervical Spine Injuries: Results of a Retrospective Multi-Center Study of 1512 Cases in Japan

    Suzuki, H; Funaba, M; Imajo, Y; Yokogawa, N; Sasagawa, T; Ando, K; Nakashima, H; Segi, N; Funayama, T; Eto, F; Watanabe, K; Yamane, J; Furuya, T; Nakajima, H; Hasegawa, T; Terashima, Y; Ikegami, S; Inoue, G; Kaito, T; Kato, S

    JOURNAL OF NEUROTRAUMA   Vol. 40 ( 11-12 ) page： 1164 - 1172   2023.6

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  48. Measurement of the cosmogenic neutron yield in Super-Kamiokande with gadolinium loaded water

    Shinoki, M; Abe, K; Hayato, Y; Hiraide, K; Hosokawa, K; Ieki, K; Ikeda, M; Kameda, J; Kanemura, Y; Kaneshima, R; Kashiwagi, Y; Kataoka, Y; Miki, S; Mine, S; Miura, M; Moriyama, S; Nakano, Y; Nakahata, M; Nakayama, S; Noguchi, Y; Okamoto, K; Sato, K; Sekiya, H; Shiba, H; Shimizu, K; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Watanabe, S; Yano, T; Han, S; Kajita, T; Okumura, K; Tashiro, T; Tomiya, T; Wang, X; Yoshida, S; Megias, GD; Fernandez, P; Labarga, L; Ospina, N; Zaldivar, B; Pointon, BW; Kearns, E; Raaf, JL; Wan, L; Wester, T; Bian, J; Griskevich, NJ; Kropp, WR; Locke, S; Smy, MB; Sobel, HW; Takhistov, V; Yankelevich, A; Hill, J; Lee, SH; Moon, DH; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Beauchêne, A; Bernard, L; Coffani, A; Drapier, O; El Hedri, S; Giampaolo, A; Mueller, TA; Santos, AD; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Choi, K; Cao, S; Anthony, LHV; Martin, D; Scott, M; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Langella, A; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Mattiazzi, M; Ludovici, L; Gonin, M; Pronost, G; Fujisawa, C; Maekawa, Y; Nishimura, Y; Akutsu, R; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Jakkapu, M; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Bhuiyan, N; Boschi, T; Burton, GT; Di Lodovico, F; Gao, J; Goldsack, A; Katori, T; Migenda, J; Taani, M; Xie, Z; Zsoldos, S; Kotsar, Y; Ozaki, H; Suzuki, AT; Takeuchi, Y; Bronner, C; Feng, J; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Jenkins, SJ; McCauley, N; Mehta, P; Tarrant, A; Tsui, KM; Fukuda, Y; Itow, Y; Menjo, H; Ninomiya, K; Lagoda, J; Lakshmi, SM; Mandal, M; Mijakowski, P; Prabhu, YS; Zalipska, J; Jia, M; Jiang, J; Jung, CK; Wilking, MJ; Yanagisawa, C; Harada, M; Ishino, H; Ito, S; Kitagawa, H; Koshio, Y; Nakanish, F; Sakai, S; Barr, G; Barrow, D; Cook, L; Samani, S; Wark, D; Holin, A; Nova, F; Yang, JY; Yang, BS; Yoo, J; Fannon, JEP; Kneale, L; Malek, M; McElwee, JM; Stone, O; Thiesse, MD; Thompson, LF; Okazawa, H; Kim, SB; Kwon, E; Seo, JW; Yu, I; Ichikawa, AK; Nakamura, KD; Tairafune, S; Nishijima, K; Koshiba, M; Iwamoto, K; Nakagiri, K; Nakajima, Y; Shima, S; Taniuchi, N; Yokoyama, M; Martens, K; de Perio, P; Vagins, MR; Xia, J; Kuze, M; Izumiyama, S; Inomoto, M; Ishitsuka, M; Ito, H; Kinoshita, T; Matsumoto, R; Ommura, Y; Shigeta, N; Suganuma, T; Yamauchi, K; Martin, JF; Tanaka, HA; Towstego, T; Gaur, R; Gousy-Leblanc, V; Hartz, M; Konaka, A; Li, X; Prouse, NW; Chen, S; Xu, BD; Zhang, B; Posiadala-Zezula, M; Boyd, SB; Hadley, D; Nicholson, M; O'Flaherty, M; Richards, B; Ali, A; Jamieson, B; Marti, L; Minamino, A; Pintaudi, G; Sano, S; Suzuki, S; Wada, K

    PHYSICAL REVIEW D   Vol. 107 ( 9 )   2023.5

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    Cosmic-ray muons that enter the Super-Kamiokande detector cause hadronic showers due to spallation in water, producing neutrons and radioactive isotopes. These are a major background source for studies of MeV-scale neutrinos and searches for rare events. In 2020, gadolinium was introduced into the ultra-pure water in the Super-Kamiokande detector to improve the detection efficiency of neutrons. In this study, the cosmogenic neutron yield was measured using data acquired during the period after the gadolinium loading. The yield was found to be (2.76±0.02(stat)±0.19(syst))×10-4 μ-1 g-1 cm2 at an average muon energy 259 GeV at the Super-Kamiokande detector.

    DOI： 10.1103/PhysRevD.107.092009

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  49. Glycated albumin to glycated hemoglobin ratio and mortality in diabetic patients on dialysis: a new association

    Hoshino J., Abe M., Hamano T., Hasegawa T., Wada A., Nakai S., Hanafusa N., Masakane I., Nitta K.

    Nephrology Dialysis Transplantation   Vol. 38 ( 5 ) page： 1309 - 1317   2023.5

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    Background: Hemoglobin A1c (A1c) and glycated albumin (GA) are two blood glycated proteins commonly used to monitor glycemic control in dialysis patients with diabetes. However, little is known about the association between the GA/A1c ratio and mortality in these populations. Here, we examine these associations using a nationwide cohort. Methods: We enrolled 28 994 dialysis patients with diabetes who met our inclusion criteria (female, 32.9%; mean age, 67.4 ± 11.6 years; mean dialysis duration, 6.3 ± 5.8 years). After dividing the patients into groups based on GA/A1c quantiles and adjusting for 18 potential confounders, adjusted hazard ratios (HR) and 95% confidence limits were calculated for 3-year mortality and cause-specific mortalities. Additionally, propensity score matching analyses were used to compare mortalities between the low and high GA/A1c groups. Results: After adjusting for possible confounders, significantly increased mortality was found in patients with GA/A1c ratios of 3.6-4.0 [HR 1.21 (1.10-1.34)] or higher [HR 1.43 (1.30-1.58)] than in those with GA/A1c ratios of 3.0-3.3. The risks of infectious and cardiovascular death were higher in these patients regardless of their nutritional status. In the propensity score matching analyses, significantly increased mortality was consistently found in those with a higher ratio (≥3.3) [HR 1.23 (1.14-1.33)] than in those with a lower ratio. Conclusions: The GA/A1c ratio was significantly associated with 3-year mortality, especially infectious and cardiovascular mortality, in dialysis patients with diabetes. This ratio may be a promising new clinical indicator of survival in these patients, independent of their current glycemic control and nutritional markers.

