Organization
Nagoya University Hospital Dermatology Assistant Professor
Graduate School
Graduate School of Medicine
Title
Assistant Professor
MOMOHARA Mariko
Papers 41
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Increased Janus kinase activation in cutaneous vasculitis.
Ebata A, Ogawa-Momohara M, Fukaura R, Yamashita Y, Koizumi H, Takeichi T, Muro Y, Akiyama M
Journal of the American Academy of Dermatology Vol. 90 ( 3 ) page： 627 - 629 2024.3
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Correlation of serum allergen-specific IgE with total serum IgE and IgE specific to other allergens in Atopic dermatitis patients.
Akashi N, Ogawa-Momohara M, Taki T, Fukaura R, Wakahara K, Kamiya S, Yamashita Y, Koizumi H, Takeichi T, Muro Y, Akiyama M
Journal of the European Academy of Dermatology and Venereology : JEADV 2024.2
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Panniculitis on the trunk as a possible characteristic feature of anti-SAE1/2 antibody-positive dermatomyositis: A possible cutaneous manifestation of treatment resistance.
Tago M, Koizumi H, Kamiya S, Akashi N, Miyazaki A, Yamashita Y, Ogawa-Momohara M, Takeichi T, Muro Y, Akiyama M
The Journal of dermatology 2024.2
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ELISA detection of anti-eIF2B antibodies in Japanese patients with systemic sclerosis.
Koizumi H, Yamano Y, Muro Y, Fukaura R, Yamashita Y, Kamiya S, Akashi N, Ogawa-Momohara M, Takeichi T, Kondoh Y, Akiyama M
Rheumatology (Oxford, England) 2023.12
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症例報告 特発性細菌性腹膜炎を合併した急性膵炎後の皮下結節性脂肪壊死症の1例
天野 友里恵, 桃原 真理子, 竹内 想, 河野 通浩, 秋山 真志, 倉田 信彦, 植月 康太
臨床皮膚科 Vol. 77 ( 11 ) page： 921 - 925 2023.10
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Allergen-specific IgG4 increase in atopic dermatitis with long-term dupilumab use.
Ogawa-Momohara M, Muro Y, Murase C, Taki T, Tanahashi K, Yamashita Y, Koizumi H, Fukaura R, Takeichi T, Akiyama M
The British journal of dermatology Vol. 189 ( 4 ) page： 472 - 474 2023.9
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Comment on: Successful treatment of rapid progressive interstitial lung disease in a case of anti-Zo antibody positive anti-synthetase syndrome.
Koizumi H, Muro Y, Kamiya S, Akashi N, Imai S, Yamashita Y, Ogawa-Momohara M, Takeichi T, Akiyama M
International journal of rheumatic diseases Vol. 26 ( 9 ) page： 1872 - 1873 2023.9
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Cutaneous manifestations of microscopic polyangiitis successfully controlled with avacopan alone.
Kamiya S, Koizumi H, Suzuki Y, Imai S, Yamashita Y, Ogawa-Momohara M, Takeichi T, Muro Y, Yasuda K, Akiyama M
The Journal of dermatology Vol. 50 ( 7 ) page： e206 - e207 2023.7
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Successful combination therapy of bimekizumab and granulocyte monocyte adsorption apheresis for generalized pustular psoriasis complicated with microscopic polyangiitis.
Shukuin R, Koizumi H, Ebata A, Imai S, Yamashita Y, Ogawa-Momohara M, Takeichi T, Muro Y, Takami N, Akiyama M
The Journal of dermatology Vol. 50 ( 6 ) page： e181 - e182 2023.6
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Comment on: Disease evolution in a long-term follow-up of 104 undifferentiated connective tissue disease patients.
Yamashita Y, Muro Y, Koizumi H, Ogawa-Momohara M, Takeichi T, Akiyama M
Clinical and experimental rheumatology Vol. 41 ( 1 ) page： 195 - 196 2023.1
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Koizumi H, Muro Y, Imai S, Yamashita Y, Ogawa-Momohara M, Takeichi T, Murakami M, Mitsuma T, Akiyama M
The Journal of dermatology Vol. 50 ( 1 ) page： e39 - e40 2023.1
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Appropriate immunoassay systems are needed to evaluate various anticentromere antibodies as biomarkers for disease progression in systemic sclerosis.
