研究者詳細 - 阪本　考司

論文 - 阪本　考司

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Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice. 査読有り国際誌

Wong CK, Smith CA, Sakamoto K, Kaminski N, Koff JL, Goldstein DR

Journal of immunology (Baltimore, Md. : 1950) 199 巻 ( 3 ) 頁： 1060 - 1068 2017年8月

Modified mesenchymal stem cells using miRNA transduction alter lung injury in a bleomycin model. 査読有り国際誌

Huleihel L, Sellares J, Cardenes N, Álvarez D, Faner R, Sakamoto K, Yu G, Kapetanaki MG, Kaminski N, Rojas M

American journal of physiology. Lung cellular and molecular physiology 313 巻 ( 1 ) 頁： L92 - L103 2017年7月

Progression of mean pulmonary arterial pressure in idiopathic pulmonary fibrosis with mild to moderate restriction 査読有り国際誌

Teramachi Ryo, Taniguchi Hiroyuki, Kondoh Yasuhiro, Ando Masahiko, Kimura Tomoki, Kataoka Kensuke, Suzuki Atsushi, Furukawa Taiki, Sakamoto Koji, Hasegawa Yoshinori

RESPIROLOGY 22 巻 ( 5 ) 頁： 986 - 990 2017年7月

COPD Assessment Test for measurement of health status in patients with idiopathic pulmonary fibrosis: A cross-sectional study. 査読有り

Matsuda T, Taniguchi H, Ando M, Kondoh Y, Kimura T, Kataoka K, Sakamoto K, Suzuki A, Furukawa T, Hasegawa Y

Respirology (Carlton, Vic.) 22 巻 ( 4 ) 頁： 721-727 2017年5月

Soluble thrombomodulin in bronchoalveolar lavage fluid is an independent predictor of severe drug-induced lung injury 査読有り国際誌

Suzuki Atsushi, Taniguchi Hiroyuki, Kondoh Yasuhiro, Ando Masahiko, Watanabe Naohiro, Kimura Tomoki, Kataoka Kensuke, Yokoyama Toshiki, Sakamoto Koji, Hasegawa Yoshinori

RESPIROLOGY 22 巻 ( 4 ) 頁： 744 - 749 2017年5月

Validation of the prognostic value of MMP-7 in idiopathic pulmonary fibrosis. 査読有り国際誌

Tzouvelekis A, Herazo-Maya JD, Slade M, Chu JH, Deiuliis G, Ryu C, Li Q, Sakamoto K, Ibarra G, Pan H, Gulati M, Antin-Ozerkis D, Herzog EL, Kaminski N

Respirology (Carlton, Vic.) 22 巻 ( 3 ) 頁： 486 - 493 2017年4月

Hemosiderin-laden macrophages are an independent factor correlated with pulmonary vascular resistance in idiopathic pulmonary fibrosis: a case control study 査読有り国際誌

Fukihara Jun, Taniguchi Hiroyuki, Ando Masahiko, Kondoh Yasuhiro, Kimura Tomoki, Kataoka Kensuke, Furukawa Taiki, Johkoh Takeshi, Fukuoka Junya, Sakamoto Koji, Hasegawa Yoshinori

BMC PULMONARY MEDICINE 17 巻 ( 1 ) 頁： 30 2017年2月

SH2 Domain-Containing Phosphatase-2 Is a Novel Antifibrotic Regulator in Pulmonary Fibrosis. 査読有り国際共著国際誌

Tzouvelekis A, Yu G, Lino Cardenas CL, Herazo-Maya JD, Wang R, Woolard T, Zhang Y, Sakamoto K, Lee H, Yi JS, DeIuliis G, Xylourgidis N, Ahangari F, Lee PJ, Aidinis V, Herzog EL, Homer R, Bennett AM, Kaminski N

American journal of respiratory and critical care medicine 195 巻 ( 4 ) 頁： 500 - 514 2017年2月

