Faculty Profiles - OHTSUKI Chikara

Papers - OHTSUKI Chikara

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In Situ and Ex Situ Studies of Ring-Like Assembly of Silica Nanoparticles in the Presence of Poly(propylene oxide)–Poly(ethylene oxide) Block Copolymers Reviewed

Rintaro Takahashi, Kazuki Yamamoto, Ryo Sugahara, Ryusuke Otake, Keisuke Hayashi, Jin Nakamura, Chikara Ohtsuki, Sadahito Aoshima, Ayae Sugawara-Narutaki

Langmuir 2023.8

Transformation behaviour of salts composed of calcium ions and phosphate esters with different linear alkyl chain structures in a simulated body fluid modified with alkaline phosphatase

Taishi Yokoi, Akiyoshi Mio, Jin Nakamura, Ayae Sugawara-Narutaki, Masakazu Kawashita, Chikara Ohtsuki

Science and Technology of Advanced Materials Vol. 23 ( 1 ) page： 341 - 351 2022.12

Biological properties of self-assembled nanofibers of elastin-like block polypeptides for tissue-engineered vascular grafts: platelet inhibition, endothelial cell activation and smooth muscle cell maintenance Reviewed International journal

Natsume K, Nakamura J, Sato K, Ohtsuki C, Sugawara-Narutaki A

Regen Biomater Vol. 10 ( rbac111 ) page： rbac111 2022.12

Organic modification of layered zirconium phosphate/phosphonate for controlled release of therapeutic inorganic ions

Jin Nakamura, Ryoya Ito, Ryohei Kozaki, Ayae Sugawara-Narutaki, Chikara Ohtsuki

Science and Technology of Advanced Materials Vol. 22 ( 1 ) page： 1000 - 1012 2021.12

Selective adsorption of dyes on TiO₂-modified hydroxyapatite photocatalysts morphologically controlled by solvothermal synthesis

Tomoyo Goto, Sung Hun Cho, Chikara Ohtsuki and TohruSekino

Journal of Environmental Chemical Engineering Vol. 9 ( 4 ) page： 105738 2021.8

Thixotropic Hydrogels Composed of Self-Assembled Nanofibers of Double-Hydrophobic Elastin-Like Block Polypeptides

Yusuke Sugioka, Jin Nakamura, Chikara Ohtsuki and Ayae Sugawara-Narutaki

International Journal of Molecular Science Vol. 22 ( 8 ) page： 4104 2021.4

Incorporation of tetracarboxylate ions into octacalcium phosphate for the development of next-generation biofriendly materials

Taishi Yokoi, Tomoyo Goto, Mitsuo Hara, Tohru Sekino, Takahiro Seki, Masanobu Kamitakahara, Chikara Ohtsuki, Satoshi Kitaoka, Seiji Takahashi, Masakazu Kawashita

Communications Chemistry Vol. 4 ( 1 ) page： 4 2021.1

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

<title>Abstract</title>Octacalcium phosphate (OCP; Ca8(HPO4)2(PO4)4 ∙ 5H2O) is a precursor of hydroxyapatite found in human bones and teeth, and is among the inorganic substances critical for hard tissue formation and regeneration in the human body. OCP has a layered structure and can incorporate carboxylate ions into its interlayers. However, studies involving the incorporation of tetracarboxylic and multivalent (pentavalent and above) carboxylic acids into OCP have not yet been reported. In this study, we investigate the incorporation of pyromellitic acid (1,2,4,5-benzenetetracarboxylic acid), a type of tetracarboxylic acid, into OCP. We established that pyromellitate ions could be incorporated into OCP by a wet chemical method using an acetate buffer solution containing pyromellitic acid. The derived OCP showed a brilliant blue emission under UV light owing to the incorporated pyromellitate ions. Incorporation of a carboxylic acid into OCP imparted new functions, which could enable the development of novel functional materials for biomedical applications.

DOI： 10.1038/s42004-020-00443-5

Web of Science

PubMed

Other Link： http://www.nature.com/articles/s42004-020-00443-5

Preparation of layered calcium silicate organically modified with two types of functional groups for varying chemical stability

Jin Nakamura, Yuna Suzuki, Ryosuke Narukawa, Ayae Sugawara-Narutaki, Chikara Ohtsuki

Journal of Asian Ceramic Societies Vol. 9 ( 1 ) page： 90 - 100 2021.1

Behaviour of calcium phosphate ester salts in a simulated body fluid modified with alkaline phosphatase: a new concept of ceramic biomaterials Reviewed

Taishi Yokoi, Tatsuki Ujiyama, Jin Nakamura, Masakazu Kawashita, Chikara Ohtsuki

Materials Advances Vol. 1 ( 9 ) page： 3215 - 3220 2020.12

Human stem cell response to layered zirconium phosphate Reviewed

Jin Nakamura, Kanta Endo, Ayae Sugawara-Narutaki, Chikara Ohtsuki(DOI: 10.1039/d0ra04924g)

RSC Advances Vol. 10 page： 36051-36057 2020.9

Tearable and Fillable Composite Sponges Capable of Heat Generation and Drug Release in Response to Alternating Magnetic Field Reviewed

Koichiro Hayashi, Atsuto Tokuda, Jin Nakamura, Ayae Sugawara-Narutaki, Chikara Ohtsuki

Materials Vol. 13 ( 16 ) page： 3637 2020.8

Hydroxyapatite Formation from Octacalcium Phosphate and Its Related Compounds: A Discussion of the Transformation Mechanism Reviewed

Taishi Yokoi, Tomoyo Goto, Takeharu Kato, Seiji Takahashi, Jin Nakamura, Tohru Sekino, Chikara Ohtsuki, Masakazu Kawashita

Bulletin of the Chemical Society of Japan Vol. 93 ( 5 ) page： 701 - 707 2020.5

Rheology of Dispersions of High-Aspect-Ratio Nanofibers Assembled from Elastin-Like Double-Hydrophobic Polypeptides Reviewed

Ayae Sugawara-Narutaki, Sawako Yasunaga, Yusuke Sugioka, Duc H. T. Le, Issei Kitamura, Jin Nakamura, Chikara Ohtsuki

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol. 20 ( 24 ) 2019.12

Ring-Like Assembly of Silica Nanospheres in the Presence of Amphiphilic Block Copolymer: Effects of Particle Size Reviewed

Chisato Atsumi, Shintaro Araoka, Kira B. Landenberger, Arihiro Kanazawa, Jin Nakamura, Chikara Ohtsuki, Sadahito Aoshima, Ayae Sugawara-Narutaki

LANGMUIR Vol. 34 ( 26 ) page： 7751 - 7758 2018.7

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER CHEMICAL SOC

Block copolymer-mediated self-assembly of colloidal nanoparticles has attracted great attention for the fabrication of a wide variety of nanoparticle arrays. We have previously shown that silica nanospheres (SNSs) 15 nm in diameter assemble into ring-like nanostructures in the presence of amphiphilic block copolymers poly[(2-ethoxyethyl vinyl ether)-block-(2-methoxyethyl vinyl ether)] (EOVE-MOVE) in an aqueous phase. Here, the effects of particle size of SNSs on this polymer-mediated self-assembly are studied systematically using scanning electron microscopy to observe SNSs of seven different sizes between 13 to 42 nm. SNSs of 13, 16, 19, and 21 nm in diameter assemble into nanorings in the presence of EOVE-MOVE. In contrast, larger SNSs of 26, 34, and 42 nm aggregate heavily, form chain-like networks, and remain dispersed, respectively, instead of forming ring-like nanostructures. The assembly trend for 26-42 nm-SNSs agrees with that expected from the increased colloidal stability for larger particles. Time-course observation for the assembled morphology of 16 nm-SNSs reveals that the nanorings, once formed, assemble further into network-like structures, as if the nanorings behave as building units for higher-order assembly. This indicates that the ring-like assembly is a fast process that can proceed onto random colloidal aggregation. Detailed analysis of nanoring structures revealed that the average number of SNSs comprising one ring decreased from 5.0 to 3.1 with increasing the SNS size from 13 to 21 nm. A change in the number of ring members was also observed when the length of EOVE-MOVE varied while the size of SNSs was fixed. Dynamic light scattering measurements and atomic force microscopy confirmed the SNSs/polymer composite structures. We hypothesize that a stable composite morphology may exist that is influenced by both the size of SNSs and the polymer molecular structures.

DOI： 10.1021/acs.langmuir.8b00420

Web of Science

PubMed

Apatite coating on dendrimer-modified buckypaper and the formation of nanoapatite on MWCNTs Reviewed

Tomoyuki Tajima, Tomoaki Tanaka, Hideaki Miyake, Ill Yong Kim, Chikara Ohtsuki and Yutaka Takaguchi

Polymer Journal 2018.5

Periodic Surface-Ring Pattern Formation for Hydroxyapatite Thin Films Formed by Biomineralization-Inspired Processes

Yulai Han, Tatsuya Nishimura, Misato Iimura, Takeshi Sakamoto, Chikara Ohtsuki, Takashi Kato

LANGMUIR Vol. 33 ( 38 ) page： 10077 - 10083 2017.9

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER CHEMICAL SOC

Surface morphology is a key factor that might significantly influence the properties of biomaterials. In this study, periodic surface-ring structures have been constructed for calcium phosphate thin films via biomineralization-inspired crystallization process. The patterned octacalcium phosphate crystals have been obtained on poly(2-hydroxyethyl methacrylate) (PHEMA) matrix in the presence of poly(acrylic acid) (PAA). The patterned surface morphologies of the crystal thin films could be tuned by the amount of PAA additives. In addition, the rapid and topotactic transformation to hydroxyapatite (HAP) thin films with surface-ring structures has also been achieved. This study may provide new strategy toward the design of functional calcium phosphate-based thin-film hybrids.

DOI： 10.1021/acs.langmuir.7b02126

Web of Science

Double-hydrophobic elastin-like polypeptides with added functional motifs: Self-assembly and cytocompatibility

Duc H. T. Le, Yoko Tsutsui, Ayae Sugawara-Narutaki, Hiroshi Yukawa, Yoshinobu Baba, Chikara Ohtsuki

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A Vol. 105 ( 9 ) page： 2475 - 2484 2017.9

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

We have recently developed a novel double-hydrophobic elastin-like triblock polypeptide called GPG, designed after the uneven distribution of two different hydrophobic domains found in elastin, an extracellular matrix protein providing elasticity and resilience to tissues. Upon temperature trigger, GPG undergoes a sequential self-assembling process to form flexible beaded nanofibers with high homogeneity and excellent dispersibility in water. Given that GPG might be a potential elastin-mimetic material, we sought to explore the biological activities of this block polypeptide. Besides GPG, several functionalized derivatives were also constructed by fusing functional motifs such as KAAK or KAAKGRGDS at the C-terminal of GPG. Although the added motifs affected the kinetics of fiber formation and -sheet contents, all three GPGs assembled into beaded nanofibers at the physiological temperature. The resulting GPG nanofibers preserved their beaded structures in cell culture medium; therefore, they were coated on polystyrene substrates to study their cytocompatibility toward mouse embryonic fibroblasts, NIH-3T3. Among the three polypeptides, GPG having the cell-binding motif GRGDS derived from fibronectin showed excellent cell adhesion and cell proliferation properties compared to other conventional materials, suggesting its promising applications as extracellular matrices for mammalian cells. (C) 2017 Wiley Periodicals, Inc.

DOI： 10.1002/jbm.a.36105

Web of Science

PubMed

Bioactive Glass-Ceramics

Yokoi, T; Miyazaki, T; Kawashita, M; Ohtsuki, C

NANOBIOCERAMICS FOR HEALTHCARE APPLICATIONS page： 213 - 237 2017

Rapid and topotactic transformation from octacalcium phosphate to hydroxyapatite (HAP): a new approach to self-organization of free-standing thin-film HAP-based nanohybrids Reviewed

Satoshi Kajiyama, Takeshi Sakamoto, Moe Inoue, Tatsuya Nishimura, Taishi Yokoi, Chikara Ohtsuki and Takashi Kato

CrystEngComm Vol. 18 page： 8388-8395 2016.9

Fabrication of Porous α-TCP/Gellan Gum Scaffold for Bone Tissue Engineering Reviewed

Jian Wen, Ill Yong Kim, Koichi Kikuta and Chikara Ohtsuki

Journal of Nanoscience and Nanotechnology Vol. 16 page： 3077-3083 2016.3

Optimization of Sintering Conditions for Improvement of Mechanical Property of α-Tricalcium Phosphate Blocks

Jian Wen, Ill Yong Kim, Koichi Kikuta and Chikara Ohtsuki

Global Journal of Biotechnology and Biomaterial Science Vol. 2 page： 1-7 2016.1

Hydroxyapatite Formation from Calcium Carbonate Single Crystal under Hydrothermal Condition: Effects of Processing Temperature

Ill Yong Kim, and Chikara Ohtsuki

Ceramics International Vol. 42 page： 1886-1890 2015.11

Continuous expansion of the interplanar spacing of octacalcium phosphate by incorporation of dicarboxylate ions with a side chain Reviewed

Taishi Yokoi, Masanobu Kamitakahara and Chikara Ohtsuki

Dalton Transactions Vol. 44 page： 7943-7950 2015.5

Hydroxyapatite formation on titania-based materials in a solution mimicking body fluid: Effects of manganese and iron addition in anatase Reviewed

Euisup Shin, Ill Yong Kim, Sung Baek Cho and Chikara Ohtsuki

Materials Science and Engineering: C Vol. 48 page： 279-286 2015.3

Calcium phosphate-forming ability of magnetite and related materials in a solution mimicking in vivo conditions Reviewed

Yasuyuki Kato, Taishi Yokoi, Euisup Shin, Ill Yong Kim, Masakazu Kawashita, Koichi Kikuta and Chikara Ohtsuki

Journal of Asian Ceramic Societies Vol. 3 page： 44-49 2015.3

Hydroxyapatite formation on oxidized cellulose nanofibers in a solution mimicking body fluid Reviewed

Seira Morimune-Moriya, Sakina Kondo, Ayae Sugawara-Narutaki, Tatsuya Nishimura, Takashi Kato and Chikara Ohtsuki

Polymer Journal 2015.2

A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants Reviewed

Anthony L. B. Maçon, Taek B. Kim, Esther M. Valliant, Kathryn Goetschius, Richard K. Brow, Delbert E. Day, Alexander Hoppe, Aldo R. Boccaccini, Ill Yong Kim, Chikara Ohtsuki, Tadashi Kokubo, Akiyoshi Osaka, Maria Vallet-Regí, Daniel Arcos, Leandro Fraile, Antonio J. Salinas, Alexandra V. Teixeira, Yuliya Vueva, Rui M. Almeida, Marta Miola, Chiara Vitale-Brovarone, Enrica Verné, Wolfram Höland, and Julian R. Jones

Journal of Materials Science: Materials in Medicine Vol. 26 page： Article 115 (10 pages) 2015.2

Fabrication of Self-Standing Films Consisting of Enamel-Like Oriented Nanorods Using Artificial Peptide Reviewed

Kazuki Aita, Yuya Oaki, Chikara Ohtsuki and Hiroaki Imai

CrystEngComm Vol. 17 page： 5551-5555 2015

Hydroxyapatite formation through dissolution-precipitation reaction: Effects of solubility of starting materials Reviewed

Ill Yong Kim, Koichi Kikuta and Chikara Ohtsuki

Ceramics International 2014.6

Utilization of star-shaped polymer architecturein the creation of high-density polymer brush coatings for the prevention of platelet and bacteria adhesion Reviewed

Masayasu Totani, Tsuyoshi Ando, Kayo Terada, Takaya Terashima, Ill Yong Kim, Chikara Ohtsuki, Chuanwu Xi, Kenichi Kuroda and Masao Tanihara

Biomaterials Science, 2014 2014.5

Characteristics of glass ionomer cements composed of glass powders in CaO-SrO-ZnO-SiO₂ system prepared by two dfferent synthetic routes Reviewed

Ill Yong Kim, Chikara Ohtsuki, Aisling Coughlan, Lana Placek, Anthony W. Wren, Mark R. Towler

Journal of Materials Science: Materials in Medicine Vol. 24 ( 12 ) page： 2677-2682 2013.12

Effects of polymer concentration on the morphology of calcum phosphate crystals formed in polyacrylamide hydrogels Reviewed

