Faculty Profiles - MATSUSHITA Masaki

Papers - MATSUSHITA Masaki

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Phase 1b study on the repurposing of meclizine hydrochloride for children with achondroplasia

Matsushita, M; Kitoh, H; Mishima, K; Kamiya, Y; Kato, D; Takemoto, G; Sawamura, K; Ueno, S; Yasuhiro, N; Nishida, K; Imagama, S

PLOS ONE Vol. 18 ( 7 ) page： e0283425 2023.7

Prognostic value of bone resorption pattern in the anterior portion of the femoral head in Legg-Calve-Perthes disease

Mishima, K; Kamiya, Y; Matsushita, M; Imagama, S

JOURNAL OF CHILDRENS ORTHOPAEDICS Vol. 17 ( 3 ) page： 197 - 204 2023.6

Activated FGFR3 suppresses bone regeneration and bone mineralization in an ovariectomized mouse model

Kawashima, I; Matsushita, M; Mishima, K; Kamiya, Y; Osawa, Y; Ohkawara, B; Ohno, K; Kitoh, H; Imagama, S

BMC MUSCULOSKELETAL DISORDERS Vol. 24 ( 1 ) page： 200 2023.3

Guided growth for coronal lower limb deformities in skeletal dysplasia

Kitoh, H; Kamiya, Y; Mishima, K; Matsushita, M; Kaneko, H; Kitamura, A; Sawamura, K; Matsuyama, S

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B Vol. 32 ( 2 ) page： 157 - 164 2023.3

Acute osteomyelitis of the patella due to Pseudomonas aeruginosa in an immunocompetent child: A case report

Kamiya, Y; Mishima, K; Tanaka, T; Sawamura, K; Matsushita, M; Imagama, S

MEDICINE Vol. 102 ( 7 ) page： e33012 2023.2

Meclozine ameliorates bone mineralization and growth plate structure in a mouse model of X-linked hypophosphatemia

Kamiya, Y; Matsushita, M; Mishima, K; Ohkawara, B; Michigami, T; Imagama, S; Ohno, K; Kitoh, H

EXPERIMENTAL AND THERAPEUTIC MEDICINE Vol. 25 ( 1 ) page： 39 2023.1

Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice

Kato, D; Matsushita, M; Takegami, Y; Mishima, K; Kamiya, N; Osawa, Y; Imagama, S; Kitoh, H

CALCIFIED TISSUE INTERNATIONAL Vol. 111 ( 6 ) page： 622 - 633 2022.12

A cross-sectional nationwide survey of osteosclerotic skeletal dysplasias in Japan

Sawamura, K; Mishima, K; Matsushita, M; Kamiya, Y; Kitoh, H

JOURNAL OF ORTHOPAEDIC SCIENCE Vol. 27 ( 5 ) page： 1139 - 1142 2022.9

Comparison of clinical outcomes, including the wound healing rate, between inframalleolar bypass to the pedal artery and that to the pedal branch artery in the modern endovascular era

Kodama Akio, Kobayashi Taira, Guntani Atsushi, Yamada Tetsuya, Koyama Akio, Mii Shinsuke, Ishibashi Hiroyuki, Matsushita Masahiro, Komori Kimihiro

JOURNAL OF VASCULAR SURGERY Vol. 75 ( 6 ) page： 2019 - + 2022.6

Bypass of Epiphyseal Fragmentation Following Early Salter Innominate Osteotomy and Its Clinical Relevance in Legg-Calve-Perthes Disease

Mishima, K; Kamiya, Y; Matsushita, M; Imagama, S; Kitoh, H

JOURNAL OF PEDIATRIC ORTHOPAEDICS Vol. 42 ( 5 ) page： 239 - 245 2022.5

Predictive ability of inflammatory markers and laboratory parameters in Legg-Calve-Perthes disease A single-center retrospective comparative study

