研究者詳細 - 上山　純

論文 - 上山　純

分割表示 >> ／全件表示 131 件中 1 - 131 件目

Temporal trend and cross-sectional characterization of urinary concentrations of glyphosate in Japanese children from 2006 to 2015 査読有り

Nomura, H; Hamada, R; Wada, K; Saito, I; Nishihara, N; Kitahara, Y; Watanabe, S; Nakane, K; Nagata, C; Kondo, T; Kamijima, M; Ueyama, J

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 242 巻頁： 113963 2022年5月

Urinary concentrations and elimination half-lives of parabens, benzophenones, bisphenol and triclosan in Japanese young adults.

Nguyen HT, Isobe T, Iwai-Shimada M, Takagi M, Ueyama J, Oura K, Tanoue R, Kunisue T, Nakayama SF

Chemosphere 349 巻頁： 140920 2024年2月

Evaluating the risk of phthalate and non-phthalate plasticizers in dust samples from 100 Japanese houses

Shinohara, N; Oguri, T; Takagi, M; Ueyama, J; Isobe, T

ENVIRONMENT INTERNATIONAL 183 巻頁： 108399 2024年1月

Density predictive model for an outbreak in adult female Aedes albopictus (Diptera: Culicidae) in Japan

Watanabe, S; Nakane, K; Kitahara, Y; Nishihara, N; Nomura, H; Fukase, F; Uno, K; Kondo, T; Ueyama, J

JOURNAL OF MEDICAL ENTOMOLOGY 61 巻 ( 2 ) 頁： 418 - 426 2023年12月

Redox state of human serum albumin predicts 1-year prognosis in patients with heart failure: a single center prospective cohort study

Nishikawa, T; Ueyama, J; Miyata, S; Shimizu, S; Shibata, Y; Yamada, S

EUROPEAN HEART JOURNAL 44 巻 2023年11月

Association Between the Redox State of Human Serum Albumin and Exercise Capacity in Patients With Cardiac Disease 査読有り

Ishimaru, Y; Adachi, T; Ashikawa, H; Hori, M; Shimozato, T; Ohtake, H; Shimizu, S; Ueyama, J; Yamada, S

AMERICAN JOURNAL OF CARDIOLOGY 189 巻頁： 56 - 60 2023年2月

Effects of Pesticide Intake on Gut Microbiota and Metabolites in Healthy Adults 査読有り

Ueyama, J; Hayashi, M; Hirayama, M; Nishiwaki, H; Ito, M; Saito, I; Tsuboi, Y; Isobe, T; Ohno, K

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 20 巻 ( 1 ) 2023年1月

Interpreting biomonitoring data: Introducing the international human biomonitoring (i-HBM) working group's health-based guidance value (HB2GV) dashboard 査読有り国際共著

Nakayama, SF; St-Amand, A; Pollock, T; Apel, P; Bamai, YA; Barr, DB; Bessems, J; Calafat, AM; Castaño, A; Covaci, A; Duca, RC; Faure, S; Galea, KS; Hays, S; Hopf, NB; Ito, Y; Jeddi, MZ; Kolossa-Gehring, M; Kumar, E; LaKind, JS; López, ME; Louro, H; Macey, K; Makris, KC; Melnyk, L; Murawski, A; Naiman, J; Nassif, J; Noisel, N; Poddalgoda, D; Quirós-Alcalá, L; Rafiee, A; Rambaud, L; Silva, MJ; Ueyama, J; Verner, MA; Waras, MN; Werry, K

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 247 巻頁： 114046 2023年1月

Gut microbiota in dementia with Lewy bodies 査読有り

Nishiwaki, H; Ueyama, J; Kashihara, K; Ito, M; Hamaguchi, T; Maeda, T; Tsuboi, Y; Katsuno, M; Hirayama, M; Ohno, K

NPJ PARKINSONS DISEASE 8 巻 ( 1 ) 頁： 169 2022年12月

Association of Redox State of Human Serum Albumin with Severity in Patients with Heart Failure A Cross-Sectional Study 査読有り

Nishikawa, T; Shimizu, S; Kamiya, H; Ueyama, J; Yamada, S

INTERNATIONAL HEART JOURNAL 63 巻 ( 6 ) 頁： 1107 - 1114 2022年11月

Survey of Arsenic/Heavy Metals and Pesticide Residues in Edible Insects for Human Consumption or Supplied in Japan 査読有り

Kitahara, Y; Nomura, H; Nishihara, N; Ueda, T; Watanabe, S; Saito, I; Ueyama, J

FOOD HYGIENE AND SAFETY SCIENCE 63 巻 ( 4 ) 頁： 136 - 140 2022年8月

Short chain fatty acids-producing and mucin-degrading intestinal bacteria predict the progression of early Parkinson's disease 査読有り

Nishiwaki, H; Ito, M; Hamaguchi, T; Maeda, T; Kashihara, K; Tsuboi, Y; Ueyama, J; Yoshida, T; Hanada, H; Takeuchi, I; Katsuno, M; Hirayama, M; Ohno, K

NPJ PARKINSONS DISEASE 8 巻 ( 1 ) 頁： 65 2022年6月

Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development 査読有り

Tamura, S; Mukaide, M; Katsuragi, Y; Fujii, W; Odaira, K; Suzuki, N; Tsukiji, N; Okamoto, S; Suzuki, A; Kanematsu, T; Katsumi, A; Takagi, A; Ikeda, K; Ueyama, J; Hirayama, M; Suzuki-Inoue, K; Matsushita, T; Kojima, T; Hayakawa, F

JOURNAL OF BIOLOGICAL CHEMISTRY 298 巻 ( 5 ) 頁： 101833 2022年5月

Simultaneous quantification of pyrethroid metabolites in urine of non-toilet-trained children in Japan 査読有り

Ueyama, J; Ito, Y; Hamada, R; Oya, N; Kato, S; Matsuki, T; Tamada, H; Kaneko, K; Saitoh, S; Sugiura-Ogasawara, M; Ebara, T; Kamijima, M

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 27 巻 ( 0 ) 頁： 25 2022年

Intestinal <i>Collinsella</i> may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate 査読有り

Hirayama, M; Nishiwaki, H; Hamaguchi, T; Ito, M; Ueyama, J; Maeda, T; Kashihara, K; Tsuboi, Y; Ohno, K

PLOS ONE 16 巻 ( 11 ) 頁： e0260451 2021年11月

Human Nonmercaptalbumin Is a New Biomarker of Motor Function 査読有り

Ito, S; Nakashima, H; Ando, K; Kobayashi, K; Machino, M; Seki, T; Ishizuka, S; Kanbara, S; Inoue, T; Koshimizu, H; Fujii, R; Yamada, H; Ando, Y; Ueyama, J; Kondo, T; Suzuki, K; Hasegawa, Y; Imagama, S

JOURNAL OF CLINICAL MEDICINE 10 巻 ( 11 ) 2021年6月

Association of self-reported moderate vegetable juice intake with small decline in kidney function in a five-year prospective study 査読有り

Fujii, R; Kondo, T; Tsukamoto, M; Kawai, S; Sasakabe, T; Naito, M; Kubo, Y; Okada, R; Tamura, T; Hishida, A; Ueyama, J; Hayashi, Y; Ohnishi, J; Hamajima, N; Takeuchi, K; Wakai, K

NUTRITION 84 巻頁： 111114 2021年4月

Non-linear model analysis of the relationship between cholinesterase activity in rats exposed to 2, 2-dichlorovinyl dimethylphosphate (dichlorvos) and its metabolite concentrations in urine 査読有り

Sato, H; Ito, Y; Hanai, C; Nishimura, M; Ueyama, J; Kamijima, M

TOXICOLOGY 450 巻頁： 152679 2021年2月

Cumulative exposure assessment of neonicotinoids and an investigation into their intake-related factors in young children in Japan 査読有り

Oya, N; Ito, Y; Ebara, T; Kato, S; Ueyama, J; Aoi, A; Nomasa, K; Sato, H; Matsuki, T; Sugiura-Ogasawara, M; Saitoh, S; Kamijima, M

SCIENCE OF THE TOTAL ENVIRONMENT 750 巻頁： 141630 2021年1月

Occupational exposure limits for acetaldehyde, 2-bromopropane, glyphosate, manganese and inorganic manganese compounds, and zinc oxide nanoparticle, and the biological exposure indices for cadmium and cadmium compounds and ethylbenzene, and carcinogenicity, occupational sensitizer, and reproductive toxicant classifications 招待有り査読有り