Taishi Yokoi, Masakazu Kawashita and Chikara Ohtsuki

Journal of Crystal Growth Vol. 383 page： 166-171 2013.11

Behavior of hydroxyapatite crystals in a simulated body fluid: Effects of crystal face Reviewed

Hiroyuki Shibata, Taishi Yokoi, Tomoyo Goto, Ill Yong Kim, Masakazu Kawashita, Koichi Kikuta and Chikara Ohtsuki

Journal of the Ceramic Society of Japan Vol. 121 page： 807-812 2013.9

Biomimetic mineralization of calcium phosphates in polymeric hydrogels containing carboxyl groups Reviewed

Taishi Yokoi, Masakazu Kawashita and Chikara Ohtsuki

Journal of Asian Ceramic Societies Vol. 1 page： 155-162 2013.8

Biomineralization on chemically synthesized collagen containing immobilized poly-γ-glutamic acid

Toshiki Miyazaki, Akimasa Kuramoto, Atsuhide Hirakawa, Yuki Shirosaki and Chikara Ohtsuki

Dental Materials Journal Vol. 32 ( 4 ) page： 544-549 2013.7

Formation of serrated nanorods of hydroxyapatite through organic modification under hydrothermal processing Reviewed

S. Prakash Parthiban, Ill Yong Kim, Koichi Kikuta and Chikara Ohtsuki

Journal of Nanoparticle Research Vol. 15 page： 1657-1666 2013.5

Formation of organically modified octacalcium phosphate in solutions containing various amounts of benzenedicarboxylic acids Reviewed

Taishi Yokoi, Masanobu Kamitakahara, Masakazu Kawashita and Chikara Ohtsuki

Journal of the Ceramic Society of Japan Vol. 121 ( 2 ) page： 219-225 2013.2

Development of highly functionalized ceramic biomaterials Invited Reviewed

Chikara Ohtsuki

Journal of the Ceramic Society of Japan Vol. 121 ( 2 ) page： 129-134 2013.2

Apatite mineralization behavior on polyglutamic acid hydrogels in aqueous condition: Effects of molecular weight Reviewed

Toshiki Miyazaki, Juntarou Mukai, Eiichi Ishida and Chikara Ohtsuki

Bio-Medical Materials and Engineering Vol. 23 ( 1 ) page： 339-347 2013.1

Inhibitory effects of doped aluminum and silicon on HAp-forming ability of titania in simulated body fluid

Euisup Shin, Ill Yong Kim, Sung Baek Cho and Chikara Ohtsuki

Key Engineering Materials Vol. 529-530 page： 641-645 2013

Effects of Heat Treatment on Apatite Formation of CaO-SiO₂-PEEK Composites

Sung Baek Cho, Eung Mo An, Sujeong Lee, Hee Dong Jang, Ill Yong Kim, Chikara Ohtsuki and Yun Jong Kim

Key Engineering Materials Vol. 529-530 page： 436-440 2013

Formation of Oriented Hydroxyapatite Crystals in a Hydrogel

Taishi Yokoi, Ill Yong Kim, Masakazu Kawashita and Chikara Ohtsuki

Key Engineering Materials Vol. 529-530 page： 24-28 2013

Interfacial Shear Strength of Bioactive-Coated Carbon Fiber Reinforced Polyetheretherketone after In Vivo Implantation Reviewed

Ichiro Nakahara, Masaki Takao, Tomoyo Goto, Chikara Ohtsuki, Shigeru Hibino, Nobuhiko Sugano

Journal of Orthopaedic Research Vol. 30 page： 1618-1652 2012.10

Formation of Oriented Hydroxyapatite Rods by Hydrothermal Treatment of Calcite Single Crystal Reviewed

Ill Yong Kim, Koichi Kikuta and Chikara Ohtsuki

Korean Journal of Materials Research Vol. 22 ( 8 ) page： 397-402 2012.9

Mineralization of Calcium Phosphate on Octacalcium Phosphate in a Solution Mimicking In Vivo Conditions Reviewed

Taishi Yokoi, Ill Yong Kim, Chikara Ohtsuki

Phosphorus Research Bulletin Vol. 26 page： 71-76 2012.9

Synthesis of octacalcium phosphate with incorporated succinate and suberate ions Reviewed

Taishi Yokoi, Hidetaka Kato, Ill Yong Kim, Koichi Kikuta, Masakazu Kawashita and Chikara Ohtsuki

Ceramics International Vol. 38 ( 5 ) page： 3815-3820 2012.7

Hydrothermal Synthesis of Composites of Well-crystallized Hydroxyapatite and Poly(vinyl alcohol) Hydrogel Reviewed

Tomoyo Goto, Ill Yong Kim, Koichi Kikuta and Chikara Ohtsuki

Materials Science and Engineering: C Vol. 32 ( 3 ) page： 397-403 2012.4

Formation of octacalcium phosphates with co-incorporated succinate and suberate ions Reviewed

Taishi Yokoi, Hidetaka Kato, Ill Yong Kim, Koichi Kikuta, Masanobu Kamitakahara, Masakazu Kawashita and Chikara Ohtsuki

Dalton Transactions Vol. 41 ( 9 ) page： 2732-2737 2012.4

Comparative study of hydroxyapatite formation from α- and β-tricalcium phosphates under hydrothermal conditions Reviewed

Tomoyo Goto, Ill Yong Kim, Koichi Kikuta and Chikara Ohtsuki

Journal of the Ceramic Society of Japan Vol. 120 ( 4 ) page： 131-137 2012.4

融合マテリアル：分子制御による材料創成と機能開拓

加藤隆史, 大槻主税

未来材料 Vol. 12 ( 3 ) page： 49-53 2012.3

Hydroxyapatite formation by solvothermal treatment of α-tricalcium phosphate with water-ethanol solution Reviewed

Tomoyo Goto, Ill Yong Kim, Koichi Kikuta and Chikara Ohtsuki

Ceramics International Vol. 38 ( 2 ) page： 1003-1010 2012.3

Strategy to reduce carbonate incorporation in the fabrication of hydroxyapatite nanopowders Reviewed

Selvakumar Prakash Parthiban, Ill Yong Kim, Koichi Kikuta and Chikara Ohtsuki

Journal of the Ceramic Society of Japan Vol. 119 ( 1396 ) page： 947-953 2011.12

Effect of Protein Adsorption onto the Dissolution of Silicon-Substituted Hydroxyapatite Reviewed

Claudia Manuela Botelho, Roger Brooks, Masanobu Kanitakahara, Chikara Ohtsuki, Serena Best, Maria Ascensão Lopers, Neil Rushton, William Bonfield and José Domingos Santos

Journal of Encapsulation and Adsorption Science Vol. 1 ( 4 ) page： 72-79 2011.12

Effect of urea on formation of hydroxyapatite through double-step hydrothermal processing Reviewed

Selvakumar Prakash Parthiban, Ill Yong Kim, Koichi Kikuta and Chikara Ohtsuki

Materials Science and Engineering: C Vol. 31 ( 7 ) page： 1383-1388 2011.10

Thermoreversible behavior of κ-carrageenan and its apatite-forming ability in simulated body fluid Reviewed

Ill Yong Kim , Ryota Iwatsuki, Koichi Kikuta, Yumi Morita, Toshiki Miyazaki and Chikara Ohtsuki

Materials Science and Engineering: C Vol. 31 ( 7 ) page： 1472-1476 2011.10

Effects of ethanol addition on formation of hydroxyapatite through hydrothermal treatment of dicalcium phosphate dehydrate Reviewed

T. Goto, M. Kamitakahara, I. Y. Kim and C. Ohtsuki

IOP Conference Series: Materials Science and Engineering Vol. 18 page： 192014 2011.7

Effetcs of Monocarboxylic Acid Addition on Crystallization of Calcium Phosphate in a Hydrogel Matrix Reviewed

Taishi Yokoi, Masakazu Kawashita and Chikara Ohtsuki

IOP Conference Series: Materials Science and Engineering Vol. 18 page： 192012 2011.7

In vitro apatite-forming ability of hydrogels derived from sodium carboxymethylcellulose Reviewed

M.-Y. Koh, Y. Morita, T. Miyazaki and C. Ohtsuki

IOP Conference Series: Materials Science and Engineering Vol. 18 page： 192004 2011.7

In vitro study of carbonated hydroxyapatite compacts prepared by double-step hydrothermal method Reviewed

S. Prakash Parthiban, Ill Yong Kim, Koichi Kikuta and Chikara Ohtsuki

IOP Conference Series: Materials Science and Engineering Vol. 18 page： 192008 2011.7

Modification of polyglutamic acid with silanol groups and calcium salts to induce calcification in a simulated body fluid Reviewed

Mi-Young Koh, Toshiki Miyazaki and Chikara Ohtsuki

Journal of Biomaterials Applications Vol. 25 ( 6 ) page： 581-594 2011.2

Effect of ammonium carbonate on formation of calcium-deficient hydroxyapatite through double-step hydrothermal processing Reviewed

S. Prakash Parthiban, Ill Yong Kim, Koichi Kikuta and Chikara Ohtsuki

Journal of Materials Science: Materials in Medicine Vol. 22 ( 2 ) page： 209-216 2011.2

GRAPE^® Technology：チタン合金に骨組織親和性を付与する微小空間デザインと熱酸化

尾坂明義, 杉野篤史, 都留寛治, 城﨑由紀, 大槻主税, 藏本孝一

人工臓器 Vol. 40 ( 1 ) page： 66-69 2011

Sensing of Protein Adsorption by Composites Consisting of Silver Nanoparticles and Hydroxyapatite Reviewed

Chikara Ohtsuki, Yuji Ichikawa, Hiroyuki Shibata, Tsukasa Torimoto and Ill Yong Kim

Advances in Science and Technology Vol. 76 page： 90-99 2010.9

Crystallization of calcium phosphate in polyacrylamide hydrogels containing phosphate ions Reviewed

Taishi Yokoi, Masakazu Kawashita, Koichi Kikuta and Chikara Ohtsuki

Journal of Crystal Growth Vol. 312 page： 2376-2383 2010.8

Fabrication of porous blocks of calcium phosphate through hydrothermal processing under glycine coexistence Reviewed

Giichiro KAWACHI, Hidetoshi MISUMI, Hirotaka FUJIMORI, Seishi GOTO, Chikara OHTSUKI, Masanobu KAMITAKAHARA and Koji IOKU

Journal of the Ceramic Society of Japan Vol. 118 ( 7 ) page： 559-563 2010.7

Hydroxyapatite formation on porous ceramics of alpha-tricalcium phosphate in a simulated body fluid Reviewed

Tomohiro Uchino, Kohei Yamaguchi, Ichiro Suzuki, Masanobu Kamitakahara, Makoto Otsuka and Chikara Ohtsuki

Journal of Materials Science, Materials in Medicine Vol. 21 ( 6 ) page： 1921-1926 2010.6

Formation of octacalcium phosphate with incorporated succinic acid through gel-mediated processing Reviewed

Taishi YOKOI, Hidetaka KATO, Masanobu KAMITAKAHARA, Masakazu KAWASHITA and Chikara OHTSUKI

Journal of the Ceramic Society of Japan Vol. 118 ( 6 ) page： 491-497 2010.6

Apatite formation abilities of various carrageenan gels in simulated body environment Reviewed

Ryo NAKATA, Toshiki MIYAZAKI, Yumi MORITA, Eiichi ISHIDA, Ryota IWATSUKI and Chikara OHTSUKI

Journal of the Ceramic Society of Japan Vol. 118 ( 6 ) page： 487-490 2010.6

Control of setting behavior of calcium phosphate paste using gelatinized starch Reviewed

Takahiro KAWAI, Noriko FUJISAWA, Ichiro SUZUKI, Chikara OHTSUKI, Yuta MATSUSHIMA and Hidero UNUMA

Journal of the Ceramic Society of Japan Vol. 118 ( 6 ) page： 421-424 2010.6

Acceleration of calcium phosphate formation on bioactive PMMA-based bone cement by controlling spatial design Reviewed

Yuki Totani, Atsushi Sugino, Toshiki Miyazaki and Chikara Ohtsuki

Materials Science and Engineering: C Vol. 30 ( 4 ) page： 624-630 2010.5

Synthesis of a bi-structured hybrid in a CaO-SiO₂-PTMO system and in vitro evaluation on its potential of bone-bonding property Reviewed

Mi-Young Koh, Hyun-Min Kim and Chikara Ohtsuki

Materials Science and Engineering: C Vol. 30 ( 3 ) page： 454-459 2010.4

Sensing of Protein Adsorption with a Porous Bulk Composite Comprising Silver Nanoparticles Deposited on Hydroxyapatite Reviewed

Chikara Ohtsuki, Yuji Ichikawa, Hiroyuki Shibata, Giichiro Kawachi, Tsukasa Torimoto and Shin-ichi Ogata

Journal of Materials Science: Materials in Medicine Vol. 21 ( 4 ) page： 1225-1232 2010.4

In vitro apatite formation on organic-inorganic hybrids in the CaO-SiO₂-PO_5/2-poly(tetramethylene oxide) system Reviewed

Mi-Young Koh, Masanobu Kamitakahara, Ill-Yong Kim, Koichi Kikuta and Chikara Ohtsuki

Journal of Materials Science: Materials in Medicine Vol. 21 ( 2 ) page： 385-392 2010.2

Effects of surface carboxylic acid groups of cerasomes, morphologically stable vesicles having a silica surface, on biomimetic deposition of hydroxyapatite in body fluid conditions Reviewed

Mineo Hashizume, Hiroyuki Horii, Jun-ichi Kikuchi, Masanobu Kamitakahara, Chikara Ohtsuki and Masao Tanihara

Journal of Materials Science: Materials in Medicine Vol. 21 ( 1 ) page： 11-19 2010.1

Biomimetic mineralization of calcium phosphate crystals in polyacrylamide hydrogel: Effect of concentrations of calcium and phosphate ions on crystalline phases and morphology Reviewed

Taishi Yokoi, Masakazu Kawashita, Koichi Kikuta and Chikara Ohtsuki

Materials Science and Engineering: C Vol. 30 page： 154-159 2010.1

Hydroxyapatite-forming capability and mechanical properties of organic-inorganic hybrids and alpha-tricalcium phosphate porous bodies Reviewed

Tomohiro UCHINO, Masanobu KAMITAKAHARA, Makoto OTSUKA and Chikara OHTSUKI

Journal of the Ceramic Society of Japan Vol. 118 ( 1 ) page： 57-61 2010.1

Effect of preparation conditions on the properties of bioactive glasses for testing SBF Reviewed

Masanobu Kamitakahara, Tasuku Yagi and Chikara Ohtsuki

Journal of Materials Science: Materials in Medicine Vol. 20 ( 12 ) page： 2419-2426 2009.12

Characterisation and mechanical testing of hydrothermally treated HA/ZrO₂ composites Reviewed

D. J. Curran, T. J. Fleming, G.Kawachi, C. Ohtsuki and M. R. Towler

Journal of Materials Science: Materials in Medicine Vol. 20 ( 11 ) page： 2235-2241 2009.11

Fabrication of Spherical CaO-SrO-ZnO-SiO₂ Particles by Sol-gel Processing Reviewed

Ill Yong Kim, Mark R. Towler, Anthony Wren and Chikara Ohtsuki

Journal of Materials Science: Materials in Medicine Vol. 20 ( 11 ) page： 2267-2273 2009.11

The effect of glass synthesis route on mechanical and physical properties of resultant glass ionomer cements Reviewed

A. Wren, O.M. Clarkin, F.R. Laffir, C. Ohtsuki, I.Y. Kim and M.R. Towler

Journal of Materials Science: Materials in Medicine Vol. 20 ( 10 ) page： 1991-1999 2009.10

Apatite Mineralization Abilities and Mechanical Properties of Covalently Cross-linked Pectin Hydrogels Reviewed

Takashi Ichibouji, Toshiki Miyazaki, Eiichi Ishida, Atsushi Sugino and Chikara Ohtsuki

Materials Science and Engineering: C Vol. 29 ( 6 ) page： 1765-1769 2009.8

Bioactive Composites Consisting of PEEK and Calcium Silicate Powders Reviewed

Ill Yong Kim, Atsushi Sugino, Koichi Kikuta, Chikara Ohtsuki and Sung Baek Cho

Journal of Biomaterials Applications Vol. 24 page： 105-118 2009.8

Protein adsorption on needle-shaped hydroxyapatite prepared by hydrothermal treatment of mixture composed of CaHPO₄^.2H₂O and beta-Ca₃(PO₄)₂ Reviewed