Muro Y, Yamashita Y, Koizumi H, Ogawa-Momohara M, Takeichi T, Akiyama M
Journal of immunological methods Vol. 512 page： 113400 2023.1
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Two novel anti-aminoacyl tRNA synthetase antibodies: Autoantibodies against cysteinyl-tRNA synthetase and valyl-tRNA synthetase.
Muro Y, Yamashita Y, Koizumi H, Ogawa-Momohara M, Takeichi T, Mitsuma T, Akiyama M
Autoimmunity reviews Vol. 21 ( 12 ) page： 103204 2022.12
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Clinical significance of anti-NOR90 antibodies in systemic sclerosis and idiopathic interstitial pneumonia.
Yamashita Y, Yamano Y, Muro Y, Ogawa-Momohara M, Takeichi T, Kondoh Y, Akiyama M
Rheumatology (Oxford, England) Vol. 61 ( 4 ) page： 1709 - 1716 2022.4
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Anti-Zo antibodies in Japanese myositis patients detected by a newly developed ELISA.
Muro Y, Hashimoto T, Izumi S, Ogawa-Momohara M, Takeichi T, Yamashita H, Yasuoka H, Akiyama M
Clinical and experimental rheumatology Vol. 40 ( 2 ) page： 219 - 223 2022.2
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Response to: 'Anti-Ku antibodies: important points to consider' by Mahler et al.
Ogawa-Momohara M, Muro Y, Akiyama M
Annals of the rheumatic diseases Vol. 80 ( 11 ) page： e183 2021.11
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Overlap of systemic lupus erythematosus and myositis is rare in anti-Ku antibody-positive patients
Ogawa-Momohara M.
Annals of the Rheumatic Diseases Vol. 80 ( 9 ) page： e147 2021.9
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Immune recognition of lysyl-tRNA synthetase and isoleucyl-tRNA synthetase by anti-OJ antibody-positive sera.
Muro Y, Yamano Y, Yoshida K, Oto Y, Nakajima K, Mitsuma T, Kikuchi S, Matsumae A, Ogawa-Momohara M, Takeichi T, Kondoh Y, Katayama M, Todoroki Y, Tanaka Y, Satoh M, Akiyama M
Journal of autoimmunity Vol. 122 page： 102680 2021.8
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Autoantibody profiles in patients' sera associated with distribution patterns of dermatomyositis skin symptoms.
Ogawa-Momohara M, Kinoshita F, Muro Y, Kobayashi Y, Takeichi T, Akiyama M
Journal of the American Academy of Dermatology Vol. 84 ( 6 ) page： 1720 - 1722 2021.6
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ANCA‐associated neuropathy in systemic sclerosis: A case report and review of literature
Kayo Takenaka, Takuya Takeichi, Ryoji Nishi, Masashi Suzuki, Haruki Koike, Masahisa Katsuno, Mariko Ogawa‐Momohara, Yoshinao Muro, Masashi Akiyama
Journal of Cutaneous Immunology and Allergy Vol. 4 ( 2 ) page： 34 - 36 2021.2
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Morphea in a Crohn's disease patient undergoing ustekinumab treatment.
Makihara-Inukai M, Takeichi T, Ogawa-Momohara M, Muro Y, Akiyama M
European journal of dermatology : EJD Vol. 31 ( 1 ) page： 96 - 97 2021.2
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A case with overlapping features of IgG4-related autoimmune pancreatitis, Sjögren's syndrome and anti-aminoacyl-tRNA synthetase syndrome.
Yoshikawa M, Muro Y, Ogawa-Momohara M, Ito S, Takeichi T, Akiyama M
Modern rheumatology case reports Vol. 5 ( 1 ) page： 82 - 86 2021.1
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Tanaka Y.
Modern Rheumatology Vol. 31 ( 1 ) page： 29 - 33 2021.1
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A case of systemic lupus erythematosus/systemic sclerosis overlap syndrome successfully treated with belimumab.
