研究者詳細 - 林　良敬

論文 - 林　良敬

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Glutaminostatin: Another facet of glucagon as a regulator of plasma amino acid concentrations 査読有り

Hayashi Yoshitaka

JOURNAL OF DIABETES INVESTIGATION 10 巻 ( 6 ) 頁： 1391 - 1393 2019年11月

Regulation of amino acid metabolism and α-cell proliferation by glucagon. 査読有り

Hayashi Y, Seino Y

Journal of diabetes investigation 9 巻 ( 3 ) 頁： 464 - 72 2018年1月

*Remodeling of Hepatic Metabolism and Hyperaminoacidemia in Mice Deficient in Proglucagon-derived Peptides. 査読有り

C. Watanabe, Y. Seino, H. Miyahira, M. Yamamoto, A. Fukami, N. Ozaki, Y. Takagishi, J. Sato, T. Fukuwatari, K. Shibata, Y. Oiso, Y. Murata, Y. Hayashi

Diabetes 61 巻 ( 1 ) 頁： 74-84 2012年1月

*Metabolic impact of glucagon deficiency. 招待有り査読有り

Yoshitaka Hayashi

Diabetes, Obesity and Metabolism. 13 巻 ( suppl 1 ) 頁： 151-157 2011年10月

*Mice Deficient for Glucagon Gene-Derived Peptides Display Normoglycemia, and Hyperplasia of Islet a-Cells but not of Intestinal L-cells. 査読有り

Y. Hayashi, M. Yamamoto, H. Mizoguchi, C. Watanabe, R. Ito, S. Yamamoto, X.Y. Sun, Y. Murata

Mol Endocrinol 23 巻 ( 12 ) 頁： 1990-1999 2009年12月

Advances in basic research on glucagon and alpha cells 査読有り

Hayashi, Y

DIABETOLOGY INTERNATIONAL 2024年2月

Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon-derived peptides 査読有り

Ueno, S; Seino, Y; Hidaka, S; Nakatani, M; Hitachi, K; Murao, N; Maeda, Y; Fujisawa, H; Shibata, M; Takayanagi, T; Iizuka, K; Yabe, D; Sugimura, Y; Tsuchida, K; Hayashi, Y; Suzuki, A

JOURNAL OF DIABETES INVESTIGATION 14 巻 ( 9 ) 頁： 1045 - 1055 2023年9月

A newly developed glucagon sandwich ELISA is useful for more accurate glucagon evaluation than the currently used sandwich ELISA in subjects with elevated plasma proglucagon-derived peptide levels 査読有り

Kobayashi, M; Maruyama, N; Yamamoto, Y; Togawa, T; Ida, T; Yoshida, M; Miyazato, M; Kitada, M; Hayashi, Y; Kashiwagi, A; Kitamura, T

JOURNAL OF DIABETES INVESTIGATION 14 巻 ( 5 ) 頁： 648 - 658 2023年5月

An analysis of intestinal morphology and incretin-producing cells using tissue optical clearing and 3-D imaging 査読有り

Hatoko, T; Harada, N; Tokumoto, S; Yamane, S; Ikeguchi-Ogura, E; Kato, T; Yasuda, T; Tatsuoka, H; Shimazu-Kuwahara, S; Yabe, D; Hayashi, Y; Inagaki, N

SCIENTIFIC REPORTS 12 巻 ( 1 ) 頁： 17530 2022年10月

High Protein Diet Feeding Aggravates Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides 査読有り

Ueno, S; Seino, Y; Hidaka, S; Maekawa, R; Takano, Y; Yamamoto, M; Hori, M; Yokota, K; Masuda, A; Himeno, T; Tsunekawa, S; Kamiya, H; Nakamura, J; Kuwata, H; Fujisawa, H; Shibata, M; Takayanagi, T; Sugimura, Y; Yabe, D; Hayashi, Y; Suzuki, A

NUTRIENTS 14 巻 ( 5 ) 2022年3月

Carbonic anhydrase 8 (CAR8) negatively regulates GLP-1 secretion from enteroendocrine cells in response to long-chain fatty acids 査読有り

Fujiwara Yuta, Yamane Shunsuke, Harada Norio, Ikeguchi-Ogura Eri, Usui Ryota, Nakamura Toshihiro, Iwasaki Kanako, Suzuki Kazuyo, Yabe Daisuke, Hayashi Yoshitaka, Inagaki Nobuya

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 320 巻 ( 4 ) 頁： G617 - G626 2021年4月

Short-Term High-Starch, Low-Protein Diet Induces Reversible Increase in -cell Mass Independent of Body Weight Gain in Mice 査読有り

Masuda, A; Seino, Y; Murase, M; Hidaka, S; Shibata, M; Takayanagi, T; Sugimura, Y; Hayashi, Y; Suzuki, A

NUTRIENTS 11 巻 ( 5 ) 2019年5月

Distribution and hormonal characterization of primary murine L cells throughout the gastrointestinal tract. 査読有り