Araki, A; Azuma, K; Endo, G; Endo, Y; Fukushima, T; Hara, K; Harada, K; Hori, H; Horie, S; Horiguchi, H; Ichiba, M; Ichihara, G; Ishitake, T; Ito, A; Ito, Y; Iwasawa, S; Kakamu, T; Kamijima, M; Karita, K; Kawai, T; Kawamoto, T; Kishi, R; Kumagai, S; Matsumoto, A; Miyagawa, M; Miyauchi, H; Morimoto, Y; Nagano, K; Naito, H; Nakajima, T; Nakano, M; Nomiyama, T; Okuda, H; Okuda, M; Omae, K; Sato, K; Sobue, T; Suwazono, Y; Takebayashi, T; Takeshita, T; Takeuchi, A; Takeuchi, A; Tanaka, S; Tsuji, M; Tsukahara, T; Ueno, S; Ueyama, J; Umeda, Y; Yamamoto, K; Yamano, Y; Yamauchi, T; Yano, E

JOURNAL OF OCCUPATIONAL HEALTH 63 巻 ( 1 ) 2021年1月

Optimization and validation of a highly sensitive method for determining glyphosate in human urine by solid-phase extraction and liquid chromatography with tandem mass spectrometry: a methodological study 査読有り

Nomura, H; Hamada, R; Saito, I; Nakane, K; Sawa, R; Ukai, M; Shibata, E; Sato, M; Kamijima, M; Ueyama, J

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 25 巻 ( 1 ) 頁： 83 2020年12月

Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson's Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder 査読有り

Nishiwaki, H; Hamaguchi, T; Ito, M; Ishida, T; Maeda, T; Kashihara, K; Tsuboi, Y; Ueyama, J; Shimamura, T; Mori, H; Kurokawa, K; Katsuno, M; Hirayama, M; Ohnoa, K

MSYSTEMS 5 巻 ( 6 ) 2020年11月

Meta-Analysisof Gut Dysbiosis in Parkinson's Disease 査読有り

Nishiwaki, H; Ito, M; Ishida, T; Hamaguchi, T; Maeda, T; Kashihara, K; Tsuboi, Y; Ueyama, J; Shimamura, T; Mori, H; Kurokawa, K; Katsuno, M; Hirayama, M; Ohno, K

MOVEMENT DISORDERS 35 巻 ( 9 ) 頁： 1626 - 1635 2020年9月

Within-individual and interlaboratory variability analyses of urinary metabolites measurements of organophosphorus insecticides 査読有り

Ito, Y; Ueyama, J; Nakayama, SF; Isobe, T; Oya, N; Sato, H; Ebara, T; Yoshimasu, K; Tsuno, K; Tatsuta, N; Nakai, K; Kamijima, M

JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY 30 巻 ( 4 ) 頁： 721 - 729 2020年7月

Within-individual and interlaboratory variability analyses of urinary metabolites measurements of organophosphorus insecticides 査読有り

Yuki Ito, Jun Ueyama, Shoji F Nakayama, Tomohiko Isobe, Naoko Oya, Hirotaka Sato, Takeshi Ebara, Kouichi Yoshimasu, Kanami Tsuno, Nozomi Tatsuta, Kunihiko Nakai, Michihiro Kamijima

J Expo Sci Environ Epidemiol 30 巻 ( 4 ) 頁： 721 - 729 2020年7月

Associations between Exposure to Tobacco Smoke and Behavioral Problems in Preschool Japanese Children 査読有り

Wada, K; Ueyama, J; Konishi, K; Goto, Y; Koda, S; Mizuta, F; Tamura, T; Watanabe, K; Ando, K; Kondo, T; Nagata, C

JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH 2020 巻頁： 7591263 2020年5月

Association between redox state of human serum albumin and exercise capacity in older women: A cross-sectional study 査読有り

Ashikawa, H; Adachi, T; Ueyama, J; Yamada, S

GERIATRICS & GERONTOLOGY INTERNATIONAL 20 巻 ( 3 ) 頁： 256 - 260 2020年3月

Ten-year temporal trends (2006-2015) and seasonal-differences in urinary metabolite concentrations of novel, hygiene-used pyrethroids in Japanese children. 査読有り

Hamada R, Ueda Y, Wada K, Saito I, Nomura H, Kamijima M, Nakane K, Nagata C, Kondo T, Ueyama J.

Int J Hyg Environ Health 225 巻頁： 113448 2020年1月

Occupational exposure limits for ethyl benzene, dimethyl terephthalate and hydrogen fluoride, and carcinogenicity and reproductive toxicant classifications The Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health

Araki, A; Azuma, KC; Endo, G; Endo, Y; Fukushima, T; Hara, K; Hori, H; Ichiba, M; Ishitake, T; Ichihara, G; Ito, A; Ito, Y; Iwasawa, S; Kakamu, T; Kamijima, M; Karita, K; Katoh, T; Kawai, T; Kawamoto, T; Kishi, R; Kumagai, S; Kusaka, Y; Miyagawa, M; Miyauchi, H; Morimoto, Y; Nagano, K; Naito, H; Nakajima, T; Nakano, M; Nomiyama, T; Okuda, H; Okuda, M; Omae, K; Sato, K; Sobue, T; Suwazono, Y; Takebayashi, T; Takeshita, T; Tsukahara, T; Tsunoda, M; Ueyama, J; Umeda, Y; Yamamoto, K; Yamano, Y; Yamauchi, T; Yano, E

JOURNAL OF OCCUPATIONAL HEALTH 62 巻 ( 1 ) 2020年1月

Biomonitoring method for neonicotinoid insecticides in urine of non-toilet-trained children using LC-MS/MS.

Ueyama J, Aoi A, Ueda Y, Oya N, Sugiura Y, Ito Y, Ebara T, Kamijima M

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 頁： 1-12 2019年12月

Prenatal exposure to organophosphate pesticides, maternal paraoxonase 1 genotype, and childhood neurodevelopment at 24 months of age in Shandong, China.

Wang Y, Zhang Y, Ji L, Zhou Y, Shi R, Kamijima M, Ueyama J, Gao Y, Tian Y

Environmental science and pollution research international 2019年11月

Freeze-drying enables homogeneous and stable sample preparation for determination of fecal short-chain fatty acids.

Ueyama J, Oda M, Hirayama M, Sugitate K, Sakui N, Hamada R, Ito M, Saito I, Ohno K

Analytical biochemistry 頁： 113508 2019年11月

Exposure levels of organophosphate pesticides in Japanese diapered children: Contributions of exposure-related behaviors and mothers' considerations of food selection and preparation.

Oya N, Ito Y, Ebara T, Kato S, Hioki K, Aoi A, Ueyama J, Oguri T, Shoji N, Sugiura-Ogasawara M, Saitoh S, Kamijima M

Environment international 134 巻頁： 105294 2019年11月

Cohort profile: Aichi regional sub-cohort of the Japan Environment and Children's Study (JECS-A) 査読有り

Takeshi Ebara, Yasuyuki Yamada, Naoto Shoji, Yuki Ito, Atsuko Nakagawa, Taishi Miyachi, Yasuhiko Ozaki, Toyonori Omori, Sadao Suzuki, Masayo Kojima, Jun Ueyama, Motohiro Tomizawa, Sayaka Kato, Tomoko Oguri, Taro Matsuki, Hirotaka Sato, Naoko Oya, Mayumi Sugiura-Ogasawara, Shinji Saitoh, Michihiro Kamijima

BMJ Open 9 巻 ( 11 ) 頁： e028105 2019年11月

Occupational exposure limits for cumene, 2,4-dichlorophenoxy acetic acid, silicon carbide whisker, benzyl alcohol, and methylamine, and carcinogenicity, occupational sensitizer, and reproductive toxicant classifications

Araki, A; Azuma, K; Endo, G; Endo, Y; Fukushima, T; Hara, K; Harada, K; Hori, H; Horie, S; Ichiba, M; Ichihara, G; Ikeda, M; Ito, A; Ito, Y; Iwasawa, S; Kakumu, T; Kamijima, M; Karita, K; Katoh, T; Kawai, T; Kawamoto, T; Kumagai, S; Kusaka, Y; Matsumoto, A; Miyagawa, M; Miyauchi, H; Morimoto, Y; Nagano, K; Naito, H; Nakajima, T; Nakano, M; Nomiyama, T; Okuda, H; Okuda, M; Omae, K; Sakurai, H; Sato, K; Sobue, T; Suwazono, Y; Takebayashi, T; Takeshita, T; Takeuchi, A; Takeuchi, A; Tanaka, M; Tanaka, S; Tsukahara, T; Tsunoda, M; Ueno, S; Ueyama, J; Umeda, Y; Yamamoto, K; Yamano, Y; Yamauchi, T; Yano, E

JOURNAL OF OCCUPATIONAL HEALTH 61 巻 ( 4 ) 頁： 328 - 330 2019年7月

Association between exposure to household smoking and dental caries in preschool children: a cross-sectional study.

Goto Y, Wada K, Konishi K, Uji T, Koda S, Mizuta F, Yamakawa M, Watanabe K, Ando K, Ueyama J, Kondo T, Nagata C

Environmental health and preventive medicine 24 巻 ( 1 ) 頁： 9 2019年1月

Intra-individual variations of organophosphate pesticide metabolite concentrations in repeatedly collected urine samples from pregnant women in Japan.