    DOI： 10.1093/ndt/gfac297

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  50. <i>MORE</i><i> PANICLES</i> 3, a natural allele of<i> OsTB1/FC1,</i> impacts rice yield in paddy fields at elevated CO<sub>2</sub> levels

    Takai, T; Taniguchi, Y; Takahashi, M; Nagasaki, H; Yamamoto, E; Hirose, S; Hara, N; Akashi, H; Ito, J; Arai-Sanoh, Y; Hori, K; Fukuoka, S; Sakai, H; Tokida, T; Usui, Y; Nakamura, H; Kawamura, K; Asai, H; Ishizaki, T; Maruyama, K; Mochida, K; Kobayashi, N; Kondo, M; Tsuji, H; Tsujimoto, Y; Hasegawa, T; Uga, Y

    PLANT JOURNAL   Vol. 114 ( 4 ) page： 729 - 742   2023.5

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    Improving crop yield potential through an enhanced response to rising atmospheric CO2 levels is an effective strategy for sustainable crop production in the face of climate change. Large-sized panicles (containing many spikelets per panicle) have been a recent ideal plant architecture (IPA) for high-yield rice breeding. However, few breeding programs have proposed an IPA under the projected climate change. Here, we demonstrate through the cloning of the rice (Oryza sativa) quantitative trait locus for MORE PANICLES 3 (MP3) that the improvement in panicle number increases grain yield at elevated atmospheric CO2 levels. MP3 is a natural allele of OsTB1/FC1, previously reported as a negative regulator of tiller bud outgrowth. The temperate japonica allele advanced the developmental process in axillary buds, moderately promoted tillering, and increased the panicle number without negative effects on the panicle size or culm thickness in a high-yielding indica cultivar with large-sized panicles. The MP3 allele, containing three exonic polymorphisms, was observed in most accessions in the temperate japonica subgroups but was rarely observed in the indica subgroup. No selective sweep at MP3 in either the temperate japonica or indica subgroups suggested that MP3 has not been involved and utilized in artificial selection during domestication or breeding. A free-air CO2 enrichment experiment revealed a clear increase of grain yield associated with the temperate japonica allele at elevated atmospheric CO2 levels. Our findings show that the moderately increased panicle number combined with large-sized panicles using MP3 could be a novel IPA and contribute to an increase in rice production under climate change with rising atmospheric CO2 levels.

    DOI： 10.1111/tpj.16143

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  51. Secondary aneurysmal bone cyst of the frontal bone with fibrous dysplasia showing rapid expansion: a case report

    Koketsu, Y; Tanei, T; Kuwabara, K; Hasegawa, T; Kato, T; Maesawa, S; Nishimura, Y; Araki, Y; Saito, R

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 85 ( 2 ) page： 395 - 401   2023.5

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    Language：English   Publisher：Nagoya Journal of Medical Science  

    A 19-year-old woman presented with swelling of the left forehead without pain. She did not have any relevant past or family history. Computed tomography showed destruction of the outer cortex of the frontal bone. A solitary mass lesion with a fluid collection was detected with magnetic resonance imaging. Because the swelling of the left forehead had enlarged rapidly with osteolytic changes, surgical removal of the lesion was performed. The lesion appeared to be enveloped in a fibrous capsule. The soft lesion was removed from the frontal bone. The outer frontal bone was absent, although the inner frontal bone was preserved. Then, the frontal bone was resected with margins from the edge of the erosion. The dura mater under the lesion was intact. A cranioplasty was performed using titanium mesh. On histological examination, the trabecular bones revealed irregular shapes and arrangements, indicating fibrous dysplasia. There was a continuous high-cell-concentration pathological lesion outside the fibrous dysplasia. There were numerous cells, such as mononuclear cells, osteoclast-like multinucleated giant cells, foam cells, and red blood cells. The osteoclast-like multinucleated giant cells and other cells did not show significant nuclear atypia. Immunostaining with H3.3G34W was negative, and the ubiquitin-specific peptidase 6/Tre-2 gene showed no rearrangements. The histopathological diagnosis was secondary aneurysmal bone cyst with fibrous dysplasia. Additional postsurgical therapy was not performed. There has been no evidence of recurrence of the lesion for two years

    DOI： 10.18999/nagjms.85.2.395

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  52. Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