Giichiro KAWACHI, Tomoko WATANABE, Shin-ichi OGATA, Masanobu KAMITAKAHARA and Chikara OHTSUKI

Journal of the Ceramic Society of Japan Vol. 117 ( 7 ) page： 847-850 2009.7

Formation of needle-like hydroxyapatite by hydrothermal treatment of CaHPO₄^.2H₂O combined with β-Ca₃(PO₄)₂ Reviewed

Tomoko WATANABE, Giichiro KAWACHI, Masanobu KAMITAKAHARA, Koichi KIKUTA and *Chikara OHTSUKI

Journal of the Ceramic Society of Japan Vol. 117 ( 6 ) page： 759-764 2009.6

Synthesis of calcium phosphate crystals in a silica hydrogel containing phosphate ions Reviewed

Taishi Yokoi, Masakazu Kawashita, Giichiro Kawachi, Koichi Kikuta and Chikara Ohtsuki

Journal of Materials Research Vol. 24 ( 6 ) page： 2154-2160 2009.6

Bioactive ceramic-based materials with designed reactivity for bone tissue regeneration Reviewed

Chikara Ohtsuki, Masanobu Kamitakahara and Toshiki Miyazaki

Journal of the Royal Society Interface Vol. 6 ( Suppl 3 ) page： S349-S360 2009.6

Synthesis of Bioactive HEMA-MPS-CaCl₂ Hybrid Gels: Effects of Catalysts in the Sol-Gel Processing on Mechanical Properties and in vitro Hydroxyapatite Formation in a Simulated Body Fluid Reviewed

Tomohiro Uchino, Chikara Ohtsuki, Masanobu Kamitakahara, Toshiki Miyazaki, Satoshi Hayakawa and Akiyoshi Osaka

Journal of Biomaterials Applications Vol. 23 page： 519-532 2009.5

Induced deposition of bone-like hydroxyapatite on thermally oxidized titanium substrates using a spatial gap in a solution that mimics a body fluid Reviewed

Atsushi Sugino, Kanji Tsuru, Satoshi Hayakawa, Koichi Kikuta, Giichiro Kawachi, Akiyoshi Osaka and Chikara Ohtsuki

Journal of the Ceramic Society of Japan Vol. 117 ( 4 ) page： 515-520 2009.4

化学ベクトルの制御に基づいた生体活性材料の創製 Reviewed

大槻主税, 宮崎敏樹

粉体および粉末冶金 Vol. 56 ( 4 ) page： 199-204 2009.4

Hybridization of Silver Nanoparticles on Hydroxyapatite in an Aqueous Solution Reviewed

Yuji Ichikawa, Shin-ichi Ogata, Tsukasa Torimoto, Giichiro Kawachi, Koichi Kikuta and Chikara Ohtsuki

Journal of the Ceramic Society of Japan Vol. 117 ( 1363 ) page： 294-298 2009.3

Apatite Formation Abilities and Mechanical Properties of Hydroxyethylmethacrylate-based Organic-inorganic Hybrids Incorporated with Sulfonic Groups and Calcium Ions Reviewed

Toshiki Miyazaki, Moriyoshi Imamura, Eiichi Ishida, Masahiro Ashizuka and Chikara Ohtsuki

Journal of Materials Science: Materials in Medicine Vol. 20 page： 157-161 2009.1

Effect of spatial design and thermal oxidation on apatite formation on Ti-15Zr-4Ta-4Nb alloy Reviewed

Atsushi Sugino, Chikara Ohtsuki, Kanji Tsuru, Satoshi Hayakawa, Takayoshi Nakano, Yoshimitsu Okazaki and Akiyoshi Osaka

Acta Biomaterialia Vol. 5 ( 1 ) page： 298-304 2009.1

Structure-Photodynamic Effect Relationships of 24 Glycoconjugated Photosensitizers in HeLa Cells Reviewed

Shiho HIROHARA, Makoto OBATA, Hiroki ALITOMO, Kohei SHARYO, Shin-ichi OGATA, Chikara OHTSUKI, Shigenobu YANO, Tsuyoshi ANDO, Masao TANIHARA

Biological & Pharmaceutical Bulletin Vol. 31 ( 12 ) page： 2265-2272 2008.12

Indirect selective laser sintering of apatite-wollstonite glass-ceramic Reviewed

K. Xiao, K. W. Dalgarno, D. I. Wood, R. D. Goodridge and C. Ohtsuki,

Proceedings of the Institution of Mechanical Engineers Vol. 222 ( Part H ) page： 1107-1114 2008.11

Behavior of Ceramic Biomaterials Derived from Tricalcium Phosphate in Physiological Condition Reviewed

Masanobu Kamitakahara, Chikara Ohtsuki, Toshiki Miyazaki

Journal of Biomaterials Applications Vol. 23 page： 197-212 2008.11

In vivo Response of Bioactive PMMA-based Bone Cement Modified with Alkoxysilane and Calcium Acetate Reviewed

Atsushi Sugino, Chikara Ohtsuki, Toshiki Miyazaki

Journal of Biomaterials Applications Vol. 23 page： 213-228 2008.11

生体組織を修復するためのセラミックスと金属材料

大槻主税

化学と教育 Vol. 56 ( 6 ) page： 250-253 2008.6

Apatite-forming ability of polyglutamic acid hydrogels in a body-simulating environment Reviewed

A. Sugino, T. Miyazaki and C. Ohtsuki

J. Mater. Sci.: Materials in Medicine Vol. 19 page： 2260-2274 2008.4

Biomimetic Coating of Hydroxyapatite Layer on Organic Substrates for Removal of Formaldehyde Reviewed

Takahiro KAWAI, Akari TAKEUCHI and Chikara OHTSUKI

Journal of Ecotechnology Research Vol. 13 ( 4 ) page： 283-286 2008.4

Preparation of bioactive spherical particles in the CaO-SiO₂ system through sol-gel processing under coexistence of poly(ethylene glycol) Reviewed

Ill Yong Kim, Giichiro Kawachi, Koichi Kikuta, Sung Baek Cho, Masanobu Kamitakahara and Chikara Ohtsuki

Journal of the European Ceramic Society Vol. 28 page： 1595–1602 2008.4

Relationship between apatite-forming ability and mechanical properties of bioactive PMMA-based bone cement modified with calcium salts and alkoxysilane Reviewed

Atsushi Sugino, Toshiki Miyazaki, Giichiro Kawachi, Koichi Kikuta and Chikara Ohtsuki

J. Mater. Sci.: Materials in Medicine Vol. 19 ( 3 ) page： 1399-1405 2008.3

空間デザインによるチタン系医用金属へのアパタイト形成能付与 Invited

都留寛治，杉野篤史，早川　聡，大槻主税，尾坂明義

PHOSPHRUS LETTER Vol. 61 page： 10-16 2008.3

Synthesis of octacalcium phosphate intercalated with dicaroboxylate ions from calcium carbonate and phosphoric acid Reviewed

Masanobu KAMITAKAHARA, Hiroaki OKANO, Masao TANIHARA and Chikara OHTSUKI

Journal of the Ceramic Society of Japan (J. Ceram. Soc. Japan) Vol. 116 ( 3 ) page： 481-485 2008.3

Surface Topography Designed to Provide Osteoconductivity to Ttitan ium after Thermal Oxidation Reviewed

Atsushi SUGINO, Keita UETSUKI, Kanji TSURU, Satoshi HAYAKAWA, Akiyoshi OSAKA and Chikara OHTSUKI

Materials Transactions Vol. 49 ( 3 ) page： 428-434 2008.3

Biomimetic deposition of hydroxyapatite on a synthetic polypeptide with β sheet structure in a solution mimicking body fluid Reviewed

Akari Takeuchi, Chikara Ohtsuki, Masanobu Kamitakahara, Shin-ichi Ogata, Toshiki Miyazaki and Masao Tanihara

J. Mater. Sci.: Materials in Medicine Vol. 19 ( 1 ) page： 387-393 2008.1

Formation of hydroxyapatite on ceramics consisting of tricalcium phosphate in a simulated body fluid Reviewed

Tomohiro UCHINO, Kohei YAMAGUCHI, Giichiro KAWACHI, Koichi KIKUTA, Masanobu KAMITAKAHARA and Chikara OHTSUKI

J. Ceram. Soc. Japan Vol. 116 ( 1 ) page： 96-99 2008.1

Evaluation of apatite-forming ability and mechanical property of pectin hydrogels Reviewed

Takashi ICHIBOUJI, Toshiki MIYAZAKI, Eiichi ISHIDA, Masahiro ASHIZUKA, Atsushi SUGINO, Chikara OHTSUKI and Kouichi KURAMOTO

J. Ceram. Soc. Japan Vol. 116 ( 1 ) page： 74-78 2008.1

Synthesis of ceramics in MO_n/2-SiO₂ systems through sol-gel processing under coexistence of polyethylene glycol and in vitro evalution of their bioactivity Reviewed

Ill-Yong KIM, Masanobu Kamitakahara, Giichiro KAWACHI, Koichi KIKUTA, Sung-Baek CHO and Chikara OHTSUKI

J. Ceram. Soc. Japan Vol. 116 ( 1 ) page： 56-62 2008.1

Apatite-forming ability of organic-inorganic hybrids fabricated from glucomannnan by chemical modification with alkoxysilane and calcium salt Reviewed

Yumi MORITA, Toshiki MIYAZAKI, Eiichi ISHIDA and Chikara OHTSUKI

J. Ceram. Soc. Japan Vol. 116 ( 1 ) page： 46-49 2008.1

Preparation of hydroxyapatite porous ceramics with different porous structures using a hydrothermal treatment with different aqueous solutions Reviewed

Masanobu KAMITAKAHARA, Chikara OHTSUKI, Giichiro KAWACHI, Deping Wang and Koji IOKU

J. Ceram. Soc. Japan Vol. 116 ( 1 ) page： 6-9 2008.1

Preparation of bioactive microspheres of organic modified calcium silicates through sol-gel processing Reviewed

Ill Yong Kim, Chikara Ohtsuki, Giichiro Kawachi, Masanobu Kamitakahara and Sung-Baek Cho

J. Sol-Gel Science and Technology Vol. 45 ( 1 ) page： 43-49 2008.1

Synthesis of Organic-inorganic Hybrids of Poly(Tetramethylene Oxide)-Calcium Silicate and in vitro Evaluation of Their Bioactivity Reviewed

Mi-Young KOH, Giichiro KAWACHI, Koichi KIKUTA, Masanobu KAMITAKAHARA and Chikara OHTSUKI

J. Ceram. Soc. Japan Vol. 115 ( 11 ) page： 732-737 2007.11

Synthesis of Calcium Phosphates Containing Metal Ions and Evaluation of their Catalytic Activity for the Decomposition of Hydrogen Peroxide Reviewed

Masanobu KAMITAKAHARA, Akio TAKAHASHI, Masao TANIHARA, Giichiro KAWACHI, Chikara OHTSUKI

Journal of the Ceramic Society of Japan Vol. 115 ( 7 ) page： 425-428 2007.7

Synthesis of Osteoconductive Organic-inorganic Nanohybrids through Modification of Chitin with Alkoxysilane and Calcium Chloride Reviewed

Toshiki Miyazaki, Chikara Ohtsuki, Masahiro Ashizuka

Journal of Biomaterials Applications Vol. 22 ( 1 ) page： 71-81 2007.7

In vitro apatite formation on polyamide containing carboxyl groups modified with silanol groups Reviewed

Takahiro Kawai, Chikara Ohtsuki, Masanobu Kamitakahara, Kayo Hosoya, Masao Tanihara, Toshiki Miyazaki, Yoshimitsu Sakaguchi and Shigeji Konagaya

Journal of Materials Science: Materials in Medicine Vol. 18 ( 6 ) page： 1037-1042 2007.6

Optical oxygen-sensing properties of porphyrin derivatives anchored on ordered porous aluminium oxide plates Reviewed

N. Araki, Y. Amao, T. Funabiki, M. Kamitakahara, C. Ohtsuki, K. Mitsuo, K. Asai, M. Obata and S. Yano

Photochem. Photobiol. Sci. Vol. 6 ( 7 ) page： 794-803 2007.5

Effects of Cross-linking Agent on Apatite-forming Ability and Mechanical Property of Organic-inorganic Hybrids Based on Starch Reviewed

T. Miyazaki, S. Yasunaga, E. Ishida, M. Ashizuka and C. Ohtsuki

Mater. Trans. Vol. 48 ( 3 ) page： 317-321 2007.3

Coating bone-like apatite onto organic substrates using solutions mimicking body fluid Reviewed

Chikara Ohtsuki, Masanobu Kamitakahara, Toshiki Miyazaki

Journal of Tissue Engineering and Regenerative Medicine Vol. 1 ( 1 ) page： 33-38 2007.1

Apatite-forming ability of micro-arc plasma oxidized layer of titanium in simulated body fluid Reviewed

Eungsun Byon, Yongsoo Jeong, Akari Takeuchi, Masanobu Kamitakahara and Chikara Ohtsuki

Surface & Coatings Technology Vol. 201 page： 5651-5654 2007

Sugar-dependent photodynamic effect of glycoconjugated porphyrins: A study on photocytotoxicity, photophysical properties and binding behaviro to bovine serum albumin (BSA) Reviewed

Makoto Obata, Shiho Hirohara, Kohei Sharyo, Hiroki Alitomo, Kazumi Kajiwara, Shin-ichi Ogata, Masao Tanihara, Chikara Ohtsuki, Shigenobu Yano

Biochimica et Biophysica Acta Vol. 1770 page： 1204-1211 2007

Design of novel bioactive materials through organic modification of calcium silicate Reviewed

Chikara Ohtsuki, Toshiki Miyazaki, Masanobu Kamitakahara and Masao Tanihara

Journal of the European Ceramic Society Vol. 27 page： 1527-1533 2007

Fabrication of poly(vinyl alcohol)-apatite hybrids through biomimetic process Reviewed

Caihong You, Toshiki Miyazaki, Eiichi Ishida, Masahiro Ashizuka, Chikara Ohtsuki and Masao Tanihara

Journal of the European Ceramic Society Vol. 27 page： 1585-1588 2007

Biological evaluation of an apatite-mullite glass-ceramic produced via selective laser sintering Reviewed

Ruth D Goodridge, David J Wood, Chikara Ohtsuki and Kenneth William Dalgarno

Acta Biomaterialia Vol. 3 page： 221-231 2007

Effect of Silane-Coupling Treatment on Thermal Decomposition of Octacalcium Phosphate Reviewed

Masanobu KAMITAKAHARA, Chikara OHTSUKI, Akio TAKAHASHI and Masao TANIHARA

Journal of The Society of Materials Science, Japan Vol. 55 ( 9 ) page： 881-884 2006.9

Hydroxyapatite-Forming Ability and Mechanical Properties of Organic-Inorganic Hybrids Reinforced by Calcium Phosphates Reviewed

Tomoshiro UCHINO, Chikara OHTSUKI, Masanobu KAMITAKAHARA, Masao TANIHARA and Toshiki MIYAZAKI

Journal of the Ceramic Society of Japan Vol. 114 ( 8 ) page： 692-696 2006.8

Preparation of Porous Glass-Ceramics Containing Whitlockite and Diopside for Bone Repair Reviewed

Masanobu KAMITAKAHARA, Chikara OHTSUKI, Yuko KOZAKA, Shin-ichi OGATA, Masao TANIHARA and Toshiki MIYAZAKI

J. Ceram. Soc. Japan Vol. 114 ( 1 ) page： 82-86 2006.1

Synthesis of Bioactive Organic-Inogaic Hybrids from Tetraisopropyl Titanate and Hydroxyethylemethacrylate Reviewed

Toshiki MIYAZAKI, Hiroko AKITA, Eiichi ISHIDA, Masahiro ASHIZUKA and Chikara OHTSUKI

J. Ceram. Soc. Japan Vol. 114 ( 1 ) page： 87-91 2006.1

Apatite Formation on CaO,SiO₂-Based Glass-Ceramics in a Simulated Body Fluid Reviewed

Masanobu Kamitakahara,Chikara Ohtsuki

Phosphorus Research Bullitin Vol. 20 page： 101-110 2006

Sugar-dependent aggregation of glycoconjugated chlorins and its effect on photocytotoxicity in HeLa cells Reviewed

