Faculty Profiles - MISHIMA Kenichi

Papers - MISHIMA Kenichi

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Comparing short vs. intermediate and long nails in elderly patients with unstable multifragmental femoral trochanteric fractures (AO type A2): Multicenter (TRON group) retrospective study.

Tsugeno H, Takegami Y, Tokutake K, Mishima K, Nakashima H, Kobayashi K, Imagama S

Injury Vol. 55 ( 4 ) page： 111420 2024.2

Early versus delayed weight bearing after internal fixation for femoral neck fracture in younger adults: A multicenter retrospective study

Hasegawa, K; Takegami, Y; Tokutake, K; Nakashima, H; Mishima, K; Kobayashi, K; Imagama, S

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED Vol. 55 ( 2 ) page： 111292 2024.2

Phase 1b study on the repurposing of meclizine hydrochloride for children with achondroplasia

Matsushita, M; Kitoh, H; Mishima, K; Kamiya, Y; Kato, D; Takemoto, G; Sawamura, K; Ueno, S; Yasuhiro, N; Nishida, K; Imagama, S

PLOS ONE Vol. 18 ( 7 ) page： e0283425 2023.7

Prognostic value of bone resorption pattern in the anterior portion of the femoral head in Legg-Calve-Perthes disease

Mishima, K; Kamiya, Y; Matsushita, M; Imagama, S

JOURNAL OF CHILDRENS ORTHOPAEDICS Vol. 17 ( 3 ) page： 197 - 204 2023.6

Activated FGFR3 suppresses bone regeneration and bone mineralization in an ovariectomized mouse model

Kawashima, I; Matsushita, M; Mishima, K; Kamiya, Y; Osawa, Y; Ohkawara, B; Ohno, K; Kitoh, H; Imagama, S

BMC MUSCULOSKELETAL DISORDERS Vol. 24 ( 1 ) page： 200 2023.3

Guided growth for coronal lower limb deformities in skeletal dysplasia

Kitoh, H; Kamiya, Y; Mishima, K; Matsushita, M; Kaneko, H; Kitamura, A; Sawamura, K; Matsuyama, S

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B Vol. 32 ( 2 ) page： 157 - 164 2023.3

Acute osteomyelitis of the patella due to Pseudomonas aeruginosa in an immunocompetent child: A case report

Kamiya, Y; Mishima, K; Tanaka, T; Sawamura, K; Matsushita, M; Imagama, S

MEDICINE Vol. 102 ( 7 ) page： e33012 2023.2

Meclozine ameliorates bone mineralization and growth plate structure in a mouse model of X-linked hypophosphatemia

Kamiya, Y; Matsushita, M; Mishima, K; Ohkawara, B; Michigami, T; Imagama, S; Ohno, K; Kitoh, H

EXPERIMENTAL AND THERAPEUTIC MEDICINE Vol. 25 ( 1 ) page： 39 2023.1

Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice

Kato, D; Matsushita, M; Takegami, Y; Mishima, K; Kamiya, N; Osawa, Y; Imagama, S; Kitoh, H

CALCIFIED TISSUE INTERNATIONAL Vol. 111 ( 6 ) page： 622 - 633 2022.12

Efficacy of soluble lansoprazole-impregnated beta-tricalcium phosphate for bone regeneration

Mishima, K; Okabe, YT; Mizuno, M; Ohno, K; Kitoh, H; Imagama, S

SCIENTIFIC REPORTS Vol. 12 ( 1 ) page： 20550 2022.11

A cross-sectional nationwide survey of osteosclerotic skeletal dysplasias in Japan

Sawamura, K; Mishima, K; Matsushita, M; Kamiya, Y; Kitoh, H

JOURNAL OF ORTHOPAEDIC SCIENCE Vol. 27 ( 5 ) page： 1139 - 1142 2022.9

Bypass of Epiphyseal Fragmentation Following Early Salter Innominate Osteotomy and Its Clinical Relevance in Legg-Calvé-Perthes Disease. Reviewed

Mishima K, Kamiya Y, Matsushita M, Imagama S, Kitoh H.