Hioki K, Ito Y, Oya N, Nakayama SF, Isobe T, Ebara T, Shibata K, Nishikawa N, Nakai K, Kamida T, Ueyama J, Sugiura-Ogasawara M, Kamijima M

Environmental health and preventive medicine 24 巻 ( 1 ) 頁： 7 2019年1月

Human Serum Albumin Redox State is Associated with Decreased Renal Function in a Community-Dwelling Population.

Fujii R, Ueyama J, Kanno T, Suzuki K, Hamajima N, Wakai K, Hasegawa Y, Kondo T

American journal of physiology. Renal physiology 2018年11月

A sensitive and efficient procedure for the high-throughput determination of nine urinary metabolites of pyrethroids by GC-MS/MS and its application in a sample of Japanese children

Ueda, Y; Oda, M; Saito, I; Hamada, R; Kondo, T; Kamijima, M; Ueyama, J

ANALYTICAL AND BIOANALYTICAL CHEMISTRY 410 巻 ( 24 ) 頁： 6207 - 6217 2018年9月

A new method for simultaneous quantification of fosphenytoin, phenytoin and its primary metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin in whole blood by ultra-performance liquid chromatography-tandem mass spectrometry.

Suzuki T, Ogawa T, Ueyama J, Iwai M, Kondo F, Seno H

Legal medicine (Tokyo, Japan) 34 巻頁： 64-69 2018年9月

Occupational Exposure Limits for ethylidene norbornene, ethyleneimine, benomyl, and 2,3-epoxypropyl methacrylate, and classifications on carcinogenicity

Araki, A; Azuma, K; Endo, G; Endo, Y; Fukushima, T; Hara, K; Hori, H; Horie, S; Horiguchi, H; Ichiba, M; Ichihara, G; Ikeda, M; Ishitake, T; Ito, A; Ito, Y; Iwasawa, S; Kakumu, T; Kamijima, M; Karita, K; Katoh, T; Kawai, T; Kawamoto, T; Kumagai, S; Kusaka, Y; Matsumoto, A; Miyagawa, M; Miyauchi, H; Morimoto, Y; Nagano, K; Naito, H; Nakajima, T; Nakano, M; Nomiyama, T; Okuda, H; Okuda, M; Omae, K; Sakurai, H; Sato, K; Sobue, T; Suwazono, Y; Takebayashi, T; Takeshita, T; Takeuchi, A; Takeuchi, A; Tanaka, M; Tanaka, S; Tsukahara, T; Tsunoda, M; Ueno, S; Ueyama, J; Umeda, Y; Yamamoto, K; Yamano, Y; Yamauchi, T; Yano, E

JOURNAL OF OCCUPATIONAL HEALTH 60 巻 ( 4 ) 頁： 333 - 335 2018年7月

Common variant of <i>BCAS3</i> is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese

Sakiyama, M; Matsuo, H; Nakaoka, H; Kawamura, Y; Kawaguchi, M; Higashino, T; Nakayama, A; Akashi, A; Ueyama, J; Kondo, T; Wakai, K; Sakurai, Y; Yamamoto, K; Ooyama, H; Shinomiya, N

BMC MEDICAL GENETICS 19 巻 ( 1 ) 頁： 96 2018年6月

Effects of processing and cooking on the reduction of dinotefuran concentration in Japanese rice samples.

Watanabe M, Ueyama J, Ueno E, Ueda Y, Oda M, Umemura Y, Tanahashi T, Ikai Y, Saito I

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 2018年3月

Oxidized human serum albumin as a possible correlation factor for atherosclerosis in a rural Japanese population: the results of the Yakumo Study

Fujii, R; Ueyama, J; Aoi, A; Ichino, N; Osakabe, K; Sugimoto, K; Suzuki, K; Hamajima, N; Wakai, K; Kondo, T

ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 23 巻 ( 1 ) 頁： 1 2018年1月

[Human Biomonitoring as a Useful Approach to Health Risk Assessment Compared with Occupational Exposure Assessment of Insecticide Intake: Fundamental Study Focused on Local Populations and Occupational Fields]. 招待有り査読有り

Ueyama J

Nihon eiseigaku zasshi. Japanese journal of hygiene 73 巻 ( 3 ) 頁： 247 - 256 2018年

(-)-Epigallocatechin-3-gallate Down-regulates Doxorubicin-induced Overexpression of P-glycoprotein Through the Coordinate Inhibition of PI3K/Akt and MEK/ERK Signaling Pathways. 査読有り

HANA SATONAKA, KUMIKI ISHIDA, MIHO TAKAI, RYOJI KOIDE, RYOTA SHIGEMASA, JUN UEYAMA, TETSUYA ISHIKAWA, KAZUHIKO HAYASHI, HIDEMI GOTO and SHINYA WAKUSAWA

Anticancer Res 37 巻 ( 11 ) 頁： 6071-6077 2017年11月

Nitric Oxide Plasma Level as a Barometer of Endothelial Dysfunction in Factory Workers

Miyata, S; Noda, A; Hara, Y; Ueyama, J; Kitaichi, K; Kondo, T; Koike, Y

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES 125 巻 ( 10 ) 頁： 684 - 689 2017年11月

Association Between Organophosphate Pesticide Exposure and Thyroid Hormones in Pregnant Women. 査読有り

Yiwen Wang; Limei Chen; Caifeng Wang; Yi Hum; Yu Gao; Yijun Zhou; Rong Shi; Yan Zhang; Michihiro Kamijima; Jun Ueyama; Ying Tian

Epidemiology 2017 巻 ( 28 ) 頁： S35–S40 2017年10月

Prenatal and postnatal exposure to organophosphate pesticides and childhood neurodevelopment in Shandong, China 査読有り

Yiwen Wang, Yan Zhang, Lin Ji, YiHu, Jingjing Zhang, Caifeng Wang, Guodong Ding, Limei Chen, Michihiro Kamijima, Jun Ueyama, Yu Gao c, Ying Tian

Environment International 108 巻頁： 119-126 2017年8月

Occupational exposure limits for ethylene glycol monobutyl ether, isoprene, isopropyl acetate and propyleneimine, and classifications on carcinogenicity, occupational sensitizer and reproductive toxicant. 招待有り査読有り

Kenichi Azuma, Ginji Endo, Yoko Endo, Tetsuhito Fukushima, Kunio Hara, Hajime Hori, Seichi Horie, Hyogo Horiguchi, Masayoshi Ichiba, Gaku Ichihara, Masayuki Ikeda, Tatsuya Ishitake, Akiyoshi Ito, Yuki Ito, Satoko Iwasawa, Michihiro Kamijima, Kanae Karita, Takahiko Katoh, Toshio Kawai, Toshihiro Kawamoto, Reiko Kishi, Shinji Kumagai, Yukinori Kusaka, Akiko Matsumoto, Muneyuki Miyagawa, Hiroyuki Miyauchi, Yasuo Morimoto, Kasuke Nagano, Hisao Naito, Tamie Nakajima, Tetsuo Nomiyama, Hirokazu Okuda, Kazuyuki Omae, Haruhiko Sakurai, Kazuhiro Sato, Tomotaka Sobue, Yasushi Suwazono, Toru Takebayashi, Tatsuya Takeshita, Akito Takeuchi, Ayano Takeuchi, Masatoshi Tanaka, Shigeru Tanaka, Teruomi Tsukahara, Masashi Tsunoda, Susumu Ueno, Jun Ueyama, Yumi Umeda, Yuko Yamano, Takenori Yamauchi and Eiji Yano

J Occup Health 59 巻 ( 4 ) 頁： 364-366 2017年6月

Quantitative analysis of organophosphate insecticide metabolites in urine extracted from disposable diapers of toddlers in Japan 査読有り

Oya, N; Ito, Y; Hioki, K; Asai, Y; Aoi, A; Sugiura, Y; Ueyama, J; Oguri, T; Kato, S; Ebara, T; Kamijima, M

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 220 巻 ( 2 ) 頁： 209 - 216 2017年3月

Modulation of immunological activity on macrophages induced by diazinon. 査読有り

Nanako Ogasawara, Miyoko Matsushima, Nami Kawamura, Kazuko Atsumi, Takehiro Yamaguchi, Haruka Ochi, Yuto Kusatsugu, Sayaka Oyabu, Naozumi Hashimoto, Yoshinori Hasegawa, Jun Ueyama, Tsutomu Kawabe

Toxicology 379 巻頁： 22-30 2017年1月

Exposure characterization of three major insecticide lines in urine of young children in Japan-neonicotinoids, organophosphates, and pyrethroids. 査読有り

Osaka A, Ueyama J, Kondo T, Nomura H, Sugiura Y, Saito I, Nakane K, Takaishi A, Ogi H, Wakusawa S, Ito Y, Kamijima M.