Shiho Hirohara, Makoto Obata, Shin-ichi Ogata, Kazumi Kajiwara, Chikara Ohtsuki, Masao Tanihara, Shigenobu Yano

Journal of Photochemistry and Photobiology, B: Biology Vol. 84 ( 1 ) page： 56-63 2006

Effect of ZnO Addition on Bioactive CaO-SiO₂-P₂O₅-CaF₂ Glass-Ceramics Containing Apatite and Wollastonite Reviewed

M. Kamitakahara, C. Ohtsuki, H. Inada, M. Tanihara and T. Miyazaki

Acta Biomaterialia Vol. 2 ( 4 ) page： 467-471 2006

Mechanical and histological evaluation of a PMMA-based bone cement modified with g-methacryloxypropyltrimethoxysilane and calcium acetate Reviewed

Tadashi Tsukeoka, Masahiko Suzuki, Chikara Ohtsuki, Atsushi Sugino, Yoshikazu Tsuneizumi, Jin Miyagi, Kouichi Kuramoto and Hideshige Moriya

Biomaterials Vol. 27 page： 3897-3903 2006

Repair of 20-mm long rabbit radial bone defects using BMP-derived peptide combined with an a-tricalcium phosphate scaffold Reviewed

Atsuhiro Saito, Yoshihisa Suzuki, Makoto Kitamura, Shin-Ichi Ogata, Yusuke Yoshihara, Singo Masuda, Chikara Ohtsuki and Masao Tanihara

J. Biomed. Mater. Res. Vol. 77A page： 700-706 2006

Removal of formaldehyde by hydroxyapatite layer biomimetically deposited on polyamide film Reviewed

Takahiro Kawai, Chikara Ohtsuki, Masanobu Kamitakahara, Masao Tanihara, Toshiki Miyazaki, Yoshimitsu Sakaguchi, Shigeji Konagaya,

Environ. Sci. Tech. Vol. 40 page： 4281-4285 2006

APATITE FORMATIONON CaO,SiO₂-BASED GLASS-CERAMICS IN A SIMULATED BODY FLUID Reviewed

Phosphorus Research Bulletin Vol. 20 page： 101-110 2006

Porous Calcium Phospahte with Biomodal Distribution by Chemical Treatment of Macroprous α-TCP

C. Ohtsuki, M. Kitamura, S. Ogata, M. Kamitakhara, M. Tanihara and T. Miyazaki

Archives of BioCeramics Research Vol. 5, ed. by F. Watari, T. Akazawa, M. Uo and T. Akasaka page： 328-33 2005.10

Mesoporous Calcium Phosphate Via Post-Treatment of α-TCP Reviewed

Makoto Kitamura, Chikara Ohtsuki, Shin-ichi Ogata, Masanobu Kamitakahara, Masao Tanihara and Toshiki Miyazaki

J. Am. Ceram. Soc. Vol. 88 ( 4 ) page： 822-826 2005.4

Thermosensitive Gel Formation of Novel Polypeptides Containing a Collagen-Derived Pro-Hyp-Gly Sequence and an Elastin-Derived Val-Pro-Gly-Val-Gly Sequence Reviewed

Yasushi Morihara, Shin-ichi Ogata, Masanobu Kamitakahara, Chikara Ohtsuki and Masao Tanihara

J. Polym. Sci. Part A: Polym. Chem. Vol. 43 page： 6048-6056 2005

Cellular uptake and photocytotoxicity of glycoconjugated chlorins in HeLa cells Reviewed

Shiho Hirohara, Makoto Obata, Shin-ichi Ogata, Chikara Ohtsuki, Suguru Higashida, Shun-ichiro Ogura, Ichiro Okura, Makiko Takenaka, Hiroshi Ono, Yuko Sugai, Yuji Mikata, Masao Tanihara and Shigenobu Yano

J. Photochem. Photobiol. B: Biology Vol. 78 page： 7-15 2005

Accelerated bone repair with the use of a synthetic BMP-2-derived peptide and bone-marrow stromal cells Reviewed

Atsuhiro Saito, Yoshihisa Suzuki, Shin-ichi Ogata, Chikara Ohtsuki and Masao Tanihara

J. Biomed. Mater. Res. Vol. 72A page： 77-82 2005

Bonelike .. A/ PLGA hybrid materials for bone regeneration: Preparation route and physicochemical characterisation Reviewed

J. M. OLIVEIRA, T. MIYAZAKI, M. A. LOPES, C. OHTSUKI and J. D. SANTOS

J. Mater. Sci.: Materials in Medicine Vol. 16 ( 3 ) page： 253-259 2005

Control of the microstructure of porous tricalcium phosphate: Effects of addition of Mg, Zn and Fe Reviewed

Masanobu Kamitakahara, Chikara Ohtsuki, Makoto Oishi, Shin-ichi Ogata, Masao Tanihara and Toshiki Miyazaki

J. Jpn. Soc. Powder Powder Metallury Vol. 52 ( 5 ) page： 356-359 2005

デンプンを用いた生体活性有機－無機ハイブリッドの創成 Reviewed

宮崎敏樹, 安永尚司, 石田英一, 芦塚正博, 大槻主税

粉体および粉末冶金 Vol. 52 ( 5 ) page： 360-363 2005

Synthesis of Poly(isobutyl methacrylate-co-2,2,2-trifluoroethyl methacrylate) having Tetraphenylporphinato Platinum(II) Moiety as an Oxygen-Sensing Dye forPressure Sensitive Paint (PSP) Reviewed

M. Obata, Y. Tanaka, N. Araki, S. Yano, M. Harada, K. Mitsuo, K. Asai, T. Kakuchi, C. Ohtsuki

J. Polym. Sci. Pol. Chem. Vol. 43 ( 14 ) page： 2997-3006 2005

Synthesis of Bioactive PMMA Bone Cement viaModification with Methacryloxypropyltrimethoxysilane and Calcium Acetate Reviewed

Akiko Mori, Chikara Ohtsuki, Toshiki Miyazaki, Atsushi Sugino, Masao Tanihara, Koichi Kuramoto and Akiyoshi Osaka

J. Mater. Sci.: Materials in Medicine Vol. 16 ( 8 ) page： 713-718 2005

Synthesis and insulin-mimetic activities of metal complexes with 3-hydroxypyridine-2-carboxylic acid Reviewed

Misaki Nakai, Fumi Sekiguchi, Makoto Obata, Chikara Ohtsuki, Yusuke Adachi, Hiromu Sakurai, Chris Orvig, Dieter Rehder and Shigenobu Yano

J. Inorganic Biochemistry Vol. 99 page： 1275-1282 2005

Heterogeneous nucleation of hydroxyapatite on protein: Structural effect of silk sericin Reviewed

Akari TAKEUCHI, Chikara OHTSUKI, Toshiki MIYAZAKI, Masanobu KAMITAKAHARA, Shin-ichi OGATA, Masao YAMAZAKI, Yoshiaki FURUTANI, Hisao KINOSHITA and Masao TANIHARA

Journal of The Royal Society Interface Vol. 2 page： 373-378 2005

A Comparative Study of Apatite Deposition on Polyamide Films containing Different Functional Groups under a Biomimetic Condition Reviewed

Takahiro KAWAI, Chikara OHTSUKI, Masanobu KAMITAKAHARA, Masao TANIHARA, Toshiki MIYAZAKI, Yoshimitsu SAKAGUCHI, Shigeji KONAGAYA

J. Ceram. Soc. Japan Vol. 113 page： 588-592 2005

A Composite of Hydroxyapatite withElectrospun Biodegradable Nanofibers as a Tissue Engineering Material Reviewed

Yoshihiro Ito, Hirokazu Hasuda, Masanobu Kamitakahara, Chikara Ohtsuki, Masao Tanihara, Inn-Kyu Kang, Oh Hyeong Kwon

J. Bioscience and Bioengineering Vol. 100 ( 1 ) page： 43-49 2005

Synthesis of Poly(Pro-Hyp-Gly)n by Direct Polycondensation of (Pro-Hyp-Gly)n, Where n= 1, 5, 10, and Stability of theTriple-Helical Structure Reviewed

Takahiro Kishimoto, Yasushi Morihara, Michinori Osanai, Shin-ichi Ogata, Masanobu Kamitakahara, Chikara Ohtsuki and Masao Tanihara

Biopolymers Vol. 79 page： 163-172 2005

化学ベクトルの制御による骨修復用ガラス材料の設計

大槻主税, 上高原理暢, 宮崎敏樹

マテリアルインテグレーション page： 7-11 2005

Fabrication of polyglutamic acid-hydrxyapatite hybrid through biomimetic process

A. Sugino, T. Miyazaki, C. Ohtsuki, M. Tanihara and K. Kuramoto

Archives of BioCeramics Research Vol. 5, ed. by F. Watari, T. Akazawa, M. Uo and T. Akasaka, page： 230-233 2005

擬似体液を用いる水酸アパタイトの合成

大槻主税

ナノマテリアルハンドブック, 国武豊喜監修, エヌ・ティー・エス page： 785-788 2005

セラミックスの生体機能

大槻主税

実力養成化学スクール　セラミックス材料化学, 日本化学会編, 北条純一責任編集, 丸善， page： 117-133 2005

擬似体液を利用したバイオミメティックプロセス

大槻主税

粉体および粉末冶金 Vol. 52 ( 5 ) page： 373-378 2005

リン酸三カルシウム多孔体の生体吸収性の制御

大槻主税, 上高原理暢,

Phosphorus Letter ( 53 ) page： 20-27 2005

骨組織の自己再生を支援するセラミックスの材料設計

大槻主税, 上高原理暢, 宮崎敏樹

セラミックス Vol. 40 ( 10 ) page： 862-864 2005

In Vitro Aging Test for Bioactive PMMA-Based Bone Cement Using Simulated Body Fluid

S.B. Cho, S.B. Kim, K.J. Cho, I.Y. Kim, C. Ohtsuki and M. Kamitakahara

Bioceramics, Vol. 17 (Key Engineering Materials, Vol. 284-286), ed. by Panjian Li, Kai Zhang and Clifford W. Colwell, Jr., Trans Tech Publications Ltd., Switzerland page： 153-156 2005

Preparation of Porous Biphasic Tricalcium Phosphate and Its In Vivo Behavior Reviewed

M. Kamitakahara, C. Ohtsuki, M. Oishi, S. Ogata, T. Miyazaki and M. Tanihara

Bioceramics, Vol. 17 (Key Engineering Materials, Vol. 284-286), ed. by Panjian Li, Kai Zhang and Clifford W. Colwell, Jr., Trans Tech Publications Ltd., Switzerland page： 281-284 2005

Biodegradation of Porous Alpha-Tricalcium Phosphate Coated with Silk Sericin Reviewed

Akari Takeuchi, Chikara Ohtsuki, Masanobu Kamitakahara, Shin-ichi Ogata, Masao. Tanihara, Toshiki Miyazaki, Masao Yamazaki, Yoshiaki Furutani and Hisao Kinoshita

Bioceramics, Vol. 17 (Key Engineering Materials, Vol. 284-286), ed. by Panjian Li, Kai Zhang and Clifford W. Colwell, Jr., Trans Tech Publications Ltd., Switzerland page： 329-332 2005

In Vitro Analysis of Proteins Adhesion to Phase Pure Hydroxyapatite and Silicon Substituted Hydroxyapatite Reviewed

C.M. Botelho, R.A. Brooks, T. Kawai, S. Ogata, C. Ohtsuki, SM. Best, M.A. Lopes, J.D. Santos, N. Rushton and W. Bonfield

Bioceramics, Vol. 17 (Key Engineering Materials, Vol. 284-286), ed. by Panjian Li, Kai Zhang and Clifford W. Colwell, Jr., Trans Tech Publications Ltd., Switzerland page： 461-464 2005

Apatite Deposition on Organic-inorganic Hybrids Synthesized from Poly(Vinyl Alcohol) and Various Metal Oxides Reviewed

Caihong You, Toshiki Miyazaki, Eiichi Ishida, Masahiro Ashizuka, Chikara Ohtsuki and Masao Tanihara

Bioceramics, Vol. 17 (Key Engineering Materials, Vol. 284-286), ed. by Panjian Li, Kai Zhang and Clifford W. Colwell, Jr., Trans Tech Publications Ltd., Switzerland page： 469-472 2005

Apatite Deposition on Polyamide Film Containing Silanol Groups in Simulated Body Environment Reviewed

T. Kawai, C. Ohtsuki, M. Kamitakahara, M. Tanihara, T. Miyazaki, Y. Sakaguchi and S. Konagaya

Bioceramics, Vol. 17 (Key Engineering Materials, Vol. 284-286), ed. by Panjian Li, Kai Zhang and Clifford W. Colwell, Jr., Trans Tech Publications Ltd., Switzerland page： 505-508 2005

Apatite Formation on Organic-Inorganic Hybrid Containing Sulfonic Group Reviewed

Toshiki Miyazaki, Moriyoshi Imamura, Eiichi Ishida, Masahiro Ashizuka, Chikara Ohtsuki and Masao Tanihara

Bioceramics, Vol. 17 (Key Engineering Materials, Vol. 284-286), ed. by Panjian Li, Kai Zhang and Clifford W. Colwell, Jr., Trans Tech Publications Ltd., Switzerland page： 725-728 2005

Synthesis of Biodegradable Hybrid Consisting of Hydroxyapatite and Alginate Reviewed

C. Ohtsuki, K. Hosoya, T. Kawai, M. Kamitakahara, S. Ogata, T. Miyazaki and M. Tanihara

Bioceramics, Vol. 17 (Key Engineering Materials, Vol. 284-286), ed. by Panjian Li, Kai Zhang and Clifford W. Colwell, Jr., Trans Tech Publications Ltd., Switzerland, page： 779-782 2005

Development of bioactive glass-ceramics for use with the selective laser sintering (SLS) process

R. G. Goodridge, C. Ohtsuki, M. Kamitakahara, K. W. Dalgarno and D. J. Wood

Archives of BioCeramics Research Vol. 5, ed. by F. Watari, T. Akazawa, M. Uo and T. Akasaka page： 43-46 2005

Apatite-forming ability of organic-inorganic hybrids prepared from poly(vinyl alcohol) by modification with metal hydroxides and calcium salt

C. You, T. Miyazaki, E. Ishida, M. Ashizuka and C. Ohtsuki

Archives of BioCeramics Research Vol. 5, ed. by F. Watari, T. Akazawa, M. Uo and T. Akasaka page： 91-94 2005

Preparation of organic-inorganic hybrids consisting of apatite and pectin

T. Ichibouji, T. Miyazaki, E. Ishida, M. Ashizuka, A. Sugino, C. Ohtsuki and K. Kuramoto

Archives of BioCeramics Research Vol. 5, ed. by F. Watari, T. Akazawa, M. Uo and T. Akasaka page： 95-98 2005

Reinforcement of a-TCP porous body with organic-inorganic hybrids

T. Uchino, C. Ohtsuki, M. Kamitakhara, M. Tanihara and T. Miyazaki

Archives of BioCeramics Research Vol. 5, ed. by F. Watari, T. Akazawa, M. Uo and T. Akasaka page： 130-133 2005

Hydroxyapatite deposition on Collagen-like Polypeptide Modified with Silanol Groups

M. Kamitakhara, C. Ohtsuki, Y. Morihara, S. Ogata and M. Tanihara

Archives of BioCeramics Research Vol. 5, ed. by F. Watari, T. Akazawa, M. Uo and T. Akasaka page： 210-213 2005

2004年の化学　注目の論文：バイオミメティックな手法で細胞が好む表面をつくる

大槻主税

化学 Vol. 59 ( 12 ) page： 69-70 2004.11

体液環境下における生体活性材料表面でのアパタイト析出

大槻主税, 上高原理暢

日本結晶成長学会誌 Vol. 31 ( 2 ) page： 69-72 2004.7

骨と結合する人工骨における傾斜構造

大槻主税，宮崎敏樹

粉体および粉末冶金 Vol. 51 ( 4 ) page： 219-225 2004.4

A novel covalently crosslinked gel of alginate and silane with the ability to form bone-like apatite Reviewed

Kayo Hosoya, Chikara Ohtsuki, Takahiro Kawai, Masanobu Kamitakahara, Shin-ichi Ogata, Toshiki Miyazaki and Masao Tanihara

