Updated on 2024/04/11

写真a

 
OHKA Fumiharu
 
Organization
Graduate School of Medicine Program in Integrated Medicine Clinical Neurosciences Lecturer
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine Department of Medicine
Title
Lecturer

Degree 1

  1. 博士(医学) ( 2013.3   名古屋大学 ) 

Research History 6

  1. 名古屋大学大学院医学系研究科   脳神経外科   講師

    2022.1

  2. 名古屋大学大学院医学系研究科   脳神経外科   助教

    2016.8 - 2021.12

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    Country:Japan

  3. 名古屋大学医学部附属病院   脳神経外科   病院助教

    2015.4 - 2016.7

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    Country:Japan

  4. 日本学術振興会特別研究員(PD)

    2014.4 - 2015.3

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    Country:Japan

  5. 愛知県がんセンター研究所   リサーチレジデント

    2012.4 - 2014.3

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    Country:Japan

  6. 名古屋大学医学部附属病院   医員

    2009.4 - 2010.3

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    Country:Japan

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Education 2

  1. Nagoya University   Graduate School, Division of Medical Sciences

    - 2013.3

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    Country: Japan

  2. Nagoya University   Faculty of Medicine

    - 2004.3

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    Country: Japan

Professional Memberships 5

  1. 日本脳神経外科学会

  2. 日本癌学会

  3. 日本脳腫瘍学会

  4. 日本脳腫瘍病理学会

  5. Society of Neuro-Oncology

Awards 5

  1. 第26回日本脳神経外科学会奨励賞

    2020.10   日本脳神経外科学会  

    大岡史治

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    Award type:Award from Japanese society, conference, symposium, etc.  Country:Japan

  2. Young Investigator Clinical Research Abstract Award

    2016.11   Society of Neuro-Oncology  

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    Award type:Award from international society, conference, symposium, etc.  Country:United States

  3. 学会賞

    2022.7   日本分子脳神経外科学会  

  4. 日本脳腫瘍病理学会・学会賞

    2018.9   日本脳腫瘍病理学会  

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    Award type:International academic award (Japan or overseas)  Country:Japan

  5. 名古屋大学医師会研究奨励賞

    2012   名古屋大学医師会  

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    Country:Japan

 

Papers 87

  1. Molecular insights and the role of 18F-FDG-PET/CT in the diagnosis of spinal gliomas.

    Nagashima Y, Nishimura Y, Eguchi K, Yamaguchi J, Haimoto S, Ohka F, Motomura K, Abe T, Matsuo M, Tsukamoto E, Hara M, Saito R

    Acta neurochirurgica   Vol. 166 ( 1 ) page: 154   2024.3

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    Language:English  

    DOI: 10.1007/s00701-024-06039-5

    PubMed

  2. Awake Craniotomy for Gliomas in the Non-Dominant Right Hemisphere: A Comprehensive Review

    Mamadaliev, DM; Saito, R; Motomura, K; Ohka, F; Scalia, G; Umana, GE; Conti, A; Chaurasia, B

    CANCERS   Vol. 16 ( 6 )   2024.3

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  3. Endoscopic debulking canalization for optic pathway glioma with obstructive hydrocephalus

    Takeuchi, K; Ohka, F; Nagata, Y; Ito, E; Harada, H; Saito, R

    CHILDS NERVOUS SYSTEM   Vol. 39 ( 12 ) page: 3421 - 3425   2023.12

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  4. Fifteen-Fraction Radiosurgery Followed by Reduced-Dose Whole-Brain Irradiation With a Total Biologically Effective Dose of >90-100 Gy for a Locally Invasive Brain Metastasis From Lung Adenocarcinoma With a High Dissemination Potential

    Ohtakara, K; Ohka, F; Tanahashi, K; Yamada, T; Suzuki, K

    CUREUS JOURNAL OF MEDICAL SCIENCE   Vol. 15 ( 11 ) page: e49596   2023.11

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  5. INTRA-OPERATIVE ANALYSES OF GENETIC ALTERATIONS IN THE CENTRAL NERVOUS SYSTEM TUMORS USING RAPID QUANTITATIVE PCR DEVICE

    Ohka, F; Maeda, S; Yamaguchi, J; Shimizu, H; Motomura, K; Takeuchi, K; Nagata, Y; Nishikawa, T; Kibe, Y; Takido, Y; Saito, R

    NEURO-ONCOLOGY   Vol. 25   2023.11

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  6. IMAGING FEATURES AND CONSIDERATION OF PROGRESSION PATTERN OF DIFFUSE HEMISPHERIC GLIOMAS, H3 G34-MUTANT

    Kibe, Y; Ohka, F; Motomura, K; Aoki, K; Maeda, S; Yamaguchi, J; Shimizu, H; Saito, R

    NEURO-ONCOLOGY   Vol. 25   2023.11

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  7. GLIOBLASTOMA, IDH-WILDTYPE WITHOUT KEY MOLECULAR FEATURES

    Saito, R; Motomura, K; Ohka, F; Yamaguchi, J; Maeda, S; Nishikawa, T; Mizutani, K; Kibe, Y; Shimizu, H; Takido, Y

    NEURO-ONCOLOGY   Vol. 25   2023.11

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  8. ESTABLISHMENT OF ORGANOID MODELS OF PATIENT-DERIVED GH-PRODUCING PITUITARY ADENOMA

    Maeda, S; Ohka, F; Kanamori, F; Okumura, Y; Takeuchi, K; Nagata, Y; Motomura, K; Yamaguchi, J; Kibe, Y; Harada, H; Shimizu, H; Takido, Y; Saito, R

    NEURO-ONCOLOGY   Vol. 25   2023.11

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  9. Development of machine learning models for predicting unfavorable functional outcomes from preoperative data in patients with chronic subdural hematomas

    Fuse, Y; Nagashima, Y; Nishiwaki, H; Ohka, F; Muramatsu, Y; Araki, Y; Nishimura, Y; Ienaga, J; Nagatani, T; Seki, Y; Watanabe, K; Ohno, K; Saito, R

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 16997   2023.10

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  10. Predictive factors of post-operative apathy in patients with diffuse frontal gliomas undergoing awake brain mapping

    Motomura, K; Kawamura, A; Ohka, F; Aoki, K; Nishikawa, T; Yamaguchi, J; Kibe, Y; Shimizu, H; Maeda, S; Saito, R

    JOURNAL OF NEUROPSYCHOLOGY     2023.9

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  11. TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation

    Suzuki, MM; Iijima, K; Ogami, K; Shinjo, K; Murofushi, Y; Xie, JQ; Wang, XB; Kitano, Y; Mamiya, A; Kibe, Y; Nishimura, T; Ohka, F; Saito, R; Sato, S; Kobayashi, J; Yao, R; Miyata, K; Kataoka, K; Suzuki, HI; Kondo, Y

    NATURE COMMUNICATIONS   Vol. 14 ( 1 ) page: 4521   2023.8

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  12. Mutation detection of urinary cell-free DNA via catch-and-release isolation on nanowires for liquid biopsy

    Takahashi, H; Yasui, T; Hirano, M; Shinjo, K; Miyazaki, Y; Shinoda, W; Hasegawa, T; Natsume, A; Kitano, Y; Ida, M; Zhang, M; Shimada, T; Paisrisarn, P; Zhu, ZT; Ohka, F; Aoki, K; Rahong, S; Nagashima, K; Yanagida, T; Baba, Y

    BIOSENSORS & BIOELECTRONICS   Vol. 234   page: 115318   2023.8

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  13. Latest classification of ependymoma in the molecular era and advances in its treatment: a review

    Yamaguchi, J; Ohka, F; Motomura, K; Saito, R

    JAPANESE JOURNAL OF CLINICAL ONCOLOGY   Vol. 53 ( 8 ) page: 653 - 663   2023.7

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  14. Brain metastasis and intracranial leptomeningeal metastasis from malignant peripheral nerve sheath tumors: illustrative cases.