Hara M, Ogawa-Momohara M, Muro Y, Takeichi T, Akiyama M
European journal of dermatology : EJD Vol. 30 ( 5 ) page： 615 - 617 2020.10
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Clinical and serological features of dermatomyositis and systemic lupus erythematosus patients with autoantibodies to ADAR1.
Muro Y, Ogawa-Momohara M, Takeichi T, Fukaya S, Yasuoka H, Kono M, Akiyama M
Journal of dermatological science Vol. 100 ( 1 ) page： 82 - 84 2020.10
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Okochi S.
Clinical and Experimental Dermatology Vol. 45 ( 5 ) page： 591-593 2020.7
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Subacute cutaneous lupus erythematosus with melanocyte elimination induced by pembrolizumab
Ogawa-Momohara M.
Journal of Dermatology Vol. 47 ( 6 ) page： e217 - e219 2020.6
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sQUIZ your knowledge: Multiple subcutaneous nodules symmetrically located on tendinous regions
Hokari N.
European journal of dermatology : EJD Vol. 30 ( 2 ) page： 226 - 227 2020.4
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Remodelling of calcinosis cutis in a patient with scleroderma overlap syndrome
Dittmer M.R.
Journal of the European Academy of Dermatology and Venereology Vol. 34 ( 1 ) page： e20-e21 2020.1
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Clinical characteristics of anti-Ro52α and anti-Ro52β antibodies in dermatomyositis/polymyositis.
Ogawa-Momohara M, Muro Y, Mitsuma T, Katayama M, Yanaba K, Nara M, Kakeda M, Akiyama M
Journal of dermatological science Vol. 96 ( 1 ) page： 50 - 52 2019.10
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Ogawa-Momohara M.
British Journal of Dermatology Vol. 180 ( 4 ) page： 941-942 2019.4
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Anti‐Mi‐2 antibody titers and cutaneous manifestations in dermatomyositis
Mariko Ogawa‐Momohara, Yoshinao Muro, Masashi Akiyama
Journal of Cutaneous Immunology and Allergy Vol. 2 ( 2 ) page： 49 - 52 2019.2
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Prognosis of dysphagia in dermatomyositis.
Ogawa-Momohara M, Muro Y, Kono M, Akiyama M
Clinical and experimental rheumatology Vol. 37 ( 1 ) page： 165 2019.1
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Prognosis of dysphagia in dermatomyositis
Ogawa-Momohara M.
Clinical and Experimental Rheumatology Vol. 37 ( 1 ) page： . 2019
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Vol. 36 ( 6 ) page： 990-995 2018.11
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Strong correlation between cancer progression and anti-transcription intermediary factor 1γ antibodies in dermatomyositis patients.
Ogawa-Momohara M, Muro Y, Mitsuma T, Katayama M, Yanaba K, Nara M, Kakeda M, Kono M, Akiyama M
Clinical and experimental rheumatology Vol. 36 ( 6 ) page： 990 - 995 2018.11
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Kochi Y.
Annals of the Rheumatic Diseases Vol. 77 ( 4 ) page： 602 - 611 2018.4
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Fujita-Tanaka H.
British Journal of Dermatology Vol. 178 ( 3 ) page： e210-e211 2018.3
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Autoantibodies to Su/Argonaute 2 in Japanese patients with inflammatory myopathy
Ogawa-Momohara M.
Clinica Chimica Acta Vol. 471 page： 304 - 307 2017.8
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Ortner's syndrome caused by pulmonary arterial hypertension associated with mixed connective tissue disease.
Ogawa-Momohara M, Muro Y, Hirashiki A, Fujimoto Y, Kondo T, Akiyama M
Clinical and experimental rheumatology Vol. 34 ( 6 ) page： 1125 2016.11
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Successful topical adapalene treatment for the facial lesions of an adolescent case of epidermolytic ichthyosis.