    Edahiro, R; Shirai, Y; Takeshima, Y; Sakakibara, S; Yamaguchi, Y; Murakami, T; Morita, T; Kato, Y; Liu, YC; Motooka, D; Naito, Y; Takuwa, A; Sugihara, F; Tanaka, K; Wing, JB; Sonehara, K; Tomofuji, Y; Namkoong, H; Tanaka, H; Lee, H; Fukunaga, K; Hirata, H; Takeda, Y; Okuzaki, D; Kumanogoh, A; Okada, Y; Wang, QBS; Edahiro, R; Namkoong, H; Hasegawa, T; Shirai, Y; Sonehara, K; Tanaka, H; Lee, H; Saiki, R; Hyugaji, T; Shimizu, E; Katayama, K; Kanai, M; Naito, T; Sasa, N; Yamamoto, K; Kato, Y; Morita, T; Takahashi, K; Harada, N; Naito, T; Hiki, M; Matsushita, Y; Takagi, H; Ichikawa, M; Nakamura, A; Harada, S; Sandhu, Y; Kabata, H; Masaki, K; Kamata, H; Ikemura, S; Chubachi, S; Okamori, S; Terai, H; Morita, A; Asakura, T; Sasaki, J; Morisaki, H; Uwamino, Y; Nanki, K; Uchida, S; Uno, S; Nishimura, T; Ishiguro, T; Isono, T; Shibata, S; Matsui, Y; Hosoda, C; Takano, K; Nishida, T; Kobayashi, Y; Takaku, Y; Takayanagi, N; Ueda, S; Tada, A; Miyawaki, M; Yamamoto, M; Yoshida, E; Hayashi, R; Nagasaka, T; Arai, S; Kaneko, Y; Sasaki, K; Tagaya, E; Kawana, M; Arimura, K; Takahashi, K; Anzai, T; Ito, S; Endo, A; Uchimura, Y; Miyazaki, Y; Honda, T; Tateishi, T; Tohda, S; Ichimura, N; Sonobe, K; Sassa, CT; Nakajima, J; Nakano, Y; Nakajima, Y; Anan, R; Arai, R; Kurihara, Y; Harada, Y; Nishio, K; Ueda, T; Azuma, M; Saito, R; Sado, T; Miyazaki, Y; Sato, R; Haruta, Y; Nagasaki, T; Yasui, Y; Hasegawa, Y; Mutoh, Y; Kimura, T; Sato, T; Takei, R; Hagimoto, S; Noguchi, Y; Yamano, Y; Sasano, H; Ota, S; Nakamori, Y; Yoshiya, K; Saito, F; Yoshihara, T; Wada, D; Iwamura, H; Kanayama, S; Maruyama, S; Yoshiyama, T; Ohta, K; Kokuto, H; Ogata, H; Tanaka, Y; Arakawa, K; Shimoda, M; Osawa, T; Tateno, H; Hase, I; Yoshida, S; Suzuki, S; Kawada, M; Horinouchi, H; Saito, F; Mitamura, K; Hagihara, M; Ochi, J; Uchida, T; Baba, R; Arai, D; Ogura, T; Takahashi, H; Hagiwara, S; Nagao, G; Konishi, S; Nakachi, I; Murakami, K; Yamada, M; Sugiura, H; Sano, H; Matsumoto, S; Kimura, N; Ono, Y; Baba, H; Suzuki, Y; Nakayama, S; Masuzawa, K; Namba, S; Shiroyama, T; Noda, Y; Niitsu, T; Adachi, Y; Enomoto, T; Amiya, S; Hara, R; Yamaguchi, Y; Murakami, T; Kuge, T; Matsumoto, K; Yamamoto, Y; Yamamoto, M; Yoneda, M; Tomono, K; Kato, K; Hirata, H; Takeda, Y; Koh, H; Manabe, T; Funatsu, Y; Ito, F; Fukui, T; Shinozuka, K; Kohashi, S; Miyazaki, M; Shoko, T; Kojima, M; Adachi, T; Ishikawa, M; Takahashi, K; Inoue, T; Hirano, T; Kobayashi, K; Takaoka, H; Watanabe, K; Miyazawa, N; Kimura, Y; Sado, R; Sugimoto, H; Kamiya, A; Kuwahara, N; Fujiwara, A; Matsunaga, T; Sato, Y; Okada, T; Hirai, Y; Kawashima, H; Narita, A; Niwa, K; Sekikawa, Y; Nishi, K; Nishitsuji, M; Tani, M; Suzuki, J; Nakatsumi, H; Ogura, T; Kitamura, H; Hagiwara, E; Murohashi, K; Okabayashi, H; Mochimaru, T; Nukaga, S; Satomi, R; Oyamada, Y; Mori, N; Baba, T; Fukui, Y; Odate, M; Mashimo, S; Makino, Y; Yagi, K; Hashiguchi, M; Kagyo, J; Shiomi, T; Fuke, STS; Saito, H; Tsuchida, T; Fujitani, S; Takita, M; Morikawa, D; Yoshida, T; Izumo, T; Inomata, M; Kuse, N; Awano, N; Tone, M; Ito, A; Nakamura, Y; Hoshino, K; Maruyama, J; Ishikura, H; Takata, T; Odani, T; Amishima, M; Hattori, T; Shichinohe, Y; Kagaya, T; Kita, T; Ohta, K; Sakagami, S; Koshida, K; Hayashi, K; Shimizu, T; Kozu, Y; Hiranuma, H; Gon, Y; Izumi, N; Nagata, K; Ueda, K; Taki, R; Hanada, S; Kawamura, K; Ichikado, K; Nishiyama, K; Muranaka, H; Nakamura, K; Hashimoto, N; Wakahara, K; Koji, S; Omote, N; Ando, A; Kodama, N; Kaneyama, Y; Maeda, S; Kuraki, T; Matsumoto, T; Yokote, K; Nakada, TA; Abe, R; Oshima, T; Shimada, T; Harada, M; Takahashi, T; Ono, H; Sakurai, T; Shibusawa, T; Kimizuka, Y; Kawana, A; Sano, T; Watanabe, C; Suematsu, R; Sageshima, H; Yoshifuji, A; Ito, K; Takahashi, S; Ishioka, K; Nakamura, M; Masuda, M; Wakabayashi, A; Watanabe, H; Ueda, S; Nishikawa, M; Chihara, Y; Takeuchi, M; Onoi, K; Shinozuka, J; Sueyoshi, A; Nagasaki, Y; Okamoto, M; Ishihara, S; Shimo, M; Tokunaga, Y; Kusaka, Y; Ohba, T; Isogai, S; Ogawa, A; Inoue, T; Fukuyama, S; Eriguchi, Y; Yonekawa, A; Kan-o, K; Matsumoto, K; Kanaoka, K; Ihara, S; Komuta, K; Inoue, Y; Chiba, S; Yamagata, K; Hiramatsu, Y; Kai, HRYS; Asano, K; Oguma, T; Ito, Y; Hashimoto, S; Yamasaki, M; Kasamatsu, Y; Komase, Y; Hida, N; Tsuburai, T; Oyama, B; Takada, M; Kanda, H; Kitagawa, Y; Fukuta, T; Miyake, T; Yoshida, S; Ogura, S; Abe, S; Kono, Y; Togashi, Y; Takoi, H; Kikuchi, R; Ogawa, S; Ogata, T; Ishihara, S; Kanehiro, A; Ozaki, S; Fuchimoto, Y; Wada, S; Fujimoto, N; Nishiyama, K; Terashima, M; Beppu, S; Yoshida, K; Narumoto, O; Nagai, H; Ooshima, N; Motegi, M; Umeda, A; Miyagawa, K; Shimada, H; Endo, M; Ohira, Y; Watanabe, M; Inoue, S; Igarashi, A; Sato, M; Sagara, H; Tanaka, A; Ohta, S; Kimura, T; Shibata, Y; Tanino, Y; Nikaido, T; Minemura, H; Sato, Y; Yamada, Y; Hashino, T; Shinoki, M; Iwagoe, H; Takahashi, H; Fujii, K; Kishi, H; Kanai, M; Imamura, T; Yamashita, T; Yatomi, M; Maeno, T; Hayashi, S; Takahashi, M; Kuramochi, M; Kamimaki, I; Tominaga, Y; Ishii, T; Utsugi, M; Ono, A; Tanaka, T; Kashiwada, T; Fujita, K; Saito, Y; Seike, M; Watanabe, H; Matsuse, H; Kodaka, N; Nakano, C; Oshio, T; Hirouchi, T; Makino, S; Egi, M; Omae, Y; Nannya, Y; Ueno, T; Takano, T; Katayama, K; Ai, MSM; Kumanogoh, A; Sato, T; Hasegawa, N; Tokunaga, K; Ishii, M; Koike, R; Kitagawa, Y; Kimura, A; Imoto, S; Miyano, S; Ogawa, S; Kanai, T; Fukunaga, K

    NATURE GENETICS   Vol. 55 ( 5 ) page： 753 - +   2023.5

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    Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral blood mononuclear cells from 73 coronavirus disease 2019 (COVID-19) patients and 75 healthy controls of Japanese ancestry with host genetic data. COVID-19 patients showed a low fraction of nonclassical monocytes (ncMono). We report downregulated cell transitions from classical monocytes to ncMono in COVID-19 with reduced CXCL10 expression in ncMono in severe disease. Cell–cell communication analysis inferred decreased cellular interactions involving ncMono in severe COVID-19. Clonal expansions of BCR were evident in the plasmablasts of patients. Putative disease genes identified by COVID-19 genome-wide association study showed cell type-specific expressions in monocytes and dendritic cells. A COVID-19-associated risk variant at the IFNAR2 locus (rs13050728) had context-specific and monocyte-specific expression quantitative trait loci effects. Our study highlights biological and host genetic involvement of innate immune cells in COVID-19 severity.

    DOI： 10.1038/s41588-023-01375-1

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  53. First BISTRO Observations of the Dark Cloud Taurus L1495A-B10: The Role of the Magnetic Field in the Earliest Stages of Low-mass Star Formation

    Ward-Thompson, D; Karoly, J; Pattle, K; Whitworth, A; Kirk, J; Berry, D; Bastien, P; Ching, TC; Coudé, S; Hwang, J; Kwon, W; Soam, A; Wang, JW; Hasegawa, T; Lai, SP; Qiu, KP; Arzoumanian, D; Bourke, TL; Byun, D; Chen, HRV; Chen, WP; Chen, MK; Chen, ZW; Cho, JY; Choi, M; Choi, Y; Choi, Y; Chrysostomou, A; Chung, EJ; Dai, SP; Debattista, V; Di Francesco, J; Diep, PN; Doi, Y; Duan, HY; Duan, Y; Eswaraiah, C; Fanciullo, L; Fiege, J; Fissel, LM; Franzmann, E; Friberg, P; Friesen, R; Fuller, G; Furuya, R; Gledhill, T; Graves, S; Greaves, J; Griffin, M; Gu, QL; Han, IL; Hayashi, S; Hoang, T; Houde, M; Hull, CLH; Inoue, T; Inutsuka, S; Iwasaki, K; Jeong, I; Johnstone, D; Könyves, V; Kang, JH; Kang, MJ; Kataoka, A; Kawabata, K; Kemper, F; Kim, J; Kim, S; Kim, G; Kim, KH; Kim, MR; Kim, KT; Kim, H; Kirchschlager, F; Kobayashi, MIN; Koch, PM; Kusune, T; Kwon, J; Lacaille, K; Law, CY; Lee, CW; Lee, HYS; Lee, YH; Lee, CF; Lee, JE; Lee, SS; Li, DL; Li, D; Li, GX; Li, HB; Lin, SJ; Liu, HL; Liu, T; Liu, SY; Liu, JH; Longmore, S; Lu, X; Lyo, AR; Mairs, S; Matsumura, M; Matthews, B; Moriarty-Schieven, G; Nagata, T; Nakamura, F; Nakanishi, H; Ngoc, NB; Ohashi, N; Onaka, T; Park, G; Parsons, H; Peretto, N; Priestley, F; Pyo, TS; Qian, L; Rao, RMS; Rawlings, J; Rawlings, M; Retter, B; Richer, J; Rigby, A; Sadavoy, S; Saito, H; Savini, G; Seta, M; Shimajiri, Y; Shinnaga, H; Tahani, M; Tamura, M; Tang, YW; Tang, XD; Tomisaka, K; Tram, L; Tsukamoto, Y; Viti, S; Wang, HC; Wu, JT; Xie, JJ; Yang, MZ; Yen, HW; Yoo, H; Yuan, JH; Yun, HS; Zenko, T; Zhang, GY; Zhang, YP; Zhang, CP; Zhou, JJ; Zhu, L; de Looze, I; André, P; Dowell, CD; Eden, D; Eyres, S; Falle, S; Le Gouellec, VJM; Poidevin, F; Robitaille, JF; van Loo, S