Suzuki K, Iwasaki K, Murata Y, Harada N, Yamane S, Hamasaki A, Shibue K, Joo E, Sankoda A, Fujiwara Y, Hayashi Y, Inagaki N

Journal of diabetes investigation 9 巻 ( 1 ) 頁： 25 - 32 2018年1月

Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice 査読有り

Maekawa, R; Seino, Y; Ogata, H; Murase, M; Iida, A; Hosokawa, K; Joo, E; Harada, N; Tsunekawa, S; Hamada, Y; Oiso, Y; Inagaki, N; Hayashi, Y; Arima, H

JOURNAL OF NUTRITIONAL BIOCHEMISTRY 49 巻頁： 71 - 79 2017年11月

Acute Cholesterol-Lowering Effect of Exendin-4 in Ldlr(-/-) and C57BL/6J Mice. 査読有り

Hori M, Hasegawa Y, Hayashi Y, Nakagami T, Harada-Shiba M

Journal of atherosclerosis and thrombosis 2022年3月

Carbohydrate-induced weight gain models for diabetes research: Contribution of incretins and parasympathetic signal 査読有り

Seino Yusuke, Murase Masatoshi, Hayashi Yoshitaka, Suzuki Atsushi

JOURNAL OF DIABETES INVESTIGATION 12 巻 ( 1 ) 頁： 3 - 5 2021年1月

Glucagon regulates lipolysis and fatty acid oxidation through inositol triphosphate receptor 1 in the liver 査読有り

Hayashi Yoshitaka

JOURNAL OF DIABETES INVESTIGATION 12 巻 ( 1 ) 頁： 32 - 34 2021年1月

Deficiency of glucagon gene-derived peptides induces peripheral polyneuropathy in mice 査読有り

Motegi Mikio, Himeno Tatsuhito, Nakai-Shimoda Hiromi, Inoue Rieko, Ozeki Norio, Hayashi Yusuke, Sasajima Sachiko, Mohiuddin Mohammad Sarif, Asano-Hayami Emi, Kato Makoto, Asano Saeko, Miura-Yura Emiri, Morishita Yoshiaki, Kondo Masaki, Tsunekawa Shin, Kato Yoshiro, Kato Koichi, Naruse Keiko, Seino Yusuke, Hayashi Yoshitaka, Nakamura Jiro, Kamiya Hideki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 532 巻 ( 1 ) 頁： 47 - 53 2020年10月

Sphingosine kinase 1-interacting protein is a dual regulator of insulin and incretin secretion 査読有り

Liu Yanyan, Harashima Shin-ichi, Wang Yu, Suzuki Kazuyo, Tokumoto Shinsuke, Usui Ryota, Tatsuoka Hisato, Tanaka Daisuke, Yabe Daisuke, Harada Norio, Hayashi Yoshitaka, Inagaki Nobuya

FASEB JOURNAL 33 巻 ( 5 ) 頁： 6239 - 6253 2019年5月

Two Mutations in Thyroid Hormone Receptor Beta Gene (P453A and C36Y) in a Family with Resistance to Thyroid Hormone with Comorbid Myotonic Dystrophy 査読有り

Takeda Kyoko, Nemoto Ken-ichi, Hayashi Yoshitaka, Yamamoto Michiyo, Sakuta Ryoichi, Kimura Tetsuya, Noto Hiroshi

THYROID 29 巻 ( 4 ) 頁： 607 - 608 2019年4月

Functional adenosine triphosphate-sensitive potassium channel is required in high-carbohydrate diet-induced increase in β-cell mass. 査読有り

Murase M, Seino Y, Maekawa R, Iida A, Hosokawa K, Hayami T, Tsunekawa S, Hamada Y, Yokoi N, Seino S, Hayashi Y, Arima H

Journal of diabetes investigation 10 巻 ( 2 ) 頁： 238 - 250 2019年3月

Glucose-dependent insulinotropic polypeptide is required for moderate high-fat diet- but not high-carbohydrate diet-induced weight gain. 査読有り

Maekawa R, Ogata H, Murase M, Harada N, Suzuki K, Joo E, Sankoda A, Iida A, Izumoto T, Tsunekawa S, Hamada Y, Oiso Y, Inagaki N, Arima H, Hayashi Y, Seino Y

American journal of physiology. Endocrinology and metabolism 314 巻 ( 6 ) 頁： E572 - E583 2018年6月

The Mutant Thyroid Hormone Receptor Beta R320P Causes Syndrome of Resistance to Thyroid Hormone. 査読有り

Kimura T, Hayashi Y, Tsukamoto Y, Okamoto Y

Case reports in endocrinology 2018 巻頁： 4081769 2018年

Chronic high-sucrose diet increases fibroblast growth factor 21 production and energy expenditure in mice. 査読有り

Ryuya Maekawa, Yusuke Seino, Hidetada Ogata, Masatoshi Murase, Atsushi Iida, Kaori Hosokawa, Erina Joo, Norio Harada, Shin Tsunekawa, Yoji Hamada, Yutaka Oiso, Nobuya Inagaki, Yoshitaka Hayashi, Hiroshi Arima