Environmental Research 147 巻頁： 89-96 2016年5月

Temporal Levels of Urinary Neonicotinoid and Diaklyphosphate Concentrations in Japanese Women Between 1994-2011 査読有り

Jun Ueyama, Kouji H Harada, Akio Koizumi, Yuka Sugiura, Takaaki Kondo, Isao Saito, and Michihiro Kamijima

Environmental Science & Tachinology 49 巻 ( 24 ) 頁： 14522-14528 2015年12月

Effects of Paraoxonase 1 gene polymorphisms on organophosphate insecticide metabolism in Japanese pest control workers. 査読有り

Sato H, Ito Y, Ueyama J, Kano Y, Arakawa T, Gotoh M, Kondo T, Sugiura Y, Saito I, Shibata E, Kamijima M.

Journal of Occupational Health 58 巻 ( 1 ) 頁： 56-65 2015年12月

Lack of contribution of multidrug resistance-associated protein and organic anion-transporting polypeptide to pharmacokinetics of Regorafenib, a novel multi-kinase inhibitor, in rats. 査読有り

HOTTA Kazuo, UEYAMA Jun, TATSUMI Yasuaki, YSUKIYAMA Ikuto, SUGIURA Yuka, SAITO Hiroko, MATSUURA Katsuhiko, HASEGAWA Takaaki

Anticancer Res 35 巻 ( 9 ) 頁： 4681-4689 2015年9月

Comparison of different urine pretreatments for biological monitoring of pyrethroid insecticides. 査読有り

TOSHIMA Hiroki, YOSHINAGA Jun, SHIRAISHI Hiroaki, ITO Yuki, KAMIJIMA Michihiro, UEYAMA Jun

Journal of Analytical Toxicology 39 巻 ( 2 ) 頁： 133-136 2015年3月

Biological Monitoring Method for Urinary Neonicotinoid Insecticides Using LC-MS/MS and Its Application to Japanese Adults. 査読有り

UEYAMA Jun, NOMURA Hiroshi, KONDO Takaaki, SAITO Isao, ITO Yuki, OSAKA Aya, KAMIJIMA Michihiro

Journal of Occupational Health 56 巻頁： 461-468 2015年1月

A revised method for determination of dialkylphosphate levels in human urine by solid-phase extraction and liquid chromatography with tandem mass spectrometry: application to human urine samples from Japanese children. 査読有り

UEYAMA Jun, SAITO Isao, TAKAISHI Akiko, NOMURA Hiroshi, NOUE Mai, OSAKA Aya, SUGIURA Yuka, HAYASHI Yumi, WAKUSAWA Shinya, OGI Hiroko, INUZUKA Kimio, KAMIJIMA Michihiro, KONDO Takaaki

Environmental Health and Preventive Medicine 19 巻 ( 6 ) 頁： 405-413 2014年11月

Contribution of plasma proteins, albumin and alpha 1-acid glycoprotein, to pharmacokinetics of a multi-targeted receptor tyrosine kinase inhibitor, sunitinib, in analbuminemic rats. 査読有り

TOYAMA Yukio, UEYAMA Jun, NOMURA Hiroshi, TSUKIYAMA Ikuto, SAITO Hiroko, HISADA Tatsuya, MATSUURA Katsuhiko, HASEGAWA Takaaki

Anticancer Res 34 巻 ( 5 ) 頁： 2283-2289 2014年6月

A non-invasive biomonitoring method for assessing levels of urinary pyrethroid metabolites in diapered children by gas chromatography-mass spectrometry. 査読有り

SAITO Shun, UEYAMA Jun, KONDO Takaaki, SAITO Isao, SHIBATA Eiji, GOTOH Masahiro, NOMURA Hiroshi, WAKUSAWA Shinya, NAKAI Kunihiko, KAMIJIMA Michihiro.

J Expo Sci Environ Epidemiol 24 巻 ( 2 ) 頁： 200-7 2014年3月

A revised method for determination of serum mercaptalbumin and nonmercaptalbumin by high performance liquid chromatography coupled with post-column bromocresol green reaction. 査読有り

UEYAMA Jun, ISHIKAWA Yusuke, KONDO Takaaki, MOTOYAMA Megumi, MATSUMOTO Hiroyuki, MATSUSHITA Tadashi

Ann Clin Biochem. in press 巻頁： in press 2014年3月

Biochemical staging of the chronic hepatic lesions of Wilson disease. 査読有り

Katano Y, Hayashi K, Hattori A, Tatsumi Y, Ueyama J, Wakusawa S, Yano M, Toyoda H, Kumada T, Mizutani N, Hayashi H, Goto H.

Nagoya J Med Sci. 76 巻 ( 1-2 ) 頁： 139-148 2014年2月

Ursodeoxycholic acid inhibits overexpression of P-glycoprotein induced by doxorubicin in HepG2 cells. 査読有り

Komori Y, Arisawa S, Takai M, Yokoyama K, Honda M, Hayashi K, Ishigami M, Katano Y, Goto H, Ueyama J, Ishikawa T, Wakusawa S.

Eur J Pharmacol. 724 巻頁： 161-167 2014年2月

Quantitation of neonicotinoid metabolites in human urine using GC-MS. 査読有り

NOMURA Hiroshi, UEYAMA Jun, KONDO Takaaki, SAITO Isao, MURATA Katsuyuki, IWATA Toyoto, WAKUSAWA Shinya, KAMIJIMA Michihiro

Journal of Chromatography B 941 巻頁： 109-115 2013年12月

Drug interaction between sunitinib and cimetidine and contribution of the efflux transporter ATP-binding cassette C2 to biliary excretion of sunitinib in rats. 査読有り

ARAKAWA-TODO Mika, UEYAMA Jun, NOMURA Hiroshi, ABE Fumie, TSUKIYAMA Ikuto, MATSUURA Katsuhiko, HASEGAWA Takaaki

Anticancer Research 33 巻 ( 8 ) 頁： 3089-3097 2013年8月

Preparation of dealcholized onetaxotere®, docetaxel injection formulation and its pharmacokinetics in rats. 査読有り

Onishi Katsuhiro, TSUKIYAMA Ikuto, UEYAMA Jun, ABE Fumie, SAITO Hiroko, MATSUURA Katsuhiko, NADAI Masayuki, HASEGAWA Takaaki

Gan To Kagaku Ryoho. 40 巻 ( 7 ) 頁： 891-986 2013年7月

Various copper and iron overload patterns in the livers of patients with Wilson disease and idiopathic copper toxicosis 査読有り

HAYASHI Hisao, HATTORI Ai, TATSUMI Yasuaki, HAYASHI Kazuhiko, KATANO Yoshiaki, UEYAMA Jun, WAKUSAWA Shinya, YANO Motoyoshi, GOTO Hidemi

Med Mol Morphol. 22 巻頁： 00-00 2013年1月

Evidence for diazinon-mediated inhibition of cis-permethrin metabolism and its effects on reproductive toxicity in adult male mice 査読有り

WANG Dong, KAMIJIMA Michihiro, OKAMURA Ai, ITO Yuki, YANAGIBA Yukie, JIA Xiao-fang, NAITO Hisao, UEYAMA Jun, NAKAJIMA Tamie

Reprod Toxicol. 34 巻頁： 489-497 2012年12月

Urinary concentrations of organophosphorus insecticide metabolites in Japanese workers 査読有り

UEYAMA Jun, SAITO Isao, KONDO Takaaki, TAKI Tomoko, KIMATA Akiko, SAITO Shun, ITO Yuki, MURATA Katsuyuki, IWATA Toyoto, GOTOH Masahiro, SHIBATA Eiji, WAKUSAWA Shinya, KAMIJIMA Michihiro

Chemosphere 87 巻頁： 1403-1409 2012年6月

Prevalence of Helicobacter Pylori Infection Measured with Urinary Antibody in an Urban Area of Japan, 2008-2010 査読有り

TAMURA Takashi, MORITA Emi, KONDO Takaaki, UEYAMA Jun, TANAKA Tetsuya, KIDA Yuto, HORI Yoko, INOUE Shigeru, TOMITA Koutaro, OKADA Rieko, KAWAI Sayo, HISHIDA Asahi, NAITO Mariko, WAKAI Kenji and HAMAJIMA Nobuyuki

Nagoya Journal of Medical Science 74 巻頁： 63-70 2012年2月

New analytical method for sensitive quantification of urinary 3-methyl-4-nitrophenol to assess fenitrothion exposure in general population and occupational sprayers 査読有り

OKAMURA Ai, SAITO Isao, UEYAMA Jun, ITO Yuki, NAKAJIMA Tamie, KAMIJIMA Michihiro

Toxicol Lett. 210 巻 ( 2 ) 頁： 220-224 2011年11月

Panipenem does not alter the pharmacokinetics of the active metabolite of irinotecan SN-38 and inactive metabolite SN-38 glucuronide (SN-38G) in rats 査読有り

KATO Ayako, UEYAMA Jun, ABE Fumie, HOTTA Kazuo, TSUKIYAMA Ikuo, OSHIMA Taeyuki, KONDO F, SAITO Hiroko, HASEGAWA Takaaki.