    Ohno M, Haimoto S, Tsukushi S, Hosoda W, Ohka F, Saito R

    Journal of neurosurgery. Case lessons   Vol. 6 ( 3 )   2023.7

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    Language:English  

    DOI: 10.3171/CASE23148

    PubMed

  15. Efficacy and safety of bevacizumab, irinotecan, and temozolomide combination for relapsed or refractory pediatric central nervous system embryonal tumor: a single-institution study

    Shiba, Y; Motomura, K; Taniguchi, R; Kurimoto, M; Mizutani, K; Ohka, F; Aoki, K; Ito, E; Nishikawa, T; Yamaguchi, J; Kibe, Y; Shimizu, H; Maeda, S; Nakashima, T; Suzuki, H; Muramatsu, H; Takahashi, Y; Saito, R

    JOURNAL OF NEUROSURGERY-PEDIATRICS   Vol. 31 ( 6 ) page: 624 - 632   2023.6

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  16. Rapid detection of the <i>MYD88</i> L265P mutation for pre- and intra-operative diagnosis of primary central nervous system lymphoma

    Yamaguchi, J; Ohka, F; Kitano, Y; Maeda, S; Motomura, K; Aoki, K; Takeuchi, K; Nagata, Y; Hattori, H; Tsujiuchi, T; Motomura, A; Nishikawa, T; Kibe, Y; Shinjo, K; Kondo, Y; Saito, R

    CANCER SCIENCE   Vol. 114 ( 6 ) page: 2544 - 2551   2023.6

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  17. Clinical characteristics and radiological features of glioblastoma, <i>IDH</i>-wildtype, grade 4 with histologically lower-grade gliomas

    Motomura, K; Kibe, Y; Ohka, F; Aoki, K; Yamaguchi, J; Saito, R

    BRAIN TUMOR PATHOLOGY   Vol. 40 ( 2 ) page: 48 - 55   2023.4

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  18. Easy-to-use machine learning system for the prediction of IDH mutation and 1p/19q codeletion using MRI images of adult-type diffuse gliomas

    Nishikawa, T; Ohka, F; Aoki, K; Suzuki, H; Motomura, K; Yamaguchi, J; Maeda, S; Kibe, Y; Shimizu, H; Natsume, A; Innan, H; Saito, R

    BRAIN TUMOR PATHOLOGY   Vol. 40 ( 2 ) page: 85 - 92   2023.4

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  19. <i>CD79B</i> Y196 mutation is a potent predictive marker for favorable response to R-MPV in primary central nervous system lymphoma

    Yamaguchi, J; Ohka, F; Lushun, C; Motomura, K; Aoki, K; Takeuchi, K; Nagata, Y; Ito, S; Mizutani, N; Ohno, M; Suzaki, N; Takasu, S; Seki, Y; Kano, T; Wakabayashi, K; Oyama, H; Kurahashi, S; Tanahashi, K; Hirano, M; Shimizu, H; Kitano, Y; Maeda, S; Yamazaki, S; Wakabayashi, T; Kondo, Y; Natsume, A; Saito, R

    CANCER MEDICINE   Vol. 12 ( 6 ) page: 7116 - 7126   2023.3

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  20. Identification of therapeutic targets exhibiting synthetic lethality with IDH1 inhibitor using the CRISPR/Cas9 system

    Maeda, S; Aoki, K; Hinohara, K; Yamaguchi, J; Ohka, F; Natsume, A; Saito, R

    CANCER SCIENCE   Vol. 114   page: 1460 - 1460   2023.2

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  21. Intra-operative analysis of genetic alterations in brain tumor using rapid quantitative PCR device

    Ohka, F; Maeda, S; Yamaguchi, J; Motomura, K; Saito, R

    CANCER SCIENCE   Vol. 114   page: 1818 - 1818   2023.2

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  22. All-in-One Nanowire Assay System for Capture and Analysis of Extracellular Vesicles from an<i> ex</i><i> Vivo</i> Brain Tumor Model

    Chattrairat, K; Yasui, T; Suzuki, S; Natsume, A; Nagashima, K; Iida, M; Zhang, M; Shimada, T; Kato, A; Aoki, K; Ohka, F; Yamazaki, S; Yanagida, T; Baba, Y

    ACS NANO   Vol. 17 ( 3 ) page: 2235 - 2244   2023.1

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  23. Imaging features of localized <i>IDH</i> wild-type histologically diffuse astrocytomas: a single-institution case series

    Kibe, Y; Motomura, K; Ohka, F; Aoki, K; Shimizu, H; Yamaguchi, J; Nishikawa, T; Saito, R

    SCIENTIFIC REPORTS   Vol. 13 ( 1 ) page: 23   2023.1

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  24. CLINICAL AND MOLECULAR FEATURES OF GLIOBLASTOMA, IDH-WILDTYPE ARISING IN THE SETTING OF LI FRAUMENI SYNDROME

    Kibe, Y; Ohka, F; Motomura, K; Aoki, K; Maeda, S; Yamaguchi, J; Nishikawa, T; Mizutani, K; Shimizu, H; Hiramatsu, T; Suzuki, K; Saito, R

    NEURO-ONCOLOGY   Vol. 24   page: 154 - 154   2022.11

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  25. ROLE OF CD79B Y196 MUTATION IN PCNSL AS A POTENT PREDICTIVE MARKER FOR FAVORABLE RESPONSE TO R-MPV TREATMENT AND DEVELOPMENT OF RAPID ALL-IN-ONE GENOTYPING SYSTEM FOR MOLECULAR MARKERS OF PCNSL

    Yamaguchi, J; Ohka, F; Lushun, C; Motomura, K; Aoki, K; Takeuchi, K; Nagata, Y; Ito, S; Mizutani, N; Ohno, M; Suzaki, N; Takasu, S; Seki, Y; Tanahashi, K; Hirano, M; Shimizu, H; Kitano, Y; Maeda, S; Yamazaki, S; Wakabayashi, T; Kondo, Y; Saito, R

    NEURO-ONCOLOGY   Vol. 24   page: 18 - 18   2022.11

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  26. IDENTIFICATION OF A NOVEL THERAPEUTIC TARGET THAT IS SYNTHETICALLY LETHAL WITH MUTANT IDH INHIBITOR IN GLIOMA USING THE CRISPR/CAS9 GENOME EDITING TECHNOLOGY

    Maeda, S; Aoki, K; Hinohara, K; Yamaguchi, J; Ohka, F; Motomura, K; Kibe, Y; Natsume, A; Saito, R

    NEURO-ONCOLOGY   Vol. 24   page: 107 - 107   2022.11

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  27. Endoscopic Trans-Mini-Cylinder Biopsy for Intraparenchymal Brain Lesions

    Takeuchi, K; Ohka, F; Nagata, Y; Maeda, S; Tanahashi, K; Araki, Y; Yamamoto, T; Sasaki, H; Mizuno, A; Harada, H; Saito, R

    WORLD NEUROSURGERY   Vol. 167   page: E1147 - E1153   2022.11

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  28. Primary central nervous system malignant lymphoma in a patient with rheumatoid arthritis receiving tocilizumab: illustrative case.