J Nutr Biochem 49 巻頁： 71-79 2017年11月

Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. 査読有り

Atsushi Iida, Yusuke Seino, Ayako Fukami, Ryuya Maekawa, Daisuke Yabe, Shinobu Shimizu, Keita Kinoshita, Yusuke Takagi, Takako Izumoto, Hidetada Ogata, Kota Ishikawa, Nobuaki Ozaki, Shin Tsunekawa, Yoji Hamada, Yutaka Oiso, Hiroshi Arima, Yoshitaka Hayashi,

Diabetologia 59 巻 ( 7 ) 頁： 1533-1541 2016年4月

Mice Deficient in Proglucagon-Derived Peptides Exhibit Glucose Intolerance on a High-Fat Diet but Are Resistant to Obesity.

Takagi Y, Kinoshita K, Ozaki N, Seino Y, Murata Y, Oshida Y, Hayashi Y.

PLoS One. 10 巻 ( 9 ) 頁： e0138322 2015年9月

Chronic Hyponatremia Causes Neurologic and Psychologic Impairments.

Fujisawa H, Sugimura Y, Takagi H, Mizoguchi H, Takeuchi H, Izumida H, Nakashima K, Ochiai H, Takeuchi S, Kiyota A, Fukumoto K, Iwama S, Takagishi Y, Hayashi Y, Arima H, Komatsu Y, Murata Y, Oiso Y.

J Am Soc Nephrol. 頁： Epub ahead of print 2015年9月

*Pancreatic Neuroendocrine Tumors in Mice Deficient in Proglucagon-Derived Peptides.

Takano Y, Kasai K, Takagishi Y, Kikumori T, Imai T, Murata Y, Hayashi Y.

PLoS ONE 10 巻 ( 7 ) 頁： e0133812 2015年7月

グルカゴンの真の特異的作用は何か？グルカゴン作用欠損モデルの表現型. 招待有り

林　良敬

実験医学 33 巻 ( 6 ) 頁： 897-902 2015年4月

Low temperature-induced circulating triiodothyronine accelerates seasonal testicular regression.

K. Ikegami, Y. Atsumi, E. Yonenaga, H. Ono, I. Murayama, Y. Nakane, W. Ota, N. Arai, A. Tega, M. Iigo, V. M. Darras, K. Tsutsui, Y. Hayashi, S. Yoshida, Y. Yoshimura

Endocrinology 156 巻 ( 2 ) 頁： 647-659 2015年2月

Fatty acid-binding protein 5 regulates diet-induced obesity via GIP secretion from enteroendocrine K cells in response to fat ingestion.

Shibue K, Yamane S, Harada N, Hamasaki A, Suzuki K, Joo E, Iwasaki K, Nasteska D, Harada T, Hayashi Y, Adachi Y, Owada Y, Takayanagi R, Inagaki N.

Am J Physiol Endocrinol Metab. 308 巻 ( 7 ) 頁： E583-E591 2015年1月

Activation of the RhoB signaling pathway by thyroid hormone receptor ß in thyroid cancer cells.

Ichijo S, Furuya F, Shimura H, Hayashi Y, Takahashi K, Ohta K, Kobayashi T, Kitamura K.

PLoS One 9 巻 ( 12 ) 頁： e116252 2014年12月

Glucagon is essential for adaptive thermongenesis in brown adipose tissue 査読有り

K. Kinoshita, N. Ozaki, Y. Takagi, Y. Murata, Y. Oshida, Y. Hayashi

Endocrinology 155 巻 ( 9 ) 頁： 3484-3492 2014年6月

KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state. 査読有り

H. Ogata, Y. Seino, N. Harada, A. Iida, K. Suzuki, T. Izumoto, K. Ishikawa, E. Uenishi, N. Ozaki, Y. Hayashi, T. Miki, N. Inagaki, S. Tsunekawa, Y. Hamada, S. Seino, Y. Oiso

Journal of ENdocrinology 222 巻 ( 2 ) 頁： 191-200 2014年6月

Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice.

Okawa T, Kamiya H, Himeno T, Seino Y, Tsunekawa S, Hayashi Y, Harada N, Yamada Y, Inagaki N, Seino Y, Oiso Y, Nakamura J.

J Diabetes Investig 5 巻 ( 1 ) 頁： 31-37 2013年10月

Hyperthyroidism due to thyroid-stimulating hormone secretion after surgery for Cushing's syndrome: a novel cause of the syndrome of inappropriate secretion of thyroid-stimulating hormone. 査読有り

D. Tamada, T. Onodera, T. Kitamura, Y. Yamamoto, Y. Hayashi, Y. Murata, M. Otsuki, I. Shimomura

J Clin Endocrinol Metab 98 巻 ( 7 ) 頁： 2656-2662 2013年5月

S. Xu, Y. Hayashi, Y. Takagishi, M. Itoh, Y. Murata

PLoS One 8 巻 ( 5 ) 頁： e64415 2013年5月

Ectopic expression of GIP in pancreatic ß-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. 査読有り