Ogawa M, Akiyama M
Journal of the American Academy of Dermatology Vol. 71 ( 3 ) page： e103 - 5 2014.9
Books 1
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粉川 哲夫 , Meursault Pali, Ogawa Mariko（ Role： Sole author）
UV éditions 2019 （ ISBN:9782956275329 ）
KAKENHI (Grants-in-Aid for Scientific Research) 4
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Extracellular vesicle and autoantibody production
Grant number：23K15265 2023.4 - 2025.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Authorship：Principal investigator
Grant amount：\4680000 （ Direct Cost: \3600000 、 Indirect Cost：\1080000 ）
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アレルゲン特異的IgG4の経皮的感作、脱感作における機能解析
Grant number：19K17768 2021.11 - 2023.3
科学研究費助成事業 若手研究
桃原 真理子
Authorship：Principal investigator
Grant amount：\4160000 （ Direct Cost: \3200000 、 Indirect Cost：\960000 ）
1. 尋常性魚鱗癬患者におけるアレルゲン特異的IgEとIgG4の検討：尋常性魚鱗癬のアトピー群、非アトピー群、健常群の血清を用いて、吸入抗原、食物抗原、皮膚表在菌などの皮膚感作抗原に対する各群での抗体の有無の傾向や抗体価の比較をELISAで行う。
2. 抗炎症抗体としてのIgG4機能検討 ：アレルゲンと反応させた患者血清IgG4をM2マクロファージ（代替活性化マクロファージ）等と反応させ、活性化するかどうかを検証する。
3. 抗原に吸着したIgG4のB細胞活性制御に関する検討：魚鱗癬患者より採取したB細胞に、アレルゲンに吸着したIgG4を反応させ、IgG4、IgEの産生量変化を見る。
名古屋大学附属病院に採血、アンケート調査のための倫理申請を行い、2019年8月5日に前向き研究の許可を得た。アトピー性皮膚炎、先天性角化症患者さん、健常人へのアンケートおよび採血のご協力を得て、現在約70名ほどのデータと検体収集を行った。各アレルゲン（ヤケヒョウダニ、スギ、アスペルギルス、カンジタ、イヌ皮膚、黄色ブドウ球菌、マラセチア、アルテルナリア、卵白OVA）に対し、抗原を固相化したELISA法を用いて各患者およびコンロトール群の血清中のIgG4とIgE間の反応性を検体群ごとに比較した。
現時点までの検討では、各検体のIgG4とIgEの反応性の傾向（IgG４、IｇEが抗吸着される頻度とパターン）が、各群で抗原ごとに大きく異なり、アレルゲンごとの感作、脱感作の経路や形式、あるいはIgG4の持つ役割が異なる可能性が強く示唆された。
また、骨髄移植後のサンプルでは、寛解長期生存後もアレルギーの臨床症状を認めるものの、血清学的には全く反応を示していなかった例があり、別途検討を行う予定である。
本研究は患者検体100と健常人検体30以上を予定しており、今後も引き続き検体の収集を平行して行っていく予定である。また、アレルゲン毎に異なる反応性が見られたため、その傾向をさらに検討するためにアレルゲンの種類を拡大、改良し、ELISAの方法を画一していく予定となっている。当実験ではIgEの反応性がやや弱い傾向にあり、今後改良の必要があると考えている。また、はっきりとした反応が見られた検体に対し、肥満細胞や形質細胞を用いた血球レベルの実験を追加していく予定である。 -
Analysis of autoimmune responses against DNA mismatch repair enzymes in dermatomyositis
Grant number：26461656 2014.4 - 2018.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Muro Yoshinao, MOMOHARA MARIKO, YAMAMOTO ERI
Authorship：Other
DNA mismatch repair is an important life system, which is conserved from bacteria to human, and starts by mismatch recognition where seven kinds of enzymes are involved in human. We reported that patients with collagen diseases including inflammatory myopathy carry autoantibodies against four kinds of these enzymes. Further studies clarified that major targets of these antibodies are MLH1 and PMS1 and that some patients who had these antibodies also simultaneously carried other myositis-marker autoantibodies and other patients did not. We have found that commercially available substrates for indirect immunofluorescence tests were not suitable for the screening of autoantibodies against these enzymes and the suitable fixed cultured cells for the screening. Moreover, we have found the possibility that ultraviolet irradiation to cultured keratinocytes might influence the expression of these enzymes (autoantigens).