    Ohno M, Kuramitsu S, Iwakoshi A, Yamaguchi J, Ohka F, Saito R

    Journal of neurosurgery. Case lessons   Vol. 4 ( 6 )   2022.8

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    Language:English  

    DOI: 10.3171/CASE22256

    PubMed

  29. Direct intracranial invasion of eccrine spiradenocarcinoma of the scalp: a case report and literature review

    Kibe, Y; Tanahashi, K; Ohtakara, K; Okumura, Y; Ohka, F; Takeuchi, K; Nagata, Y; Motomura, K; Akahori, S; Mizuno, A; Sasaki, H; Shimizu, H; Yamaguchi, J; Nishikawa, T; Yokota, K; Saito, R

    BMC NEUROLOGY   Vol. 22 ( 1 ) page: 223   2022.6

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  30. Recent Molecular and Genetic Findings in Intramedullary Spinal Cord Tumors

    Nagashima, Y; Nishimura, Y; Eguchi, K; Yamaguchi, J; Haimoto, S; Ohka, F; Takayasu, M; Saito, R

    NEUROSPINE   Vol. 19 ( 2 ) page: 262 - 271   2022.6

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  31. Supratotal Resection of Gliomas With Awake Brain Mapping: Maximal Tumor Resection Preserving Motor, Language, and Neurocognitive Functions

    Motomura, K; Ohka, F; Aoki, K; Saito, R

    FRONTIERS IN NEUROLOGY   Vol. 13   page: 874826   2022.5

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  32. Increased Risk of Thyroid Dysfunction by PD-1 and CTLA-4 Blockade in Patients Without Thyroid Autoantibodies at Baseline

    Iwama, S; Kobayashi, T; Yasuda, Y; Okuji, T; Ito, M; Ando, M; Zhou, X; Yamagami, A; Onoue, T; Kawaguchi, Y; Miyata, T; Sugiyama, M; Takagi, H; Hagiwara, D; Suga, H; Banno, R; Hase, T; Morise, M; Wakahara, K; Yokota, K; Kato, M; Nishio, N; Tanaka, C; Miyata, K; Ogura, A; Ito, T; Sawada, T; Shimokata, T; Niimi, K; Ohka, F; Ishigami, M; Gotoh, M; Hashimoto, N; Saito, R; Kiyoi, H; Kajiyama, H; Ando, Y; Hibi, H; Sone, M; Akiyama, M; Kodera, Y; Arima, H

    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM   Vol. 107 ( 4 ) page: E1620 - E1630   2022.3

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  33. Reliability of IDH1-R132H and ATRX and/or p53 immunohistochemistry for molecular subclassification of Grade 2/3 gliomas

    Nishikawa, T; Watanabe, R; Kitano, Y; Yamamichi, A; Motomura, K; Ohka, F; Aoki, K; Hirano, M; Kato, A; Yamaguchi, J; Maeda, S; Kibe, Y; Saito, R; Wakabayashi, T; Kato, Y; Sato, S; Ogino, T; Natsume, A; Ito, I

    BRAIN TUMOR PATHOLOGY   Vol. 39 ( 1 ) page: 14 - 24   2022.1

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  34. (11)C-methionine- and (18)F-FDG-PET double-negative metastatic brain tumor from lung adenocarcinoma with paradoxical high (18)F-FDG uptake: A case report.

    Tanahashi K, Hirano M, Chalise L, Tsugawa T, Okumura Y, Hase T, Ohka F, Motomura K, Takeuchi K, Nagata Y, Nakahara N, Hashimoto N, Saito R

    Surgical neurology international   Vol. 13   page: 372   2022

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    Language:English  

    DOI: 10.25259/SNI_264_2022

    PubMed

  35. Dural Arteriovenous Fistula Mimicking a Brain Tumor on Methionine-positron Emission Tomography: A Case Report.

    Hanyu T, Nishihori M, Izumi T, Motomura K, Ohka F, Goto S, Araki Y, Yokoyama K, Uda K, Saito R

    NMC case report journal   Vol. 9   page: 289 - 294   2022

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    DOI: 10.2176/jns-nmc.2022-0055

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  36. Newly established patient-derived organoid model of intracranial meningioma

    Yamazaki, S; Ohka, F; Hirano, M; Shiraki, Y; Motomura, K; Tanahashi, K; Tsujiuchi, T; Motomura, A; Aoki, K; Shinjo, K; Murofushi, Y; Kitano, Y; Maeda, S; Kato, A; Shimizu, H; Yamaguchi, J; Adilijiang, A; Wakabayashi, T; Saito, R; Enomoto, A; Kondo, Y; Natsume, A

    NEURO-ONCOLOGY   Vol. 23 ( 11 ) page: 1936 - 1948   2021.11

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  37. Intraoperative seizure outcome of levetiracetam combined with perampanel therapy in patients with glioma undergoing awake brain surgery

    Motomura, K; Chalise, L; Shimizu, H; Yamaguchi, J; Nishikawa, T; Ohka, F; Aoki, K; Tanahashi, K; Hirano, M; Wakabayashi, T; Natsume, A

    JOURNAL OF NEUROSURGERY   Vol. 135 ( 4 ) page: 998 - 1007   2021.10

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  38. Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury

    Nagashima, Y; Nishimura, Y; Ohka, F; Eguchi, K; Aoki, K; Ito, H; Nishii, T; Oyama, T; Hara, M; Kitano, Y; Masaki, H; Wakabayashi, T; Natsume, A

    CELLS   Vol. 10 ( 10 )   2021.10

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  39. Mathematical Modeling and Mutational Analysis Reveal Optimal Therapy to Prevent Malignant Transformation in Grade II IDH-Mutant Gliomas

    Aoki, K; Suzuki, H; Yamamoto, T; Yamamoto, KN; Maeda, S; Okuno, Y; Ranjit, M; Motomura, K; Ohka, F; Tanahashi, K; Hirano, M; Nishikawa, T; Shimizu, H; Kitano, Y; Yamaguchi, J; Yamazaki, S; Nakamura, H; Takahashi, M; Narita, Y; Nakada, M; Deguchi, S; Mizoguchi, M; Momii, Y; Muragaki, Y; Abe, T; Akimoto, J; Wakabayashi, T; Saito, R; Ogawa, S; Haeno, H; Natsume, A

    CANCER RESEARCH   Vol. 81 ( 18 ) page: 4861 - 4873   2021.9

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  40. Long-term survival in patients with primary intracranial germ cell tumors treated with surgery, platinum-based chemotherapy, and radiotherapy: a single-institution study.