A. Fukami, Y. Seino, N. Ozaki, M. Yamamoto, C. Sugiyama, E. Sakamoto-Miura, T. Himeno, Y. Takagishi, S. Tsunekawa, S. Ali, D. J. Drucker, Y. Murata, Y. Seino, Y. Oiso, Y. Hayashi

Diabetes 頁： doi: 10.2337/db12-0294 2012年10月

グルカゴンによる代謝制御招待有り

林　良敬

糖尿病と代謝 40 巻 ( 3 ) 頁： 1-8 2012年9月

Fertility and pregnancy-associated ß-cell proliferation in mice deficient in proglucagon-derived peptides. 査読有り

C. Sugiyama, M. Yamamoto, T. Kotani, F. Kikkawa, Y. Murata, Y. Hayashi

Plos One 2012年8月

Isolated growth hormone deficiency in two siblings because of paternal mosaicism for a mutation in the GH1 gene. 査読有り

M. Tsubahara, Y. Hayashi, S. Niijima, M. Yamamoto, T. Kamijo, Y. Murata, H. Haruna, A. Okumura, T. Shimizu

Clin Endocrinol (Oxf.) 76 巻 ( 3 ) 頁： 420-424 2012年3月

Aberrant promoter methylation in overexpression of CITED1 in papillary thyroid cancer. 査読有り

M. Sassa, Y. Hayashi, R. Watanabe, T. Kikumori, T. Imai, J. Kurebayashi, T. Kiuchi, Y. Murata

Thyroid 21 巻 ( 5 ) 頁： 511-517 2011年5月

A novel Caspr mutation causes the shambling mouse phenotype by disrupting axo-glial interactions of myelinated nerves. 査読有り

X.Y. Sun, Y. Takagishi, E. Okabe, Y. Chishima, Y. Kanou, S. Murase, K. Mizumura, M. Inaba, Y. Komatsu, Y. Hayashi, E. Peles, S. Oda, Y. Murata

J Neuropathol Exp Neurol 68 巻 ( 11 ) 頁： 1207-1218 2009年11月

Possible involvement of BRAFV600E in altered gene expression in papillary thyroid cancer. 招待有り査読有り

R. Watanabe, Y. Hayashi, M. Sassa, T. Kikumori, T. Imai, T. Kiuchih, Y. Murata

Endocr J 56 巻頁： 407-414 2009年6月

Prevention of neural tube defects by loss of function of inducible nitric oxide synthase in fetuses of a mouse model of streptozotocin-induced diabetes. 査読有り

Y. Sugimura, T. Murase, K. Oyama, A. Uchida, N. Sato, S. Hayasaka, Y. Kano, Y. Takagishi, Y. Hayashi, Y. Oiso, Y. Murata

Diabetologia 56 巻頁： 962-971 2009年5月

Oculocutaneous Albinism in Suncus murinus: Establishment of a Strain and Identification of its Responsible Gene. 査読有り

K. Tsuboi, Y. Hayashi, T. Jogahara, G. Ogura, Y. Murata,S. Oda

Exp Anim 58 巻 ( 1 ) 頁： 31-40 2009年1月

Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains. 査読有り

Ido H, Ito S, Taniguchi Y, Hayashi M, Sato-Nishiuchi R, Sanzen N, Hayashi Y, Futaki S, Sekiguchi K

J Biol Chem 283 巻 ( 42 ) 頁： 28149-28157 2008年10月

Identification of genes differentially expressed in mouse fetuses from streptozotocin-induced diabetic pregnancy by cDNA subtraction. 査読有り

Sato N, Sugimura Y, Hayashi Y, Murase T, Kanou Y, Kikkawa F, Murata Y

Endocr J 55 巻 ( 2 ) 頁： 317-323 2008年5月

Insertion of an intracisternal A particle retrotransposon element in plasma membrane calcium ATPase 2 gene attenuates its expression and produces an ataxic phenotype in joggle mutant mice. 査読有り

Sun XY, Chen ZY, Hayashi Y, Kanou Y, Takagishi Y, Oda S, Murata Y

Gene 411 巻 ( 1-2 ) 頁： 94-102 2008年3月

Long-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile. 査読有り

R.Q. Shi, J. K. Lee, Y. Hayashi, Y. Takeuchi, F. Kambe, S. Futaki, H. Seo, Y. Murata, I. Kodama

Eur J Parmacol 578 巻頁： 270-278 2008年

Mapping of jog locus to the region between D6Mit104 and D6Mit336 on mouse chromosome 6. 査読有り

Sun XY, Chen ZY, Kanou Y, Hayashi Y, Ohno T, Murata Y, Oda S

56 巻 ( 5 ) 頁： 389-392 2007年10月

A case with isolated growth hormone deficiency caused by compound heterozygous mutations in GH-1: a novel missense mutation in the initiation codon and a 7.6kb deletion 査読有り

Hayashi Y, Kamijo T, Yamamoto M, Murata Y, Phillips JA 3rd, Ogawa M, Seo H.