    ASTROPHYSICAL JOURNAL   Vol. 946 ( 2 )   2023.4

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  54. Delirium Risk Score in Elderly Patients with Cervical Spinal Cord Injury and/or Cervical Fracture

    Tamai, K; Terai, H; Nakamura, H; Yokogawa, N; Sasagawa, T; Nakashima, H; Segi, N; Ito, S; Funayama, T; Eto, F; Yamaji, A; Watanabe, K; Yamane, J; Takeda, K; Furuya, T; Yunde, A; Nakajima, H; Yamada, T; Hasegawa, T; Terashima, Y; Hirota, R; Suzuki, H; Imajo, Y; Ikegami, S; Uehara, M; Tonomura, H; Sakata, M; Hashimoto, K; Onoda, Y; Kawaguchi, K; Haruta, Y; Suzuki, N; Kato, K; Uei, H; Sawada, H; Nakanishi, K; Misaki, K; Kuroda, A; Inoue, G; Kakutani, K; Kakiuchi, Y; Kiyasu, K; Tominaga, H; Tokumoto, H; Iizuka, Y; Takasawa, E; Akeda, K; Takegami, N; Funao, H; Oshima, Y; Kaito, T; Sakai, D; Yoshii, T; Ohba, T; Otsuki, B; Seki, S; Miyazaki, M; Ishihara, M; Okada, S; Imagama, S; Kato, S

    JOURNAL OF CLINICAL MEDICINE   Vol. 12 ( 6 )   2023.3

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    Language：English   Publisher：Journal of Clinical Medicine  

    The number of elderly patients with cervical trauma is increasing. Such patients are considered to be at high risk for delirium, which is an acute neuropsychological disorder that reduces the patient’s capacity to interact with their environment due to impairments in cognition. This study aimed to establish a risk score that predicts delirium in elderly patients with cervical SCI and/or cervical fracture regardless of treatment type. This retrospective cohort study included 1512 patients aged ≥65 years with cervical SCI and/or cervical fracture. The risk factors for delirium according to treatment type (surgical or conservative) were calculated using multivariate logistic regression. A delirium risk score was established as the simple arithmetic sum of points assigned to variables that were significant in the multivariate analyses. Based on the statistical results, the delirium risk score was defined using six factors: old age (≥80 years), hypoalbuminemia, cervical fracture, major organ injury, dependence on pre-injury mobility, and comorbid diabetes. The score’s area under the curve for the prediction of delirium was 0.66 (p < 0.001). Although the current scoring system must be validated with an independent dataset, the system remains beneficial because it can be used after screening examinations upon hospitalization and before deciding the treatment strategy.

    DOI： 10.3390/jcm12062387

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  55. Effects of Dementia on Outcomes after Cervical Spine Injuries in Elderly Patients: Evaluation of 1512 Cases in a Nationwide Multicenter Study in Japan

    Yamada, Y; Yokogawa, N; Kato, S; Sasagawa, T; Tsuchiya, H; Nakashima, H; Segi, N; Ito, S; Funayama, T; Eto, F; Yamaji, A; Yamane, J; Nori, S; Furuya, T; Yunde, A; Nakajima, H; Yamada, T; Hasegawa, T; Terashima, Y; Hirota, R; Suzuki, H; Imajo, Y; Ikegami, S; Uehara, M; Tonomura, H; Sakata, M; Hashimoto, K; Onoda, Y; Kawaguchi, K; Haruta, Y; Suzuki, N; Kato, K; Uei, H; Sawada, H; Nakanishi, K; Misaki, K; Terai, H; Tamai, K; Kuroda, A; Inoue, G; Kakutani, K; Kakiuchi, Y; Kiyasu, K; Tominaga, H; Tokumoto, H; Iizuka, Y; Takasawa, E; Akeda, K; Takegami, N; Funao, H; Oshima, Y; Kaito, T; Sakai, D; Yoshii, T; Ohba, T; Otsuki, B; Seki, S; Miyazaki, M; Ishihara, M; Okada, S; Imagama, S; Watanabe, K

    JOURNAL OF CLINICAL MEDICINE   Vol. 12 ( 5 )   2023.3

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    We aimed to retrospectively investigate the demographic characteristics and short-term outcomes of traumatic cervical spine injuries in patients with dementia. We enrolled 1512 patients aged ≥ 65 years with traumatic cervical injuries registered in a multicenter study database. Patients were divided into two groups according to the presence of dementia, and 95 patients (6.3%) had dementia. Univariate analysis revealed that the dementia group comprised patients who were older and predominantly female and had lower body mass index, higher modified 5-item frailty index (mFI-5), lower pre-injury activities of daily living (ADLs), and a larger number of comorbidities than patients without dementia. Furthermore, 61 patient pairs were selected through propensity score matching with adjustments for age, sex, pre-injury ADLs, American Spinal Injury Association Impairment Scale score at the time of injury, and the administration of surgical treatment. In the univariate analysis of the matched groups, patients with dementia had significantly lower ADLs at 6 months and a higher incidence of dysphagia up to 6 months than patients without dementia. Kaplan–Meier analysis revealed that patients with dementia had a higher mortality than those without dementia until the last follow-up. Dementia was associated with poor ADLs and higher mortality rates after traumatic cervical spine injuries in elderly patients.

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  56. Usefulness of SynCAM3 and cyclin D1 immunohistochemistry in distinguishing superficial CD34-positive fibroblastic tumor from its histological mimics

    Sugita S., Takenami T., Kido T., Aoyama T., Hosaka M., Segawa K., Sugawara T., Fujita H., Murahashi Y., Emori M., Tsuyuki A., Hasegawa T.

    Medical Molecular Morphology   Vol. 56 ( 1 ) page： 69 - 77   2023.3

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    Superficial CD34-positive fibroblastic tumor (SCPFT) is a fibroblastic/myofibroblastic soft tissue tumor of rarely metastasizing intermediate malignancy. Some recent studies have described a relationship between SCPFT and PRDM10-rearranged soft tissue tumor (PRT) based on SynCAM3 and PRDM10 expression on immunohistochemistry. We performed CD34, cytokeratin AE1/AE3, SynCAM3, and PRDM10 immunohistochemistry in SCPFT and its histological mimics, including myxoinflammatory fibroblastic sarcoma (MIFS), superficially localized myxofibrosarcoma (MFS), and undifferentiated pleomorphic sarcoma. We also examined cyclin D1 expression because it is expressed in MIFS and MFS. We conducted fluorescence in situ hybridization (FISH) of PRDM10 rearrangement in SCPFT cases. On immunohistochemistry, only SCPFT showed strong and diffuse SynCAM3 expression. SCPFT also exhibited strong nuclear and weak cytoplasmic cyclin D1 expression, which was similar to that observed in MIFS. Two of five SCPFT cases exhibited nuclear PRDM10 expression. FISH revealed PRDM10 split signals in 44% and 24% of tumor cells in two SCPFT cases showing nuclear PRDM10 expression on immunohistochemistry, respectively. A minority of non-SCPFT cases showed focal SynCAM3 expression, but a combination of SynCAM3 and cyclin D1 in addition to CD34 and cytokeratin AE1/AE3 may be useful for the differential diagnosis of SCPFT and its histological mimics.