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Grant number：221S0001 2010.4 - 2016.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
IMAI Kohzoh, INOUE Junichiro, NAKAMURA Takuro, ISHIKAWA Fuyuki, YAMAMURA Kenichi, ARAKI Kimi, YAO Ryouji, TAKANO Hiroshi, TAKAKURA Akira, KATOH Hideki, NAKAGATA Naomi, TOYOKUNI Shinya, WANIBUCHI Hideki, OGAWA Katsuhiro, MITSUMORI Kunitoshi, YAMADA Yasuhiro, SHIBUTANI Makoto, IMAIDA Katsumi, FUTAKUCHI Mitsuru, KANDA Hiroaki, TANAKA Hideo, WAKAI Kenji, MIKAMI Haruo, SUZUKI Sadao, MIURA Katsuyuki, WATANABE Yoshiyuki, ARISAWA Kokichi, TANAKA Keitaro, TAKEZAKI Toshiro, FURUSHO Norihiro, NAITO Mariko, OHNAKA Keizo, KITA Yoshikuni, KURIKI Kiyonori, TAMAKAOSHI Akiko, EGUCHI Hidetaka, KUBO Michiaki, HAMAJIMA Nobuyuki, NAGATA Chisato, HINO Okio, TAHARA Hidetoshi, SUGIMURA Haruhiko, TSUGANE Shoichiro, NAKATOCHI Masahiro, TAKAYAMA Tetsuji, AKAZA Hideyuki, TAKAHASHI Satoru, TSUKAMOTO Taiji, NAITO Seiji, MASUMORI Naoya, YOKOMIZO Akira, NAMIKI Mikio, FUJIMOTO Kiyohide, FUJIOKA Tomoaki, HORIE Shigeo, MORI Mitsuru, MORIWAKI Hisataka, Shimizu Masahito, KANNAGI Mari, ISHIDA Takashi, MATSUOKA Masao, YAMAOKA Shoji, TANAKA Yuetsu, WATANABE Toshiki, YASUI Hiroshi, TSUCHIYA Eiju, DAIGO Yataro, MIYAGI Yohei, TAKAHASHI Takashi, YAMORI Takao, SEIMIYA Hiroyuki, UEHARA Yoshimasa, YOSHIDA Minoru, IMOTO Masaya, FUKAZAWA Hidesuke, KAKEYA Hideaki, DAN Shingo, TOMIDA Akihiro, KAWADA Manabu, OSADA Hiroyuki, MATSUURA Masaaki, MIZUKAMI Tamio, MASHIMA Tetsuo, USHIJIMA Masaru, TOKINO Takashi, SUZUKI Hiromu, SHINOMURA Yasuhisa, NOSHO Katsuhiko, MIYAZONO Kohei, INAZAWA Johji, HIROTA Toru, NODA Tetsuo, SUZUKI Misao, TAKEDA Naoki, YAGINUMA Katsuyuki, SUGITANI Yoshinobu, ITO Hidemi, HOSONO Satoyo, IWASAKI Motoki, NAGASE Hiroki, NISHITA Hiroki, KONO Suminori, HASHIMOTO Syuji, YAMAGUCHI Kazunari, TAKANO Atsushi, TERAMOTO Koji, MATSUDA Koichi, TANAKA Yukichi, AOKI Ichiro, OSAMURA Yoshiyuki, NAKAMURA Naoya, SUZUKI Noboru, TAJIRI Michihiko, KAWASAKI Takashi, YOKOSE Tomoyuki, YANAGISAWA Kiyoshi, HIRAKAWA Akihiro, IIJIMA Yoshihiko, ZEMBUTSU Hitoshi, SASAKI Yasushi, IDOGAWA Masashi, MARUYAMA Reo, KAI Masahiro
We started this project first supporting scientists who aim to overcome cancer, and from 2014 we extended our support to scientists in life sciences. The outcome has been as follows: General Support Group fostered young scientists and those who will be involved in research support in the future, and developed international academic exchanges. Our support services such as providing genetically modified mice and providing bioresources including cancer tissues enabled many scientists to conduct international and cutting-edge researches. All Japan Cohort Group and ATL Study Group (originated in Japan) collected more than 110,000 important samples and contributed for many scientists to produce their results. Chemotherapy Group and Genome and Epigenome Group also achieved more than their original goals. Further, we organized open lectures for general public to inform the importance of scientific support.