Growth Horm IGF Res 17 巻 ( 36 ) 頁： 249-253 2007年6月

Molecular cloning of prostaglandin EP3 receptors from canine sensory ganglia and their facilitatory action on bradykinin-induced mobilization of intracellular calcium 査読有り

Kozaki Y, Kambe F, Hayashi Y, Ohmori S, Seo H, Kumazawa T, Mizumura K

J Neurochem 100 巻 ( 6 ) 頁： 1636-1647 2007年3月

Regulation of mesodermal differentiation of mouse embryonic stem cells by basement membranes. 査読有り

Fujiwara H, Hayashi Y, Sanzen N, Kobayashi R, Weber CN, Emoto T, Futaki S, Niwa H, Murray P, Edgar D, Sekiguchi K.

J Biol Chem 282 巻頁： 29701-29711 2007年

The Sp family of transcription factors regulates the human laminin alpha1 gene in JAR choriocarcinoma cells. 査読有り

Niimi T, Hayashi Y, Sekiguchi K, Kitagawa Y.

Biochim Biophys Acta 2006 巻 ( 11-12 ) 頁： 573-579 2006年11月

A novel large-scale production system for modified basement membrane matrices using gene-swapped parietal endoderm cells. 査読有り

Hayashi Y, Weber CN, Emoto T, Fujiwara H, Sanzen N, Futaki S, Sekiguchi K.

Matrix Biol 25 巻 ( 2 ) 頁： 85-88 2006年3月

Activation of the RhoB signaling pathway by thyroid hormone receptor ß in thyroid cancer cells. 査読有り

S. Ichijo, F. Furuya, H. Shimura, Y. Hayashi, K. Takahashi, K. Ohta, T. Kobayashi, K. Kitamura.

PLoS ONE 9 巻 ( 12 ) 頁： e116252 2005年12月

Growth hormone releasing hormone receptor (GHRH-r) gene mutation in Indian children with familial isolated growth hormone deficiency: a study from western India 査読有り

Desai MP, Upadhye PS, Kamijo T, Yamamoto M, Ogawa M, Hayashi Y, Seo H, Nair SR.

J Pediatr Endocrinol Metab 18 巻 ( 10 ) 頁： 1955-973 2005年10月

The transcriptional landscape of the mammalian genome. 査読有り

Carninci P et al FANTOM Consortium; RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group).

Science 309 巻頁： 1559-1563 2005年9月

Sox7 Plays Crucial Roles in Parietal Endoderm Differentiation in F9 Embryonal Carcinoma Cells through Regulating Gata-4 and Gata-6 Expression. 査読有り

S. Futaki, Y. Hayashi, T. Emoto, C.N. Weber, K. SekiguchiS. Futaki, Y. Hayashi, T. Emoto, C.N. Weber, K. Sekiguchi

Mol Cell Biol 24 巻 ( 12 ) 頁： 10495-10503 2004年12月

A nonsense mutation (E72X) in growth hormone releasing hormone receptor (GHRHR) gene is the major cause of familial isolated growth hormone deficiency in Western region of India: founder effect suggested by analysis of dinucleotide repeat polymorphism close to GHRHR gene 査読有り

Kamijo, T. Hayashi, Y. Seo, H. Yamamoto, M. Ogawa, M. Choski, C. S. Sawant, N. J. Colaco, M. P. Desai, M. P.

Growth Horm IGF Res 14 巻 ( 5 ) 頁： 394-401 2004年10月

SOX7 and SOX17 Regulate the Parietal Endoderm-specific Enhancer Activity of Mouse Laminin {alpha}1 Gene 査読有り

Niimi, T. Hayashi, Y. Futaki, S. Sekiguchi, K.

J Biol Chem 279 巻 ( 36 ) 頁： 38055-38061 2004年9月

Establishment and characterization of a parietal endoderm-like cell line derived from Engelbreth-Holm-Swarm tumor (EHSPEL), a possible resource for an engineered basement membrane matrix 査読有り

Hayashi, Y. Emoto, T. Futaki, S. Sekiguchi, K.

Matrix Biol 23 巻 ( 1 ) 頁： 47-62 2004年4月

Molecular dissection of the alpha -dystroglycan- and integrin-binding sites within the globular domain of human laminin-10 査読有り

Ido, H. Harada, K. Futaki, S. Hayashi, Y. Nishiuchi, R. Natsuka, Y. Li, S. Wada, Y. Combs, A. C. Ervasti, J. M. Sekiguchi, K.

J Biol Chem 279 巻 ( 12 ) 頁： 10946-10954 2004年3月

Molecular basis of constitutive production of basement membrane components: Gene expression profiles of engelbreth-holm-swarm tumor and F9 embryonal carcinoma cells 査読有り

Futaki, S. Hayashi, Y. Yamashita, M. Yagi, K. Bono, H. Hayashizaki, Y. Okazaki, Y. Sekiguchi, K.