    Shimizu H, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Yamaguchi J, Yoshida J, Natsume A, Wakabayashi T

    Journal of neurosurgery   Vol. 135 ( 2 ) page: 449 - 457   2021.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3171/2020.6.JNS20638

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    PubMed

  41. Impact of the extent of resection on the survival of patients with grade II and III gliomas using awake brain mapping

    Motomura, K; Chalise, L; Ohka, F; Aoki, K; Tanahashi, K; Hirano, M; Nishikawa, T; Yamaguchi, J; Shimizu, H; Wakabayashi, T; Saito, R

    JOURNAL OF NEURO-ONCOLOGY   Vol. 153 ( 2 ) page: 361 - 372   2021.6

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  42. Urinary MicroRNA-Based Diagnostic Model for Central Nervous System Tumors Using Nanowire Scaffolds

    Kitano, Y; Aoki, K; Ohka, F; Yamazaki, S; Motomura, K; Tanahashi, K; Hirano, M; Naganawa, T; Iida, M; Shiraki, Y; Nishikawa, T; Shimizu, H; Yamaguchi, J; Maeda, S; Suzuki, H; Wakabayashi, T; Baba, Y; Yasui, T; Natsume, A

    ACS APPLIED MATERIALS & INTERFACES   Vol. 13 ( 15 ) page: 17316 - 17329   2021.4

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  43. Expression of programmed cell death ligand-1 by immune cells in the microenvironment is a favorable prognostic factor for primary diffuse large B-cell lymphoma of the central nervous system.

    Tsuyuki Y, Ishikawa E, Kohno K, Shimada K, Ohka F, Suzuki Y, Mabuchi S, Satou A, Takahara T, Kato S, Miyagi S, Ozawa H, Kawano T, Takagi Y, Hiraga J, Wakabayashi T, Nakamura S

    Neuropathology : official journal of the Japanese Society of Neuropathology   Vol. 41 ( 2 ) page: 99 - 108   2021.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/neup.12705

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  44. Trautmann-focused mastoidectomy for a simple, safe presigmoid approach: technical note.

    Tanahashi K, Uda K, Araki Y, Takeuchi K, Choo J, Chalise L, Motomura K, Ohka F, Wakabayashi T, Natsume A

    Journal of neurosurgery   Vol. 134 ( 3 ) page: 843 - 847   2021.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3171/2020.1.JNS193179

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  45. <i>Neurod4</i> converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury

    Fukuoka, T; Kato, A; Hirano, M; Ohka, F; Aoki, K; Awaya, T; Adilijiang, A; Sachi, M; Tanahashi, K; Yamaguchi, J; Motomura, K; Shimizu, H; Nagashima, Y; Ando, R; Wakabayashi, T; Lee-Liu, D; Larrain, J; Nishimura, Y; Natsume, A

    ISCIENCE   Vol. 24 ( 2 ) page: 102074   2021.2

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  46. Survival Benefit of Supratotal Resection in a Long-term Survivor of IDH-wildtype Glioblastoma: A Case Report and Literature Review.

    Yamaguchi J, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Shimizu H, Natsume A, Wakabayashi T, Saito R

    NMC case report journal   Vol. 8 ( 1 ) page: 747 - 753   2021

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    Language:English  

    DOI: 10.2176/nmccrj.cr.2021-0120

    PubMed

  47. INFANTILE HEMISPHERIC BRAIN TUMOR WITH A GOPC-ROS1 FUSION GENE: A CASE REPORT

    Taniguchi, R; Natsume, A; Kawashima, N; Tanioka, S; Muramatsu, H; Hamada, M; Ichikawa, D; Imaya, M; Narita, K; Kurimoto, M; Shiba, Y; Aoki, K; Ohka, F; Hirato, J; Wakabayashi, T; Takahashi, Y

    NEURO-ONCOLOGY   Vol. 22   page: 377 - 377   2020.12

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    Language:Japanese  

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  48. Solitary fibrous tumor/hemangiopericytoma treated with temozolomide plus bevacizumab: a report of four cases and literature review

    Maeda, O; Ohka, F; Maesawa, S; Matsuoka, A; Shimokata, T; Mitsuma, A; Urakawa, H; Nakamura, S; Shimoyamas, Y; Nakaguro, SM; Wakabayashi, T; Ando, Y

    NAGOYA JOURNAL OF MEDICAL SCIENCE   Vol. 82 ( 4 ) page: 631 - 644   2020.11

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  49. Neurocognitive and functional outcomes in patients with diffuse frontal lower-grade gliomas undergoing intraoperative awake brain mapping.

    Motomura K, Chalise L, Ohka F, Aoki K, Tanahashi K, Hirano M, Nishikawa T, Yamaguchi J, Shimizu H, Wakabayashi T, Natsume A

    Journal of neurosurgery   Vol. 132 ( 6 ) page: 1683 - 1691   2020.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3171/2019.3.JNS19211

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    PubMed

  50. Steroid-responsive recurrent tumefactive demyelination with multiple petechial hemorrhages along non-displaced medullary veins.

    Tsuboi T, Harada Y, Suzuki M, Ando T, Atsuta N, Ohka F, Takeuchi K, Taoka T, Ohba S, Nakaguro M, Abe M, Nakashima I, Yoshida M, Katsuno M

    Clinical neurology and neurosurgery   Vol. 193   page: 105764   2020.6

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    DOI: 10.1016/j.clineuro.2020.105764

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  51. Genetic analysis in patients with newly diagnosed glioblastomas treated with interferon-beta plus temozolomide in comparison with temozolomide alone

    Natsume Atsushi, Aoki Kosuke, Ohka Fumiharu, Maeda Sachi, Hirano Masaki, Adilijiang Alimu, Motomura Kazuya, Sumi Minako, Nishikawa Ryo, Narita Yoshitaka, Muragaki Yoshihiro, Maruyama Takashi, Ito Tamio, Beppu Takaaki, Nakamura Hideo, Kayama Takamasa, Sato Shinya, Nagane Motoo, Mishima Kazuhiko, Nakasu Yoko, Kurisu Kaoru, Yamasaki Fumiyuki, Sugiyama Kazuhiko, Onishi Takanori, Iwadate Yasuo, Terasaki Mizuhiko, Kobayashi Hiroyuki, Matsumura Akira, Ishikawa Eiichi, Sasaki Hikaru, Mukasa Akitake, Matsuo Takayuki, Hirano Hirofumi, Kumabe Toshihiro, Shinoura Nobusada, Hashimoto Naoya, Aoki Tomokazu, Asai Akio, Abe Tatsuya, Yoshino Atsuo, Arakawa Yoshiki, Asano Kenichiro, Yoshimoto Koji, Shibui Soichiro, Okuno Yusuke, Wakabayashi Toshihiko

    JOURNAL OF NEURO-ONCOLOGY   Vol. 148 ( 1 ) page: 17 - 27   2020.5

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    DOI: 10.1007/s11060-020-03505-9

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  52. H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant

    Maeda Sachi, Ohka Fumiharu, Okuno Yusuke, Aoki Kosuke, Motomura Kazuya, Takeuchi Kazuhito, Kusakari Hironao, Yanagisawa Nobuyuki, Sato Shinya, Yamaguchi Junya, Tanahashi Kuniaki, Hirano Masaki, Kato Akira, Shimizu Hiroyuki, Kitano Yotaro, Yamazaki Shintaro, Yamashita Shinji, Takeshima Hideo, Shinjo Keiko, Kondo Yutaka, Wakabayashi Toshihiko, Natsume Atsushi

    ACTA NEUROPATHOLOGICA COMMUNICATIONS   Vol. 8 ( 1 ) page: 8   2020.2

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    DOI: 10.1186/s40478-020-0882-4

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  53. Multiple metastases to the bone and bone marrow from a 1p/19q-codeleted and <i>IDH2</i>-mutant anaplastic oligodendroglioma: a case report and literature review.