Anticancer Res. 31 巻 ( 9 ) 頁： 2915-2922 2011年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

PubMed ID21868538
The present study has investigated the effect of panipenem, a widely used antibiotic, on the pharmacokinetics of an active metabolite of irinotecan (CPT-11), 7-ethyl-10-hydroxy-camptothecin (SN-38) and SN-38 glucuronide (SN-38G) produced by uridine-diphosphate glucuronosyltransferase (UGT) 1A isoform-mediated glucuronidation in rats. Rats received a 1 h infusion with panipenem at a loading dose of 10 mg/kg and a maintenance dose of 15 mg/min/kg once a day for 5 days. When the effect of pretreatment with panipenem on glucuronidation activities of substrates for hepatic UGT1A isoforms was investigated using substrates 4-methylumbelliferone (4MU), estradiol and SN-38, the rate of 4MU glucuronide formation was significantly increased, but that of estradiol glucuronide formation was unchanged. However, the rate of SN-38G formation showed a tendency to increase. One hour after the final infusion of panipenem or saline, SN-38 (2 mg/kg) was administered intravenously in rats with or without bile duct cannulation. Pretreatment with panipenem had no effect on the plasma concentration-time curves and biliary excretion of SN-38 and SN-38G in rats with and without bile duct cannulation. There were also no significant differences in the relative extent of glucuronidation of SN-38 to SN-38G (AUC(2 h, SN-38G)/AUC(2 h, SN-38)) between panipenem-treated and untreated rats. These findings suggest that pretreatment with panipenem does not alter the pharmacokinetics of SN-38 and SN-38G, suggesting the possibility that panipenem can be used safely for cancer patients undergoing irinotecan chemotherapy.

Study Profile on Baseline Survey of Daiko Study in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) 査読有り

MORITA Emi, HAMAJIMA Nobuyuki, HISHIDA Asahi, AOYAMA Kyoko, OKADA Rieko, KAWAI Sayo, TOMITA Koutaro, KURIKI Sayaka, TAMURA Takashi, NAITO Mariko, KONDO Takaaki, UEYAMA Jun, KIMATA Akiko, YAMAMOTO Kanami, HORI Yoko, HOSHINO Junko, HAMAMOTO Ritsuko, TSUKAMOTO Sanae, ONISHI Johji, HAGIKURA Shoichi, NAITO Hisao, HIBI Satoshi, ITO Yoshinori and WAKAI Kenji

Nagoya Journal of Medical Science 73 巻頁： 187-195 2011年8月

Effect of DDVP on urinary excretion levels of pyrethroid metabolite 3-phenoxybenzoic acid in rats 査読有り

HIROSAWA Naoko, UEYAMA Jun, KONDO Takaaki, KAMIJIMA Michihiro, TAKAGI Kenji, FUJINAKA Sanae, HIRATE Ayaka, HASEGAWA Takaaki, WAKUSAWA Shinya.

Toxicol Lett. 203 巻 ( 1 ) 頁： 28-32 2011年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

PubMed ID:21471973
Pyrethroid insecticide (PYR) is used worldwide in agriculture and for indoor extermination of harmful insects. Urinary PYR metabolites (e.g. 3-phenoxybenzoic acid, 3PBA) have been used as the most sensitive biomarker for environmental PYR exposure since the late 1990's. In this study, we examined the effect of organophosphorus insecticide (OP) dichlorvos (DDVP) on excretion levels of urinary cis-permethrin-derived 3PBA in rats. Concentration of urinary 3PBA and cis-permethrin in plasma were monitored using gas chromatography-mass spectrometry and high-performance liquid chromatography after cis-permethrin injection (20mg/kg) via the tail vein of rats pretreatmented intraperitoneally with DDVP (low dose, 0.3mg/kg; high dose, 1.5mg/kg). The amount of urinary 3PBA excretion over 48h after cis-permethrin administration in control was 21.5±5.1μg (mean±S.D.). In the low- and high-dose DDVP groups, the amounts of urinary 3PBA excretion were decreased to 81.1% (17.4±2.7μg) and 70.3% (15.1±2.6μg) of control, respectively. The plasma concentrations of cis-permethrin-derived 3-phenoxybenzyl alcohol (3PBAlc), which is a metabolite derived following hydrolysis of cis-permethrin, in high-dose DDVP group (0.18±0.01μg) were significantly lower than in control (0.23±0.03μg) 1h after cis-permethrin injection. Both in the control and high-dose DDVP group, no differences were observed in the excretion levels of urinary 3PBA after injection of 3PBAlc (25mg/kg, i.v). These results suggested that the effect of DDVP on the amount of urinary 3PBA excretion was caused by the DDVP-induced modification of the cis-permethrin metabolic pathway. In conclusion, the possible decrease in urinary excretion level of 3PBA due to co-exposure to OPs should be considered in the biological monitoring of PYR exposure.

Mechanism underlying the efficacy of combination therapy with losartan and hydrochlorothiazide in rats with salt-sensitive hypertension. 査読有り

YAMADA Yuichiro, TSUBOI Koji, HATTORI Takuya, MURATE Takashi, OHTAKE Masafumi, FRUKAWA Mayuko, UEYAMA Jun, NISHIYAMA Akira, MUROHARA Toyoaki, NAGATA Kohzo.

Hypertens Res 34 巻 ( 7 ) 頁： 809-816 2011年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

PubMed ID21471973
Although thiazide diuretics are commonly used to supplement angiotensin receptor blockers for treatment of hypertension, the mechanism underlying the therapeutic effects of this drug combination remains unclear. We investigated the antihypertensive and cardioprotective effects of combination therapy with losartan (LOS) and hydrochlorothiazide (HCTZ), in comparison with those of either drug alone, in Dahl salt-sensitive hypertensive rats. Rats fed a high-salt diet from 6 weeks of age were treated with LOS, HCTZ, both drugs (COMB) and vehicle from 6 to 11 weeks. The salt-induced increase in systolic blood pressure was attenuated moderately by LOS and to a greater extent by HCTZ and COMB. Left ventricular (LV) hypertrophy and fibrosis, diastolic dysfunction, as well as angiotensin-converting enzyme and angiotensin II type 1A (AT(1A)) receptor gene expression were attenuated similarly by LOS and HCTZ and more so by COMB. LOS downregulated expression of the AT(1A) receptor gene, without affecting that of the AT(2) receptor gene, in the aorta. In contrast, neither HCTZ nor COMB affected aortic expression of the AT(1A) receptor gene, but both markedly upregulated that of the AT(2) receptor gene. The salt-induced decrease in the plasma concentration of nitric oxide metabolites was attenuated substantially by LOS and abolished by both HCTZ and COMB. In conclusion, the combination of LOS and HCTZ attenuated hypertension, as well as LV remodeling and diastolic dysfunction, more effectively than did LOS or HCTZ alone in rats with salt-sensitive hypertension. Modulation of the cardiac and vascular renin-angiotensin system may have contributed to these beneficial effects of the drug combination.

Association of UGT1A1 Gly71Arg with urine urobilinogen 査読有り

KATAOKA Ryuji, KIMATA Akiko, YAMAMOTO Kanami, HIROSAWA Naoko, UEYAMA Jun, KONDO Takaaki, OKADA Rieko, KAWAI Sayo, HISHIDA Asahi, NAITO Mariko, MORITA Emi, WAKITA Kenji, HAMAJIMA Nobuyuki

Nagoya Journal of Medical Science 73 巻 ( 1-2 ) 頁： 33-40 2011年4月

Involvement of sulfate conjugation and multidrug resistance-associated protein 2 (MRP2) in sex-related differences in the pharmacokinetics of garenoxacin in rats 査読有り

HAYASHI Tamon, ABE Fumie, KATO Miki, SAITO Hiroko, UEYAMA Jun, KONDO Yuya, IMAI Kuniyuki, KATOH Miki, NADAI Masayuki, HASEGAWA Takaaki

J Infect Chemother 17 巻 ( 1 ) 頁： 24-29 2011年2月

Beta-glucuronidase activity is a more sensitive biomarker than cholinesterase inhibition for organophosphorus insecticide exposure 査読有り

UEYAMA Jun, SATOH Tetsuo, KONDO Takaaki, TAKAGI Kenji, SHIBATA Eiji, GOTO Masahiro, KIMATA Akiko, SAITO Isao, HASEGAWA Takaaki, WAKUSAWA Shinya, KAMIJIMA Michihiro.