J Biol Chem 278 巻 ( 50 ) 頁： 50691-50701 2003年

A role for thyroid hormone transporters in transcriptional regulation by thyroid hormone receptors 査読有り

Ritchie, J. W. Shi, Y. B. Hayashi, Y. Baird, F. E. Muchekehu, R. W. Christie, G. R. Taylor, P. M.

Mol Endocrinol 17 巻 ( 4 ) 頁： 653-661 2003年

Identification of an upstream enhancer in the mouse laminin alpha 1 gene defining its high level of expression in parietal endoderm cells 査読有り

Niimi, T. Hayashi, Y. Sekiguchi, K.

J Biol Chem 278 巻 ( 11 ) 頁： 9332-9338 2003年

Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo 査読有り

Takeuchi, Y. Murata, Y. Sadow, P. Hayashi, Y. Seo, H. Xu, J. O'Malley, B. W. Weiss, R. E. Refetoff, S.

Endocrinology 143 巻 ( 4 ) 頁： 1346-1352 2002年

Type 1 iodothyronine deiodinase in the house musk shrew (Suncus murinus, Insectivora: Soricidae): cloning and characterization of complementary DNA, unique tissue distribution and regulation by T(3) 査読有り

Rogatcheva, M. Hayashi, Y. Oda, S. Seo, H. Cua, K. Refetoff, S. Murakami, M. Mori, M. Murata, Y.

Gen Comp Endocrinol 127 巻 ( 1 ) 頁： 48-58 2002年

Identification and recombinant production of human laminin alpha4 subunit splice variants 査読有り

Hayashi, Y. Kim, K. H. Fujiwara, H. Shimono, C. Yamashita, M. Sanzen, N. Futaki, S. Sekiguchi, K.

Biochem Biophys Res Commun 299 巻 ( 3 ) 頁： 498-504 2002年

Familial isolated growth hormone deficiency: genetics and pathophysiology 招待有り査読有り

Hayashi, Y. Kamijo, T. Ogawa, M. Seo, H.

Endocr J 49 巻 ( 3 ) 頁： 265-272 2002年

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha 査読有り

Macchia, P. E. Takeuchi, Y. Kawai, T. Cua, K. Gauthier, K. Chassande, O. Seo, H. Hayashi, Y. Samarut, J. Murata, Y. Weiss, R. E. Refetoff, S.

Proc Natl Acad Sci U S A 98 巻 ( 1 ) 頁： 349-354 2001年

Somatic gene alteration of AIB1 gene in patients with breast cancer 査読有り

Shibata, A. Hayashi, Y. Imai, T. Funahashi, H. Nakao, A. Seo, H.

Endocr J 48 巻 ( 2 ) 頁： 199-204 2001年

Involvement of AP-1 and steroidogenic factor (SF)-1 in the cAMP-dependent induction of human adrenocorticotropic hormone receptor (ACTHR) promoter 査読有り

Sarkar, D. Kambe, F. Hayashi, Y. Ohmori, S. Funahashi, H. Seo, H.

Endocr J 47 巻 ( 1 ) 頁： 63-75 2000年

Identification of a novel myosin-Va mutation in an ataxic mutant rat, dilute-opisthotonus 査読有り

Futaki, S. Takagishi, Y. Hayashi, Y. Ohmori, S. Kanou, Y. Inouye, M. Oda, S. Seo, H. Iwaikawa, Y. Murata, Y.

Mamm Genome 11 巻 ( 8 ) 頁： 649-655 2000年

A novel mutation at the donor splice site of intron 3 of the GH-I gene in a patient with isolated growth hormone deficiency 査読有り

Hayashi, Y. Kamijo, T. Yamamoto, M. Ohmori, S. Phillips, J. A., 3rd Ogawa, M. Igarashi, Y. Seo, H.

Growth Horm IGF Res 9 巻 ( 6 ) 頁： 434-437 1999年

Glucocorticoids increase retinoid-X receptor alpha (RXRalpha) expression and enhance thyroid hormone action in primary cultured rat hepatocytes 査読有り

Yamaguchi, S. Murata, Y. Nagaya, T. Hayashi, Y. Ohmori, S. Nimura, Y. Seo, H.

J Mol Endocrinol 22 巻 ( 1 ) 頁： 81-90 1999年

A Japanese family with autosomal dominant growth hormone deficiency 査読有り

Saitoh, H. Fukushima, T. Kamoda, T. Tanae, A. Kamijo, T. Yamamoto, M. Ogawa, M. Hayashi, Y. Ohmori, S. Seo, H.

Eur J Pediatr 158 巻 ( 8 ) 頁： 624-627 1999年

9-cis-retinoic acid decreases the level of its cognate receptor, retinoid X receptor, through acceleration of the turnover 査読有り

Nomura, Y. Nagaya, T. Hayashi, Y. Kambe, F. Seo, H.

Biochem Biophys Res Commun 260 巻 ( 3 ) 頁： 729-733 1999年

Responsiveness to thyroid hormone is enhanced in rat hepatocytes cultured as spheroids compared with that in monolayers: altered responsiveness to thyroid hormone possibly involves complex formed on thyroid hormone response elements 査読有り

Menjo, M. Yamaguchi, S. Murata, Y. Hayashi, Y. Nagaya, T. Ohmori, S. Refetoff, S. Seo, H.