Mishima, K; Kamiya, Y; Matsushita, M; Imagama, S; Kitoh, H

MEDICINE Vol. 101 ( 11 ) 2022.3

Disease-specific complications and multidisciplinary interventions in achondroplasia

Kitoh, H; Matsushita, M; Mishima, K; Kamiya, Y; Sawamura, K

JOURNAL OF BONE AND MINERAL METABOLISM Vol. 40 ( 2 ) page： 189 - 195 2022.3

Meclozine ameliorates skeletal muscle pathology and increases muscle forces in mdx mice

Kawamura, Y; Hida, T; Ohkawara, B; Matsushita, M; Kobayashi, T; Ishizuka, S; Hiraiwa, H; Tanaka, S; Tsushima, M; Nakashima, H; Ito, K; Imagama, S; Ito, M; Masuda, A; Ishiguro, N; Ohno, K

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Vol. 592 page： 87 - 92 2022.2

Meclozine Attenuates the MARK Pathway in Mammalian Chondrocytes and Ameliorates FGF2-Induced Bone Hyperossification in Larval Zebrafish

Takemoto, G; Matsushita, M; Okamoto, T; Ito, T; Matsuura, Y; Takashima, C; Chen-Yoshikawa, TF; Ebi, H; Imagama, S; Kitoh, H; Ohno, K; Hosono, Y

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY Vol. 9 page： 694018 2022.1

Inconvenience and adaptation in Japanese adult achondroplasia and hypochondroplasia: A cross-sectional study

Ajimi Akiko, Matsushita Masaki, Mishima Kenichi, Haga Nobuhiko, Fujiwara Sayaka, Ozono Keiichi, Kubota Takuo, Kitaoka Taichi, Imagama Shiro, Kitoh Hiroshi

CLINICAL PEDIATRIC ENDOCRINOLOGY Vol. 31 ( 1 ) page： 18 - 24 2022.1

Inconvenience and adaptation in Japanese adult achondroplasia and hypochondroplasia: A cross-sectional study.

Ajimi A, Matsushita M, Mishima K, Haga N, Fujiwara S, Ozono K, Kubota T, Kitaoka T, Imagama S, Kitoh H

Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology Vol. 31 ( 1 ) page： 18 - 24 2022

Asfotase alfa has a limited effect in improving the bowed limbs in perinatal benign hypophosphatasia: A case report

Matsushita, M; Mishima, K; Nagata, T; Kamiya, Y; Imagama, S; Kitoh, H

CLINICAL PEDIATRIC ENDOCRINOLOGY Vol. 30 ( 1 ) page： 53 - 56 2021.1

Health-related Quality of Life in Adult Patients with Multiple Epiphyseal Dysplasia and Spondyloepiphyseal Dysplasia.

Matsushita M, Mishima K, Kamiya Y, Haga N, Fujiwara S, Ozono K, Kubota T, Kitaoka T, Imagama S, Kitoh H

Progress in rehabilitation medicine Vol. 6 page： 20210048 2021

Effect of periosteal resection on longitudinal bone growth in a mouse model of achondroplasia

Kaneko, S; Matsushita, M; Mishima, K; Takegami, Y; Imagama, S; Kitoh, H

BONE REPORTS Vol. 13 page： 100708 2020.12

Legg-Calve-Perthes disease in a patient with Bardet-Biedl syndrome: A case report of a novel MKKS/BBS6 mutation

Mishima, K; Fujita, A; Mizuno, S; Matsushita, M; Nagata, T; Kamiya, Y; Miyake, N; Matsumoto, N; Imagama, S; Kitoh, H

CLINICAL CASE REPORTS Vol. 8 ( 12 ) page： 3109 - 3114 2020.12

Comparison of surgical and nonsurgical containment methods for patients with Legg-Calve-Perthes disease of the onset ages between 6.0 and 8.0 years: Salter osteotomy versus a non-weight-bearing hip flexion-abduction brace

Kaneko, H; Kitoh, H; Mishima, K; Matsushita, M; Hattori, T; Noritake, K; Ishiguro, N; Yoshihashi, Y

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B Vol. 29 ( 6 ) page： 542 - 549 2020.11

A retrospective comparative study of corrective osteotomy for tibial deformities with the multiaxial correction fixator and the circular fixator.

