Organization
Graduate School of Medicine Center for Neurological Diseases and Cance Assistant Professor
Graduate School
Graduate School of Medicine
Undergraduate School
School of Medicine
Title
Assistant Professor
AKASHI, Tomohiro
Degree 1
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理学博士 （ 1990.3 大阪大学 ）
Research Interests 1
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microtubule, tubulin, cell division, cell polarity, mitotic inhibitors, secondary metabolism
Research Areas 2
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Life Science / Cell biology / Cell Biology
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Nanotechnology/Materials / Chemistry and chemical methodology of biomolecules / Living Organism Molecular Science
Current Research Project and SDGs 3
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multi-omics analysis of fungal secondary metabolites
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Molecular Biology of γ-tubulins in non-animal cells
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The role of secretion and cytoskeleton in apical growth of fungi
Research History 1
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Nagoya University
2008.4
Education 1
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Osaka University Graduate School, Division of Natural Science
- 1990.3
Country： Japan
Professional Memberships 3
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Americal Society of Cell Biology
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植物形態学会
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植物学会
Awards 2
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日本植物形態学会平瀬賞
2004.9 日本植物形態学会
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日本植物形態学会奨励賞
2002.9 日本植物形態学会
Papers 32
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Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice.
Komine O, Ohnuma S, Hinohara K, Hara Y, Shimada M, Akashi T, Watanabe S, Sobue A, Kawade N, Ogi T, Yamanaka K
iScience Vol. 27 ( 2 ) page： 108872 2024.2
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BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state
Xiao, MR; Kondo, S; Nomura, M; Kato, S; Nishimura, K; Zang, WJ; Zhang, YF; Akashi, T; Viny, A; Shigehiro, T; Ikawa, T; Yamazaki, H; Fukumoto, M; Tanaka, A; Hayashi, Y; Koike, Y; Aoyama, Y; Ito, H; Nishikawa, H; Kitamura, T; Kanai, A; Yokoyama, A; Fujiwara, T; Goyama, S; Noguchi, H; Lee, SC; Toyoda, A; Hinohara, K; Abdel-Wahab, O; Inoue, D
NATURE COMMUNICATIONS Vol. 14 ( 1 ) page： 8372 2023.12
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Suzuki, K; Tange, M; Yamagishi, R; Hanada, H; Mukai, S; Sato, T; Tanaka, T; Akashi, T; Kadomatsu, K; Maeda, T; Miida, T; Takeuchi, I; Murakami, H; Sekido, Y; Murakami-Tonami, Y
CELL DEATH DISCOVERY Vol. 8 ( 1 ) page： 446 2022.11
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Near Infrared Photo-Antimicrobial Targeting Therapy for <i>Candida albicans</i>
Yasui, H; Takahashi, K; Taki, S; Shimizu, M; Koike, C; Umeda, K; Rahman, S; Akashi, T; Nguyen, V; Nakagawa, Y; Sato, K
ADVANCED THERAPEUTICS Vol. 4 ( 2 ) 2021.2
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Quantitative Assessment of T Cell Clonotypes in Human Acute Graft-versus-Host Disease Tissues.
Koyama D, Murata M, Hanajiri R, Akashi T, Okuno S, Kamoshita S, Julamanee J, Takagi E, Miyao K, Sakemura R, Goto T, Terakura S, Nishida T, Kiyoi H
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation Vol. 25 ( 3 ) page： 417 - 423 2019.3
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Grau Michelle F., Entwistle Ruth, Chiang Yi-Ming, Ahuja Manmeet, Oakley C. Elizabeth, Akashi Tomohiro, Wang Clay C. C., Todd Richard B., Oaldey Berl R.
ACS CHEMICAL BIOLOGY Vol. 13 ( 11 ) page： 3193 - 3205 2018.11
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Mu P, Akashi T, Lu F, Kishida S, Kadomatsu K.
Oncogene Vol. 36 ( 41 ) page： 5745 - 5756 2017.10
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A Child with Epidermolytic Ichthyosis from a Parent with Epidermolytic Nevus: Risk Evaluation of Transmission from Mosaic to Germline. Reviewed
Kono M, Suga Y, Akashi T, Ito Y, Takeichi T, Muro Y, Akiyama M.