Thyroid 9 巻 ( 9 ) 頁： 959-967 1999年

Polymorphism of homopolymeric glutamines in coactivators for nuclear hormone receptors 査読有り

Hayashi, Y. Yamamoto, M. Ohmori, S. Kikumori, T. Imai, T. Funahashi, H. Seo, H.

Endocr J 46 巻 ( 2 ) 頁： 279-284 1999年

Mutations in intron 3 of GH-1 gene associated with isolated GH deficiency type II in three Japanese families 査読有り

Kamijo, T. Hayashi, Y. Shimatsu, A. Kinoshita, E. Yoshimoto, M. Ogawa, M. Seo, H.

Clin Endocrinol (Oxf) 51 巻 ( 3 ) 頁： 355-360 1999年

Hereditary isolated growth hormone deficiency caused by GH1 gene mutations in Japanese patients

Kamijo, T. Hayashi, Y. Seo, H. Ogawa, M.

Growth Horm IGF Res 9 巻 ( suppl B ) 頁： 31-34 1999年

Inhibition of growth hormone (GH) secretion by a mutant GH-I gene product in neuroendocrine cells containing secretory granules: an implication for isolated GH deficiency inherited in an autosomal dominant manner 査読有り

Hayashi, Y. Yamamoto, M. Ohmori, S. Kamijo, T. Ogawa, M. Seo, H.

J Clin Endocrinol Metab 84 巻 ( 6 ) 頁： 2134-2139 1999年

Selective pituitary resistance to thyroid hormone produced by expression of a mutant thyroid hormone receptor beta gene in the pituitary gland of transgenic mice 査読有り

Hayashi, Y. Xie, J. Weiss, R. E. Pohlenz, J. Refetoff, S.

Biochem Biophys Res Commun 245 巻 ( 1 ) 頁： 204-10 1998年

Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor beta-deficient mice 査読有り

Weiss, R. E. Murata, Y. Cua, K. Hayashi, Y. Seo, H. Refetoff, S.

Endocrinology 139 巻 ( 12 ) 頁： 4945-4952 1998年

Molecular cloning of sucrase-isomaltase cDNA in the house musk shrew Suncus murinus and identification of a mutation responsible for isolated sucrase deficiency 査読有り

Ito, T. Hayashi, Y. Ohmori, S. Oda, S. Seo, H.

J Biol Chem 273 巻 ( 26 ) 頁： 16464-16469 1998年

Tumor suppressor p53 is a negative regulator in thyroid hormone receptor signaling pathways 査読有り

Bhat, M. K. Yu, C. Yap, N. Zhan, Q. Hayashi, Y. Seth, P. Cheng, S.

J Biol Chem 272 巻 ( 46 ) 頁： 28989-28983 1997年

Resistance to thyroid hormone caused by two mutant thyroid hormone receptors beta, R243Q and R243W, with marked impairment of function that cannot be explained by altered in vitro 3,5,3'-triiodothyroinine binding affinity 査読有り

Yagi, H. Pohlenz, J. Hayashi, Y. Sakurai, A. Refetoff, S.

J Clin Endocrinol Metab 82 巻 ( 5 ) 頁： 1608-1614 1997年

A splicing variant of Steroid Receptor Coactivator-1 (SRC-1E): the major isoform of SRC-1 to mediate thyroid hormone action 査読有り

Hayashi, Y. Ohmori, S. Ito, T. Seo, H.

Biochem Biophys Res Commun 236 巻 ( 1 ) 頁： 83-87 1997年

Modification of thyroid hormone and 9-cis retinoic acid signaling by overexpression of their cognate receptors using adenoviral vector 査読有り

Hayashi, Y. Yamaguchi, S. Pohlenz, J. Murata, Y. Refetoff, S. Seo, H.

Mol Cell Endocrinol 131 巻 ( 1 ) 頁： 59-66 1997年

A mouse model of resistance to thyroid hormone produced by somatic gene transfer of a mutant thyroid hormone receptor 査読有り

Hayashi, Y. Mangoura, D. Refetoff, S.

Mol Endocrinol 10 巻 ( 1 ) 頁： 100-106 1996年

Dominant inheritance of resistance to thyroid hormone not linked to defects in the thyroid hormone receptor alpha or beta genes may be due to a defective cofactor 査読有り

Weiss, R. E. Hayashi, Y. Nagaya, T. Petty, K. J. Murata, Y. Tunca, H. Seo, H. Refetoff, S.

J Clin Endocrinol Metab 81 巻 ( 12 ) 頁： 4196-4203 1996年

Resistance to thyrotropin and other abnormalities of the thyrotropin receptor

Refetoff, S. Sunthornthepvarakul, T. Gottschalk, M. E. Hayashi, Y.

Recent Prog Horm Res 51 巻頁： 97-120 1996年

Thyroxine-binding globulin: organization of the gene and variants 査読有り

Refetoff, S. Murata, Y. Mori, Y. Janssen, O. E. Takeda, K. Hayashi, Y.