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  57. Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament

    Okuwaki, S; Funayama, T; Koda, M; Eto, F; Yamaji, A; Yokogawa, N; Sasagawa, T; Ando, K; Nakashima, H; Segi, N; Watanabe, K; Nori, S; Takeda, K; Furuya, T; Yunde, A; Nakajima, H; Yamada, T; Hasegawa, T; Terashima, Y; Hirota, R; Suzuki, H; Imajo, Y; Ikegami, S; Uehara, M; Tonomura, H; Sakata, M; Hashimoto, K; Onoda, Y; Kawaguchi, K; Haruta, Y; Suzuki, N; Kato, K; Uei, H; Sawada, H; Nakanishi, K; Misaki, K; Terai, H; Tamai, K; Shirasawa, E; Inoue, G; Kakutani, K; Kakiuchi, Y; Kiyasu, K; Tominaga, H; Tokumoto, H; Iizuka, Y; Takasawa, E; Akeda, K; Takegami, N; Funao, H; Oshima, Y; Kaito, T; Sakai, D; Yoshii, T; Ohba, T; Otsuki, B; Seki, S; Miyazaki, M; Ishihara, M; Okada, S; Imagama, S; Kato, S

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page： 2689   2023.2

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    Although the incidence of cervical spinal cord injury (CSCI) with ossification of the posterior longitudinal ligament (OPLL) has increased in older adults, its etiology and neurological outcomes remain unknown. We identified OPLL characteristics and determined whether they influence neurological severity and improvement of CSCI in older patients. This multicenter retrospective cohort study identified 1512 patients aged ≥ 65 years diagnosed with CSCI on admission during 2010–2020. We analyzed CSCI etiology in OPLL patients. We performed propensity score-adjusted analyses to compare neurological outcomes between patients with and without OPLL. Cases were matched based on variables influencing neurological prognosis. The primary neurological outcome was rated according to the American Spine Injury Association (ASIA) impairment scale (AIS) and ASIA motor score (AMS). In 332 OPLL patients, the male-to-female ratio was approximately 4:1. Half of all patients displayed low-energy trauma-induced injury and one-third had CSCI without a bony injury. Propensity score matching created 279 pairs. There was no significant difference in the AIS grade and AMS between patients with and without OPLL during hospitalization, 6 months, and 12 months following injury. OPLL patients tended to exhibit worse neurological findings during injury; nevertheless, OPLL was not associated with poor neurological improvement in older CSCI patients.

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  58. Biopsy-proven CKD etiology and outcomes: the Chronic Kidney Disease Japan Cohort (CKD-JAC) study

    Hamano, T; Imaizumi, T; Hasegawa, T; Fujii, N; Komaba, H; Ando, M; Nangaku, M; Nitta, K; Hirakata, H; Isaka, Y; Wada, T; Maruyama, S; Fukagawa, M

    NEPHROLOGY DIALYSIS TRANSPLANTATION   Vol. 38 ( 2 ) page： 384 - 395   2023.2

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    Background: The Kidney Disease: Improving Global Outcomes guidelines advocate the cause-glomerular filtration rate (GFR)-albuminuria (CGA) classification for predicting outcomes. However, there is a dearth of data supporting the use of the cause of chronic kidney disease. This study aimed to address how to incorporate a prior biopsy-proven diagnosis in outcome prediction. Methods: We examined the association of biopsy-proven kidney disease diagnoses with kidney failure with replacement therapy (KFRT) and all-cause death before KFRT in patients with various biopsy-proven diagnoses (n = 778, analysis A) and patients with diabetes mellitus labeled with biopsy-proven diabetic nephropathy (DN), other biopsy-proven diseases and no biopsy (n = 1117, analysis B). Results: In analysis A, adding biopsy-proven diagnoses to the GFR-albuminuria (GA) classification improved the prediction of 8-year incidence of KFRT and all-cause death significantly regarding integrated discrimination improvement and net reclassification index. Fine-Gray (FG) models with KFRT as a competing event showed significantly higher subdistribution hazard ratios (SHRs) for all-cause death in nephrosclerosis {4.12 [95% confidence interval (CI) 1.11-15.2)], focal segmental glomerulosclerosis [3.77 (95% CI 1.09-13.1)]} and membranous nephropathy (MN) [2.91 (95% CI 1.02-8.30)] than in immunoglobulin A nephropathy (IgAN), while the Cox model failed to show significant associations. Crescentic glomerulonephritis had the highest risk of all-cause death [SHR 5.90 (95% CI 2.05-17.0)]. MN had a significantly lower risk of KFRT than IgAN [SHR 0.45 (95% CI 0.24-0.84)]. In analysis B, other biopsy-proven diseases had a lower risk of KFRT than biopsy-proven DN in the FG model, with death as a competing event [SHR 0.62 (95% CI 0.39-0.97)]. Conclusions: The CGA classification is of greater value in predicting outcomes than the GA classification.

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  59. JCMT BISTRO Observations: Magnetic Field Morphology of Bubbles Associated with NGC 6334

    Tahani, M; Bastien, P; Furuya, RS; Pattle, K; Johnstone, D; Arzoumanian, D; Doi, Y; Hasegawa, T; Inutsuka, S; Coudé, S; Fissel, L; Chen, MCY; Poidevin, F; Sadavoy, S; Friesen, R; Koch, PM; Di Francesco, J; Moriarty-Schieven, GH; Chen, ZW; Chung, EJ; Eswaraiah, C; Fanciullo, L; Gledhill, T; Le Gouellec, VJM; Hoang, T; Hwang, J; Kang, JH; Kim, KH; Kirchschlager, F; Kwon, W; Lee, CW; Liu, HL; Onaka, T; Rawlings, MG; Soam, A; Tamura, M; Tang, XD; Tomisaka, K; Whitworth, AP; Kwon, J; Hoang, TD; Redman, M; Berry, D; Ching, TC; Wang, JW; Lai, SP; Qiu, KP; Ward-Thompson, D; Houde, M; Byun, D; Chen, HRV; Chen, WP; Cho, JY; Choi, M; Choi, Y; Chrysostomou, A; Diep, PN; Duan, HY; Fiege, J; Franzmann, E; Friberg, P; Fuller, G; Graves, SF; Greaves, JS; Griffin, MJ; Gu, QL; Han, IL; Hatchell, J; Hayashi, SS; Hull, CLH; Inoue, T; Iwasaki, K; Jeong, I; Kanamori, Y; Kang, MJ; Kang, SJ; Kataoka, A; Kawabata, KS; Kemper, F; Kim, G; Kim, J; Kim, KT; Kim, MR; Kim, S; Kirk, JM; Kobayashi, MIN; Konyves, V; Kusune, T; Lacaille, K; Law, CY; Lee, CF; Lee, HYS; Lee, JE; Lee, SS; Lee, YH; Li, DL; Li, D; Li, HB; Liu, JH; Liu, SY; Liu, T; de Looze, I; Lyo, AR; Mairs, S; Matsumura, M; Matthews, BC; Nagata, T; Nakamura, F; Nakanishi, H; Ohashi, N; Park, G; Parsons, H; Peretto, N; Pyo, TS; Qian, L; Rao, RMS; Retter, B; Richer, J; Rigby, A; Saito, H; Savini, G; Scaife, AMM; Seta, M; Shimajiri, Y; Shinnaga, H; Tang, YW; Tsukamoto, Y; Viti, S; Wang, HC; Yen, HW; Yoo, H; Yuan, JH; Yun, HS; Zenko, T; Zhang, CP; Zhang, GY; Zhang, YP; Zhou, JJ; Zhu, L; André, P; Dowell, CD; Eyres, SPS; Falle, S; van Loo, S; Robitaille, JF