The St. George's Respiratory Questionnaire as a prognostic factor in IPF 査読有り国際誌

Furukawa Taiki, Taniguchi Hiroyuki, Ando Masahiko, Kondoh Yasuhiro, Kataoka Kensuke, Nishiyama Osamu, Johkoh Takeshi, Fukuoka Junya, Sakamoto Koji, Hasegawa Yoshinori

RESPIRATORY RESEARCH 18 巻 ( 1 ) 頁： 18 2017年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Respiratory Research

Background: It is unclear whether health related quality of life (HRQL) may have a predictive value for mortality in idiopathic pulmonary fibrosis (IPF). We investigated the relationship between HRQL assessed using the St. George's Respiratory Questionnaire (SGRQ) and survival time in patients with IPF, and tried to determine a clinical meaningful cut off value to predict poorer survival rates. Methods: We retrospectively analyzed consecutive patients with IPF who underwent an initial evaluation from May 2007 to December 2012. The diagnosis of IPF was made according to the 2011 international consensus guidelines. We used Cox proportional hazard models to identify independent predictors for mortality rate in patients with IPF. Results: We examined 182 eligible cases, average age was 66years old, and 86% were male. Mean levels of percent predicted FVC, DLco, six-minute-walk test distance, and the SGRQ total score were around 80%, 58%, 580m, and 34 points. On multivariate analysis, the SGRQ total score (hazard ratio [HR], 1.012; 95% confidence interval [CI] 1.001-1.023; P=<.029) and percent predicted FVC (HR, 0.957; 95% CI 0.944-0.971, P<.001) were independent predictors for mortality rate. Moreover, a score higher than 30 points in the SGRQ total score showed higher mortality rate (HR, 2.047; 95% CI, 1.329-3.153; P=<.001). Conclusions: The SGRQ total score was one of independent prognostic factors in patients with IPF. Total scores higher than 30 points were associated with higher mortality rates. Trial registration: This study was retrospective, observational study, so it is not applicable.

DOI： 10.1186/s12931-017-0503-3

Web of Science

Scopus

PubMed

Exercise hypoxaemia as a predictor of pulmonary hypertension in COPD patients without severe resting hypoxaemia. 査読有り

Nakahara Y, Taniguchi H, Kimura T, Kondoh Y, Arizono S, Nishimura K, Sakamoto K, Ito S, Ando M, Hasegawa Y

Respirology (Carlton, Vic.) 22 巻 ( 1 ) 頁： 120-125 2017年1月

Exogenous induction of unphosphorylated PTEN reduces TGFβ-induced extracellular matrix expressions in lung fibroblasts. 査読有り

25 巻 ( 1 ) 頁： 86-97 2017年1月

Depression Is Significantly Associated with the Health Status in Patients with Idiopathic Pulmonary Fibrosis. 査読有り

Matsuda T, Taniguchi H, Ando M, Kondoh Y, Kimura T, Kataoka K, Nishimura K, Nishiyama O, Sakamoto K, Hasegawa Y

Internal medicine (Tokyo, Japan) 56 巻 ( 13 ) 頁： 1637-1644 2017年

PULMONARY REHABILITATION IN PATIENTS WITH IDIOPATHIC PULMONARY FIBROSIS: COMPARISON WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE 査読有り

Arizono Shinichi, Taniguchi Hiroyuki, Sakamoto Koji, Kondoh Yasuhiro, Kimura Tomoki, Kataoka Kensuke, Ogawa Tomoya, Watanabe Fumiko, Tabira Kazuyuki, Kozu Ryo

SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES 34 巻 ( 4 ) 頁： 283 - 289 2017年

Impact of mild to moderate COPD on feasibility and prognosis in non-small cell lung cancer patients who received chemotherapy

Omote Norihito, Hashimoto Naozumi, Morise Masahiro, Sakamoto Koji, Miyazaki Shinichi, Ando Akira, Nakahara Yoshio, Hasegawa Yoshinori