Horm Res 45 巻 ( 3-5 ) 頁： 128-138 1996年

Expression of thyroid peroxidase in EBV-transformed B cell lines using adenovirus 査読有り

Hidaka, Y. Hayashi, Y. Fisfalen, M. E. Suzuki, S. Takeda, T. Refetoff, S. DeGroot, L. J.

Thyroid 6 巻 ( 1 ) 頁： 23-28 1996年

Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase 査読有り

Eggerickx, D. Denef, J. F. Labbe, O. Hayashi, Y. Refetoff, S. Vassart, G. Parmentier, M. Libert, F.

Biochem J 309 巻 ( 3 ) 頁： 837-843 1995年

Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants 査読有り

Yen, P. M. Wilcox, E. C. Hayashi, Y. Refetoff, S. Chin, W. W.

Endocrinology 136 巻 ( 7 ) 頁： 2845-2851 1995年

Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene 査読有り

Sunthornthepvarakul, T. Gottschalk, M. E. Hayashi, Y. Refetoff, S.

N Engl J Med 332 巻 ( 3 ) 頁： 155-160 1995年

Expression of human thyrotropin receptor by recombinant adenovirus 査読有り

Okamoto, Y. Hayashi, Y. DeGroot, L. J.

Thyroid 5 巻 ( 1 ) 頁： 51-53 1995年

Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-beta receptors? 査読有り

Hayashi, Y. Weiss, R. E. Sarne, D. H. Yen, P. M. Sunthornthepvarakul, T. Marcocci, C. Chin, W. W. Refetoff, S.

J Clin Endocrinol Metab 80 巻 ( 11 ) 頁： 3246-3256 1995年

Expression of a thyroid hormone-responsive recombinant gene introduced into adult mice livers by replication-defective adenovirus can be regulated by endogenous thyroid hormone receptor 査読有り

Hayashi, Y. DePaoli, A. M. Burant, C. F. Refetoff, S.

J Biol Chem 269 巻 ( 39 ) 頁： 23872-23875 1994年

A new point mutation (C446R) in the thyroid hormone receptor-beta gene of a family with resistance to thyroid hormone 査読有り

Weiss, R. E. Chyna, B. Duell, P. B. Hayashi, Y. Sunthornthepvarakul, T. Refetoff, S.

J Clin Endocrinol Metab 78 巻 ( 5 ) 頁： 1253-1256 1994年

Polymorphism of a variant human thyrotropin receptor (hTSHR) gene 査読有り

Sunthornthepvarakul, T. Hayashi, Y. Refetoff, S.

Thyroid 4 巻 ( 2 ) 頁： 147-149 1994年

An identical missense mutation in the albumin gene results in familial dysalbuminemic hyperthyroxinemia in 8 unrelated families 査読有り

Sunthornthepvarakul, T. Angkeow, P. Weiss, R. E. Hayashi, Y. Refetoff, S.

Biochem Biophys Res Commun 202 巻 ( 2 ) 頁： 781-787 1994年

Resistance to thyroid hormone in subjects from two unrelated families is associated with a point mutation in the thyroid hormone receptor beta gene resulting in the replacement of the normal proline 453 with serine 査読有り

Refetoff, S. Weiss, R. E. Wing, J. R. Sarne, D. Chyna, B. Hayashi, Y.

Thyroid 4 巻 ( 3 ) 頁： 249-254 1994年

Mutations of CpG dinucleotides located in the triiodothyronine (T3)-binding domain of the thyroid hormone receptor (TR) beta gene that appears to be devoid of natural mutations may not be detected because they are unlikely to produce the clinical phenotype of resistance to thyroid hormone 査読有り

Hayashi, Y. Sunthornthepvarakul, T. Refetoff, S.

J Clin Invest 94 巻 ( 2 ) 頁： 607-615 1994年

The relative expression of mutant and normal thyroid hormone receptor genes in patients with generalized resistance to thyroid hormone determined by estimation of their specific messenger ribonucleic acid products 査読有り

Hayashi, Y. Janssen, O. E. Weiss, R. E. Murata, Y. Seo, H. Refetoff, S.

J Clin Endocrinol Metab 76 巻 ( 1 ) 頁： 64-69 1993年

Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation 査読有り

Hayashi, Y. Mori, Y. Janssen, O. E. Sunthornthepvarakul, T. Weiss, R. E. Takeda, K. Weinberg, M. Seo, H. Bell, G. I. Refetoff, S.

Mol Endocrinol 7 巻 ( 8 ) 頁： 1049-1060 1993年

Modification of water and electrolyte metabolism during head-down tilting by hypoglycemia in men 査読有り

Hayashi, Y. Murata, Y. Seo, H. Miyamoto, N. Kambe, F. Ohmori, S. Yamamoto, C. Hayamizu, S. Tamura, Y. Matsui, N.

J Appl Physiol 73 巻 ( 5 ) 頁： 1785-1790 1992年

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