    ASTROPHYSICAL JOURNAL   Vol. 944 ( 2 )   2023.2

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    We study the Hii regions associated with the NGC 6334 molecular cloud observed in the submillimeter and taken as part of the B-fields In STar-forming Region Observations Survey. In particular, we investigate the polarization patterns and magnetic field morphologies associated with these Hii regions. Through polarization pattern and pressure calculation analyses, several of these bubbles indicate that the gas and magnetic field lines have been pushed away from the bubble, toward an almost tangential (to the bubble) magnetic field morphology. In the densest part of NGC 6334, where the magnetic field morphology is similar to an hourglass, the polarization observations do not exhibit observable impact from Hii regions. We detect two nested radial polarization patterns in a bubble to the south of NGC 6334 that correspond to the previously observed bipolar structure in this bubble. Finally, using the results of this study, we present steps (incorporating computer vision; circular Hough transform) that can be used in future studies to identify bubbles that have physically impacted magnetic field lines.

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  60. Successive phase transitions of the spin-orbit-coupled metal Cd<sub>2</sub>Re<sub>2</sub>O<sub>7</sub> probed by high-resolution synchrotron x-ray diffraction

    Hirai, D; Fukui, A; Sagayama, H; Hasegawa, T; Hiroi, Z

    JOURNAL OF PHYSICS-CONDENSED MATTER   Vol. 35 ( 3 )   2023.1

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    The 5d pyrochlore oxide superconductor Cd2Re2O7 (CRO) has attracted significant interest as a spin-orbit-coupled metal (SOCM) that spontaneously undergoes a phase transition to an odd-parity multipole phase by breaking the spatial inversion symmetry due to the Fermi liquid instability caused by strong spin-orbit coupling. Despite the significance of structural information during the transition, previous experimental results regarding lattice deformation have been elusive. We have conducted ultra-high resolution synchrotron radiation x-ray diffraction experiments on a high-quality CRO single crystal. The temperature-dependent splitting of the 0 0 16 and 0 0 14 reflections, which are allowed and forbidden, respectively, in the high-temperature cubic phase I (space group Fd-3m), has been clearly observed and reveals the following significant facts: inversion symmetry breaking and tetragonal distortion occur simultaneously at T s1 = 201.5(1) K; the previously believed first-order transition between phase II (I-4m2) and phase III (I4122) at T s2 ∼120 K consists of two close second-order transitions at T s2 = 115.4(1) K and T s3 ∼ 100 K; there is a new orthorhombic phase XI (F222) in between. The order parameters (OPs) of these continuous transitions are uniquely represented by a two-dimensional irreducible representation Eu of the Oh point group, and the OPs of phase XI are a linear combination of those of phases II and III. Each phase is believed to correspond to a distinct odd-parity multipole order, and the complex successive transitions observed may be the result of an electronic phase transition that resolves the Fermi liquid instability in the SOCM.

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  61. Search for Cosmic-Ray Boosted Sub-GeV Dark Matter Using Recoil Protons at Super-Kamiokande

    Abe, K; Hayato, Y; Hiraide, K; Ieki, K; Ikeda, M; Kameda, J; Kanemura, Y; Kaneshima, R; Kashiwagi, Y; Kataoka, Y; Miki, S; Mine, S; Miura, M; Moriyama, S; Nakano, Y; Nakahata, M; Nakayama, S; Noguchi, Y; Okamoto, K; Sato, K; Sekiya, H; Shiba, H; Shimizu, K; Shiozawa, M; Sonoda, Y; Suzuki, Y; Takeda, A; Takemoto, Y; Takenaka, A; Tanaka, H; Watanabe, S; Yano, T; Han, S; Kajita, T; Okumura, K; Tashiro, T; Tomiya, T; Wang, X; Xia, J; Yoshida, S; Megias, GD; Fernandez, P; Labarga, L; Ospina, N; Zaldivar, B; Pointon, BW; Kearns, E; Raaf, JL; Wan, L; Wester, T; Bian, J; Griskevich, NJ; Kropp, WR; Locke, S; Smy, MB; Sobel, HW; Takhistov, V; Yankelevich, A; Hill, J; Park, RG; Bodur, B; Scholberg, K; Walter, CW; Bernard, L; Coffani, A; Drapier, O; El Hedri, S; Giampaolo, A; Mueller, TA; Santos, AD; Paganini, P; Quilain, B; Ishizuka, T; Nakamura, T; Jang, JS; Learned, JG; Choi, K; Cao, S; Anthony, LHV; Martin, D; Scott, M; Sztuc, AA; Uchida, Y; Berardi, V; Catanesi, MG; Radicioni, E; Calabria, NF; Machado, LN; De Rosa, G; Collazuol, G; Iacob, F; Lamoureux, M; Mattiazzi, M; Ludovici, L; Gonin, M; Pronost, G; Fujisawa, C; Maekawa, Y; Nishimura, Y; Friend, M; Hasegawa, T; Ishida, T; Kobayashi, T; Jakkapu, M; Matsubara, T; Nakadaira, T; Nakamura, K; Oyama, Y; Sakashita, K; Sekiguchi, T; Tsukamoto, T; Boschi, T; Di Lodovico, F; Gao, J; Goldsack, A; Katori, T; Migenda, J; Taani, M; Zsoldos, S; Kotsar, Y; Ozaki, H; Suzuki, AT; Takeuchi, Y; Bronner, C; Feng, J; Kikawa, T; Mori, M; Nakaya, T; Wendell, RA; Yasutome, K; Jenkins, SJ; McCauley, N; Mehta, P; Tsui, KM; Fukuda, Y; Itow, Y; Menjo, H; Ninomiya, K; Lagoda, J; Lakshmi, SM; Mandal, M; Mijakowski, P; Prabhu, YS; Zalipska, J; Jia, M; Jiang, J; Jung, CK; Wilking, MJ; Yanagisawa, C; Harada, M; Ishino, H; Ito, S; Kitagawa, H; Koshio, Y; Nakanishi, F; Sakai, S; Barr, G; Barrow, D; Cook, L; Samani, S; Wark, D; Nova, F; Yang, JY; Malek, M; McElwee, JM; Stone, O; Thiesse, MD; Thompson, LF; Okazawa, H; Kim, SB; Seo, JW; Yu, I; Ichikawa, AK; Nakamura, KD; Tairafune, S; Nishijima, K; Iwamoto, K; Nakagiri, K; Nakajima, Y; Taniuchi, N; Yokoyama, M; Martens, K; de Perio, P; Vagins, MR; Kuze, M; Izumiyama, S; Inomoto, M; Ishitsuka, M; Ito, H; Kinoshita, T; Matsumoto, R; Ommura, Y; Shigeta, N; Shinoki, M; Suganuma, T; Yamauchi, K; Martin, JF; Tanaka, HA; Towstego, T; Akutsu, R; Gousy-Leblanc, V; Hartz, M; Konaka, A; Prouse, NW; Chen, S; Xu, BD; Zhang, B; Posiadala-Zezula, M; Hadley, D; Nicholson, M; O'Flaherty, M; Richards, B; Ali, A; Jamieson, B; Marti, L; Minamino, A; Pintaudi, G; Sano, S; Suzuki, S; Wada, K

    PHYSICAL REVIEW LETTERS   Vol. 130 ( 3 ) page： 031802   2023.1

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    We report a search for cosmic-ray boosted dark matter with protons using the 0.37 megaton×years data collected at Super-Kamiokande experiment during the 1996-2018 period (SKI-IV phase). We searched for an excess of proton recoils above the atmospheric neutrino background from the vicinity of the Galactic Center. No such excess is observed, and limits are calculated for two reference models of dark matter with either a constant interaction cross section or through a scalar mediator. This is the first experimental search for boosted dark matter with hadrons using directional information. The results present the most stringent limits on cosmic-ray boosted dark matter and exclude the dark matter-nucleon elastic scattering cross section between 10-33cm2 and 10-27cm2 for dark matter mass from 1 MeV/c2 to 300 MeV/c2.