    Shimizu H, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Chalise L, Nishikawa T, Yamaguchi J, Wakabayashi T, Natsume A

    Neuro-oncology advances   Vol. 2 ( 1 ) page: vdaa101   2020.1

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    DOI: 10.1093/noajnl/vdaa101

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  54. MACHINE LEARNING TO DETECT GLIOMAS IN URINE-BASED LIQUID BIOPSY

    Kitano Yotaro, Aoki Kosuke, Yasui Takao, Motomura Kazuya, Ohka Fumiharu, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Shimizu Hiroyuki, Yamaguchi Junya, Maeda Sachi, Yamazaki Shintaro, Wakabayashi Toshihiko, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 21   page: 151 - 151   2019.11

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  55. Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-wild-type Diffuse Astrocytic Gliomas.

    Cancer research   Vol. 79 ( 19 ) page: 4814 - 4827   2019.10

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    DOI: 10.1158/0008-5472.CAN-19-1272

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  56. Spontaneous Tumor Regression of Intracranial Solitary Fibrous Tumor Originating From the Medulla Oblongata: A Case Report and Literature Review.

    Yamaguchi J, Motomura K, Ohka F, Aoki K, Tanahashi K, Hirano M, Nishikawa T, Shimizu H, Wakabayashi T, Natsume A

    World neurosurgery   Vol. 130   page: 400 - 404   2019.10

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    DOI: 10.1016/j.wneu.2019.07.052

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  57. Next Generation Sequencing-Based Transcriptome Predicts Bevacizumab Efficacy in Combination with Temozolomide in Glioblastoma.

    Adilijiang A, Hirano M, Okuno Y, Aoki K, Ohka F, Maeda S, Tanahashi K, Motomura K, Shimizu H, Yamaguchi J, Wakabayashi T, Natsume A

    Molecules (Basel, Switzerland)   Vol. 24 ( 17 )   2019.9

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    DOI: 10.3390/molecules24173046

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  58. Aberrant Active cis-Regulatory Elements Associated with Downregulation of RET Finger Protein Overcome Chemoresistance in Glioblastoma

    Ranjit Melissa, Hirano Masaki, Aoki Kosuke, Okuno Yusuke, Ohka Fumiharu, Yamamichi Akane, Kato Akira, Maeda Sachi, Motomura Kazuya, Matsuo Keitaro, Enomoto Atsushi, Ino Yasushi, Todo Tomoki, Takahashi Masahide, Wakabayashi Toshihiko, Kato Takuya, Natsume Atsushi

    CELL REPORTS   Vol. 26 ( 9 ) page: 2274 - +   2019.2

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    DOI: 10.1016/j.celrep.2019.01.109

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  59. Aberrant active-enhancers associated with downregulation of HDAC1-RFP complex overcome chemoresistance in glioblastoma

    Hirano Masaki, Melissa Ranjit, Ohka Fumiharu, Aoki Kosuke, Yamamichi Akane, Kato Takuya, Matsuo Keitaro, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

    CANCER SCIENCE   Vol. 109   page: 207 - 207   2018.12

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  60. Development of anticancer agents targeting long non-coding RNA

    Katsushima Keisuke, Natsume Atsushi, Ohka Fumiharu, Shinjo Keiko, Shibata Tatsuhiro, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka

    CANCER SCIENCE   Vol. 109   page: 352 - 352   2018.12

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  61. ABERRANT ACTIVE-ENHANCERS ASSOCIATED WITH DOWNREGULATION OF HDAC1-RET FINGER PROTEIN COMPLEX OVERCOME CHEMORESISTANCE IN GLIOBLASTOMA

    Hirano Masaki, Ranjit Melissa, Ohka Fumiharu, Aoki Kosuke, Yamamichi Akane, Kato Takuya, Matsuo Keitaro, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 20   page: 111 - 111   2018.11

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  62. Validation of a novel molecular RPA classification in glioblastoma (GBM-molRPA) treated with chemoradiation: A multi-institutional collaborative study

    Wee Chan Woo, Kim Il Han, Park Chul-Kee, Kim Jin Wook, Dho Yun-Sik, Ohka Fumiharu, Aoki Kosuke, Motomura Kazuya, Natsume Atsushi, Kim Nalee, Suh Chang-Ok, Chang Jong Hee, Kim Se Hoon, Cho Won Kyung, Lim Do Hoon, Nam Do-Hyun, Choi Jung Won, Kim In Ah, Kim Chae-Yong, Oh Young-Taek, Cho Oyeon, Chung Woong-Ki, Kim Sung-Hwan, Kim Eunji

    RADIOTHERAPY AND ONCOLOGY   Vol. 129 ( 2 ) page: 347 - 351   2018.11

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    DOI: 10.1016/j.radonc.2018.09.001

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  63. Supratotal Resection of Diffuse Frontal Lower Grade Gliomas with Awake Brain Mapping, Preserving Motor, Language, and Neurocognitive Functions

    Motomura Kazuya, Chalise Lushun, Ohka Fumiharu, Aoki Kosuke, Tanahashi Kuniaki, Hirano Masaki, Nishikawa Tomohide, Wakabayashi Toshihiko, Natsume Atsushi

    WORLD NEUROSURGERY   Vol. 119   page: 30 - 39   2018.11

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    DOI: 10.1016/j.wneu.2018.07.193

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  64. Characterization of lntraoperative Motor Evoked Potential Monitoring for Surgery of the Pediatric Population with Brain Tumors

    Motomura Kazuya, Sumita Kayo, Chalise Lushun, Nishikawa Tomohide, Tanahashi Kuniaki, Ohka Fumiharu, Aoki Kosuke, Hirano Masaki, Nakamura Tomohiko, Matsushita Tadashi, Wakabayashi Toshihiko, Natsume Atsushi

    WORLD NEUROSURGERY   Vol. 119   page: E1052 - E1059   2018.11

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    DOI: 10.1016/j.wneu.2018.08.039

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  65. Neuroendoscopic Cylinder Surgery and 5-Aminolevulinic Acid Photodynamic Diagnosis of Deep-Seated Intracranial Lesions

    Choo Jungsu, Takeuchi Kazuhito, Nagata Yuichi, Ohka Fumiharu, Kishida Yugo, Watanabe Tadashi, Satoh Yusuke, Nagatani Tetsuya, Kato Kyozo, Wakabayashi Toshihiko, Natsume Atsushi

    WORLD NEUROSURGERY   Vol. 116   page: E35 - E41   2018.8

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    DOI: 10.1016/j.wneu.2018.03.112

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  66. Immunohistochemical ATRX expression is not a surrogate for 1p19q codeletion

    Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Kato Akira, Hirano Masaki, Motomura Kazuya, Tanahashi Kuniaki, Chalise Lushun, Maeda Sachi, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

    BRAIN TUMOR PATHOLOGY   Vol. 35 ( 2 ) page: 106 - 113   2018.4

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    DOI: 10.1007/s10014-018-0312-5

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  67. A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR.