J. Biomed. Mater. Res Vol. 71A page： 596-601 2004

Bioactivity of MgO-CaO-SiO₂ Porous Glass-Ceramics Reviewed

Chikara OHTSUKI, Toshiki MIYAZAKI, Kikuka KISHIRO, Masanobu KAMITAKAHARA and Masao TANIHARA

J. Ceram. Soc. Japan, Suppl. Vol. 112 page： S809-S812 2004

DESIGN OF A NOVEL BIOACTIVE CALCIUMPHOSPHATE PASTE CONTAINING ACETYL CELLULOSE Reviewed

Takahiro Kawai, Chikara Ohtsuki, Hirofumi Inada, Masanobu Kamitakahara,Masao Tanihara and Toshiki Miyazaki

Phosphorus Research Bulletin Vol. 17 page： 203-208 2004

Synthesis, structural characterization, and antitumor activity of palladium(II) complexes containing a sugar unit Reviewed

Izabela Brudzinska, Yuji Mikata, Makoto Obata, Chikara Ohtsuki and Shigenobu Yano

Bioorganic & Medicinal Chemistry Letters Vol. 14 page： 2533-2536 2004

Prolonged ectopic calcification induced by BMP-2-derived synthetic peptide Reviewed

Atsuhiro Saito, Yoshihisa Suzuki, Shin-ichi Ogata, Chikara Ohtsuki and Masao Tanihara

J. Biomed. Mater. Res. Vol. 70A page： 115-121 2004

細孔構造が制御されたa 型リン酸三カルシウムセラミックス多孔体の合成 Reviewed

北村真, 大槻主税, 尾形信一, 上高原理暢, 谷原正夫, 宮崎敏樹

材料 Vol. 53 page： 594-598 2004

*The controlled resorption of porous a-tricalcium phosphate using a hydroxypropylcellulose coating Reviewed

Makoto KITAMURA, Chikara OHTSUKI, Haruna IWASAKI, Shin-ichi OGATA, Masao TANIHARA and Toshiki MIYAZAKI

J. Mater. Sci.: Materials in Medicine Vol. 15 page： 1153-1158 2004

Cellular Uptake and Photocytotoxicity of Glycoconjugated Porphyrins in HeLa Cells Reviewed

Shiho Hirohara, Makoto Obata, Atsuhiro Saito, Shin-ichi Ogata, Chikara Ohtsuki, Suguru Higashida, Shun-ichiro Ogura, Ichiro Okura, Yuko Sugai, Yuji Mikata, Masao Tanihara,Shigenobu Yano

Photochemistry and Photobiology Vol. 80 page： 301-308 2004

FABRICATION AND CHEMICAL DURABILITY OF POROUS BODIES CONSISTING OF BIPHASIC TRICALCIUM PHOSPHATES Reviewed

Makoto Oishi, Chikara Ohtsuki, Makoto Kitamura, Masanobu Kamitakahara, Shin-ichi Ogata, Toshiki Miyazaki and Masao Tanihara

Phosphorus Research Bulletin Vol. 17 page： 95-100 2004

Microstructure and Bioresorbable Properties of a-TCP Ceramic Porous Body Fabricated by Direct Casting Method Reviewed

Makoto Kitamura, Chikara Ohtsuki, Shin-ichi Ogata, Masanobu Kamitakahara and Masao Tanihara

Materials Transactions Vol. 45 page： 983-988 2004

Coating of an apatite layer on polyamide films containing sulfonic groups by a biomimetic process Reviewed

Takahiro Kawai, Chikara Ohtsuki, Masanobu Kamitakahara, Toshiki Miyazaki, Masao Tanihara, Yoshimitsu Sakaguchi and Shigeji Konagaya

Biomaterials Vol. 25 page： 4529-4534 2004

Formation of Octacalcium Phosphate from an a-TCP Porous Body Reviewed

Makoto KITAMURA, Chikara OHTSUKI, Shin-ichi OGATA, Masanobu KAMITAKAHARA and Masao TANIHARA

J. Ceram. Soc. Japan, Suppl. Vol. 112 page： S817-S821 2004

Graded Structure on Bone-Bonding Metal Induced by Chemical Surface Modification Reviewed

T. MIYAZAKI, H.-M. KIM, T. KOKUBO, C. OHTSUKI and M. ASHIZUKA

J. Ceram. Soc. Japan, Suppl. Vol. 112 page： S848-S852 2004

Fabrication of Bioactive Glass-Ceramics Containing Zinc Oxide Reviewed

C. Ohtsuki, H. Inada, M. Kamitakahara, M. Tanihara and T. Miyazaki

Bioceramics, Vol. 16 (Key Engineering Materials Vols. 254-256), ed. by M. A. Barbosa, F. J. Monteiro, R. Correia and B. Leon, Trans Tech Publications Ltd. ( 16 ) page： 59-62 2004

Preparation and characterization of Zn-releasing bioactive glasses

Y.J. Choi, S.B. Cho, I.Y. Kim, S.B. Kim, J.O. Kim and C. Ohtsuki

Archives of BioCeramics Research Vol. 4, ed. by Byong-Taek Lee, Ho-Yeon Song and Hae-Hyoung Lee page： 322-324 2004

Effect of particle size and shape of inorganic filler on mechanical property of organic/inorganic composite

S.B. Cho, S.B. Kim, I.Y. Kim, C. Ohtsuki and M. Kamitakahara

Archives of BioCeramics Research Vol. 4, ed. by Byong-Taek Lee, Ho-Yeon Song and Hae-Hyoung Lee page： 138-141 2004

Synthesis of bioactive organic-inorganic hybrids prepared from starch by modification with alkoxysilane and calcium salt: effect of calcium salt

Toshiki Miyazaki, Shouji Yasunaga, Eiichi Ishida, Masahiro Ashizuka, Chikara Ohtsuki and Masao Tanihara

Archives of BioCeramics Research Vol. 4, ed. by Byong-Taek Lee, Ho-Yeon Song and Hae-Hyoung Lee page： 125-128 2004

Reinforcement of α-tricalcium phosphate porous body with organic-inorganic hybrids consisting of 2-hydroxyethylmethacrylate and 3-methacryloxypropyltrimethoxysilane

Tomohiro Uchino, Chikara Ohtsuki, Masanobu Kamitakahara, Msao Tanihara and Toshiki Miyazaki

Archives of BioCeramics Research Vol. 4, ed. by Byong-Taek Lee, Ho-Yeon Song and Hae-Hyoung Lee page： 74-77 2004

Preparation of bioactive glass-ceramics containing tricalcium phosphate and diopside

Masahobu Kamitakahara, Yuko Kozaka, Chikara Ohtsuki and Masao Tanihara

Archives of BioCeramics Research Vol. 4, ed. by Byong-Taek Lee, Ho-Yeon Song and Hae-Hyoung Lee page： 70-73 2004

Setting behavior and mechanical properties of bioactive paste composed of calcium phosphates and acetyl cellulose

Chikara Ohtsuki, Takahiro Kawai, Hirofumi Inada, Masanobu Kamitakahara, Toshiki Miyazaki and Masao Tanihara

Archives of BioCeramics Research Vol. 4, ed. by Byong-Taek Lee, Ho-Yeon Song and Hae-Hyoung Lee page： 39-42 2004

Preparation of bioactive organic-inorganic hybrids from poly(vinyl alcohol) by modification with various metal oxides and calcium salt

Caihong You, Toshiki Miyazaki, Eiichi Ishida, Masahiro Ashizuka, Chikara Ohtsuki and Masao Tanihara

Archives of BioCeramics Research Vol. 4, ed. by Byong-Taek Lee, Ho-Yeon Song and Hae-Hyoung Lee page： 35-38 2004

Synthesis of bioactive organic-inorganic hybrids containing sulfonic group

Moriyoshi Imamura, Toshiki Miyazaki, Eiichi Ishida, Masahiro Ashizuka, Chikara Ohtsuki and Masao Tanihara

Archives of BioCeramics Research Vol. 4, ed. by Byong-Taek Lee, Ho-Yeon Song and Hae-Hyoung Lee page： 31-34 2004

Synthesis of Flexible Bioactive Materials by Modification of HEMA with Silanol Groups and Calcium Ions

M. Kamitakahara, C. Ohtsuki, T. Uchino, M. Tanihara and T. Miyazaki

Transactions of 7th World Biomaterials Congress page： 1767 2004

Formation of Mesopores from Alpha-TCP Porous Bodies and their Characteristics of Protein Adsorption

M. Kitamura, C. Ohtsuki, S. Ogata, M. Kamitakahara and M. Tanihara

Transactions of 7th World Biomaterials Congress page： 1478 2004

Bonelike Apatite Formation on Synthetic Polymers Coated with Titanium Oxide

F. Balas, M. Kawashita, C. Ohtsuki, H.-M. Kim, T. Kokubo and T. Nakamura

Transactions of 7th World Biomaterials Congress page： 1468 2004

Compositional Dependence of Apatite Formation for PMMA-based Bone Cement

S.B. Cho, S.B. Kim, K.J. Cho, C. Ohtsuki and M. Kamitakahara

Transactions of 7th World Biomaterials Congress page： 1456 2004

Fabrication of a Bioactive Calcium Phosphate Paste with Cellulose Acetate

T. Kawai, C. Ohtsuki, T. Miyazaki, H. Inada, M. Kamitakahara and M. Tanihara

Transactions of 7th World Biomaterials Congress page： 997 2004

Apatite-Formation on Alginate Gels Modified with Silanol Groups: An Approach toward Alginate-Apatite Hybrids

C. Ohtsuki, K. Hosoya, M. Kamitakahara, S. Ogata, M. Tanihara and T. Miyazaki

Transactions of 7th World Biomaterials Congress page： 668 2004

Apatite-forming Ability of Organic-inorganic Hybrids Synthesized from Hydroxyethylmethacrylate and Titanium Alkoxide

T. Miyazaki, H. Akita, E. Ishida, M. Ashizuka, C. Ohtsuki and M. Tanihara

Transactions of 7th World Biomaterials Congress page： 667 2004

Bonelike/PLGA Hybrid Materials for Bone Regeneration: In Vivo Evaluation Reviewed

J. M. Oliveira, T. Kawai, M. A. Lopes, C. Ohtsuki, J. D. Santos and A. Afonso

Advanced Materials Forum II, Vol.455-456, ed. by Rodrigo Martins, Elvira Fortunator, Isabel Ferreira and Carlos Dias, Trans Tech Publications Inc. page： 374-378 2004

Novel molybdenum-based bioactive materials

Toshiki Miyazaki, Go Wakabayashi, Eiichi Ishida, Masahiro Ashizuka, Tadashi Kokubo and Chikara Ohtsuki

Proceedings of the Workshop on Biomechanical Engineering and Biomaterials, International Symposium on Bio-inspired Systems (ISBS2004), Kyushu Institute of Technology page： 36-39 2004

Mechanical properties and apatite-forming ability of organic-inorganic hybrids prepared from 2-hydroxyethylmethacrylate and 3-methacryloxypropyltrimethoxysilane

Tomohiro Uchino, Chikara Ohtsuki, Masanobu Kamitakahara, Masao Tanihara and Toshiki Miyazaki

Proceedings of the Workshop on Biomechanical Engineering and Biomaterials, International Symposium on Bio-inspired Systems (ISBS2004), Kyushu Institute of Technology page： 28-31 2004

In vitro transformation of porous biphasic tricalcium phosphate into octacalcium phosphate and hydroxyapatite

Makoto Oishi, Chikara Ohtsuki, Masanobu Kamitakahara, Shin-ichi Ogata, Masao Tanihara and Toshiki Miyazak

Proceedings of the Workshop on Biomechanical Engineering and Biomaterials, International Symposium on Bio-inspired Systems (ISBS2004), Kyushu Institute of Technology page： 24-27 2004

Fabrication of α-Tricalcium Phosphate Porous Body Having a Uniform Pore Size Distribution Reviewed

M. Kitamura, C. Ohtsuki, S. Ogata, M. Kamitakahara and M. Tanihara

Bioceramics, Vol. 16 (Key Engineering Materials Vols. 254-256), ed. by M. A. Barbosa, F. J. Monteiro, R. Correia and B. Leon, Trans Tech Publications Ltd. ( 16 ) page： 965-968 2004

In Vivo behaviour of Bonelike/PLGA Hybrid: Histological Analysis and Peripheral Quantitative Computed Tomography (pQ-CT) Evaluation Reviewed

J. M. Oliveira, T. Kawai, M. A. Lopes, C. Ohtsuki, J. D. Santos and A. Afonso

Bioceramics, Vol. 16 (Key Engineering Materials Vols. 254-256), ed. by M. A. Barbosa, F. J. Monteiro, R. Correia and B. Leon, Trans Tech Publications Ltd. ( 16 ) page： 565-568 2004

Apatite Deposition on Organic-inorganic Hybrids Prepared from Chitin by Modification with Alkoxysilnae and Calcium Salt Reviewed

T. Miyazaki, C. Ohtsuki, M. Tanihara and M Ashizuka

Bioceramics, Vol. 16 (Key Engineering Materials Vols. 254-256), ed. by M. A. Barbosa, F. J. Monteiro, R. Correia and B. Leon, Trans Tech Publications Ltd. ( 16 ) page： 545-548 2004

Effect of Sulfonic Group and Calcium Content on Apatite-Forming Ability of Polyamide Films in a Solution Mimicking Body Fluid Reviewed

T. Miyazaki, C. Ohtsuki, M. Tanihara and M Ashizuka

Bioceramics, Vol. 16 (Key Engineering Materials Vols. 254-256), ed. by M. A. Barbosa, F. J. Monteiro, R. Correia and B. Leon, Trans Tech Publications Ltd. ( 16 ) page： 525-528 2004

Apatite-Forming Ability and Mechanical Properties of Poly(tetramethylene oxide) (PTMO)-TO5 Hybrids Reviewed

M. Kamitakahara, M. Kawashita, N. Miyata, H.-M. Kim, T. Kokubo, C. Ohtsuki and T. Nakamura

Bioceramics, Vol. 16 (Key Engineering Materials Vols. 254-256), ed. by M. A. Barbosa, F. J. Monteiro, R. Correia and B. Leon, Trans Tech Publications Ltd. ( 16 ) page： 521-524 2004

Bonelike Apatite Formation on Synthetic Organic Polymers Coated with TiO₂ Reviewed

F. Balas, M. Kawashita, H. M. Kim, C. Ohtsuki, T. Kokubo and T. Nakamura

Bioceramics, Vol. 16 (Key Engineering Materials Vols. 254-256), ed. by M. A. Barbosa, F. J. Monteiro, R. Correia and B. Leon, Trans Tech Publications Ltd. ( 16 ) page： 467-470 2004

Apatite Deposition on Silk Sericin in a solution Mimicking Extracellular Fluid: Effects of Fabrication Process of Sericin Film Reviewed

Akari Takeuchi, Chikara Ohtsuki, Masanobu Kamitakahara, Shin-ichi Ogata, Masao Tanihara, Masao Yamazaki, Toshiki Miyazaki, Yoshiaki Furutani and Hisao Kinoshita

Bioceramics, Vol. 16 (Key Engineering Materials Vols. 254-256), ed. by M. A. Barbosa, F. J. Monteiro, R. Correia and B. Leon, Trans Tech Publications Ltd. ( 16 ) page： 403-406 2004

Development of Novel PMMA-Based Cement Reinforced by Bioactive CaO-SiO₂ Gel Powder Reviewed

S. B. Cho, S. B. Kim, K. J. Cho, C. Ohtsuki and T. Miyazaki

Bioceramics, Vol. 16 (Key Engineering Materials Vols. 254-256), ed. by M. A. Barbosa, F. J. Monteiro, R. Correia and B. Leon, Trans Tech Publications Ltd. ( 16 ) page： 285-288 2004

Preparation of Bioactive Glass-ceramics in ZnO-CaO-SiO₂-P₂O₅-CaF₂System Reviewed

Masanobu Kamitakahara, Chikara Ohtsuki, Hirofumi Inada, Masao Tanihara and Toshiki Miyazaki

XX International Congress on Glass Proceedings, ed. by Toshinobu Yoko, XXICG Congress Committee, The Ceramic Society of Japan page： O-12-002 2004