Matsushita M, Kitoh H, Mishima K, Nagata T, Kamiya Y, Kaneko H, Hattori T, Ishiguro N

Journal of clinical orthopaedics and trauma Vol. 11 ( Suppl 4 ) page： S621 - S625 2020.7

Lower limb pain following allogeneic hematopoietic stem cell transplantation in Japanese children

Mishima, K; Kitoh, H; Matsushita, M; Nagata, T; Kamiya, Y; Takahashi, Y; Ishiguro, N

JOURNAL OF ORTHOPAEDIC SCIENCE Vol. 25 ( 4 ) page： 682 - 687 2020.7

Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

Kitoh, H; Matsushita, M; Mishima, K; Nagata, T; Kamiya, Y; Ueda, K; Kuwatsuka, Y; Morikawa, H; Nakai, Y; Ishiguro, N

PLOS ONE Vol. 15 ( 4 ) page： e0229639 2020.4

Severe achondroplasia due to two de novo variants in the transmembrane domain of FGFR3 on the same allele: A case report

Nagata, T; Matsushita, M; Mishima, K; Kamiya, Y; Kato, K; Toyama, M; Ogi, T; Ishiguro, N; Kitoh, H

MOLECULAR GENETICS & GENOMIC MEDICINE Vol. 8 ( 3 ) page： e1148 2020.3

Impact of fracture characteristics and disease-specific complications on health-related quality of life in osteogenesis imperfecta

Matsushita, M; Mishima, K; Yamashita, S; Haga, N; Fujiwara, S; Ozono, K; Kubota, T; Kitaoka, T; Ishiguro, N; Kitoh, H

JOURNAL OF BONE AND MINERAL METABOLISM Vol. 38 ( 1 ) page： 109 - 116 2020.1

Physical, Mental, and Social Problems of Adolescent and Adult Patients with Achondroplasia

Matsushita, M; Kitoh, H; Mishima, K; Yamashita, S; Haga, N; Fujiwara, S; Ozono, K; Kubota, T; Kitaoka, T; Ishiguro, N

CALCIFIED TISSUE INTERNATIONAL Vol. 104 ( 4 ) page： 364 - 372 2019.4

Early radiographic risk factors for rigid relapse in idiopathic clubfoot treated with the Ponseti method.

Mishima K, Kitoh H, Matsushita M, Sugiura H, Hasegawa S, Kitamura A, Nishida Y, Ishiguro N

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons Vol. 24 ( 6 ) page： 509 - 513 2018.12

Changes in the range of motion of the lower limb joints during extensive tibial lengthening in achondroplasia

Kadono Izumi, Kitoh Hiroshi, Mishima Kenichi, Matsushita Masaki, Sato Koji, Kako Masato, Ishiguro Naoki

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B Vol. 27 ( 6 ) page： 535 - 540 2018.11

A Mouse Distraction Osteogenesis Model

Fujio Masahito, Osawa Yusuke, Matsushita Masaki, Ogisu Kota, Tsuchiya Shuhei, Kitoh Hiroshi, Hibi Hideharu

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS ( 141 ) 2018.11

Long term health-related quality of life in patients with achondroplasia and hypochondroplasia

Matsushita, M; Kitoh, H; Mishima, K; Ishiguro, N; Fujiwara, S; Haga, N; Kitaoka, T; Kubota, T; Ozono, K

JOURNAL OF BONE AND MINERAL RESEARCH Vol. 33 page： 300 - 301 2018.11

Activated FGFR3 prevents subchondral bone sclerosis during the development of osteoarthritis in transgenic mice with achondroplasia.