J Pediatric Orthopaedics Vol. 42 ( 5 ) page： 239 - 245 2022.5

Bypass of Epiphyseal Fragmentation Following Early Salter Innominate Osteotomy and Its Clinical Relevance in Legg-Calve-Perthes Disease

Mishima, K; Kamiya, Y; Matsushita, M; Imagama, S; Kitoh, H

JOURNAL OF PEDIATRIC ORTHOPAEDICS Vol. 42 ( 5 ) page： 239 - 245 2022.5

Predictive ability of inflammatory markers and laboratory parameters in Legg-Calve-Perthes disease A single-center retrospective comparative study

Mishima, K; Kamiya, Y; Matsushita, M; Imagama, S; Kitoh, H

MEDICINE Vol. 101 ( 11 ) 2022.3

Disease-specific complications and multidisciplinary interventions in achondroplasia

Kitoh, H; Matsushita, M; Mishima, K; Kamiya, Y; Sawamura, K

JOURNAL OF BONE AND MINERAL METABOLISM Vol. 40 ( 2 ) page： 189 - 195 2022.3

Inconvenience and adaptation in Japanese adult achondroplasia and hypochondroplasia: A cross-sectional study

Ajimi, A; Matsushita, M; Mishima, K; Haga, N; Fujiwara, S; Ozono, K; Kubota, T; Kitaoka, T; Imagama, S; Kitoh, H

CLINICAL PEDIATRIC ENDOCRINOLOGY Vol. 31 ( 1 ) page： 18 - 24 2022.1

ペルテス病を発症したBardet-Biedl症候群の1例 Reviewed

三島　健一、神谷　庸成、松下　雅樹、今釜　史郎、鬼頭　浩史

日本整形外科学会雑誌 Vol. 95 ( 11 ) page： 1068 - 1071 2021.11

Asfotase alfa has a limited effect in improving the bowed limbs in perinatal benign hypophosphatasia: A case report

Matsushita, M; Mishima, K; Nagata, T; Kamiya, Y; Imagama, S; Kitoh, H

CLINICAL PEDIATRIC ENDOCRINOLOGY Vol. 30 ( 1 ) page： 53 - 56 2021.1

Salter-Harris分類V型の骨端線損傷による外反膝変形をTL-HEXシステムで矯正した１例 Invited Reviewed

三島　健一、神谷　庸成、松下　雅樹、今釜　史郎

中部日本整形外科災害外科学会誌 2021

Health-related Quality of Life in Adult Patients with Multiple Epiphyseal Dysplasia and Spondyloepiphyseal Dysplasia.

Matsushita M, Mishima K, Kamiya Y, Haga N, Fujiwara S, Ozono K, Kubota T, Kitaoka T, Imagama S, Kitoh H

Progress in rehabilitation medicine Vol. 6 page： 20210048 2021

ペルテス病における血液検査所見と予後因子との関連 Reviewed

三島　健一、神谷　庸成、松下　雅樹、今釜　史郎

日本小児整形外科学会雑誌 Vol. 30 ( 2 ) page： 13 - 17 2021

Legg-Calve-Perthes disease in a patient with Bardet-Biedl syndrome: A case report of a novel MKKS/BBS6 mutation

Mishima, K; Fujita, A; Mizuno, S; Matsushita, M; Nagata, T; Kamiya, Y; Miyake, N; Matsumoto, N; Imagama, S; Kitoh, H

CLINICAL CASE REPORTS Vol. 8 ( 12 ) page： 3109 - 3114 2020.12

Scoliosis Caused by Limb-Length Discrepancy in Children

Kobayashi, K; Ando, K; Nakashima, H; Machino, M; Morozumi, M; Kanbara, S; Ito, S; Inoue, T; Yamaguchi, H; Mishima, K; Ishiguro, N; Imagama, S

ASIAN SPINE JOURNAL Vol. 14 ( 6 ) page： 801 - 807 2020.12

Effect of periosteal resection on longitudinal bone growth in a mouse model of achondroplasia

Kaneko, S; Matsushita, M; Mishima, K; Takegami, Y; Imagama, S; Kitoh, H

BONE REPORTS Vol. 13 page： 100708 2020.12

Comparison of surgical and nonsurgical containment methods for patients with Legg-Calve-Perthes disease of the onset ages between 6.0 and 8.0 years: Salter osteotomy versus a non-weight-bearing hip flexion-abduction brace

Kaneko, H; Kitoh, H; Mishima, K; Matsushita, M; Hattori, T; Noritake, K; Ishiguro, N; Yoshihashi, Y

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B Vol. 29 ( 6 ) page： 542 - 549 2020.11

Lower limb pain following allogeneic hematopoietic stem cell transplantation in Japanese children

Mishima, K; Kitoh, H; Matsushita, M; Nagata, T; Kamiya, Y; Takahashi, Y; Ishiguro, N

JOURNAL OF ORTHOPAEDIC SCIENCE Vol. 25 ( 4 ) page： 682 - 687 2020.7

A retrospective comparative study of corrective osteotomy for tibial deformities with the multiaxial correction fixator and the circular fixator.