    Hirano M, Ohka F, Maeda S, Chalise L, Yamamichi A, Aoki K, Kato A, Tanahashi K, Motomura K, Nishimura Y, Hara M, Shinjo K, Kondo Y, Wakabayashi T, Natsume A

    Brain tumor pathology   Vol. 35 ( 2 ) page: 97 - 105   2018.4

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    DOI: 10.1007/s10014-018-0310-7

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  68. Prognostic relevance of genetic alterations in diffuse lower-grade gliomas

    Aoki Kosuke, Nakamura Hideo, Suzuki Hiromichi, Matsuo Keitaro, Kataoka Keisuke, Shimamura Teppei, Motomura Kazuya, Ohka Fumiharu, Shiina Satoshi, Yamamoto Takashi, Nagata Yasunobu, Yoshizato Tetsuichi, Mizoguchi Masahiro, Abe Tatsuya, Momii Yasutomo, Muragaki Yoshihiro, Watanabe Reiko, Ito Ichiro, Sanada Masashi, Yajima Hironori, Morita Naoya, Takeuchi Ichiro, Miyano Satoru, Wakabayashi Toshihiko, Ogawa Seishi, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 20 ( 1 ) page: 66 - 77   2018.1

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    DOI: 10.1093/neuonc/nox132

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  69. Aberrant super-enhancers associated with downregulation of RET finger protein overcomes chemoresistance in glioblastoma

    Hirano Masaki, Ranjit Melissa, Yamamichi Akane, Aoki Kosuke, Ohka Fumiharu, Kato Takuya, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

    CANCER SCIENCE   Vol. 109   page: 461 - 461   2018.1

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  70. Targeting Dysregulation of EZH2-H3K27me3 as an Effective Treatment for IDH-wildtype Lower Grade Glioma

    Ohka Fumiharu, Natsume Atsushi, Suzuki Hiromichi, Aoki Kosuke, Deguchi Shoichi, Katsushima Keisuke, Shinjo Keiko, Wakabayashi Toshihiko, Kondo Yutaka

    CANCER SCIENCE   Vol. 109   page: 463 - 463   2018.1

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  71. Does ATRX immunohistochemistry deserve a surrogate of 1p/19q codel in grade II, III gliomas?

    Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Hirano Masaki, Motomura Kazuya, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

    CANCER SCIENCE   Vol. 109   page: 926 - 926   2018.1

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  72. Development of anticancer agents targeting long non-coding RNA TUG1

    Katsushima Keisuke, Natsume Atsushi, Ohka Fumiharu, Deguchi Shoichi, Shinjo Keiko, Shibata Tatsuhiro, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka

    CANCER SCIENCE   Vol. 109   page: 398 - 398   2018.1

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    Web of Science

  73. Significance of perivascular tumour cells defined by CD109 expression in progression of glioma

    Shiraki Yukihiro, Mii Shinji, Enomoto Atsushi, Momota Hiroyuki, Han Yi-Peng, Kato Takuya, Ushida Kaori, Kato Akira, Asai Naoya, Murakumo Yoshiki, Aoki Kosuke, Suzuki Hiromichi, Ohka Fumiharu, Wakabayashi Toshihiko, Todo Tomoki, Ogawa Seishi, Natsume Atsushi, Takahashi Masahide

    JOURNAL OF PATHOLOGY   Vol. 243 ( 4 ) page: 468 - 480   2017.12

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    DOI: 10.1002/path.4981

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  74. Organotypic brain explant culture as a drug evaluation system for malignant brain tumors

    Minami Noriaki, Maeda Yusuke, Shibao Shunsuke, Arima Yoshimi, Ohka Fumiharu, Kondo Yutaka, Maruyama Koji, Kusuhara Masatoshi, Sasayama Takashi, Kohmura Eiji, Saya Hideyuki, Sampetrean Oltea

    CANCER MEDICINE   Vol. 6 ( 11 ) page: 2635 - 2645   2017.11

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    DOI: 10.1002/cam4.1174

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  75. Negative impact of leukoaraiosis on the incidence of brain metastases in patients with lung cancer

    Hayashi Nakamasa, Mitsuya Koichi, Nakasu Yoko, Naito Tateaki, Ohka Fumiharu, Takahashi Toshiaki

    JOURNAL OF NEURO-ONCOLOGY   Vol. 135 ( 2 ) page: 299 - 306   2017.11

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    DOI: 10.1007/s11060-017-2574-x

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  76. Remote ischemic preconditioning protects human neural stem cells from oxidative stress

    Motomura Ayako, Shimizu Mikiko, Kato Akira, Motomura Kazuya, Yamamichi Akane, Koyama Hiroko, Ohka Fumiharu, Nishikawa Tomohide, Nishimura Yusuke, Hara Masahito, Fukuda Tetsuya, Bando Yasuhiko, Nishimura Toshihide, Wakabayashi Toshihiko, Natsume Atsushi

    APOPTOSIS   Vol. 22 ( 11 ) page: 1353 - 1361   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s10495-017-1425-8

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  77. ABERRANT SUPER-ENHANCERS ASSOCIATED WITH DOWNREGULATION OF RET FINGER PROTEIN OVERCOMES CHEMORESISTANCE IN GLIOBLASTOMA

    Hirano Masaki, Ranjit Melissa, Yamamichi Akane, Aoki Kosuke, Ohka Fumiharu, Kato Takuya, Enomoto Atsushi, Takahashi Masahide, Wakabayashi Toshihiko, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 19   page: 103 - 103   2017.11

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  78. POLYION COMPLEX-MEDIATED INTRAVENOUS DELIVERY OF ANTISENSE OLIGONUCLEOTIDES AGAINST THE NOTCH-REGULATED NON-CODING RNA TUG1 IN GLIOMA

    Natsume Atsushi, Katsushima Keisuke, Ohka Fumiharu, Shinjo Keiko, Miyata Kanjiro, Kataoka Kazunori, Kondo Yutaka

    NEURO-ONCOLOGY   Vol. 19   page: 265 - 265   2017.11

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  79. IS ATRX IMMUNOCHEMISTRY USEFUL AS A SUBSTITUTE FOR ANALYSIS OF 1p/19q CODELETION IN GRADES II, III GLIOMAS?