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  62. Epidemiology of Cervical Fracture/Cervical Spinal Cord Injury and Changes in Surgical Treatment Modalities in Elderly Individuals During a 10-year Period: A Nationwide Multicenter Study in Japan

    Segi, N; Nakashima, H; Machino, M; Ito, S; Yokogawa, N; Sasagawa, T; Funayama, T; Eto, F; Watanabe, K; Nori, S; Furuya, T; Yunde, A; Nakajima, H; Hasegawa, T; Yamada, T; Terashima, Y; Hirota, R; Suzuki, H; Imajo, Y; Ikegami, S; Uehara, M; Tonomura, H; Sakata, M; Hashimoto, K; Onoda, Y; Kawaguchi, K; Haruta, Y; Suzuki, N; Kato, K; Uei, H; Sawada, H; Nakanishi, K; Misaki, K; Terai, H; Tamai, K; Inoue, G; Shirasawa, E; Kakutani, K; Iizuka, Y; Takasawa, E; Akeda, K; Kiyasu, K; Tominaga, H; Tokumoto, H; Funao, H; Oshima, Y; Yoshii, T; Kaito, T; Sakai, D; Ohba, T; Seki, S; Otsuki, B; Ishihara, M; Miyazaki, M; Okada, S; Imagama, S; Kato, S

    GLOBAL SPINE JOURNAL     page： 21925682231151643   2023.1

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    Study Design: Retrospective multicenter study Objectives: To investigate changes over a 10-years period in the profile of cervical spine and spinal cord injuries among the elderly in Japan. Methods: The current multicenter study was a retrospective analysis of inpatients aged ≥65 years, suffering cervical fracture (CF) and/or cervical spinal cord injury (CSCI). We analyzed 1413 patients’ epidemiology (from 2010 to 2019). Moreover, 727 patients who underwent surgical treatment were analyzed in 2 groups: the early (2010-2014) and late period (2015-2019). Results: Both the number of patients and number of surgical patients showed a significant increasing trend (P <.001), while the mean age, the distribution of injury levels and paralysis severity, and the proportion of surgical indications remained the same. The number of surgical patients doubled from 228 to 499 from the early to late periods. Posterior surgery was the most common approach (90.4%), instrumentation surgery with screws increased significantly, and the range of fusion was significantly longer in the late period (2.1 vs 2.7 levels, P =.001). Significantly worsening neurological symptoms were recorded in the late period (1.3% vs 5.8%, P =.006), with C5 palsy being the major one. Otherwise, perioperative, major, and other complications, including mortality, did not differ significantly in incidence. Conclusions: Both the number of elderly CF and/or CSCI patients and number of patients undergoing surgery increased dramatically over the decade without any change in profile. Instrumentation surgeries with screws increased, without an increase in systemic complications.

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  63. Effects of work–family life support program on the work–family interface and mental health among Japanese dual-earner couples with a preschool child: A randomized controlled trial

    Shimazu A., Fujiwara T., Iwata N., Kato Y., Kawakami N., Maegawa N., Nakao M., Nomiyama T., Takahashi M., Tayama J., Watai I., Arima M., Hasegawa T., Matsudaira K., Matsuyama Y., Miyazawa Y., Shimada K., Takahashi M., Watanabe M., Yamaguchi A., Adachi M., Tomida M., Chen D., Doi S., Hirano S., Isokawa S., Kamijo T., Kobayashi T., Matsuzaki K., Moridaira N., Nitto Y., Ogawa S., Sakurai M., Sasaki N., Tobayama M., Yamauchi K., Obikane E., Odawara M., Sakka M., Takeuchi K., Tokita M.

    Journal of Occupational Health   Vol. 65 ( 1 )   2023.1

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    Objectives: This study examined the effectiveness of a newly developed work–family life support program on the work–family interface and mental health indicators among Japanese dual-earner couples with a preschool child(/ren) using a randomized controlled trial with a waitlist. Methods: Participants who met the inclusion criteria were randomly allocated to the intervention or the control groups (n = 79 and n = 85, respectively). The program comprised two 3-h sessions with a 1-month interval between them and provided comprehensive skills by including self-management, couple management, and parenting management components. The program sessions were conducted on weekends in a community center room with 3–10 participants. Outcomes were assessed at baseline, 1-month, and 3-month follow-ups. Primary outcomes were work–family balance self-efficacy (WFBSE), four types of work–family spillovers (i.e., work-to-family conflict, family-to-work conflict, work-to-family facilitation, and family-to-work facilitation), psychological distress, and work engagement reported by the participants. Results: The program had significantly pooled intervention effects on WFBSE (P =.031) and psychological distress (P =.014). The effect sizes (Cohen's d) were small, with values of 0.22 at the 1-month follow-up and 0.24 at the 3-month follow-up for WFBSE, and −0.36 at the 3-month follow-up for psychological distress. However, the program had nonsignificant pooled effects on four types of work–family spillovers and work engagement. Conclusions: The program effectively increased WFBSE and decreased psychological distress among Japanese dual-earner couples with a preschool child(/ren).

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  64. Risk Factors for Early Mortality in Older Patients with Traumatic Cervical Spine Injuries-A Multicenter Retrospective Study of 1512 Cases

    Kobayashi, M; Yokogawa, N; Kato, S; Sasagawa, T; Tsuchiya, H; Nakashima, H; Segi, N; Ito, S; Funayama, T; Eto, F; Yamaji, A; Yamane, J; Nori, S; Furuya, T; Yunde, A; Nakajima, H; Yamada, T; Hasegawa, T; Terashima, Y; Hirota, R; Suzuki, H; Imajo, Y; Ikegami, S; Uehara, M; Tonomura, H; Sakata, M; Hashimoto, K; Onoda, Y; Kawaguchi, K; Haruta, Y; Suzuki, N; Kato, K; Uei, H; Sawada, H; Nakanishi, K; Misaki, K; Terai, H; Tamai, K; Kuroda, A; Inoue, G; Kakutani, K; Kakiuchi, Y; Kiyasu, K; Tominaga, H; Tokumoto, H; Iizuka, Y; Takasawa, E; Akeda, K; Takegami, N; Funao, H; Oshima, Y; Kaito, T; Sakai, D; Yoshii, T; Ohba, T; Otsuki, B; Seki, S; Miyazaki, M; Ishihara, M; Okada, S; Imagama, S; Watanabe, K

    JOURNAL OF CLINICAL MEDICINE   Vol. 12 ( 2 )   2023.1

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    For older patients with decreased reserve function, traumatic cervical spine injuries frequently lead to early mortality. However, the prognostic factors for early mortality remain unclear. This study included patients aged ≥65 years and hospitalized for treatment of traumatic cervical spine injuries in 78 hospitals between 2010 and 2020. Early mortality was defined as death within 90 days after injury. We evaluated the relationship between early mortality and the following factors: age, sex, body mass index, history of drinking and smoking, injury mechanisms, presence of a cervical spine fracture and dislocation, cervical ossification of the posterior longitudinal ligament, diffuse idiopathic skeletal hyperostosis, American Spinal Injury Association Impairment Scale, concomitant injury, pre-existing comorbidities, steroid administration, and treatment plan. Overall, 1512 patients (mean age, 75.8 ± 6.9 years) were included in the study. The early mortality rate was 4.0%. Multivariate analysis identified older age (OR = 1.1, p < 0.001), male sex (OR = 3.7, p = 0.009), cervical spine fracture (OR = 4.2, p < 0.001), complete motor paralysis (OR = 8.4, p < 0.001), and chronic kidney disease (OR = 5.3, p < 0.001) as risk factors for early mortality. Older age, male sex, cervical spine fracture, complete motor paralysis, and chronic kidney disease are prognostic factors for early mortality in older patients with traumatic cervical spine injuries.