Matsushita M, Kitoh H, Mishima K, Nagata T, Kamiya Y, Kaneko H, Hattori T, Ishiguro N

Journal of clinical orthopaedics and trauma Vol. 11 ( Suppl 4 ) page： S621 - S625 2020.7

Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia

Kitoh, H; Matsushita, M; Mishima, K; Nagata, T; Kamiya, Y; Ueda, K; Kuwatsuka, Y; Morikawa, H; Nakai, Y; Ishiguro, N

PLOS ONE Vol. 15 ( 4 ) page： e0229639 2020.4

Severe achondroplasia due to two de novo variants in the transmembrane domain of FGFR3 on the same allele: A case report

Nagata, T; Matsushita, M; Mishima, K; Kamiya, Y; Kato, K; Toyama, M; Ogi, T; Ishiguro, N; Kitoh, H

MOLECULAR GENETICS & GENOMIC MEDICINE Vol. 8 ( 3 ) page： e1148 2020.3

Impact of fracture characteristics and disease-specific complications on health-related quality of life in osteogenesis imperfecta

Matsushita, M; Mishima, K; Yamashita, S; Haga, N; Fujiwara, S; Ozono, K; Kubota, T; Kitaoka, T; Ishiguro, N; Kitoh, H

JOURNAL OF BONE AND MINERAL METABOLISM Vol. 38 ( 1 ) page： 109 - 116 2020.1

Physical, Mental, and Social Problems of Adolescent and Adult Patients with Achondroplasia

Matsushita, M; Kitoh, H; Mishima, K; Yamashita, S; Haga, N; Fujiwara, S; Ozono, K; Kubota, T; Kitaoka, T; Ishiguro, N

CALCIFIED TISSUE INTERNATIONAL Vol. 104 ( 4 ) page： 364 - 372 2019.4

Early radiographic risk factors for rigid relapse in idiopathic clubfoot treated with the Ponseti method.

Mishima K, Kitoh H, Matsushita M, Sugiura H, Hasegawa S, Kitamura A, Nishida Y, Ishiguro N

Foot and ankle surgery : official journal of the European Society of Foot and Ankle Surgeons Vol. 24 ( 6 ) page： 509 - 513 2018.12

Changes in the range of motion of the lower limb joints during extensive tibial lengthening in achondroplasia.

Kadono I, Kitoh H, Mishima K, Matsushita M, Sato K, Kako M, Ishiguro N

Journal of pediatric orthopedics. Part B Vol. 27 ( 6 ) page： 535 - 540 2018.11

Long term health-related quality of life in patients with achondroplasia and hypochondroplasia

Matsushita, M; Kitoh, H; Mishima, K; Ishiguro, N; Fujiwara, S; Haga, N; Kitaoka, T; Kubota, T; Ozono, K

JOURNAL OF BONE AND MINERAL RESEARCH Vol. 33 page： 300 - 301 2018.11

Activated FGFR3 prevents subchondral bone sclerosis during the development of osteoarthritis in transgenic mice with achondroplasia

Okura Toshiaki, Matsushita Masaki, Mishima Kenichi, Esaki Ryusaku, Seki Taisuke, Ishiguro Naoki, Kitoh Hiroshi

JOURNAL OF ORTHOPAEDIC RESEARCH Vol. 36 ( 1 ) page： 300 - 308 2018.1

Chronic lateral epiphyseal separation of the proximal tibia causes late-onset tibia vara

Hasegawa Sachi, Kitoh Hiroshi, Matsushita Masaki, Mishima Kenichi, Kadono Izumi, Sugiura Hiroshi, Kitamura Akiko, Ishiguro Naoki

JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B Vol. 27 ( 1 ) page： 31 - 34 2018.1

Extensive Bone Lengthening for a Patient with Linear Morphea.

Mishima K, Kitoh H, Matsushita M, Nagata T, Kamiya Y, Ishiguro N

Case reports in orthopedics Vol. 2018 page： 4535804 2018

脚長差に伴う機能性側弯の特徴 Invited Reviewed

三島健一、鬼頭　浩史、松下　雅樹、門野　泉、長田侃、西田　佳弘、石黒　直樹

日本小児整形外科学会雑誌 2018

Activated FGFR3 Prevents Subchondral Bone Sclerosis During the Development of Osteoarthritis in Transgenic Mice with Achondroplasia.