J Invest Dermatol Vol. 137 ( 9 ) page： 2024-2026 2017.9
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Kono Michihiro, Suga Yasushi, Akashi Tomohiro, Ito Yasutomo, Takeichi Takuya, Muro Yoshinao, Akiyama Masashi
JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 137 ( 9 ) page： 2024 - 2026 2017.9
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Discovery of McrA, a master regulator of Aspergillus secondary metabolism Reviewed
C. E. Oakley, M. Ahuja, W.-W. Sun, R. Entwistle, T. Akashi, J. Yaegashi, C.-J. Guo, G. C. Cerqueira, J. R. Wortman, C. C. C. Wang, Y.-M. Chiang, B. R. Oakley
Mol Microbial Vol. 103 ( 2 ) page： 347 - 365 2017.1
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*Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases Reviewed
Ban R, Matsuzaki H, Akashi T, Sakashita G, Taniguchi H, Park SY, Tanaka H, Furukawa K, Urano T.
J Biol. Chem. Vol. 284 page： 28367-28381 2009.10
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PCNA mono-ubiquitination and activation of translesion DNA polymerases by DNA polymerase {alpha} Reviewed
Suzuki M, Niimi A, Limsirichaikul S, Tomida S, Miao Huang Q, Izuta S, Usukura J, Itoh Y, Hishida T, Akashi T, Nakagawa Y, Kikuchi A, Pavlov Y, Murate T, Takahashi T.
J. Biochem. Vol. 146 ( 1 ) page： 13-21 2009.7
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*Dynamic association of topoisomerase II to the mitotic chromosomes in live cells of Aspergillus nidulans. Reviewed
Kawagishi M, Akashi T, Kikuchi A
Biochemical Biophysical Research Communications Vol. 334 page： 324-332 2005
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Centrosome as an organizing center of intracellular information: insights viewed from the spindle pole of budding yeast Invited
Tomohiro Akashi
Seikagaku Vol. 77 page： 261-268 2005
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*Gamma-tubulin in basal land plants: characterization, localization, and implication in the evolution of acentriolar microtubule organizing centers Reviewed
Shimamura, M., Brown, R.C., Lemmon, B.E., Akashi, T., Mizuno, K., Nishihara, N., Tomizawa, K., Yoshimoto, K., Deguchi, H., Hosoya, H., Horio, T., and Mineyuki, Y.
Plant Cell Vol. 16 page： 45-59 2004
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*Involvement of nucleocytoplasmic shuttling of yeast Nap1 in mitotic progression. Reviewed
Miyaji-Yamaguchi M, Kato K, Nakano R, Akashi T, Kikuchi A, Nagata K.
Molecular Cellular Biology Vol. 23 page： 6672-6684 2003
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Molecular and structural characterization of the spindle pole bodies in the fission yeast Schizosaccharomyces japonicus var. japonicus Reviewed
Horio, T., Kimura, N., Basaki, A., Tanaka, Y., Noguchi, T., Akashi, T. and Tanaka, K.
Yeast Vol. 19 page： 1335-1350 2002
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Divergencies of gamma-tubulin and gamma-tubulin-related proteins Invited Reviewed
Tomohiro Akashi
Plant Morphology Vol. 13 page： 21-30 2001
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NBP1 (Nap1 binding protein 1), an essential gene for G2/M transition of Saccharomyces cerevisiae, encodes a protein of distinct sub-nuclear localization. Reviewed
Shimizu Y, Akashi T, Okuda A, Kikuchi A, Fukui K.