    Yamamichi Akane, Ohka Fumiharu, Aoki Kosuke, Suzuki Hiromichi, Hirano Masaki, Motomura Kazuya, Wakabayashi Toshihiko, Kato Yukinari, Natsume Atsushi

    NEURO-ONCOLOGY   Vol. 19   page: 180 - 180   2017.11

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  80. Comparing the Efficacy of DeVIC Therapy and High-dose Methotrexate Monotherapy with Whole-brain Radiation Therapy for Newly-diagnosed Primary Central Nervous System Lymphoma: A Single Institution Study

    Chalise Lushun, Motomura Kazuya, Ohka Fumiharu, Hirano Masaki, Hara Masahito, Nishimura Yusuke, Natsume Atsushi, Wakabayashi Toshihiko

    ANTICANCER RESEARCH   Vol. 37 ( 9 ) page: 5215 - 5223   2017.9

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    DOI: 10.21873/anticanres.11945

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  81. Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis

    Deguchi S., Katsushima K., Hatanaka A., Shinjo K., Ohka F., Wakabayashi T., Zong H., Natsume A., Kondo Y.

    ONCOGENE   Vol. 36 ( 32 ) page: 4629 - 4640   2017.8

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    DOI: 10.1038/onc.2017.88

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  82. PHASE I TRIAL OF TEMOZOLOMIDE PLUS BEVACIZUMAB FOR NEWLY DIAGNOSED HIGH-GRADE GLIOMAS IN THE ELDERLY: INTERIM REPORT

    Kono M., Arakawa Y., Mineharu Y., Ohka F., Kinoshita M., Nakae S., Miyashita K., Iuchi T., Hirose Y., Natsume A., Nakada M., Sasaki H.

    NEURO-ONCOLOGY   Vol. 19   page: 81 - 81   2017.5

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  83. Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells

    Han Yi-Peng, Enomoto Atsushi, Shiraki Yukihiro, Wang Shen-Qi, Wang Xiaoze, Toyokuni Shinya, Asai Naoya, Ushida Kaori, Ara Hosne, Ohka Fumiharu, Wakabayashi Toshihiko, Ma Jie, Natsume Atsushi, Takahashi Masahide

    NEURO-ONCOLOGY   Vol. 19 ( 5 ) page: 636 - 647   2017.5

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    DOI: 10.1093/neuonc/now237

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  84. A novel all-in-one intraoperative genotyping system for IDH1-mutant glioma

    Ohka Fumiharu, Yamamichi Akane, Kurimoto Michihiro, Motomura Kazuya, Tanahashi Kuniaki, Suzuki Hiromichi, Aoki Kosuke, Deguchi Shoichi, Chalise Lushun, Hirano Masaki, Kato Akira, Nishimura Yusuke, Hara Masahito, Kato Yukinari, Wakabayashi Toshihiko, Natsume Atsushi

    BRAIN TUMOR PATHOLOGY   Vol. 34 ( 2 ) page: 91 - 97   2017.4

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    DOI: 10.1007/s10014-017-0281-0

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  85. Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation

    Fumiharu Ohka, Maki Ito, Melissa Ranjit, Takeshi Senga, Ayako Motomura, Kazuya Motomura, Kaori Saito, Keiko Kato, Yukinari Kato, Toshihiko Wakabayashi, Tomoyoshi Soga, Atsushi Natsume

    Tumor Biology     2014.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s13277-014-1784-5

  86. Current trends in targeted therapies for glioblastoma multiforme

    Fumiharu Ohka, Atsushi Natsume, Toshihiko Wakabayashi

    Neurology Research International     2012.3

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    DOI: 10.1155/2012/878425

  87. The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma Reviewed

    Fumiharu Ohka, Atsushi Natsume, Kazuya Motomura, Yugo Kishida, Yutaka Kondo, Tatsuya Abe, Yoko Nakasu, Hiroki Namba, Kenji Wakai, Takashi Fukui, Hiroyuki Momota, Kenichiro Iwami, Sayano Kinjo, Maki Ito, Masazumi Fujii, Toshihiko Wakabayashi

    PLoS ONE     2011.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0023332

▼display all

Books 1

  1. Epegenetic Cancer Therapy, CLINICAL SIGNIFICANCE OF EPIGENETIC ALTERATIONS IN GLIOBLASTOMA

    Ohka F, Natsume A, Kondo Y( Role: Joint author)

    ACADEMIC PRESS  2015 

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    Language:English

Presentations 2

  1. Role of Dysregulation of EZH2-H3K27me3 in Gliomagenesis

    Ohka F, Natsume A, Deguchi S, Katsushima K, Shinjo K, Wakabayashi T, Kondo Y

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    Event date: 2015.10

    Language:English   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

  2. 次世代型術中decision-makingのための術中分子診断法の確立

    大岡史治、栗本路弘、山道茜、鈴木啓道、青木恒介、近藤五郎、本村和也、若林俊彦、夏目敦至

    第20回日本脳腫瘍の外科学会 

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    Event date: 2015.9

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

Research Project for Joint Research, Competitive Funding, etc. 5

  1. 悪性脳腫瘍のオルガノイドモデルを用いた新規エピゲノム治療の探索

    2020.9

    武田科学振興財団医学系研究助成 

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    Grant type:Competitive

  2. G34R/V変異小児悪性神経膠腫の腫瘍形成メカニズムの解明

    2018 - 2019

    上原記念生命科学財団リサーチフェローシップ 

    大岡史治

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    Grant type:Competitive

  3. 小児毛様細胞性星細胞腫(Pilocytic astrocytoma)のLiquid biopsyを目指した、BRAF遺伝子異常の迅速高感度解析法の確立

    2017.4 - 2018.3

    日比野基金医学研究助成 

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    Grant type:Competitive

  4. 小児脳幹グリオーマのLiquid biopsyを目指したH3F3A遺伝子変異の高感度診断法の確立

    2017.4 - 2018.3

    日本脳神経財団研究助成 

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    Grant type:Competitive

  5. 高感度迅速遺伝子解析システムを用いた、liquid biopsyによる小児、若年成人脳腫瘍の新規低侵襲診断法の開発

    2017.4 - 2018.3

    共済団医学奨励研究助成 

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    Grant type:Competitive

KAKENHI (Grants-in-Aid for Scientific Research) 12

  1. オルガノイドモデルを用いた脳腫瘍の悪性転化を誘導する分子メカニズムの解明

    Grant number:23K08497  2023.4 - 2026.3

    科学研究費助成事業  基盤研究(C)

    大岡 史治, 本村 和也

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    Authorship:Principal investigator 

    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    近年のビッグデータにより、脳腫瘍には多彩なゲノム・エピゲノム異常が蓄積していることが明らかになった。今後脳腫瘍の新規治療戦略を開発するためには、マスターレギュレーターとして中心的な役割を果たす分子異常を同定することが重要である。本研究では脳腫瘍オルガノイドモデルのゲノム編集を行うことで組織学的な悪性転化が誘導されるモデルを作成する。本モデルを用いて経時的にゲノム・エピゲノム異常を解析することで、悪性転化においてマスターレギュレーターの役割を果たす分子異常を同定する。予後不良な脳腫瘍の未だ明らかになっていない重要な弱点を同定し、新規治療戦略の開発につながる研究になることを期待する。

  2. New molecular diagnostic technique for pituitary neuroendocrine tumors

    Grant number:23K08540  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Coinvestigator(s) 

  3. もやもや病脳動脈COL15A1発現低下のエピゲノム制御機構と病態生理の解明

    Grant number:22K09254  2022.4 - 2025.3

    科学研究費助成事業  基盤研究(C)