Okura Toshiaki, Matsushita Masaki, Mishima Kenichi, Seki Taisuke, Ishiguro Naoki, Kitoh Hiroshi

JOURNAL OF BONE AND MINERAL RESEARCH Vol. 32 page： S201 - S201 2017.12

Clinical dosage of meclozine promotes longitudinal bone growth, bone volume, and trabecular bone quality in transgenic mice with achondroplasia

Matsushita Masaki, Esaki Ryusaku, Mishima Kenichi, Ishiguro Naoki, Ohno Kinji, Kitoh Hiroshi

SCIENTIFIC REPORTS Vol. 7 ( 1 ) page： 7371 2017.8

Percutaneous pinning after prolonged skeletal traction with the hip in a flexed position for unstable slipped capital femoral epiphysis A case series of 11 patients

Matsushita Masaki, Mishima Kenichi, Iwata Kohji, Hattori Tadashi, Ishiguro Naoki, Kitoh Hiroshi

MEDICINE Vol. 96 ( 19 ) page： e6662 2017.5

Maternal administration of meclozine for the treatment of foramen magnum stenosis in transgenic mice with achondroplasia

Matsushita Masaki, Mishima Kenichi, Esaki Ryusaku, Ishiguro Naoki, Ohno Kinji, Kitoh Hiroshi

JOURNAL OF NEUROSURGERY-PEDIATRICS Vol. 19 ( 1 ) page： 91 - 95 2017.1

小児同種造血幹細胞移植後の下肢痛症例の検討 Invited Reviewed

三島健一、鬼頭浩史、松下雅樹、門野　泉、杉浦　洋、北村暁子、西田　佳弘、石黒　直樹

日本小児整形外科学会雑誌 2017

Clinical Results and Complications of Lower Limb Lengthening for Fibular Hemimelia: A Report of Eight Cases. Reviewed

Mishima K, Kitoh H, Iwata K, Matsushita M, Nishida Y, Hattori T, Ishiguro N.

Medicine (Baltimore) Vol. 95 ( 21 ) page： e3787 2016.5

Low bone mineral density in achondroplasia and hypochondroplasia. Reviewed

Matsushita M, Kitoh H, Mishima K, Kadono I, Sugiura H, Hasegawa S, Nishida Y, Ishiguro N.

Pediatr Int. Vol. 58 ( 8 ) page： 705 - 708 2016.4

Ponseti法におけるX線学的予後予測因子 Invited Reviewed

三島健一、鬼頭浩史、松下雅樹、門野　泉、杉浦　洋、長谷川幸、北村暁子、西田　佳弘、石黒　直樹

日本小児整形外科学会雑誌 2016

Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis Reviewed

Mishima K, Kitoh H, Ohkawara B, Okuno T, Ito M, Masuda A, Ishiguro N, Ohno K.

EBioMedicine Vol. 2 ( 12 ) page： 2046-2061 2015.11

Prediction of Clinically Significant Leg-Length Discrepancy in Congenital Disorders Reviewed

Kenichi Mishima, Hiroshi Kitoh, Izumi Kadono, Masaki Matsushita, Hiroshi Sugiura, Sachi Hasegawa, Akiko Kitamura, Yoshihiro Nishida, Naoki Ishiguro

ORTHOPEDICS Vol. 38 ( 10 ) page： e919-e924 2015.10

腓骨列形成不全症9例に対する骨延長術の治療成績 Invited Reviewed

三島健一, 鬼頭浩史, 松下雅樹, 長谷川幸, 服部義, 金子浩史, 岩田浩志, 北村暁子

日本創外固定・骨延長学会雑誌 2015

Ponseti法における初期治療の重要性 Invited Reviewed

三島健一、鬼頭浩史、門野　泉、松下雅樹、杉浦　洋、長谷川幸、北村暁子、西田　佳弘、石黒　直樹

日本小児整形外科学会雑誌 2015

Radiographic characteristics of the hand and cervical spine in fibrodysplasia ossificans progressiva. Reviewed

Mishima K, Kitoh H, Haga N, Nakashima Y, Kamizono J, Katagiri T, Susami T, Matsushita M, Ishiguro N.