Gene Vol. 246 page： 395-404 2000
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Involvement of the cytoskeleton in the intracellular distribution of mannoproteins in hyphal cells of Candida albicans
Journal of Plant Research Vol. 111 page： 531-540 1998
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Characterization of γ-tubulin complexes in Aspergillus nidulans and detection of putative γ-tubulin interacting proteins Reviewed
Cell Motility and the Cytoskeleton Vol. 37 page： 149-158 1997
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Localized accumulation of cell wall mannoproteins and endomembranes induced by brefeldin A in hyphal cells of the dimorphic yeast Candida albicans Reviewed
Protoplasma Vol. 197 page： 45-56 1997
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The role of cytoskeleton for induction and ongoing for germ tube growth of candida albicans
Microbiology Vol. 140 page： 271-280 1994
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Cytoskeleton in yeasts : dynamic behaviors in the cell cycle
Protein, Nucleic acid and Enzyme Vol. 39 ( 4 ) page： 373-382 1994
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Changes in the distribution of F-actin in the fission yeast Schizosaccharomyces pombe by arresting growth in distilled water : correlative studies with fluorescence and electron microscopy
Journal of Electron Microscopy Vol. 43 page： 20-24 1994
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Ultrastructure of proteinase secreting cells of candida albicans, studied by alkaline bismuth staining and immuno cytochemistry
Journal of General Microbiology Vol. 139 page： 2185-2195 1993
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Enhancement of extracapsular polysaccharide synthesis in Klebsiella pneumoniae by RmpA2, which shows homology to NtrC and FixJ
Infection and Immunity Vol. 61 page： 3164-3174 1993
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Effect of cytochalasin A on actin distribution in the fission yeast schizosaccharomyces pombe by fluorescent and electron microscopy
Protoplasma Vol. 176 page： 24-32 1993
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Involvement of transmembrane proteins in the association of cortical microtubules with the plasma membrane in tobacco BY-2 cells.
Journal of Cell Science Vol. 98 page： 169-174 1991
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Stabilization of cortical microtubules by the cell wall in cultured tobacco cells.
Planta Vol. 182 page： 363-369 1990
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Effects of propyzamide on tobacco cell microtubules in vivo and in vitro.
Plant and Cell Physiology Vol. 29 page： 1053-1062 1988
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Effects of gibberellin on the arrangement and the cold stability of cortical microtubules in epidermal cells of pea internodes.
Plant and Cell Physiology Vol. 28 page： 339-348 1987
Research Project for Joint Research, Competitive Funding, etc. 1
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ＩＭＳによる土壌由来カビ検出データベースの構築
2009.10 - 2012.3
科学技術振興機構先端計測分析技術・機器開発事業
Grant type：Competitive
KAKENHI (Grants-in-Aid for Scientific Research) 2
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カビ代謝ペプチドの解析のためのフラグメンテーション理論の新展開
2012.4 - 2015.3
科学研究費補助金 基盤研究(C)
Authorship：Coinvestigator(s)
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細胞の極性成長を支える多分子間相互作用ネットワークの解析
2007
科学研究費補助金 基盤研究(C)，課題番号：19570181
紅 朋浩
Authorship：Principal investigator
Teaching Experience (On-campus) 24
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生物学基礎I
2021
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真菌学実習
2021
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生体と微生物
2021
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CIBoG Gene and genome analysis: Basics of NGS analysis
2021
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病理病態学
2021
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病理病態学
2020
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生物学基礎I
2020
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CIBoG Gene and genome analysis: Basics of NGS analysis
2020
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生体と微生物
2020
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真菌学実習
2020
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Gene and genome analysis: yeast two hybrid system and NGS analysis
2019
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病理病態学
2019
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生物学基礎I
2019
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真菌学実習
2019
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生体と微生物
2019
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Gene and genome analysis: yeast two hybrid system and NGS analysis
2019
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Gene and genome analysis: yeast two hybrid system and NGS analysis
2018
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Gene and genome analysis: yeast two hybrid system and NGS analysis
2017
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Gene and genome analysis: yeast two hybrid system and NGS analysis
2016
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Gene and genome analysis: yeast two hybrid system and NGS analysis
2015
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Gene and genome analysis: yeast two hybrid system and NGS analysis
2014
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Gene analyses with yeast
2013
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酵母two hybrid system
2012
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酵母two hybrid system
2010
Social Contribution 1
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スーパーサイエンスハイスクール
2011.7