Toxicol Lett 193 巻 ( 1 ) 頁： 115-119 2010年12月

Endotoxin does not alter the pharmacokinetics of micafungin,but it impairs biliary excretion of micafungin via multidrugresistance-associated protein 2 (ABCC2/Mrp2) in rats 査読有り

NODA Takayuki, ABE Fumie, UEYAMA Jun, KATO Miki, KATOH Miki, NADAI Masayuki, SAITO Hiroko, HASEGAWA Takaaki

J Infect Chemother 2010年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

PubMed ID:20835743
Micafungin, a newly developed echinocandin-type antifungal agent, is widely used for the treatment of deep-seated fungal infections including those of Candida species and Aspergillus species. In the present study, the possible alterations in the pharmacokinetics and biliary excretion of micafungin were investigated in endotoxemic rats induced by Klebsiella pneumoniae endotoxin. Endotoxin (2 mg/kg) was injected intraperitoneally 24 h before an intravenous injection of micafungin (1 mg/kg). No significant differences in the plasma concentration-time curves and pharmacokinetic parameters of micafungin were observed between endotoxin-treated and endotoxin-untreated rats. When endotoxin-treated rats received a constant-rate infusion of micafungin, the biliary clearance of micafungin was significantly decreased, whereas the steady-state plasma concentration did not change. By protein immunoblot analysis, a significant decrease in the expression of hepatic multidrug resistance-associated protein 2 (ABCC2/Mrp2), which is an efflux protein for micafungin, was observed in endotoxin-treated rats. These results suggest that endotoxin-induced decrease in the hepatobiliary excretion of micafungin is caused, at least in part, by the reduction of Mrp2-mediated hepatobiliary transport ability. The present study may provide information suggesting that micafungin can be used for patients with endotoxemia without the need for dosage adjustment.

DOI： 10.1007/s10156-010-0118-9

Preliminary study on spontaneous hepatitis in long-evans cinnamon rats: a blood echange may improve the fetal hepatitis 査読有り

UEYAMA Jun, WAKUSAWA Shinya, TATSUMI Yasuyuki, HATTOEI Ai, YANO Motoyoshi, HAYASHI Hisao

Nagoya J Med Sci 72 巻 ( 3-4 ) 頁： 173-177 2010年8月

Toxicokinetics of pyrethroid metabolites in male and female rats 査読有り

UEYAMA Jun, HIROSAWA Naoko, MOCHIZUKI Aiko, KIMATA Akiko, KAMIJIMA Michihiro, KONDO Takaaki, TAKAGI Kenji, WAKUSAWA Shinya, HASEGAWA Takaaki

Environmental Toxicology and Pharmacology 30 巻 ( 1 ) 頁： 88-91 2010年7月

Revised method for routine determination of urinary dialkyl phosphates using gas chromatography-mass spectrometry 招待有り査読有り

UEYAMA Jun, KAMIJIMA Michihiro, KONDO Takaaki, TAKAGI Kenji, SHIBATA Eiji, HASEGAWA Takaaki, WAKUSAWA Shinya, TAKI Tomoko, GOTO Masahiro, SAITO Isao

J Chromatogra B 878 巻 ( 17-18 ) 頁： 1257-1263 2010年5月

Analysis and evaluation of pyrethroid exposure in human population based on biological monitoring of urinary pyrethroid metabolites 査読有り

UEYAMA Jun, SAITO Isao, KAMIJIMA Michihiro

Journal of Pesticide Science 35 巻 ( 2 ) 頁： 87-98 2010年4月

健常成人における成熟にんにくの血管内皮機能へ及ぼす影響査読有り

宮田聖子、野田明子、永井万由佳、大嶽正文、上山純、古池保雄

日本臨床生理学会雑誌 40 巻 ( 2 ) 頁： 103-108 2010年4月

Measurement of forearm blood flow of healthy young men and women using strain-gauge plethysmography 査読有り

KONDO Takaaki, YAMADA Chie, FURUTA Takako, YOSHITAKE Junko, SHIROTORI AYA, OKADA Yoshiko, KIMATA Akiko, YAMAMOTO Kanami, UEYAMA Jun, SAKAKIBARA Hisataka, FUKAYA Yukio

Bull Aichi Bunkyo Women's Coll 31 巻頁： 27-34 2010年3月

Comparison of urinary concentrations of 3-phenoxybenzoic acid among general residents in rural and suburban areas and employees of pest control firms 査読有り

KIMATA Akiko, KONDO Takaaki, UEYAMA Jun, YAMAMOTO K, YOSHITAKE Junko, TAKAGI Kenji, SUZUKI Koji, INOUE Takashi, ITO Yoshinori, HAMAJIMA Nobuyuki, KAMIJIMA Michihiro, GOTOH Masahiro, SHIBATA Eiji.

Int Arch Occup Environ Health 82 巻 ( 10 ) 頁： 1173-1178 2009年11月

Broken sperm, cytoplasmic droplets and reduced sperm motility are principal markers of decreased sperm quality due to organophosphorus pesticides in rats 査読有り

OKAMURA Ai, KAMIJIMA Michihiro, OHTANI Katsumi, YAMANOSHITA Osamu, NAKAMURA Daichi, ITO Yuki, MIYATA Maiko, UEYAMA Jun, SUZUKI Takayoshi, IMAI Ryota, TAKAGI Kenji, NAKAJIMA Tamie.

J Occup Health 51 巻 ( 6 ) 頁： 478-487 2009年9月

Relationship between dietary habits and urinary concentrations of 3-phenoxybonzoic acid in a middle-aged and elderly general population in Japan 査読有り

KIMATA Akiko, KONDO Takaaki, UEYAMA Jun, YAMAMOTO Kanami, KAMIJIMA Michihiro, SUZUKI Koji INOUE Takashi, ITO Yoshinori, HAMAJIMA Nobuyuki.

Environ Health Prev Med 14 巻 ( 3 ) 頁： 173-179 2009年5月

Possible involvement of interleukin-6 (IL-6) in down-regulation of hepatic breast cancer resistance protein (Bcrp/ABCG2) in endotoxemic mice 査読有り

ZHAO Ying Lan, CEN X, ABE Fumie, UEYAMA Jun, HOTTA K, KATO S, ITO S, SAGA S, FUKAYA Yukio, WANG L, WEI Y, HASEGAWA Takaaki

Bull Aichi Bunkyo Women's Coll 30 巻頁： 27-42 2009年3月

Multilevel analyses of effects of variation in body mass index on serum lipid concentrations in middle-aged Japanese men 査読有り

KONDO Takaaki, KIMATA Akiko, YAMAMOTO Kanami, UEYAMA Sayoko, UEYAMA Jun, Yatsuya H, TAMAKOSHI K, HORI Yoko

Nagoya J Med Sci. 71 巻 ( 1-2 ) 頁： 19-28 2009年2月

Urinary excretion of 3-phenoxybenzoic acid in middle-aged and elderly general population of Japan 査読有り

UEYAMA Jun, KIMATA Akiko, KAMIJIMA Michihiro, HAMAJIMA Nobuyuki, ITO Yuki, SUZUKI Koji, INOUE Takashi, YAMAMOTO Kanami, TAKAGI Kenji, SAITO Isao, MIYAMOTO K, HASEGAWA Takaaki, KONDO Takaaki

Environ Res 109 巻 ( 2 ) 頁： 175-180 2009年2月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

Limited data are available on the background levels of exposure to synthetic pyrethroid (PYR) in Japan, despite their frequent application for agriculture and indoor extermination and possible effects of chronic and/or low-dose PYR exposure on human health. This study was conducted to describe the level and distribution of one of the major PYR metabolites, 3-phenoxybenzoic acid (3-PBA), in urine samples collected from a general population in Japan. The subjects were 535 individuals (184 men and 351 women; 61.5+/-9.8 years of age, mean+/-S.D.) residing in a town in Hokkaido, a dairy and agricultural area. Urinary 3-PBA was found detectable in 98% of samples above the limit of detection of 0.02 microg/l. The geometric mean values of urinary 3-PBA in occupationally exposed farmers (n=87) and the remaining general group without occupational exposure (n=448) were 0.38 and 0.29 microg/l, respectively, ranging from <LOD to 17.09 microg/l. No significant differences in urinary 3-PBA concentrations were shown between these two groups. Moreover, 3-PBA concentrations were found comparable to those reported in some countries. The present study is, to our knowledge, the first report of a biological monitoring study of urinary 3-PBA, which elucidated the background environmental exposure level of PYR in the Japanese general population without occupational exposure. Further nationwide studies covering different seasons and age distribution are needed to monitor the urinary 3-PBA levels in Japan.