CONTROL OF HYDROXYAPATITE DEPOSITION ON ORGANIC POLYMER UNDER BIOMIMICKING CONDITION

Chikara Ohtsuki, Takahiro Kawai and Masanobu Kamitakahara,

Phosphorous Research Bulletin Vol. 17 page： 21-28 2004

DESIGN OF BONE-BONDING ORGANIC-INORGANIC HYBRIDS

Toshiki Miyazaki and Chikara Ohtsuki

Phosphorous Research Bulletin Vol. 17 page： 59-66 2004

CONTROL OF HYDROXYAPATITE DEPOSITION ON ORGANIC POLYMER UNDER BIOMIMICKING CONDITION Reviewed

Chikara Ohtsuki, Takahiro Kawai and Masanobu Kamitakahara

Phosphorous Research Bulletin ( 17 ) page： 21-28 2004

DESIGN OF BONE-BONDING ORGANIC-INORGANIC HYBRIDS Reviewed

Toshiki Miyazaki and Chikara Ohtsuki

Phosphorous Research Bulletin ( 17 ) page： 59-66 2004

Control of Bioresorption of Porous alpha-Tricalcium Phosphate Reviewed

Toshiki Miyazaki, Chikara Ohtsuki, Akari Takeuchi, Masahobu Kamitakahara, Shin-ichi Ogata, Masao Tanihara, Hiromi Tanaka, Yoshiaki Furutani and Hisao Kinoshita

Transactions of the Materials Research Society of Japan (Trans. MRS-J) Vol. 29 ( 6 ) page： 2923-2926 2004

Coating of Bone-like Apatite Layer on Organic Polymers Using a Solution Mimicking Body Fluid

Chikara Ohtsuki

Proceedings of 4th Asian International Symposium on Biomaterials (AISB4) and 2nd International Symposium on Fusion of Nano and Bio Technologies (FNB2004) page： 123-125 2004

Composite of Biodegradable Nanofiber with Hydroxyapatite

Yoshihiro Ito, Hirokazu Hasuda, Masanobu Kamitakahra, Chikara Ohtsuki, Masao Tanihara, Oh Hyeong Kwon and Inn-Kyu Kang

Proceedings of 4th Asian International Symposium on Biomaterials (AISB4) and 2nd International Symposium on Fusion of Nano and Bio Technologies (FNB2004) page： 180 2004

Development of Bioactive Paste with Improved Handling Reviewed

Chikara Ohtsuki, Toshiki Miyazaki, Hirofumi Inada, Masanobu Kamitakahara and Masao Tanihara

Transactions of the Materials Research Society of Japan (Trans. MRS-J) Vol. 29 ( 8 ) page： 3327-3330 2004

DESIGN OF BIOACTIVE ORGANIC-INORGANIC HYBRIDS ON THE BASIS OF BONDING MECHANISM OF CALCIUM SILICATE GLASS WITH LIVING BONE Reviewed

Chikara OHTSUKI, Masanobu KAMITAKAHARA and Toshiki MIYAZAKI

Ann. Chim. Sci. Mat. Vol. 29 ( 1 ) page： 29-39 2004

Fabrication of Porous Bioactive Glass-ceramics in MgO-CaO-SiO₂ System Reviewed

Chikara Ohtsuki, Masanobu Kamitakahara, Kikuka Kishiro, Masao Tanihara and Toshiki Miyazak

XX International Congress on Glass Proceedings, ed. by Toshinobu Yoko, XXICG Congress Committee, The Ceramic Society of Japan page： O-12-003 2004

生体活性セラミックスの現状と展望 Invited Reviewed

大槻主税

熱処理 Vol. 43 ( 5 ) page： 317-323 2003.10

化学ベクトルセラミックス−骨伝導性を発現する表面構造のケミカルデザイン

大槻主税, 宮崎敏樹

バイオマテリアル-生体材料 Vol. 21 ( 5 ) page： 377-382 2003.9

生体活性なコンポジット材料

大槻主税

日本接着学会誌 Vol. 39 ( 3 ) page： 125-130 2003.3

無機材料分野におけるトピックス

大槻主税

バイオマテリアル-生体材料 Vol. 21 ( 1 ) page： 66-67 2003.1

Synthesis of Bioactive Organic-Inorganic Nanohybrid for Bone Repair through Sol-Gel Processing Reviewed

Toshiki Miyazaki, Chikara Ohtsuki and Masao Tanihara

J. Nanosci. Nanotech Vol. 3 page： 511-515 2003

Enhancement of Bone Growth in Titanium Fiber Mesh by Surface Modification with Hydrogen Peroxide Solution Containing Tantalum Chloride Reviewed

Taeseong Kim, Masahiko Suzuki, Chikara Ohtsuki, Kimihiko Masuda, Hiroshi Tamai, Eiichirou Watanabe, Akiyoshi Osaka and Hideshige Moriya

J. Biomed. Mater. Res. Part B: Appl. Biomater. Vol. 64B page： 19-26 2003

Deposition of bone-like apatite on silk fiber in a solution that mimics extracellular fluid Reviewed

Akari Takeuchi, Chikara Ohtsuki, Toshiki Miyazaki, Hiromi Tanaka, Masao Yamazaki and Masao Tanihara

J. Biomed. Mater. Res. Vol. 65A page： 283-289 2003

Apatite deposition on polyamide films containing carboxyl group in a biomimetic solution Reviewed

Toshiki MIYAZAKI, Chikara OHTSUKI, Yuji AKIOKA, Masao TANIHARA, Junko NAKAO, Yoshimitsu SAKAGUCHI and Shigeji KONAGAYA

J. Mater. Sci.: Materials in Medicine Vol. 14 page： 569-574 2003

Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope Reviewed

Atsuhiro Saito, Yoshihisa Suzuki, Shin-ichi Ogata, Chikara Ohtsuki and Masao Tanihara

Biochimi. Biophys. Acta Vol. 1651 page： 60-67 2003

Bioactive PMMA-Based Bone Cement Modified with Methacyloxypropyltrimetoxysilane and Calcium Salts . Effects of Calcium Salts on Apatite-Forming Ability - Reviewed

Akiko MORI, Chikara OHTSUKI, Atsushi SUGINO, Koichi URAMOTO, Toshiki MIYAZAKI, Masao TANIHARA and Akiyoshi OSAKA

J. Ceram. Soc. Japan Vol. 111 page： 738-742 2003

Detection of 1270 nm emission from singlet oxygen and photocytotoxic property of sugar-Pendant [60] fullerenes Reviewed

Yuji Mikata, Satowa Takagi, Maki Tanahashi, Sayoko Ishii, Makoto Obata, Yuichi Miyamoto, Kazuhito Wakita, Tsuyoshi Nishisaka, Toru Hirano, Toshiaki Ito, Mikio Hoshino, Chikara Ohtsuki, Masao Tanihara and Shigenobu Yano

Bioorganic & Medicinal Chemistry Letters Vol. 13 page： 3289-3292 2003

Bioactive PMMA bone cement prepared by modification withmethacryloxypropyltrimethoxysilane and calcium chloride Reviewed

Toshiki Miyazaki, Chikara Ohtsuki, Masayuki Kyomoto, Masao Tanihara, Akiko Mori and Kou-ichi Kuramoto

J. Biomed. Mater. Res Vol. 67A page： 1417-1423 2003

Comparative Study of Apatite Formation on Natural and Synthetic Polyamide in a Mimicking Solution to Body Fluid Reviewed

H. Inada, C. Ohtsuki, T. Miyazaki, S. Ogata and M. Tanihara

Bioceramics, ed. by Besim Ben-Nissan, Doron Sher and William Walsh, Trans Tech Publications Ltd ( 15 ) page： 15-18 2003

APATITE COATING ON AROMATIC POLYAMIDE FILMS VIA BIOMIMETIC MINERALIZATION

Yoshimitsu Sakaguchi, Sigeji Konagaya, Chikara Ohtsuki, Takahiro Kawai, Masao Tanihara and Toshiki Miyazaki

Proceedings of the 8th Japan International SAMPE Symposium, Vol. 2, ed. by N. Takeda, N. Hamada, S. Ogihara and A. Nakai, Society for the Advancement of Material and Process Engineering, 2003, pp. . page： 1081-1084 2003

APATITE FORMATION ON THE PMMA BONE CEMENT MODIFIED WITH ALKOXYSILANE AND CALCIUM SALT IN A SIMULATED BODY FLUID

Chikara Ohtsuki, Masao Tanihara, Toshiki Miyazaki, Atsushi Sugino Akiko Mori and Koichi Kurammoto

Ceramic Engineering & Science Prroceedings, Vol. 24, Issue 3, ed by Waltrauc M. Kriven and Hau-Tay Lin, The American Ceramic Society Vol. 24 ( 3 ) page： 233-238 2003

FABRICATION OF COMPOSITE FOR BONE REPAIRING FROM α-TRICALCIUM PHOSPHATE AND HYDROXYPROPYLCELLULOSE Reviewed

Toshiki Miyazaki, Chikara Ohtsuki, Haruna Iwasaki, Shin-ichi Ogata and Masao Tanihara

Ceramic Engineering & Science Prroceedings, Vol. 24, Issue 3, ed by Waltrauc M. Kriven and Hau-Tay Lin, The American Ceramic Society Vol. 24 ( 3 ) page： 215-220 2003

Addition of Zinc Oxide to Bioactive Glass-Ceramics

M. Kamitakahara, H. Inada, C. Ohtsuki, M. Tanihara and T. Miyazaki

Archives of BioCeramics Research Vol. 3, ed. by Masayuki Okazaki, Kunio Ishikawa, Kimihiro Yamashita, Yutaka Doi and Seiji Ban, Saga Printing Ltd ( 3 ) page： 360-363 2003

Preparation and Characterization of Novel PMMA-Based Bone Cement

S.B. Cho, S.B. Kim, K.J. Cho, C. Ohtsuki and M. Kamitakahara

Archives of BioCeramics Research Vol. 3, ed. by Masayuki Okazaki, Kunio Ishikawa, Kimihiro Yamashita, Yutaka Doi and Seiji Ban, Saga Printing Ltd ( 3 ) page： 342-345 2003

Development of Bioactive Molybdenum Metal by Alkali Treatment

Go Wakabayashi, Toshiki Miyazaki, Eiichi Ishida, Masahiro Ashizuka, Tadashi Kokubo and Chikara Ohtsuki

Archives of BioCeramics Research Vol. 3, ed. by Masayuki Okazaki, Kunio Ishikawa, Kimihiro Yamashita, Yutaka Doi and Seiji Ban, Saga Printing Ltd ( 3 ) page： 288-292 2003

Preparation of Three-dimensional Alginate-Apatite Nanohybrid

K. Hosoya, C. Ohtsuki, M. Kamitakahara, S. Ogata, T. Miyazaki and M. Tanihara

Archives of BioCeramics Research Vol. 3, ed. by Masayuki Okazaki, Kunio Ishikawa, Kimihiro Yamashita, Yutaka Doi and Seiji Ban, Saga Printing Ltd ( 3 ) page： 226-230 2003

Synthesis of Bioactive Organic-inorganic Hybrids from Starch by Modification with Alkoxysilane and Calcium Salt

Shouji Yasunaga, Toshiki Miyazaki, Eiichi Ishida, Masahiro Ashizuka, Chikara Ohtsuki and Masao Tanihara

Archives of BioCeramics Research Vol. 3, ed. by Masayuki Okazaki, Kunio Ishikawa, Kimihiro Yamashita, Yutaka Doi and Seiji Ban, Saga Printing Ltd ( 3 ) page： 218-221 2003

Experimental studies of the soft tissue response to bioactive PMMA-based bone cement modified with calcium salt and alkoxysilane

A. Sugino, C. Ohtsuki, T. Miyazaki, M. Tanihara, A. Mori and K. Kuramoto

Archives of BioCeramics Research Vol. 3, ed. by Masayuki Okazaki, Kunio Ishikawa, Kimihiro Yamashita, Yutaka Doi and Seiji Ban, Saga Printing Ltd ( 3 ) page： 138-142 2003

Effect of sericin coating on biodegradation of porous alpha-tricalcium phosphate

Akari Takeuchi, Chikara Ohtsuki, Masanobu Kamitakahara, Shin-ichi Ogata, Masao Tanihara, Toshiki Miyazaki, Masao Yamazaki, Yoshiaki Furutani and Hisao Kinoshita

Archives of BioCeramics Research Vol. 3, ed. by Masayuki Okazaki, Kunio Ishikawa, Kimihiro Yamashita, Yutaka Doi and Seiji Ban, Saga Printing Ltd ( 3 ) page： 114-117 2003

Development of Bioactive Organic-inorganic Hybrids with High Flexibility

Toshiki Miyazaki, Chikara Ohtsuki, Masahiro Ashizuka and Masao Tanihara

Archives of BioCeramics Research Vol. 3, ed. by Masayuki Okazaki, Kunio Ishikawa, Kimihiro Yamashita, Yutaka Doi and Seiji Ban, Saga Printing Ltd ( 3 ) page： 24-27 2003

Fabrication of porous ceramics consisting of biphasic tricalcium phosphate

Makoto Oishi, Chikara Ohtsuki, Masanobu Kamitakahara, Toshiki Miyazaki and Masao Tanihara

Archives of BioCeramics Research Vol. 3, ed. by Masayuki Okazaki, Kunio Ishikawa, Kimihiro Yamashita, Yutaka Doi and Seiji Ban, Saga Printing Ltd ( 3 ) page： 14-19 2003

Bioactive PMMA Bone Cement Prepared by Chemical Modification Reviewed

C. Ohtsuki, T. Miyazaki, A. Sugino, M. Tanihara, A. Mori and K. Kuramoto

Materials Science Forum ,Vols. 426-432, ed. by T. Chandra, J. M. Torralba and T. Sakai, Trans Tech Publication page： 3219-3224 2003

Organic Modification of Porous α-Tricalcium Phosphate to Improve Chemical Durability Reviewed

T. Miyazaki, C. Ohtsuki, H. Iwasaki, S. Ogata and M. Tanihara

Materials Science Forum ,Vols. 426-432, ed. by T. Chandra, J. M. Torralba and T. Sakai, Trans Tech Publications page： 3201-3206 2003

Inorganic-Organic Hybrids for Bone repairing Reviewed

Chikara OHTSUKI

Advances in Science and Technology 41, Materials in Clinical Applications VI, ed. by P. Vincenzini and R. Barbucci, Techna Srl page： 91-102 2003

Bone-bonding Behavior of PMMA Bone Cement Modified with Alkoxysilane and Calcium Acetate Reviewed

C. Ohtsuki, T. Miyazaki, A. Sugino, M. Tanihara, A. Mori and K. Kuramoto

Bioceramics, ed. by Besim Ben-Nissan, Doron Sher and William Walsh, Trans Tech Publications Ltd. ( 15 ) page： 361-364 2003

Control of Dissolution of Porous α-TCP by Coating with Hydroxypropylcellulose Reviewed

T. Miyazaki, C. Ohtsuki, H. Iwasaki, and M. Tanihara

Bioceramics, ed. by Besim Ben-Nissan, Doron Sher and William Walsh, Trans Tech Publications Ltd. ( 15 ) page： 63-66 2003

Apatite Formation on Silk Fiber in a Solution Mimicking Body Fluid Reviewed

A. Takeuchi, C. Ohtsuki, T. Miyazaki, S. Ogata, M. Tanihara, H. Tanaka, Y. Furutani and H. Kinoshita

Bioceramics, ed. by Besim Ben-Nissan, Doron Sher and William Walsh, Trans Tech Publications Ltd ( 15 ) page： 31-34 2003

Apatite Formation on Polyamide Films Containing Sulfonic Groups by Biomimetic Process Reviewed

T. Kawai, T. Miyazaki, C. Ohtsuki, M. Tanihara, J. Nakao, Y. Sakaguchi and S. Konagaya

Bioceramics, ed. by Besim Ben-Nissan, Doron Sher and William Walsh, Trans Tech Publications Ltd ( 15 ) page： 59-62 2003

人工臓器−この1年の進歩− 人工材料（無機）

大槻主税

人工臓器 Vol. 31 ( 3 ) page： 120-123 2002.12

2002年の化学　注目の論文：骨の再生を促すセラミックス

大槻主税

化学 Vol. 57 ( 1 ) page： 59-60 2002

Development of bioactive organic-inorganic hybrid for bone substitutes Reviewed

Chikara Ohtsuki, Toshiki Miyazaki and Masao Tanihara

Mater. Sci. Eng.: C Vol. 22 page： 27-34 2002

Apatite Deposition on Polyamide Films Containing Carboxyl Groups in Body Environment(jointly worked) Reviewed