Okura T, Matsushita M, Mishima K, Esaki R, Seki T, Ishiguro N, Kitoh H

Journal of orthopaedic research : official publication of the Orthopaedic Research Society Vol. 36 ( 1 ) page： 300 - 308 2018.1

Chronic lateral epiphyseal separation of the proximal tibia causes late-onset tibia vara.

Hasegawa S, Kitoh H, Matsushita M, Mishima K, Kadono I, Sugiura H, Kitamura A, Ishiguro N

Journal of pediatric orthopedics. Part B Vol. 27 ( 1 ) page： 31 - 34 2018.1

A Novel Heterozygous Mutation in the T-box Protein 4 Gene in an Adult Case of Small Patella Syndrome.

Oda T, Matsushita M, Ono Y, Kitoh H, Sakai T

Journal of orthopaedic case reports Vol. 8 ( 1 ) page： 85 - 88 2018.1

Extensive Bone Lengthening for a Patient with Linear Morphea.

Mishima K, Kitoh H, Matsushita M, Nagata T, Kamiya Y, Ishiguro N

Case reports in orthopedics Vol. 2018 page： 4535804 2018

Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis

Osawa Yusuke, Matsushita Masaki, Hasegawa Sachi, Esaki Ryusaku, Fujio Masahito, Ohkawara Bisei, Ishiguro Naoki, Ohno Kinji, Kitoh Hiroshi

BONE Vol. 105 page： 42 - 49 2017.12

Activated FGFR3 Prevents Subchondral Bone Sclerosis During the Development of Osteoarthritis in Transgenic Mice with Achondroplasia.

Okura, T; Matsushita, M; Mishima, K; Seki, T; Ishiguro, N; Kitoh, H

JOURNAL OF BONE AND MINERAL RESEARCH Vol. 32 page： S201 - S201 2017.12

Clinical dosage of meclozine promotes longitudinal bone growth, bone volume, and trabecular bone quality in transgenic mice with achondroplasia

Matsushita Masaki, Esaki Ryusaku, Mishima Kenichi, Ishiguro Naoki, Ohno Kinji, Kitoh Hiroshi

SCIENTIFIC REPORTS Vol. 7 ( 1 ) page： 7371 2017.8

Percutaneous pinning after prolonged skeletal traction with the hip in a flexed position for unstable slipped capital femoral epiphysis A case series of 11 patients

Matsushita Masaki, Mishima Kenichi, Iwata Kohji, Hattori Tadashi, Ishiguro Naoki, Kitoh Hiroshi

MEDICINE Vol. 96 ( 19 ) page： e6662 2017.5

Is the timing of surgery associated with avascular necrosis after unstable slipped capital femoral epiphysis? A multicenter study.

Kohno Yusuke, Nakashima Yasuharu, Kitano Toshio, Irie Taichi, Kita Atsushi, Nakamura Tomoyuki, Endo Hirosuke, Fujii Yosuke, Kuroda Takayuki, Mitani Shigeru, Kitoh Hiroshi, Matsushita Masaki, Hattori Tadashi, Iwata Koji, Iwamoto Yukihide

JOURNAL OF ORTHOPAEDIC SCIENCE Vol. 22 ( 1 ) page： 112 - 115 2017.1

Maternal administration of meclozine for the treatment of foramen magnum stenosis in transgenic mice with achondroplasia

Matsushita Masaki, Mishima Kenichi, Esaki Ryusaku, Ishiguro Naoki, Ohno Kinji, Kitoh Hiroshi

JOURNAL OF NEUROSURGERY-PEDIATRICS Vol. 19 ( 1 ) page： 91 - 95 2017.1

Maternal administration of meclozine for the treatment of foramen magnum stenosis in transgenic mice with achondroplasia

Matsushita M, Mishima K, Esaki R, Ishiguro N, Ohno K, Kitoh H

J Neurosurg Pediatr Vol. 19 page： 91-95 2017

[Risk factors for rebleeding and risk-based follow-up of obscure gastrointestinal bleeding after its initial diagnosis].