Effects of short-term variation in body mass index on blood pressure in middle-aged Japanese male workers. 査読有り

KONDO Takaaki, KIMATA Akiko, YAMAMOTO Kanami, UEYAMA Sayoko, UEYAMA Jun, HORI Yoko

J Health Sci 55 巻 ( 1 ) 頁： 62-71 2009年2月

Relationship between urinary pesticide metabolites and pest control operation among occupational pesticide sprayers 査読有り

KIMATA Akiko, KONDO Takaaki, UEYAMA Jun, YAMAMOTO Kanami, KAMIJIMA Michihiro, SUZUKI Koji, INOUE Takashi, ITO Yuki, HAMAJIMA Nobuyuki.

J Occup Health 51 巻 ( 1 ) 頁： 100-105 2009年1月

Use of waist circumference and ultrasonographic assessment of abdominal fat distribution in predicting metabolic risk factors in healthy Japanese adults 査読有り

KONDO Takaaki, ABE Maimi, UEYAMA Jun, KIMATA Akiko, YAMAMOTO Kanami, HORI Yoko.

J Physiol Anthropo 28 巻 ( 1 ) 頁： 7-14 2009年1月

Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells 査読有り

ARISAWA Sakiko, ISHIDA Kumiki, KAMEYAMA Natsumi, UEYAMA Jun, HATTORI Ai, TATSUMI Yasuaki, HAYASHI Hisao, YANO Motoyoshi, HAYASHI Kazuhiko, KATANO Yoshiaki, GOTO Hidemi, TAKAGI Kenji, WAKUSAWA Shinya

Biochem Pharmacol 77 巻 ( 5 ) 頁： 858-866 2009年1月

Effect of the organophosphorus pesticide diazinon on glucose tolerance in type 2 diabetic rats 査読有り

UEYAMA Jun, KAMIJIMA Michihiro, ASAI Kazumi, MOCHIZUKI Aiko, WANG Dong, KONDO Takaaki, SUZUKI Takayuki, TAKAGI Kenji, TAKAGI Kenji, KANAZAWA Hiroaki, MIYAMOTO Ken-ichi, WAKUSAWA Shinya, HASEGAWA Takaaki.

Toxicol Lett 182 巻 ( 1-3 ) 頁： 42-47 2008年11月

Role of plasma proteins in pharmacokinetics of micafungin, an antifungal antibiotic, in analbuminemic rats 査読有り

ABE Fumie, UEYAMA Jun, KAWASUMI Noriyo, NADAI Masayuki, HAYASHI Tamon, KATO Miki, OHNISHI Masafumi, SAITO Hiroko, TAKEYAMA Naoshi, HASEGAWA Takaaki.

Antimicrob Agents Chemother 52 巻 ( 9 ) 頁： 3454-3456 2008年9月

Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats 査読有り

ABE Fumie, UEYAMA Jun, KIMATA Akiko, KATO Miki, Hayashi T, NADAI Masayuki, SAITO Hiroko, TAKEYAMA Naoshi, NOGUCHI Hiroshi, HASEGAWA Takaaki.

Life Sci 83 巻 ( 7-8 ) 頁： 229-235 2008年8月

Effect of thalidomide on endotoxin-induced decreases in activity and expression of hepatic cytochrome P450 3A2 査読有り

UEYAMA Jun, NADAI Masayuki, ZHAO Ying Lan, KANAZAWA Hiroaki, TAKAGI Kenji, KONDO Takaaki, TAKAGI Kenzo, WAKUSAWA Shinya, ABE Fumie, SAITO Hiroko, MIYAMOTO K, HASEGAWA Takaaki.

Biol Pharm Bull 31 巻 ( 8 ) 頁： 1596-1600 2008年8月

Involvement of -pro-inflammatory mediators in endotoxin-induced overproduction of inducible nitric oxide synthase and decrease in expression of hepatic cytochrome P450 査読有り

UEYAMA Jun, WAKUSAWA Shinya, FUKAYA Yukio, HASEGAWA Takaaki.

Bull Aichi Bunkyo Women's Coll 29 巻頁： 39-49 2008年3月

Permethrin may induce adult male mouse reproductive toxicity due to cis isomer not trans isomer 査読有り

ZHANG Shu-Yun, UEYAMA Jun, ITO Yuki, YANAGIBA Yukie, OKAMURA Ai, KAMIJIMA Michihiro, NAKAJIMA Tamie.

Toxicology 248 巻 ( 2-3 ) 頁： 136-141 2008年3月

Acute effect of exercise on blood pressure among fitness facility users, with special reference to influence of body mass index 査読有り

KONDO Takaaki, UEYAMA Jun, KIMATA Akiko, YAMAMOTO K, FUKAYA Yukio.

Bull Aichi Bunkyo Women's Coll 29 巻頁： 27-37 2008年3月

Increase in P-glycoprotein accompanied by activation of protein kinase C alpha and NF-kappa B p65 in the livers of rats with streptozotocin-induced diabetes 査読有り

KAMEYAMA Natsumi, ARISAWA Sakiko, UEYAMA Jun, KAGOTA Satomi, SHINOZUKA Kazumasa, HATTORI Ai, TATSUMI Yasuaki, HAYASHI Hisao, TAKAGI Kenji, WAKUSAWA Shinya

Biochim Biophys Acta 1782 巻 ( 5 ) 頁： 355-360 2008年3月

Association of serum NOx level with clustering of metabolic syndrome components in middle-aged and elderly general populations in Japan 査読有り

UEYAMA Jun, KONDO Takaaki, IMAI Ryota, KIMATA Akiko, YAMAMOTO Kanami, SUZUKI Koji, INOUE Takashi, ITO Yoshinori, MIYAMOTO Ken-ichi, HASEGAWA Takaaki, HAMAJIMA Nobuyuki.

Environ Health Prev Med 13 巻 ( 1 ) 頁： 36-42 2008年1月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

The results of ANCOVA confirmed that the serum lnNO( x ) level was significantly correlated with the clustering of MetS components in both men and women (p < 0.0001 for trend). CONCLUSION: Our results suggest that an increase in the clustering of MetS components was associated with the increase in serum NO levels in our general population.

Association of glycemic profiles with whole blood polyamine among middle-aged Japanese men: colorimetric assay using oat and barley seedling polyamine oxidase 査読有り

KONDO Takaaki, YAMAMOTO Kanami, KIMATA Akiko, UEYAMA Jun, HORI Yoko, TAKAGI Kenji.

Environ Health Prev Med 13 巻 ( 1 ) 頁： 43-51 2008年1月

Direct analysis of permethrins in human blood by SPE-GC/MS 査読有り

OGATA-KAWATA H, MATSUDA M, ONDA N, UEYAMA Jun, KAMIJIMA Michihiro, SHIBATA Eiji, OGAWA M, ENDO Y.

Chromatography 28 巻 ( 3 ) 頁： 119-124 2007年12月

健常成人男性で体重が血圧に与える影響－経年的測定データの多重レベル解析－査読有り

近藤高明, 上山純, 木全明子, 山本佳那実, 堀容子.

厚生の指標 54 巻 ( 13 ) 頁： 7-13 2007年11月

記述言語：日本語掲載種別：研究論文（学術雑誌）

職域集団の男性4,588名の1997年から2000年の健診受診データを用いて，血圧変動と体重変動との関連を多重レベルモデルにより解析した。BMIの変動は収縮期血圧，拡張期血圧とも有意に正の関連を示した。またその切片と傾きには個人間変動が有意に大きいことを明らかにした。

Biological monitoring of pyrethroid exposure for pest control workers in Japan 査読有り

WANG Dong, KAMIJIMA Michihiro, IMAI Ryota, SUZUKI Takayuki, KAMEDA Yohei, ASAI Kazumi, OKAMURA Ai, NAITO Hisao, UEYAMA Jun, SAITO Isao, NAKAJIMA Tamie, GOTO Masahiro, SHIBATA Eiji, KONDO Takaaki, TAKAGI Kenji, TAKAGI Kenzo, WAKUSAWA Shinya.

J Occup Health 49 巻 ( 6 ) 頁： 509-514 2007年11月

Lack of effect of aerobic physical exercise on endothelium-derived nitric oxide concentrations in healthy young subjects. 査読有り

YAMAMOTO Kanami, KONDO Takaaki, KIMATA Akiko, UEYAMA Jun, SHIROTORI Aya, OKADA Yoshiko, SAKUI Daisuke, NAKASHIMA Masahiro, YAMADA Sumio

Nagoya J Med Sci. 69 巻 ( 3-4 ) 頁： 167-172 2007年9月

Permethrin may disrupt testosterone biosynthesis via mitochondrial membrane damage of Leydig cells in adult male mouse 査読有り

ZHANG Shu-Yun, ITO Yuki, YAMANOSHITA Osamu, YANAGIBA Yukie, KOBAYASHI Miya, Taya Kazuyoshi, LI ChunMei, OKAMURA Ai, Miyata Maiko, UEYAMA Jun, LEE Chul-Ho, KAMIJIMA Michihiro, NAKAJIMA Tamie.