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  65. Impact of the Ablative Margin on Local Tumor Progression after Radiofrequency Ablation for Lung Metastases from Colorectal Carcinoma: Supplementary Analysis of a Phase II Trial

    Hasegawa, T; Takaki, H; Kodama, H; Matsuo, K; Yamanaka, T; Nakatsuka, A; Takao, M; Gobara, H; Hayashi, S; Inaba, Y; Yamakado, K

    JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY   Vol. 34 ( 1 ) page： 31 - +   2023.1

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    Purpose: To explore what extent of ablative margin depicted by computed tomography (CT) immediately after radiofrequency (RF) ablation is required to reduce local tumor progression (LTP) for colorectal cancer (CRC) lung metastases. Materials and Methods: This retrospective study was undertaken as a supplementary analysis of a previous prospective trial. Seventy patients (49 men and 21 women; mean age ± standard deviation, 64.9 years ± 10.6 years) underwent RF ablation for CRC lung metastases, and 95 tumors that were treated in the trial and followed up with CT at least 12 months after RF ablation were evaluated. The mean tumor size was 1.0 cm ± 0.5 cm. The ablative margin was estimated as the shortest distance between the outer edge of the tumor and the surrounding ground-glass opacity on CT obtained immediately after RF ablation. The impact of the ablative margin on LTP was evaluated using logistic regression analysis. Multivariate logistic regression analysis was also performed to identify the risk factors for LTP. The result was validated with multivariate logistic regression applying a bootstrap method (1,000 times resampling). Results: The mean ablative margin was 2.7 mm ± 1.3 (range, 0.4–7.3 mm). LTP developed in 6 tumors (6%, 6/95) 6–19 months after RF ablation. The LTP rate was significantly higher when the margin was less than 2 mm (P = .023). A margin of <2 mm was also found to be a significant factor for LTP (P = .048) on multivariate analysis and validated using the bootstrap method (P = .025). Conclusions: An ablative margin of at least 2 mm is important to reduce LTP after RF ablation for CRC lung metastases.

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  66. Nationwide Survey of the Surgical Complications Associated with Lateral Lumbar Interbody Fusion in 2015-2020

    Yagi, M; Fujita, N; Hasegawa, T; Inoue, G; Kotani, Y; Ohtori, S; Orita, S; Oshima, Y; Sakai, D; Sakai, T; Taneichi, H; Togawa, D; Nakanishi, K; Nakashima, H; Yoshii, T; Nakamura, M; Iwasaki, M; Watanabe, M; Haro, H; Kanemura, T; Hosogane, N

    SPINE SURGERY AND RELATED RESEARCH   Vol. 7 ( 3 ) page： 249 - 256   2023

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    Language：English   Publisher：Spine Surgery and Related Research  

    Introduction: Lateral lumbar interbody fusion (LLIF) has been introduced in Japan in 2013. Despite the effectiveness of this procedure, several considerable complications have been reported. This study reported the results of a nationwide survey performed by the Japanese Society for Spine Surgery and Related Research (JSSR) on the complications associated with LLIF performed in Japan. Methods: JSSR members conducted a web-based survey following LLIF between 2015 and 2020. Any complications meeting the following criteria were included: (1) major vessel, (2) urinary tract, (3) renal, (4) visceral organ, (5) lung, (6) vertebral, (7) nerve, and (8) anterior longitudinal ligament injury; (9) weakness of psoas; (10) motor and (11) sensory deficit; (12) surgical site infection; and (13) other complications. The complications were analyzed in all LLIF patients, and the differences in incidence and type of complications between the transpsoas (TP) and prepsoas (PP) approaches were compared. Results: Among the 13,245 LLIF patients (TP 6,198 patients [47%] and PP 7,047 patients [53%]), 389 complications occurred in 366 (2.76%) patients. The most common complication was sensory deficit (0.5%), followed by motor deficit (0.43%) and weakness of psoas muscle (0.22%). Among the patient cohort, 100 patients (0.74%) required revision surgery during the survey period. Almost half of the complications developed in patients with spinal deformity (183 patients [47.0%]). Four patients (0.03%) died from complications. Statistically more frequent complications occurred in the TP approach than in the PP approach (TP vs. PP, 220 patients [3.55%] vs. 169 patients [2.40%]; p<0.001). Conclusions: The overall complication rate was 2.76%, and 0.74% of the patients required revision surgery because of complications. Four patients died from complications. LLIF may be beneficial for degenerative lumbar conditions with acceptable complications; however, the indication for spinal deformity should be carefully determined by the experience of the surgeon and the extent of the deformity.

    DOI： 10.22603/ssrr.2022-0194

    Web of Science

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    PubMed

  67. Worsening ambulation in elderly patients with cervical odontoid fractures: A nationwide multicenter study in Japan

    Segi N., Nakashima H., Ito S., Yokogawa N., Ikegami S., Watanabe K., Funayama T., Hasegawa T., Tonomura H., Kakutani K., Furuya T., Suzuki N., Kiyasu K., Tominaga H., Miyazaki M., Terashima Y., Suzuki H., Hashimoto K., Uei H., Funao H., Kaito T., Kawaguchi K., Sakai D., Seki S., Otsuki B., Inoue G., Okada S., Imagama S., Kato S.

    Journal of Orthopaedic Science     2023

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    Language：English   Publisher：Journal of Orthopaedic Science  

    Background: Despite the increasing prevalence of cervical odontoid fractures in older adults, the treatment strategy is controversial. The objectives of the current study are to investigate the prognosis and complications of cervical odontoid fractures in elderly patients and to identify factors associated with worsening of ambulation after 6 months. Methods: This multicenter, retrospective study included 167 patients aged 65 years or older with odontoid fractures. Patient demographic and treatment data were investigated and compared according to the treatment strategy. To determine associations with worsening ambulation after 6 months, we focused on the treatment strategies (nonsurgical treatment [collar immobilization or halo vest], conversion to surgery, or initial surgery) and patients’ background. Results: Patients who received nonsurgical treatment were significantly older, and patients who underwent surgery had more Anderson-D'Alonzo type 2 fractures. Of the patients initially treated nonsurgically, 26% later underwent surgery. Numbers of complications, including death, and degrees of ambulation after 6 months did not differ significantly among treatment strategies. Patients who had worsened ambulation after 6 months were significantly more likely to be older than 80 years, to have needed assistance with walking before injury, and to have cerebrovascular disease. Multivariable analysis showed that a score of ≥2 on the 5-item modified frailty index (mFI-5) was significantly associated with worsening ambulation. Conclusions: Preinjury mFI-5 scores of ≥2 were significantly associated with worsening ambulation 6 months after treatment of cervical odontoid fractures in older adults.

    DOI： 10.1016/j.jos.2023.05.006

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