Uchida G, Nakamura M, Watanabe O, Yamamura T, Matsushita M, Ishikawa T, Furukawa K, Funasaka K, Ohno E, Kawashima H, Miyahara R, Goto H, Hirooka Y

Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology Vol. 114 ( 10 ) page： 1819 - 1829 2017

Clinical Results and Complications of Lower Limb Lengthening for Fibular Hemimelia: A Report of Eight Cases. Invited Reviewed

Mishima K, Kitoh H, Iwata K, Matsushita M, Nishida Y, Hattori T, Ishiguro N

Medicine (Baltimore) Vol. 95 ( 21 ) page： e3787 2016.5

Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters Invited Reviewed

Hasegawa S, Kitoh H, Ohkawara B, Mishima K, Matsushita M, Masuda A, Ishiguro N, Ohno K

Biochem Biophys Res Commun Vol. 470 ( 2 ) page： 356 - 361 2016.2

Characterisation of novel RUNX2 mutation with alanine tract expansion from Japanese cleidocranial dysplasia patient Invited Reviewed

Shibata A, Machida J, Yamaguchi S, Kimura M, Tatematsu T, Miyachi H, Matsushita M, Kitoh H, Ishiguro N, Nakayama A, Higashi Y, Shimozato K, Tokita Y

Mutagenesis Vol. 31 ( 1 ) page： 61 - 67 2016.1

Low bone mineral density in achondroplasia and hypochondroplasia Reviewed

Matsushita M, Kitoh H, Mishima K, Kadono I, Sugiura H, Hasegawa S, Nishida Y, Ishiguro N

Pediatr Int page： 10.1111/ped.12890 2016

Prediction of Clinically Significant Leg-Length Discrepancy in Congenital Disorders Invited Reviewed

Mishima K, Kitoh H, Kadono I, Matsushita M, Sugiura H, Hasegawa S, Kitamura A, Nishida Y, Ishiguro N

Orthopedics Vol. 38 ( 10 ) page： e919 - e924 2015.10

Meclozine promotes lomgitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene Reviewed

Matsushita M, Hasegawa S, Kitoh H, Mori K, Ohkawara B, Yasoda A, Masuda A, Ishiguro N, Ohno K

Endocrinology Vol. 156 page： 548-554 2015

A glutamine repeat variant of the RUNX2 gene causes cleidocranial dysplasia Reviewed

Matsushita M, Kitoh H, Subasioglu A, Colak FK, Dundar M, Mishima K, Nishida Y, Ishiguro N

Mol Syndromol page： in press 2015

Factors associated with an unfavourable outcome after Salter innominate osteotomy in patients with unilateral developmental dysplasia of the hip: Does occult dysplasia of the contralateral hip affect the outcome? Invited Reviewed

Kaneko H, Kitoh H, Mishima K, Matsushita M, Kadono I, Ishiguro N, Hattori T

Bone Joint J Vol. 96-B ( 10 ) page： 1419 - 1423 2014.10

Early and late fracture following extensive limb lengthening in achondroplasia and hypochondroplasia Invited Reviewed

Kitoh H, Kaneko H, Mishima K, Matsushita M, Kadono I, Nishida Y, Ishiguro N

Bone Joint J Vol. 96-B ( 9 ) page： 1269 - 1273 2014.9

Radiographic characteristics of the hand and cervical spine in fibrodysplasia ossificans progressiva Invited Reviewed

Mishima K, Kitoh H, Haga N, Nakashima Y, Kamizono J, Katagiri T, Susami T, Matsushita M, Ishiguro N

Intractable Rare Dis Res Vol. 3 ( 2 ) page： 46 - 51 2014.5

A case of severe proximal focal femoral deficiency with overlapping phenotypes of Al-Awadi-Raas-Rothschild syndrome and Fuhrmann syndrome Reviewed