Endocrinology 148 巻 ( 8 ) 頁： 3941-3949 2007年8月

Association of a polymorphism in the ornithine decarboxylase gene with whole blood polyamine concentrations in a non-smoking healthy population 査読有り

KONDO Takaaki, HAMAJIMA Nobuyuki, NISHIO Kazuko, ISHIDA Yoshiko, IMAI Ryota, UEYAMA Jun, TORITA Shoko, KASAI Yurie, YAMAMOTO Ryoko, SUZUKI Koji, ITO Yoshinori.

J Health Sci 53 巻 ( 4 ) 頁： 406-412 2007年8月

Toxicity of diazinon and its metabolites increases in diabetic rats 査読有り

UEYAMA Jun, WANG Dong, KONDO Takaaki, SAITO Isao, TAKAGI Kenji, TAKAGI Kenzo, KAMIJIMA Michihiro, NAKAJIMA Tamie, MIYAMOTO K, WAKUSAWA Shinya, HASEGAWA Takaaki.

Toxicol Lett 170 巻 ( 3 ) 頁： 229-237 2007年4月

Lack of Effect of Aciclovir on Metabolism of Theophylline andExpression of Hepatic Cytochrome P450 1A2 in Rats 査読有り

NADAI Masayuki, KATO Miki, YASUI Kazumasa, KIMURA Masao, ZHAO Ying Lan, UEYAMA Jun, TSUNEKAWA Yoshimi, YOSHIZUMI Hideo, HASEGAWA Takaaki.

Biol Pharm Bull 30 巻 ( 3 ) 頁： 562-568 2007年3月

Serial Variations in Serum Hepatic Profiles among Occupational Pesticide Sprayers: Multilevel Analyses of 14-Year Health Check-up Data 査読有り

KONDO Takaaki, UEYAMA Jun, FUKAYA Yukio, GOTO Masahiro.

Bull Aichi Bunkyo Women's Coll 28 巻頁： 1-7 2007年3月

Involvement of nitric oxide (NO) in endotoxin-induced decrease in expression of hepatic cytochrome P450 査読有り

UEYAMA Jun, KONDO Takaaki, FUKAYA Yukio, HASEGAWA Takaaki.

Bull Aichi Bunkyo Women's Coll 28 巻頁： 9-16 2007年3月

8-Hydroxydeoxyguanosine levels in human leukocyte and urine according to exposure to organophosphorus pesticides and paraoxonase 1 genotype 査読有り

LEE Chul-Ho, KAMIJIMA Michihiro, KIM Heon, SHIBATA Eiji, UEYAMA Jun, SUZUKI Takayoshi, TAKAGI Kenji, SAITO Isao, GOTO Masahiro, HIBI Hattsuki, NAITO Hisao, NAKAJIMA Tamie.

Int Arch Occup Environ Health 80 巻 ( 3 ) 頁： 217-227 2007年1月

Association of abdominal circumference with serum nitric oxide concentration in healthy population 査読有り

KONDO Takaaki, UEYAMA Jun, IMAI Ryota, SUZUKI Koji, ITO Yoshinori

Environ Health Prev Med 11 巻 ( 6 ) 頁： 321-325 2006年12月

Protein kinase Cbeta isoform down-regulates the expression of MDR3 P-glycoprotein in human Chang liver cells 査読有り

SUZUKI Satoshi, HAYASHI Hisao, TAKAGI Kenji, KONDO Takaaki, TAKAGI Kenji, UEYAMA Jun, WAKUSAWA Shinya.

Biochim Biophys Acta 1760 巻 ( 10 ) 頁： 1552-1557 2006年10月

健常成人集団での加齢と経年的血圧変動との関連性　－一般線形混合モデルの適用－査読有り

近藤高明、渡邊ゆかり、上山　純、堀　容子、八谷　寛、玉腰浩司、豊嶋英明.

日循予防誌 41 巻 ( 2 ) 頁： 55-61 2006年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

職域での健常男性集団の4年間の健診データを用いて，肥満度と血圧との関連を明らかにするため多重レベル解析を実施した。BMIは収縮期血圧，拡張期血圧と有意な正の関連を示した。変量効果の推定値から，この直線関係での切片と傾きでは，個人間の変動が有意に大きいことも示した。

人工重力とエルゴメータ運動の併用により、無為臥床により惹起される心萎縮は防止可能である査読有り

岩瀬三紀, 武市康志, 石木良治, 稲垣春夫, 岩瀬敏, 井澤英夫, 永田浩三, 上山　純, 加藤洋介, 野田明子, 古池保雄, 横田充弘.

心臓 38 巻頁： 20-23 2006年4月

Simultaneous determination of urinary dialkyl phosphate metabolites of organophosphorus pesticides using gas chromatography-mass spectrometry 査読有り

UEYAMA Jun, SAITO Isao, KAMIJIMA Michihiro, NAKAJIMA Tamie, GOTOH Masahiro, SUZUKI Takayuki, SHIBATA Eiji, KONDO Takaaki, TAKAGI Kenji, MIYAMOTO Ken-ichi, TAKAMATSU Junki, HASEGAWA Takaaki, TAKAGI Kenzo

J Chromatogr B 832 巻頁： 58-66 2006年2月

A comprehensive evaluation of the testicular toxicity of dichlorvos in Wistar rats 査読有り

OKAMURA Ai, KAMIJIMA Michihiro, SHIBATA Eiji, OHTANI Katsumi, TAKAGI Kenji, UEYAMA Jun, WATANABE Yukari, OMURA Minoru, WANG Hailan, ICHIHARA Gaku, KONDO Takaaki, NAKAJIMA Tamie.

Toxicology 213 巻頁： 129-137 2005年9月

生活習慣病患者における血漿NOの検討査読有り

宮田聖子, 野田明子, 安藤晃禎, 吉村敦子, 上山　純, 北市清幸, 黒木祥子, 助川真代, 古池保雄, 横田充弘.

日本臨床生理学会雑誌 35 巻 ( 1 ) 頁： 39-43 2005年4月

Endotoxin from various gram-negative bacteria has differential effects on function of hepatic cytochrome P450 and drug transporters 査読有り

UEYAMA Jun, NADAI Masayuki, KANAZAWA Hiroaki, IWASE Mitsunori, NAKAYAMA Hironao, HASHIMOTO Katsunori, YOKOI T, BABA Kenji, TAKAGI Kenji, TAKAGI Kenzo, HASEGAWA Takaaki.

Eur J Pharmacol 510 巻頁： 127-134 2005年3月

Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin 査読有り

MIYOSHI Mika, NADAI Masayuki, NITTA Atsumi, UEYAMA Jun, SHIMIZU Akemi, TAKAGI Kenji, NABESHIMA Toshitaka, TAKAGI Kenji, SAITO Kuniaki, HASEGAWA Takaaki.

Eur J Pharmacol 507 巻頁： 229-237 2005年1月

Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats 査読有り

SHIMIZU Akemi, MIYOSHI Mika, SUGIE Masami, UEYAMA Jun, YAMAGUCHI Takuji, SASAKI Toshinobu, TAKAGI Kenji, JIN Mingji, MIYAMOTO Ken-ichi, TSUJI Akira, HASEGAWA Takaaki.

Eur J Pharmacol 501 巻頁： 151-159 2004年10月

Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity and expression of CYP3A2 and CYP2C11 査読有り

UEYAMA Jun, KITAICHI Kiyoyuki, NADAI Masayuki, IWASE Mitsunori, TOMYO Nao, KANAZAWA Hiroaki, SUZUKI Ryojiro, TAKAGI Kenji, TAKAGI Kenzo, HASEGAWA Takaaki.

Eur J Pharmacol 498 巻頁： 257-265 2004年9月

Down-regulation of cytochrome P450 proteins and its activities by Shiga-like toxin II from Escherichia coli O157:H7 査読有り

KITAICHI Kiyoyuki, NAKAYAMA Hironao, UEYAMA Jun, NADAI Masayuki, BABA Kenji, TAKAGI Kenji, TAKAGI Kenzo, OHTA Michio, HASEGAWA Takaaki

Biochem Pharmacol 67 巻頁： 1427-1435 2004年4月

Application of ultrafiltration method to measurement of catecholamines in plasma of human and rodents by high-performance liquid chromatography 査読有り

UEYAMA Jun, KITAICHI Kiyoyuki, IWASE Mitsunori, TAKAGI Kenji, TAKAGI Kenzo, HASEGAWA Takaaki

J Chromatogr B 798 巻頁： 35-41 2003年12月

Increased plasma concentration and brain penetration of methamphetamine in behaviorally sensitized rats 査読有り

KITAICHI Kiyoyukiiyoyuki, MORISHITA Yuki, DOI Yuko, UEYAMA Jun, MATSUSHIMA Miyoko, ZHAO Ying Lan, TAKAGI Kenji, HASEGAWA Takaaki

Eur J Pharmacol 464 巻頁： 39-48 2003年3月

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