研究者詳細 - 豊國　伸哉

論文 - 豊國　伸哉

分割表示 1,173 件中 121 - 140 件目／全件表示 >>

Mth1 deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice 査読有り国際誌

Funahashi S.

Free Radical Research 54 巻 ( 2-3 ) 頁： 195 - 205 2020年3月

アスベストは卵巣表層上皮に鉄過剰状態を形成し卵巣がんの発がんに関わる

本岡大社, 伊藤文哉, 豊國伸哉

日本病理学会会誌 109 巻 ( 1 ) 頁： 314 - 314 2020年3月

Plasma-activated medium promotes autophagic cell death along with alteration of the mTOR pathway 国際誌

Yoshikawa Nobuhisa, Liu Wenting, Nakamura Kae, Yoshida Kosuke, Ikeda Yoshiki, Tanaka Hiromasa, Mizuno Masaaki, Toyokuni Shinya, Hori Masaru, Kikkawa Fumitaka, Kajiyama Hiroaki

SCIENTIFIC REPORTS 10 巻 ( 1 ) 2020年1月

Augmented oxidative stress increases 8-oxoguanine preferentially in the transcriptionally active genomic regions 査読有り国際誌

Akatsuka S.

Free Radical Research 2020年

Oxidative stress-dependent and -independent death of glioblastoma cells induced by non-thermal plasma-exposed solutions 査読有り国際誌

Tanaka Hiromasa, Mizuno Masaaki, Katsumata Yuko, Ishikawa Kenji, Kondo Hiroki, Hashizume Hiroshi, Okazaki Yasumasa, Toyokuni Shinya, Nakamura Kae, Yoshikawa Nobuhisa, Kajiyama Hiroaki, Kikkawa Fumitaka, Hori Masaru

SCIENTIFIC REPORTS 9 巻 ( 1 ) 頁： 13657 2019年9月

How iron is handled in the course of heme catabolism: Integration of heme oxygenase with intracellular iron transport mechanisms mediated by poly (rC)-binding protein-2 国際誌

Yanatori I.

Archives of Biochemistry and Biophysics 672 巻頁： 108071 2019年9月

Carbonic anhydrase 9 confers resistance to ferroptosis/apoptosis in malignant mesothelioma under hypoxia 査読有り国際誌

Li Z.

Redox Biology 26 巻頁： 101297 - 101297 2019年9月

アスベストは鉄過剰環境を形成し卵巣癌の発癌に関わる(Asbestos contributes to ovarian carcinogenesis via iron overload)

本岡大社, 伊藤文哉, 田代浩徳, 片渕秀隆, 豊國伸哉

日本癌学会総会記事 78回巻頁： E - 1077 2019年9月

L-Dehydroascorbic acid recycled by thiols efficiently scavenges non-thermal plasma-induced hydroxyl radicals 査読有り国際誌

Okazaki Yasumasa, Tanaka Hiromasa, Hori Masaru, Toyokuni Shinya

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 669 巻頁： 87 - 95 2019年7月

アスベストの曝露は上皮性悪性卵巣腫瘍の発癌に関与する

水野勇太, 本岡大社, 豊國伸哉

日本病理学会会誌 108 巻 ( 1 ) 頁： 460 - 461 2019年4月

A scrutiny of circulating microRNA biomarkers for drug-induced tubular and glomerular injury in rats.

Toxicology 415 巻頁： 26-36 2019年3月

Non-thermal plasma-activated medium modified metabolomic profiles in the glycolysis of U251SP glioblastoma 国際誌

Kurake Naoyuki, Ishikawa Kenji, Tanaka Hiromasa, Hashizume Hiroshi, Nakamura Kae, Kajiyama Hiroaki, Toyokuni Shinya, Kikkawa Fumitaka, Mizuno Masaaki, Hori Masaru

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 662 巻頁： 83 - 92 2019年2月

Twist1 was detected in mesenchymal cells of mammary fibroadenoma and invasive components of breast carcinoma in rats.

Funahashi S, Okazaki Y, Nagai H, Chew SH, Ogawa K, Toyoda T, Cho YM, Toyokuni S

Journal of toxicologic pathology 32 巻 ( 1 ) 頁： 19-26 2019年1月

Nonthermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)dependent manner 査読有り国際誌

Sato K.

Journal of Clinical Biochemistry and Nutrition 65 巻 ( 4 ) 頁： 8 - 15 2019年

Iron Metabolism and Ferroptosis 査読有り国際誌

Toyokuni Shinya, Yanatori Izumi

FERROPTOSIS IN HEALTH AND DISEASE 頁： 27 - 41 2019年

尿細管障害と糸球体障害に対する新規バイオマーカーとしての血中microRNAの検討

香川匠, Tomáš ZÁRYBNICKÝ, 大見貴尚, 白井勇司, 豊國伸哉, 織田進吾, 横井毅

日本毒性学会学術年会 46 巻 ( 0 ) 頁： P - 233 2019年

掲載種別：研究論文（学術雑誌）出版者・発行元：日本毒性学会

[Introduction] Drug-induced acute kidney injury (AKI) is a frequent cause of adverse drug reaction. Serum creatinine (CRE) and blood urea nitrogen (BUN) are widely used as standard biomarkers for kidney injury; however, the sensitivity and specificity are considered to be low. In recent years, circulating microRNA (miRNAs) have been attracting considerable attention as novel biomarkers for organ injury, but there are currently no established miRNA biomarkers for drug-induced AKI. The present study aimed to identify plasma miRNAs that may enable early and specific detection of drug-induced tubular and glomerular injury through next-generation sequencing analysis. [Methods] Six-week old male Sprague-Dawley rats were administered cisplatin and gentamicin to induce tubular injury. To create glomerular injury models, puromycin and doxorubicin were administered, and these models were always accompanied by tubular damage. Small RNA-sequencing was performed to analyze time-dependent changes in the plasma miRNA profiles. [Results and Discussion] In the differential analysis, miR-3473 was specifically up-regulated in the glomerular injury models. miR-143-3p and miR-122-5p were commonly down-regulated in all models, and the changes were earlier than the traditional biomarkers, such as plasma CRE and BUN. These data indicated that changes in the specific miRNAs in plasma may enable the early and sensitive detection of tubular and glomerular injuries. The present study suggests the potential utility of plasma miRNAs in the early and type-specific detection of drug-induced AKI.

DOI： 10.14869/toxpt.46.1.0_P-233

Chemiluminescence imaging of UVA induced reactive oxygen species in mouse skin using L-012 as a probe

Liu Jiao-Li, Xue Qiao, Liu Chen-Guang, Bai Feng-Wu, Wada Satoshi, Wang Jin-Ye

FREE RADICAL RESEARCH 52 巻 ( 11-12 ) 頁： 1424 - 1431 2018年12月

Analysis of the involvement of cancer-associated fibroblasts in the progression of malignant mesothelioma

Ohara Yuuki, Enomoto Atsushi, Takahashi Masahide, Toyokuni Shinya

CANCER SCIENCE 109 巻頁： 454-454 2018年12月

Multifaceted roles of Ptger2 (Prostaglandin E receptor 2) in asbestos-induced inflammation and malignant mesothelioma

Jiang Li, Akatsuka Shinya, Toyokuni Shinya

CANCER SCIENCE 109 巻頁： 830-830 2018年12月

Inflammatory microenvironment derived from asbestos increases mutagenesis to repairing mesothelial cell

Ito Fumiya, Toyokuni Shinya

CANCER SCIENCE 109 巻頁： 830 - 830 2018年12月

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