    荒木 芳生, 金森 史哲, 大岡 史治, 横山 欣也

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    研究代表者はこれまで、もやもや病病変部に対する網羅的遺伝子発現解析を行い、もやもや病患者では脳動脈に限局してCOL15A1遺伝子の低発現化が顕著であることを見出した。COL15A1蛋白は動脈組織の重要な構成成分であり、これまでの報告や病変の限局性からエピゲノム機序の存在が予想される。その低発現化は血管内皮や平滑筋細胞の変性、血管新生の促進など、もやもや病の様々な病態を矛盾なく説明し得ると考えた。今研究では、COL15A1遺伝子のエピゲノム制御機構と感受性遺伝子RNF213がそこに及ぼす影響を臨床検体を用いて、低発現となることで脳動脈に与える影響を細胞株や動物モデルを用いて明らかにする。
    もやもや病好発年齢、進行期である20歳以下の患者検体は、中高年以降の患者と比較して病変部動脈壁の菲薄化がさらに進行しており、western blotを行う上で十分量の蛋白が得られないと判断した。そこで2022年度は次世代シークエンシングを用いて、20歳未満の患者群、対照群についてトランスクリプトームを行うことで、病変部におけるCOL12A1の発現について検索を行うこととした。20歳以下のもやもや病患者を疾患群、焦点切除術を受けた難治性てんかん患者を対照群とした。脳表の動脈壁からtotal RNAを抽出し、NGSによるRNA-Seqを行った。データのマッピングと標準化ののち2群比較を行った。q-value<0.05かつ|Log2 fold change|>2のものをdifferentially expressed gene(DEG)とした。もやもや病10例、てんかん5例の比較に対しアッセイを行った。男女比と年齢分布は両群で一致させた。対照と比較し、もやもや病群では42遺伝子が高発現、144遺伝子が低発現、合計166遺伝子がDEGとなったが、CAL12A1はこれに含まれなかった。DEGsに対するエンリッチメント解析ではマトリソーム、細胞接着、血管新生に関連する遺伝子セットが有意に多く見られた。しかしながら特にもやもや病群において、次世代シークエンシングにおいてマッピング率が50%を下回るなど極端に低い値となっていた。開始total RNA量が微量であることが想定された。現在はこれまでのプロトコールよりもさらに微量の開始toral RNA量からライブラリ作成が可能なsingle cellを対象としたNGSライブラリ作成キットを用いたプロトコールを作成中である。
    特にもやもや病患者の病変部検体に含まれる蛋白やtotal RNA量が想定よりも微量であったことが原因と考えている。
    現在はこれまでのプロトコールよりもさらに微量の開始toral RNA量からライブラリ作成が可能なsingle cellを対象としたNGSライブラリ作成キットを用いたプロトコールを作成中である。

  4. The evolutional trajection and precision-medicine to gliomas

    Grant number:20H03789  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s) 

  5. Novel treatment strategy targeting neoantigen induced by epigenetic alterations in malignant glioma formation

    Grant number:19KK0228  2019.10 - 2023.3

    Grants-in-Aid for Scientific Research  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

    Natsume Atsushi

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    We have focused on a molecule named Podoplanin (PDPN) as a therapeutic target of malignant brain tumors. PDPN, a type I transmembrane mucin-like glycoprotein, is abundant in several solid tumors including squamous cell carcinoma, malignant mesothelioma, Kaposi sarcoma, angiosarcoma, testicular seminoma, and brain tumor. The expression level of PDPN is reported to be in accordance with tumor malignancy. We can relieve patients from suffering potential side effects if new measures are developed by which PDPN-expressing tumor cells are only killed.

  6. Aberrant chromatin remodeling induced by super-enhancer formation in malignant glioma

    Grant number:19K09478  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Ohka Fumiharu

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    Authorship:Principal investigator 

    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

    Despite the accumulation of big data, the mechanism of tumorigenesis of most malignant brain tumors is still unclear, and it is essential to explore novel mechanistic concepts that have never been explored before. Epigenomic mechanisms are precisely regulated by modifications that activate (on) and repress (off) gene expression, and an imbalance between these modification contributes to cancer development. Recently, super-enhancer formation has been proposed as a novel driver mechanism of cancer, in which transcription factors such as Myc molecules alter the three-dimensional structure of the genome and enhance gene expression of cancer-related genes. In this study, we will elucidate the abnormal chromatin conformational changes during tumor formation using a mouse model which spontaneously develops brain tumor.

  7. Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury

    Grant number:19K09453  2019.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Nishimura Yusuke

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    The transcriptome analysis of injured Xenopus laevis tadpole and mice suggested that Neurod4L.S., a basic-helix-loop-helix transcription factor, was the most promising transcription factor to exert neuroregeneration after spinal cord injury (SCI) in mammals. We generated a pseudotyped retroviral vector with the neurotropic lymphocytic choriomeningitis virus (LCMV) envelope to deliver murine Neurod4 to mice undergoing SCI. SCI induced ependymal cells to neural stem cells (NSCs) in the central canal. The LCMV envelope-based pseudotypedvector preferentially introduced Neurod4 into activated NSCs, which converted to neurons with axonal regrowth and suppressed the scar-forming glial lineage. Neurod4-induced inhibitory neurons predominantly projected to the subsynaptic domains of motor neurons at the epicenter, and Neurod4-induced excitatory neurons predominantly projected to subsynaptic domains of motor neurons caudal to the injury site suggesting the formation of functional synapses.

  8. スーパーエンハンサー形成が誘導する悪性脳腫瘍の異常クロマチンリモデリングの解明

    2019.4 - 2022.3

    科学研究費補助金  基盤研究(C)

    大岡 史治

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  9. Remodeling of altered epigenetic regulation via targeting epigenetic factor during glioma formation

    Grant number:16K20003  2016.4 - 2019.3

    Ohka Fumiharu

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    Authorship:Principal investigator 

    Grant amount:\3900000 ( Direct Cost: \3000000 、 Indirect Cost:\900000 )

    We established MADM mouse model which generates malignant glioma spontaneously. From an early stage of tumor formation, expression level of EZH2 was highly upregulated. Using glioma cell lines which are derived from MADM mice tumors, we found that EZH2 inhibitor (EPZ6438) inhibited cell growth of tumor cells. Also MRI imaging revealed that both oral administration of EPZ6438 and genetic depletion of EZH2 inhibited tumor growth in MADM mice significantly. We harvested tumor tissue of EZH2 knock-out MADM mice tumors, EZH2-intact MADM mice tumors and normal mice brains. Gene expression analysis with microarray revealed that expression levels of genes which are associated with neuronal differentiation are retained by knock out of EZH2 gene. These data indicated that EZH2 plays pivotal roles in glioma formation via dysregulation of histone modifications.

  10. エピゲノム修飾因子を標的とした悪性脳腫瘍の異常エピゲノムの修復

    2016.4 - 2018.3

    科学研究費補助金  若手研究(B)

    大岡 史治

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  11. 膠芽腫形成においてエピゲノム異常を誘導する新規分子の同定

    2014.4 - 2016.3

    科学研究費補助金  若手研究(B)

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  12. 悪性脳腫瘍におけるゲノムーエピゲノムのクロストークを標的とした新規治療の開発

    2014.4 - 2015.3

    科学研究費補助金 

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