T. Miyazaki, Y. Akioka, C. Ohtsuki, M. Tanihara, J. Nakao, Y. Sakaguchi and S. Konagaya

Bioceramics, Vol. 14, ed. by S. Brown, I. Clarke and P. Williams, Trans Tech Publications Ltd., Switzerland page： 133-136 2002

Apatite Formation on Silk Sericin in a Solution Mimicking Extracellular Fluid

A. Takeuchi, C. Ohtsuki, T. Miyazaki, S. Ogata, M. Tanihara, H. Tanaka, Y. Furutani and H. Kinoshita

Proceedings of 2nd Asian BioCereamics symposium (ABC2002), Committee of Asian BioCeramics symposium page： 93-96 2002

Bone formation induced by a synthetic oligopeptide derived from a bone morphogenetic protein-2

Shin-ichi Ogata, Atsuhiro Saito, Yoshiihisa Suzuki, Chikara Ohtsuki and Masao Tanihara

Proceedings of 2nd Asian BioCereamics symposium (ABC2002), Committee of Asian BioCeramics symposium page： 61-64 2002

Bioactivity of PMMA Bone Cement Modified with Alkoxysilane and Calcium salts

C. Ohtsuki, T. Miyazaki, M. Tanihara, A. Sugino, A. Mori and K. Kuramoto

Proceedings of 2nd Asian BioCereamics symposium (ABC2002), Committee of Asian BioCeramics symposium page： 43-46 2002

Apatite Formation on Polyamide Film Modified with Sulfonic Groups

T. Kawai, C. Ohtsuki, T. Miyazaki, M. Tanihara, J. Nakao, Y. Sakaguchi and S. Konagaya

Proceedings of 2nd Asian BioCereamics symposium (ABC2002), Committee of Asian BioCeramics symposium page： 29-32 2002

Coating of Organic-Inorganic Hybrids Containing Titanium Oxide on Organic Polymers

T. Miyazaki, K. Takahashi, C. Ohtsuki and M. Tanihara

Proceedings of 17th European Society for Biomaterials Conference page： 68 2002

Synthesis of Bioactive PMMA Bone Cement via Modification with Alkoxysilane and Calcium Acetate

T. Miyazaki, K. Takahashi, C. Ohtsuki and M. Tanihara

Proceedings of 17th European Society for Biomaterials Conference Vol. T163 page： 163 2002

Development of Organic-Inorganic Hybrid Materials Similar to Human Bone Tissue

J. M. Oliveira, T. Miyazaki, M. A. Lopes, C. Ohtsuki and J. D. Santos

Proceedings of 17th European Society for Biomaterials Conference Vol. T145 page： 145 2002

Coating of Bonelike Apatite on Polyamide Film via Chemical Modification with Calcium Salt(jointly worked) Reviewed

Y. Akioka, T. Miyazaki, C. Ohtsuki, M. Tanihara, J. Nakao, Y. Sakaguchi and S. Konagaya

Bioceramics, Vol. 14, ed. by S. Brown, I. Clarke and P. Williams, Trans Tech Publications Ltd., Switzerland page： 1478 2002

In vitro bioactivity and structure of alkali borosilicate glasses Reviewed

K. Tsuru, S. Hayakawa, C. Ohtsuki and A. Osaka

Phys. Chem. Glasses Vol. 43C page： 326-329 2002

Mechanism of bonelike apatite formation on bioactive tantalum metal in a simulated body fluid Reviewed

Toshiki Miyazaki, Hyun-Min Kim, Tadashi Kokubo, Chikara Ohtsuki, Hirofumi Kato and Takashi Nakamura

Biomaterials Vol. 23 page： 827-832 2002

Enhancement of bonding strength by graded structure at interface between apatite layer and bioactive tantalum metal Reviewed

T. Miyazaki, H.-M. Kim, T. Kokubo, C. Ohtsuki, K. Kato and T. Nakamura

J. Mater. Sci.: Materials in Medicine Vol. 13 page： 651-655 2002

Improvement of Chemical Durability of Porous alpha-TCP by Coating with Organic Polymer

T. Miyazaki, C. Ohtsuki, H. Iwasaki and M. Tanihara

Proceedings of 2nd Asian BioCereamics symposium (ABC2002), Committee of Asian BioCeramics symposium page： 129-132 2002

Apatite Deposition on Organic-inorganic Hybrids Prepared from Hydroxyethylmethacrylate by Modification with Alkoxysilane and Calcium Salt in Body Environment Reviewed

T. Miyazaki, C. Ohtsuki and M. Tanihara

Ceramic Engineering & Science Proceedings, ed. by H.-T. Lin and M. Singh, American Ceramic Society Vol. 23 ( 4 ) page： 797-804 2002

セラミックスによる新しい人工骨

大槻主税

THE BONE Vol. 15 ( 5 ) page： 431-433 2001.9

Synthesis of Bioactive Organic-Inorganic Hybrid from Methacryloxyproplytrimethoxysilane and 2-Hydroxyethylmethacrylate Reviewed

C. Ohtsuki, T. Miyazaki and M. Tanihara

Bioceramics, Vol. 13, Trans Tech Publications Ltd., Switzerland Vol. 13 page： 39-42 2001

Synthesis and In Vitro Behavior of Organically Modified Silicate Containing Ca Ions Reviewed

Kanji Tsuru, Yasushi Aburatani, Takeshi Yabuta, Satoshi Hayakawa, Chikara Ohtsuki and Akiyoshi Osaka

J. Sol-Gel Sci. Tech. ( 21 ) page： 89-96 2001

Spontaneous Apatite Deposition on PMMA Bone Cement Modified with Alkoxysilane and Calcium Salt in Simulated Body Fluid

Toshiki Miyazaki, Masayuki Kyomoto, Chikara Ohtsuki, Masao Tanihara and Akiyoshi Osaka

Materials Science for the 21st Century The Society of Materials Science Vol. B page： 79-82 2001

Bonelike Apatite Formation on Niobium Oxide Gel in a Simulated Body Fluid Reviewed

T. Miyazaki, H.-M. Kim, T. Kokubo, H. Kato, T. Nakamura and C. Ohtsuki

Bioceramics, Vol. 13, Trans Tech Publications Ltd., Switzerland Vol. 13 page： 43-46 2001

Development of Bioactive PMMA-based Cement by Modification with Alkoxysilane and Calcium Salt Reviewed

C. Ohtsuki, T. Miyazaki, M. Kyomoto, M. Tanihara and A. Osaka

J. Mater. Sci.: Materials in Medicine Vol. 12 page： 895-899 2001

Kinetics of Apatite Deposition of Silica Gel Dependent on the Inorganic Ion Composition of Simulated Body Fluids Reviewed

Kanji Tsuru, Masaaki Kubo, Satoshi Hayakawa, Chikara Ohtsuki and Akiyoshi Osaka

J. Ceram. Soc. Japan Vol. 109 page： 412-418 2001

Synthesis and In Vitro Behavior of Organically Modified Silicate Containing Ca Ions Reviewed

Kanji Tsuru, Yasushi Aburatani, Takeshi Yabuta, Satoshi Hayakawa, Chikara Ohtsuki and Akiyoshi Osaka

J. Sol-Gel Sci. Tech. Vol. 21 page： 89-96 2001

Apatite-Forming Ability of Niobium Oxide Gels in a Simulated Body Fluid Reviewed

Toshiki Miyazaki, Hyun-Min Kim, Tadashi Kokubo, Chikara Ohtsuki and Takashi Nakamura

J. Ceram. Soc. Japan Vol. 109 page： 929-933 2001

In vivo Evaluation of Bone-bonding of Titanium Metal Chemically Treated with a Hydrogen Peroxide Solution Containing Tantalum Chloride Reviewed

S. Kaneko, K. Tsuru, S. Hayakawa, S. Takemoto, C. Ohtsuki, T. Ozaki, H. Ionue and A. Osaka

Biomaterials Vol. 22 page： 875-881 2001

Push-out testing and histological evaluation of glass reinforced hydroxyapatite composites implanted in the tibia of rabbits Reviewed

M. A. Lopes, J. D. Santos, F. J. Monteiro, C. Ohtsuki, A. Osaka, S. Kaneko and H. Inoue

J. Biomed. Mater. Res. Vol. 54 page： 463-469 2001

6WBCレビュー　セラミックバイオマテリアル

大槻主税, 金　鉉敏

生体材料 Vol. 18 ( 6 ) page： 263-265 2000.12

90年代のセラミックス，生体関連材料分野の発展

大槻主税

セラミックス Vol. 35 page： 1046-1051 2000.12

Synthesis of Bioactive Organic-Inorganic Hybrid with g-Methacryloxypropyl trimethoxysilane Reviewed

Takeshi Yabuta, Kanji Tsuru, Satoshi Hayakawa, Chikara Ohtsuki and Akiyoshi Osaka

J. Sol-Gel Sci. Tech. Vol. 19 page： 745-748 2000

Surface Modification of Polymers with Grafting and Coating of Silane Hybrids and Their Bioactivity Reviewed

Masaaki Kubo, Seisuke Takashima, Kanji Tsuru, Satoshi Hayakawa, Chikara Ohtsuki and Akiyoshi Osaka

Mater. Res. Soc. Symp. Proc. Vol. 576 page： 377-382 1999

Synthesisi of Bioactive Organic-Inorganic Hybrid Reinforced with Aerosil^(R) Reviewed

Yasushi Aburatani, Satoshi Hayakawa, Chikara Ohtsuki and Akiyoshi Osaka

Bioceramics, Vol.12, ed. by H. Ohgushi, G. W. Hastings and T. Yoshikawa, World Scientific Publishing Co. Pte. Ltd., Singapore page： 457-460 1999

Osteocompatibility and in vivo Evaluation of Glass Reinforced Hydorxyapatite Composite Reviewed

M. A. Lopes, J. D. Santos, F. J. Monteiro, C. Ohtsuki, A. Osaka, S. Kaneko and H. Ionue

Bioceramics, Vol.12, ed. by H. Ohgushi, G. W. Hastings and T. Yoshikawa, World Scientific Publishing Co. Pte. Ltd., Singapore page： 421-424 1999

Bone Bonding Ability of Ti-6Al-4V Alloy with a Hydrogen Peroxide Solution Reviewed

Shinya Kaneko, Shinji Takemoto, Chikara Ohtsuki, Toshifumi Ozaki, Hajime Inoue and Akiyoshi Osaka

Bioceramics, Vol.12, ed. by H. Ohgushi, G. W. Hastings and T. Yoshikawa, World Scientific Publishing Co. Pte. Ltd., Singapore page： 295-298 1999

Mechanism of Apatite Formation on a Sodium Silicate Glass in a Simulated Body Fluid Reviewed

Satoshi Hayakawa, Kanji Tsuru, Chikara Ohtsuki and Akiyoshi Osaka

J. Am. Ceram. Soc. Vol. 82 page： 2155-2160 1999

Cytocompatibility of Titanium Metal Treated with Hydrogenperoxide Containing Tantalum Chloride(jointly worked) Reviewed

Chikara Ohtsuki, Keizo Kobayashi, Satoshi Hayakawa, Akiyoshi Osaka and Hajime Inoue

Bioceramics, Vol. 11, ed. by R. Z. LeGeros and J. P. LeGeros, World Scientific Publishing Co. Pte. Ltd. , Singapore, page： 679-682 1998

Apatite Formation on the Surface of Silicone Elastomer Covered with Bioactive Glass Particles Reviewed

Journal of Materials Science Japan Vol. 47 ( 6 ) page： 565-570 1998

Molecular Dynamic Simulation of Microsegregation of Alkaline Earth Fluoride in Amorphous Alkaline Earth Silicate System Reviewed

A. Osaka, S. Hayakawa and C. Ohtsuki

Proceedings of XVIII International Congress on Glass, ed. By Manoj K. Choudhary, Norman T. Hrff and Charles H. Drummond III, The American Ceramic Society, San francisco, CA, USA page： 55-60 1998

²⁹Si and ³¹P MAS-NMR Analysis of Apatite Formation on Sodium Silicate Glass in A Simulated Body Fluid Reviewed

S. Hayakawa. K. Tsuru, C. Ohtsuki and A. Osaka

Proceedings of XVIII International Congress on Glass, ed. By Manoj K. Choudhary, Norman T. Huff and Charles H. Drummond III, The American Ceramic Society, San francisco, CA, USA page： 36-41 1998

Synthesis of Blood Compatible Ceramic Powders and a Convenient Method of Evaluating an Anti-clotting Property Reviewed

Seisuke Takashima, Chikara Ohtsuki, Satoshi Hayakawa and Akiyoshi Osaka

Bioceramics, Vol. 11, ed. by R. Z. LeGeros and J. P. LeGeros, World Scienific Publishing Co. Pte. Ltd. , Singapore, page： 695-698 1998

Ultrasonic implantation of calcium metasilicate glass particles into PMMA Reviewed

K. Tsuru, S. Hayakawa, C. Ohtsuki and A. Osaka

J. Mater. Sci.: Materials in Medicine Vol. 9 page： 479-484 1998

Molecular dynamic simulation of heterogeneity and chemical states of fluorine in amorphous alkaline earth silicate systems Reviewed

Satoshi Hayakawa, Chikara Ohtsuki, Syuji Matsumoto, Akiyoshi Osaka and Yoshinari Miura

Computational Mater. Sci. Vol. 9 page： 337-342 1998

An x-ray photoelectron spectroscopic study of the chemical states of fluorine atoms in calcium silicate glasses Reviewed

Satoshi Hayakawa, Akira Nakao, Chikara Ohtsuki, Akiyoshi Osaka, Syuji Matsumoto and Yoshinari Miura

J. Mater. Res. Vol. 13 page： 739-743 1998

Biomimetic coating of bone-like apatite on glass beads Reviewed

Akiyoshi Osaka, Shinji Takemoto, Satoshi Hayakawa and Chikara Ohtsuki

Materials Science Research International Vol. 4 page： 60-63 1998

Bioactive Gel Coatings Derived from Vinyltrimethoxysilane Reviewed

Kanji Tsuru, Satoshi Hayakawa, Chikara Ohtsuki and kiyoshi Osaka

J. Sol-Gel Sci. Tech Vol. 13 page： 237-240 1998

生体活性ガラスを複合化したシリコーンゴム表面におけるアパタイト形成 Reviewed

都留寛治, 早川聡, 大槻主税, 尾坂明義

材料 Vol. 47 page： 565-570 1998

Bioactivity and Structure of Organically Modified Silicates Synthesized by the Sol-Gel Method Reviewed

Kanji Tsuru, Satoshi Hayakawa, Chikara Ohtsuki and Akiyoshi Osaka

Bioceramics, Vol. 11, ed. by R. Z. LeGeros and J. P. LeGeros, World Scientific Publishing Co. Pte. Ltd. , Singapore, page： 423-426 1998

Effects of Cations on Surface Reactions and Apatite Nucleation on Silicate Glasses in a Body Environment Reviewed

Akiyoshi Osaka, Satoshi Hayakawa and Chikara Ohtsuki

Bioceramics, Vol. 11, ed. by R. Z. LeGeros and J. P. LeGeros, World Scientific Publishing Co. Pte. Ltd. Singapore, page： 489-492 1998

Bioactivity of Nb(V)and Ta(V)-Doped Caclium Silicate Glasses(jointly worked)

Naoki Imayoshi, Satoshi Hayakawa, Chikara Ohtsuki and Akiyoshi Osaka

Memoirs of Fac. Eng. Okayama Univ Vol. 31 ( 2 ) page： 39-44 1997

Bioactivity of titanium treated with hydrogen peroxide solutions containing metal chlorides Reviewed

Chikara Ohtsuki, Hirohisa Iida, Satoshi Hayakawa and Akiyoshi Osaka

J. Biomed. Mater. Res. Vol. 35 page： 39-47 1997

Bioactivity of Alkali and Alkaline Earth Borosilicate Glasses

Akiyoshi Osaka, Satoshi Hayakawa, Kanji Tsuru and Chikara Ohtsuki

Borate Glasses, Crystals & Melts, ed. by A. C. Wright, S. A. , Feller and A. C. Hannon, The Society of Glass Technology, Sheffield, page： 490-497 1997

Coagulation times of blood in contact with gel derived silica alumina composite powders Reviewed

Seisuke Takashima, Chikara Ohtsuki, Satoshi Hayakawa and Akiyoshi Osaka

Bioceramics, Vol. 10, ed L. Sedel and C. Rey, Elsevier Science Ltd. , Oxford page： 527-530 1997