Matsushita M, Kitoh H, Mishima K, Nishida Y, Ishiguro N

Ped Radiol Vol. 44 page： 1617-1619 2014

Benign prenatal hypophosphatasia: a treatable disease not to be missed Reviewed

Matsushita M, Kitoh H, Michigami T, Tachikawa K, Kaneko H, Mishima K, Ishiguro N

Ped Radiol Vol. 44 page： 340-343 2014

A novel in-flame deletion of the RUNX2 gene causes a classic form of cleidocranial dysplasia Reviewed

Matsushita M, Kitoh H, Kaneko H, Mishima K, Itoh Y, Tokita Y, Ishiguro N

J Bone Miner Metab Vol. 32 page： 96-99 2014

A comparative study of blade plate fixation and external fixation in osteotomies for slipped capital femoral epiphysis Invited Reviewed

Kitoh H, Kitakoji T, Hattori T, Kaneko H, Mishima K, Matsushita M, Ishiguro N

J Pediatr Orthop B Vol. 22 ( 6 ) page： 542 - 547 2013.11

Perhexiline maleate in the treatment of fibrodysplasia ossificans progressiva: an open-labeled clinical trial Invited Reviewed

Kitoh H, Achiwa M, Kaneko H, Mishima K, Matsushita M, Kadono I, Horowitz JD, Sallustio BC, Ohno K, Ishiguro N

Orphanet J Rare Dis Vol. 8 page： 163 2013.10

Long-term outcome of gradual reduction using overhead traction for developmental dysplasia of the hip over 6 months of age Invited Reviewed

Kaneko H, Kitoh H, Mishima K, Matsushita M, Ishiguro N

J Pediatr Orthop Vol. 33 ( 6 ) page： 628 - 634 2013.9

Prognostic factors for trochanteric overgrowth after containment treatment in Legg-Calvé-Perthes disease Invited Reviewed

Kitoh H, Kaneko H, Mishima K, Matsushita M, Ishiguro N

J Pediatr Orthop B Vol. 22 ( 5 ) page： 432 - 436 2013.9

Clinically applicable antianginal agents suppress osteoblastic transformation of myogenic cells and heterotopic ossifications in mice Invited Reviewed

Yamamoto R, Matsushita M, Kitoh H, Masuda A, Ito M, Katagiri T, Kawai T, Ishiguro N, Ohno K

J Bone Miner Metab Vol. 31 ( 1 ) page： 26 - 33 2013.1

Orthopaedic manifestations and diagnostic clues in children with Guillain-Barré syndrome Reviewed

Matsushita M, Kitoh H, Itomi K, Kitakoji T, Iwata K, Mishima K, Ishiguro N, Hattori T

J Child Orthop Vol. 7 page： 177-182 2013

Meclozine facilitates chondrocyte proliferation and differentiation by attenuating abnormally activated fibroblast growth factor receptor 3 (FGFR3) signaling in achondroplasia Reviewed

Matsushita M, Kitoh H, Ohkawara B, Mishima K, Kaneko H, Ito M, Masuda A, Ishiguro N, Ohno K

PLoS One Vol. 8 page： e81569 2013

A novel SOX9 H169Q mutation in a family with overlapping phenotype of mild campomelic dysplasia and small patella syndrome Reviewed

Matsushita M, Kitoh H, Kaneko H, Mishima K, Kadono I, Ishiguro N, Nishmura G

Am J Med Genet A Vol. 161 page： 2528-2534 2013

Isolated bifid rib: clinical and radiological findings in children Invited Reviewed

Kaneko H, Kitoh H, Mabuchi A, Mishima K, Matsushita M, Ishiguro N

Pediatr Int Vol. 54 ( 6 ) page： 820 - 823 2012.12

Novel compound heterozygous mutations in the cathepsin K gene in Japanese female siblings with pyknodysostosis Reviewed

Matsushita M, Kitoh H, Kaneko H, Mishima K, Itoh Y, Hattori T, Ishiguro N

Mol Syndromol Vol. 2 page： 254-258 2012

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Papers - MATSUSHITA Masaki