Intractable Rare Dis Res. page： 46-51 2014.5

A case of severe proximal focal femoral deficiency with overlapping phenotypes of Al-Awadi-Raas-Rothschild syndrome and Fuhrmann syndrome. Reviewed

Matsushita M, Kitoh H, Mishima K, Nishida Y, Ishiguro N.

Pediatr Radiol. Vol. 44 ( 12 ) page： 1617 - 1619 2014.5

Biodistribution of locally or systemically transplantedosteoblast-like cells. Reviewed

Okabe YT, Kondo T, Mishima K, Hayase Y, Kato K, Mizuno M, Ishiguro N, Kitoh H.

Bone Joint Res. page： 76-81 2014.3

進行性骨化性線維異形成症におけるレントゲン学的診断指針 Invited Reviewed

三島　健一、鬼頭　浩史、芳賀　信彦、中島　康晴、金子　浩史、松下　雅樹、石黒　直樹

第25回日本整形外科学会骨系統疾患研究会記録集 2014

Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia Reviewed

Matsushita M, Kitoh H, Ohkawara B, Mishima K, Kaneko H, Ito M, Masuda A, Ishiguro N, Ohno K.

PLoS One. Vol. 8 ( 12 ) page： e81569 - 1619 2013.12

A comparative study of blade plate fixation and external fixation in osteotomies for slipped capital femoral epiphysis Reviewed

Kitoh H, Kitakoji T, Hattori T, Kaneko H, Mishima K, Matsushita M, Ishiguro N.

J Pediatr Orthop B. Vol. 22 ( 6 ) page： 542 - 547 2013.11

Perhexiline maleate in the treatment of fibrodysplasia ossificans progressiva: an open-labeled clinical trial Reviewed

Kitoh H, Achiwa M, Kaneko H, Mishima K, Matsushita M, Kadono I, Horowitz JD, Sallustio BC, Ohno K, Ishiguro N.

Orphanet J Rare Dis. Vol. 16 ( 8 ) page： 163 2013.10

A novel SOX9 H169Q mutation in a family with overlapping phenotype of mild campomelic dysplasia and small patella syndrome Reviewed

Matsushita M, Kitoh H, Kaneko H, Mishima K, Kadono I, Ishiguro N, Nishimura G.

Am J Med Genet A. Vol. 161A ( 10 ) page： 2528 - 2534 2013.10

Long-term outcome of gradual reduction using overhead traction for developmental dysplasia of the hip over 6 months of age Reviewed

Kaneko H, Kitoh H, Mishima K, Matsushita M, Ishiguro N.

J Pediatr Orthop. Vol. 33 ( 6 ) page： 628 - 634 2013.9

Prognostic factors for trochanteric overgrowth after containment treatment in Legg-Calvé-Perthes disease Reviewed

Kitoh H, Kaneko H, Mishima K, Matsushita M, Ishiguro N.

J Pediatr Orthop B. Vol. 22 ( 5 ) page： 432 - 436 2013.9

A novel in-frame deletion of the RUNX2 gene causes a classic form of cleidocranial dysplasia Reviewed

Matsushita M, Kitoh H, Kaneko H, Mishima K, Itoh Y, Tokita Y, Ishiguro N.

J Bone Miner Metab. Vol. 32 ( 1 ) page： 96 - 99 2013.4

Orthopaedic manifestations and diagnostic clues in children with Guillain-Barré syndrome Reviewed

Matsushita M, Kitoh H, Itomi K, Kitakoji T, Iwata K, Mishima K, Ishiguro N, Hattori T.

J Child Orthop. Vol. 7 ( 3 ) page： 177 - 182 2013.1

骨形成促進効果を有する既存薬の同定とその臨床応用の可能性 Invited Reviewed

三島　健一、鬼頭　浩史、金子　浩史、松下　雅樹、石黒　直樹

日本小児整形外科学会雑誌 2013

Isolated bifid rib: clinical and radiological findings in children. Reviewed

Kaneko H, Kitoh H, Mabuchi A, Mishima K, Matsushita M, Ishiguro N.

Pediatr Int. Vol. 54 ( 6 ) page： 820 - 823 2012.9

Early clinical and radiographic characteristics in fibrodysplasia ossificans progressiva: a report of two cases. Reviewed

Mishima K, Kitoh H, Katagiri T, Kaneko H, Ishiguro N.

J Bone Joint Surg Am. page： e52 2011.5

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Papers - MISHIMA Kenichi