Effects of multivalent cations in calcium silicate glasses on bioactivity Reviewed

Naoki Imayoshi, Chikara Ohtsuki, Satoshi Hayakawa and Akiyoshi Osaka

Bioceramics, Vol. 10, ed. by L. Sedel and C. Rey, Elsevier Science Ltd. , Oxford page： 41-44 1997

Bioactivity and Structure of Organically Modified Silicates Synthesized by the Sol-Gel Method Reviewed

Kanji Tsuru, Satoshi Hayakawa, Chikara Ohtsuki and Akiyoshi Osaka

Bioceramics, Vol. 10, ed. by L. Sedel and C. Rey, Elsevier Science Ltd. , Oxford page： 33-36 1997

Effect of fluoride substitution on the biocompatibility of hydroxyapatite Reviewed

K. A. Hing, L. Di-Silvio, I. R. Gibson, C. Ohtsuki, L. J. Jha, S. M. Best and W. Bonfield

Bioceramics, Vol. 10, ed. by L. Sedel and C. Rey, Elsevier Science Ltd. , Oxford page： 19-22 1997

Bioactive Calcium Borosilicate Glasses for Enameling Titanium

Akiyoshi Osaka, Keizo Kobayashi, Satoshi Hayakawa and Chikara Ohtsuki

Memoirs of Fac. Eng. Okayama Univ. Vol. 31 ( 2 ) page： 45-51 1997

Evaluation of in vitro bioactivity and biocompatibility of Bioglass-reinforced polyethylene composite Reviewed

J. Huang, L. Di Silvio, M. Wang, I. Rehman, C. Ohtsuki and W. Bonfield

Vol. 8 page： 809-813 1997

Bioacivity of sol-gel derived organically modified silicates, Part I: In vitro examination Reviewed

K. TSURU, C. OHTSUKI, A. OSAKA, T. IWAMOTO and J. D. MACKENZIE

J. Mater. Sci.: Materials in Medicine Vol. 8 page： 157-161 1997

Spray Pyrolysis Preparation of Apatite-Composite Particles for Biological Application Reviewed

Akiyoshi Osaka, Kanji Tsuru, Hirohisa Iida, Chikara Ohtsuki and Satoshi Hayakawa

J. Sol-Gel Sci. Tech. Vol. 8 page： 655-661 1997

Synthesis of Bioactive Ormosils by the Sol-Gel Method Reviewed

K. Tsuru, C. Ohtsuki, A. Osaka, T. Iwamoto and J. D. Mackenzie

Mat. Res. Soc. Symp. Proc. Vol. 435 page： 403-408 1996

MAS NMR studies of apatite formation on 50CaO^.50SiO₂ glass in a simulated body fluid Reviewed

S. Hayakawa, K. Tsuru, H. Iida, C. Ohtsuki and A. Osaka

Phys. Chem. Glass Vol. 37 page： 188-192 1996

Apatite Formation on Silica Gel in Simulated Body Fluid: Its Dependence on Structures of Silica Gels Prepared in Different Media Reviewed

Sung-Baek Cho, Kazuki Nakanishi, Tadashi Kokubo, Naohiro Soga, Chikara Ohtsuki and Takashi Nakamura

J. Biomed. Mater. Res. (Applied Biomaterials) Vol. 33 page： 145-151 1996

³¹P MAS-NMR Studies of Phosphate Salts Formation on Calcium-containing Oxide Glasses in a Simulated Body Fluid³¹³¹ Reviewed

Satoshi Hayakawa, Kanji Tsuru, Hirohisa Iida, Chikara Ohtsuki and Akiyoshi Osaka

J. Ceram. Soc. Japan Vol. 104 ( 11 ) page： 1000-1003 1996

MAS NMR Study on Bioactivity of Sol-Gel Derived Organically Modified Silicates Reviewed

K. Tsuru, S. Hayakawa, C. Ohtsuki and A. Osaka

Bioceramics, Vol. 9, ed. by T. Kokubo, T. Nakamura and F. Miyaji, Elsevier Science Ltd. , Oxford page： 419-422 1996

Surface Treatement and Bioactivity of Silicone Elastomer Reviewed

C. Ohtsuki, S. Suzuki, K. Tsuru, S. Hayakawa and A. Osaka

Bioceramics, Vol. 9, ed. by T. Kokubo, T. Nakamura and F. Miyaji, Elsevier Science Ltd. , Oxford page： 379-382 1996

Effects of Fluoride Ions on Apatite Formation Ability of Calcium Silicate Glasses Reviewed

A. Nakao, K. Tsuru, S. Hayakawa, C. Ohtsuki and A. Osaka

Bioceramics, Vol. 9, ed. by T. Kokubo, T. Nakamura and F. Miyaji, Elsevier Science Ltd. , Oxford page： 131-134 1996

Dependence of Apatite Formation on Silica Gel on Its Structure: Effect of Heat Treatment Reviewed

Sung-Baek Cho, Kazuki Nakanishi, Tadashi Kokubo, Naohiro Soga, Chikara Ohtsuki, Takashi Nakamura, Toshiaki Kitsugi and Takao Yamamuro

J. Am. Ceram. Soc. Vol. 78 ( 7 ) page： 1769-1774 1995

CaO-B₂O₃-SiO₂系ガラスの生体活性の組成依存性：in vitro 評価 Reviewed

大槻主税, 小林幸生, 都留寛治, 尾坂明義

材料 Vol. 44 ( 501 ) page： 693-699 1995

Bioactivity of Na₂O-CaO-SiO₂ Glasses Reviewed

Hyun-Min Kim, Fumiaki Miyaji, Tadashi Kokubo, Chikara Ohtsuki, Takashi Nakamura and Takao Yamamuro

J. Am. Ceram. Soc. Vol. 78 ( 9 ) page： 2405-2411 1995

Effect of Alcohol on Bioactivity of Glasses

K. Tsuru, C. Nishiyama, C. Ohtsuki and A. Osaka

Memoirs of the Faculty of Engineering Okayama University Vol. 29 ( 2 ) page： 83-88 1995

Effect of MgO and BaO on Bioactivity of CaO-SiO₂ Glasses Reviewed

K. Tsuru, C. Ohtsuki and A. Osaka

Proceedings of XVII International Congress on Glass, Vol.5, ed. by G.Fangtion, Chinese Ceramic Society, Beijing page： 85-90 1995

Transmission electron microscopic observation of glass-ceramic A-W and apatite layer formed on its surface in a simulated body fluid Reviewed

Chikara Ohtsuki, Yukio Aoki, Tadashi Kokubo, Yoshio Bando, Masashi Neo and Takashi Nakamura

J. Ceram. Soc. Japan Vol. 103 ( 5 ) page： 449-454 1995

チタン金属への生体活性の付与 Reviewed

張　栩, 宮路史明, 八尾　健, 小久保正, 大槻主税

粉体および粉末冶金 Vol. 41 ( 6 ) page： 664-667 1994

The role of hydrated silica, titania and alumina in inducing apatite on implants Reviewed

P. Li, C. Ohtsuki, T. Kokubo, K. Nakanishi, N. Soga and K. deGroot

J. Biomed. Mater. Res. Vol. 28 ( 1 ) page： 7-15 1994

Ultrastructural study of the A-W GC-bone interface after long-term implantation in rat and human bone Reviewed

M. Neo, T. Nakamura, C. Ohtsuki, R. Kasai, T. Kokubo and T. Yamamuro

J. Biomed. Mater. Res. Vol. 28 ( 3 ) page： 365-372 1994

Effects of Al₂O₃ and TiO₂ on Bioactivity of CaO-SiO₂ Glasses Reviewed

C. Ohtsuki, A. Osaka and T. Kokubo

Bioceramics, Vol. 7, ed by O. H. Andersson and A. Yli-Urpo, Butlerworth-Heinemenn Ltd. , Oxford page： 73-78 1994

Bioactive Glass-Ceramic Containing Crystalline Apatite and Wollastonite Initiates Biomineralization in Bone Cell Cultures Reviewed

J. M. Sautier, T. Kokubo, T. Ohtsuki, J. R. Nefussi, H. Boulekbache, M. Oboeuf, S. Loty, C. Loty and N. Forest

Calcif. Tissue Int. Vol. 55 page： 458-466 1994

Chemical Treatment of Ti Metal For Inducing its Bioactivity Reviewed

F. Miyaji, Xu Zhang, T. Yao, T. Kokubo, C. Ohtsuki, T. Kitsugi, T. Yamamuro and T. Nakamura

Bioceramics, Vol. 7, ed. by O.H.Andersson and A.Yli-Urpo, Butterworth-Heinemann Ltd, Oxford page： 119-124 1994

Dependence of Bone-like Apatite Formation on Structure of Silica Gel Reviewed

T. Kokubo, S. B. Cho, K. Nakanishi, N. Soga, C. Ohtsuki, T. Kitsugi, T. Yamamuro and T. Nakamura

Bioceramics, Vol. 7, ed. by O.H.Andersson and A.Yli-Urpo, Butterworth-Heinemann Ltd, Oxford page： 49-54 1994

Effect of Ions in Aqueous Media on Hydroxyapatite Induction by Silica Gel and its Relevance to Bioactivity of Bioactive Glasses and Glass-ceramics Reviewed

P. Li, C. Ohtsuki, T. Kokubo, K. Nakanishi, N. Soga, T. Nakamura and T. Yamamuro

J. Applied Biomaterials Vol. 4 page： 221-229 1993

Effects of ions dissolved from bioactive glass-ceramic on surface apatite formation Reviewed

T. Kokubo, H. Kushitani, C. Ohtsuki, S. Sakka and T. Yamamuro

J. Mater. Sci.: Materials in Medicine Vol. 4 page： 1-4 1993

Processes of formation of bone-like apatite layer on silica gel Reviewed

P. Li, C. Ohtsuki, T. Kokubo, K. Nakanishi, N. Soga, T. Nakamura and T. Yamamuro

J. Mater. Sci.: Materials in Medicine Vol. 4 page： 127-131 1993

Apatite formation on three kinds of bioactive material at an early stage in vivo: A comparative study by transmission electron microscopy Reviewed

M. Neo, T. Nakamura, C. Ohtsuki, T. Kokubo and T. Yamamuro

J. Biomed. Mater. Res. Vol. 27 page： 999-1006 1993

Mechanism of apatite formation on CaO-SiO₂-P₂O₅ glasses in a simulated body fluid Reviewed

Chikara Ohtsuki, Tadashi Kokubo and Takao Yamamuro

Journal of Non-Crystalline Solids Vol. 143 page： 84-92 1992.5

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

It has been shown for various types of glasses and glass-ceramics that the essential condition for them to bond to living bone is the formation of an apatite layer on their surfaces in the body. CaO,SiO2-based glasses formed the surface apatite layer in a simulated body fluid, whereas CaO,P2O5-based glasses did not form it. This means that the rate of the apatite nucleation on the surfaces of the former glasses is much higher than that of the latter glasses. The increase in the degree of the supersaturation of the surrounding fluid with respect to the apatite due to dissolution of the calcium ion from the CaO,SiO2-based glasses was almost equal to that due to dissolution of the phosphate ion from the CaO,P2O5-based glasses. The high rate of the apatite nucleation on the surface of the former glasses is therefore attributed to the lower interface energy between the apatite and the glass surfaces. The CaO,SiO2-based glasses form a silica hydrogel on their surfaces prior to formation of the apatite layer. This means that the hydrated silica provides specific favorable sites for the apatite nucleation.

DOI： 10.1016/S0022-3093(05)80556-3

Compositional dependence of bioactivity of glasses in the system CaO-SiO₂-Al₂O₃: Its in vitro evaluation Reviewed

C. Ohtsuki, T. Kokubo and T. Yamamuro

J. Mater. Sci.: Materials in Medicine Vol. 3 page： 119-125 1992.3

A comparative study of ultrastructures of the interfaces between four kinds of surface-active ceramic and bone Reviewed

M. Neo, S. Kotani, T. Nakamura, T. Yamamuro, C. Ohtsuki, T. Kokubo and Y. Bando

J. Biomed. Mater. Res. Vol. 26 page： 1419-1432 1992

Differences in ceramic-bone interface between surface-active ceramics and resorbable ceramics: A study by scanning and transmission electron microscopy Reviewed

M. Neo, S. Kotani, Y. Fujita, T. Nakamura, T. Yamamuro, Y. Bando, C. Ohtsuki and T. Kokubo

J. Biomed. Mater. Res. Vol. 26 page： 255-267 1992

Chemical reaction of bioactive glass and glass-ceramics with a simulated body fluid Reviewed

T. Kokubo, H. Kushitani, C. Ohtsuki, S. Sakka and T. Yamamuro

J. Mater. Sci.: Materials in Medicine Vol. 3 page： 79-83 1992

Apatite Formation Induced by Silica Gel in a Simulated Body Fluid Reviewed

P. Li, C. Ohtsuki, T. Kokubo, K. Nakanishi, N. Soga, T. Nakamura and T. Yamamuro

J. Am. Ceram. Soc. Vol. 75 page： 2094-2097 1992

Mechanism and strength of bonding between two bioactive ceramics in vivo Reviewed

Y. Fujita, T. Yamamuro, T. Nakamura, T. Kitsugi, S. Kotani, C. Ohtsuki and T. Kokubo

J. Biomed. Mater. Res. Vol. 26 page： 1311-1324 1992

Compositional Dependence of Bioactivity of Glasses in the System CaO-SiO₂-P₂O₅: Its in Vitro Evaluation Reviewed

C. Ohtsuki, T. Kokubo, K. Takatsuka and T. Yamamuro

J. Ceram. Soc. Japan (Seramikkusu Ronbunshi) Vol. 99 page： 1-6 1991.1

Apatite formation on the surface of Ceravital-type glass-ceramic in the body Reviewed

C. Ohtsuki, H. Kushitani, T. Kokubo, S. Kotani and T. Yamamuro

J. Biomed. Mater. Res. Vol. 25 page： 1363-1370 1991

The bonding behavior of calcite to bone Reviewed

Y. Fujita, T. Yamamuro, T. Nakamura, S. Kotani, C. Ohtsuki and T. Kokubo

J. Biomed. Mater. Res. Vol. 25 page： 991-1003 1991

Bone bonding mechanism of β-tricalcium phosphate Reviewed

S. Kotani, Y. Fujita, T. Kitsugi, T. Nakamura, T. Yamamuro, C. Ohtsuki and T. Kokubo

J. Biomed. Mater. Res. Vol. 25 page： 1303-1315 1991

Difference in Bone Bonding Mechanisms between Surface Active Ceramics & Resorbable Ceramics : Scanning and Transmission Electron Microscopic Study Reviewed

M. Neo, S. Kotani, Y. Fujita, T. Nakamura, T. Yamamuro, Y. Bando, M. Yokoyama, C. Ohtsuki and T. Kokubo

Bioceramics, Vol.4, ed. by W. Bonfiedld, G. W. Hastings and K. E. Tanner, Butterworth-Heinemann, Guilford page： 165-170 1991

Surface Structure of Bioactive Glass-Ceramic A-W Implanted into Sheep and Human Vertebra Reviewed

T. Kokubo, C. Ohtsuki, S. Kotani, T. Kitsugi and T. Yamamuro

Bioceramics, Vol. 2, ed. by G.Heimke, German Ceramic Society, Cologne page： 113-120 1990.9

Bioactivity of Glass-Ceramics Reviewed

T. Kokubo, H. Kushitani, C. Ohtsuki, Y. Ebisawa, T. Kitsugi, K. Oura, S. Kotani and T. Yamamuro

Proceedings of XV International Congress on Glass, Vol.3a, ed. by O. V. Mazurin, Nauka, Leningrad page： 114-119 1989.7

ZrS₂のホットプレス焼結と熱的変化 Reviewed

田中嘉一郎, 三木章伍, 大槻主税, 植月徹, 木島弌倫

材料 Vol. 38 page： 1-7 1989

TiSe_1.6及びTiSe_1.5のホットプレス焼結と熱的変化 Reviewed

田中嘉一郎, 大槻主税, 植月徹, 中沢泰朗

窯業協会誌 Vol. 96 page： 165-170 1988.2

TiSe₂の合成及びその焼結 Reviewed

田中嘉一郎, 大槻主税, 土居俊雄, 植月徹, 中沢泰朗

窯業協会誌 Vol. 95 page： 623-629 1987.6

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