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 12 巻頁： 3541 - 3547 2017年

Pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis: comparison with chronic obstructive pulmonary disease. 査読有り国際誌

Arizono S, Taniguchi H, Sakamoto K, Kondoh Y, Kimura T, Kataoka K, Ogawa T, Watanabe F, Tabira K, Kozu R

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 34 巻 ( 4 ) 頁： 283 - 289 2017年

Pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis: Comparison with chronic obstructive pulmonary disease

Arizono S., Taniguchi H., Sakamoto K., Kondoh Y., Kimura T., Kataoka K., Ogawa T., Watanabe F., Tabira K., Kozu R.

Sarcoidosis Vasculitis and Diffuse Lung Diseases 34 巻 ( 4 ) 頁： 283 - 289 2017年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Sarcoidosis Vasculitis and Diffuse Lung Diseases

Background: While the efficacy of pulmonary rehabilitation (PR) in chronic obstructive pulmonary disease (COPD) has been well established, emerging evidence also suggests its benefit in idiopathic pulmonary fibrosis (IPF). However, the differences and similarities between how PR affects diseases with different physiologies remain unknown. Objective: This study aimed to compare the efficacy of PR in COPD and IPF patients by performing multifactorial evaluation with various exercise capacity measurements, and dyspnea and health-related quality of life (QoL) assessment. Methods: Twenty-two IPF patients (%vital capacity: 72%) and 27 COPD patients (%forced expiratory volume1: 43%) were recruited. Subjects who completed a 10-week outpatient PR program were analyzed. We assessed five exercise capacity indicators (6-minute walking distance, incremental shuttle walking distance, endurance time, peak work rate, and peak values for oxygen uptake [peak VO2]), dyspnea (Baseline Dyspnea Index: BDI), and health-related QoL (St. George's Respiratory Questionnaire: SGRQ) at baseline and immediately following completion of the PR program. Results: After 10 weeks of PR, all exercise capacity measurements, except VO2, as well as BDI and SGRQ score improved significantly (p<0.05) in both disease groups. The magnitude of the observed changes in each outcome, assessed by the effect size, was comparable between IPF and COPD patients. This was also true for endurance time, the measurement most responsive to PR, with a large effect size. Conclusions: PR can result in comparable improvements in exercise capacity, including endurance time, and dyspnea and HRQoL in both IPF and COPD patients after 10 weeks of exercise training.

Scopus

Impact of Thin-Section Computed Tomography-Determined Combined Pulmonary Fibrosis and Emphysema on Outcomes Among Patients With Resected Lung Cancer. 査読有り

Hashimoto N, Iwano S, Kawaguchi K, Fukui T, Fukumoto K, Nakamura S, Mori S, Sakamoto K, Wakai K, Yokoi K, Hasegawa Y

The Annals of thoracic surgery 102 巻 ( 2 ) 頁： 440-7 2016年8月

Mean pulmonary arterial pressure as a prognostic indicator in connective tissue disease associated with interstitial lung disease: a retrospective cohort study. 査読有り

Takahashi K, Taniguchi H, Ando M, Sakamoto K, Kondoh Y, Watanabe N, Kimura T, Kataoka K, Suzuki A, Ito S, Hasegawa Y

BMC pulmonary medicine 16 巻 ( 1 ) 頁： 55 2016年4月

Biomarkers in the Evaluation and Management of Idiopathic Pulmonary Fibrosis. 査読有り

Tzouvelekis A, Herazo-Maya J, Sakamoto K, Bouros D

Current topics in medicinal chemistry 16 巻 ( 14 ) 頁： 1587-98 2016年

Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers. 査読有り

Kohnoh T, Hashimoto N, Ando A, Sakamoto K, Miyazaki S, Aoyama D, Kusunose M, Kimura M, Omote N, Imaizumi K, Kawabe T, Hasegawa Y

Cancer cell international 16 巻頁： 33 2016年

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